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JOURNAL ARTICLE
Kunihiro Yamagata
No abstract text is available yet for this article.
November 28, 2022: Nephrology, Dialysis, Transplantation
#2
JOURNAL ARTICLE
Giovanni Gambaro, Lazaros Tzelves, Andreas Skolarikos, Mehmet Kanbay, Alberto Ortiz, Mario Cozzolino
No abstract text is available yet for this article.
November 28, 2022: Nephrology, Dialysis, Transplantation
#3
JOURNAL ARTICLE
Carla Burballa, Gerard Cantero-Recasens, Larisa Prikhodina, Francesca Lugani, Karlpeter Schlingmann, Petr V Ananin, Martine Besouw, Detlef Bockenhauer, Leire Madariaga, Aurelia Bertholet-Thomas, Francesca Taroni, Mattia Parolin, Peter Conlon, Dorella Delprete, Dominique Chauveau, Linda Koster-Kamphuis, Marc Fila, Andrea Pasini, Isabel Castro, Giacomo Colussi, Marta Gil, Barian Mohidin, Tanja Wlodkowski, Franz Schaefer, Gema Ariceta
BACKGROUND: Dent's disease type 1 (DD1) is a rare X-linked nephropathy caused by CLCN5 mutations, characterized by proximal tubule dysfunction, including low-molecular-weight proteinuria (LMWP), hypercalciuria, nephrolithiasis-nephrocalcinosis, progressive chronic kidney disease (CKD) and kidney failure (KF). Current management is symptomatic and does not prevent disease progression. Here we describe the contemporary DD1 picture across Europe to highlight its unmet needs. METHODS: A physician-based anonymous international e-survey supported by several European Nephrology Networks/Societies was conducted...
November 28, 2022: Nephrology, Dialysis, Transplantation
#4
JOURNAL ARTICLE
Simon Oehm, Konstantin Steinke, Johannes Schmidt, Sita Arjune, Polina Todorova, Christoph Lindemann, Fabian Wöstmann, Franziska Meyer, Florian Siedek, Thomas Weimbs, Roman-Ulrich Müller, Franziska Grundmann
BACKGROUND: Ketogenic dietary interventions (KDI) have been shown to be effective in animal models of polycystic kidney disease, but data from clinical trials are lacking. METHODS: Ten ADPKD patients with rapid disease progression were enrolled at visit V1 and initially maintained a carbohydrate (CHO)-rich diet. At V2, patients entered one of the two KDI arms: a 3-day water fast (WF) or a 14-day ketogenic diet (KD). At V3, they resumed their normal diet for 3 to 6 weeks until V4...
November 24, 2022: Nephrology, Dialysis, Transplantation
#5
JOURNAL ARTICLE
Borja Quiroga, María José Soler, Alberto Ortiz, Carlos Jesús Jarava Mantecón, Virginia Olinda Gomes Pérez, Antoni Bordils, José Lacueva, Antonio José Marin Franco, Pablo Delgado Conde, Patricia Muñoz Ramos, Carmen Calderón González, Juan Manuel Cazorla López, Jinny Sanchez-Rodriguez, Ana Sánchez Horrillo, Tania Raquel Monzón Vázquez, Alba Leyva, José Rojas, Ron T Gansevoort, Patricia de Sequera, María Teresa Jaldo Rodríguez, Rafael Lucena Valverde, Marta Puerta Carretero, Mayra Ortega Díaz, Daniel Gaitán Tocora, Esther Rodriguez Suárez, Alfredo José Sáenz Santolaya, Patricia Arribas Cobo, Tamar Talavan, Raquel Cerrajero Calero, Carolina Gracia-Iguacel, Emilio González-Parra, Mónica Pereira, Catalina Martin-Cleary, Ana Ramos-Verde, Martín Giorgi, Carmen Sánchez, Yohana Gil Giraldo, Ana Sánchez Horrillo, Pablo Ruano Suárez, Antonio Fernández Perpén, Andrés Fernández Ramos, Laura Salanova Villanueva, Alejandra Cortiñas, Pablo A Díez Arias, Alicia Cabrera Cárdenas, Antonio de