Journals Nephrology, Dialysis, Transpla...

Nephrology, Dialysis, Transplantation
Luisa Süfling, Daniel Greinert, Matthias Girndt
BACKGROUND: Vitamin K antagonists (VKA) are still in use for oral anticoagulation, not all indications allow their replacement by direct oral anticoagulants (DOAC). Although formal dose reduction is not required in patients with impaired kidney function, case reports indicate that acute kidney injury (AKI) might be associated with derailment of VKA therapy. METHODS: The study retrospectively collected patients from a tertiary nephrology care center who experienced AKI while being treated with VKA...
January 18, 2021: Nephrology, Dialysis, Transplantation
Christoph Nowak, Johan Ärnlöv
No abstract text is available yet for this article.
January 18, 2021: Nephrology, Dialysis, Transplantation
Luke Pickup, Charalampos Loutradis, Jonathan P Law, Julia J Arnold, Indranil Dasgupta, Pantelis Sarafidis, Jonathan N Townend, Paul Cockwell, Charles J Ferro
BACKGROUND: Acute kidney injury (AKI) in hospital-admitted patients is a common complication associated with increased mortality. The diagnosis of AKI relies on the ascertainment of peak increase in serum creatinine (SCr). This study evaluated the incidence of AKI using the increase from mean 7-365 days pre-admission (AKIpre) and admission (AKIadm) SCr levels, and examined the associations of AKI and changes in SCr levels with all-cause mortality. METHODS: A total of 2436 patients admitted to a tertiary hospital were recruited and followed-up for a median of 47...
January 17, 2021: Nephrology, Dialysis, Transplantation
Rupert W Major, David Shepherd, James F Medcalf, Gang Xu, Laura J Gray, Nigel J Brunskill
BACKGROUND: South Asian (SA) individuals are more likely to develop end-stage renal disease (ESRD), but how chronic kidney disease (CKD) differs in relation to demographics, comorbidities and outcomes has not been studied. We aimed to study differences in SA individuals with CKD compared with White individuals. METHODS: This was an observational CKD cohort comparing SA with White individuals. Inclusion criteria were ≥18 years of age and two or more Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFRs <60 mL/min/1...
January 13, 2021: Nephrology, Dialysis, Transplantation
Steven Law, Oliver Cohen, Helen J Lachmann, Tamer Rezk, Janet A Gilbertson, Dorota Rowczenio, Ashutosh D Wechalekar, Philip N Hawkins, Reza Motallebzadeh, Julian D Gillmore
BACKGROUND: Outcomes after renal transplantation have traditionally been poor in systemic amyloid A (AA) amyloidosis and systemic light chain (AL) amyloidosis, with high mortality and frequent recurrent disease. We sought to compare outcomes with matched transplant recipients with autosomal dominant polycystic kidney disease (ADPKD) and diabetic nephropathy (DN), and identify factors predictive of outcomes. METHODS: We performed a retrospective cohort study of 51 systemic AL and 48 systemic AA amyloidosis patients undergoing renal transplantation...
January 13, 2021: Nephrology, Dialysis, Transplantation
Jonas Garessus, Wendy Brito, Nicolas Loncle, Anna Vanelli, Marielle Hendriks-Balk, Grégoire Wuerzner, Antoine Schneider, Michel Burnier, Menno Pruijm
BACKGROUND: Disturbances in renal microcirculation play an important role in the pathophysiology of chronic kidney disease (CKD), but the lack of easy accessible techniques hampers our understanding of the regulation of the renal microcirculation in humans. We assessed whether contrast-enhanced ultrasonography (CEUS) can identify differences in cortical perfusion and alterations induced by different dietary salt intakes in CKD patients and controls. METHODS: Participants underwent CEUS twice: once after 5 days of high salt intake (HS), and again after 5 days of low salt diet (LS)...
January 11, 2021: Nephrology, Dialysis, Transplantation
Anirudh Rao, Stephanie J MacNeill, Moniek W M van de Luijtgaarden, Nicholas C Chesnaye, Christiane Drechsler, Chistoph Wanner, Claudia Torino, Maurizio Postorino, Maciej Szymczak, Marie Evans, Friedo W Dekker, Kitty J Jager, Yoav Ben-Shlomo, Fergus J Caskey
BACKGROUND: Cohort studies are among the most robust of observational studies but have issues with external validity. This study assesses threats to external validity (generalisability) in the European QUALity (EQUAL) study, a cohort study of people over 65 years with stage 4/5 chronic kidney disease. METHODS: Patients meeting the EQUAL inclusion criteria were identified in The Health Improvement Network database and stratified into those attending renal units (secondary care cohort-SCC) and not (primary care cohort-PCC)...
