journal
https://read.qxmd.com/read/38607271/idiopathic-intracranial-hypertension-as-the-initial-presenting-manifestation-of-systemic-lupus-erythematosus-in-a-child
#1
JOURNAL ARTICLE
Murugan Sudhakar, Anu P Kocheril, Anish S George, George I Vettiyil, Anitha Jasper, Sathish Kumar
Idiopathic intracranial hypertension (IIH) is a diagnosis of exclusion characterized by features of raised intracranial pressure (ICP) in the absence of brain parenchymal lesion, vascular malformations, hydrocephalus, or central nervous system (CNS) infection. Commonly used other terms for this entity include benign intracranial hypertension (BIH) or pseudotumor cerebri. Few case reports of systemic lupus erythematosus (SLE) presenting as IIH are available in the literature. We report a 12-year-old girl presented with chronic holocranial headache and occasional episodes of projectile vomiting for the last 6 months and then developed blurring of vision for the last month...
April 12, 2024: Lupus
https://read.qxmd.com/read/38594808/considering-belimumab-during-pregnancy-a-more-viable-option-over-time
#2
JOURNAL ARTICLE
Paloma Vela-Casasempere, Rocío Caño Alameda, Silvia Gómez Sabater, Silvia Cortell Aznar, Encarnación Pérez Pascual
OBJECTIVE: To share our experience with belimumab in lupus pregnant women and to review the relevant published literature on its use in this scenario. METHODS: A prospective observational study of pregnant patients with lupus was conducted. Additionally, MEDLINE and EMBASE databases were searched, and a secondary hand search of the literature was performed. Studies were evaluated and visualised descriptively. RESULTS: Sixteen pregnancies of 12 lupus women were included, six (involving eight pregnancies) received belimumab throughout their illness, five of them during some period of gestation...
April 9, 2024: Lupus
https://read.qxmd.com/read/38594605/maternal-and-fetal-outcomes-in-pregnancy-complicated-by-pre-existing-lupus-nephritis-insights-from-a-developing-country-pakistan
#3
JOURNAL ARTICLE
Tabassum Elahi, Saima Ahmed, Muhammed Mubarak, Ejaz Ahmed
BACKGROUND: Pregnancy in women with systemic lupus erythematosus (SLE) has remained a great challenge for clinicians in terms of maternal and fetal outcomes. The outcomes in women with pre-existing lupus nephritis (LN) are variable. The impact of different classes of LN on maternal and fetal outcomes during pregnancy is not well defined, as data is very scarce, especially from the developing countries. METHODS: A retrospective analysis was conducted on 52 women with 89 pregnancies...
April 9, 2024: Lupus
https://read.qxmd.com/read/38587355/enrolment-of-the-first-paediatric-cohort-into-the-australian-lupus-registry-and-biobank-a-single-centre-experience
#4
JOURNAL ARTICLE
Bronwyn D Power, Rangi Kandane-Rathnayake, Georgina Tiller, William D Renton, Angela Cox, Lilian Johnstone, Alberta Hoi, Peter Gowdie
INTRODUCTION: We aim to report on the feasibility of establishment of the first paediatric cohort as part of the longitudinal database of the Australian Lupus Registry and Biobank (ALRB) and to describe the enrolment data with a focus on clinical characteristics, serological data, treatment strategies and patient/parent-reported outcome measures. METHODS: All patients under the age of 18 years with a diagnosis of systemic lupus erythematosus (SLE) attending the paediatric rheumatology service of a single, tertiary hospital were identified...
April 8, 2024: Lupus
https://read.qxmd.com/read/38580326/drug-induced-lupus-erythematosus-in-childhood-case-based-review
#5
JOURNAL ARTICLE
Ummusen Kaya Akca, Seher Sener, Ezgi Deniz Batu, Zeynep Balik, Ozge Basaran, Yelda Bilginer, Seza Ozen
BACKGROUND: Drug-induced lupus erythematosus (DILE) is the development of lupus-like syndrome following a drug exposure. DILE has been reported less frequently among children than adults. METHODS: In this study, we present four children with DILE and similar published cases through a systematic literature review. RESULTS: We report four children (three girls and one boy) who developed DILE associated with the use of topiramate, doxycycline, etanercept, and ethosuximide...
