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Journal of Surgical Research

Satomi Shiba, Atsushi Miki, Hideyuki Ohzawa, Takumi Teratani, Yasunaru Sakuma, Alan Kawarai Lefor, Joji Kitayama, Naohiro Sata
OBJECTIVE: Mucin1 (MUC1), a member of the mucin family, is a glycoprotein which is often expressed in malignant cells. However, the expression and function of MUC1 in human duodenal adenocarcinoma (DAC) has not yet been characterized because of its low frequency. Here, we examined the functional roles of core protein (MUC1-C) in DAC. MATERIALS AND METHODS: Using a human duodenal cancer cell line, HuTu80, proliferation, migration, invasion, ALDH activity was assessed by cell counting kit-8, scratch wound healing, matrigel invasion, and ALDEFUOR assays, respectively...
February 11, 2019: Journal of Surgical Research
Esteban Aguayo, Robert Lyons, Yas Sanaiha, Peyman Benharash
No abstract text is available yet for this article.
February 8, 2019: Journal of Surgical Research
Yuhki Koike, Keiichi Uchida, Mikihiro Inoue, Kohei Matsushita, Yoshiki Okita, Yuji Toiyama, Toshimitsu Araki, Masato Kusunoki
BACKGROUND: The predictive factors for the development of pouchitis after ileal pouch-anal anastomosis (IPAA) in pediatric-onset ulcerative colitis (UC) have not been well investigated. The present study aimed to determine the predictive factors for the development of pouchitis after IPAA in the pediatric UC population. METHODS: The data from 54 patients with pediatric-onset UC who underwent IPAA in Mie University Hospital between 2000 and 2017 were retrospectively reviewed...
February 8, 2019: Journal of Surgical Research
Anna Rose Johnson, Andres F Doval, Melisa D Granoff, Sabine A Egeler, Miguel G Bravo, A Samandar Dowlatshahi, Samuel J Lin, Bernard T Lee
BACKGROUND: Spanish-speaking Hispanics living in the United States utilize the internet as a primary means to obtain health information. Accurate, accessible information is important for English speakers; however, it could have even greater utility for Spanish speakers who have lower health literacy levels. The aim of this study was to evaluate and compare online English and Spanish carpal tunnel surgery materials provided by using a multimetric approach. MATERIALS AND METHODS: A web search using the English term "carpal tunnel surgery" was performed...
February 7, 2019: Journal of Surgical Research
Benjamin Nelson, Kim Na Eun, Brandy Sullivan, Patrick O'Neal, Vivian Sanchez, Edward Whang, Gentian Kristo
BACKGROUND: The present study was designed to implement and evaluate an interprofessional surgical technologist-to-surgical resident training program for junior general surgery residents aimed at enhancing their operating room skills. This program would be incorporated into the general surgery educational curriculum. MATERIAL AND METHODS: Under the guidance and supervision of a surgical technologist, first-year and second-year general surgery residents performed the perioperative and intraoperative tasks that are the responsibilities of the surgical technologist for 16 inguinal/umbilical hernia and 15 laparoscopic appendectomy/cholecystectomy operations performed by attending surgeons assisted by other surgical residents from June 01, 2017 until December 31, 2017...
February 6, 2019: Journal of Surgical Research
Greg J Zahner, Joel L Ramirez, Kimberly A Spaulding, Sukaynah A Khetani, Warren J Gasper, Carl Grunfeld, Nancy K Hills, Anne L Schafer, S Marlene Grenon
BACKGROUND: Leptin, adiponectin, and resistin are in a class of hormones called adipokines that are produced by adipocytes and have been implicated in the causal pathway of atherosclerosis. We examined the association between adipokine levels and peripheral artery disease (PAD), hypothesizing that after adjusting for fat mass, leptin and resistin would be higher, whereas adiponectin would be lower, in patients with PAD. METHODS: A cross-sectional sample of 179 predominately male (97%) vascular surgery outpatients was recruited from the San Francisco Veterans Affairs Medical Center (SFVAMC)...
