journal
https://read.qxmd.com/read/38902674/detection-of-duffy-blood-group-genotypes-and-submicroscopic-plasmodium-infections-using-molecular-diagnostic-assays-in-febrile-malaria-patients
#1
JOURNAL ARTICLE
Beka R Abagero, Rei Rama, Abdulghani Obeid, Tirusew Tolosa, Biniyam Lukas, Taye Teka, Daniel Tesfaye, Eugenia Lo, Delenasaw Yewhalaw
BACKGROUND: Malaria remains a severe parasitic disease, posing a significant threat to public health and hindering economic development in sub-Saharan Africa. Ethiopia, a malaria endemic country, is facing a resurgence of the disease with a steadily rising incidence. Conventional diagnostic methods, such as microscopy, have become less effective due to low parasite density, particularly among Duffy-negative human populations in Africa. To develop comprehensive control strategies, it is crucial to generate data on the distribution and clinical occurrence of Plasmodium vivax and Plasmodium falciparum infections in regions where the disease is prevalent...
June 20, 2024: Malaria Journal
https://read.qxmd.com/read/38898518/assessing-crispr-cas9-potential-in-sdg3-attainment-malaria-elimination-regulatory-and-community-engagement-landscape
#2
REVIEW
Aleksandra Snuzik
Elimination of malaria has become a United Nations member states target: Target 3.3 of the sustainable development goal no. 3 (SDG3). Despite the measures taken, the attainment of this goal is jeopardized by an alarming trend of increasing malaria case incidence. Globally, there were an estimated 241 million malaria cases in 2020 in 85 malaria-endemic countries, increasing from 227 million in 2019. Malaria case incidence was 59, which means effectively no changes in the numbers occurred, compared with the baseline 2015...
June 19, 2024: Malaria Journal
https://read.qxmd.com/read/38898414/predictors-of-insecticide-treated-bed-nets-use-among-pregnant-women-in-sierra-leone-evidence-from-the-2019-sierra-leone-demographic-health-survey
#3
JOURNAL ARTICLE
Augustus Osborne, Camilla Bangura
BACKGROUND: Malaria remains a significant public health threat in Sierra Leone, particularly for pregnant women and their unborn children. Infection during pregnancy can lead to severe consequences, including maternal anaemia, low birth weight, premature birth, and even death. Therefore, preventing malaria during pregnancy is crucial for improving maternal and child health outcomes. This study investigated the predictors of insecticide-treated bed net (ITN) use among pregnant women in Sierra Leone...
June 19, 2024: Malaria Journal
https://read.qxmd.com/read/38886782/llin-evaluation-in-uganda-project-llineup2-association-between-housing-construction-and-malaria-burden-in-32-districts
#4
JOURNAL ARTICLE
Samuel Gonahasa, Martha Nassali, Catherine Maiteki-Sebuguzi, Jane F Namuganga, Jimmy Opigo, Isaiah Nabende, Jaffer Okiring, Adrienne Epstein, Katherine Snyman, Joaniter I Nankabirwa, Moses R Kamya, Grant Dorsey, Sarah G Staedke
BACKGROUND: Well-built housing limits mosquito entry and can reduce malaria transmission. The association between community-level housing and malaria burden in Uganda was assessed using data from randomly selected households near 64 health facilities in 32 districts. METHODS: Houses were classified as 'improved' (synthetic walls and roofs, eaves closed or absent) or 'less-improved' (all other construction). Associations between housing and parasitaemia were made using mixed effects logistic regression (individual-level) and multivariable fractional response logistic regression (community-level), and between housing and malaria incidence using multivariable Poisson regression...
