journal
Journals Nephrology, Dialysis, Transpla...

Nephrology, Dialysis, Transplantation

https://read.qxmd.com/read/38754992/unlocking-the-untapped-potential-the-neglected-home-dialysis-assets-in-europe
#1
JOURNAL ARTICLE
Raymond Vanholder, Dieter Bach, Simon Davies, Patrik Finne, Sandip Mitra
No abstract text is available yet for this article.
May 16, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38754977/effects-of-sglt2-inhibitors-on-routine-urinary-analysis
#2
JOURNAL ARTICLE
Joris R Delanghe, Marc L De Buyzere, Sigurd E Delanghe, Marijn M Speeckaert
No abstract text is available yet for this article.
May 16, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38749569/plasma-symmetric-dimethylarginine-and-kidney-graft-function-in-kidney-transplant-recipients
#3
JOURNAL ARTICLE
Daan Kremer, Sovia Salamah, Dion Groothof, Adrian Post, Tim J Knobbe, António W Gomes Neto, Sarah Peterson, Marco van Londen, Murthy Yerramilli, Stefan P Berger, Firas F Alkaff, TransplantLines Investigators, Martin H de Borst, Stephan J L Bakker
No abstract text is available yet for this article.
May 15, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38744536/genetic-kidney-stones-disease-in-adults
#4
JOURNAL ARTICLE
Rebekka Stephan, Bernd Hoppe
No abstract text is available yet for this article.
May 14, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38730538/the-long-term-effects-of-dapagliflozin-in-chronic-kidney-disease-a-time-to-event-analysis
#5
JOURNAL ARTICLE
Phil McEwan, Peter D Gabb, Jason A Davis, Juan Jose Garcia Sanchez, C David Sjöström, Salvatore Barone, Pavlos Kashioulis, Mario Ouwens, Syd Cassimaty, Ricardo Correa-Rotter, Peter Rossing, David C Wheeler, Hiddo J L Heerspink
BACKGROUND AND HYPOTHESIS: Chronic kidney disease (CKD) presents a significant clinical and economic burden to healthcare systems worldwide, which increases considerably with progression towards kidney failure. The DAPA-CKD trial demonstrated that patients with or without type 2 diabetes (T2D) who were treated with dapagliflozin experienced slower progression of CKD versus placebo. Understanding the effect of long-term treatment with dapagliflozin on the timing of kidney failure beyond trial follow-up can assist informed decision-making by healthcare providers and patients...
May 10, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38724446/time-trends-in-preemptive-kidney-transplantation-in-europe-an-era-registry-study
#6
JOURNAL ARTICLE
Anneke Kramer, Rianne Boenink, Cynthia G Mercado Vergara, Samira Bell, Julia Kerschbaum, Olga L Rodríguez Arévalo, Auxiliadora Mazuecos, Aiko P J de Vries, Anna V Reisæter, Esther H S Wong, Torbjörn Lundgren, María O Valentin, Flor Angel Ordoñez Alvarez, Edoardo Melilli, Patrik Finne, Mårten Segelmark, Cécile Couchoud, Søren S Sørensen, Pietro Manuel Ferraro, Miha Arnol, Mustafa Arici, Alberto Ortiz, Kitty J Jager, Daniel Abramowicz, Vianda S Stel, Rachel Hellemans
BACKGROUND: Preemptive kidney transplantation has better outcomes when compared to transplantation after dialysis. We aimed to examine trends in preemptive kidney transplantation between 2000 and 2019 in Europe and to provide an overview of associated policies, barriers and initiatives. METHODS: Adult patients from 12 European countries who received a preemptive kidney transplant were included. The representatives of the registries providing these data were questioned on the policies, barriers and initiatives around preemptive kidney transplantation...
May 9, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38724443/why-race-free-egfr-formulas-are-important-for-everyone
#7
JOURNAL ARTICLE
Roy O Mathew
No abstract text is available yet for this article.
May 9, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38710537/low-dialysate-sodium-and-48-h-ambulatory-blood-pressure-in-patients-with-intradialytic-hypertension-a-randomized-crossover-study
#8
JOURNAL ARTICLE
Fotini Iatridi, Konstantinos Malandris, Robert Ekart, Efstathios Xagas, Antonios Karpetas, Marieta P Theodorakopoulou, Artemios Karagiannidis, Areti Georgiou, Aikaterini Papagianni, Pantelis Sarafidis
BACKGROUND AND HYPOTHESIS: Intradialytic-hypertension (IDH) is associated with increased risk for cardiovascular events and mortality. Patients with IDH exhibit higher 48-h blood pressure (BP) levels than patients without this condition. Volume and sodium excess are considered a major factor contributing in the development of this phenomenon. This study evaluated the effect of low (137mEq/L) compared to standard (140mEq/L) dialysate sodium concentration on 48-h BP in patients with IDH...
