journal
https://read.qxmd.com/read/38204201/lupus-nephritis-and-socioeconomic-status-findings-from-the-southern-california-lupus-registry
#41
JOURNAL ARTICLE
Vaneet K Sandhu, Arezoo Haghshenas, Phildrich Teh, Emily He, Abigail Benitez, Lorena M Salto, Karina Torralba
OBJECTIVE: Lupus nephritis (LN) is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). Despite multiple studies addressing healthcare disparities, disparate outcomes in LN persist. We investigate herein the association between socioeconomic status (SES) and LN as well as the association between SES, SLE disease activity index (SLEDAI), and treatment response. METHODS: Patients were selected from the Southern California Lupus Registry (SCOLR), a registry enrolling all-comers with SLE...
January 10, 2024: Lupus
https://read.qxmd.com/read/38195200/analysis-of-5-year-hospitalization-data-of-patients-with-systemic-lupus-erythematosus-damage-is-a-risk-factor-for-frequent-and-longer-stays
#42
JOURNAL ARTICLE
Çiğdem Çetin, Melodi Gizem Can, Sinem Öztaşkın, Yasemin Yalçınkaya, Ahmet Gül, Murat İnanç, Bahar Artım Esen
OBJECTIVE: The annual hospitalization rate of patients with systemic lupus erythematosus (SLE) is approximately 10%, and hospitalizations are responsible for most of the healthcare expenses. Herein, we analyzed 5-year hospitalization data of SLE patients and determined factors leading to hospitalization. METHODS: Clinical, laboratory, and hospitalization data of SLE patients admitted to our rheumatology clinic in 2015-2020 were retrieved from our SLE database and analyzed...
January 9, 2024: Lupus
https://read.qxmd.com/read/38194931/systemic-lupus-erythematosus-is-associated-with-increased-risk-of-mortality-and-acute-kidney-injury-in-patients-with-covid-19-hospitalization-insights-from-a-national-inpatient-sample-analysis
#43
JOURNAL ARTICLE
Anum Akhlaq, Sameen Aamer, Khawaja Muthammir Hasan, Taimur Sohail Muzammil, Amir Humza Sohail, Mohammed A Quazi, Muhammad Salman Khan, Abu Baker Sheikh
INTRODUCTION: The COVID-19 pandemic has significantly impacted global health, especially for patients with chronic diseases that may compromise the immune system. This study investigates the association between systemic lupus erythematosus (SLE) and COVID-19 outcomes. METHODS: Data from the National Inpatient Sample (NIS) were analyzed to create a retrospective cohort of COVID-19 hospitalizations, comparing patients with and without SLE. Propensity-score matched analysis was conducted to assess the association between SLE and clinical outcomes in COVID-19 hospitalizations...
January 9, 2024: Lupus
https://read.qxmd.com/read/38194712/the-effect-of-respiratory-muscle-training-on-respiratory-muscle-strength-diaphragm-thickness-mobility-and-exercise-capacity-in-patients-with-systemic-lupus-erythematosus-and-associated-shrinking-lung-syndrome
#44
JOURNAL ARTICLE
Fulden Sari, Deran Oskay, Abdurrahman Tufan
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that can impact any organ in the body. The pathophysiology of shrinking lung syndrome (SLS), a rare pulmonary complication of SLE, remains unknown. The objective of the current case series was to investigate the effects of inspiratory muscle training (IMT) on diaphragm thickness/mobility, respiratory muscle strength, peripheral muscle thickness/strength, and functional exercise capacity in patients with SLE and associated SLS. Three patients with SLE were included in the case series...
January 9, 2024: Lupus
https://read.qxmd.com/read/38183242/clinical-algorithm-model-based-on-cfdna-to-predict-sle-disease-activity
#45
JOURNAL ARTICLE
Fang Wang, Yi-Jing Liu, Hai-Bing Miao, Zhen Chen
BACKGROUND: Circulating cell-free DNA (cfDNA) has been widely used as a new liquid-biopsy marker. Dysregulation of cfDNA has been found in patients with systemic lupus erythematosus (SLE). However, the detailed association between cfDNA and SLE has not been thoroughly studied. METHODS: Plasma samples were collected from 88 patients with active SLE and 39 patients with inactive SLE. The cfDNA concentration was determined, and the length and distribution of cfDNA fragments were verified...
