Linda R Mileshkin, Kathleen N Moore, Elizabeth H Barnes, Val Gebski, Kailash Narayan, Madeleine T King, Nathan Bradshaw, Yeh Chen Lee, Katrina Diamante, Anthony W Fyles, William Small, David K Gaffney, Pearly Khaw, Susan Brooks, J Spencer Thompson, Warner K Huh, Cara A Mathews, Martin Buck, Aneta Suder, Thomas E Lad, Igor J Barani, Christine H Holschneider, Sylvia Van Dyk, Michael Quinn, Danny Rischin, Bradley J Monk, Martin R Stockler
BACKGROUND: Standard treatment for locally advanced cervical cancer is chemoradiotherapy, but many patients relapse and die of metastatic disease. We aimed to determine the effects on survival of adjuvant chemotherapy after chemoradiotherapy. METHODS: The OUTBACK trial was a multicentre, open-label, randomised, phase 3 trial done in 157 hospitals in Australia, China, Canada, New Zealand, Saudi Arabia, Singapore, and the USA. Eligible participants were aged 18 year or older with histologically confirmed squamous cell carcinoma, adenosquamous cell carcinoma, or adenocarcinoma of the cervix (FIGO 2008 stage IB1 disease with nodal involvement, or stage IB2, II, IIIB, or IVA disease), Eastern Cooperative Oncology Group performance status 0-2, and adequate bone marrow and organ function...
April 17, 2023: Lancet Oncology