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Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc

journal
https://read.qxmd.com/read/30778169/whole-slide-imaging-equivalency-and-efficiency-study-experience-at-a-large-academic-center
#1
Matthew G Hanna, Victor E Reuter, Meera R Hameed, Lee K Tan, Sarah Chiang, Carlie Sigel, Travis Hollmann, Dilip Giri, Jennifer Samboy, Carlos Moradel, Andrea Rosado, John R Otilano, Christine England, Lorraine Corsale, Evangelos Stamelos, Yukako Yagi, Peter J Schüffler, Thomas Fuchs, David S Klimstra, S Joseph Sirintrapun
Whole slide imaging is Food and Drug Administration-approved for primary diagnosis in the United States of America; however, relatively few pathology departments in the country have fully implemented an enterprise wide digital pathology system enabled for primary diagnosis. Digital pathology has significant potential to transform pathology practice with several published studies documenting some level of diagnostic equivalence between digital and conventional systems. However, whole slide imaging also has significant potential to disrupt pathology practice, due to the differences in efficiency of manipulating digital images vis-à-vis glass slides, and studies on the efficiency of actual digital pathology workload are lacking...
February 18, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30765881/knowledge-gaps-in-the-appendix-a-multi-institutional-study-from-seven-academic-centers
#2
Christina A Arnold, Rondell P Graham, Dhanpat Jain, Sanjay Kakar, Dora M Lam-Himlin, Bita V Naini, Tsung-Teh Wu, Matthew M Yeh, Michael S Torbenson
Appendix pathology represents uncommonly encountered specimens with unique diagnostic challenges. To delineate common knowledge gaps, extramural consults submitted to seven institutions between 2016-2017 were reviewed. All appendix consults were resections (100%, n = 43), and the majority were directed for consultation by the originating pathologist (95%, n = 41) with no additional studies performed by the consultant (65%, n = 28). This study was dominated by inquiries related to low grade appendiceal mucinous neoplasms (44%, n = 19) and goblet cell carcinoid related neoplasms (19%, n = 8)...
February 14, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30765880/characteristics-of-mismatch-repair-deficiency-in-sarcomas
#3
Leona A Doyle, Jonathan A Nowak, Michael J Nathenson, Katherine Thornton, Andrew J Wagner, Jason M Johnson, Adem Albrayak, Suzanne George, Lynette M Sholl
Due to the efficacy of immune checkpoint inhibitor therapy in tumors with deficient mismatch repair, there has been a surge in demand for mismatch repair deficiency testing in various tumor types. Mismatch repair deficiency is not known to play a significant role in the pathogenesis of sarcomas, and the utility of testing these tumor types is not established. This study aimed to determine the frequency, pattern, and clinicopathologic correlates of mismatch repair deficiency in sarcomas. Three hundred and four sarcomas were profiled using a genomic platform that employs massively parallel sequencing to interrogate 447 cancer-associated genes...
February 14, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30760860/immunohistochemical-detection-of-pd-l1-among-diverse-human-neoplasms-in-a-reference-laboratory-observations-based-upon-62-896-cases
#4
Dennis P O'Malley, Yuhang Yang, Saskia Boisot, Sucha Sudarsanam, Jian-Feng Wang, Vladislav Chizhevsky, Guohua Zhao, Shehla Arain, Lawrence M Weiss
Targeting of the PD1/PD-L1 immune checkpoint pathway has rapidly gained acceptance as a therapeutic strategy for a growing number of malignancies. Testing for expression of PD-L1 in tumor cells and immune cells has been used as a companion or complementary test for drugs targeting the PD1/PD-L1 pathway. We evaluated the results of PD-L1 testing in a large reference lab cohort. Using Food and Drug Administration-approved methods and interpretive instructions for each individual test, 62,896 cases were evaluated for PD-L1 using antibody clone 22C3, 28-8, SP142, or SP263...
