journal
https://read.qxmd.com/read/38401706/quantitative-assessment-of-glomerular-basement-membrane-collagen-iv-%C3%AE-chains-in-paraffin-sections-from-patients-with-focal-segmental-glomerulosclerosis-and-alport-gene-variants
#41
JOURNAL ARTICLE
Pongpratch Puapatanakul, Suramath Isaranuwatchai, Ankanee Chanakul, Jerasit Surintrspanont, Kroonpong Iampenkhae, Talerngsak Kanjanabuch, Kanya Suphapeetiporn, Vivek Charu, Hani Y Suleiman, Kearkiat Praditpornsilpa, Jeffrey H Miner
Focal segmental glomerulosclerosis (FSGS) lesions have been linked to variants in COL4A3/A4/A5 genes, which are also mutated in Alport syndrome. Although it could be useful for diagnosis, quantitative evaluation of glomerular basement membrane (GBM) type IV collagen (colIV) networks is not widely used to assess these patients. To do so, we developed immunofluorescence imaging for collagen α5(IV) and α1/2(IV) on kidney paraffin sections with Airyscan confocal microscopy that clearly distinguishes GBM collagen α 3 α 4 α5(IV) and α 1 α 1 α2(IV) as two distinct layers, allowing quantitative assessment of both colIV networks...
February 22, 2024: Kidney International
https://read.qxmd.com/read/38395410/the-role-of-desmoglein-2-in-kidney-disease
#42
JOURNAL ARTICLE
Tong Xu, Lea Herkens, Ting Jia, Barbara M Klinkhammer, Sebastian Kant, Claudia A Krusche, Eva M Buhl, Sikander Hayat, Jürgen Floege, Pavel Strnad, Rafael Kramann, Sonja Djudjaj, Peter Boor
Desmosomes are multi-protein cell-cell adhesion structures supporting cell stability and mechanical stress resilience of tissues; best described in skin and heart. The kidney is exposed to various mechanical stimuli and stress, yet little is known about kidney desmosomes. In healthy kidneys, we found desmosomal proteins located at the apical-junctional complex in tubular epithelial cells. In four different animal models and patient biopsies with various kidney diseases, desmosomal components were significantly upregulated and partly miss-localized outside of the apical-junctional complexes along the whole lateral tubular epithelial cell membrane...
February 21, 2024: Kidney International
https://read.qxmd.com/read/38387504/disrupting-circadian-control-of-autophagy-induces-podocyte-injury-and-proteinuria
#43
JOURNAL ARTICLE
Lulu Wang, Han Tian, Haiyan Wang, Xiaoming Mao, Jing Luo, Qingyun He, Ping Wen, Hongdi Cao, Li Fang, Yang Zhou, Junwei Yang, Lei Jiang
The circadian clock influences a wide range of biological process and controls numerous aspects of physiology to adapt to the daily environmental changes caused by Earth's rotation. The kidney clock plays an important role in maintaining tubular function, but its effect on podocytes remains unclear. Here, we found that podocytes expressed CLOCK proteins, and that 2666 glomerular gene transcripts (13.4%), including autophagy related genes, had 24-hour circadian rhythms. Deletion of Clock in podocytes resulted in 1666 gene transcripts with the loss of circadian rhythm including autophagy genes...
February 20, 2024: Kidney International
https://read.qxmd.com/read/38382843/reassuring-pregnancy-outcomes-in-women-with-mild-col4a3-5-related-disease-alport-syndrome-as-the-genetic-type-of-disease-can-aid-personalized-counseling
#44
JOURNAL ARTICLE
Margriet E Gosselink, Rozemarijn Snoek, Agne Cerkauskaite-Kerpauskiene, Sophie P J van Bakel, Renee Vollenberg, Henk Groen, Rimante Cerkauskiene, Marius Miglinas, Rossella Attini, Kálmán Tory, Kathleen Claes, Kristel van Calsteren, Aude Servais, Margriet F C de Jong, Valentine Gillion, Liffert Vogt, Antonio Mastrangelo, Monica Furlano, Roser Torra, Kate Bramham, Kate Wiles, Elizabeth R Ralston, Matthew Hall, Lisa Liu, Michelle A Hladunewich, Titia Lely, Albertien M van Eerde
Individualized pre-pregnancy counseling and antenatal care for women with chronic kidney disease (CKD) require disease-specific data. Here, we investigated pregnancy outcomes and long-term kidney function in women with COL4A3-5 related disease (Alport Syndrome, (AS)) in a large multicenter cohort. The ALPART-network (mAternaL and fetal PregnAncy outcomes of women with AlpoRT syndrome), an international collaboration of 17 centers, retrospectively investigated COL4A3-5 related disease pregnancies after the 20th week...
February 19, 2024: Kidney International
https://read.qxmd.com/read/38642993/levamisole-in-childhood-idiopathic-nephrotic-syndrome-new-promises-and-advocacy-for-global-access
#45
JOURNAL ARTICLE
Eugene Yu-Hin Chan, Olivia Boyer
In the current issue of Kidney International, Sinha et al. present data from an open-label, noninferior, randomized controlled trial comparing 12-months of alternate-day prednisolone, given daily during infection, versus levamisole, in children with frequently relapsing or steroid-dependent nephrotic syndrome. This study suggests that both of these strategies are efficacious and safe. Results of this study should redefine the role of levamisole in future guidelines, and a call for global availability of levamisole should be advocated...
