Robert A Dowden, Paul J Wisniewski, Candace R Longoria, Marko Oydanich, Tara McNulty, Esther Rodriguez, Jie Zhang, Mark Cavallo, John J Guers, Dorothy E Vatner, Stephen F Vatner, Sara C Campbell
PURPOSE: We investigated the effects of gut microbes, and the mechanisms mediating the enhanced exercise performance induced by exercise training, i.e., skeletal muscle blood flow, and mitochondrial biogenesis and oxidative function in male mice. METHODS: All mice received a graded exercise test prior to (PRE) and following exercise training via forced treadmill running at 60-70% of maximal running capacity 5 d/wk for 5 weeks (POST). To examine the role of the gut microbes, the graded exercise was repeated after 7 days of access to antibiotic treated water (ABX), used to eliminate gut microbes...
March 14, 2023: Medicine and Science in Sports and Exercise