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Youbao Li, Dan Li, Yun Song, Lan Gao, Fangfang Fan, Binyan Wang, Min Liang, Guobao Wang, Jianping Li, Yan Zhang, Xin Xu, Fan Fan Hou, Xiaoshu Cheng, Ningling Sun, Yingxian Sun, Lianyou Zhao, Qijun Wan, Xiaoming Li, Junnong Li, Qinghua Han, Xiping Xu, Yong Huo, Xianhui Qin
BACKGROUND: Data on the association between visit-to-visit variability (VVV) in blood pressure (BP) and the risk of chronic kidney disease (CKD) in general treated hypertensive patients were limited. We aimed to evaluate the relation of VVV in BP with the development of CKD, and examine any possible effect modifiers in hypertensive patients without prior cardiovascular diseases (CVDs) or CKD. METHODS: This is a post hoc analysis of the Renal Sub-study of the China Stroke Primary Prevention Trial (CSPPT)...
May 18, 2019: Nephrology, Dialysis, Transplantation
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Talia Gutman, Allison Tong, Martin Howell, Kathryn Dansie, Carmel M Hawley, Jonathan C Craig, Shilpanjali Jesudason, Jeremy R Chapman, David W Johnson, Lisa Murphy, Donna Reidlinger, Sally Crowe, Emily Duncanson, Shyamsundar Muthuramalingam, Nicole Scholes-Robertson, Amber Williamson, Stephen McDonald
BACKGROUND: There is widespread recognition that research will be more impactful if it arises from partnerships between patients and researchers, but evidence on best practice for achieving this remains limited. METHODS: We convened workshops in three Australian cities involving 105 patients/caregivers and 43 clinicians/researchers. In facilitated breakout groups, participants discussed principles and strategies for effective patient involvement in chronic kidney disease research...
May 15, 2019: Nephrology, Dialysis, Transplantation
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Frederick W K Tam, Albert C M Ong
No abstract text is available yet for this article.
May 14, 2019: Nephrology, Dialysis, Transplantation
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Lukas Konrad, Kirstin Andersen, Marie Sophie Kesper, Santhosh V Kumar, Shrikant R Mulay, Hans-Joachim Anders
BACKGROUND: Dysbiosis, bacterial translocation and systemic inflammation have been found to be associated with human and experimental forms of chronic kidney disease (CKD), but the functional contribution of the intestinal microbiota to CKD-related intestinal barrier dysfunction and CKD progression is unknown, especially in CKD secondary to hyperoxaluria and nephrocalcinosis. METHODS: C57BL/6N mice fed an oxalate-rich diet for either 10 or 20 days developed reversible or progressive kidney disease, respectively...
May 12, 2019: Nephrology, Dialysis, Transplantation
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Nattachai Srisawat, Win Kulvichit, Noppathorn Mahamitra, Cameron Hurst, Kearkiat Praditpornsilpa, Nuttha Lumlertgul, Anan Chuasuwan, Konlawij Trongtrakul, Adis Tasnarong, Ratapum Champunot, Rangsun Bhurayanontachai, Manasnun Kongwibulwut, Pornlert Chatkaew, Petchdee Oranrigsupak, Theerapon Sukmark, Thanachai Panaput, Natthapon Laohacharoenyot, Karjbundid Surasit, Thathsalang Keobounma, Kamol Khositrangsikun, Ummarit Suwattanasilpa, Pattharawin Pattharanitima, Poramin Santithisadeekorn, Anocha Wanitchanont, Sadudee Peerapornrattana, Passisd Loaveeravat, Asada Leelahavanichkul, Khajohn Tiranathanagul, Stephen J Kerr, Kriang Tungsanga, Somchai Eiam-Ong, Visith Sitprija, John A Kellum
BACKGROUND: Etiologies for acute kidney injury (AKI) vary by geographic region and socioeconomic status. While considerable information is now available on AKI in the Americas, Europe and China, large comprehensive epidemiologic studies of AKI from Southeast Asia (SEA) are still lacking. The aim of this study was to investigate the rates and characteristics of AKI among intensive care unit (ICU) patients in Thailand. METHODS: We conducted the largest prospective observational study of AKI in SEA...
