Stefan Vordenbäumen, Martin Kleefisch, Alexander Sokolowski, Christina Düsing, Jutta G Richter, Ralph Brinks, Matthias Schneider, Gamal Chehab
OBJECTIVE: To assess whether a healthy lifestyle is associated to beneficial effects on various systemic lupus erythematosus (SLE) health domains. METHODS: In a cross-sectional study, Mediterranean Diet Adherence Score (MEDAS), physical activity energy expenditure (PAEE), and smoking status were assessed by questionnaires, along with clinical parameters and various health domains including Systemic Lupus Disease Activity Score (SLEDAI), Depression Scale (CES-D), Fatigue Severity (FSS), functional status (FFbH), physical and mental quality of life (PCS, MCS)...
May 11, 2023: Lupus
Chun-Lung Wang, Malcolm Koo, Chia-Wen Hsu, Ming-Chi Lu
The objective of this cohort study was to evaluate the association between the frequency of hospital admissions and disease activity, as defined by two different disease activity measurements: the Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) and the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), in adult patients with systemic lupus erythematosus (SLEs). Patients with SLE were recruited from the rheumatology outpatient department of a regional hospital in southern Taiwan...
May 10, 2023: Lupus
Doaa Hs Attia, Abir Mokbel, Moataz Fatthy Mohamed, Hisham Mamdouh Haggag
Few studies tackled the long-term effect of pregnancy on lupus nephritis (LNs); thus, the study aimed to explore the long-term impact of pregnancy on renal outcomes in Egyptian patients with LN. Group I patients included females who had their first pregnancy after LN onset with ≥5 years elapsing after delivery; group II patients included females who had never got pregnant for ≥7 years after LN onset. Data were retrospectively collected at baseline (T0 ) and the last visit (Tlast ). The study included 43 patients in group I and 39 patients in group II...
May 10, 2023: Lupus
Paola León-Suárez, Iñigo Rúa-Figueroa, Jesús González Martín, Teresa Rodríguez-Sosa, Celia Erausquin, Cristina Del Pino Almeida Santiago, Francisco Rubiño Juárez, Yanira Pérez Vera, Laura Cáceres Martín, Rubén López Sánchez, Juan Carlos Quevedo Abeledo, Félix Francisco Hernández, Soledad Ojeda Bruno, Antonio Naranjo Hernández, Adrián Quevedo Rodríguez, Carlos Rodríguez Lozano
OBJECTIVES: To evaluate the prevalence of self-perceived depression and anxiety in patients with systemic lupus erythematosus (SLE) and to explore associated factors. METHODS: Cross-sectional study of unselected patients with SLE (ACR-97 criteria) and controls with chronic inflammatory rheumatic diseases. Both completed the Hospital Anxiety and Depression Scale (HADS). Demographic and clinical characteristics, comorbidity, and treatments were collected, and a multivariate analysis was performed to explore factors associated with depression and anxiety in SLE...
April 29, 2023: Lupus
Cecilia P Chung, Gul Karakoc, Alyson Dickson, Ge Liu, Jorge L Gamboa, Jonathan D Mosley, Nancy J Cox, Vivian K Kawai
BACKGROUND: Systemic lupus erythematosus (SLE) disproportionately affects individuals of African ancestry (AA) compared to European ancestry (EA). In the general population, high risk (HR) variants in the apolipoprotein L1 ( APOL1) gene increase the risk of renal and hypertensive disorders in individuals of AA. Since SLE is characterized by an interferon signature and APOL1 expression is driven by interferon, we examined the hypothesis that APOL1 HR genotypes predominantly drive higher rates of renal and hypertensive-related comorbidities observed in SLE patients of AA versus those of EA...
April 27, 2023: Lupus
Meghan Corrigan Nelson, Colleen Mosley, D Sofia Villacis-Nunez, Kelly Rouster-Stevens, Amit Thakral
BACKGROUND/PURPOSE: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, with a potential for significant disease damage, morbidity, and mortality. In comparison to the adult population, childhood-onset SLE (cSLE) tends to be more aggressive given the higher preponderance of renal and neuropsychiatric disease and increased disease activity. There is a paucity of literature examining relationship between disease activity, rheumatology follow-up visits, and health care utilization...
April 26, 2023: Lupus
Shilpa Arora, Joel A Block, Ailda Nika, Winston Sequeira, Patricia Katz, Meenakshi Jolly
PURPOSE: To assess if high quality of care (QOC) in SLE results in improved outcomes of quality of life (QOL) and non-routine health care utilization (HCU). METHODS: One hundred and forty consecutive SLE patients were recruited from the Rheumatology clinic at an academic center. Data on QOC and QOL were collected along with demographics, socio-economic, and disease characteristics at baseline. LupusPRO assessing health-related (HR) QOL and non (N)HRQOL was utilized...
