journal
https://read.qxmd.com/read/38533912/comparison-of-systemic-lupus-international-collaborating-clinics-2012-classification-criteria-and-european-league-against-rheumatism-american-college-of-rheumatology-2019-classification-criteria-for-early-detection-of-childhood-onset-systemic-lupus-erythematosus
#1
JOURNAL ARTICLE
Esraa Babgi, Munira Al Marri, Sulaiman M Al-Mayouf, Rawia Shehata, Mahmoud Majeed, Khayriah Alsufyani, Entesar Batouk, Reema Bakri, Ashwaq AlE'ed, Mada Yateem, Lujayn Akbar, Shahad Gari, Wafa Alghamdi, Abdularahman Asiri, Abdulaziz Al Rowais
OBJECTIVE: To assess the performance of the new EULAR/ACR criteria, particularly for early detection of cSLE, in comparison to the SLICC criteria among the pediatric population in multiple centers in Saudi Arabia. METHODS: We conducted a retrospective study that enrolled pediatric patients up to the age of 14 years who've been diagnosed with SLE and followed in pediatric rheumatology clinics at 9 multi-tertiary hospitals in Saudi Arabia from 2010 to 2021 as a case group and were compared to a similar group of pediatric patients who've had defined rheumatological diseases other than SLE with a positive ANA titer (≥1:80) as controls...
March 27, 2024: Lupus
https://read.qxmd.com/read/38518059/the-use-of-belimumab-on-patients-with-both-systemic-lupus-erythematosus-and-immune-thrombocytopenia-a-retrospective-cohort-study
#2
JOURNAL ARTICLE
Qi Wu, Ming-Xue Zhao, Xiao-Shan Huang, Chang-Song Lin, Qiang Xu
OBJECTIVE: The objective of this study is to provide a description of a group of retrospective cohort outcomes in patients with systemic lupus erythematosus (SLE) complicated with immune thrombocytopenia (ITP) receiving belimumab. METHODS: This study reports on the treatment of 10 female patients (mean age 34.3 ± 14.0 years, mean weight 58.7 ± 18.2 kg) with both SLE and ITP who received belimumab in addition to basic drug therapy. The belimumab treatment regimen consisted of a dosage of 10 mg/kg, with an initial infusion every 2 weeks for the first 3 doses, followed by an infusion every 4 weeks...
March 22, 2024: Lupus
https://read.qxmd.com/read/38514381/epidemiological-immunological-and-treatment-response-profile-of-patients-with-lupus-nephritis-in-brazil
#3
JOURNAL ARTICLE
Mariana Sousa Teixeira Nunes, Lectícia Barbosa Jorge, Luis Yu, Viktoria Woronik, Cristiane Bitencourt Dias
BACKGROUND AND HYPOTHESIS: Brazil has the largest number of individuals of African descent outside Africa and a very admixed population. Among cases of lupus nephritis (LN) in the country, there are differences in incidence, and even in severity, depending on the location and characteristics of the population studied. The aim of this study was to describe the clinical and epidemiological characteristics of LN in Brazil, as well as to determine which of those characteristics would be risk factors for a poor renal prognosis...
March 21, 2024: Lupus
https://read.qxmd.com/read/38511579/significant-heightened-methylation-levels-of-runx3-gene-promoter-in-patients-with-systemic-lupus-erythematosus
#4
JOURNAL ARTICLE
Naeim Ehtesham, Samira Alesaeidi, Dorita Mohammad Zadeh, Mozhdeh Saghaei, Maryam Fakhri, Zahra Bayati, Emran Esmaeilzadeh, Meysam Mosallaei
OBJECTIVE: Researchers are actively investigating new diagnostic and prognostic biomarkers that offer improved sensitivity and specificity for systemic lupus erythematosus (SLE). One area of interest is DNA methylation changes. Previous studies have shown a connection between the RUNX3 gene dysfunction and SLE. In this study, the focus was on examining the methylation level of the RUNX3 promoter in peripheral blood mononuclear cells (PBMCs) of SLE patients and healthy individuals. METHODS: A total of 80 individuals diagnosed with SLE from Iran, along with 77 healthy individuals, were included...