May 6, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38697934/kidney-doppler-ultrasonography-in-critical-care-nephrology
#9
JOURNAL ARTICLE
Francesco Corradi, Max Bell, Silvia De Rosa
Color pulsed-wave Doppler ultrasound (CPWD-US) emerges as a pivotal tool in intensive care units (ICUs) for diagnosing acute kidney injury (AKI) swiftly and non-invasively. Its bedside accessibility allows for rapid assessments, making it a primary imaging modality for AKI characterization. Furthermore, CPWD-US serves as a guiding instrument for key diagnostic-interventional procedures such as renal needle biopsy and percutaneous nephrostomy, while also facilitating therapy response monitoring and AKI progression tracking...
May 2, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38688876/albuminuria-predicts-kidney-events-in-iga-nephropathy
#10
JOURNAL ARTICLE
Anne-Laure Faucon, Sigrid Lundberg, Stefania Lando, Julia Wijkström, Mårten Segelmark, Marie Evans, Juan-Jesús Carrero
BACKGROUND & HYPOTHESIS: KDIGO recommends proteinuria <1 g/d as a treatment target in patients with immunoglobulin A nephropathy (IgAN) because of high-risk of progression to kidney failure. However, long-term kidney outcomes in patients with low-grade proteinuria remain insufficiently studied. METHODS: We enrolled patients with biopsy-proven primary IgAN from the Swedish Renal Registry and analyzed associations between urine albumin-to-creatinine ratio (uACR, in categories < 0...
April 30, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38688873/microscopic-hematuria-in-c3g-and-ic-mpgn
#11
JOURNAL ARTICLE
Fernando Caravaca-Fontán, Manuel Praga
No abstract text is available yet for this article.
April 30, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38688870/redefining-the-concept-of-residual-renal-function-with-kidney-sodium-mri-a-pilot-study
#12
JOURNAL ARTICLE
Sandrine Lemoine, Alireza Akbari, Gary Brahm, Justin Dorie, Tanya Tamasi, Jarrin Penny, Christopher W McIntyre
RATIONALE & OBJECTIVE: The concept of residual kidney function (RKF) is exclusively based upon urine volume and small solute clearance, making RKF challenging to assess in clinical practice. The aim of this study was to test the technical feasibility of obtaining useable 23Na-MRI kidney images in hemodialysis (HD) participants. STUDY DESIGN: We conducted an exploratory prospective study to quantify the cortico-medullary sodium gradient in healthy and HD participants...
April 30, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38688869/cognitive-deficits-associate-with-cerebral-hypoxia-during-hemodialysis
#13
JOURNAL ARTICLE
Dawn F Wolfgram, Wesley T Richerson, Anne M Murray, Brian D Schmit
No abstract text is available yet for this article.
April 30, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38684483/migrants-kidney-sales-fortress-europe-and-the-transplant-community-a-call-for-awareness
#14
JOURNAL ARTICLE
Zanna Ramaekers, Marlies E J Reinders, Richard Staring, Frederike Ambagtsheer
No abstract text is available yet for this article.
April 29, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38684469/live-donor-kidney-transplant-outcome-prediction-l-top-using-artificial-intelligence
#15
JOURNAL ARTICLE
Hatem Ali, Mahmoud Mohammed, Miklos Z Molnar, Tibor Fülöp, Bernard Burke, Sunil Shroff, Arun Shroff, David Briggs, Nithya Krishnan
Outcome prediction for live-donor kidney transplantation improves clinical and patient decisions and donor selection. However, the concurrently used models are of limited discriminative or calibration power and there is a critical need to improve the selection process. We aimed to assess the value of various artificial intelligence (AI) algorithms to improve the risk stratification index. We evaluated pre-transplant variables among 66 914 live-donor kidney transplants (performed between 01/12/2007-01/06/2021) from the United Network of Organ Sharing database, randomized into training (80%) and test (20%) sets...
