Shih-Chiang Huang, Jen-Chieh Lee, Yong-Chen Hsu, Jen-Wei Tsai, Yu-Chien Kao, Tsung-Han Hsieh, Yi-Ming Chang, Kung-Chao Chang, Pao-Shu Wu, Paul Chih-Hsueh Chen, Chien-Heng Chen, Ching-Di Chang, Pei-Hang Lee, Hui-Chun Tai, Ting-Ting Liu, Mei-Chin Wen, Wan-Shan Li, Shih-Chen Yu, Jui-Chu Wang, Hsuan-Ying Huang
Extraskeletal myxoid chondrosarcoma (EMC) is an ultrarare sarcoma typically exhibiting myxoid/reticular histology and NR4A3 translocation. However, morphologic variants and the relevance of non-EWSR1::NR4A3 fusions remain underexplored. Three challenging pan-Trk-expressing cases, featuring cellular to solid histology, were subjected to RNA exome sequencing (RES), unveiling different NR4A3-associated fusions. Alongside RES-analyzed cases, fluorescence in situ hybridization was performed to confirm 58 EMCs, with 48 available for pan-Trk immunostaining and KIT sequencing...
March 20, 2023: Modern Pathology