Nephrology, Dialysis, Transplantation

Hyung Ah Jo, Dong Ki Kim, Seokwoo Park, Yaerim Kim, Seung Seok Han, Bo Ram Yang, So-Hyun Choi, Mi-Sook Kim, Joongyub Lee, Hajeong Lee, Jung Pyo Lee, Chun Soo Lim, Yon Su Kim, Kwon Wook Joo
BACKGROUND: Given the cardiovascular risk of nonsteroidal anti-inflammatory drugs (NSAIDs), it is essential to identify the relationship between NSAIDs and cardiovascular outcomes in dialysis patients who have elevated cardiovascular risk. METHODS: A case-crossover study was conducted to assess the association of NSAIDs with major adverse cardiac and cerebrovascular events (MACCEs) and mortality using the Korean Health Insurance dataset. The case period was defined as 1-30 days prior to the event date and the control periods were defined as 61-90 days and 91-120 days prior to the event date...
January 14, 2020: Nephrology, Dialysis, Transplantation
Cynthia J Janmaat, Merel van Diepen, Yvette Meuleman, Nicholas C Chesnaye, Christiane Drechsler, Claudia Torino, Christoph Wanner, Maurizio Postorino, Maciej Szymczak, Marie Evans, Fergus J Caskey, Kitty J Jager, Friedo W Dekker
BACKGROUND: Initiation of renal replacement therapy often results from a combination of kidney function deterioration and symptoms related to chronic kidney disease (CKD) progression. We investigated the association between kidney function decline and symptom development in patients with advanced CKD. METHODS: In the European Quality study on treatment in advanced CKD (EQUAL study), a European prospective cohort study, patients with advanced CKD aged ≥65 years and a kidney function that dropped <20 mL/min/1...
January 14, 2020: Nephrology, Dialysis, Transplantation
Markus Ketteler, Moritz Schanz, Severin Schricker
No abstract text is available yet for this article.
January 14, 2020: Nephrology, Dialysis, Transplantation
Nicole Bischof, Caroline Wehmeier, Michael Dickenmann, Patricia Hirt-Minkowski, Patrizia Amico, Jürg Steiger, Klaudia Naegele, Hans H Hirsch, Stefan Schaub
BACKGROUND: Cytomegalovirus (CMV) serostatus and CMV replication are considered as risk factors for inferior graft and patient survival after renal transplantation, but long-term outcome data are limited. The aim of this retrospective single-centre study was to investigate the impact of CMV serostatus and CMV replication/disease on long-term outcomes in a well-defined cohort managed by a standardized CMV prevention/treatment protocol. METHODS: We investigated 599 consecutive kidney transplantations having a CMV prevention protocol consisting of either prophylaxis (D+/R- and R+ with ATG induction) or screening/deferred therapy (R+ without ATG induction)...
January 14, 2020: Nephrology, Dialysis, Transplantation
Seraina von Moos, Stephan Segerer, Andrew Davenport, Malha Sadoune, Kerem Gerritsen, Julien Pottecher, Frank Ruschitzka, Alexandre Mebazaa, Mattia Arrigo, Pietro E Cippà
BACKGROUND: Improved understanding and assessment of the complex physiology of volume regulation in haemodialysis (HD) patients are required to improve patient care and reduce mortality associated with fluid overload (FO). METHODS: We searched for FO-related biomarkers among 184 peptides associated with cardiovascular disease in a cohort of 30 HD patients. First, we assessed the direct impact of HD on the peptides of interest by comparing plasma concentrations before and after treatment...
January 10, 2020: Nephrology, Dialysis, Transplantation
Francesca Mallamaci, Anna Pisano, Giovanni Tripepi
No abstract text is available yet for this article.
January 10, 2020: Nephrology, Dialysis, Transplantation
Karen Stevenson
No abstract text is available yet for this article.
January 9, 2020: Nephrology, Dialysis, Transplantation
Rianne W de Jong, Vianda S Stel, James G Heaf, Mark Murphy, Ziad A Massy, Kitty J Jager
BACKGROUND: Large international differences exist in access to renal replacement therapy (RRT) modalities and comprehensive conservative management (CCM) for patients with end-stage kidney disease (ESKD), suggesting that some patients are not receiving the most appropriate treatment. Previous studies mainly focused on barriers reported by patients or medical barriers (e.g. comorbidities) reported by nephrologists. An overview of the non-medical barriers reported by nephrologists when providing the most appropriate form of RRT (other than conventional in-centre haemodialysis) or CCM is lacking...