Santos, Almudena Núñez, Guillermina Barril Cuadrado, Loreto Mariscal de Gante, Raquel Repollet, Concepción Redondo Polo, Francesc Moreso, María Antonieta Azancot, Natalia Ramos, Oriol Bestard Nestor Toapanta, Ignacio Cidraque, Sheila Bermejo, Irene Agraz, Oreto Prat, Carlota Medina, Emma Pardo, Oreto Prat, Alejandro Saiz, Maria Antònia Munar Vila, Secundino Cigarrán Guldris, Nicolás Menéndez Granados, María Jesús Corton Cabo, Walter López Alarcón, Soledad Pizarro Sánchez, Simona Alexandru, Laura García Puente Suarez, Saul Pampa Saico, Marisol Poma Tapia, Rocío Zamora, Rosa Sánchez Hernández, Laura Rodríguez Osorio, Nuria García-Fernández, Paloma Leticia Martin Moreno, Noelia Ania González, Ana Sabalza Ortiz, María Nieves Bastida Iñarrea, Sagrario Soriano Cabrera, Raquel Ojeda López, Cayetana Moyano Peregrí, Maria Luisa Agüera Morales, Maria Dolores Navarro Cabello, Auxiliadora Mazuecos, Teresa García, Carlos Narváez, Cristhian Orellana, María Gabriela Sánchez Márquez, Carolina Lancho Novillo, Pedro Luis Quirós Ganga, Fernando Vallejo Carrión, Antonio Luis García Herrera, Natalia Blanco Castro, Rosa María Ruiz-Calero Cendrero, María Victoria Martín Hidalgo-Barquero, Román Hernández Gallego, Álvaro Alvarez, Eva Vázquez Leo, José Luis Pizarro León, Manuel Antonio Martínez García, Benaldina García Jiménez, Virginia Olinda Gómez Pérez, Juan de Dios Ramiro Moya, Diana López Espinosa, Alejandro Jiménez Herrador, Manuel Navarro Zurita, Leonardo Díaz Álvarez, Álvaro González Martínez, Sandra Báez Arroyo, Raquel Reina Fernández, Marlyn Janella Suárez Vargas, Rocío Calurano Casero, Gustavo Useche, Amparo Bernat García, Ana Beatriz Muñoz Díaz, Carmen Santamaría de Miguel, Ángel Palacios, Brenda Henningsmeyer, Esther Orero Calve, José Lacueva Moya, Yurika Sato, Marta Serra Marín, Sandra Tejedor, Shaida Martínez Vaquera, Manuel Carnerero di Riso, Irene Torres, Georgina Alfaro, Olga Halauko, Fouad E L Rifai, Ana Dolores Martínez, Pablo Justo Ávila, Christian Alfaro Sánchez, Marta Sanz Sainz, José María Baltar Martín, Laura Del Río García, José Luis Pérez Canga, Paola Milena Villabón Ochoa, Laura Muñiz Pacios, Lina León Machado, Augusto Quiroz Morales, Ignacio Manzur Cavalotti, Itziar Navarro Zorita, Sol Otero López, Sara Outon González, Carlos Soto Montañez, Auxiliadora Bajo Rubio, Gloria Del Peso Gilsanz, Marta Ossorio Gonzalez, Rafael Sánchez Villanueva, Maria Ovidia Lopez Oliva, Jesús Calviño Varela, Alba García Enríquez, Carmen Cobelo Casas, Pablo Otero Alonso, Lourdes González Tabares, José María Lamas Barreiro, Luisa Palomares Solla, Arginino Gándara, Walfred Nájera de la Garza, Francisco Fernández Fleming, María Gloria Rodríguez Goyanes, Cintia Caramés Feijoo, María Mercedes Moreiras Plaza, Cristina Bayón Juan, Gabriel de Arriba de la Fuente, Katia Pérez Del Valle, Francisco Javier Pérez Contreras, Noelia Balibrea Lara, Dioné González Ferri, Eduardo Muñoz de Bustillo Llorente, Enriqueta González Rodríguez, Virginia Lopez De La Manzanara Perez, Marta Calvo Arevalo, Jose Antonio Herrero Calvo, María Rosario Llópez Carratalá, Leyre María Martin Rodríguez, Marisa Serrano Salazar, Begoña Bravo Prieto, José María Portolés Pérez, Antonio Gil Paraíso, Emma Huarte, M Lanau, Rodrigo Avellaneda Campos, José Manuel Ubé, Isabel Berdud Godoy, Esther Torres Aguilera, Rolando Tello Alea, Margie