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Journals Nephrology, Dialysis, Transpla...

Nephrology, Dialysis, Transplantation

https://read.qxmd.com/read/38486367/clinical-impact-of-the-kidney-failure-risk-equation-for-vascular-access-planning
#1
JOURNAL ARTICLE
Ulrika Hahn Lundström, Chava L Ramspek, Friedo W Dekker, Merel van Diepen, Juan Jesus Carrero, Ulf Hedin, Marie Evans
BACKGROUND: Risk-based thresholds for arteriovenous (AV) access creation has been proposed to aid vascular access planning. We aimed to assess the clinical impact of implementing the kidney failure risk equation (KFRE) for vascular access referral. METHODS: 16,102 nephrology-referred chronic kidney disease (CKD) patients from the Swedish Renal Registry 2008-2018 were included. The KFRE was calculated repeatedly, and the timing was identified for when the KFRE risk exceeded several pre-defined thresholds and/or the estimated glomerular filtration rate <15 ml/min/1...
March 14, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38486353/ethical-challenges-of-clinical-innovations-and-medical-progress
#2
JOURNAL ARTICLE
Valerie A Luyckx
No abstract text is available yet for this article.
March 14, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38486352/klotho-in-pregnancy-and-intrauterine-development-potential-clinical-implications-a-review-from-the-european-renal-association-ckd-mbd-working-group
#3
JOURNAL ARTICLE
Mehmet Kanbay, Ali Mutlu, Cicek N Bakir, Ibrahim B Peltek, Ata A Canbaz, Juan Miguel Díaz Tocados, Mathias Haarhaus
Intrauterine development is crucial for life-long health; therefore, elucidation of its key regulators is of interest for their potential prognostic and therapeutic implications. Originally described as a membrane-bound anti-aging protein, Klotho has evolved as a regulator of numerous functions in different organ systems. Circulating Klotho is generated by alternative splicing or active shedding from cell membranes. Recently, Klotho was identified as a regulator of placental function, and while Klotho does not cross the placental barrier, increased levels of circulating α-Klotho have been identified in umbilical cord blood compared to maternal blood, indicating that Klotho may also play a role in intrauterine development...
March 14, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38479785/pre-donation-assessment-of-cystatin-c-to-improve-prediction-of-pre-and-post-donation-gfr-in-potential-living-kidney-donors
#4
JOURNAL ARTICLE
Jessica van der Weijden, Daan Kremer, Lisa B Westenberg, Jan-Stephan F Sanders, Robert A Pol, Ilja M Nolte, Martin H De Borst, Stefan P Berger, Stephan J L Bakker, Marco van Londen
BACKGROUND AND HYPOTHESIS: Accurate estimation of glomerular filtration rate (GFR) is crucial in living kidney donation. While most eGFR equations are based on plasma creatinine, its levels are strongly influenced by muscle mass. Application of cystatin C (CysC)-based estimates before donation may improve both estimation of current GFR and prediction of post-donation GFR. METHODS: We assessed the performance of CKD-EPI equations based on creatinine (eGFRcreat-2009, eGFRcreat-2021), cystatin C (eGFRCysC-2012), or both (eGFRcombined-2012, eGFRcombined-2021) for estimating pre- and post-donation measured GFR in 486 living kidney donors...
March 13, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38460949/sex-differences-in-cancer-outcomes-across-the-range-of-egfr
#5
JOURNAL ARTICLE
Richard Shemilt, Michael K Sullivan, Peter Hanlon, Bhautesh Jani, Nicole De La Mata, Brenda Rosales, Benjamin M P Elyan, James A Hedley, Rachel B Cutting, Melanie Wyld, David A McAllister, Angela C Webster, Patrick B Mark, Jennifer S Lees
BACKGROUND AND HYPOTHESIS: People with chronic kidney disease (CKD) have increased incidence and mortality from most cancer types. We hypothesised that odds of presenting with advanced cancer may vary according to differences in eGFR, that this could contribute to increased all-cause mortality and that sex differences may exist. METHODS: Data were from Secure Anonymised Information Linkage Databank, including people with de-novo cancer diagnosis (2011-2017) and two kidney function tests within two years prior to diagnosis to determine baseline eGFR (mL/min/1...