June 17, 2024: Malaria Journal
https://read.qxmd.com/read/38886766/the-unseen-battle-interpreting-the-2023-world-malaria-report-from-burkina-faso-s-frontlines
#5
LETTER
Etienne Bilgo
The recently released 2023 World Malaria Report sheds light on an alarming reality: despite preventive measures, malaria remains a severe issue in Burkina Faso. As researchers in the field working on malaria in Burkina Faso, the assessment suggests significant underreporting, especially in remote areas with limited healthcare access. In addition, the confusion arising from similar diseases, such as dengue, further complicates the situation. Aligning with the 2023 World Health Organization recommendations, it is time to advocate for tailored strategies in high-burden areas by emphasizing community involvement in data collection awareness campaigns for effective disease management to combat the invisible crisis lurking within communities...
June 17, 2024: Malaria Journal
https://read.qxmd.com/read/38880891/space-time-clusters-and-co-occurrence-of-plasmodium-vivax-and-plasmodium-falciparum-malaria-in-west-bengal-india
#6
JOURNAL ARTICLE
Meghna Maiti, Utpal Roy
BACKGROUND: Malaria, a prominent vector borne disease causing over a million annual cases worldwide, predominantly affects vulnerable populations in the least developed regions. Despite their preventable and treatable nature, malaria remains a global public health concern. In the last decade, India has faced a significant decline in malaria morbidity and mortality. As India pledged to eliminate malaria by 2030, this study examined a decade of surveillance data to uncover space-time clustering and seasonal trends of Plasmodium vivax and Plasmodium falciparum malaria cases in West Bengal...
June 17, 2024: Malaria Journal
https://read.qxmd.com/read/38880870/screening-of-malaria-infections-in-human-blood%C3%A2-samples-with-varying-parasite-densities-and-anaemic-conditions-using-ai-powered-mid-infrared-spectroscopy
#7
JOURNAL ARTICLE
Issa H Mshani, Frank M Jackson, Rehema Y Mwanga, Prisca A Kweyamba, Emmanuel P Mwanga, Mgeni M Tambwe, Lorenz M Hofer, Doreen J Siria, Mario González-Jiménez, Klaas Wynne, Sarah J Moore, Fredros Okumu, Simon A Babayan, Francesco Baldini
BACKGROUND: Effective testing for malaria, including the detection of infections at very low densities, is vital for the successful elimination of the disease. Unfortunately, existing methods are either inexpensive but poorly sensitive or sensitive but costly. Recent studies have shown that mid-infrared spectroscopy coupled with machine learning (MIRs-ML) has potential for rapidly detecting malaria infections but requires further evaluation on diverse samples representative of natural infections in endemic areas...
June 17, 2024: Malaria Journal
https://read.qxmd.com/read/38879484/a-five-years-malaria-surveillance-data-analysis-of-north-shewa-zone-amhara-region-ethiopia-july-2018-to-june-2023
#8
JOURNAL ARTICLE
Tebabere Moltot, Girma Bekele, Zenebe Abebe Gebreegziabher, Tesfansh Lemma, Moges Sisay, Mulualem Silesh, Melkam Mulugeta, Legesse Demissie, Tirusew Nigussie Kebede, Birhan Tsegaw Taye
BACKGROUND: Malaria is a critical public health concern in Ethiopia, with significant socioeconomic consequences. Malaria data trend analysis is essential for understanding transmission patterns and adopting evidence-based malaria control measures. The purpose of this study was to determine the 5 year distribution of malaria in North Shewa zone, Amhara region, Ethiopia, in 2023. METHODS: A descriptive cross-sectional study design was employed to analyse the 5 year trend of malaria surveillance data in the North Shewa zone of the Amhara regional, Ethiopia, spanning from July 2018 to June 2023...