Soledad Del Rosario Saldaña, Mercedes Salgueira, Nuria Aresté, María de Los Ángeles Rodríguez, Rocío Collantes, Ana Isabel Martínez, María Jesús Moyano, Elena Jiménez Víbora, Sandra Castellano Gash, Lara Ruíz Martínez, María Cinta Aguilar Cervera, María Teresa Rodrigo De Tomas, Beatriz Azcue Prieto, Carmen Toyos, José Molina Del Rio, Adriana Restrepo Acosta, Amagoia Celayeta Zamacona, Ma Isabel Jimeno Martin, Saioa Bilbao Ortega, Ma Isabel Gallardo Ruiz, Ainhoa Hernando Rubio, Paula Garcia Ledesma, Alvaro Goyoaga Alvarez, Esteban Poch, David Cucchiari, José Broseta Monzo, Beatriz Escamilla Cabrera, Aurelio Pastor Rodríguez Hernández, María Sagrario García Rebollo, Juana Margarita Rufino Hernández, Alejandra Yugueros González, Juan Carlos Alonso, Amparo Martínez Más, Manuel Calvé, Marina Garces Cardona, Vanesa Canto Balaguer, José Ignacio Minguela Pesquera, Eva Cotilla de la Rosa, David Rodríguez Santarelli, Alba Santos Garcia, Antonio Cabezas Martin-Caro, Inmaculada Martinez Santamaria, Michal Cervienka, Ana María Urraca de la Pisa, Lidia Sendino Monzon, Karina Ampuero Anachuri, Esther Hernández Garcia, Victoria Oviedo Gomez, Raquel Santana Estupiñán, Francisco Valga Amado, Patricia Pérez Borges, Marta Durán Beloso, Fernanda Arroyo Alonso, Noemí Pérez Felpete, Ana Meizoso Ameneiro, Mónica Cunha Mera, Beatriz Gil Casares, Sofía Zarraga Larrondo, Naroa Maruki Kareaga, Ainhoa Inza San Salvador Del Valle, Ana Rosa Muñoz García, Blanca Villacorta Linaza, Nuria Del Toro Espinosa, Paola Estupiñan Perico, José Manuel Sánchez Oliva, Joaquín Manrique, Itziar Castaño, Carolina Purroi, Nerea Gómez, Cristina Mansilla, Ane Utzurrum, Manuel Ramírez de Arellano Serna, Luis Guirado Perich, María Muñiz Rincón, Virginia Lopez De La Manzanara Perez, Marta Calvo Arevalo, Jose Antonio Herrero Calvo, Jesús Grande Villoria, Alfonso Pobes Martínez De Salinas
BACKGROUND: There is scarce evidence on fourth doses of SARS-CoV-2 vaccines in chronic kidney disease (CKD) patients. We have evaluated the humoral response and effectivity of the fourth dose in the CKD spectrum: non-dialysis CKD (ND-CKD), hemodialysis (HD), peritoneal dialysis (PD) and kidney transplant (KT) recipients. METHODS: This is a prespecified analysis of the prospective, observational, multicentric SENCOVAC study. In patients with CKD who had received a complete initial vaccination and one or two boosters and had anti-Spike antibody determinations 6 and 12 months after the initial vaccination, we analyzed factors associated to persistent negative humoral response and to higher anti-Spike antibody titers as well as the efficacy of vaccination on COVID-19 severity...
November 24, 2022: Nephrology, Dialysis, Transplantation
#6
JOURNAL ARTICLE
Huan Yang, Yong Wu, Ming Cheng, Ming Zhang, Xiaoyan Qiu, Shaojun Liu, Minmin Zhang
BACKGROUND: The hypoxia mediated inflammation plays crucial role in renal ischemia reperfusion (I/R) induced acute kidney injury (AKI) and may influence renal graft survival, with no available pharmacological treatments. Here we investigate the protective effects and mechanism of Roxadustat (FG-4592), a HIF stabilizer, against renal IRI. METHODS: The protein expression levels of CD73 and AIM2 inflammasome complex were examined in kidney biopsy specimens of AKI and post-renal transplantation (PRT) patients...