March 21, 2024: Lupus
https://read.qxmd.com/read/38509864/initiation-of-belimumab-with-higher-daily-prednisolone-is-effective-for-rapid-glucocorticoid-reduction-a-96-week-retrospective-study
#5
JOURNAL ARTICLE
Takashi Yamane, Akira Hashiramoto
OBJECTIVES: For appropriate glucocorticoid (GC) reduction, we investigated the optimal strategy including baseline factors that could reduce GC more than 50% with 96 weeks of belimumab. METHODS: This is a retrospective cohort study of Kakogawa Central City hospital from 2019 to 2023. We identified SLE patients who were receiving 200 mg of belimumab weekly by subcutaneous injection for 96 weeks. The background at baseline, trends in clinical indicators, and factors involved in GC reduction were statistically analyzed...
March 21, 2024: Lupus
https://read.qxmd.com/read/38506324/aberrant-phenotypes-of-circulating-%C3%AE-%C3%AE-t-cells-may-be-involved-in-the-onset-of-systemic-lupus-erythematosus
#6
JOURNAL ARTICLE
Shiwen Yuan, Cuicui Wang, Yanting Zeng, Jiawei Li, Weinian Li, Zhixiang He, Jinghua Ye, Fangfei Li, Yi Chen, Xiaojun Lin, Yan Xu, Na Yu, Xiaoyan Cai
OBJECTIVE: Human gamma-delta T cells (γδ-T cells) play crucial roles in both innate and adaptive immune responses. However, much less is known about the immune status of γδT cells in systemic lupus erythematosus (SLE) patients. The objective of this study was to explore potential relationships between the frequency of γδ-T-cell subpopulations and disease activity, autoantibody titres and renal involvement in patients with SLE. METHODS: Circulating γδ-T cells and their subsets (Vδ1+ T cells, Vδ2+ T cells and γδ-T-cell subpopulations defined by expression of surface receptors, including NKG2D, NKp30, NKp46 and PD-1), were identified via flow cytometry...
March 20, 2024: Lupus
https://read.qxmd.com/read/38506239/anca-in-patients-with-systemic-lupus-erythematosus-a-cross-sectional-study-in-brazilian-patients-and-review-of-literature
#7
JOURNAL ARTICLE
Renato Nisihara, Gabriela Vithoft, Isabela Alencar, Thiago Alberto F G Dos Santos, Thelma Larocca Skare
BACKGROUND: Antineutrophil cytoplasmatic antibodies (ANCA) have been detected in patients with systemic lupus erythematosus (SLE). In this study, we investigated the presence of ANCA in a sample of Brazilian SLE patients and its possible associations with clinical and serological outcomes. Additionally, we reviewed the literature of on ANCA in SLE. RESULTS: The presence of ANCA was detected in 130 patients using indirect immunofluorescence (IIF). The test was positive in 29...
March 20, 2024: Lupus
https://read.qxmd.com/read/38491423/subclinical-synovitis-impact-on-the-progression-of-lupus-joint-disease-a-10-year-longitudinal-multicenter-study
#8
JOURNAL ARTICLE
Carlos A Guillén-Astete, Marcelino Revenga-Martínez, Antonio C Zea-Mendoza, María E Brito-Brito, Pablo Zurita-Prada, Claudia Urrego-Laurín, Lourdes Villalobos-Sánchez, Nuria García-Montes, Mónica Vázquez-Díaz
OBJECTIVE: To determine the effect of subclinical synovitis on the progression of joint disease in a cohort of patients with systemic lupus erythematosus over a mean follow-up of 10 years. METHODS: A longitudinal follow-up of 96 patients diagnosed with lupus was performed. All patients were considered clinically free of joint disease or with minimal joint impairment at baseline and were studied through ultrasound study of their dominant hand to assess the prevalence of subclinical synovitis...
