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Timna Agur, Naomi Ben-Dor, Shira Goldman, Shelly Lichtenberg, Michal Herman-Edelstein, Dafna Yahav, Benaya Rozen-Zvi, Boris Zingerman
No abstract text is available yet for this article.
April 11, 2021: Nephrology, Dialysis, Transplantation
#2
Sehoon Park, Soojin Lee, Yaerim Kim, Yeonhee Lee, Min Woo Kang, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
BACKGROUND: An investigation for the causality of the effects of physical activity and specific sedentary activities on kidney function in the general population is warranted. METHODS: In this observational cohort study, first, the clinical associations of the prevalence of stages 3-5 chronic kidney disease (CKD) and the eGFR with physical activity, determined by self-report or objective wrist-band accelerometer results, and sedentary activities (watching television, using a computer, and driving) were investigated in 329,758 UK Biobank participants...
April 7, 2021: Nephrology, Dialysis, Transplantation
#3
Selcan Demir, Bora Gülhan, Seza Özen, Kübra Çeleğen, Ezgi Deniz Batu, Nesrin Taş, Diclehan Orhan, Yelda Bilginer, Ali Düzova, Fatih Ozaltin, Rezan Topaloğlu
BACKGROUND: Childhood-onset systemic lupus erythematosus (SLE) is more severe than adult-onset disease, including more frequent kidney involvement. This study aimed to investigate baseline clinical features, treatment modalities, short- and long-term renal outcomes of pediatric patients with lupus nephritis (LN). MATERIALS AND METHODS: This study enrolled 53 LN patients out of 102 childhood-onset SLE patients followed at Hacettepe University between 2000-2020. The demographic and clinical data were reviewed retrospectively from the medical charts and electronic records...
April 7, 2021: Nephrology, Dialysis, Transplantation
#4
Eva Pella, Afroditi Boutou, Aristi Boulmpou, Christodoulos E Papadopoulos, Aikaterini Papagianni, Pantelis Sarafidis
Chronic kidney disease (CKD), especially end-stage kidney disease (ESKD), is associated with increased risk for cardiovascular events and all-cause mortality. Exercise intolerance as well as reduced cardiovascular reserve are extremely common in patients with CKD. Cardiopulmonary exercise testing (CPET) is a non-invasive, dynamic technique that provides an integrative evaluation of cardiovascular, pulmonary, neuropsychological and metabolic function during maximal or submaximal exercise, allowing the evaluation of functional reserves of these systems...
April 6, 2021: Nephrology, Dialysis, Transplantation
#5
Hae Hyuk Jung
BACKGROUND: The treatment BP target in CKD remains unclear, and whether the benefit of intensive BP-lowering is comparable between CKD and non-CKD patients is debated. METHODS: Using the Korean National Health Information Database, 359,492 CKD patients who had received antihypertensives regularly were identified from 12.1 million participants of nationwide health screening. The composite risk of major cardiovascular events, kidney failure, and all-cause mortality was assessed according to timely-averaged, on-treatment systolic BP...
April 3, 2021: Nephrology, Dialysis, Transplantation
#6
Rianne W de Jong, Kitty J Jager, Raymond C Vanholder, Cécile Couchoud, Mark Murphy, Axel Rahmel, Ziad A Massy, Vianda S Stel
No abstract text is available yet for this article.
March 31, 2021: Nephrology, Dialysis, Transplantation
#7
Camille André, Gabriel Choukroun, Youssef Bennis, Said Kamel, Anne Sophie Lemaire-Hurtel, Kamel Masmoudi, Sandra Bodeau, Sophie Liabeuf
BACKGROUND: The uremic toxins that accumulate with as renal function deteriorates can potentially affect drug pharmacokinetics. The study's objective was to determine whether plasma concentrations of certain uremic toxins were correlated with blood concentrations of two immunosuppressants. METHODS: DRUGTOX was a cross-sectional study of 403 adult patients followed up after kidney transplantation and who had undergone therapeutic drug monitoring (TDM) of calcineurin inhibitors (tacrolimus or cyclosporin) between August 2019, and March 2020...