November 22, 2022: Nephrology, Dialysis, Transplantation
#7
JOURNAL ARTICLE
Priya Vart, Raphaël Duivenvoorden, Casper F M Franssen, Marc H Hemmelder, Kitty J Jager, Luuk B Hilbrands, Marlies Noordzij, Daniel Abramowicz, Carlo Basile, Adrian Covic, Marta Crespo, Ziad A Massy, Alberto Ortiz, J Emilio Sanchez, Emily Petridou, Colin White, Ron T Gansevoort
Owing to the vulnerability of patients with chronic kidney disease to infectious diseases, the coronavirus disease 2019 (COVID-19) pandemic has been particularly devastating for the nephrology community. Unfortunately, the possibility of future COVID-19 waves or outbreaks of other infectious diseases with pandemic potential cannot be ruled out. The nephrology community made tremendous efforts to contain the consequences of the COVID-19 pandemic. Despite this, the COVID-19 pandemic has highlighted several shortcomings in our response to the pandemic and has taught us important lessons that can be utilized to improve our preparedness for any future health crises of similar nature...
November 16, 2022: Nephrology, Dialysis, Transplantation
#8
JOURNAL ARTICLE
Maxime Teisseyre, Daisy Graça, Daniel Re, Marion Cremoni, Sylvia Benzaken, Kévin Zorzi, Céline Fernandez, Vincent L M Esnault, Jérôme Barrière, Vesna Brglez, Barbara Seitz-Polski
No abstract text is available yet for this article.
November 9, 2022: Nephrology, Dialysis, Transplantation
#9
JOURNAL ARTICLE
Vandana S Mathur, David A Bushinsky, Lesley Inker, Gerrit Klaerner, Elizabeth Li, Dawn Parsell, Vlado Perkovic, Yuri Stasiv, Michael Walker, Donald E Wesson, David C Wheeler, Navdeep Tangri
BACKGROUND: Whether treating metabolic acidosis slows progression of chronic kidney disease (CKD) has not been established. Veverimer is a novel hydrochloric acid binder that removes acid from the gastrointestinal tract leading to an increase in serum bicarbonate; it is being developed to treat metabolic acidosis with the goal of slowing progression of CKD. METHODS: The VALOR-CKD trial is an international, randomized, multicenter, double-blind, placebo-controlled study designed to evaluate the effect of once-daily veverimer on kidney disease progression in patients with metabolic acidosis and CKD...
November 4, 2022: Nephrology, Dialysis, Transplantation
#10
JOURNAL ARTICLE
Esteban Porrini, Nuria Montero Pérez, Juan Manuel Díaz, Ricardo Lauzurrica, Juana Oramas Rodríguez, Irene Silva Torres, Francesc Moreso, Josep M Cruzado Garrit, Rocío Benítez Ruiz, Meritxel Ibernon Vilaró, Maria Xixiang Molina Lima, Simran Khemlani Ramchand, Juan Carlos Ruiz, Francisco Gainza de Los Rios, Carla Rodríguez Alvarez, María Del Carmen de Gracia Guindo, Manuel Macías, David Bonet Vela, Antonio Osuna, Beatriz Bayés-Genís, Cristina Aleman Sanchez, María Del Carmen Ruiz, Ana Elena Rodríguez Rodríguez, Rosa Domínguez Rollán, Federico González Rinne, Alejandro Jiménez Sosa, Patricia Delgado Mallén, Ana González Rinne, Domingo Marrero Miranda, Armando Torres
BACKGROUND: Diabetes is a risk factor for cancer in the general population. However, few data is available on the association between post-transplant diabetes mellitus (PTDM) and cancer after transplantation. METHODS: We analyzed this issue in a Spanish cohort of patients without diabetes before transplantation. PTDM was diagnosed with consensus criteria at 12 months after transplantation and 12 months before the diagnosis of cancer. The association between PTDM and cancer (overall and specific types) was evaluated with regression analysis...
