Journals Nephrology, Dialysis, Transpla...

Nephrology, Dialysis, Transplantation
Rémi Kaboré, Loïc Ferrer, Cécile Couchoud, Julien Hogan, Pierre Cochat, Laurène Dehoux, Gwenaelle Roussey-Kesler, Robert Novo, Florentine Garaix, Karine Brochard, Marc Fila, Cyrielle Parmentier, Marie-Cécile Fournier, Marie-Alice Macher, Jérôme Harambat, Karen Leffondré
BACKGROUND: Several models have been proposed to predict kidney graft failure in adult recipients but none in younger recipients. Our objective was to propose a dynamic prediction model for graft failure in young kidney transplant recipients. METHODS: We included 793 kidney transplant recipients waitlisted before the age of 18 years who received a first kidney transplantation before the age of 21 years in France in 2002-13 and survived >90 days with a functioning graft...
September 29, 2020: Nephrology, Dialysis, Transplantation
Atul Anand, Tariq E Farrah, Eve Miller-Hodges, Anoop S V Shah, Fiona E Strachan, Edwin Carter, Neil R Johnston, David J Webb, Nicholas L Mills, Neeraj Dhaun
No abstract text is available yet for this article.
September 27, 2020: Nephrology, Dialysis, Transplantation
Michel Burnier
No abstract text is available yet for this article.
September 27, 2020: Nephrology, Dialysis, Transplantation
Stanislas Bataille, Philippe Chauveau, Denis Fouque, Michel Aparicio, Laetitia Koppe
Chronic kidney disease (CKD) patients often exhibit a low muscle mass and strength, leading to physical impairment and an increased mortality. Two major signalling pathways control protein synthesis, the insulin-like growth factor-1/Akt (IGF-1/Akt) pathway, acting as a positive regulator, and the myostatin (Mstn) pathway, acting as a negative regulator. Mstn, also known as the growth development factor-8 (GDF-8), is a member of the transforming growth factor-β superfamily, which is secreted by mature muscle cells...
September 24, 2020: Nephrology, Dialysis, Transplantation
Lilian Monteiro P Palma, Sanjeev Sethi
No abstract text is available yet for this article.
September 23, 2020: Nephrology, Dialysis, Transplantation
Claire Stein, Stéphane Burtey, Julien Mancini, Marion Pelletier, Marion Sallée, Philippe Brunet, Philippe Berbis, Jean Jacques Grob, Stéphane Honoré, Caroline Gaudy, Noémie Jourde-Chiche
BACKGROUND: Immune checkpoints inhibitors have transformed the prognosis of advanced melanoma but are associated with immune-related adverse events (irAEs). We evaluated the incidence, risk factors and causes of acute kidney injury (AKI) in a monocentric real-life cohort of patients treated with anti-programmed death receptor-1 (anti-PD1) antibodies for advanced melanoma. METHODS: Retrospective collection of medical charts and comprehensive analysis of lab results from patients treated with nivolumab or pembrolizumab for advanced melanoma between 2014 and 2018 was carried out...
September 17, 2020: Nephrology, Dialysis, Transplantation
Olivia Boyer, Guillaume Dorval, Aude Servais
No abstract text is available yet for this article.
September 17, 2020: Nephrology, Dialysis, Transplantation
Giuseppe Cianciolo, Gaetano La Manna, Irene Capelli, Lorenzo Gasperoni, Andrea Galassi, Paola Ciceri, Mario Cozzolino
Chronic kidney disease-mineral bone disorder (CKD-MBD) plays a pivotal role in the excess of cardiovascular morbidity and mortality associated with CKD. There is now a growing awareness that pathways involved in CKD-MBD, like canonical Wnt signalling, are activated from the earliest stages of CKD, playing a role in the development of adynamic bone disease with unknown consequences on vasculature. These changes occur before the classic changes in mineral metabolism: secondary hyperparathyroidism, calcitriol deficiency and hyperphosphataemia...
September 17, 2020: Nephrology, Dialysis, Transplantation
Emma Murphy, Aine Burns, Fliss E M Murtagh, Leila Rooshenas, Fergus J Caskey
Shared decision making in advanced chronic kidney disease (CKD) requires unbiased information on survival and person-centred outcomes known to matter to patients: quality of life, symptom burden and support from family and healthcare professionals. To date, when deciding between dialysis and conservative care, patients have had to rely on evidence from small observational studies. Clinicians recognize that like is not being compared with like in these studies, and interpret the results differently. Furthermore, support differs considerably between renal units...
September 17, 2020: Nephrology, Dialysis, Transplantation
Cihan Heybeli, Stephen B Erickson, Fernando C Fervenza, Marie C Hogan, Ladan Zand, Nelson Leung
BACKGROUND: Studies comparing all treatment options for frequently-relapsing/steroid-dependent (FR/SD) minimal change disease (MCD) in adults are lacking. METHODS: Medical records of 76 adults with FR/SD MCD who were treated with corticosteroids as the first-line therapy were reviewed. Treatment options were compared for the time to relapse, change of therapy and progression (relapse on full-dose treatment). RESULTS: Second-line treatments included rituximab (RTX; n = 13), mycophenolate mofetil (MMF; n = 12), calcineurin inhibitors (CNI; n = 26) and cyclophosphamide (CTX; n = 16)...
