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Nephrology, Dialysis, Transplantation

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https://read.qxmd.com/read/31495893/munc18-1-interacting-protein-3-mitigates-renal-fibrosis-through-protection-of-tubular-epithelial-cells-from-apoptosis
#1
Kahori Nasu, Takahisa Kawakami, Akinari Shinohara, Takeharu Sakamoto, Masaomi Nangaku
BACKGROUND: Tubulointerstitial fibrosis is a hallmark of chronic kidney disease (CKD), and is initiated by tubular epithelial cell (TEC) injury. Hypoxia promotes tubular cell death, fibrosis and CKD progression. Munc18-1-interacting protein 3 (Mint3) is a molecule that activates hypoxia-inducible factors (HIFs) by binding and suppressing factor inhibiting HIF-1 (FIH). However, the role of Mint3 in tubulointerstitial fibrosis remains unknown. METHODS: We induced fibrosis of the kidney after unilateral ischemia-reperfusion injury (uIRI) in Mint3-knockout and littermate wild-type mice...
September 8, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31495887/the-association-of-beta-blocker-use-with-mortality-in-elderly-patients-with-congestive-heart-failure-and-advanced-chronic-kidney-disease
#2
Amber O Molnar, William Petrcich, Matthew A Weir, Amit X Garg, Michael Walsh, Manish M Sood
BACKGROUND: Whether the survival benefit of β-blockers in congestive heart failure (CHF) from randomized trials extends to patients with advanced chronic kidney disease (CKD) [estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m2 but not receiving dialysis] is uncertain. METHODS: This was a retrospective cohort study using administrative datasets. Older adults from Ontario, Canada, with incident CHF (median age 79 years) from April 2002 to March 2014 were included...
September 8, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31495881/choice-of-endpoint-in-kidney-outcome-trials-considerations-from-the-empa-reg-outcome%C3%A2-trial
#3
Vlado Perkovic, Audrey Koitka-Weber, Mark E Cooper, Guntram Schernthaner, Egon Pfarr, Hans J Woerle, Maximilian von Eynatten, Christoph Wanner
BACKGROUND: Doubling of serum creatinine [equivalent to 57% reduction in estimated glomerular filtration rate (eGFR)] is an established surrogate for end-stage kidney disease (ESKD); however, this endpoint necessitates lengthy follow-up and large sample sizes in clinical trials. We explored whether alternative eGFR decline thresholds provide more feasible surrogate kidney endpoints. METHODS: The study involved post hoc analysis of the EMPA-REG OUTCOME® trial. Adults with type 2 diabetes, high cardiovascular risk and eGFR ≥30 mL/min/1...
September 8, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31504790/dietary-vitamin-d-interacts-with-high-phosphate-induced-cardiac-remodeling-in-rats-with-normal-renal-function
#4
Ming Chang Hu, Roberto Scanni, Jianfeng Ye, Jianning Zhang, Mingjun Shi, Jenny Maique, Brianna Flores, Orson W Moe, Reto Krapf
BACKGROUND: Vitamin D (VD) and phosphate (Pi) load are considered as contributors to cardiovascular disease in chronic kidney disease and the general population, but interactive effects of VD and Pi intake on the heart are not clearly illustrated. METHODS: We fed normal male rats with three levels of dietary VD (100, 1100 or 5000 IU/kg chow) and Pi (0.2, 0.6 or 1.6%) (3X3 design) for 8 weeks and examined renal and cardiac function and histology. RESULTS: High dietary Pi decreased plasma and renal Klotho and plasma 25-hydroxyvitamin D, and increased plasma Pi, fibroblast growth factor 23 and parathyroid hormone without affecting renal function, while low Pi increased plasma and renal Klotho...
August 31, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31504813/is-high-volume-post-dilution-haemodiafiltration-associated-with-risk-of-fluid-volume-imbalance-a-national-multicentre-cross-sectional-cohort-study
#5
Charles Chazot, Sebastien Deleuze, Baya Fadel, Hadia Hebibi, Guillaume Jean, Martial Levannier, Olivier Puyoo, David Attaf, Stefano Stuard, Bernard Canaud
BACKGROUND: Fluid overload is frequent among hemodialysis (HD) patients. Dialysis therapy itself may favor sodium imbalance from sodium dialysate prescription. As on-line hemodiafiltration (OL-HDF) requires large amounts of dialysate infusion, this technique can expose to fluid accumulation in case of a positive sodium gradient between dialysate and plasma. To evaluate this risk, we have analyzed and compared the fluid status of patients treated with HD or OL-HDF in French NephroCare centers...
