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JOURNAL ARTICLE
Yanira Zeyn, Kristin Hausmann, Melisa Halilovic, Mandy Beyer, Hany S Ibrahim, Walburgis Brenner, Siavosh Mahboobi, Matthias Bros, Wolfgang Sippl, Oliver H Krämer
No abstract text is available yet for this article.
September 21, 2023: Leukemia
#2
JOURNAL ARTICLE
A S Kubasch, P Peterlin, T Cluzeau, K S Götze, K Sockel, R Teipel, M Jentzsch, H Attalah, M Sebert, F Chermat, S Gloaguen, M Puttrich, M Cross, M Schneider, S Kayser, D Schipp, A Giagounidis, I Tirado-Gonzalez, A Descot, A van de Loosdrecht, A Weigert, K H Metzeler, P Fenaux, H Medyouf, U Platzbecker, L Ades
No abstract text is available yet for this article.
September 21, 2023: Leukemia
#3
JOURNAL ARTICLE
Long Chang, Bing Qiao, Hao Cai, He Lin, Ming-Hui Duan, Jian Li, Dao-Bin Zhou, Gaurav Goyal, Chun-Yan Sun, Xin-Xin Cao
No abstract text is available yet for this article.
September 20, 2023: Leukemia
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JOURNAL ARTICLE
Michael Lauseker, Rüdiger Hehlmann, Andreas Hochhaus, Susanne Saußele
Therapy after failing response milestones in CML is controversial. Risks associated with comorbidities, drug toxicities or transplantation may preclude switching to another tyrosine kinase inhibitor (TKI) or other treatments. No information on long-term survival of failing patients is available. To systematically analyse survival after reaching, or not reaching, response milestones, 1342 patients from CML-study IV with newly diagnosed CML in chronic phase and regular molecular tests were studied. Landmark survival analyses were done by <0...
September 19, 2023: Leukemia
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Alison Domingues, Elisa Rossi, Kamila Bujko, Grégoire Detriche, Ulysse Richez, Adeline Blandinieres, Magdalena Kucia, Janina Ratajczak, David M Smadja, Mariusz Z Ratajczak
No abstract text is available yet for this article.
September 18, 2023: Leukemia
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LETTER
Angelica Macauda, Klara Briem, Alyssa Clay-Gilmour, Wendy Cozen, Asta Försti, Matteo Giaccherini, Chiara Corradi, Juan Sainz, Yasmeen Niazi, Rob Ter Horst, Yang Li, Mihai G Netea, Ulla Vogel, Kari Hemminki, Susan L Slager, Judit Varkonyi, Vibeke Andersen, Elzbieta Iskierka-Jazdzewska, Joaquin Mártinez-Lopez, Jan Zaucha, Nicola J Camp, S Vincent Rajkumar, Agnieszka Druzd-Sitek, Parveen Bhatti, Stephen J Chanock, Shaji K Kumar, Edyta Subocz, Grzegorz Mazur, Stefano Landi, Mitchell J Machiela, Andrés Jerez, Aaron D Norman, Michelle A T Hildebrandt, Katalin Kadar, Sonja I Berndt, Elad Ziv, Gabriele Buda, Arnon Nagler, Charles Dumontet, Malgorzata Raźny, Marzena Watek, Aleksandra Butrym, Norbert Grzasko, Marek Dudzinski, Malwina Rybicka-Ramos, Eva-Laure Matera, Ramón García-Sanz, Hartmut Goldschmidt, Krzysztof Jamroziak, Artur Jurczyszyn, Esther Clavero, Graham G Giles, Matteo Pelosini, Daria Zawirska, Marcin Kruszewski, Herlander Marques, Eva Haastrup, José Manuel Sánchez-Maldonado, Uta Bertsch, Marcin Rymko, Marc-Steffen Raab, Elizabeth E Brown, Jonathan N Hofmann, Celine Vachon, Daniele Campa, Federico Canzian
No abstract text is available yet for this article.