March 9, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38460948/physical-exercise-a-polypill-against-chronic-kidney-disease
#6
JOURNAL ARTICLE
Pedro L Valenzuela, Adrián Castillo-García, Gonzalo Saco-Ledo, Alejandro Santos-Lozano, Alejandro Lucia
We are currently facing a pandemic of physical inactivity that might contribute to the growing prevalence of chronic kidney disease (CKD). Here, we summarize currently available evidence on the association between physical activity and CKD, and also review the effects of exercise intervention in affected patients. Physical activity/exercise might act as a polypill against CKD, preventing its development or even exerting beneficial effects once it is established (i.e. improvements in patients' physical fitness and cardiovascular risk, as well as in kidney function)...
March 9, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38453435/efficacy-tolerability-and-safety-of-the-oral-phosphate-binder-vs-505-ap301
#7
JOURNAL ARTICLE
Bing Zhuang, Liangying Gan, Bin Liu, Weijie Yuan, Ming Shi, Ai Peng, Lihua Wang, Xiaolan Chen, Tongqiang Liu, Shiying Zhang, Song Wang, Qing Gao, Baoxing Wang, Huixiao Zheng, Changhua Liu, Yuan Luo, Hong Ye, Hongli Lin, Yiwen Li, Qiang He, Feng Zheng, Ping Luo, Gang Long, Wei Lu, Kanghui Li, Junwei Yang, Yingxue Cathy Liu, Zhizheng Zhang, Xiaolin Li, Weifeng Zhang, Li Zuo
BACKGROUND: VS-505 (AP301), an acacia and ferric oxyhydroxide polymer, is a novel fiber-iron-based phosphate binder. This two-part phase 2 study evaluated the tolerability, safety, and efficacy of oral VS-505 administered three times daily with meals in treating hyperphosphatemia in chronic kidney disease (CKD) patients receiving maintenance hemodialysis (MHD). METHODS: In Part 1, patients received dose-escalated treatment with VS-505 2.25, 4.50, and 9.00 g/day for 2 weeks each, guided by serum phosphorus levels...
March 7, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38444170/obinutuzumab-is-effective-for-the-treatment-of-frequently-relapsing-steroid-dependent-minimal-change-disease-in-adults
#8
JOURNAL ARTICLE
Li Jin, Xueying Liu, Huixian Li, Xiangyun Dang, Zhigang Wang, Dan Niu, Xiaotian Zhang, Jiping Sun, Dapeng Hao, Wanhong Lu
No abstract text is available yet for this article.
March 5, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38439701/a-comparison-of-the-epidemiology-of-kidney-replacement-therapy-between-europe-and-the-united-states-2021-data-of-the-era-registry-and-the-usrds
#9
JOURNAL ARTICLE
Vianda S Stel, Rianne Boenink, Megan E Astley, Brittany A Boerstra, Danilo Radunovic, Rannveig Skrunes, Juan C Ruiz San Millán, Maria F Slon Roblero, Samira Bell, Pablo Ucio Mingo, Marc A G J Ten Dam, Patrice M Ambühl, Halima Resic, Olga Lucia Rodríguez Arévalo, Nuria Aresté-Fosalba, Jaume Tort I Bardolet, Mathilde Lassalle, Sara Trujillo-Alemán, Olafur S Indridason, Marta Artamendi, Patrik Finne, Marta Rodríguez Camblor, Dorothea Nitsch, Kristine Hommel, George Moustakas, Julia Kerschbaum, Mirjana Lausevic, Kitty J Jager, Alberto Ortiz, Anneke Kramer
BACKGROUND AND HYPOTHESIS: This paper compares the most recent data on the incidence and prevalence of kidney replacement therapy (KRT), kidney transplantation rates, and mortality on KRT from Europe to those from the United States (US), including comparisons of treatment modalities (haemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KTx)). METHODS: Data were derived from the annual reports of the European Renal Association (ERA) Registry and the United States Renal Data System (USRDS)...
