Ludovica Lombardi, Francesca Maiorca, Ramona Marrapodi, Annamaria Sabetta, Noemi Scafa, Davide Pallucci, Marzia Miglionico, Giulio F Romiti, Bernadette Corica, Silvia Piconese, Antonella Polimeni, Fabio Pulcinelli, Roberto Cangemi, Marcella Visentini, Stefania Basili, Lucia Stefanini
BACKGROUND: Genetic-based COVID-19 vaccines have proved highly effective in reducing the risk of hospitalization and death. As they were first distributed on a large-scale population, adenoviral-based vaccines were linked to a very rare thrombosis with thrombocytopenia syndrome and the interplay between platelets and vaccinations increasingly gained attention. OBJECTIVE: To study the crosstalk between platelets and the vaccine-induced immune response. METHODS: We prospectively enrolled young healthy volunteers who received the mRNA-based vaccine, BNT162b2 (n=15), or the adenovirus-based vaccine, AZD1222 (n=25) and studied their short-term platelet and immune response before and after vaccine injections...
March 12, 2023: Journal of Thrombosis and Haemostasis: JTH