November 2, 2022: Nephrology, Dialysis, Transplantation
#11
JOURNAL ARTICLE
Robin Greinert, Daniel Greinert, Anna-Lena Eger, Cristina Ripoll, Matthias Girndt
BACKGROUND: Cognitive impairment (CI) in chronic kidney disease (CKD) is highly prevalent and is associated with multiple limitations to the patients who show a higher mortality, more days of hospitalisation and a lower quality of life. Frailty in CKD is associated with adverse health outcomes and is also highly prevalent. The aim of our study was to determine the prevalence and characteristics of CI and relate the findings to frailty, mobility, muscle strength, and Health-Related Quality of Life (HRQoL)...
November 2, 2022: Nephrology, Dialysis, Transplantation
#12
JOURNAL ARTICLE
Reid H Whitlock, Thomas W Ferguson, Paul Komenda, Claudio Rigatto, David Collister, Clara Bohm, Nancy L Reaven, Susan E Funk, Navdeep Tangri
BACKGROUND: Guidelines recommend treatment of metabolic acidosis (MA) in patients with chronic kidney disease (CKD), but diagnosis and treatment rates in real-world settings are unknown. We investigated the frequency of MA treatment and diagnosis in patients with CKD. METHODS: In this retrospective cohort study, we examined administrative health data from 2 US databases (Optum's de-identified Integrated Claims + Clinical Electronic Health Record Database (US EMR cohort; January 1, 2007 to June 30, 2019) and Symphony Health Solutions IDV® (US Claims cohort; May 1, 2016 to April 30, 2019)) and population-level databases from Manitoba, Canada (April 1, 2006 to March 31, 2018)...
November 2, 2022: Nephrology, Dialysis, Transplantation
#13
JOURNAL ARTICLE
Abril A Perez-Arias, Sofía Márquez-Macedo, Oscar R Pena-Vizcarra, María Fernanda Zavala-Miranda, Juanita Romero-Díaz, Luis E Morales-Buenrostro, Juan M Mejía-Vilet
BACKGROUND: Repeated renal flares in lupus nephritis (LN) have been associated with worse long-term kidney function. This study aimed to assess the impact of repeated LN flares in response to therapy, kidney, and patient prognosis. METHODS: All patients from a biopsy-proven LN cohort between 2 008 and 2 018 were segregated into three groups according to the number of LN flares when they entered our cohort: first LN flare, second LN flare, or third LN flare. The following outcomes were evaluated by unadjusted and adjusted time-to-event analyses: complete and partial response, disease relapses, progression to decline of 30% of the eGFR, doubling of serum creatinine, end-stage kidney disease, and patient survival...
November 1, 2022: Nephrology, Dialysis, Transplantation
#14
JOURNAL ARTICLE
Jennifer S Lees, Stephen J H Dobbin, Benjamin M P Elyan, David F Gilmour, Laurie P Tomlinson, Ninian N Lang, Patrick B Mark
BACKGROUND: Vascular endothelial growth factor inhibitors (VEGFi) have transformed the treatment of many retinal diseases, including diabetic maculopathy. Increasing evidence supports systemic absorption of intravitreal VEGFi and development of significant cardiorenal side effects. METHODS: Systematic review and meta-analysis (PROSPERO: CRD42020189037) of randomised controlled trials of intravitreal VEGFi treatments (bevacizumab, ranibizumab and aflibercept) for any eye disease...
November 1, 2022: Nephrology, Dialysis, Transplantation
#15
JOURNAL ARTICLE
Rianne Schutter, Willemijn A L Vrijlandt, Gelske M Weima, Robert A Pol, Jan-Stephan F Sanders, Meindert J Crop, Henri G D Leuvenink, Cyril Moers
BACKGROUND: To ensure optimal utilization of deceased donor kidneys, it is important to understand the precise reasons why kidneys are discarded. In this study, we aimed to obtain a comprehensive overview of kidney utilization and discard during the entire donation process in the Netherlands. METHODS: In this retrospective cohort study we analyzed kidney utilization of 3856 kidneys in the Netherlands between 1 January 2015 and 31 December 2020. For every kidney that was not transplanted, we determined the moment of and reason for discard through a unique case-by-case assessment...