January 6, 2024: Lupus
https://read.qxmd.com/read/38182135/right-ventricular-pulmonary-arterial-coupling-ratio-derived-from-3-dimensional-echocardiography-predicts-outcomes-in-systemic-lupus-erythematosus-associated-pulmonary-arterial-hypertension-patients
#46
JOURNAL ARTICLE
Wei-Fang Lan, Yan Deng, Ping Dai, Dan-Dan Wu, Jie Hu, Juan Liao, Hui Meng
BACKGROUND: Systemic lupus erythematosus (SLE) is a complex autoimmune connective tissue disease (CTD) that is an important cause of devastating pulmonary arterial hypertension (PAH), and persistent progression of PAH can lead to right heart failure, predicting a poor prognosis for SLE patients. Right ventricular-pulmonary arterial (RV-PA) coupling with echocardiography has been demonstrated to be a noninvasive alternative method for evaluating PAH patients' predictive outcomes. Whether the ratio of right ventricular stroke volume (RVSV) to right ventricular end-systolic volume (RVESV) measured by three-dimensional echocardiography (3DE) is a new index of RV-PA coupling has not been discussed as a new predictor for the clinical outcome of systemic lupus erythematosus-associated pulmonary arterial hypertension (SLE-PAH)...
January 5, 2024: Lupus
https://read.qxmd.com/read/38166465/integrating-spiritual-disposition-intervention-into-behavioral-medicine-a-case-report-on-systemic-lupus-erythematosus-from-india
#47
JOURNAL ARTICLE
Ishanpreet Kaur Toor, Kritika Rastogi, Sajal Ajmani
Background: Systemic Lupus Erythematosus (SLE) is a chronic inflammatory systemic autoimmune disease. The disease manifests as the body's immune cells start attacking healthy connective tissue, which affects the skin, kidneys, blood vessels, brain, and other vital organs. As with any other chronic illness, the disease has psychological implications. Purpose: Literature suggests patients with SLE experience anxiety, depression, anger, and stress along with physiological symptoms. There is a strong association between the occurrence of stress and the onset of the disease...
January 2, 2024: Lupus
https://read.qxmd.com/read/38164925/covid-vaccine-induced-lupus-nephritis-case-report-and-review-of-the-literature
#48
JOURNAL ARTICLE
Antonio Salas, Ayotola Fatola, Rebecca Krimins, Ihab R Kamel, Duvuru Geetha, Derek Fine, Manny Monroy-Trujillo, Avi Rosenberg, Lois Arend, Homa Timlin
Vaccines offer an effective strategy to prevent infectious diseases with minimal adverse effects. On rare occasions, vaccination can disrupt the immune response leading to induction of autoimmune diseases. We describe a case of new-onset lupus nephritis following COVID-19 vaccination with the first dose of the Pfizer vaccine. Her symptoms and lab values improved with steroids, hydroxychloroquine, and mycophenolate mofetil.
January 2, 2024: Lupus
https://read.qxmd.com/read/38164913/a-qualitative-study-of-facilitators-of-medication-adherence-in-systemic-lupus-erythematosus-perspectives-from-rheumatology-providers-staff-and-patients
#49
JOURNAL ARTICLE
Shannon Herndon, Amy Corneli, Carrie Dombeck, Teresa Swezey, Megan Eb Clowse, Jennifer L Rogers, Lisa G Criscione-Schreiber, Rebecca E Sadun, Jayanth Doss, Amanda M Eudy, Hayden B Bosworth, Kai Sun
OBJECTIVE: Systemic lupus erythematosus (SLE) disproportionately affects patients from racial and ethnic minority groups. Medication adherence is lower among these patient populations, and nonadherence is associated with worse health outcomes. We aimed to identify factors that enable adherence to immunosuppressive medications among patients with SLE from racial and ethnic minority groups. METHODS: Using a qualitative descriptive study design, we conducted in-depth interviews with purposefully selected (1) patients with SLE from racial and ethnic minority groups who were taking immunosuppressants and (2) lupus providers and staff...
January 2, 2024: Lupus
https://read.qxmd.com/read/38158842/the-clinicopathological-features-and-renal-prognostic-factors-in-pure-membranous-lupus-nephritis-a-large-series-cohort-study-from-china
#50
JOURNAL ARTICLE
Jing Hu, Mengyue Zhu, Jingjing Wang, Wenyuan Lou, Haitao Zhang
BACKGROUND: Membranous lupus nephritis (MLN) is a subepithelial immune deposition or its morphological sequelae with or without mesangial changes. Previous studies on the prognosis of MLN have shown relatively small sample sizes and short follow-up periods. METHODS: Our study was a retrospective analysis of biopsy-proven MLN patients from January 2010 to January 2020 at Jinling Hospital in China. The clinical manifestations, pathological features, and renal outcomes of MLN patients were collected...