March 4, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38439675/how-can-inhibition-of-glucose-and-sodium-transport-in-the-early-proximal-tubule-protect-the-cardiorenal-system
#10
JOURNAL ARTICLE
Volker Vallon
What mechanisms can link the inhibition of SGLT2-mediated Na+-coupled glucose reabsorption in early proximal tubules to kidney and heart protection in patients with and without type 2 diabetes? Due to physical and functional coupling of SGLT2 to other sodium and metabolite transporters in the early proximal tubule (including NHE3, URAT1), inhibitors of SGLT2 (SGLT2i) reduce reabsorption not only of glucose, inducing osmotic diuresis, but of other metabolites plus of a larger amount of sodium than expected based on SGLT2 inhibition alone, thereby reducing volume retention, hypertension, and hyperuricemia...
March 4, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38429978/cold-atmospheric-plasma-for-chronic-kidney-disease-related-skin-disorders
#11
JOURNAL ARTICLE
Siyue Zhai, Dingxin Liu, Hua Liu, Wanchun Li, Zifeng Wang, Meng Wang, Lei Chen, Hongli Jiang
BACKGROUND AND HYPOTHESIS: An estimated 80% of individuals with chronic kidney disease (CKD) experience concomitant skin disorders, yet experimental research that elucidates the pathological changes in CKD-affected skin is limited. Cold atmospheric plasma (CAP) has shown promise in regulating keratinocyte proliferation, skin barrier function, and anti-inflammatory activity. We hypothesize that CAP emerges as a promising therapeutic avenue for CKD-related skin diseases. METHODS: Male and female C57/BL6 mice were administered a 0...
March 1, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38429977/intradialytic-cycling-and-cognitive-training-to-mitigate-decreased-functional-and-physiological-status-in-haemodialysis-patients
#12
JOURNAL ARTICLE
Špela Bogataj, Bart Roelands, Maja Pajek, Jernej Pajek
No abstract text is available yet for this article.
March 1, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38425090/proximal-versus-distal-diuretics-in-congestive-heart-failure
#13
JOURNAL ARTICLE
Massimo Nardone, Vikas S Sridhar, Kevin Yau, Ayodele Odutayo, David Z I Cherney
Volume overload represents a hallmark clinical feature linked to the development and progression of heart failure (HF). Alleviating signs and symptoms of volume overload represents a foundational HF treatment target that is achieved using loop diuretics in the acute and chronic setting. Recent work has provided evidence to support guideline-directed medical therapies, such as sodium glucose cotransporter 2 (SGLT2) inhibitors and mineralocorticoid receptor (MR) antagonists, as important adjunct diuretics that may act synergistically when used with background loop diuretics in people with chronic HF...
February 29, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38425037/hyperkalemia-treatment-standard
#14
JOURNAL ARTICLE
Biff F Palmer, Deborah J Clegg
Hyperkalemia is a common electrolyte disturbance in both inpatient and outpatient clinical practice. The severity and associated risk depends on the underlying cause and rate of K+ increase. Acute hyperkalemia requires immediate attention due to potentially life-threatening manifestations resulting from the rapid rise in plasma K+ concentration. Treatment is initially focused on stabilizing the cardiac membrane, followed by maneuvers to shift K+ into the cell, and ultimately initiating strategies to decrease total body K+ content...
February 29, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38425029/ckd-screening-for-better-kidney-health-why-who-how-when
#15
JOURNAL ARTICLE
Katherine R Tuttle
No abstract text is available yet for this article.