September 18, 2023: Leukemia
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LETTER
Wei Jiang, Selmir Avdic, Koon H Lee, Janine Street, Gloria Castellano-González, Renee Simms, Leighton E Clancy, Richard Blennerhassett, Ellis Patrick, Adam S Chan, Helen M McGuire, Nadav Myers, Brian S Gloss, Melissa Gabriel, Caroline M Bateman, Ken Micklethwaite, David J Gottlieb, Emily Blyth
No abstract text is available yet for this article.
September 15, 2023: Leukemia
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JOURNAL ARTICLE
Wenxin Du, Zhimei Xia, Zebin Luo, Yichang Chen, Shaowei Bing, Wei Wang, Xingya Zhang, Zhan Zhou, Jingying Zhang, Ji Cao, Bo Yang, Qiaojun He, Xuejing Shao, Xiaojun Xu, Meidan Ying
No abstract text is available yet for this article.
September 15, 2023: Leukemia
#9
JOURNAL ARTICLE
Monika Burocziova, Petr Danek, Anna Oravetzova, Zuzana Chalupova, Meritxell Alberich-Jorda, Libor Macurek
Hematopoietic stem cells (HSCs) ensure blood cell production during the life-time of an organism, and to do so they need to balance self-renewal, proliferation, differentiation, and migration in a steady state as well as in response to stress or injury. Importantly, aberrant proliferation of HSCs leads to hematological malignancies, and thus, tight regulation by various tumor suppressor pathways, including p53, is essential. Protein phosphatase magnesium-dependent 1 delta (PPM1D) is a negative regulator of p53 and promotes cell survival upon induction of genotoxic stress...
September 14, 2023: Leukemia
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REVIEW
Yahui Feng, Saibing Qi, Xueou Liu, Li Zhang, Yu Hu, Qiujin Shen, Xiaowen Gong, Wei Zhang, Junxia Wang, Wen Yan, Tiantian Wang, Huijun Wang, Zhen Song, Xiaofan Zhu, Robert Peter Gale, Junren Chen
No abstract text is available yet for this article.
September 13, 2023: Leukemia
#11
EDITORIAL
Robert Peter Gale, Andreas Hochhaus
No abstract text is available yet for this article.
September 12, 2023: Leukemia
#12
JOURNAL ARTICLE
Shiqi Li, Xinxin Wang, Lin Liu, Jia Liu, Jun Rao, Zhongtao Yuan, Li Gao, Yu Li, Le Luo, Gui Li, Zhimin Li, Sheng Li, Jiaping He, Lihua Zhang, Lvzhe Chen, Wenhui Huang, Ping Yin, Chunmin Li, Xiaoping Li, Youcheng Wang, Yancheng Dong, Dingsong Zhang, Qingying Zang, Yingnian Chen, Lianjun Shen, Wenling Li, Wei Cao, Xi Zhang, Sanbin Wang
T-cell acute lymphoblastic leukemia (T-ALL) represents an area of highly unmet medical needs. Once relapsed, patients have limited treatment options and poor prognosis. T-ALL antigens such as CD7 is extensively expressed in normal T cells and natural killer (NK) cells, and extending the success of CAR-T therapy to T cell malignancies was challenged by CAR-T cell fratricide, high production cost, and potential product contaminations. GC027 is an "off-the-shelf" allogeneic CD7 targeted CAR-T therapeutic product for T cell malignancies...
September 12, 2023: Leukemia
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JOURNAL ARTICLE
Alisa Olkinuora, Taina T Nieminen, Suvi Douglas, Anni Kauppinen, Mika Kontro, Juho Väänänen, Matti Kankainen, Ari Ristimäki, Markus Mäkinen, Päivi Lahermo, Caroline Heckman, Janna Saarela, Milla Salonen, Anna Lepistö, Heikki Järvinen, Jukka-Pekka Mecklin, Outi Kilpivaara, Ulla Wartiovaara-Kautto, Kimmo Porkka, Päivi Peltomäki
No abstract text is available yet for this article.