June 15, 2024: Malaria Journal
https://read.qxmd.com/read/38872182/core-principles-of-malakit-intervention-for-transferability-in-other-contexts
#9
REVIEW
Maylis Douine, Yann Lambert, Muriel Suzanne Galindo, Irene Jimeno Maroto, Teddy Bardon, Lorraine Plessis, Louise Mutricy, Jane Bordallo-Miller, Mathieu Nacher, Antoine Adenis, Hedley Cairo, Hélène Hiwat, Stephen Vreden, Carlotta Carboni, Alice Sanna, Martha Suarez-Mutis
To eliminate malaria, all populations must be included. For those who are not reached by the health care system, specific interventions must be tailor-made. An innovative Malakit strategy, based on the distribution of self-diagnosis and self-treatment kits, has been evaluated in the Suriname-French Guiana- Amapá (Brazil) region. The results showed effectiveness and good acceptability. The Malakit intervention is complex and has many components. Its transferability requires adaptation to other populations and regions, while retaining the main features of the intervention...
June 13, 2024: Malaria Journal
https://read.qxmd.com/read/38872178/prognostics-of-multiple-malaria-episodes-and-nutritional-status-in-children-aged-6-to-59%C3%A2-months-from-2013-to-2017-in-dangassa-koulikoro-region-mali
#10
JOURNAL ARTICLE
Soumba Keita, Oumar Thiero, Mahamoudou Toure, Fousseyni Kane, Moussa Keita, Ibrahim Sanogo, Drissa Konate, Daouda Sanogo, Sory Ibrahim Diawara, Hamady Coulibaly, Sidibé M 'Baye Thiam, Nafomon Sogoba, Mahamadou Diakite, Seydou Doumbia
BACKGROUND: In Africa, the relationship between childhood nutritional status and malaria remains complex and difficult to interpret. Understanding it is important in the improvement of malaria control strategies. This study aimed to assess the influence of nutritional status on the occurrence of multiple malaria episodes in children aged 6 to 59 months between 2013 and 2017 living in the village of Dangassa, Mali. METHODS: A community-based longitudinal study was conducted using cross-sectional surveys (CSSs) at the beginning (June) and end (November) of the malaria transmission season associated with passive case detection (PCD) at the Dangassa Community Health Centre...
June 13, 2024: Malaria Journal
https://read.qxmd.com/read/38867217/therapeutic-efficacy-and-safety-of-artemether-lumefantrine-for-uncomplicated-plasmodium-falciparum-malaria-treatment-in-metehara-central-east-ethiopia
#11
JOURNAL ARTICLE
Mahelet Tesfaye, Ashenafi Assefa, Henok Hailgiorgis, Bokretsion Gidey, Hussein Mohammed, Getachew Tollera, Geremew Tasew, Gudissa Assefa, Worku Bekele, Hassen Mamo
BACKGROUND: Malaria remains a major global health problem although there was a remarkable achievement between 2000 and 2015. Malaria drug resistance, along with several other factors, presents a significant challenge to malaria control and elimination efforts. Numerous countries in sub-Saharan Africa have documented the presence of confirmed or potential markers of partial resistance against artemisinin, the drug of choice for the treatment of uncomplicated Plasmodium falciparum malaria...
June 12, 2024: Malaria Journal
https://read.qxmd.com/read/38858779/community-readiness-and-acceptance-for-the-implementation-of-a-novel-malaria-vaccine-among-at-risk-children-in-sub-saharan-africa-a-systematic-review-protocol
#12
REVIEW
Eustes Kigongo, Amir Kabunga, Marc Sam Opollo, Raymond Tumwesigye, Marvin Musinguzi, Anne Ruth Akello, Jannat Nabaziwa, Temesgen Geta Hardido, Sean Steven Puleh
BACKGROUND: The World Health Organization novel malaria vaccine for at-risk children has the potential to greatly reduce the current malaria burden in sub-Saharan Africa. However, most studies have reported contradictory findings regarding community willingness for the vaccine, which could easily undermine the expected benefits of the vaccine. This study aims to ascertain the current state of community readiness and acceptance for the implementation of a novel malaria vaccine (RTS,S/ASO1) among at-risk children in sub-Saharan Africa, based on available evidence...
