Nephrology, Dialysis, Transplantation

Alexandru Burlacu, Adrian Iftene, Eugen Busoiu, Dragos Cogean, Adrian Covic
No abstract text is available yet for this article.
November 7, 2019: Nephrology, Dialysis, Transplantation
Minjung Kang, Yong Chul Kim, Hajeong Lee, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Ho Jun Chin, Seung Seok Han
BACKGROUND: Horseshoe kidney (HSK) is a congenital disorder that is usually asymptomatic, but that increases the risks of kidney stones and infectious disease. However, renal outcomes such as end-stage renal disease (ESRD) in patients with HSK remain unclear. METHODS: In total, 146 patients with HSK (age of ≥20 years) from two tertiary hospitals were included in this study. Control individuals who underwent medical check-ups were selected by matching for age, sex, serum creatinine level, hypertension and diabetes...
November 7, 2019: Nephrology, Dialysis, Transplantation
Per-Ola Sundin, Ruzan Udumyan, Katja Fall, Scott Montgomery
No abstract text is available yet for this article.
November 7, 2019: Nephrology, Dialysis, Transplantation
Jasna Aleksova, Frances Milat, Mark A Kotowicz, Julie A Pasco, Chris Schultz, Phillip Wong, Peter R Ebeling, Grahame J Elder
BACKGROUND: Patients with end-stage kidney disease (ESKD) have higher fracture rates and post-fracture mortality than the general population, but bone mineral density by dual-energy X-ray absorptiometry (DXA) is less predictive of fracture in this patient group. Bone biopsy and high-resolution imaging indicate that cortical thickness (CT) is reduced and cortical porosity is increased in ESKD. The aim of this study was to assess cortical parameters using DXA in patients with ESKD. It was hypothesized that these parameters would show deterioration and be associated with fracture...
November 7, 2019: Nephrology, Dialysis, Transplantation
Kamyar Kalantar-Zadeh, Holly M Kramer, Denis Fouque
No abstract text is available yet for this article.
November 7, 2019: Nephrology, Dialysis, Transplantation
Ulrika Hahn Lundström, Ulf Hedin, Alessandro Gasparini, Fergus J Caskey, Juan-Jesus Carrero, Marie Evans
BACKGROUND: There is controversial evidence on whether arteriovenous access (AVA) placement may protect renal function and hence should be considered in the timing of access placement. This study aimed to investigate the association between AVA placement and estimated glomerular filtration rate (eGFR) decline as compared with the placement of a peritoneal dialysis catheter (PDC) at a similar time point. METHODS: We studied a cohort of 744 pre-dialysis patients in Stockholm, Sweden, who underwent surgery for AVA or PDC between 2006 and 2012...
October 30, 2019: Nephrology, Dialysis, Transplantation
Pascale Khairallah, Thomas L Nickolas, Maria Fusaro
No abstract text is available yet for this article.
October 29, 2019: Nephrology, Dialysis, Transplantation
Justine Bacchetta, Claus Peter Schmitt, Gema Ariceta, Sevcan A Bakkaloglu, Jaap Groothoff, Mandy Wan, Marc Vervloet, Rukshana Shroff, Dieter Haffner
Secondary hyperparathyroidism (SHPT) is an important complication of advanced chronic kidney disease (CKD) in children, which is often difficult to treat with conventional therapy. The calcimimetic cinacalcet is an allosteric modulator of the calcium-sensing receptor. It has proven to be effective and safe in adults to suppress parathyroid hormone (PTH), but data on its use in children are limited. To date, studies in children only consist of two randomized controlled trials, nine uncontrolled interventional or observational studies, and case reports that report the efficacy of cinacalcet as a PTH-lowering compound...
