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Nephrology, Dialysis, Transplantation

Ailish Nimmo, Charu Chopra, Robert W Hunter
No abstract text is available yet for this article.
July 11, 2019: Nephrology, Dialysis, Transplantation
Wei Chen, Ruth Eisenberg, Wenzhu B Mowrey, Judith Wylie-Rosett, Matthew K Abramowitz, David A Bushinsky, Michal L Melamed
BACKGROUND: In animal studies, zinc supplementation inhibited phosphate-induced arterial calcification. We tested the hypothesis that higher intake of dietary zinc was associated with lower abdominal aortic calcification (AAC) among adults in the USA. We also explored the associations of AAC with supplemental zinc intake, total zinc intake and serum zinc level. METHODS: We performed cross-sectional analyses of 2535 participants from the National Health and Nutrition Examination Survey 2013-14...
July 11, 2019: Nephrology, Dialysis, Transplantation
Priscila Carmona, Yordanka Medina-Armenteros, Amanda Cabral, Sandra Maria Monteiro, Simone Gonçalves Fonseca, Ana Caetano Faria, Francine Lemos, David Saitovitch, Irene L Noronha, Jorge Kalil, Verônica Coelho
BACKGROUND: Antigen-specific cellular response is essential in immune tolerance. We tested whether antigen-specific cellular response is differentially modulated in operational tolerance (OT) in renal transplantation with respect to critical antigenic challenges in allotransplantation-donor antigens, pathogenic antigens and self-antigens. METHODS: We analysed the profile of immunoregulatory (REG) and pro-inflammatory (INFLAMMA) cytokines for the antigen-specific response directed to these three antigen groups, by Luminex...
July 5, 2019: Nephrology, Dialysis, Transplantation
Emilie Bres, Laetitia Koppe
No abstract text is available yet for this article.
July 5, 2019: Nephrology, Dialysis, Transplantation
Charlotte E Buchanan, Huda Mahmoud, Eleanor F Cox, Thomas McCulloch, Benjamin L Prestwich, Maarten W Taal, Nicholas M Selby, Susan T Francis
BACKGROUND: Multi-parametric magnetic resonance imaging (MRI) provides the potential for a more comprehensive non-invasive assessment of organ structure and function than individual MRI measures, but has not previously been comprehensively evaluated in chronic kidney disease (CKD). METHODS: We performed multi-parametric renal MRI in persons with CKD (n = 22, 61 ± 24 years) who had a renal biopsy and measured glomerular filtration rate (mGFR), and matched healthy volunteers (HV) (n = 22, 61 ± 25 years)...
June 29, 2019: Nephrology, Dialysis, Transplantation
Christine Barrett, Lisa C Willcocks, Rachel B Jones, Ruth M Tarzi, Robert B Henderson, Gengqian Cai, Sophie I Gisbert, Alexandra S Belson, Caroline O Savage
BACKGROUND: Immunosuppressant drugs reduce proteinuria and anti-phospholipase A2 receptor autoantibodies (PLA2R-Ab) in primary membranous nephropathy (PMN) with varying success and associated toxicities. This study aimed to evaluate the effect of belimumab on proteinuria and PLA2R-Ab in participants with PMN. METHODS: In this prospective, open-label, experimental medicine study, 14 participants with PMN and persistent nephrotic-range proteinuria received up to 2 years belimumab monotherapy (10 mg/kg, every 4 weeks)...
June 26, 2019: Nephrology, Dialysis, Transplantation
Cheng Xue, Yan-Yan Gu, Cheng-Ji Cui, Chen-Chen Zhou, Xian-Dong Wang, Meng-Na Ruan, Lin-Xi Huang, Si-Xiu Chen, Bo Yang, Xu-Jiao Chen, Yi-Xin Qian, Jun Wu, Xue-Zhi Zhao, Yu-Qiang Zhang, Chang-Lin Mei, Shou-Lin Zhang, Jing Xu, Zhi-Guo Mao
BACKGROUND: Peritoneal dialysis (PD) patients are at high risk of developing glucose metabolism disturbance (GMD). The incidence and prevalence of new-onset GMD, including diabetes mellitus (DM), impaired glucose tolerance (IGT) and impaired fast glucose (IFG), after initiation of PD, as well as their correlated influence factors, varies among studies in different areas and of different sample sizes. Also, the difference compared with hemodialysis (HD) remained unclear. Thus we designed this meta-analysis and systematic review to provide a full landscape of the occurrence of glucose disorders in PD patients...
June 24, 2019: Nephrology, Dialysis, Transplantation
Xavier Vela, Arvind Conjeevaram, Sonia Rodriguez, Tejas Desai
No abstract text is available yet for this article.
June 20, 2019: Nephrology, Dialysis, Transplantation
Lucile Figueres, Maryvonne Hourmant, Sandrine Lemoine
No abstract text is available yet for this article.
June 20, 2019: Nephrology, Dialysis, Transplantation
Miriam Zacchia, Emanuela Marchese, Elena Martina Trani, Marianna Caterino, Giovanna Capolongo, Alessandra Perna, Margherita Ruoppolo, Giovambattista Capasso
The primary cilium (PC) was considered as a vestigial organelle with no significant physiological importance, until the discovery that PC perturbation disturbs several signalling pathways and results in the dysfunction of a variety of organs. Genetic studies have demonstrated that mutations affecting PC proteins or its anchoring structure, the basal body, underlie a class of human disorders (known as ciliopathies) characterized by a constellation of clinical signs. Further investigations have demonstrated that the PC is involved in a broad range of biological processes, in both developing and mature tissues...