September 12, 2020: Nephrology, Dialysis, Transplantation
Joanna Sophia J Vinke, Marith I Francke, Michele F Eisenga, Dennis A Hesselink, Martin H de Borst
Iron deficiency (ID) is highly prevalent in kidney transplant recipients (KTRs) and has been independently associated with an excess mortality risk in this population. Several causes lead to ID in KTRs, including inflammation, medication and an increased iron need after transplantation. Although many studies in other populations indicate a pivotal role for iron as a regulator of the immune system, little is known about the impact of ID on the immune system in KTRs. Moreover, clinical trials in patients with chronic kidney disease or heart failure have shown that correction of ID, with or without anaemia, improves exercise capacity and quality of life, and may improve survival...
September 10, 2020: Nephrology, Dialysis, Transplantation
Swapnil Hiremath, Jennifer Kong, Edward G Clark
No abstract text is available yet for this article.
September 10, 2020: Nephrology, Dialysis, Transplantation
Sophie Liabeuf, Maurice Laville
No abstract text is available yet for this article.
September 9, 2020: Nephrology, Dialysis, Transplantation
Peter J Blankestijn, Annette Bruchfeld, Mario Cozzolino, Danilo Fliser, Denis Fouque, Ron Gansevoort, Dimitrios Goumenos, Ziad A Massy, Ivan Rychlık, Maria Jose Soler, Kate Stevens, Carmine Zoccali
No abstract text is available yet for this article.
September 9, 2020: Nephrology, Dialysis, Transplantation
Hiroaki Ogata, Naoko Shimofurutani, Tadashi Okada, Hisashi Nagamoto, Tadao Akizawa
BACKGROUND: Loop diuretics are used to manage fluid retention in patients with end-stage kidney disease undergoing hemodialysis (HD). This randomized, double-blind, placebo-controlled, Phase 2 trial evaluated the efficacy and safety of tolvaptan, a vasopressin V2 receptor antagonist, in Japanese HD patients. METHODS: A total of 124 patients (24-h urine volume ≥500 mL) on thrice-weekly HD were randomized to receive oral tolvaptan 15 mg/day (n = 40), tolvaptan 30 mg/day (n = 40) or placebo (n = 44) for 24 weeks...
September 9, 2020: Nephrology, Dialysis, Transplantation
Gregory L Hundemer, Anand Srivastava, Kirolos A Jacob, Neeraja Krishnasamudram, Salman Ahmed, Emily Boerger, Shreyak Sharma, Kapil K Pokharel, Sameer A Hirji, Marc Pelletier, Kassem Safa, Win Kulvichit, John A Kellum, Leonardo V Riella, David E Leaf
BACKGROUND: Acute kidney injury (AKI) is a key risk factor for chronic kidney disease in the general population, but has not been investigated in detail among renal transplant recipients (RTRs). We investigated the incidence, severity and risk factors for AKI following cardiac surgery among RTRs compared with non-RTRs with otherwise similar clinical characteristics. METHODS: We conducted a retrospective cohort study of RTRs (n = 83) and non-RTRs (n = 83) who underwent cardiac surgery at two major academic medical centers...
September 6, 2020: Nephrology, Dialysis, Transplantation
Hassan Izzedine, Kenar D Jhaveri
No abstract text is available yet for this article.
September 5, 2020: Nephrology, Dialysis, Transplantation
Carmine Zoccali, Raymond Vanholder, Carsten A Wagner, Hans-Joachim Anders, Peter J Blankestijn, Annette Bruchfeld, Giovambattista Capasso, Mario Cozzolino, Friedo W Dekker, Danilo Fliser, Denis Fouque, Ron T Gansevoort, Dimitrios Goumenos, Kitty J Jager, Ziad A Massy, Tom A J Oostrom, Ivan Rychlık, Maria Jose Soler, Kate Stevens, Goce Spasovski, Christoph Wanner
Medical societies have a social responsibility to disseminate knowledge and inform health authorities on threats to public health posed by various diseases. Advocacy for health protection programmes and for medical research funding is now embedded into the missions of most scientific societies. To promote kidney research funding in Europe, the European Renal Association - European Dialysis and Transplant Association (ERA-EDTA), rather than acting as an individual society advocating for the fight against kidney disease, has actively helped to create an alliance of national associations centred on kidney diseases, the European Kidney Health Alliance (EKHA), and joined the Biomedical Alliance (BMA)...
September 4, 2020: Nephrology, Dialysis, Transplantation
Loreto Fernandez-Lorente, Paloma L Martin-Moreno, Jesus Arteaga
No abstract text is available yet for this article.
September 3, 2020: Nephrology, Dialysis, Transplantation
Yasuhiro Ichida, Shuichi Ohtomo, Tessai Yamamoto, Naoaki Murao, Yoshinori Tsuboi, Yoshiki Kawabe, Hiroko Segawa, Naoshi Horiba, Ken-Ichi Miyamoto, Jürgen Floege
BACKGROUND: Phosphate is absorbed in the small intestine via passive flow and active transport.NaPi-IIb, a type II sodium-dependent phosphate transporter, is considered to mediate active phosphate transport in rodents. To study the regulation of intestinal phosphate transport in chronic kidney disease (CKD), we analyzed the expression levels of NaPi-IIb, pituitary-specific transcription factor 1 (PiT-1) and PiT-2 and the kinetics of intestinal phosphate transport using two CKD models...
September 3, 2020: Nephrology, Dialysis, Transplantation
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