Ratnashree Biswas, Emily Boyd, Nathan Eaton, Agata Steenackers, Marie L Schulte, Friedrich Reusswig, Hongyin Yu, Caleb Drew, Walter H A Kahr, Qizhen Shi, Markus Plomann, Karin M Hoffmeister, Hervé Falet
BACKGROUND: Upon vessel injury, platelets adhere to exposed matrix constituents via specific membrane receptors, including the von Willebrand factor receptor GPIb-IX-V complex and integrins β1 and β3. In platelets, the F-BAR protein PACSIN2 associates with the cytoskeletal and scaffolding protein filamin A (FlnA), linking GPIbα and integrins to the cytoskeleton. OBJECTIVES: Here we investigated the role of PACSIN2 in platelet function. METHODS: Platelet parameters were evaluated in mice lacking PACSIN2 and platelet integrin β1...
September 5, 2023: Journal of Thrombosis and Haemostasis: JTH