Journal of Thoracic and Cardiovascular Surgery

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OBJECTIVE: To analyze the effectiveness of the current genetic testing guidelines for patients with thoracic aortic aneurysms (TAA). METHODS: We evaluated thoracic aortic disease (TAD) genetic tests from 2012 to 2023 in patients aged 18 and older with a thoracic aorta diameter greater than 4 cm. Mutation rates were compared by ACC/AHA testing criteria met by patients: age under 60, syndromic features of connective tissue diseases (CTD), family history, or none. Results were classified as pathogenic, variants of uncertain significance (VUS) or negative...

OBJECTIVES: Hypothermic lung preservation at 10°C has recently shown to enhance quality of healthy donor lungs during ischemia. This study aims to show generalizability of the 10°C lung preservation using an endotoxin-induced lung injury with specific focus on the benefits of post-transplant lung function and mitochondrial preservation. METHODS: Lipopolysaccharide (3 mg/kg) was injected intratracheally in rats to induce lung injury. Injured lungs were flushed with preservation solution and allocated to 3 groups (n = 6 each): minimum cold storage, 6-hour storage on ice (Ice), and 6-hour storage at 10°C (10C)...

OBJECTIVES: We previously reported that concurrent tricuspid valve surgery (TVS) was not associated with a lower incidence of early RHF among patients undergoing durable LVAD implantation. This is a follow-up analysis to further define the clinical impact of concurrent TVS within 12-months of follow-up. METHODS: Patients with moderate or severe TR on pre-operative echocardiography (n=71) were randomized to either LVAD implantation alone (No TVS, n=34) or with concurrent TVS (TVS, n=37)...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

OBJECTIVES: The ALINA trial introduced anaplastic lymphoma kinase (ALK) inhibitors in an early-stage context, generating notable interest. This study aims to investigate the characteristics and prognostic implications of ALK rearrangement in patients with resected lung adenocarcinoma (LUAD). METHODS: We retrospectively evaluated resected LUAD cases with documented ALK status from 2008 to 2020. The association between ALK positivity and clinicopathological characteristics, molecular profiles, and outcomes was explored...

BACKGROUND: Marfan syndrome (MFS) guidelines recommend optimal pharmacological therapy (OPT) and replacement of the ascending aorta (RAA) at 5.0cm diameters to prevent acute type A aortic dissection (ATAAD) and death. The effect of early MFS diagnosis and initiation of therapy on outcomes is not known. OBJECTIVE: To evaluate the effect of age at MFS diagnosis and therapy initiation on delayed RAA and death. METHODS: This retrospective observational cohort study with long-term follow-up included consecutive patients with MFS, pathogenic FBN1 variant, and regular visits to a European Reference Network Center...

OBJECTIVE: Develop and validate an interpretable machine learning model to predict one-year mortality in Type A aortic dissection (TAAD) patients, improving risk classification and aiding clinical decision-making. METHODS: We enrolled 289 TAAD patients, dividing them into a training cohort (202 patients) and a validation cohort (87 patients). The LASSO method with ten-fold cross-validation identified eight key factors related to one-year mortality. The Treebag model's performance was assessed using accuracy, F1-Score ,Brier score ,AUC and AUC-PR with calibration and clinical utility evaluated through decision curves...

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No abstract text is available yet for this article.

OBJECTIVE: Data on graded complications and their frequency after laparoscopic revisional antireflux and hiatal hernia surgery compared to primary surgery are lacking. We describe 30- and 90-day morbidity using the Clavien-Dindo (CD) classification. METHODS: 298 patients underwent revision surgery between 2003-2020 and were propensity matched to primary surgeries [1:2 ratio] based on age, sex, BMI, ASA classification, LA grade esophagitis, presence of Barrett's, and indication for surgery...

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OBJECTIVES: The task of writing structured content reviews and guidelines has grown stronger and more complex. We propose to go beyond search tools, toward curation tools, by automating time-consuming and repetitive steps of extracting and organizing information. METHODS: SciScribe is built as an extension of IBM's Deep Search platform, which provides document processing and search capabilities. This platform was used to ingest and search full-content publications from PubMed Central (PMC) and official, structured records from the ClinicalTrials and OpenPayments databases...

BACKGROUND: Single ventricle palliation (SVP) may be performed in patients with congenitally corrected transposition of the great arteries (ccTGA) due to either hypoplasia of one ventricle, or anatomic complexity rendering biventricular repair unfeasible. There have been only a few, small studies of the outcomes of SVP in the setting of ccTGA. METHODS: A multicentre, international, retrospective cohort study of patients with ccTGA undergoing SVP was conducted in 29 tertiary hospitals in 6 countries from 1990 to 2018...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

OBJECTIVE: Donation after circulatory death (DCD) heart transplantation potentially increases donor allografts, especially for patients with lower listing status. We assessed outcomes of DCD heart transplantation in patients bridged with durable left ventricular assist devices (LVAD). METHODS: The United Network for Organ Sharing (UNOS) database was queried for adult heart transplants utilizing DCD donors from 2019-2022. Patients were stratified between those with durable LVAD versus those with intra-aortic balloon pump, inotropic, or no bridging support (control group)...

OBJECTIVE: The necessity of mediastinal lymph node dissection (MLND) in segmentectomy remains uncertain as recent trials on intentional segmentectomy have made MLND mandatory. We conducted a retrospective study to evaluate the necessity of MLND in segmentectomy for patients with peripheral stage IA (≤2 cm) non-small-cell lung cancer (NSCLC). METHODS: Of the 5,222 surgical cases for NSCLC from three institutions between 2010 and 2021, 1,457 patients met the JCOG0802 trial eligibility criteria...

OBJECTIVES: The Ross procedure has excellent outcomes in the pediatric population. Some series report age and anatomy dependent outcomes, but no comprehensive analysis stratified by these variables exists. We sought to describe the landscape of congenital heart disease (CHD) treated with the Ross procedure and identify the patients best served with this operation. METHODS: Over 30 years, 317 pediatric patients underwent the Ross procedure. Patients were stratified into 4 age groups: neonates (<31days,n=21), infants (31days-1year,n=40), children (1-12years,n=165), and adolescents (13-18years,n=91), and 3 anatomical groups: isolated aortic valve (AV) disease (n=221), Shone's complex or multilevel LVOT obstruction (n=61), and complex CHD (n=35)...