March 15, 2024: Lupus
https://read.qxmd.com/read/38490946/global-tuberculosis-disease-and-infection-in-systemic-lupus-erythematosus-patients-a-systematic-review-and-meta-analysis
#9
JOURNAL ARTICLE
Guntur Darmawan, Lie Monica Sherine Liman, Suryo Anggoro Kusumo Wibowo, Laniyati Hamijoyo, Lika Apriani, Nur Atik, Bachti Alisjahbana, Edhyana Sahiratmadja
BACKGROUND: Tuberculosis (TB) is one of the most common infections among systemic lupus erythematosus (SLE) patients. We aimed to evaluate the global prevalence of TB infection and disease, its type, and medication risk factors in SLE patients. METHODS: We searched PubMed, Science Direct, EBSCO, and Web of Science databases from inception to April 30, 2023, and included studies assessing TB among SLE patients. We estimated the prevalence of TB disease (including type of TB disease), TB infection, and SLE medication as TB risk factors...
March 15, 2024: Lupus
https://read.qxmd.com/read/38470859/glucocorticoid-free-remission-in-patients-with-sle-in-the-era-of-biologics-immune-complex-disease-is-likely-to-benefit-from-current-medications
#10
JOURNAL ARTICLE
Hiroshi Oiwa, Takeshi Suga, Yohei Hosokawa, Kei Araki
OBJECTIVES: In addition to various immunosuppressive agents, belimumab and anifrolumab became available in Japan. We aimed to investigate glucocorticoid-free clinical remission in a single-centre retrospective cohort in October 2023. METHODS: Our cohort included patients with SLE who needed to start or increase glucocorticoids for disease activity and were followed up for more than 1 year. We investigated the rate of achievement of clinical remission off corticosteroids (CR off C), defined as no clinical score on the SLEDAI-2K without glucocorticoids, baseline predictors of CR off C, medications used when CR off C was achieved, and flare rates following CR off C...
March 12, 2024: Lupus
https://read.qxmd.com/read/38457921/childhood-adverse-experiences-and-clinical-manifestations-in-women-with-systemic-lupus-erythematosus
#11
JOURNAL ARTICLE
Elisa Esteves Rossini, Jonatas Lourival Zanoveli Cunha, Gabriela L B Costa, Karin Araujo Melo, José Pedro Cassemiro Micheleto, Vanessa Miranda Pereira Fausto, Laís Quintiliano Pedroza, Thiago Sotero Fragoso, Valfrido Leão de Melo Neto, Michelle Jacintha Cavalcante Oliveira
BACKGROUND: Patients with a history of adverse childhood experiences (ACEs) have a higher incidence of developing autoimmune diseases such as systemic lupus erythematosus. OBJECTIVE: The objective is to associate the ACE with the clinical manifestations of SLE in adult women. METHODS: This is a cross-sectional observational analytical study in a sample of women diagnosed with SLE, whose data were collected through interviews and a review of medical records...
March 8, 2024: Lupus
https://read.qxmd.com/read/38457835/using-combination-of-albumin-to-fibrinogen-ratio-and-prognostic-nutritional-index-model-for-predicting-disease-activity-in-patients-with-systemic-lupus-erythematosus
#12
JOURNAL ARTICLE
Hongshuai Zhao, Zikun Huang, Shiqian Wang, Peng Fu, Biqi Fu, Yang Guo, Junming Li, Qing Luo
Background: Systemic lupus erythematosus (SLE) is chronic autoimmune disease with multiple organ damage and is associated with poor prognosis and high mortality. Identification of universal biomarkers to predict SLE activity is challenging due to the heterogeneity of the disease. This study aimed to identify the indicators that are sensitive and specific to predict activity of SLE. Methods: We retrospectively analyzed 108 patients with SLE. Patients were categorized into SLE with activity and without activity groups on the basis of SLE disease activity index...
