Liver Transplantation

No abstract text is available yet for this article.

No abstract text is available yet for this article.

An ischemia-reperfusion injury (IRI) results from a prolonged ischemic insult followed by the restoration of blood perfusion, being a common cause of morbidity and mortality, especially in liver transplantation. At the maximum of the potential damage, IRI is characterized by 2 main phases. The first is the ischemic phase, where the hypoxia and vascular stasis induces cell damage and the accumulation of damage-associated molecular patterns and cytokines. The second is the reperfusion phase, where the local sterile inflammatory response driven by innate immunity leads to a massive cell death and impaired liver functionality...

No abstract text is available yet for this article.

BACKGROUND & AIMS: Elevated Protein Induced by Vitamin-K Absence-II (PIVKA-II) has been shown to be an adverse prognostic factor in hepatocellular cancer (HCC) patients undergoing liver transplantation (LT). No definitive data are available about the impact of PIVKA-II concerning post-LT recurrence in patients not secreting (≤20 ng/mL) alpha-fetoprotein (AFP). APPROACH & RESULTS: An observational retrospective study of the East-West HCC-LT consortium is reported...

Post-transplant lymphoproliferative disease (PTLD) is a rare but serious complication of liver transplantation (LT) with morbidity and mortality. The risk factors for PTLD in adults are ill-defined. The current study aimed to assess the risk factors for PTLD after LT in adults. All adult LT recipients between 1986 and 2016 from two centers in the Netherlands were included, with follow-up until 2020. PTLD was diagnosed according to the WHO classification. Potential risk factors for PTLD were assessed using multivariate Cox regression analysis...

OBJECTIVES: This study aimed to evaluate the effectiveness of different treatments for hepatic artery thrombosis (HAT) and hepatic artery stenosis (HAS) after pediatric liver transplantation (pLT). METHODS: We systematically reviewed studies published since 2000 that investigated the management of HAT and/or HAS after pLT. Studies with a minimum of 5 patients in one of the treatments methods were included. The primary outcomes were technical success rate and graft and patient survival...

No abstract text is available yet for this article.

BACKGROUND: Steroid-free immunosuppression protocols gained popularity in paediatric liver transplantation (pLT) after the introduction of Interleukin-2-receptor blockade for induction therapy. We analyzed clinical and immunological outcome data of the multicenter prospective observational ChilSFree study in order to compare impact of steroid-free vs. steroid-containing immunosuppressive therapy following pLT in a real-life scenario. RESULTS: 246 children (55.3% male, age at pLT median 2...

No abstract text is available yet for this article.

BACKGROUND AND AIMS: The model of end-stage liver disease (MELD) score has been employed to identify liver transplantation in adolescents since 2004. However, the optimal model or prioritizing adolescent candidates is uncertain. In our study we aimed at evaluating the value of adding anthropometric variables to liver transplantation allocation models among adolescents. METHODS: We conducted a retrospective cohort study using data from the OPTN Standard Transplant Analysis and Research (STAR) to identify adolescent patients registered on the liver transplant waiting list in the United States between January 1, 2003 and December 31st 2022...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

PURPOSE: Transarterial chemoembolization (TACE) and radioembolization (TARE) are two most used modalities for patients with hepatocellular carcinoma (HCC) while awaiting liver transplant (LT). The purpose of this study is to perform a cost-effectiveness analysis comparing TACE and TARE for downstaging patients with HCC. METHODS: A cost-effectiveness analysis was performed comparing TACE and TARE in downstaging HCC over a 5-year time horizon from a payer's perspective...

RATIONALE: The exception point system for liver allocation in the United States allows for additional waitlist priority for candidates where the Model for End-Stage Liver Disease or Pediatric End-Stage Liver Disease does not effectively represent their urgency or need for transplant. In May 2019, the review process for liver exception cases transitioned from 11 Regional Review Boards (RRBs) to one National Liver Review Board (NLRB), intended to increase consistency nationwide, improve efficiency, and balance transplant access for candidates with and without exception scores...

BACKGROUND: With increasing metabolic dysfunction associated steatotic liver disease (MASLD), the use of steatotic grafts in liver transplantation (LT) and their impact on postoperative graft survival (GS) needs further exploration. METHOD: Analyzing adult LT recipient data (2002-2022) from the United Network for Organ Sharing database, outcomes of LT using steatotic (≥30% macrosteatosis) and non-steatotic donor livers, donors after circulatory death (DCD), and standard-risk older donors (age 45-50) were compared...

No abstract text is available yet for this article.

The long-term (>5 y) outcomes following liver transplantation (LT) have not been extensively reported. The aim was to evaluate outcomes of LT recipients who have survived the first 5 years. A multicenter retrospective analysis of prospectively collected data from 3 high volume LT centers (Dallas-USA, Birmingham-UK, and Barcelona-Spain) was undertaken. All adult patients, who underwent LT since the inception of the program to December 31, 2010, and survived at least 5 years since their LT were included...

No abstract text is available yet for this article.

No abstract text is available yet for this article.