June 10, 2024: Malaria Journal
https://read.qxmd.com/read/38858778/drivers-of-autochthonous-malaria-cases-over-time-could-the-central-european-present-the-african-future
#13
JOURNAL ARTICLE
Zoltán Kenyeres
BACKGROUND: Results of spatial and temporal comparison of malaria hotspots and coldspots could improve the health measures of malaria control and eradication strategies. The study aimed to reveal the spatially and temporally independent correlations between the potentially most effective background variables and the number of autochthonous malaria cases. METHODS: Relationships between malaria cases and background variables were studied in 2 km × 2 km sized quadrates (10 Central European and 10 African)...
June 10, 2024: Malaria Journal
https://read.qxmd.com/read/38858696/chloroquine-has-shown-high-therapeutic-efficacy-against-uncomplicated-plasmodium-vivax-malaria-in-southern-ethiopia-seven-decades-after-its-introduction
#14
JOURNAL ARTICLE
Anteneh Kassahun Mare, Hussein Mohammed, Heven Sime, Henok Hailgiorgis, Kale Gubae, Bekuretsion Gidey, Mebrahtom Haile, Gudissa Assefa, Worku Bekele, Sarah Auburn, Rick Price, Jonathan B Parr, Jonathan J Juliano, Geremew Tasew, Solomon Mequanente Abay, Ashenafi Assefa
BACKGROUND: Plasmodium vivax malaria is a leading cause of morbidity in Ethiopia. The first-line treatment for P. vivax is chloroquine (CQ) and primaquine (PQ), but there have been local reports of CQ resistance. A clinical study was conducted to determine the efficacy of CQ for the treatment of P. vivax malaria in southern Ethiopia. METHODS: In 2021, patients with P. vivax mono-infection and uncomplicated malaria were enrolled and treated with 25 mg/kg CQ for 3 consecutive days...
June 10, 2024: Malaria Journal
https://read.qxmd.com/read/38844987/llin-evaluation-in-uganda-project-llineup-modelling-the-impact-of-covid-19-related-disruptions-on-delivery-of-long-lasting-insecticidal-nets-on-malaria-indicators-in-uganda
#15
JOURNAL ARTICLE
Jaffer Okiring, Samuel Gonahasa, Catherine Maiteki-Sebuguzi, Agaba Katureebe, Irene Bagala, Peter Mutungi, Simon P Kigozi, Jane F Namuganga, Joaniter I Nankabirwa, Moses R Kamya, Martin J Donnelly, Thomas S Churcher, Sarah G Staedke, Ellie Sherrard-Smith
BACKGROUND: Disruptions in malaria control due to COVID-19 mitigation measures were predicted to increase malaria morbidity and mortality in Africa substantially. In Uganda, long-lasting insecticidal nets (LLINs) are distributed nationwide every 3-4 years, but the 2020-2021 campaign was altered because of COVID-19 restrictions so that the timing of delivery of new nets was different from the original plans made by the National Malaria Control Programme. METHODS: A transmission dynamics modelling exercise was conducted to explore how the altered delivery of LLINs in 2020-2021 impacted malaria burden in Uganda...
June 6, 2024: Malaria Journal
https://read.qxmd.com/read/38844954/screening-blood-donors-for-malaria-can-we-increase-the-number-of-eligible-donors-an-observational-retrospective-study
#16
JOURNAL ARTICLE
María Dolores Corbacho-Loarte, Oihane Martín, Sandra Chamorro-Tojeiro, Clara Crespillo-Andújar, Francesca F Norman, José A Pérez-Molina, Marta González Sanz, Marta Rosas Cancio-Suárez, Gabriel Ruiz-Calvo, Alberto Richart López, José Miguel Rubio, Rogelio López-Vélez, Begoña Monge-Maillo
BACKGROUND: In non-endemic countries, malaria can be transmitted through blood donations from imported cases. To ensure standards of quality and safety of human blood, the European Union and Spanish national law, requires a deferral period, or a screening by immunological or genomic test among those donors with potential risk of malaria. Scientific societies, European Committee on Blood Transfusion, and Spanish Society of Haematology and Haemotherapy, refer only to the result of the immunological test...