March 8, 2024: Lupus
https://read.qxmd.com/read/38456833/early-add-on-use-of-belimumab-as-induction-therapy-for-patients-with-childhood-onset-systemic-lupus-erythematosus
#13
LETTER
Shun Hashimoto, Masashi Fujita, Tomomi Aizawa, Shojiro Watanabe, Koji Tsugawa, Hiroshi Tanaka
No abstract text is available yet for this article.
March 8, 2024: Lupus
https://read.qxmd.com/read/38454796/comparison-of-late-onset-and-non-late-onset-systemic-lupus-erythematosus-individuals-in-a-real-world-electronic-health-record-cohort
#14
JOURNAL ARTICLE
Ganiat Adeogun, Alex Camai, Ashley Suh, Lee Wheless, April Barnado
Objective: Late-onset systemic lupus erythematosus (LO-SLE) is defined as SLE diagnosed at age 50 years or later. Current studies on LO-SLE are small and have conflicting results. Methods: Using a large, electronic health record (EHR)-based cohort of SLE individuals, we compared demographics, disease characteristics, SLE-specific antibodies, and medication prescribing practices in LO ( n = 123) vs. NLO-SLE ( n = 402) individuals. Results: The median age (interquartile range) at SLE diagnosis was 60 (56-67) years for LO-SLE and 28 (20-38) years for NLO-SLE...
March 7, 2024: Lupus
https://read.qxmd.com/read/38446533/satisfaction-and-effectiveness-of-switching-from-intravenous-to-subcutaneous-belimumab-treatment-in-daily-clinical-practice
#15
JOURNAL ARTICLE
Beatriz Frade-Sosa, Tarek Carlos Salman-Monte, Javier Narváez, Irene Peralta, Sebastian Sandoval, Berta Magallares, Sergi Heredia, Nuria Sapena, Anne Riveros-Frutos, Alejandro Olivé, Hector Corominas, Josefina Cortés-Hernández, José A Gómez-Puerta
BACKGROUND: In 2017, belimumab (BEL) was approved in subcutaneous (SQ) administration. The effectiveness after switching from intravenous (IV) to SQ and patient satisfaction in daily clinical practice has not been studied. During the pandemic, patient follow-up and treatment were significantly affected, and some patients need a change from IV to SQ. Our aim was to evaluate daily clinical practice satisfaction to SQ BEL therapy in patients previously treated IV BEL. We hypothesized that SQ BEL in SLE patients previously treated with IV BEL was similar in effectiveness and conferred higher satisfaction...
March 6, 2024: Lupus
https://read.qxmd.com/read/38445483/comparison-of-the-sle-risk-probability-index-slerpi-scale-against-the-european-league-against-rheumatism-american-college-of-rheumatology-acr-eular-and-systemic-lupus-international-collaborating-clinics-slicc-criteria
#16
JOURNAL ARTICLE
Juan Pablo Castañeda-González, Silvia Alejandra Mogollón Hurtado, Adriana Rojas-Villarraga, Diana Guavita-Navarro, Laura Gallego-Cardona, Ana María Arredondo, Héctor Cubides, Claudia Ibáñez, Alejandro Escobar, Jairo Cajamarca-Barón
INTRODUCTION: Timely diagnosis and proper recognition of Systemic Lupus Erythematosus (SLE) is essential to establish early management in inpatients and outpatients. There are different classification scales to identify SLE, which include various clinical and serological aspects. In 2021, the SLE Risk Probability Index (SLERPI) was published, which focuses predominantly on the clinical characteristics of patients with suspected SLE and uses a simple algorithm for early recognition of the disease...