April 25, 2023: Lupus
Ana P Sakamoto, Clovis A Silva, Ana C Pita, Vitor C Trindade, Aline G Islabao, Fernanda J Fiorot, Sandra Rm Lopes, Rosa Mr Pereira, Claudia Saad-Magalhaes, Gleice Cs Russo, Claudio A Len, Rogerio do Prado, Lucia Ma Campos, Nadia E Aikawa, Simone Appenzeller, Virginia Pl Ferriani, Marco F Silva, Marta Felix, Adriana R Fonseca, Ana Pl Assad, Flavio R Sztajnbok, Maria C Santos, Blanca E Bica, Evaldo G Sena, Ana J Moraes, Melissa M Fraga, Teresa C Robazzi, Paulo F Spelling, Iloite M Scheibel, Andre S Cavalcanti, Erica N Matos, Luciano J Guimaraes, Flavia P Santos, Licia Mh Mota, Eloisa Bonfa, Maria T Terreri
OBJECTIVES: To identify associations between mortality in cSLE patients and their characteristics: clinical and laboratory features, disease activity and damage scores, and treatment; to evaluate risk factors associated with mortality in cSLE; and to determine the most frequent causes of death in this group of patients. METHODS: We performed a multicenter retrospective cohort using data from 1,528 cSLE patients followed in 27 pediatric rheumatology tertiary centers in Brazil...
April 18, 2023: Lupus
Hakan Kisaoglu, Ozge Baba, Mukaddes Kalyoncu
OBJECTIVE: We aimed to compare the clinical and laboratory characteristics of patients with SLE according to the weighted complement status of the EULAR/ACR criteria and investigate whether different weighting of the complement status at disease onset is associated with outcomes. METHODS: Patients diagnosed with juvenile onset SLE who fulfilled the 2019 EULAR/ACR classification criteria were retrospectively analyzed. RESULTS: Among 43 patients included, hypocomplementemia was observed in 37 (86%), mostly with a low level of both complement C3 (C3) and complement C4 (C4) (53...
April 17, 2023: Lupus
Bei Jin, Cheng Cheng, Meizhen Tan, Jun Huang, Lizhi Chen, Zhilang Lin, Shuhan Zeng, Zihua Yu, Yingjie Li, Xiaoyun Jiang
BACKGROUND: Positive antineutrophil cytoplasmic antibody (ANCA) serology in adult-onset lupus nephritis (LN) is associated with more active disease and distinct renal pathology, but data with respect to childhood-onset LN remain scarce. Here, we aimed to determine the impact of positive ANCA serology on clinical and histopathologic features and renal outcomes in children with LN from multiple centers. METHODS: Clinical and histopathologic data of 61 ANCA-positive and 330 ANCA-negative LN children (1<age≤18 years) retrospectively enrolled from three pediatric nephrology centers were analyzed...
April 13, 2023: Lupus
Jia Wang, Hong-Xia Guo, Ting Cheng, Lei Shi, Sheng-Xiao Zhang, Xiao-Feng Li
BACKGROUND: Systemic lupus erythematosus (SLE) is a typical chronic immune disorder with clinical heterogeneity. The systemic abnormal immune response not only challenges the diagnosis and treatment of the disease itself but also the secondary antiphospholipid syndrome (APS), characterized by recurrent arterial or venous thrombosis, recurrent spontaneous abortion, or stillbirth. Clinical interest has primarily focused on primary APS's pathological and clinical features. However, differences in clinical features and laboratory indicators between SLE with or without APS are still lacking, especially differences between circulating lymphocytes, which are critical in the pathogenesis of SLE and its complications...
April 13, 2023: Lupus
Luis A González, Manuel F Ugarte-Gil, Guillermo J Pons-Estel, Graciela S Alarcón
Despite how difficult the early diagnosis of systemic lupus erythematosus (SLE) is, which is mainly due to the heterogeneity and non-specificity of its clinical manifestations, SLE is currently being diagnosed more frequently than in past decades. In fact, there has been an increase in the incidence and prevalence of SLE over the last four decades; this can be explained by a number of reasons including a better knowledge of the pathogenesis of the disease which allows its earlier diagnosis, the rising ethnic and racial diversity of the world population, the use of the 2019 EULAR/ACR criteria that allows classifying patients earlier, and improvements in survival over the last decades, which results in an increase in the prevalent cases of SLE...
April 11, 2023: Lupus
M L Barraclough, J P Diaz-Martinez, A Knight, K Bingham, J Su, M Kakvan, C Muñoz Grajales, M C Tartaglia, L Ruttan, J Wither, M Y Choi, D Bonilla, N Anderson, S Appenzeller, B Parker, P Katz, D Beaton, R Green, I N Bruce, Z Touma
OBJECTIVE: During the COVID-19 pandemic, many research studies were adapted, including our longitudinal study examining cognitive impairment (CI) in systemic lupus erythematosus (SLE). Cognitive testing was switched from in-person to virtual. This analysis aimed to determine if the administration method (in-person vs. virtual) of the ACR-neuropsychological battery (ACR-NB) affected participant cognitive performance and classification. METHODS: Data from our multi-visit, SLE CI study included demographic, clinical, and psychiatric characteristics, and the modified ACR-NB...