February 6, 2019: Journal of Surgical Research
Patrick B Schwartz, Jeffrey J Easler, William P Lancaster, Michael G House, Nicholas J Zyromski, C Max Schmidt, Attila Nakeeb, Eugene P Ceppa
BACKGROUND: Management of Sphincter of Oddi Dysfunction (SOD) requires advanced techniques (endoscopic retrograde cholangiopancreatography via gastrostomy [GERCP]) after Roux-en-Y gastric bypass (RYGB) for obesity. Transduodenal sphincteroplasty (TS) is also performed yet carries the risks of surgery. We hypothesized that TS would have increased morbidity and mortality but provide a more durable remission of symptoms. METHODS: All patients between 2005 and 2016 with RYGB for obesity undergoing endoscopic or surgical management for type I or II SOD were included in the study...
February 6, 2019: Journal of Surgical Research
Zachary Zihui Yong, Grace Tan Hwei Ching, Melissa Teo Ching Ching
BACKGROUND: Mutant KRAS tumors are purported to metastasize differently than wild-type KRAS tumors. The biological heterogeneity of tumors from different parts of the colon are also reported to affect metastasis. This study aims to characterize the metastatic profile by evaluating these factors in unison. METHODS: Retrospective analysis of 899 patients with metastatic colorectal cancers treated from January 2010 to December 2014 was conducted. KRAS mutation status and primary tumors location were correlated with single-site metastasis (liver, lung, and peritoneum) and dual-site metastases (liver-peritoneum, liver-lung, and lung-peritoneum)...
February 5, 2019: Journal of Surgical Research
Tyler J Jones, Amy E Murphy, Ashley Tameron, Lala R Hussain, Kevin Grannan, Hamza Guend, Erik M Dunki-Jacobs, David Y Lee
BACKGROUND: Previous studies using the NSQIP database to study hepatectomies lacked hepatic specific variables and outcomes. We used the targeted NSQIP hepatectomy database to examine the nationwide trend and the safety profile of synchronous liver and colorectal resection compared with hepatectomy alone for colorectal liver metastasis. METHODS: The targeted NSQIP hepatectomy database from 2014 was used to study patients who underwent hepatectomy for diagnosis of adenocarcinoma of the colon and rectum...
February 5, 2019: Journal of Surgical Research
Muhammad Ali Chaudhary, Arvind von Keudell, Nizar Bhulani, Elzerie C de Jager, Nicollette K Kwon, Tracey Koehlmoos, Adil H Haider, Andrew J Schoenfeld
BACKGROUND: Prior opioid use has been shown to be associated with adverse outcomes in surgical and trauma patients. We sought to evaluate the influence of prior opioid use on prescription opioid requirements after orthopedic trauma. MATERIALS AND METHODS: This was a retrospective review of TRICARE claims (2006-2014). We evaluated the records of 11,752 patients treated for orthopedic injuries. Surveillance for prior opioid exposure extended to 6 mo before the traumatic event, with similar postinjury surveillance...
February 5, 2019: Journal of Surgical Research
Emily G Heywood, Thomas M Drake, Mike Bradburn, Justin Lee, Matthew J Wilson, Matthew J Lee
BACKGROUND: Atrial fibrillation (AF) is a common dysrhythmia that can occur after major physiological stress including surgery (postoperative AF). There are few data on postoperative AF after abdominal surgery. We set out to define the incidence of de novo postoperative AF after abdominal surgery and associated risk factors. METHODS: The Patient History Integrated Data store administrative database was interrogated for patients aged ≥65 y undergoing abdominal surgery from April 2012 to April 2014...
February 5, 2019: Journal of Surgical Research
Chasen J Greig, Lucy Zhang, Sarah J Armenia, Christine J Park, Anne C Fischer, Michael G Caty, Robert A Cowles
BACKGROUND: Abstracts presented at the American Academy of Pediatrics Section on Surgery (AAP) and American Pediatric Surgical Association (APSA) meetings can be taken as a reasonable representation of academic activity in pediatric surgery. We sought to assess ongoing trends in pediatric surgical research by analyzing the scientific content of each association's yearly meeting. METHODS: Abstracts presented at AAP and APSA between 2009 and 2013 were identified from the final printed programs (n = 910)...
February 2, 2019: Journal of Surgical Research
Luis F Acosta, Roberto Galuppo, Catherine R García, Evelyn Villacorta, Adam Dugan, Ana Lía Castellanos, Roberto Gedaly, James T Lee
BACKGROUND: Sarcopenia is one of the most common complications of cirrhosis. Liver transplantation (LT) is the treatment of choice for patients with early-stage hepatocellular carcinoma (HCC) that are unsuitable for resection. METHODS: We performed a retrospective analysis of 163 patients transplanted at our institution with HCC from 1998 to 2016. Sarcopenia was diagnosed based on the skeletal muscle mass on computed tomography imaging using SliceOmatic 5.0 software at L3 level (≤52...