April 5, 2024: Lupus
https://read.qxmd.com/read/38577967/lack-of-awareness-of-systemic-lupus-erythematosus-and-its-consequences-in-a-cohort-of-moderate-and-severe-patients-in-spain-the-lupusvoice-study
#6
JOURNAL ARTICLE
Maria Galindo Izquierdo, Joaquín Borrás Blasco, Silvia Pérez Ortega, Tarek Carlos Salman-Monte, Paloma Vela-Casasempere, Esther Rodríguez Almaraz, Jaime Calvo-Alen, José María Álvaro-Gracia Álvaro, M Julia Barbado Ajo, Raül Rubio Renau, Marta Galvez-Fernandez, Noemí Bahamontes-Rosa, Joaquín Sánchez-Covisa Hernández, Carlota Solà Marsiñach
BACKGROUND AND OBJECTIVES: Systemic lupus erythematosus (SLE) is an autoimmune condition that can highly impact patients' quality of life (QoL). However, there is a lack of knowledge about SLE, affecting the general population and health care professionals (HCPs) alike. This lack of knowledge has negative implications for patients and the healthcare system, worsening prognosis, negatively impacting QoL, and increasing healthcare utilization. The aim of this paper is to draw attention, according to the perspective of the participants of this study, to the lack of awareness of SLE and its consequences in Spain, and to suggest improvements...
April 5, 2024: Lupus
https://read.qxmd.com/read/38571373/home-monitoring-of-fetal-heart-rhythm-lived-experiences-of-women-with-anti-ssa-ro52-autoantibodies-and-their-co-parents
#7
JOURNAL ARTICLE
Joanna Tingström, Elin Öst, Gunnar Bergman, Åsa Burström
OBJECTIVE: The aim of this study was to explore the parents' experiences of home monitoring of the fetal heart rhythm. Women with anti-SSA/Ro52 autoantibodies carry a 2%-3% risk of giving birth to a child with congenital heart block (CHB), following transplacental transfer and antibody-mediated inflammation in the fetal conduction system during 18th to 24th gestational week. Early detection and subsequent treatment have been reported to decrease morbidity and mortality. Therefore, home monitoring of the fetal heart rhythm by Doppler has been offered at our fetal cardiology center...
April 3, 2024: Lupus
https://read.qxmd.com/read/38569663/membranous-lupus-nephritis-secondary-to-secukinumab-therapy-a-case-report-and-literature-review
#8
JOURNAL ARTICLE
Yi Zhou, Zhangxue Hu
The interleukin (IL)-17 axis is involved in many inflammatory and autoimmune diseases. Secukinumab, an IL-17 inhibitor, has been approved for psoriasis treatment. There are accumulating cases of lupus erythematosus induced by IL-17 inhibition. Lupus nephritis after IL-17 inhibition has not been reported. We report the case of a 57-year-old man who developed membranous lupus nephritis after secukinumab treatment for psoriasis. Anti-SSA and PM-Scl antibodies were positive. dsDNA, anti-Smith, and anti-histone antibodies were negative, and serum complement was low...
April 3, 2024: Lupus
https://read.qxmd.com/read/38569651/results-and-prognosis-of-kidney-transplantation-in-lupus-nephritis-experience-of-an-argentine-center
#9
JOURNAL ARTICLE
Sofía Ornella, Lucila García, Máximo Cosentino, Marcelo F Taylor, Martín Ciappa, Mercedes A García
INTRODUCTION: Although RT has improved the survival of the population with ESRD due to all causes, renal outcomes in SLE are controversial. The objective of this study is to describe the characteristics and evolution of the patients and the kidney transplant in LN, and compare it with patients transplanted for other causes. MATERIALS AND METHODS: Retrospective, observational, analytical, single-center study in which records of patients undergoing nephrotransplantation for LN were analyzed...
April 3, 2024: Lupus
https://read.qxmd.com/read/38564733/the-impact-of-libman-sacks-endocarditis-on-inpatient-outcomes-with-systemic-lupus-erythematosus-a-retrospective-study
#10
JOURNAL ARTICLE
Halah Alfatlawi, Abdulmajeed Alharbi, Momin Shah, Yusuf Nawras, Nezam Altorok
INTRODUCTION: The existing literature offers limited insights into the influence of Libman-Sacks Endocarditis (LSE) on inpatient outcomes in individuals with Systemic Lupus Erythematosus (SLE). This study aimed to explore the characteristics and prognosis of SLE patients with LSE and the impact of LSE in patients with SLE on inpatient outcomes including inpatient mortality, length of stay, acute heart failure, atrial fibrillation, and cerebrovascular accidents (CVA). METHODS: This study included adult patients who were hospitalized with SLE between the years 2019 and 2020, using the National Inpatient Sample (NIS) database...
April 2, 2024: Lupus
https://read.qxmd.com/read/38545763/factors-associated-with-non-adherence-to-medications-in-systemic-lupus-erythematosus-results-from-a-swedish-survey
#11
JOURNAL ARTICLE
Sharzad Emamikia, Alvaro Gomez, Theodor Ådahl, Gunilla von Perner, Yvonne Enman, Katerina Chatzidionysiou, Elizabeth V Arkema, Ioannis Parodis
OBJECTIVE: To identify determinants of medication non-adherence in a Swedish population of systemic lupus erythematosus (SLE). METHODS: Patients with SLE from Karolinska and Örebro University Hospitals participated in a survey-based cross-sectional study. Demographics, disease activity, organ damage, HRQoL (LupusQol, EQ-5D-5 L), medication non-adherence (<80% on CQR-19 or MASRI) and beliefs about medicines (BMQ) were registered. MASRI was used to report adherence to different drugs/drug classes, categorised into (i) antimalarial agents (AMA), (ii) glucocorticoids and (iii) other SLE medications...