June 6, 2024: Malaria Journal
https://read.qxmd.com/read/38840266/plasmodium-falciparum-neonatal-malaria-with-atypical-presentation-a-case-series-from-southwestern-ethiopia
#17
JOURNAL ARTICLE
Zerubabel Girma Tesso, Tariku Yigremachew Gossaye, Dereje Sileshi Bekana, Molla Asnake Kebede, Fikretsion Degemu Besir, Nikodimos Eshetu Dabe
BACKGROUND: Neonatal malaria is defined as the detection of asexual stages of Plasmodium species in the cord blood within the first 28 days of life. It can be congenital or acquired through mosquito bites or blood transfusions. Neonates are generally considered to be relatively protected due to the multiple innate and acquired physiological protective effects present in neonates. However, in areas where malaria is endemic, the prevalence of malaria in neonates is high. The predominant clinical feature of malaria in neonates is fever...
June 5, 2024: Malaria Journal
https://read.qxmd.com/read/38840196/insufficient-duration-of-insecticidal-efficacy-of-yahe-%C3%A2-insecticide-treated-nets-in-papua-new-guinea
#18
JOURNAL ARTICLE
Nakei Bubun, Evodia Anetul, Melanie Koinari, Petrina H Johnson, Leo S Makita, Timothy W Freeman, Leanne J Robinson, Moses Laman, Stephan Karl
BACKGROUND: Insecticide-treated nets (ITNs) are the backbone of anti-malarial vector control in Papua New Guinea (PNG). Over recent years the quality and performance of ITNs delivered to PNG decreased, which has likely contributed to the stagnation in the malaria control effort in the country. The present study reports results from the first 24 months of a durability study with the ITN product Yahe LN® in PNG. METHODS: The durability study was conducted in four villages on the northern coast of PNG, in an area with high malaria parasite transmission, following WHO-recommended methodology adapted to the local scenario...
June 5, 2024: Malaria Journal
https://read.qxmd.com/read/38840162/severe-malaria-intervention-status-in-nigeria-workshop-meeting-report
#19
JOURNAL ARTICLE
Emmanuel Shekarau, Miriam Uzoanya, Nnenna Ogbulafor
Nigeria accounts for 39% of global malaria deaths in children under 5 years of age and the effective management of severe malaria is a health priority. The Annual Nigeria Severe Malaria Stakeholders Workshop, held on the 5-6th of July 2023 in Abuja, Nigeria brought together representatives from 36 States, the Federal Capital Territory, and other key stakeholders to address the management of severe malaria across all levels of the health service. Aims were to provide updates and review progress on severe malaria activities, the burden of disease, commodity logistics management, and pre-referral national policy implementation as well as to disseminate research findings...
June 5, 2024: Malaria Journal
https://read.qxmd.com/read/38840151/bioequivalence-of-a-new-coated-15%C3%A2-mg-primaquine-formulation-for-malaria-elimination
#20
RANDOMIZED CONTROLLED TRIAL
Julie Nguyen Ngoc Pouplin, Thoopmanee Kaendiao, Bilal Ahmad Rahimi, Mayur Soni, Hensi Basopia, Darshana Shah, Jitendra Patil, Vyom Dholakia, Yash Suthar, Joel Tarning, Mavuto Mukaka, Walter R Taylor
BACKGROUND: With only one 15 mg primaquine tablet registered by a stringent regulatory authority and marketed, more quality-assured primaquine is needed to meet the demands of malaria elimination. METHODS: A classic, two sequence, crossover study, with a 10-day wash out period, of 15 mg of IPCA-produced test primaquine tablets and 15 mg of Sanofi reference primaquine tablets was conducted. Healthy volunteers, aged 18-45 years, without glucose-6-phosphate dehydrogenase deficiency, a baseline haemoglobin ≥ 11 g/dL, creatinine clearance ≥ 70 mL/min/1...
June 5, 2024: Malaria Journal
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