January 11, 2021: Nephrology, Dialysis, Transplantation
Laura Martínez-Arias, Sara Panizo, Cristina Alonso-Montes, Julia Martín-Vírgala, Beatriz Martín-Carro, Sara Fernández-Villabrille, Carmen García Gil-Albert, Carmen Palomo-Antequera, José Luis Fernández-Martín, María Piedad Ruiz-Torres, Adriana S Dusso, Natalia Carrillo-López, Jorge B Cannata-Andía, Manuel Naves-Díaz
BACKGROUND: In chronic kidney Disease (CKD) the activation of the renin-angiotensin-aldosterone system and renal inflammation stimulate renal fibrosis and the progression to end-stage renal disease. The low levels of vitamin D receptor (VDR) and its activators (VDRAs) contribute to worsen secondary hyperparathyroidism and renal fibrosis. METHODS: The 7/8 nephrectomy model of experimental chronic renal failure (CRF) was used to examine the antifibrotic effects of treatment with two VDRAs (paricalcitol and calcitriol at equivalent doses (3/1 dose ratio) during 4 weeks...
January 8, 2021: Nephrology, Dialysis, Transplantation
Anja Pfau, Danica Grujic, Mira T Keddis, Annamaria T Kausz, John Lieske, Felix Knauf
No abstract text is available yet for this article.
January 8, 2021: Nephrology, Dialysis, Transplantation
Sivakumar Sridharan, Enric Vilar, Sivaramakrishnan Ramanarayanan, Andrew Davenport, Ken Farrington
BACKGROUND: Physical activity (PA) levels are low in patients with advanced chronic kidney disease (CKD), and associate with increased morbidity and mortality. Reliable tools to assess PA in CKD are scarce. We aimed to develop and validate a novel PA questionnaire for use in CKD (CKD-PAQ). METHODS: In phase 1, a prototype questionnaire was developed based on the validated Recent Physical Activity Questionnaire (RPAQ). Structured feedback on item relevance and clarity was obtained from 40 CKD patients...
January 8, 2021: Nephrology, Dialysis, Transplantation
Nizar Joher, Clément Gosset, Dominique Guerrot, Evangeline Pillebout, Aurélie Hummel, Jean-Jacques Boffa, Stanislas Faguer, Marion Rabant, Sarah Higgins, Anissa Moktefi, Yahsou Delmas, Alexandre Karras, Nathanaël Lapidus, Aurélien Amiot, Vincent Audard, Khalil El Karoui
BACKGROUND: Little is known about clinical characteristics and kidney outcome in patients with biopsy-proven immunoglobulin A nephropathy (IgAN) in a context of inflammatory bowel disease (IBD). METHODS: We conducted a retrospective multicenter study with centralized histological review, to analyze the presentation, therapeutic management and outcome of 24 patients suffering from IBD associated IgAN relative to a cohort of 134 patients with primary IgAN without IBD...
January 8, 2021: Nephrology, Dialysis, Transplantation
Rachel G Armani, Aluizio B Carvalho, Christiane I Ramos, Valeria Hong, Luiz A Bortolotto, Jose Luiz Cassiolato, Natacha F Oliveira, Zuzana Cieslarova, Claudimir L do Lago, Aline Klassen, Lilian Cuppari, Dominic S Raj, Maria Eugênia F Canziani
BACKGROUND: Microbiota-derived uremic toxins have been associated with inflammation that could corroborate with endothelial dysfunction (ED) and increase cardiovascular risk in patients with chronic kidney disease (CKD). This trial aimed to evaluate the effect of the prebiotic fructooligosaccharide (FOS) on endothelial function and arterial stiffness in nondialysis CKD patients. METHODS: In a double-blind controlled trial, 46 nondiabetic CKD patients were randomized to receive 12 g/day of FOS or placebo (maltodextrin) for 3 months...
January 7, 2021: Nephrology, Dialysis, Transplantation
Hiroki Yamaguchi, Shin Goto, Nao Takahashi, Masafumi Tsuchida, Hirofumi Watanabe, Suguru Yamamoto, Yoshikatsu Kaneko, Koichi Higashi, Hiroshi Mori, Yukio Nakamura, Arata Horii, Ken Kurokawa, Ichiei Narita
No abstract text is available yet for this article.
January 4, 2021: Nephrology, Dialysis, Transplantation
Charles J Blijdorp, David Severs, Usha M Musterd-Bhaggoe, Ronald T Gansevoort, Robert Zietse, Ewout J Hoorn
BACKGROUND: Metabolic acidosis accelerates progression of chronic kidney disease, but whether this is also true for autosomal dominant polycystic kidney disease (ADPKD) is unknown. METHODS: Patients with ADPKD from the DIPAK (Developing Interventions to halt Progression of ADPKD) trial were included [n = 296, estimated glomerular filtration rate (eGFR) 50 ± 11 mL/min/1.73 m2, 2.5 years follow-up]. Outcomes were worsening kidney function (30% decrease in eGFR or kidney failure), annual eGFR change and height-adjusted total kidney and liver volumes (htTKV and htTLV)...