January 3, 2020: Nephrology, Dialysis, Transplantation
Suman Krishna Kotla, Pradeep V Kadambi, Allen R Hendricks, Rebecca Rojas
BK virus is a polyomavirus with seroprevalence rates of 80% in adults. Infection is usually acquired during childhood, and the virus is benign or pathologic depending on immune status. The virus reactivates in immunodeficiency states, mostly among transplant (either kidney or bone marrow) recipients. There are approximately 15 000 renal transplants every year in the USA, of which 5-10% develop BK polyomavirus nephropathy; 50-80% of patients who develop nephropathy go on to develop graft failure. BK virus is associated with BK polyomavirus nephropathy, ureteral stenosis, late-onset hemorrhagic cystitis, bladder cancer and other nonlytic large T-expressing carcinomas...
December 31, 2019: Nephrology, Dialysis, Transplantation
Masatoshi Nishimoto, Miho Murashima, Maiko Kokubu, Masaru Matsui, Masahiro Eriguchi, Ken-Ichi Samejima, Yasuhiro Akai, Kazuhiko Tsuruya
BACKGROUND: Little is known about the association between pre-operative proteinuria and post-operative acute kidney injury (AKI) in noncardiac surgery. METHODS: This is a retrospective cohort study. Adults who underwent noncardiac surgery under general anesthesia from 2007 to 2011 at Nara Medical University Hospital were included. Those with obstetric or urological surgery, missing data for analyses or pre-operative dialysis were excluded. Exposure of interest was pre-operative proteinuria, defined as (+) or more by dipstick test...
December 31, 2019: Nephrology, Dialysis, Transplantation
Christopher Carlos, Barbara Grimes, Mark Segal, Kirsten Johansen
BACKGROUND: Slow gait speed is associated with hospitalization and death. We examined whether predialysis fluid overload contributes to gait speed impairment. METHODS: We measured predialysis gait speed at baseline and 12 and 24 months among 298 patients recruited in the A Cohort Study to Investigate the Value of Exercise in ESRD/Analyses Designed to Investigate the Paradox of Obesity and Survival in ESRD. We used multivariable linear mixed modeling to examine associations between patient data and gait speed...
December 30, 2019: Nephrology, Dialysis, Transplantation
Ting Luo, Fengping Zheng, Kang Wang, Yong Xu, Huixuan Xu, Wenxi Shen, Chengxin Zhu, Xinzhou Zhang, Weiguo Sui, Donge Tang, Lianghong Yin, Yong Dai
BACKGROUND: Immune aberrations in end-stage renal disease (ESRD) are characterized by systemic inflammation and immune deficiency. The mechanistic understanding of this phenomenon remains limited. METHODS: We generated 12 981 and 9578 single-cell transcriptomes of peripheral blood mononuclear cells (PBMCs) that were pooled from 10 healthy volunteers and 10 patients with ESRD by single-cell RNA sequencing. Unsupervised clustering and annotation analyses were performed to cluster and identify cell types...
December 28, 2019: Nephrology, Dialysis, Transplantation
Rodrigo Rosado-Canto, Idalia Parra-Avila, Javier Tejeda-Maldonado, Cristopher Kauffman-Ortega, Francisco T Rodriguez-Covarrubias, Mariedel Trujeque-Matos, Rodrigo Cruz-Martínez, Ernesto Maravilla-Franco, Elia Criollo-Mora, José M Arreola-Guerra, Luis E Morales-Buenrostro, José Sifuentes-Osornio
BACKGROUND: Symptomatic urinary tract infection (UTI) is the most common infectious complication in renal transplant recipients (RTRs). Fosfomycin (FOS) is an attractive alternative for prophylaxis because it does not interact with immunosuppressants; although 90% is excreted unchanged in the urine, it does not require adjustment for renal function for single dose prophylaxis. METHODS: RTRs were recruited into this randomized, double-blind, placebo-controlled trial...