March 30, 2021: Nephrology, Dialysis, Transplantation
#8
Fernando Caravaca-Fontán, Montserrat Díaz-Encarnación, Virginia Cabello, Gema Ariceta, Luis F Quintana, Helena Marco, Xoana Barros, Natalia Ramos, Nuria Rodríguez-Mendiola, Sonia Cruz, Gema Fernández-Juárez, Adela Rodríguez, Ana Pérez de José, Cristina Rabasco, Raquel Rodado, Loreto Fernández, Vanessa Pérez Gómez, Ana Ávila, Luis Bravo, Natalia Espinosa, Natalia Allende, Maria Dolores Sanchez de la Nieta, Eva Rodríguez, Teresa Olea, Marta Melgosa, Ana Huerta, Rosa Miquel, Carmen Mon, Gloria Fraga, Alberto de Lorenzo, Juliana Draibe, Marta Cano-Megías, Fayna González, Amir Shabaka, Maria Esperanza López-Rubio, María Ángeles Fenollosa, Luis Martín-Penagos, Iara Da Silva, Juana Alonso Titos, Santiago Rodríguez de Córdoba, Elena Goicoechea de Jorge, Manuel Praga
INTRODUCTION: The association between a change in proteinuria over time and its impact in kidney prognosis has not been analyzed in C3 glomerulopathy. This study aims to investigate the association between the longitudinal change in proteinuria and the risk of kidney failure. METHODS: Retrospective, multicenter observational cohort study in 35 nephrology departments belonging to the Spanish Group for the Study of Glomerular Diseases (GLOSEN). Patients diagnosed with C3 glomerulopathy between 1995 and 2020 were enrolled...
March 29, 2021: Nephrology, Dialysis, Transplantation
#9
Guy Decaux
No abstract text is available yet for this article.
March 27, 2021: Nephrology, Dialysis, Transplantation
#10
Anna Pisano, Francesca Mallamaci, Graziella D'Arrigo, Davide Bolignano, Gregoire Wuerzner, Alberto Ortiz, Michel Burnier, Nada Kanaan, Pantelis Sarafidis, Alexandre Persu, Charles J Ferro, Charalampos Loutradis, Ioannis N Boletis, Gérard London, Jean-Michel Halimi, Bénédicte Sautenet, Patrick Rossignol, Liffert Vogt, Carmine Zoccali
BACKGROUND: Sparse studies show that ambulatory blood pressure monitoring (ABPM) is superior to office BP (oBP) measurements to predict target organ damage and cardiovascular (CV) events in kidney transplant recipients (KTRs). We performed a systematic review aimed at determining the potential associations between BP recordings by different methods and renal and CV outcomes in this population. METHODS: Major medical databases were searched for studies enrolling adult KTRs undergoing 24h ABPM compared to office or home BP measurements...
March 25, 2021: Nephrology, Dialysis, Transplantation
#11
Reuben William Horace, Mary Roberts, Theresa I Shireman, Basma Merhi, Paul Jacques, Andrew G Bostom, Simin Liu, Charles B Eaton
BACKGROUND: The cholesterol content of circulating triglyceride-rich lipoproteins is characterized as remnant cholesterol, although little is known about its role in the development of CVD outcomes, all-cause mortality, or transplant failure in kidney transplant recipients. Our primary aim was to investigate the prospective association of remnant cholesterol and the risk of CVD events in renal transplant recipients with secondary aims evaluating remnant cholesterol and renal graft failure and all-cause mortality among participants in the Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) trial...
March 24, 2021: Nephrology, Dialysis, Transplantation
#12
Peter Janssens, Jean-Paul Decuypere, Bert Bammens, Catherine Llorens-Cortes, Rudi Vennekens, Djalila Mekahli
The apelinergic system (AS) is a novel pleiotropic system with an essential role in renal and cardiovascular physiology and disease, including water homeostasis and blood pressure regulation. It consists of two highly conserved peptide ligands, apelin and apela, and a G-protein-coupled apelin receptor. The two ligands have many isoforms and a short half-life, and exert both similar and divergent effects. Vasopressin, apelin and their receptors colocalize in hypothalamic regions essential for body fluid homeostasis and interact at the central and renal levels to regulate water homeostasis and diuresis in inverse directions...