December 30, 2020: Nephrology, Dialysis, Transplantation
Anique D Ter Braake, Marc G Vervloet, Jeroen H F de Baaij, Joost G J Hoenderop
Vascular calcification is a prognostic marker for cardiovascular mortality in chronic kidney disease (CKD) patients. In these patients, magnesium balance is disturbed, mainly due to limited ultrafiltration of this mineral, changes in dietary intake and the use of diuretics. Observational studies in dialysis patients report that a higher blood magnesium concentration is associated with reduced risk to develop vascular calcification. Magnesium prevents osteogenic vascular smooth muscle cell transdifferentiation in in vitro and in vivo models...
December 29, 2020: Nephrology, Dialysis, Transplantation
Andreas Kronbichler, Jae Il Shin, Chia-Shi Wang, Wladimir M Szpirt, Mårten Segelmark, Vladimir Tesar
Plasma exchange (PLEX) is capable of removing significant amounts of circulating antibodies. In anti-neutrophil cytoplasmic antibody-associated vasculitis, PLEX was reserved for patients with severe presentation forms such as rapidly progressive glomerulonephritis and pulmonary haemorrhage. The Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis (PEXIVAS) trial included all comers with a glomerular filtration rate <50 mL/min/1.73 m2 and thus aimed to answer the question of whether PLEX is an option for patients with no relevant kidney function impairment or not...
December 29, 2020: Nephrology, Dialysis, Transplantation
Ulrich Specks, Lynn A Fussner, Rodrigo Cartin-Ceba, Marta Casal Moura, Ladan Zand, Fernando C Fervenza
Advances in the diagnosis and treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis have led to continued improvement in survival and prognosis over the course of the last 4 decades. Nevertheless, the most acute and severe disease manifestations, including severe kidney disease and alveolar hemorrhage, continue to be associated with increased early mortality from disease activity or treatment complications as well as risk for the development of end-stage kidney disease (ESKD), which in turn directly affects the overall prognosis of ANCA-associated vasculitis...
December 29, 2020: Nephrology, Dialysis, Transplantation
Harish Seethapathy, Nifasha Rusibamayila, Donald F Chute, Meghan Lee, Ian Strohbehn, Leyre Zubiri, Alexander T Faje, Kerry L Reynolds, Kenar D Jhaveri, Meghan E Sise
BACKGROUND: Hyponatremia due to endocrinopathies such as adrenal insufficiency and hypothyroidism has been reported in patients receiving immune checkpoint inhibitors (ICIs). We determined the risk and predictors of hyponatremia and other electrolyte abnormalities in a 'real-world' sample of patients receiving ICIs to treat advanced malignancies. METHODS: This was a retrospective observational study of all patients who received ICIs from a single cancer center between 2011 and 2018...
December 29, 2020: Nephrology, Dialysis, Transplantation
Melissa Nataatmadja, Nicole Evangelidis, Karine E Manera, Yeoungjee Cho, David W Johnson, Jonathan C Craig, Amanda Baumgart, Camilla S Hanson, Jenny Shen, Chandana Guha, Nicole Scholes-Robertson, Allison Tong
BACKGROUND: Diminished mental health is associated with increased morbidity and mortality and may contribute to loss of independence and motivation in patients receiving dialysis and their caregivers. Increased understanding of the patient perspective on triggers, impacts and strategies for managing mental health may inform ways to address mental health conditions in this population. METHODS: A secondary thematic analysis was undertaken using data from the Standardized Outcomes in Nephrology (SONG)-Hemodialysis and SONG-Peritoneal Dialysis projects...
December 29, 2020: Nephrology, Dialysis, Transplantation
Hassan Izzedine, Thibaud Chazal, Rimda Wanchoo, Kenar D Jhaveri
Immune checkpoint inhibitors (CPIs) have recently become a cornerstone for the treatment of different advanced cancers. These drugs have the ability to reactivate the immune system against tumour cells but can also trigger a myriad of side effects, termed immune-related adverse events (irAEs). Although there are numerous reports of CPI-related endocrinopathies, hypercalcaemia as a suspected irAE is not well documented. The mechanisms of CPI hypercalcaemia are not clearly established. However, in our review, four distinct causes emerged: endocrine disease-related, sarcoid-like granuloma, humoral hypercalcaemia due to parathyroid-related hormone and hyperprogressive disease following CPI initiation...
December 29, 2020: Nephrology, Dialysis, Transplantation
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