February 13, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30760859/ductal-carcinoma-in-situ-of-the-breast-an-update-for-the-pathologist-in-the-era-of-individualized-risk-assessment-and-tailored-therapies
#5
REVIEW
Wedad M Hanna, Carlos Parra-Herran, Fang-I Lu, Elzbieta Slodkowska, Eileen Rakovitch, Sharon Nofech-Mozes
Ductal carcinoma in situ (DCIS) is a neoplastic proliferation of mammary ductal epithelial cells confined to the ductal-lobular system, and a non-obligate precursor of invasive disease. While there has been a significant increase in the diagnosis of DCIS in recent years due to uptake of mammography screening, there has been little change in the rate of invasive recurrence, indicating that a large proportion of patients diagnosed with DCIS will never develop invasive disease. The main issue for clinicians is how to reliably predict the prognosis of DCIS in order to individualize patient treatment, especially as treatment ranges from surveillance only, breast-conserving surgery only, to breast-conserving surgery plus radiotherapy and/or hormonal therapy, and mastectomy with or without radiotherapy...
February 13, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30760858/primary-malignant-melanoma-of-esophagus-clinicopathologic-characterization-of-20-cases-including-molecular-genetic-profiling-of-15-tumors
#6
Jerzy Lasota, Artur Kowalik, Anna Felisiak-Golabek, Sebastian Zięba, Piotr Waloszczyk, Marek Masiuk, Jaroslaw Wejman, Justyna Szumilo, Markku Miettinen
Primary malignant melanoma of esophagus is very rare, and its clinicopathologic and genetic features have not been extensively investigated. In this study, 20 tumors from 14 male and 6 female patients (40-79 years old) were evaluated. Dysphagia, chest pain, and weight loss were frequent symptoms. Thirteen melanomas, including two with multiple lesions, involved the distal third of esophagus. The median tumor diameter was 6 cm. Epithelioid morphology, moderate atypia, and pigmentation were typical findings...
February 13, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30760857/the-molecular-mechanisms-underlying-reduced-e-cadherin-expression-in-invasive-ductal-carcinoma-of-the-breast-high-throughput-analysis-of-large-cohorts
#7
Mansour Alsaleem, Michael S Toss, Chitra Joseph, Mohammed Aleskandarany, Sasagu Kurozumi, Ibrahim Alshankyty, Angela Ogden, Padmashree C G Rida, Ian O Ellis, Ritu Aneja, Andrew R Green, Nigel P Mongan, Emad A Rakha
E-cadherin is a tumor suppressor gene in invasive lobular breast cancer. However, a proportion of high-grade ductal carcinoma shows reduced/loss of E-cadherin. In this study, we assessed the underlying mechanisms and molecular implications of E-cadherin loss in invasive ductal carcinoma. This study used large, well-characterized cohorts of early-stage breast cancer-evaluated E-cadherin expression via various platforms including immunohistochemistry, microarray analysis using Illumina HT-12 v3, copy number analysis using Affymetrix SNP 6...
February 13, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30742011/impact-of-tp53-immunohistochemistry-on-the-histological-grading-system-for-endometrial-endometrioid-carcinoma
#8
Mitsutake Yano, Kozue Ito, Akira Yabuno, Naoki Ogane, Tomomi Katoh, Mariko Miyazawa, Masaki Miyazawa, Kosei Hasegawa, Hisashi Narahara, Masanori Yasuda
Endometrial endometrioid carcinoma is usually divided into three histological subgroups: grade 1 (G1), grade 2 (G2), and grade 3 (G3). Most cases of endometrial endometrioid carcinoma G1/2 have a favorable prognosis, although some can have unfavorable outcomes, especially when they involve elderly patients, with similarities to endometrioid carcinoma G3 and serous carcinoma. This retrospective study evaluated whether TP53 abnormalities in endometrial endometrioid carcinoma could be used to supplement the current grading system and improve its ability to predict clinical outcomes...