November 1, 2022: Nephrology, Dialysis, Transplantation
#16
JOURNAL ARTICLE
Gregory L Hundemer, Pietro Ravani, Manish M Sood, Deborah Zimmerman, Amber O Molnar, Danielle Moorman, Matthew J Oliver, Christine White, Swapnil Hiremath, Ayub Akbari
BACKGROUND: The transition from CKD to kidney failure is a vulnerable time for patients, with suboptimal transitions associated with increased morbidity and mortality. Whether social determinants of health are associated with suboptimal transitions is not well understood. METHODS: This retrospective cohort study included 1,070 patients with advanced CKD who were referred to the Ottawa Hospital Multi-Care Kidney Clinic and developed kidney failure (dialysis or kidney transplantation) between 2010-2021...
October 31, 2022: Nephrology, Dialysis, Transplantation
#17
JOURNAL ARTICLE
Geoffrey Van den Bergh, Britt Opdebeeck, Cédric Neutel, Pieter-Jan Guns, Guido De Meyer, Patrick D'Haese, Anja Verhulst
BACKGROUND: Cardiovascular disease remains the leading cause of death in chronic kidney disease (CKD) patients, especially in those undergoing dialysis and kidney transplant surgery. CKD patients are at high risk to develop arterial media calcifications (AMC) and arterial stiffness. We hypothesized that investigation of disease progression at an early stage could provide novel insights in understanding AMC etiology. METHODS: An adenine diet was administered to male Wistar rats to induce AMC...
October 31, 2022: Nephrology, Dialysis, Transplantation
#18
JOURNAL ARTICLE
Junichi Hoshino, Masanori Abe, Takayuki Hamano, Takeshi Hasegawa, Atsushi Wada, Shigeru Nakai, Norio Hanafusa, Ikuto Masakane, Kosaku Nitta
Hemoglobin A1c (A1c) and glycated albumin (GA) are two blood glycated proteins commonly used to monitor glycemic control in dialysis patients with diabetes. However, little is known about the association between the GA/A1c ratio and mortality in these populations. Here, we examine these associations using a nationwide cohort. We enrolled 28 994 dialysis patients with diabetes who met our inclusion criteria (female, 32.9%; mean age, 67.4 ± 11.6 years; mean dialysis duration, 6.3 ± 5.8 years). After dividing the patients into groups based on GA/A1c quantiles and adjusting for 18 potential confounders, adjusted hazard ratios and 95% confidence limits were calculated for 3-year mortality and cause-specific mortalities...
October 29, 2022: Nephrology, Dialysis, Transplantation
#19
JOURNAL ARTICLE
Matteo Bargagli, Andri Vetsch, Manuel A Anderegg, Nasser A Dhayat, Uyen Huynh-Do, Nicolas Faller, Bruno Vogt, Pietro Manuel Ferraro, Daniel G Fuster
BACKGROUND: Autosomal-dominant polycystic kidney disease (ADPKD) is characterized by a unique bone and mineral phenotype. The impact of Tolvaptan treatment on mineral metabolism and bone mineral density is unknown. METHODS: We conducted an analysis in the Bern ADPKD registry, a prospective observational cohort study. Mineral metabolism parameters were measured at baseline and every 12 months thereafter. Bone mineral density was determined by dual-energy X-ray absorptiometry at baseline and after 3 years...
October 29, 2022: Nephrology, Dialysis, Transplantation
#20
JOURNAL ARTICLE
Franco Wing Tak Cheng, Carlos King Ho Wong, Simon Xiwen Qin, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Eric Yuk Fai Wan, Esther W Chan, Chi Ho Au, Xuxiao Ye, Sydney Chi Wai Tang, Ian Chi Kei Wong
BACKGROUND: With accruing case reports on de novo or relapsing glomerular diseases (GD) following different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines, we evaluated the risk of GD following BNT162b2 and CoronaVac vaccines. METHODS: A modified self-controlled case series analysis was conducted using anonymized, territory-wide SARS-CoV-2 vaccination records in Hong Kong. All Hong Kong residents aged 18 years or above with outcomes of interest were included...
October 28, 2022: Nephrology, Dialysis, Transplantation
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