February 29, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38409858/a-tool-to-predict-the-risk-of-lower-extremity-amputation-in-patients-starting-dialysis
#16
JOURNAL ARTICLE
Bram Akerboom, Roemer J Janse, Aurora Caldinelli, Bengt Lindholm, Joris I Rotmans, Marie Evans, Merel van Diepen
BACKGROUND AND HYPOTHESIS: Non-traumatic lower extremity amputation (LEA) is a severe complication during dialysis. To inform decision-making for physicians, we developed a multivariable prediction model for LEA after starting dialysis. METHODS: Data from the Swedish Renal Registry (SNR) between 2010 and 2020 were geographically split into a development and validation cohort. Data from NECOSAD between 1997 and 2009 were used for validation targeted at Dutch patients...
February 26, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38402463/urine-cotinine-versus-self-reported-smoking-and-the-risk-of-chronic-kidney-disease
#17
JOURNAL ARTICLE
Setor K Kunutsor, Richard S Dey, Daan J Touw, Stephan J L Bakker, Robin P F Dullaart
BACKGROUND AND HYPOTHESIS: Evidence on the role of smoking in the development of chronic kidney disease (CKD) has mostly relied on self-reported smoking status. We aimed to compare the associations of smoking status as assessed by self-reports and urine cotinine with CKD risk. METHODS: Using the PREVEND prospective study, smoking status was assessed at baseline using self-reports and urine cotinine in 4333 participants (mean age, 52 years) without a history of CKD at baseline...
February 24, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38402460/iga-nephropathy-gut-microbiome-regulates-the-production-of-hypoglycosilated-iga1via-the-tlr4-signaling-pathway
#18
JOURNAL ARTICLE
Yifan Zhu, Haidong He, Weiqian Sun, Jiajun Wu, Yong Xiao, Yinshun Peng, Ping Hu, Meiping Jin, Ping Liu, DongLiang Zhang, Jiajun Wu, Ting Xie, Lusheng Huang, Weiming He, Minggang Wei, Lishun Wang, Xudong Xu, Yuyan Tang
BACKGROUND: IgA nephropathy (IgAN) is a major cause of primary glomerulonephritis characterized by mesangial deposits of galactose-deficient IgA1 (Gd-IgA1). Toll-like receptors (TLRs), particularly TLR4 are involved in the pathogenesis of IgAN. The role of gut microbiota on IgAN patients was recently investigated. However, whether gut microbial modifications of Gd-IgA1 through TLR4 play a role in IgAN remains unclear. METHODS: We recruited subjects into four groups, including 48 patients with untreated IgAN, 22 treated IgAN patients (IgANIT), 22 primary membranous nephropathy (MN), and 31 healthy controls (HCs)...
February 24, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38400561/alkaline-phosphatase-treatment-of-acute-kidney-injury-an-update
#19
JOURNAL ARTICLE
Thei S Steenvoorden, Janneke A J Rood, Frederike J Bemelman, Roberto Armstrong-Jr, Henri G D Leuvenink, Joost W van der Heijden, Liffert Vogt
Through improved insight in the increasing incidence and detrimental effects of acute kidney injury (AKI), its clinical relevance has become more and more apparent. Although treatment strategies for AKI have also somewhat improved, an adequate remedy still does not exist. Finding one is complicated by a multifactorial pathophysiology and by heterogeneity in the patient population. Alkaline phosphatase (AP) has been suggested as a therapy for sepsis-associated AKI because of its protective effects against lipopolysaccharide (LPS) induced inflammation and kidney injury in animals...
February 23, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38400552/altered-adiponectin-regulation-in-skeletal-muscle-of-patients-with-chronic-kidney-disease
#20
JOURNAL ARTICLE
Daniela Verzola, Michela Saio, Samantha Milanesi, Daniela Picciotto, Marco Frascio, Giuliano Brunori, Alessandro Laudon, Edoardo La Porta, Noemi Rumeo, Valentina Zanetti, Elisa Russo, Giacomo Garibotto, Francesca Viazzi, Pasquale Esposito
No abstract text is available yet for this article.
February 23, 2024: Nephrology, Dialysis, Transplantation
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