December 30, 2023: Lupus
https://read.qxmd.com/read/38320572/reduced-mir-99a-3p-levels-in-systemic-lupus-erythematosus-may-promote-b-cell-proliferation-via-ncapg-and-the-pi3k-akt-signaling-pathway
#51
JOURNAL ARTICLE
Qing-Huan Zhu, Ya-Li Zhou, Meng Yang, Bin-Bin Yang, Wen-Ting Cao, Li-Mei Yuan, Dan-Qi Deng
BACKGROUND: Systemic lupus erythematosus is an immunologically dysregulated disease characterized by the presence of multiple autoantibodies. In SLE, B lymphocytes contribute to the dysregulated production of autoantibodies and cytokines. Recently, we discovered that miR-99a-3p binds to both EIF4EBP1 and NCAPG mRNA and that lowering miR-99a-3p can promote B cell autophagy in SLE by increasing EIF4EBP1 expression. However, the functions of miR-99a-3p and NCAPG in SLE have not been extensively investigated...
April 2024: Lupus
https://read.qxmd.com/read/38291414/t-cell-immunoglobulin-and-immunoreceptor-tyrosine-based-inhibitory-motif-domain-as-a-promising-immune-checkpoint-target-for-the-treatment-of-sle
#52
REVIEW
Junpeng Zhao, Liming Li, Xiwei Feng, Xinyu Fan, Huiqi Yin, Qianjin Lu
Immune checkpoints (ICs) play a pivotal role in orchestrating immune regulation, crucial for the maintenance of immune tolerance and prevention of autoimmune diseases. One noteworthy example among these immune regulators is T cell immunoglobulin (Ig) and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT). The TIGIT pathway's inhibition or the absence of TIGIT has been linked to the hyperactivation and excessive proliferation of T cells, rendering individuals more susceptible to autoimmune diseases and exacerbating inflammatory responses...
March 2024: Lupus
https://read.qxmd.com/read/38237938/a-12-month-follow-up-study-of-patients-with-systemic-lupus-erythematosus-after-immunization-against-sars-cov-2
#53
JOURNAL ARTICLE
Ernesto Zavala-Flores, Jannin Salcedo-Matienzo, Roberto Huamanchumo-Guzman, Alfredo Berrocal-Kasay, Graciela S Alarcón
OBJECTIVE: To identify all post-BNT162b2 vaccination (BioNTech and Pfizer) events during the ensuing 12 months in patients with systemic lupus erythematosus (SLE) from the Immuno-Rheumatology Department at Cayetano Heredia Hospital's cohort, Lima, Perú. METHODS: A 12-month follow-up study was conducted from the first dose of immunization with the BNT162b2 vaccine, which was given between May and June 2021, to SLE patients from this cohort. RESULTS: The initial population was constituted by 100 patients (100 patients received the 1st dose, 90 the 2nd dose, and 85 the 3rd dose of this vaccine); 33 patients presented a SLE reactivation (flare), 9% (9/100) post 1st dose, 26...
March 2024: Lupus
https://read.qxmd.com/read/38204378/effect-of-classroom-based-physical-activity-on-teaching-quality-of-systemic-lupus-erythematosus-for-medical-undergraduates
#54
JOURNAL ARTICLE
Yong Chen, Mang He, Shidan Tian, Yan Jiang, Yongqiao Zhang, Yupei Lin, Zhouxiong Xing, Kutty Selva Nandakumar, Mei Tian
OBJECTIVE: To explore the influence of classroom-based physical activity (CB-PA) on the teaching quality of systemic lupus erythematosus (SLE) for medical undergraduates. METHODS: Students from 8 classes participating in the clinical medicine program of the affiliated hospital of Zunyi Medical University were divided into two groups. Four classes received regular teaching on the SLE chapter as the control group, and the other four received CB-PA intervention as the experimental group...
March 2024: Lupus
https://read.qxmd.com/read/38320976/non-invasive-prediction-of-the-chronic-degree-of-lupus-nephropathy-based-on-ultrasound-radiomics
#55
RANDOMIZED CONTROLLED TRIAL
Chen Yin, Weihan Xiao, Xiaomin Hu, Xuebin Liu, Huaming Xian, Jun Su, Chaoxue Zhang, Xiachuan Qin
OBJECTIVE: Through machine learning (ML) analysis of the radiomics features of ultrasound extracted from patients with lupus nephritis (LN), this attempt was made to non-invasively predict the chronicity index (CI)of LN. METHODS: A retrospective collection of 136 patients with LN who had renal biopsy was retrospectively collected, and the patients were randomly divided into training set and validation set according to 7:3. Radiomics features are extracted from ultrasound images, independent factors are obtained by using LASSO dimensionality reduction, and then seven ML models were used to establish predictive models...