May 2024: Kidney International
https://read.qxmd.com/read/38642992/seeing-through-the-density-of-dense-deposit-disease
#46
JOURNAL ARTICLE
Charles E Alpers
Little is known about what constitutes the dense deposits of dense deposit disease (DDD), apart from components of the complement pathway. This study presents the novel finding that large accumulations of apolipoprotein E are present in the deposits of DDD, as revealed by mass spectroscopy and confirmed by both confocal microscopy and immunohistochemistry. The findings suggest a new modality for diagnosis of DDD and introduce potential new mechanisms for understanding DDD pathophysiology.
May 2024: Kidney International
https://read.qxmd.com/read/38642991/hereditary-hypophosphatemic-rickets-with-hypercalciuria-hhrh-a-complex-disorder-in-need-of-precision-medicine
#47
JOURNAL ARTICLE
Thorsten Schinke, Ralf Oheim
Hereditary hypophosphatemic rickets with hypercalciuria is an autosomal recessive phosphate-wasting disorder, associated with kidney and skeletal pathologies, which is caused by pathogenic variants of SLC34A3. In this issue, Zhu et al. describe a pooled analysis of 304 individuals carrying SLC34A3 variants. Their study underscores the complexity of hereditary hypophosphatemic rickets with hypercalciuria, as kidney and bone phenotypes generally do not coexist, heterozygous carriers of SLC34A3 variants also can be affected, and the response to oral phosphate supplementation is dependent on the genetic status...
May 2024: Kidney International
https://read.qxmd.com/read/38642990/targeting-immune-cell-glutamyl-prolyl-transfer-rna-synthetase-1-eprs1-to-prevent-fibrosis-after-tubulointerstitial-nephritis
#48
JOURNAL ARTICLE
Shishir Kumar Patel, Hamid Rabb
Glutamyl-prolyl-transfer RNA synthetase 1 is an enzyme that connects glutamic acid and proline to transfer RNA during protein synthesis. In this issue, a study by Kang et al. examined the role of the immune cell glutamyl-prolyl-transfer RNA synthetase 1 in toxin-induced tubulointerstitial nephritis mice. The study demonstrated that blocking glutamyl-prolyl-transfer RNA synthetase 1 may be a therapeutic target to attenuate fibrosis after toxin-induced tubulointerstitial nephritis.
May 2024: Kidney International
https://read.qxmd.com/read/38642989/wip1-inhibition-as-a-new-therapeutic-strategy-for-collapsing-glomerulopathy
#49
JOURNAL ARTICLE
Shreeram Akilesh
Collapsing glomerulopathy (CG) is an aggressive variant of focal and segmental glomerulosclerosis. Understanding the diverse mechanisms that can drive CG promises to uncover new therapeutic strategies. In this issue, Duret et al. identify WIP1 phosphatase as a therapeutic target for CG. Using genetic ablation and pharmacologic inhibition, they show that blockade of WIP1 activity is protective in 2 different mouse models of CG. This study highlights the complex interplay of glomerular signaling pathways in CG and offers hope for targeted therapies...
May 2024: Kidney International
https://read.qxmd.com/read/38642988/a-pig-kidney-supporting-human-physiology
#50
JOURNAL ARTICLE
Stuart J Knechtle, Joseph M Ladowski, Jean Kwun
Because of the global shortage of donor kidneys, xenotransplantation emerges as a potential solution for individuals with kidney failure who face challenges in securing a suitable donor kidney. A study featured in this month's issue of Kidney International assesses the kidney physiology of a porcine kidney transplanted into a brain-dead human with kidney failure, demonstrating life-sustaining physiological function for 7 days. Together with preclinical nonhuman primate studies, decedent models provide complementary data for development of clinical kidney xenotransplantation...
May 2024: Kidney International
https://read.qxmd.com/read/38642987/endogenous-adenine-as-a-key-player-in-diabetic-kidney-disease-progression-an-integrated-multiomics-approach
#51
JOURNAL ARTICLE
Yu Ah Hong, Masaomi Nangaku
No abstract text is available yet for this article.
May 2024: Kidney International
https://read.qxmd.com/read/38642986/calprotectin-a-misnomer-for-another-player-in-vascular-calcification
#52
JOURNAL ARTICLE
Tilman B Drueke, Ziad A Massy
No abstract text is available yet for this article.