September 11, 2023: Leukemia
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JOURNAL ARTICLE
Kasidy K Dobish, Karli J Wittorf, Samantha A Swenson, Dalton C Bean, Catherine M Gavile, Nicholas T Woods, Gargi Ghosal, R Katherine Hyde, Shannon M Buckley
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by clonal expansion of myeloid blasts in the bone marrow (BM). Despite advances in therapy, the prognosis for AML patients remains poor, and there is a need to identify novel molecular pathways regulating tumor cell survival and proliferation. F-box ubiquitin E3 ligase, FBXO21, has low expression in AML, but expression correlates with survival in AML patients and patients with higher expression have poorer outcomes. Silencing FBXO21 in human-derived AML cell lines and primary patient samples leads to differentiation, inhibition of tumor progression, and sensitization to chemotherapy agents...
September 9, 2023: Leukemia
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JOURNAL ARTICLE
Caitlyn Vlasschaert, Elvis Akwo, Cassianne Robinson-Cohen, Elina K Cook, Matthew B Lanktree, Michael J Rauh, Alexander G Bick
No abstract text is available yet for this article.
September 9, 2023: Leukemia
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JOURNAL ARTICLE
Jan-Niklas Eckardt, Marius Bill, Christian Rausch, Klaus Metzeler, Karsten Spiekermann, Sebastian Stasik, Tim Sauer, Sebastian Scholl, Andreas Hochhaus, Martina Crysandt, Tim H Brümmendorf, Utz Krug, Bernhard Wörmann, Wolfgang Hiddemann, Dennis Görlich, Cristina Sauerland, Björn Steffen, Hermann Einsele, Andreas Neubauer, Andreas Burchert, Kerstin Schäfer-Eckart, Wolfgang E Berdel, Christoph Schliemann, Stefan W Krause, Mathias Hänel, Maher Hanoun, Martin Kaufmann, Lars Fransecky, Jan Braess, Leo Ruhnke, Johannes Schetelig, Jan Moritz Middeke, Hubert Serve, Claudia D Baldus, Uwe Platzbecker, Carsten Müller-Tidow, Martin Bornhäuser, Tobias Herold, Christian Thiede, Christoph Röllig
No abstract text is available yet for this article.
September 7, 2023: Leukemia
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JOURNAL ARTICLE
Tommaso Sconocchia, Johannes Foßelteder, Lisa Auinger, Erdem Özkaya, Theresa Benezeder, Magdalena Lang, Christine Beham-Schmid, Gerald Hoefler, Armin Zebisch, Albert Wölfler, Heinz Sill, Peter Wolf, Herbert Strobl, Andreas Reinisch
No abstract text is available yet for this article.
September 6, 2023: Leukemia
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JOURNAL ARTICLE
Karin Bauer, Sigrid Machherndl-Spandl, Lukas Kazianka, Irina Sadovnik, Sinan Gültekin, Susanne Suessner, Johannes Proell, Jeroen Lauf, Gregor Hoermann, Gregor Eisenwort, Norman Häfner, Mathilde Födermayr-Mayrleitner, Ann-Sofie Schmolke, Emiel van der Kouwe, Uwe Platzbecker, Thomas Lion, Ansgar Weltermann, Otto Zach, Gerald Webersinke, Ulrich Germing, Christian Gabriel, Wolfgang R Sperr, Marie C Béné, Philipp B Staber, Peter Bettelheim, Peter Valent
Myelodysplastic syndromes (MDS) are myeloid neoplasms presenting with dysplasia in the bone marrow (BM) and peripheral cytopenia. In most patients anemia develops. We screened for genes that are expressed abnormally in erythroid progenitor cells (EP) and contribute to the pathogenesis of MDS. We found that the Coxsackie-Adenovirus receptor (CAR = CXADR) is markedly downregulated in CD45low /CD105+ EP in MDS patients compared to control EP. Correspondingly, the erythroblast cell lines HEL, K562, and KU812 stained negative for CAR...