March 28, 2024: Lupus
https://read.qxmd.com/read/38533912/comparison-of-systemic-lupus-international-collaborating-clinics-2012-classification-criteria-and-european-league-against-rheumatism-american-college-of-rheumatology-2019-classification-criteria-for-early-detection-of-childhood-onset-systemic-lupus-erythematosus
#12
JOURNAL ARTICLE
Esraa Babgi, Munira Al Marri, Sulaiman M Al-Mayouf, Rawia Shehata, Mahmoud Majeed, Khayriah Alsufyani, Entesar Batouk, Reema Bakri, Ashwaq AlE'ed, Mada Yateem, Lujayn Akbar, Shahad Gari, Wafa Alghamdi, Abdularahman Asiri, Abdulaziz Al Rowais
OBJECTIVE: To assess the performance of the new EULAR/ACR criteria, particularly for early detection of cSLE, in comparison to the SLICC criteria among the pediatric population in multiple centers in Saudi Arabia. METHODS: We conducted a retrospective study that enrolled pediatric patients up to the age of 14 years who've been diagnosed with SLE and followed in pediatric rheumatology clinics at 9 multi-tertiary hospitals in Saudi Arabia from 2010 to 2021 as a case group and were compared to a similar group of pediatric patients who've had defined rheumatological diseases other than SLE with a positive ANA titer (≥1:80) as controls...
March 27, 2024: Lupus
https://read.qxmd.com/read/38518059/the-use-of-belimumab-on-patients-with-both-systemic-lupus-erythematosus-and-immune-thrombocytopenia-a-retrospective-cohort-study
#13
JOURNAL ARTICLE
Qi Wu, Ming-Xue Zhao, Xiao-Shan Huang, Chang-Song Lin, Qiang Xu
OBJECTIVE: The objective of this study is to provide a description of a group of retrospective cohort outcomes in patients with systemic lupus erythematosus (SLE) complicated with immune thrombocytopenia (ITP) receiving belimumab. METHODS: This study reports on the treatment of 10 female patients (mean age 34.3 ± 14.0 years, mean weight 58.7 ± 18.2 kg) with both SLE and ITP who received belimumab in addition to basic drug therapy. The belimumab treatment regimen consisted of a dosage of 10 mg/kg, with an initial infusion every 2 weeks for the first 3 doses, followed by an infusion every 4 weeks...
March 22, 2024: Lupus
https://read.qxmd.com/read/38514381/epidemiological-immunological-and-treatment-response-profile-of-patients-with-lupus-nephritis-in-brazil
#14
JOURNAL ARTICLE
Mariana Sousa Teixeira Nunes, Lectícia Barbosa Jorge, Luis Yu, Viktoria Woronik, Cristiane Bitencourt Dias
BACKGROUND AND HYPOTHESIS: Brazil has the largest number of individuals of African descent outside Africa and a very admixed population. Among cases of lupus nephritis (LN) in the country, there are differences in incidence, and even in severity, depending on the location and characteristics of the population studied. The aim of this study was to describe the clinical and epidemiological characteristics of LN in Brazil, as well as to determine which of those characteristics would be risk factors for a poor renal prognosis...
March 21, 2024: Lupus
https://read.qxmd.com/read/38511579/significant-heightened-methylation-levels-of-runx3-gene-promoter-in-patients-with-systemic-lupus-erythematosus
#15
JOURNAL ARTICLE
Naeim Ehtesham, Samira Alesaeidi, Dorita Mohammad Zadeh, Mozhdeh Saghaei, Maryam Fakhri, Zahra Bayati, Emran Esmaeilzadeh, Meysam Mosallaei
OBJECTIVE: Researchers are actively investigating new diagnostic and prognostic biomarkers that offer improved sensitivity and specificity for systemic lupus erythematosus (SLE). One area of interest is DNA methylation changes. Previous studies have shown a connection between the RUNX3 gene dysfunction and SLE. In this study, the focus was on examining the methylation level of the RUNX3 promoter in peripheral blood mononuclear cells (PBMCs) of SLE patients and healthy individuals. METHODS: A total of 80 individuals diagnosed with SLE from Iran, along with 77 healthy individuals, were included...