February 11, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30737471/oncoproteomic-and-gene-expression-analyses-identify-prognostic-biomarkers-for-second-primary-malignancy-in-patients-with-head-and-neck-squamous-cell-carcinoma
#9
Sacarin Bunbanjerdsuk, Nutchavadee Vorasan, Thammakorn Saethang, Tanjitti Pongrujikorn, Duangjai Pangpunyakulchai, Narongsak Mongkonsiri, Lalida Arsa, Nintita Thokanit, Warut Pongsapich, Tauangtham Anekpuritanang, Nuttapong Ngamphaiboon, Artit Jinawath, Somkiat Sunpaweravong, Trairak Pisitkun, Bhoom Suktitipat, Natini Jinawath
Patients with head and neck squamous cell carcinoma are at increased risk of developing a second primary malignancy, which is associated with poor prognosis and early death. To help improve clinical outcome, we aimed to identify biomarkers for second primary malignancy risk prediction using the routinely obtained formalin-fixed paraffin-embedded tissues of the index head and neck cancer. Liquid chromatography-tandem mass spectrometry was initially performed for candidate biomarker discovery in 16 pairs of primary cancer tissues and their matched normal mucosal epithelia from head and neck squamous cell carcinoma patients with or without second primary malignancy...
February 8, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30737470/specific-immune-cell-and-lymphatic-vessel-signatures-identified-by-image-analysis-in-renal-cancer
#10
Peter Schraml, Maria Athelogou, Thomas Hermanns, Ralf Huss, Holger Moch
Anti-angiogenic therapy and immune checkpoint inhibition are novel treatment strategies for patients with renal cell carcinoma. Various components and structures of the tumor microenvironment are potential predictive biomarkers and also attractive treatment targets. Macrophages, tumor infiltrating lymphocytes, vascular and lymphatic vessels represent an important part of the tumor immune environment, but their functional phenotypes and relevance for clinical outcome are yet ill defined. We applied Tissue Phenomics methods including image analysis for the standardized quantification of specific components and structures within the tumor microenvironment to profile tissue sections from 56 clear cell renal cell carcinoma patients...
February 8, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30737469/three-dimensional-analysis-reveals-two-major-architectural-subgroups-of-prostate-cancer-growth-patterns
#11
Esther I Verhoef, Wiggert A van Cappellen, Johan A Slotman, Gert-Jan Kremers, Patricia C Ewing-Graham, Adriaan B Houtsmuller, Martin E van Royen, Geert J L H van Leenders
The Gleason score is one of the most important parameters for therapeutic decision-making in prostate cancer patients. Gleason growth patterns are defined by their histological features on 4- to 5-µm cross sections, and little is known about their three-dimensional architecture. Our objective was to characterize the three-dimensional architecture of prostate cancer growth patterns. Intact tissue punches (n = 46) of representative Gleason growth patterns from radical prostatectomy specimens were fluorescently stained with antibodies targeting Keratin 8/18 and Keratin 5 for the detection of luminal and basal epithelial cells, respectively...
February 8, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30723300/nutm1-rearranged-neoplasia-a-multi-institution-experience-yields-novel-fusion-partners-and-expands-the-histologic-spectrum
#12
Todd M Stevens, Diana Morlote, Joanne Xiu, Jeffrey Swensen, Margaret Brandwein-Weber, Markku M Miettinen, Zoran Gatalica, Julia A Bridge
Poorly differentiated neoplasms lacking characteristic histopathologic features represent a significant challenge to the pathologist for diagnostic classification. Classically, NUT carcinoma (previously NUT midline carcinoma) is poorly differentiated but typically exhibits variable degrees of squamous differentiation. Diagnosis is genetically defined by NUTM1 rearrangement, usually with BRD4 as the fusion partner. In this multi-institutional next-generation sequencing and fluorescence in situ hybridization study, 26 new NUTM1-rearranged neoplasms are reported, including 20 NUT carcinomas, 4 sarcomas, and 2 tumors of an uncertain lineage...