December 28, 2019: Nephrology, Dialysis, Transplantation
Sheila Bermejo, Clara García-Carro, María José Soler
No abstract text is available yet for this article.
December 28, 2019: Nephrology, Dialysis, Transplantation
Rosanna Coppo, Christophe Mariat
No abstract text is available yet for this article.
December 20, 2019: Nephrology, Dialysis, Transplantation
Mark E Thomas, Tarek S Abdelaziz, Gavin D Perkins, Alice J Sitch, Jyoti Baharani, R Mark Temple
BACKGROUND AND OBJECTIVES: The Acute Kidney Outreach to Reduce Deterioration and Death trial was a large pilot study for a cluster-randomized trial of acute kidney injury (AKI) outreach. METHODS: An observational control (before) phase was conducted in two teaching hospitals (9 miles apart) and their respective catchment areas. In the intervention (after) phase, a working-hours AKI outreach service operated for the intervention hospital/area for 20 weeks, with the other site acting as a control...
December 20, 2019: Nephrology, Dialysis, Transplantation
Giovanni Tripepi, Graziella D'Arrigo, Francesca Mallamaci, Gerard London, Navdeep Tangri, Jesse Yenchih Hsu, Harvey Feldman, Carmine Zoccali
BACKGROUND: Left ventricular hypertrophy is causally implicated in the high risk of death and heart failure (HF) in chronic kidney disease (CKD) patients. Whether the left ventricular mass index (LVMI) adds meaningful predictive power for mortality and de novo HF to simple risk models has not been tested in the CKD population. METHODS: We investigated this problem in 1352 CKD patients enrolled in the Chronic Renal Insufficiency Cohort (CRIC). LVMI was measured by echocardiography and the risks for death and HF were estimated by the Study of Heart and Renal Protection (SHARP) score, a well-validated risk score in CKD patients...
December 20, 2019: Nephrology, Dialysis, Transplantation
Nadia M Chu, Stephanie Sison, Abimereki D Muzaale, Christine E Haugen, Jacqueline M Garonzik-Wang, Daniel C Brennan, Silas P Norman, Dorry L Segev, Mara McAdams-DeMarco
BACKGROUND: Approximately half of the patients who progress to end-stage kidney disease (ESKD) and undergo dialysis develop difficulties carrying out essential self-care activities, leading to institutionalization and mortality. It is unclear what percentage of kidney transplant (KT) candidates, a group of ESKD patients selected to be healthy enough to withstand transplantation, are functionally independent and whether independence is associated with better access to KT and reduced waitlist mortality...
December 20, 2019: Nephrology, Dialysis, Transplantation
Shane A Bobart, Mariam P Alexander, Khaled Shawwa, Lisa E Vaughan, Ranine Ghamrawi, Sanjeev Sethi, Lynn Cornell, Richard J Glassock, Fernando C Fervenza, Ladan Zand
BACKGROUND: Microhematuria is common in immunoglobulin A nephropathy (IgAN). However, current prognostication is based on proteinuria and mesangial hypercellularity, endocapillary hypercellularity, segmental sclerosis, tubulointerstitial fibrosis and crescent (MEST-C) scores. METHODS: In this retrospective study, we evaluated whether MEST-C score components are associated with the presence of microhematuria at biopsy and whether the degree of microhematuria during follow-up is associated with change in estimated glomerular filtration rate (eGFR), after adjusting for clinical and histological parameters...
December 20, 2019: Nephrology, Dialysis, Transplantation
Irene Ruderman, Nigel D Toussaint, Carmel M Hawley, Rathika Krishnasamy, Eugenia Pedagogos, Nicole Lioufas, Grahame J Elder
BACKGROUND: Calciphylaxis is a rare disease, predominantly affecting patients with chronic kidney disease (CKD) and associated with significant morbidity and mortality due to progressive cutaneous calcification, necrotic ulceration and infection. Clinical registries have been established to better understand the risk factors, optimal treatments and disease outcomes of calciphylaxis. METHODS: We established a prospective, Internet-based clinical registry for the online notification of calciphylaxis cases in Australia...
December 19, 2019: Nephrology, Dialysis, Transplantation
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