February 2, 2019: Journal of Surgical Research
Frank Dewaele, Tim De Pauw, Alain Kalmar, Piet Pattyn, Isabelle Van Herzeele, Alexandre Mottrie, Yves Van Nieuwenhove, Dirk Van Roost
BACKGROUND: Conventional rigid laparoscopic instruments offer five degrees of freedom (DOF). Robotic instruments add two independent DOFs allowing unconstrained directional steering. Several nonrobotic instruments have been developed with the additional DOFs, but with these devices, surgeon's wrist movements are not intuitively transmitted into tip movements. In this study, a new articulated instrument has been evaluated. The aim of the study was to compare learning curves and performances of conventional laparoscopic instruments, the da Vinci system and Steerable devices in a crossover study...
February 2, 2019: Journal of Surgical Research
Lauren L Traill
No abstract text is available yet for this article.
January 31, 2019: Journal of Surgical Research
Marc Miserez, An P Jairam, Geesien S A Boersema, Yves Bayon, Johannes Jeekel, Johan F Lange
BACKGROUND: Prosthetic materials for the repair of abdominal wall defects have been studied extensively to improve outcome. A new approach can be the use of a slowly resorbable synthetic mesh, which aims to combine advantages of both synthetic and biological meshes. The objective of this review is to give an overview of the physicochemical characteristics and biomechanical, histological, and macroscopic outcome (recurrence, adhesion formation) of the use of resorbable synthetic meshes, for treatment and prevention of abdominal wall hernias, based on experimental studies...
January 30, 2019: Journal of Surgical Research
Nora Bismar, Ashish S Patel, David T Schindel
BACKGROUND: Younger children are referred for surgical intervention in the treatment of ulcerative colitis (UC) and familial adenomatous polyposis (FAP). Outcome data in this population after a laparoscopic restorative proctocolectomy and Ileal pouch-anal anastomosis (LRS-IPAA) are limited. We reviewed our experience to determine if younger children would have similar functional outcomes. METHODS: After institutional review board approval, a review of children with FAP and UC undergoing LRS-IPAA at a children's hospital from 2002 to 2017 occurred...
January 30, 2019: Journal of Surgical Research
Tarek Ezzat Abdel-Aziz, Fergus Gleeson, Greg Sadler, Radu Mihai
BACKGROUD: This study compares the outcome of parathyroidectomy for primary hyperparathyroidism (PHPT) in patients whose adenomas' weights were at the extremes of the distribution curve. As the size of parathyroid adenomas influences the success rate of localization studies for PHPT, it is possible that a difference in cure rate could be observed between subgroups of patients. MATERIALS AND METHODS: Data were retrieved from a prospective database maintained in a large university hospital...
January 25, 2019: Journal of Surgical Research
Joanna W Etra, Caitlin W Hicks, Michol A Cooper, Margaret Arnold, Thomas Reifsnyder
BACKGROUND: We describe the feasibility and long-term outcomes of using femoral vein (FV) for arteriovenous fistula (AVF) and lower extremity bypass (LEB) creation. METHODS: All patients undergoing AVF or LEB using autogenous FV by a single surgeon (April 2006 to September 2013) were reviewed. Perioperative (30-d) complications and long-term outcomes are described. RESULTS: Forty-four patients underwent vascular reconstruction with FV (AVF = 27 and LEB = 17)...
January 24, 2019: Journal of Surgical Research
Yvonne H Sada, Brandon G Smaglo, Hop S Tran Cao, Henry Mok, Benjamin L Musher, Nader N Massarweh
BACKGROUND: Multimodality therapy (MMT) is recommended for patients with resectable gastric cancer, but no single approach has been established as standard. Little is presently known about current national practice patterns and sequencing of MMT. METHODS: Retrospective cohort study of patients with gastric cancer aged 18 to 80 y in the National Cancer Database (2006-2014) with ≥T2 and/or node-positive disease (i.e., stage Ib to III) treated with MMT. Clinical nodal staging accuracy was ascertained among those treated with upfront surgery by comparing clinical and pathologic nodal staging...
January 23, 2019: Journal of Surgical Research
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