October 22, 2019: Nephrology, Dialysis, Transplantation
Ahmed A Awan, Carl P Walther, Peter A Richardson, Maulin Shah, Wolfgang C Winkelmayer, Sankar D Navaneethan
BACKGROUND: Anemia is associated with adverse outcomes in those with chronic kidney disease (CKD). We examined the association of absolute and functional iron deficiency anemia (IDA) with adverse outcomes (cardiovascular hospitalization, dialysis and mortality) in those with nondialysis-dependent CKD. METHODS: Nondialysis-dependent CKD patients followed in the US Veterans Administration with hemoglobin level measured within 90 days of the date of the second estimated glomerular filtration rate <60 mL/min/1...
October 22, 2019: Nephrology, Dialysis, Transplantation
Christian Combe, Claire Rigothier, Philippe Chauveau
No abstract text is available yet for this article.
October 21, 2019: Nephrology, Dialysis, Transplantation
Jacob J E Koopman, Aiko P J de Vries, Ingeborg M Bajema
No abstract text is available yet for this article.
October 17, 2019: Nephrology, Dialysis, Transplantation
Maria Fusaro, Rachel Holden, Charmaine Lok, Giorgio Iervasi, Mario Plebani, Andrea Aghi, Maurizio Gallieni, Mario Cozzolino
In chronic kidney disease (CKD), phosphate homoeostasis plays a central role in the development of mineral and bone disorder (MBD) together with decreased serum calcium and elevated serum parathyroid hormone, fibroblast growth factor 23 and sclerostin levels. Today there are only a few data exploring the direct role of abnormal phosphate homoeostasis and hyperphosphataemia in the development of CKD-MBD. On the other hand, several studies have looked at the link between hyperphosphataemia and cardiovascular morbidity and mortality in CKD, but there is a lack of evidence to indicate that lowering phosphate levels improves cardiovascular outcomes in this population...
October 17, 2019: Nephrology, Dialysis, Transplantation
Anique D Ter Braake, Coby Eelderink, Lara W Zeper, Andreas Pasch, Stephan J L Bakker, Martin H de Borst, Joost G J Hoenderop, Jeroen H F de Baaij
BACKGROUND: Phosphate (Pi) toxicity is a strong determinant of vascular calcification development in chronic kidney disease (CKD). Magnesium (Mg2+) may improve cardiovascular risk via vascular calcification. The mechanism by which Mg2+ counteracts vascular calcification remains incompletely described. Here we investigated the effects of Mg2+ on Pi and secondary crystalline calciprotein particles (CPP2)-induced calcification and crystal maturation. METHODS: Vascular smooth muscle cells (VSMCs) were treated with high Pi or CPP2 and supplemented with Mg2+ to study cellular calcification...
October 12, 2019: Nephrology, Dialysis, Transplantation
Manliu Wang, Jicheng Lv, Pei Chen, Guizhen Yu, Sufang Shi, Lijun Liu, Xujie Zhou, Damin Xu, Minghui Zhao, Hong Zhang
BACKGROUND: Both ABO blood group antigens and pathogenic immunoglobulin A1 (IgA1) in patients with IgA nephropathy (IgAN) are influenced by modifications of N-acetylgalactosamine and galactose. The purpose of this study was to assess whether ABO blood type is associated with galactose-deficient IgA1 (Gd-IgA1) in the progression of kidney disease in patients with IgAN. METHODS: We enrolled 1313 IgAN patients with a median of 44 months follow-up and measured the plasma Gd-IgA1 levels...
October 11, 2019: Nephrology, Dialysis, Transplantation
Kate A Robinson, Luke A Baker, Matthew P M Graham-Brown, Emma L Watson
Skeletal muscle wasting is a common complication of chronic kidney disease (CKD), characterized by the loss of muscle mass, strength and function, which significantly increases the risk of morbidity and mortality in this population. Numerous complications associated with declining renal function and lifestyle activate catabolic pathways and impair muscle regeneration, resulting in substantial protein wasting. Evidence suggests that increasing skeletal muscle mass improves outcomes in CKD, making this a clinically important research focus...