March 21, 2021: Nephrology, Dialysis, Transplantation
#13
Chenyu Li, Hans-Joachim Anders
No abstract text is available yet for this article.
March 21, 2021: Nephrology, Dialysis, Transplantation
#14
Ajay K Singh, Allison Blackorby, Borut Cizman, Kevin Carroll, Alexander R Cobitz, Rich Davies, Vivekanand Jha, Kirsten L Johansen, Renato D Lopes, Lata Kler, Iain C Macdougall, John McMurray, Amy M Meadowcroft, Gregorio T Obrador, Vlado Perkovic, Scott Solomon, Christoph Wanner, Sushrut S Waikar, David C Wheeler, Andrzej Wiecek
BACKGROUND: The Anemia Studies in chronic kidney disease (CKD): Erythropoiesis via a Novel prolyl hydroxylase inhibitor (PHI) Daprodustat-Dialysis (ASCEND-D) trial will test the hypothesis that daprodustat is non-inferior to comparator epoetin alfa or darbepoetin alfa for two co-primary endpoints: haemoglobin efficacy and cardiovascular safety. METHODS: We report the trial design, key demographic, clinical, and laboratory findings, and baseline therapies of 2964 patients randomised in the open-label (sponsor-blinded) active-controlled, parallel-group, randomised ASCEND-D clinical trial...
March 21, 2021: Nephrology, Dialysis, Transplantation
#15
Laurent Bitker, Lisa Toh, Intissar Bittar, Glenn Eastwood, Rinaldo Bellomo
No abstract text is available yet for this article.
March 18, 2021: Nephrology, Dialysis, Transplantation
#16
Jamie S Hirsch, Nupur N Uppal, Purva Sharma, Yuriy Khanin, Hitesh H Shah, Deepa A Malieckal, Alessandro Bellucci, Mala Sachdeva, Helbert Rondon-Berrios, Kenar D Jhaveri, Steven Fishbane, Jia H Ng
No abstract text is available yet for this article.
March 16, 2021: Nephrology, Dialysis, Transplantation
#17
Suzanne Forbes, Maria Davari, Sahana Gnanasampanthan, Noam Roth, Gregor Young, Ravindra Rajakariar, Andrea Cove-Smith, Muhammed Magdi Yaqoob, Teresa Cutino-Moguel, Viyaasan Mahalingasivam, Kieran McCafferty
BACKGROUND: Haemodialysis patients are extremely vulnerable to COVID-19. Their immune response after infection is unclear. We have found high seroconversion rates in this population with 95% developing antibodies. It is unclear if and how long these antibodies persist. Here we investigate this with serial antibody testing. METHODS: We identified haemodialysis patients who had confirmed SARS-CoV-2 between March-May 2020 and measured monthly antibodies (IgG/IgM) in those who survived...
March 15, 2021: Nephrology, Dialysis, Transplantation
#18
Ben Storey, Matt Bottomley, Salim Hammad, Allie Thornley, Lucinda Barrett, Oliver O'Sullivan, Katherine Bull
No abstract text is available yet for this article.
March 9, 2021: Nephrology, Dialysis, Transplantation
#19
Andreas Kronbichler, Hans-Joachim Anders, Gema Maria Fernandez-Juárez, Jürgen Floege, Dimitrios Goumenos, Mårten Segelmark, Vladimir Tesar, Kultigin Turkmen, Cees van Kooten, Annette Bruchfeld
Coronavirus Disease 19 (COVID-19) vaccine platforms are becoming available and are the most promising strategy to curb the spread of SARS-CoV-2 infections. However, numerous uncertainties exist regarding the pros and cons of vaccination, especially in patients with (immune-mediated) kidney diseases on immunosuppressive drugs. Here, members of the Immunonephrology Working Group (IWG) of the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) discuss thirteen frequently-asked questions regarding safety and efficacy of the most promising vaccine candidates...
March 9, 2021: Nephrology, Dialysis, Transplantation
#20
Mark Canney, Manish M Sood, Gregory L Hundemer
No abstract text is available yet for this article.
March 5, 2021: Nephrology, Dialysis, Transplantation
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