August 29, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31504777/loss-of-nlrp6-expression-increases-the-severity-of-acute-kidney-injury
#6
Lara Valiño-Rivas, Leticia Cuarental, Gabriel Nuñez, Ana B Sanz, Alberto Ortiz, Maria Dolores Sanchez-Niño
BACKGROUND: Nlrp6 is a nucleotide-binding oligomerization domain-like receptor (NLR) that forms atypical inflammasomes. Nlrp6 modulates the gut epithelium interaction with the microbiota. However, the expression and function of Nlrp6 in the kidney, a sterile environment, have not been characterized. We explored the role of Nlrp6 in acute kidney injury (AKI). METHODS: In a transcriptomics array of murine nephrotoxic AKI, Nlrp6 and Naip3 were the only significantly downregulated NLR genes...
August 29, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31436826/erratum
#7
Sofia Skampardoni, Dimitrios Poulikakos, Marek Malik, Darren Green, Philip A Kalra
No abstract text is available yet for this article.
August 22, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31436795/loss-of-sodium-chloride-co-transporter-impairs-the-outgrowth-of-the-renal-distal-convoluted-tubule-during-renal-development
#8
Christina Schnoz, Monique Carrel, Johannes Loffing
BACKGROUND: Loss-of-function mutations in the sodium chloride (NaCl) co-transporter (NCC) of the renal distal convoluted tubule (DCT) cause Gitelman syndrome with hypokalemic alkalosis, hypomagnesemia and hypocalciuria. Since Gitelman patients are usually diagnosed around adolescence, we tested the idea that a progressive regression of the DCT explains the late clinical onset of the syndrome. METHODS: NCC wild-type and knockout (ko) mice were studied at Days 1, 4 and 10 and 6 weeks after birth using blood plasma analysis and morphological and biochemical methods...
August 22, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31435654/dietary-satisfaction-and-quality-of-life-in-chronic-kidney-disease-patients-on-low-protein-diets-a-multicentre-study-with-long-term-outcome-data-torino-pisa-study
#9
Giorgina Barbara Piccoli, Biagio Raffaele Di Iorio, Antoine Chatrenet, Claudia D'Alessandro, Marta Nazha, Irene Capizzi, Federica Neve Vigotti, Antioco Fois, Stefania Maxia, Patrick Saulnier, Gianfranca Cabiddu, Adamasco Cupisti
BACKGROUND: Concerns about adherence and quality of life (QoL) limit the diffusion of low-protein diets (LPDs) as a way to slow chronic kidney disease (CKD) progression and postpone dialysis. The aim of this multicentre study is to assess dietary satisfaction in stable CKD patients. METHODS: This was a multicentre cross-sectional study with long-term follow-up data. Prevalent patients on LPD for at least 6 months were selected in four Italian centres. QoL was assessed using the World Health Organization Quality of Life questionnaire, and diet satisfaction with the Modification of Diet in Renal Disease satisfaction questionnaire...
August 21, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31411724/kidney-transplant-outcomes-in-recipients-with-visual-hearing-physical-and-walking-impairments-a-prospective-cohort-study
#10
Alvin G Thomas, Jessica M Ruck, Nadia M Chu, Dayawa Agoons, Ashton A Shaffer, Christine E Haugen, Bonnielin Swenor, Silas P Norman, Jacqueline Garonzik-Wang, Dorry L Segev, Mara McAdams-DeMarco
Disability in general has been associated with poor outcomes in kidney transplant (KT) recipients. However, disability can be derived from various components, specifically visual, hearing, physical and walking impairments. Different impairments may compromise the patient through different mechanisms and might impact different aspects of KT outcomes. Methods. In our prospective cohort study (June 2013-June 2017), 465 recipients reported hearing, visual, physical and walking impairments before KT. We used hybrid registry-augmented Cox regression, adjusting for confounders using the US KT population (Scientific Registry of Transplant Recipients, N = 66 891), to assess the independent association between impairments and post-KT outcomes [death-censored graft failure (DCGF) and mortality]...
August 14, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31411705/the-guanylate-cyclase-c-agonist-linaclotide-ameliorates-the-gut-cardio-renal-axis-in-an-adenine-induced-mouse-model-of-chronic-kidney-disease
#11
Fumika Nanto-Hara, Yoshitomi Kanemitsu, Shinji Fukuda, Koichi Kikuchi, Kei Asaji, Daisuke Saigusa, Tomoyuki Iwasaki, Hsin-Jung Ho, Eikan Mishima, Takehiro Suzuki, Chitose Suzuki, Tomoya Tsukimi, Tetsuro Matsuhashi, Yoshitsugu Oikawa, Yukako Akiyama, Shigeo Kure, Yuji Owada, Yoshihisa Tomioka, Tomoyoshi Soga, Sadayoshi Ito, Takaaki Abe
BACKGROUND: Cardiorenal syndrome is a major cause of mortality in patients with chronic kidney disease (CKD). However, the involvement of detrimental humoral mediators in the pathogenesis of cardiorenal syndrome is still controversial. Trimethylamine-N-oxide (TMAO), a hepatic metabolic product of trimethylamine generated from dietary phosphatidylcholine or carnitine derived by the gut microbiota, has been linked directly with progression of cardiovascular disease and renal dysfunction...