February 5, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30723299/combined-prognostic-value-of-cd274-pd-l1-pdcdi-pd-1-expression-and-immune-cell-infiltration-in-colorectal-cancer-as-per-mismatch-repair-status
#13
Maarit Ahtiainen, Erkki-Ville Wirta, Teijo Kuopio, Toni Seppälä, Juha Rantala, Jukka-Pekka Mecklin, Jan Böhm
The CD274 (programmed cell death ligand-1, PD-L1)/PDCD1 (programmed cell death-1, PD-1) pathway is crucial suppressor of the cytotoxic immune response. Antibodies targeting CD274 or PDCD1 have been revealed to be effective in several malignancies. In colorectal cancer, the response to CD274/PDCD1 blockage is associated with microsatellite instability. However, the value of CD274/PDCD1 for predicting response to treatment or survival benefit is still unclear. The aims of the study were (1) to clarify differences in immune microenvironment and expression of checkpoint proteins (CD274/PDCD1) in DNA mismatch repair-proficient, mismatch repair-deficient, and hereditary Lynch syndrome-associated colorectal cancer, and (2) to assess the prognostic value of these factors and their combinations...
February 5, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30723298/the-value-of-axillary-skin-electron-microscopic-analysis-in-the-diagnosis-of-lysosomal-storage-disorders
#14
Manuela Zlamy, Justina Hofstätter, Ursula Albrecht, Sara Baumgartner, Edda Haberlandt, Sabine Scholl-Bürgi, Doris Guntersweiler, Michael Reinehr, Daniela Mihic-Probst, Daniela Karall
Both lysosomal storage diseases and mitochondrial diseases are a group of genetic-inherited metabolic disorders. In an era, where "old fashioned methods" are apparently being replaced by evolving molecular techniques (i.e. exome and whole genome sequencing), the "old fashioned methods" might help to characterise and thus narrow down the potential differential diagnosis. Therefore, we retrospectively evaluated the relevance of electron microscopy of axillary skin for the diagnosis of lysosomal storage or mitochondrial diseases (=inherited metabolic disorders of energy metabolism)...
February 5, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30723297/prevalence-of-recurrent-oncogenic-fusion-in-mismatch-repair-deficient-colorectal-carcinoma-with-hypermethylated-mlh1-and-wild-type-braf-and-kras
#15
Jing Wang, Yuting Yi, Yi Xiao, Lin Dong, Li Liang, Lianghong Teng, Jian Ming Ying, Tao Lu, Yuanyuan Liu, Yanfang Guan, Junyi Pang, Lianrui Zhou, Junliang Lu, Zhiwen Zhang, Xiaoding Liu, Xiaolong Liang, Xuan Zeng, Xin Yi, Weixun Zhou, Xuefeng Xia, Ling Yang, Jianjun Zhang, Scott Kopetz, P Andrew Futreal, Huanwen Wu, Zhiyong Liang
Oncogenic fusions are rare in colorectal carcinomas, but may be important for prognosis and therapy. An effective strategy for screening targetable oncogenic fusions in colorectal carcinomas is needed. Here, we investigate molecular genetic alterations in colorectal carcinomas based on their DNA mismatch repair status, and to effectively screen for targetable oncogenic fusions in colorectal carcinomas. In this retrospective study, the initial cohort included 125 consecutive mismatch repair-deficient and 238 randomly selected mismatch repair-proficient colorectal carcinomas diagnosed between July 2015 and December 2017 at Peking Union Medical College Hospital...
February 5, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30723296/dna-methylation-profiling-reliably-distinguishes-pulmonary-enteric-adenocarcinoma-from-metastatic-colorectal-cancer
#16
Philipp Jurmeister, Anne Schöler, Alexander Arnold, Frederick Klauschen, Dido Lenze, Michael Hummel, Leonille Schweizer, Hendrik Bläker, Berit Maria Pfitzner, Soulafa Mamlouk, Christine Sers, Carsten Denkert, Damian Stichel, Nikolaj Frost, David Horst, Maximilian von Laffert, David Capper
Pulmonary enteric adenocarcinoma is a rare non-small cell lung cancer subtype. It is poorly characterized and cannot be distinguished from metastatic colorectal or upper gastrointestinal adenocarcinomas by means of routine pathological methods. As DNA methylation patterns are known to be highly tissue specific, we aimed to develop a methylation-based algorithm to differentiate these entities. To this end, genome-wide methylation profiles of 600 primary pulmonary, colorectal, and upper gastrointestinal adenocarcinomas obtained from The Cancer Genome Atlas and the Gene Expression Omnibus database were used as a reference cohort to train a machine learning algorithm...