May 2024: Kidney International
https://read.qxmd.com/read/38642985/the-ottawa-statement-implementation-guidance-document-for-cluster-randomized-trials-in-the-hemodialysis-setting
#53
JOURNAL ARTICLE
Cory E Goldstein, Monica Taljaard, Stuart G Nicholls, Mary Beaucage, Jamie Brehaut, Charles L Cook, Brenden B Cote, Jonathan C Craig, Stephanie N Dixon, Jessica Du Toit, Catherine C S Du Val, Amit X Garg, Jeremy M Grimshaw, Shasikara Kalatharan, Scott Y H Kim, Austin Kinsella, Valerie Luyckx, Charles Weijer
Research teams are increasingly interested in using cluster randomized trial (CRT) designs to generate practice-guiding evidence for in-center maintenance hemodialysis. However, CRTs raise complex ethical issues. The Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials, published in 2012, provides 15 recommendations to address ethical issues arising within 7 domains: justifying the CRT design, research ethics committee review, identifying research participants, obtaining informed consent, gatekeepers, assessing benefits and harms, and protecting vulnerable participants...
May 2024: Kidney International
https://read.qxmd.com/read/38642983/the-case-acute-kidney-injury-in-a-patient-with-systemic-necrotizing-lesions
#54
JOURNAL ARTICLE
Sébastien Kissling, Samuel Rotman, Fadi Fakhouri
No abstract text is available yet for this article.
May 2024: Kidney International
https://read.qxmd.com/read/38642982/b-cell-lymphoma-with-intracellular-crystals-a-mimic-of-crystal-storing-histiocytosis
#55
Michael G Daniel, Craig R Soderquist, Satoru Kudose
No abstract text is available yet for this article.
May 2024: Kidney International
https://read.qxmd.com/read/38642981/bacillus-calmette-gu%C3%A3-rin-induced-kidney-granulomas
#56
Xueyan Zhang, Huixiu Lian, Xiaolei Song, Jun Li
No abstract text is available yet for this article.
May 2024: Kidney International
https://read.qxmd.com/read/38642980/deciphering-interleukin-37-s-therapeutic-potential-insights-into-alleviating-inflammation-in-autosomal-dominant-polycystic-kidney-disease
#57
LETTER
Cheng Xue, Chenchen Zhou, Lijun Sun, Liming Zhang, Zhiguo Mao
No abstract text is available yet for this article.
May 2024: Kidney International
https://read.qxmd.com/read/38431217/assessment-of-epidemiology-and-outcomes-of-adult-patients-with-kidney-limited-thrombotic-microangiopathies
#58
JOURNAL ARTICLE
Valentin Maisons, Anna Duval, Laurent Mesnard, Marie Frimat, Fadi Fakhouri, Steven Grangé, Aude Servais, Claire Cartery, Laurent Fauchier, Paul Coppo, Dimitri Titeca-Beauport, Nicolas Fage, Yahsou Delmas, Anne-Hélène Quérard, Guillaume Seret, Mickaël Bobot, Moglie Le Quintrec, Simon Ville, Florent von Tokarski, Sophie Chauvet, Alain Wynckel, Manon Martins, Juliet Schurder, Christelle Barbet, Bénédicte Sautenet, Philippe Gatault, Sophie Caillard, Vincent Vuiblet, Jean-Michel Halimi
Thrombotic microangiopathies (TMA) are usually associated with hematological features (RH-TMA). The epidemiology of TMA limited to kidneys (RL-TMA) is unclear Therefore, patients with TMA and native kidney biopsies were identified during 2009-2022 in 20 French hospitals and results evaluated. RL-TMA was present in 341/757 (45%) patients and associated with lower creatinine levels (median 184 vs 346 μmol/L) than RH-TMA. RL-TMA resulted from virtually all identified causes, more frequently from anti-VEGF treatment and hematological malignancies but less frequently from shigatoxin-associated hemolytic uremic syndrome (HUS), systemic sclerosis, gemcitabine and bacterial infection, and even less frequently when three or more causes/triggers were combined (RL-TMA: 5%; RH-TMA: 12%)...
May 2024: Kidney International
https://read.qxmd.com/read/38360110/an-open-label-non-inferiority-randomized-controlled-trial-evaluated-alternate-day-prednisolone-given-daily-during-infections-vs-levamisole-in-frequently-relapsing-nephrotic-syndrome
#59
RANDOMIZED CONTROLLED TRIAL
Aditi Sinha, Kshetrimayum Ghanapriya Devi, Suprita Kalra, Kalaivani Mani, Pankaj Hari, Arvind Bagga
Initial therapies for children with frequently relapsing nephrotic syndrome include alternate-day prednisolone that is given daily during infections, or levamisole. In this open label, non-inferiority trial, 160 patients, 2 to 18-years-old with frequent relapses, were randomly assigned to receive either prednisolone (0.5-0.7 mg/kg/alternate-day, given daily during infections), or levamisole (2-2.5 mg/kg/alternate-days) for one-year. Patients with relapses on alternate day prednisolone at over 1 mg/kg, prior use of potent steroid-sparing therapies, eGFR under 60 ml/min/1...
May 2024: Kidney International
https://read.qxmd.com/read/38519244/the-case-proximal-muscle-weakness-hypertension-and-electrolyte-abnormalities
#60
JOURNAL ARTICLE
Katharina W Horn, Suraj S Shah, Devin Skoll, Danielle Carter, Natasha S Freeman, Syed A Husain
No abstract text is available yet for this article.
April 2024: Kidney International
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