August 14, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31411695/outcome-of-children-with-shiga-toxin-associated-haemolytic-uraemic-syndrome-treated-with-eculizumab-a-matched-cohort-study
#12
Catherine Monet-Didailler, Audrey Chevallier, Astrid Godron-Dubrasquet, Lise Allard, Yahsou Delmas, Cécile Contin-Bordes, Olivier Brissaud, Brigitte Llanas, Jérôme Harambat
BACKGROUND: Treatment with eculizumab in Shiga toxin-associated haemolytic and uraemic syndrome (STEC-HUS) remains controversial despite its increasing utilization. The aim of our study was to evaluate the outcomes of children treated with eculizumab for STEC-HUS in a single-centre matched cohort study. METHODS: Data were retrospectively collected from medical records of children diagnosed with STEC-HUS. The outcomes of patients treated with eculizumab for STEC-HUS were compared with those of a control group of untreated patients matched for age, sex and severity of acute kidney injury with a 1:2 matching scheme...
August 14, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31407789/renal-injury-and-human-immunodeficiency-virus-what-remains-after-30-years
#13
Sophie de Seigneux, Gregory M Lucas
No abstract text is available yet for this article.
August 13, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31407783/paving-the-way-towards-gender-equality-how-are-we-faring-in-nephrology
#14
Kate I Stevens, Maria J Soler, Annette Bruchfeld, Francesca Mallamaci
No abstract text is available yet for this article.
August 9, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31397483/haemodialysis-withdrawal-in-australia-and-new-zealand-a-binational-registry-study
#15
Samuel Chan, Mark R Marshall, Robert J Ellis, Dwarakanathan Ranganathan, Carmel M Hawley, David W Johnson, Martin J Wolley
BACKGROUND: Withdrawal from dialysis is an increasingly common cause of death in patients with end-stage kidney disease (ESKD). As most published reports of dialysis withdrawal have been outside the Oceania region, the aims of this study were to determine the frequency, temporal pattern and predictors of dialysis withdrawal in Australian and New Zealand patients receiving chronic haemodialysis. METHODS: This study included all people with ESKD in Australia and New Zealand who commenced chronic haemodialysis between 1 January 1997 and 31 December 2016, using data from the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry...
August 9, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31397476/erratum-to-sglt-2-inhibitors-and-glp-1-receptor-agonists-for-nephroprotection-and-cardioprotection-in-patients-with-diabetes-mellitus-and-chronic-kidney-disease-a-consensus-statement-by-the-eureca-m-and-the-diabesity-working-groups-of-the-era-edta
#16
Pantelis Sarafidis, Charles J Ferro, Enrique Morales, Alberto Ortiz, Jolanta Malyszko, Radovan Hojs, Khaled Khazim, Robert Ekart, Jose Valdivielso, Denis Fouque, Gérard M London, Ziad Massy, Petro Ruggenenti, Esteban Porrini, Andrzej Wiecek, Carmine Zoccali, Francesca Mallamaci, Mads Hornum
No abstract text is available yet for this article.
August 9, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31377791/initiation-of-sodium-polystyrene-sulphonate-and-the-risk-of-gastrointestinal-adverse-events-in-advanced-chronic-kidney-disease-a-nationwide-study
#17
Paola Laureati, Yang Xu, Marco Trevisan, Lovisa Schalin, Illaria Mariani, Rino Bellocco, Manish M Sood, Peter Barany, Arvid Sjölander, Marie Evans, Juan J Carrero
BACKGROUND: Despite long-standing clinical use of sodium polystyrene sulphonate (SPS) for hyperkalaemia management in chronic kidney disease (CKD), its safety profile remains poorly investigated. METHODS: We undertook an observational analysis of nephrology-referred adults with incident CKD Stage 4+ in Sweden during 2006-16 and with no previous SPS use. We studied patterns of use and adverse events associated to SPS initiation during follow-up. Patterns of SPS use were defined by chronicity of treatment and by prescribed dose...
August 4, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31377779/membranous-glomerulonephritis-a-step-forward-in-b-cell-targeting-therapy
#18
Karine Dahan, Jean-Jacques Boffa
No abstract text is available yet for this article.
August 4, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31377770/how-long-should-patients-be-observed-after-percutaneous-kidney-biopsies
#19
Julian Gary Abuelo
No abstract text is available yet for this article.
August 4, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/31377810/recurrent-acute-kidney-injury-predictors-and-impact-in-a-large-population-based-cohort
#20
Jennifer Holmes, John Geen, John D Williams, Aled O Phillips
BACKGROUND: This study examined the impact of recurrent episodes of acute kidney injury (AKI) on patient outcomes. METHODS: The Welsh National electronic AKI reporting system was used to identify all cases of AKI in patients ≥18 years of age between April 2015 and September 2018. Patients were grouped according to the number of AKI episodes they experienced with each patient's first episode described as their index episode. We compared the demography and patient outcomes of those patients with a single AKI episode with those patients with multiple AKI episodes...
August 3, 2019: Nephrology, Dialysis, Transplantation
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