May 10, 2019: Nephrology, Dialysis, Transplantation
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Yuanyuan Shi, Yumei Zhang, Huajun Tian, Yifeng Wang, Yue Shen, Qiuyu Zhu, Feng Ding
BACKGROUND: Protein-bound uremic toxins (PBUTs) have received extensive attention, as their accumulation leads to pleiotropic toxic biological effects, while the removal of these solutes by conventional dialysis therapies is severely hampered. This study aimed to examine whether increased removal of PBUTs could be achieved with intravenous lipid emulsion (ILE). METHODS: PBUTs such as 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF), p-cresyl sulfate (PCS) and indoxyl sulfate (IS) were spiked with human serum albumin (HSA) solution and the inhibitory effects of free fatty acid (FFA) on the binding of CMPF, PCS and IS to HSA were examined separately in vitro by ultrafiltration...
May 9, 2019: Nephrology, Dialysis, Transplantation
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François-Xavier Lescure, Soraya Fellahi, Gilles Pialoux, Jean-Philippe Bastard, Anne-Line Eme, Emmanuel Esteve, Marie-Gisèle Lebrette, Jean-Baptiste Guiard-Schmid, Jacqueline Capeau, Pierre Ronco, Dominique Costagliola, Emmanuelle Plaisier
BACKGROUND: The incidence of chronic kidney disease (CKD) is 10 times higher in human immunodeficiency virus (HIV)-infected patients than in the general population. We explored the prevalence and determinants of proximal tubular dysfunction (PTD) in HIV-infected individuals, and assessed the impact of the tubulopathy on the estimated glomerular filtration rate (eGFR) outcome. METHODS: A cohort study was performed on 694 outpatients followed in a French centre to analyse the prevalence of PTD, the diagnosis performance of screening tools and the associated factors...
May 9, 2019: Nephrology, Dialysis, Transplantation
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Wan-Han Hsu, Kuo-Feng Hua, Li-Heng Tuan, Yu-Ling Tsai, Lichieh Julie Chu, Yu-Chieh Lee, Wei-Ting Wong, Sheau-Long Lee, Jenn-Haung Lai, Ching-Liang Chu, Ling-Jun Ho, Hsiao-Wen Chiu, Yu-Juei Hsu, Cheng-Hsu Chen, Shuk-Man Ka, Ann Chen
BACKGROUND: Renal tubulointerstitial lesions (TILs), a key pathological hallmark for chronic kidney disease to progress to end-stage renal disease, feature renal tubular atrophy, interstitial mononuclear leukocyte infiltration and fibrosis in the kidney. Our study tested the renoprotective and therapeutic effects of compound K (CK), as described in our US patent (US7932057B2), on renal TILs using a mouse unilateral ureteral obstruction (UUO) model. METHODS: Renal pathology was performed and renal draining lymph nodes were subjected to flow cytometry analysis...
May 7, 2019: Nephrology, Dialysis, Transplantation
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Kazu Hamada-Ode, Yoshinori Taniguchi, Yoshiko Shimamura, Shimpei Fujimoto, Yoshio Terada
No abstract text is available yet for this article.
May 5, 2019: Nephrology, Dialysis, Transplantation
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Philippe Chauveau
No abstract text is available yet for this article.
May 5, 2019: Nephrology, Dialysis, Transplantation
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Mustafa Arici
No abstract text is available yet for this article.
May 5, 2019: Nephrology, Dialysis, Transplantation
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Sophie de Seigneux, Vasiliki Delitsikou, Pierre-Yves Martin
No abstract text is available yet for this article.