April 29, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38684468/ferroptosis-biology
#16
JOURNAL ARTICLE
Tobias Seibt, Adam Wahida, Konrad Hoeft, Stephan Kemmner, Andreas Linkermann, Eikan Mishima, Marcus Conrad
Ferroptosis is a regulated cell death modality triggered by iron-dependent lipid peroxidation. Ferroptosis plays a causal role in the pathophysiology of various diseases, making it a promising therapeutic target. Unlike all other cell death modalities dependent on distinct signaling cues, ferroptosis occurs when cellular antioxidative defense mechanisms fail to suppress the oxidative destruction of cellular membranes, eventually leading to cell membrane rupture. Physiologically, only two such surveillance systems are known to efficiently prevent the lipid peroxidation chain reaction by reducing (phospho)lipid hydroperoxides to their corresponding alcohols or by reducing radicals in phospholipid bilayers, thus maintaining the integrity of lipid membranes...
April 29, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38678004/a-note-on-performance-metrics-for-the-kidney-failure-risk-equation
#17
JOURNAL ARTICLE
Oskar Ålund, Robert Unwin, Benjamin Challis, Philip A Kalra, Maarten W Taal, David C Wheeler, Simon D S Fraser, Paul Cockwell, Magnus Söderberg
No abstract text is available yet for this article.
April 27, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38664060/fhl2-in-arterial-medial-calcification-in-chronic-kidney-disease
#18
JOURNAL ARTICLE
Yuan-Ru Liao, Yu-Cheng Tsai, Tsung-Han Hsieh, Ming-Tsun Tsai, Feng-Yen Lin, Shing-Jong Lin, Chih-Ching Lin, Hou-Yu Chiang, Pao-Hsien Chu, Szu-Yuan Li
BACKGROUND AND HYPOTHESIS: Arterial medial calcification (AMC) is a common complication in individuals with chronic kidney disease (CKD), which can lead to cardiovascular morbidity and mortality. The progression of AMC is controlled by a key transcription factor called runt-related transcription factor 2 (RUNX2), which induces vascular smooth muscle cells (VSMCs) transdifferentiation into a osteogenic phenotype. However, RUNX2 has not been targeted for therapy due to its essential role in bone development...
April 25, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38664006/interactive-exploration-of-adverse-events-and-multimorbidity-in-ckd
#19
JOURNAL ARTICLE
Inga Steinbrenner, Fruzsina Kotsis, Robin Kosch, Heike Meiselbach, Barbara Bärthlein, Helena Stockmann, Jan Lipovsek, Helena U Zacharias, Michael Altenbuchinger, Thomas Dienemann, Monika Wytopil, Helena Bächle, Claudia Sommerer, Stephanie Titze, Anke Weigel, Hansi Weissensteiner, Sebastian Schönherr, Lukas Forer, Nadine S Kurz, Jan Menne, Georg Schlieper, Markus P Schneider, Elke Schäffner, Jan T Kielstein, Thomas Sitter, Jürgen Floege, Christoph Wanner, Florian Kronenberg, Anna Köttgen, Martin Busch, Vera Krane, Matthias Schmid, Kai-Uwe Eckardt, Ulla T Schultheiss
BACKGROUND AND HYPOTHESIS: Persons with chronic kidney disease (CKD) are at increased risk of adverse events, early mortality, and multimorbidity. A detailed overview of adverse event types and rates from a large CKD cohort under regular nephrological care is missing. We generated an interactive tool to enable exploration of adverse events and their combinations in the prospective, observational German CKD (GCKD) study. METHODS: The GCKD study enrolled 5217 participants under regular nephrological care with an estimated glomerular filtration rate of 30-60 or >60 mL/min/1...
April 25, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38658194/carfilzomib-associated-thrombotic-microangiopathy-clinical-features-and-outcomes
#20
JOURNAL ARTICLE
Adrien Joseph, Stéphanie Harel, Laurent Mesnard, Cédric Rafat, Silène Knapp, Anne Rumpler, Carole Philipponnet, Christophe Barba, Jean-Michel Rebibou, David Buob, Alexandre Hertig, Jacques Vargaftig, Jean-Michel Halimi, Bertrand Arnulf, Anne-Sophie Bretaud, Bérangère Joly, Steven Grangé, Paul Coppo
BACKGROUND AND HYPOTHESIS: Carfilzomib, a new proteasome inhibitor indicated for patients with relapsed/refractory myeloma, has been associated with cases of thrombotic microangiopathy (CFZ-TMA). The role of variants in the complement alternative pathway and therapeutic potential of complement blockade with eculizumab remain to be determined. METHODS: We report 37 cases of CFZ-TMA recorded in the French reference center for TMA with their clinical characteristics, genetic analysis and outcome according to treatments...
April 24, 2024: Nephrology, Dialysis, Transplantation
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