October 11, 2019: Nephrology, Dialysis, Transplantation
Takamasa Iwakura, Julian A Marschner, Zhi Bo Zhao, Monika Katarzyna Świderska, Hans-Joachim Anders
Electric cell-substrate impedance sensing (ECIS) is a quantitative, label-free, non-invasive analytical method allowing continuous monitoring of the behaviour of adherent cells by online recording of transcellular impedance. ECIS offers a wide range of practical applications to study cell proliferation, migration, differentiation, toxicity and monolayer barrier integrity. All of these applications are relevant for basic kidney research, e.g. on endothelial cells, tubular and glomerular epithelial cells. This review gives an overview on the fundamental principles of the ECIS technology...
October 10, 2019: Nephrology, Dialysis, Transplantation
Yu Ho Lee, Ki Pyo Kim, Sun-Hwa Park, Dong-Jin Kim, Yang-Gyun Kim, Ju-Young Moon, Su-Woong Jung, Jin Sug Kim, Kyung-Hwan Jeong, So-Young Lee, Dong-Ho Yang, Sung-Jig Lim, Jeong-Taek Woo, Sang Youl Rhee, Suk Chon, Hoon-Young Choi, Hyeong-Cheon Park, Young-Il Jo, Joo-Hark Yi, Sang-Woong Han, Sang-Ho Lee
BACKGROUND: Interstitial fibrosis and tubular atrophy (IFTA) is a well-recognized risk factor for poor renal outcome in patients with diabetic kidney disease (DKD). However, a noninvasive biomarker for IFTA is currently lacking. The purpose of this study was to identify urinary markers of IFTA and to determine their clinical relevance as predictors of renal prognosis. METHODS: Seventy patients with biopsy-proven isolated DKD were enrolled in this study. We measured multiple urinary inflammatory cytokines and chemokines by multiplex enzyme-linked immunosorbent assay in these patients and evaluated their association with various pathologic features and renal outcomes...
October 10, 2019: Nephrology, Dialysis, Transplantation
Manon J M van Oosten, Susan J J Logtenberg, Martijn J H Leegte, Henk J G Bilo, Sigrid M Mohnen, Leona Hakkaart-van Roijen, Marc H Hemmelder, G Ardine de Wit, Kitty J Jager, Vianda S Stel
BACKGROUND: The financial burden of chronic kidney disease (CKD) is increasing due to the ageing population and increased prevalence of comorbid diseases. Our aim was to evaluate age-related differences in health care use and costs in Stage G4/G5 CKD without renal replacement therapy (RRT), dialysis and kidney transplant patients and compare them to the general population. METHODS: Using Dutch health care claims, we identified CKD patients and divided them into three groups: CKD Stage G4/G5 without RRT, dialysis and kidney transplantation...
October 9, 2019: Nephrology, Dialysis, Transplantation
Jolanta Malyszko
No abstract text is available yet for this article.
October 9, 2019: Nephrology, Dialysis, Transplantation
Carmine Zoccali, Peter J Blankestijn, Annette Bruchfeld, Giovambattista Capasso, Danilo Fliser, Denis Fouque, Dimitrios Goumenos, Ziad Massy, Ivan Rychlık, Maria J Soler, Kate Stevens, Goce Spasovski, Christoph Wanner
In January 2019, the ERA-EDTA surveyed nephrologists with questions on kidney care and kidney research designed to explore comprehension of the impact of alterations to organization of renal care and of advancements in technology and knowledge of kidney disease. Eight hundred and twenty-five ERA-EDTA members, ∼13% of the whole ERA-EDTA membership, replied to an ad hoc questionnaire. More than half of the respondents argued that kidney centres will be increasingly owned by large dialysis providers, nearly a quarter of respondents felt that many medical aspects of dialysis will be increasingly overseen by non-nephrologists and a quarter (24%) also believed that the care and long-term follow-up of kidney transplant patients will be increasingly under the responsibility of transplant physicians caring for patients with any organ transplant...
October 9, 2019: Nephrology, Dialysis, Transplantation
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