April 30, 2019: Nephrology, Dialysis, Transplantation
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Evgenia Preka, Marjolein Bonthuis, Jerome Harambat, Kitty J Jager, Jaap W Groothoff, Sergey Baiko, Aysun K Bayazit, Michael Boehm, Mirjana Cvetkovic, Vidar O Edvardsson, Svitlana Fomina, James G Heaf, Tuula Holtta, Eva Kis, Gabriel Kolvek, Linda Koster-Kamphuis, Elena A Molchanova, Marina Muňoz, Gisela Neto, Gregor Novljan, Nikoleta Printza, Emilija Sahpazova, Lisa Sartz, Manish D Sinha, Enrico Vidal, Karel Vondrak, Isabelle Vrillon, Lutz T Weber, Marcus Weitz, Ilona Zagozdzon, Constantinos J Stefanidis, Sevcan A Bakkaloglu
BACKGROUND: There is no consensus regarding the timing of dialysis therapy initiation for end-stage kidney disease (ESKD) in children. As studies investigating the association between timing of dialysis initiation and clinical outcomes are lacking, we aimed to study this relationship in a cohort of European children who started maintenance dialysis treatment. METHODS: We used data on 2963 children from 21 different countries included in the European Society of Pediatric Nephrology/European Renal Association-European Dialysis and Transplant Association Registry who started renal replacement therapy before 18 years of age between 2000 and 2014...
April 30, 2019: Nephrology, Dialysis, Transplantation
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A Lianne Messchendorp, Niek F Casteleijn, Esther Meijer, Ron T Gansevoort
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst formation, leading to growth in kidney volume and renal function decline. Although therapies have emerged, there is still an important unmet need for slowing the rate of disease progression in ADPKD. High intracellular levels of adenosine 3',5'-cyclic monophosphate (cAMP) are involved in cell proliferation and fluid secretion, resulting in cyst formation. Somatostatin (SST), a hormone that is involved in many cell processes, has the ability to inhibit intracellular cAMP production...
April 27, 2019: Nephrology, Dialysis, Transplantation
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Tessa K Novick, Morgan E Grams
No abstract text is available yet for this article.
April 26, 2019: Nephrology, Dialysis, Transplantation
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Jean-Baptiste de Freminville, Louis-Marie Vernier, Jérome Roumy, Frédéric Patat, Philippe Gatault, Bénédicte Sautenet, Elodie Bailly, Eloi Chevallier, Christelle Barbet, Hélène Longuet, Elodie Merieau, Christophe Baron, Matthias Buchler, Jean-Michel Halimi
BACKGROUND: Renal resistive index (RI) predicts mortality in renal transplant recipients, but we do not know whether this is true in diabetic patients. The objective of this study was to analyse the long-term predictive value of RI for death with a functioning graft (DWFG) in renal transplant recipients with or without pre-transplant diabetes. METHODS: We conducted a retrospective study in 1800 renal transplant recipients between 1985 and 2017 who were followed for up to 30 years (total observation period: 14 202 patient years)...
April 26, 2019: Nephrology, Dialysis, Transplantation
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Richard Haynes, Doreen Zhu, Parminder K Judge, William G Herrington, Philip A Kalra, Colin Baigent
Patients with chronic kidney disease are at increased risk of cardiovascular disease and this often manifests clinically like heart failure. Conversely, patients with heart failure frequently have reduced kidney function. The links between the kidneys and cardiovascular system are being elucidated, with blood pressure being a key risk factor. Patients with heart failure have benefitted from many trials which have now established a strong evidence based on which to base management. However, patients with advanced kidney disease have often been excluded from these trials...
April 26, 2019: Nephrology, Dialysis, Transplantation
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Katerina Damianaki, Joao Miguel Lourenco, Philippe Braconnier, Jean-Pierre Ghobril, Olivier Devuyst, Michel Burnier, Sebastien Lenglet, Marc Augsburger, Aurelien Thomas, Menno Pruijm
BACKGROUND: Zinc deficiency is commonly encountered in chronic kidney disease (CKD). The aims of this study were to assess whether zinc deficiency was related to increased renal excretion of zinc and to the progression of CKD. METHODS: Plasma and 24-h urinary zinc levels, urinary electrolytes and uromodulin were measured in 108 CKD patients and 81 individuals without CKD. Serum creatinine values were collected for 3 years to calculate the yearly change in estimated glomerular filtration rate (eGFR)...
April 21, 2019: Nephrology, Dialysis, Transplantation
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