June 20, 2019: Nephrology, Dialysis, Transplantation
Charat Thongprayoon, Wisit Cheungpasitporn, John Q Yap, Qi Qian
BACKGROUND: This study aimed to evaluate short-term and long-term mortalities in a cohort of unselected hospitalized patients with serum sodium concentration ([Na+]) variations within and outside of reference range. METHODS: All adult patients admitted to the Mayo Clinic, Rochester, MN, USA from January 2011 to December 2013 (n = 147358) were retrospectively screened. Unique patients admitted during the study period were examined. The main exposure was serum [Na+] variation...
June 20, 2019: Nephrology, Dialysis, Transplantation
Guobin Su, Marco Trevisan, Junichi Ishigami, Kunihiro Matsushita, Cecilia Stålsby Lundborg, Juan Jesus Carrero
BACKGROUND: Little is known about the health sequelae of pneumonia in persons with chronic kidney disease (CKD). METHODS: We studied adults with CKD in Stockholm during 2006-11, who not previously been diagnosed with lower respiratory tract infections. We used multivariable-adjusted Cox regression with pneumonia as a time-varying exposure to estimate hazard ratios (HRs) [95% confidence intervals (CIs)] for the events of death, major adverse cardiovascular events (MACEs), acute kidney injury (AKI), CKD progression or hospitalization for urinary tract infections (UTIs)/sepsis...
June 20, 2019: Nephrology, Dialysis, Transplantation
Maleeka Ladhani, Jonathan C Craig, Germaine Wong
BACKGROUND: Despite the survival advantage of transplantation over dialysis, obese patients are less likely to be listed on the deceased donor waiting list and subsequently transplanted. This study aimed to determine the association between obesity and access to deceased donor transplantation and whether any association observed was applicable to men and women equally. METHODS: Cox proportional hazards models were conducted to determine the association between obesity and waitlisting for transplantation and then subsequent receipt of a kidney transplant using data from the Australian and New Zealand Dialysis and Transplant Registry (2007-14)...
June 15, 2019: Nephrology, Dialysis, Transplantation
Ziad A Massy, Fergus J Caskey, Patrik Finne, Jerome Harambat, Kitty J Jager, Evi Nagler, Benedicte Stengel, Mehmet Sukru Sever, Raymond Vanholder, Peter J Blankestijn, Annette Bruchfeld, Giovambattista Capasso, Danilo Fliser, Denis Fouque, Dimitrios Goumenos, Maria Jose Soler, Ivan Rychlík, Goce Spasovski, Katelyn Stevens, Christoph Wanner, Carmine Zoccali
The strengths and the limitations of research activities currently present in Europe are explored in order to outline how to proceed in the near future. Epidemiological and clinical research and public policy in Europe are generally considered to be comprehensive and successful, and the European Renal Association - European Dialysis and Transplant Association (ERA-EDTA) is playing a key role in the field of nephrology research. The Nephrology and Public Policy Committee (NPPC) aims to improve the current situation and translation into public policy by planning eight research topics to be supported in the coming 5 years by ERA-EDTA...
June 14, 2019: Nephrology, Dialysis, Transplantation
David Schmit, Danilo Fliser, Thimoteus Speer
Chronic kidney disease (CKD) is associated with a substantially increased risk for the development of atherosclerotic cardiovascular (CV) disease. Accordingly, CV mortality is increased even in the earliest stages of CKD. In the general population and in CKD patients, high plasma levels of low-density lipoprotein cholesterol (LDL-C) are crucially involved in the initiation and progression of atherosclerotic vascular lesions. Lowering LDL-C by use of statins and/or ezetimibe represents the gold standard of lipid-lowering therapy, with a great body of evidence from several large clinical trials...
June 13, 2019: Nephrology, Dialysis, Transplantation
Roser Torra, Mónica Furlano
Alport syndrome (AS) is the most frequent inherited kidney disease after autosomal dominant polycystic kidney disease. It has three different patterns of inheritance-autosomal dominant, autosomal recessive and X-linked-which in part explains the wide spectrum of disease, ranging from isolated microhaematuria to end-stage renal disease early in life. The search for a treatment for AS is being pursued vigorously, not only because of the obvious unmet need but also because AS is a rare disease and any drug approved will have an orphan drug designation with its various benefits...
June 13, 2019: Nephrology, Dialysis, Transplantation
Csaba P Kovesdy
Patients with end-stage renal disease (ESRD) experience extremely high morbidity and mortality and there are virtually no therapeutic interventions besides dialysis treatment that are proven in properly designed randomized controlled trials (RCTs) to improve patients' outcomes. Historically, the number of RCTs performed in the ESRD population has been very low compared with other medical subspecialties, and several of the few large RCTs have yielded inconclusive or negative results, dampening enthusiasm for future investment in similar trials...
June 13, 2019: Nephrology, Dialysis, Transplantation
Raymond Vanholder, Wim Van Biesen, Jonathan G Fox, Evi V Nagler
No abstract text is available yet for this article.
June 13, 2019: Nephrology, Dialysis, Transplantation
Marc G Vervloet
No abstract text is available yet for this article.
June 10, 2019: Nephrology, Dialysis, Transplantation
Jong Hyun Jhee, Youn Kyung Kee, Seohyun Park, Hyoungnae Kim, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Tae-Hyun Yoo
BACKGROUND: The effect of a high-protein diet with renal hyperfiltration (RHF) on decline of kidney function has rarely been explored. We investigated the association between a high-protein diet, RHF and declining kidney function. METHODS: A total of 9226 subjects from the Korean Genome and Epidemiology Study, a community-based prospective study (2001-14), were enrolled and classified into quartiles according to daily amount of protein intake based on food frequency questionnaires...
June 7, 2019: Nephrology, Dialysis, Transplantation
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