March 6, 2024: Lupus
https://read.qxmd.com/read/38444066/skin-erythematous-migrant-lesions-consistent-with-histologically-confirmed-dermal-arteriolar-thrombosis-connected-to-aps
#17
JOURNAL ARTICLE
Silvia Suardi, Jacopo Croce, Chiara Colato, Paola Chiara Rizzo, Simonetta Friso, Francesca Pizzolo
Antiphospholipid syndrome (APS) is an acquired thrombophilic disorder related to the presence of antiphospholipid antibodies (LAC, anticardiolipin, anti Beta2-glycoprotein) known to cause venous and arterial thrombosis and recurrent pregnancy loss. Skin disorder is a frequent finding usually due to vascular thrombosis involving the dermal layer and can be either localized or widespread causing necrosis and ulceration of the skin, without histological evidence of vasculitis. We present a case of a woman with APS with both arterial and venous thrombotic involvement associated with an atypical dermatological manifestation histologically consistent with a pauci-inflammatory intermediate-deep dermal arteriolar platelet-mediated thrombosis that appeared despite anticoagulation with warfarin and responding to the addition of antiplatelet therapy...
March 5, 2024: Lupus
https://read.qxmd.com/read/38442229/positive-psychological-capital-post-traumatic-growth-social-support-and-quality-of-life-in-patients-with-systemic-lupus-erythematosus-a-cross-sectional-study
#18
JOURNAL ARTICLE
Lyu Meng, Cui-Rong Gao, Hui-Cai Wang, Raxida Yasin, Rui-Jie Huang, Yu-Xin Zhao, Xiao-Hui Ma, Yuan-Yuan Wen
OBJECTIVE: This study aimed to investigate the correlation between positive psychological capital, post-traumatic growth, social support, and quality of life (QOL) in patients with systemic lupus erythematosus (SLE). METHODS: A cross-sectional study was conducted at the First Affiliated Hospital of Xinjiang Medical University from October 2022 to May 2023. A sample of 330 hospitalized SLE patients was selected for this study. The collected data included demographic information, the SLE disease activity index, the Positive Mental Capital Questionnaire, the Chinese version of the Post-Traumatic Growth Scale, the Social Support Rating Scale, and the Chinese version of the Lupus Quality of Life Scale...
March 5, 2024: Lupus
https://read.qxmd.com/read/38414428/life-expectancy-and-death-pattern-associated-with-systemic-lupus-erythematosus-diagnosis-in-brazil-between-2000-and-2019
#19
JOURNAL ARTICLE
Edgard Torres Dos Reis-Neto, Odirlei Andre Monticielo, Milena Daher, Flávia Lopes, Daniel Angrimani, Evandro Mendes Klumb
OBJECTIVES: to evaluate the main factors associated with mortality and determine the life expectancy of SLE patients between 2000 and 2019 years in Brazil. METHODS: death data related to SLE available in the Brazilian Unified Health System (SUS) (DATASUS) were evaluated in all Brazilian states. Three groups of death causes potentially associated from SLE were evaluated: cardiovascular and kidney diseases and infections. RESULTS: The main causes of death associated with SLE were infection and kidney disease...
February 28, 2024: Lupus
https://read.qxmd.com/read/38413920/impact-of-preeclampsia-on-infant-and-maternal-health-among-women-with-rheumatic-diseases
#20
JOURNAL ARTICLE
Megan E Milne, Megan Eb Clowse, Congwen Zhao, Benjamin A Goldstein, Amanda M Eudy
OBJECTIVES: We sought to identify the impact of preeclampsia on infant and maternal health among women with rheumatic diseases. METHODS: A retrospective single-center cohort study was conducted to describe pregnancy and infant outcomes among women with systemic lupus erythematosus (SLE) with and without preeclampsia as compared to women with other rheumatic diseases with and without preeclampsia. RESULTS: We identified 263 singleton deliveries born to 226 individual mothers (mean age 31 years, 35% non-Hispanic Black)...
February 27, 2024: Lupus
journal
journal
20193
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.