September 6, 2023: Leukemia
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JOURNAL ARTICLE
Yongguang Zhang, Danfeng Lin, Yongwei Zheng, Yuhong Chen, Mei Yu, Dongya Cui, Miaohui Huang, Xinlin Su, Yong Sun, Yabing Chen, Zhijian Qian, Karen-Sue Carlson, Renren Wen, Demin Wang
The highly conserved MicroRNA-9 (miR-9) family consists of three members. We discovered that miR-9-1 deletion reduced mature miR-9 expression, causing 43% of the mice to display smaller size and postweaning lethality. MiR-9-1-deficient mice with growth defects experienced severe lymphopenia, but other blood cells were unaffected. The lymphopenia wasn't due to defects in hematopoietic progenitors, as mutant bone marrow (BM) cells underwent normal lymphopoiesis after transplantation into wild-type recipients...
September 5, 2023: Leukemia
#20
Sonja I Berndt, Joseph Vijai, Yolanda Benavente, Nicola J Camp, Alexandra Nieters, Zhaoming Wang, Karin E Smedby, Geffen Kleinstern, Henrik Hjalgrim, Caroline Besson, Christine F Skibola, Lindsay M Morton, Angela R Brooks-Wilson, Lauren R Teras, Charles Breeze, Joshua Arias, Hans-Olov Adami, Demetrius Albanes, Kenneth C Anderson, Stephen M Ansell, Bryan Bassig, Nikolaus Becker, Parveen Bhatti, Brenda M Birmann, Paolo Boffetta, Paige M Bracci, Paul Brennan, Elizabeth E Brown, Laurie Burdett, Lisa A Cannon-Albright, Ellen T Chang, Brian C H Chiu, Charles C Chung, Jacqueline Clavel, Pierluigi Cocco, Graham Colditz, Lucia Conde, David V Conti, David G Cox, Karen Curtin, Delphine Casabonne, Immaculata De Vivo, Arjan Diepstra, W Ryan Diver, Ahmet Dogan, Christopher K Edlund, Lenka Foretova, Joseph F Fraumeni, Attilio Gabbas, Hervé Ghesquières, Graham G Giles, Sally Glaser, Martha Glenn, Bengt Glimelius, Jian Gu, Thomas M Habermann, Christopher A Haiman, Corinne Haioun, Jonathan N Hofmann, Theodore R Holford, Elizabeth A Holly, Amy Hutchinson, Aalin Izhar, Rebecca D Jackson, Ruth F Jarrett, Rudolph Kaaks, Eleanor Kane, Laurence N Kolonel, Yinfei Kong, Peter Kraft, Anne Kricker, Annette Lake, Qing Lan, Charles Lawrence, Dalin Li, Mark Liebow, Brian K Link, Corrado Magnani, Marc Maynadie, James McKay, Mads Melbye, Lucia Miligi, Roger L Milne, Thierry J Molina, Alain Monnereau, Rebecca Montalvan, Kari E North, Anne J Novak, Kenan Onel, Mark P Purdue, Kristin A Rand, Elio Riboli, Jacques Riby, Eve Roman, Gilles Salles, Douglas W Sborov, Richard K Severson, Tait D Shanafelt, Martyn T Smith, Alexandra Smith, Kevin W Song, Lei Song, Melissa C Southey, John J Spinelli, Anthony Staines, Deborah Stephens, Heather J Sutherland, Kaitlyn Tkachuk, Carrie A Thompson, Hervé Tilly, Lesley F Tinker, Ruth C Travis, Jenny Turner, Celine M Vachon, Claire M Vajdic, Anke Van Den Berg, David J Van Den Berg, Roel C H Vermeulen, Paolo Vineis, Sophia S Wang, Elisabete Weiderpass, George J Weiner, Stephanie Weinstein, Nicole Wong Doo, Yuanqing Ye, Meredith Yeager, Kai Yu, Anne Zeleniuch-Jacquotte, Yawei Zhang, Tongzhang Zheng, Elad Ziv, Joshua Sampson, Nilanjan Chatterjee, Kenneth Offit, Wendy Cozen, Xifeng Wu, James R Cerhan, Stephen J Chanock, Susan L Slager, Nathaniel Rothman
No abstract text is available yet for this article.
September 4, 2023: Leukemia
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