February 5, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30723295/update-on-the-pathologic-diagnosis-of-chronic-myelomonocytic-leukemia
#17
REVIEW
Daniel A Arber, Attilio Orazi
The diagnostic criteria for chronic myelomonocytic leukemia were recently revised in the 2016 World Health Organization classification update and include new and revised subtypes. In addition, molecular genetic studies have provided new insights into the prognosis and diagnosis of this myeloid neoplasm. This review summarizes the 2016 changes to the diagnostic criteria, discusses potential future changes that may impact diagnosis and provides an overview of recent advances in the diagnosis and prognosis determination of chronic myelomonocytic leukemia...
February 5, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30723294/angiosarcoma-and-anaplastic-carcinoma-of-the-thyroid-are-two-distinct-entities-a-morphologic-immunohistochemical-and-genetic-study
#18
Elisabetta Kuhn, Moira Ragazzi, Alessia Ciarrocchi, Federica Torricelli, Dario de Biase, Eleonora Zanetti, Alessandra Bisagni, Stefania Corrado, Silvia Uccella, Stefano La Rosa, Massimo Bongiovanni, Simona Losito, Simonetta Piana
Angiosarcoma and anaplastic carcinoma are the most lethal neoplasms of the thyroid worldwide and share some similarities, which have led to a longstanding controversy on their etiopathological relationship. Thyroid angiosarcomas are characterized by vessel formation and an immunophenotype common to endothelial cells, while anaplastic carcinomas are partially or wholly composed of mesenchymal-like cells that have lost the morphologic and functional features of normal thyroid follicular cells. To investigate whether angiosarcomas represent the endothelial extreme of the differentiation spectrum of carcinomas or they are bona fide vascular neoplasms, we studied the clinico-morphologic and genetic characteristics of a series of 10 angiosarcomas and 22 anaplastic carcinomas...
February 5, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30723293/metaplastic-breast-carcinoma-a-clinical-pathologic-study-of-97-cases-with-subset-analysis-of-response-to-neoadjuvant-chemotherapy
#19
Min Han, Arsalan Salamat, Li Zhu, Huina Zhang, Beth Z Clark, David J Dabbs, Gloria J Carter, Adam M Brufsky, Rachel C Jankowitz, Shannon L Puhalla, Ronald R Johnson, Atilla Soran, Jennifer G Steiman, Priscilla F McAuliffe, Emilia J Diego, Rohit Bhargava
Metaplastic breast carcinoma is a rare heterogeneous category of breast cancer, often associated with a poor prognosis. Clinical-pathologic studies with respect to varied morphologic subtypes are lacking. There is also a dearth of studies assessing the response of metaplastic breast carcinoma to neoadjuvant chemotherapy. Cases of metaplastic breast carcinoma diagnosed between 2007 and 2017 were identified. Various clinical-pathologic variables were tested for association with survival. Patients who underwent neoadjuvant chemotherapy were assessed for pathologic response...
February 5, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/30723292/phenotypical-diversity-of-airway-morphology-in-chronic-lung-graft-vs-host-disease-after-stem-cell-transplantation
#20
Stijn E Verleden, John E McDonough, Helene Schoemans, Christiane Knoop, Johny Verschakelen, Adriana Dubbeldam, Matthieu N Boone, Luc Van Hoorebeke, Erik Verbeken, Birgit Weynand, Dirk Van Raemdonck, Geert M Verleden, Robin Vos, Bart M Vanaudenaerde
Pulmonary graft vs. host disease is a diverse and underestimated complication following allogenic hematopoietic stem cell transplantation. We aimed to compare the airway architecture with chronic lung allograft dysfunction post lung transplantation. Inflated explant lungs from graft vs. host disease patients were compared with lungs with chronic lung allograft dysfunction following lung transplantation, and control lungs using a combination of CT, microCT, and histology (n = 6 per group) and pathology in the (small) airways was further quantified and analyzed...
February 5, 2019: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
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