April 10, 2023: Lupus
Nikolaos Koletsos, Konstantina Dipla, Areti Triantafyllou, Panagiotis Dolgyras, Spyros Aslanidis, Andreas Zafeiridis, Vasiliki Galanopoulou, Stella Douma, Eugenia Gkaliagkousi
OBJECTIVES: Depression is highly prevalent among systemic lupus erythematosus (SLE) patients. Brain hypoperfusion in neuropsychiatric SLE patients might be associated with emotional difficulties. However, no previous study examined possible associations of depression with brain oxygenation during a mild physical stress in non-neuropsychiatric SLE patients. Our study aimed to identify possible differences in cerebral oxygenation during exercise in SLE patients with and without depressive symptoms using near-infrared spectroscopy (NIRS) and examine possible underlying mechanisms through evaluation of vascular cell adhesion molecule 1 (VCAM-1) levels...
March 29, 2023: Lupus
Yulia Tunitsky-Lifshitz, Ramit Maoz-Segal, Stanley Niznik, Ronen Shavit, Soad Haj Yahia, Pnina Langevitz, Nancy Agmon-Levin
INTRODUCTION: Over 95% of healthy subjects develop anti-COVID IgG antibodies after receiving two doses of BNT162b2 COVID-19 vaccine. In comparison, 20%-30% of SLE patients do not seroconvert following 1-2 doses of COVID vaccines, potentially due to immunosuppression. The aim of this study was to assess immunogenicity and safety of BNT vaccine in SLE patients treated with Belimumab and especially the yield of a booster third dose in this population. METHODS: SLE patients treated with Belimumab in the Sheba Medical Center, Israel, were included in this study...
March 23, 2023: Lupus
Edward Itelman, Maxim Perelman, Natali Bivar, Daniella Kent, Adva Vaisman, Gad Segal, Liat Negru, Amir Dagan
PURPOSE: To investigate whether low complement levels can predict worse outcomes in patients hospitalized with positive anti-phospholipid antibodies. METHODS: This was a retrospective cohort study. We obtained demographics, laboratory, and prognostic data of all consecutive patients hospitalized between 2007 and 2021, for whatever reason, with at least one positively abnormal anti-phospholipid antibody, who were also tested for complement levels (C3 or C4). We then compared the rates of long-term mortality, 1-year mortality, deep vein thrombosis, and pulmonary emboli between groups of low complement and normal complement levels...
March 23, 2023: Lupus
Sameh Bougatf, Faida Ajili, Sameh Sayhi
Since the improvement in management and the reduction of mortality caused by the disease activity, infections have represented the main cause of morbidity and mortality in systemic lupus erythematosus patients. We aimed to determine the prevalence and identify risk factors of severe infections in systemic lupus erythematosus patients. We conducted a retrospective study on 93 Tunisian lupus patients followed between 2010 and 2019. The mean age of the disease was 33.63 ± 13.76 years. Fifty-two patients had 118 infections and 16% of the infections were serious...
March 21, 2023: Lupus
Mallet R Reid, Ashley N Danguecan, Isabella Colindres, Denasja Witherspoon, Tamar B Rubinstein, Cristina Drenkard, Andrea M Knight, Natoshia R Cunningham
Systemic Lupus Erythematosus (SLE) is a complex chronic autoimmune disease disproportionally afflicting women and, in particular, American Indian/Alaska Native, Black, and Hispanic women. These groups of women have significantly worse SLE-related health outcomes which are partially attributable to their exposure to marginalizing and interconnecting social issues like racism, sexism, economic inequality, and more. Although these groups of women have higher rates of SLE and though it is well known that they are at risk of exposure to marginalizing social phenomena, relatively little SLE literature explicitly links and addresses the relationship between marginalizing social issues and poor SLE-health outcomes among these women...
March 15, 2023: Lupus
Zhilang Lin, Nannan Yu, Cheng Cheng, Bei Jin, Qiufang Zhang, Hongjie Zhuang, Xiaoyun Jiang
OBJECTIVE: The aim of this study was to investigate serum levels of soluble B-cell maturation antigen (sBCMA) in childhood-onset systemic lupus erythematous (cSLE) patients with renal involvement, and to elucidate their association with clinical characteristics. METHODS: 116 cases of cSLE patients with renal involvement (84 females and 32 males; median age 11.6 (10.1, 12.9) years) hospitalized in Department of Pediatric Nephrology and Rheumatology, the First Affiliated Hospital, Sun Yat-sen University and 31 healthy controls (HCs) were enrolled...
March 13, 2023: Lupus
Anjali S Yennemadi, Joseph Keane, Gina Leisching
The association of dysregulated metabolism in systemic lupus erythematosus (SLE) pathogenesis has prompted investigations into metabolic rewiring and the involvement of mitochondrial metabolism as a driver of disease through NLRP3 inflammasome activation, disruption of mitochondrial DNA maintenance, and pro-inflammatory cytokine release. The use of Agilent Seahorse Technology to gain functional in situ metabolic insights of selected cell types from SLE patients has identified key parameters that are dysregulated during disease...
March 13, 2023: Lupus
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