March 21, 2024: Lupus
https://read.qxmd.com/read/38509864/initiation-of-belimumab-with-higher-daily-prednisolone-is-effective-for-rapid-glucocorticoid-reduction-a-96-week-retrospective-study
#16
JOURNAL ARTICLE
Takashi Yamane, Akira Hashiramoto
OBJECTIVES: For appropriate glucocorticoid (GC) reduction, we investigated the optimal strategy including baseline factors that could reduce GC more than 50% with 96 weeks of belimumab. METHODS: This is a retrospective cohort study of Kakogawa Central City hospital from 2019 to 2023. We identified SLE patients who were receiving 200 mg of belimumab weekly by subcutaneous injection for 96 weeks. The background at baseline, trends in clinical indicators, and factors involved in GC reduction were statistically analyzed...
March 21, 2024: Lupus
https://read.qxmd.com/read/38506324/aberrant-phenotypes-of-circulating-%C3%AE-%C3%AE-t-cells-may-be-involved-in-the-onset-of-systemic-lupus-erythematosus
#17
JOURNAL ARTICLE
Shiwen Yuan, Cuicui Wang, Yanting Zeng, Jiawei Li, Weinian Li, Zhixiang He, Jinghua Ye, Fangfei Li, Yi Chen, Xiaojun Lin, Yan Xu, Na Yu, Xiaoyan Cai
OBJECTIVE: Human gamma-delta T cells (γδ-T cells) play crucial roles in both innate and adaptive immune responses. However, much less is known about the immune status of γδT cells in systemic lupus erythematosus (SLE) patients. The objective of this study was to explore potential relationships between the frequency of γδ-T-cell subpopulations and disease activity, autoantibody titres and renal involvement in patients with SLE. METHODS: Circulating γδ-T cells and their subsets (Vδ1+ T cells, Vδ2+ T cells and γδ-T-cell subpopulations defined by expression of surface receptors, including NKG2D, NKp30, NKp46 and PD-1), were identified via flow cytometry...
March 20, 2024: Lupus
https://read.qxmd.com/read/38506239/anca-in-patients-with-systemic-lupus-erythematosus-a-cross-sectional-study-in-brazilian-patients-and-review-of-literature
#18
JOURNAL ARTICLE
Renato Nisihara, Gabriela Vithoft, Isabela Alencar, Thiago Alberto F G Dos Santos, Thelma Larocca Skare
BACKGROUND: Antineutrophil cytoplasmatic antibodies (ANCA) have been detected in patients with systemic lupus erythematosus (SLE). In this study, we investigated the presence of ANCA in a sample of Brazilian SLE patients and its possible associations with clinical and serological outcomes. Additionally, we reviewed the literature of on ANCA in SLE. RESULTS: The presence of ANCA was detected in 130 patients using indirect immunofluorescence (IIF). The test was positive in 29...
March 20, 2024: Lupus
https://read.qxmd.com/read/38491423/subclinical-synovitis-impact-on-the-progression-of-lupus-joint-disease-a-10-year-longitudinal-multicenter-study
#19
JOURNAL ARTICLE
Carlos A Guillén-Astete, Marcelino Revenga-Martínez, Antonio C Zea-Mendoza, María E Brito-Brito, Pablo Zurita-Prada, Claudia Urrego-Laurín, Lourdes Villalobos-Sánchez, Nuria García-Montes, Mónica Vázquez-Díaz
OBJECTIVE: To determine the effect of subclinical synovitis on the progression of joint disease in a cohort of patients with systemic lupus erythematosus over a mean follow-up of 10 years. METHODS: A longitudinal follow-up of 96 patients diagnosed with lupus was performed. All patients were considered clinically free of joint disease or with minimal joint impairment at baseline and were studied through ultrasound study of their dominant hand to assess the prevalence of subclinical synovitis...
March 15, 2024: Lupus
https://read.qxmd.com/read/38490946/global-tuberculosis-disease-and-infection-in-systemic-lupus-erythematosus-patients-a-systematic-review-and-meta-analysis
#20
JOURNAL ARTICLE
Guntur Darmawan, Lie Monica Sherine Liman, Suryo Anggoro Kusumo Wibowo, Laniyati Hamijoyo, Lika Apriani, Nur Atik, Bachti Alisjahbana, Edhyana Sahiratmadja
BACKGROUND: Tuberculosis (TB) is one of the most common infections among systemic lupus erythematosus (SLE) patients. We aimed to evaluate the global prevalence of TB infection and disease, its type, and medication risk factors in SLE patients. METHODS: We searched PubMed, Science Direct, EBSCO, and Web of Science databases from inception to April 30, 2023, and included studies assessing TB among SLE patients. We estimated the prevalence of TB disease (including type of TB disease), TB infection, and SLE medication as TB risk factors...
March 15, 2024: Lupus
journal
journal
20193
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.