February 2024: Lupus
https://read.qxmd.com/read/38227433/complement-c4d-as-a-biomarker-for-systemic-lupus-erythematosus-and-lupus-nephritis
#56
REVIEW
Sihao Qin, Xueyao Wang, Jiahui Wang, Hao Wu
Background: Increasing studies in the last decade have led to the widespread understanding that C4d, a split product of complement component 4 (C4), is a potential biomarker for systemic lupus erythematosus (SLE) and lupus nephritis (LN). Purpose : The aim of this review is to summarize the highlights of studies investigating the use of C4d as a biomarker for diagnosing and monitoring SLE and LN patients. Data collection: we searched PubMed/Medline and Wanfang databases using the terms "C4d and systemic lupus erythematosus", "C4d and lupus nephritis", and "Complement C4d"...
February 2024: Lupus
https://read.qxmd.com/read/38158805/changes-in-retinal-and-choroidal-thickness-and-vascular-density-in-patients-with-systemic-lupus-erythematosus-assessed-by-optical-coherence-tomography-angiography
#57
JOURNAL ARTICLE
Jun Liu, Hui Zhang, Hua Yu, Ye Xia, Qiang Liu, Chao Geng, Lihong Dong, Yong Wang
OBJECTIVE: The aim was to investigate the changes in retinal and choroidal thickness and vascular density in patients with systemic lupus erythematosus (SLE) using optical coherence tomography angiography (OCTA). METHODS: Twenty-nine patients with SLE (29 eyes) and 25 control subjects (25 eyes) were enrolled. SLE activity was assessed using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Retinal thickness (RT), inner retinal thickness (IRT), outer retinal thickness (ORT), choroidal thickness (ChT), retinal superficial vascular density (SVD), retinal deep vascular density (DVD), choriocapillary vascular density (CCVD), foveal avascular zone (FAZ), superficial FAZ (sFAZ), and deep FAZ (dFAZ) were measured using OCTA...
February 2024: Lupus
https://read.qxmd.com/read/38113856/non-pharmacological-rehabilitation-interventions-for-individuals-with-antiphospholipid-syndrome-a-scoping-review
#58
REVIEW
Alexandra E Harper, Yen T Chen, Stephanie Tancer, Kyla R Rodgers, Amber D Crumb, Whitney A Townsend, Jason S Knight, Susan L Murphy
OBJECTIVE: The objective of this study was to explore what non-pharmacological interventions have been examined for individuals with antiphospholipid syndrome (APS). METHODS: We conducted a systematic literature search of the databases PubMed, Embase, Scopus, Web of Science, CINAHL, and ClinicalTrials.gov from 1983-Feb. 2023. Our scoping review included studies that examined non-pharmacological interventions for individuals with APS using patient-reported outcome measures...
February 2024: Lupus
https://read.qxmd.com/read/38116607/the-estimated-prevalence-of-antiphospholipid-antibodies-and-criteria-antiphospholipid-syndrome-in-subjects-with-renal-thrombotic-microangiopathy
#59
JOURNAL ARTICLE
Ofir Aluf, Silvia Parente, Massimo Radin, Loretta Campa, Valentina Gazzola, Akindamola Olugbogi, Nicolò Tesio, Heinrich Ugo, Edoardo Zanetti, Carla Zevallos, Elisabetta Versino, David Lembo, Dario Roccatello, Savino Sciascia
BACKGROUND: While the prevalence of antiphospholipid antibodies (aPL) in venous and arterial thrombotic events had already been estimated by previous studies, the prevalence of aPL in subjects with Thrombotic Microangiopathy (TMA) is still not fully elucidated. Thus, we conducted a systematic review to estimate the frequency of aPL in subjects with biopsy-proven renal TMA. METHODS: We conducted in the PubMed database a search for English-language studies investigating the presence of aPL in subjects with biopsy-proven renal TMA from January 1985 to December 2022...
January 2024: Lupus
https://read.qxmd.com/read/38069452/immunohistochemical-expression-of-perforin-in-adult-systemic-lupus-erythematosus-associated-macrophage-activation-syndrome-clinicohematological-correlation-and-literature-review
#60
REVIEW
Bakialakshmi Velayutham, Somanath Padhi, Sujata Devi, Susama Patra, Chinmayee Panigrahi, Mathan Kumar Ramasubbu, Rajesh Kumar, Samiur Raheman
OBJECTIVE: To study the bone marrow (BM) immunohistomorphological characteristics in adult systemic lupus erythematosus (SLE) associated macrophage activation syndrome (SLE-MAS). MATERIALS AND METHODS: Immunohistochemical (IHC) expression of CD3, CD8, perforin (PFN), and CD163 was studied on BM trephine biopsies from 30 cytopenic adult SLE cases (male: female = 1:5, age; 24 years, range; 19-32) and compared them with ten age matched controls. Clinicopathological parameters were compared among the cases likely (L) or unlikely (U) to have MAS using probability scoring criteria...
January 2024: Lupus
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