Keizo Kaku, Shinsuke Kubo, Yu Sato, Takanori Mei, Hiroshi Noguchi, Yasuhiro Okabe, Masafumi Nakamura
INTRODUCTION: Bench surgery for the preparation of deceased donor pancreatic grafts is labor-intensive and time-consuming. We hypothesized that energy devices could be used during bench surgery to decrease the bench surgery time. However, because bench surgery has two unique characteristics, wet conditions and no blood flow in the vessels, it is necessary to verify the safety and efficacy under such conditions. METHODS: In an animal tissue model, we validated both ultrasonic and bipolar energy devices: Harmonic Shears and the LigaSure (LS) vessel-sealing device by evaluating heat spread and pressure resistance under bench surgery conditions...
April 11, 2024: Journal of Surgical Research
Loïc Van Dieren, Pierre Tawa, Marie Coppens, Laura Naenen, Omer Dogan, Tom Quisenaerts, Hyshem H Lancia, Haïzam Oubari, Yohann Dabi, Maxime De Fré, Filip Thiessen Ef, Curtis L Cetrulo, Alexandre G Lellouch
INTRODUCTION: Vascularized Composite Allografts (VCA) are usually performed in a full major histocompatibility complex mismatch setting, with a risk of acute rejection depending on factors such as the type of immunosuppression therapy and the quality of graft preservation. In this systematic review, we present the different immunosuppression protocols used in VCA and point out relationships between acute rejection rates and possible factors that might influence it. METHODS: This systematic review was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines...
April 10, 2024: Journal of Surgical Research
Lakshika Tennakoon, Ara Ko, Ariel W Knight, Aussama K Nassar, Ruoxue Wu, David A Spain, Lisa M Knowlton
INTRODUCTION: There has been a sharp climb in the Unites States' death rate among opioid and other substance abuse patients, as well as an increased prevalence in gun violence. We aimed to investigate the association between substance abuse and gun violence in a national sample of patients presenting to US emergency departments (EDs). METHODS: We queried the 2018-2019 Nationwide Emergency Department Sample for patients ≥18 years with substance abuse disorders (opioid and other) using International Classification of Diseases, 10th Revision, Clinical Modification codes...
April 10, 2024: Journal of Surgical Research
Lia Michos, Gregory L Whitehorn, Mark Seamon, Jeremy W Cannon, Jay Yelon, Patrick Kim, Justin S Hatchimonji, Jamie Song, Elinore J Kaufman
INTRODUCTION: Organized trauma systems reduce morbidity and mortality after serious injury. Rapid transport to high-level trauma centers is ideal, but not always feasible. Thus, interhospital transfers are an important component of trauma systems. However, transferring a seriously injured patient carries the risk of worsening condition before reaching definitive care. In this study, we evaluated characteristics and outcomes of patients whose hemodynamic status worsened during the transfer process...
April 10, 2024: Journal of Surgical Research
Liliane Moreira Ruiz, Karina Andrighetti de Oliveira Braga, Natalia Aparecida Nepomuceno, Aristides Tadeu Correia, Guilherme Henrique Ribeiro de Carvalho, Vanessa Sana Vilela, Marisa Dolhnikoff, Paulo Manuel Pêgo-Fernandes
INTRODUCTION: Brain death (BD) compromises the viability of the lung for donation. Hypertonic saline solution (HSS) induces rapid intravascular volume expansion and immunomodulatory action. We investigated its role in ventilatory mechanics (VMs) and in the inflammatory activity of the lungs of rats subjected to BD. METHODS: Wistar rats were divided into four groups: control, n = 10: intact rats subjected to extraction of the heart-lung block; BD, n = 8 (BD): rats treated with isotonic saline solution (4 mL/kg) immediately after BD; hypertonic saline 0 h, n = 9 (Hip...
April 10, 2024: Journal of Surgical Research
Harrison D Davis, Theodore E Habarth-Morales, Charles A Messa, Robyn B Broach, Ines C Lin
INTRODUCTION: Extracorporeal membrane oxygenation (ECMO)-associated compartment syndrome (CS) is a rare complication seen in critically ill patients. The epidemiology and management of ECMO-associated CS in the upper extremity (UE) and lower extremity (LE) are poorly defined in the literature. We sought to determine the epidemiology and characterize treatment and outcomes of UE-CS compared to LE-CS in the setting of ECMO therapy. METHODS: Adult patients undergoing ECMO therapy were identified in the Nationwide Readmission Database (2015-2019) and followed up for 6 months...
April 8, 2024: Journal of Surgical Research
Sara Abou Azar, Lee Stratton, Kelvin Memeh, Rachel Nordgren, Edwin L Kaplan, Peter Angelos, Xavier M Keutgen
INTRODUCTION: Elevated metanephrine and catecholamine levels 3-fold upper limit of normal (ULN) are diagnostic for pheochromocytoma. We sought to determine whether size correlates with biochemical activity or symptoms which could guide timing of surgery. METHODS: Data from consecutive patients undergoing adrenalectomy for pheochromocytoma at our institution over a 10-year period were retrospectively collected. These included maximal lesion diameter on preoperative imaging, plasma/urine metanephrine and/or catecholamine levels, demographic variables and presence of typical paroxysmal symptoms...
April 8, 2024: Journal of Surgical Research
Héctor Capella-Monsonís, Arthi Shridhar, Bharadwaj Chirravuri, Matthew Figucia, Greg Learn, Keith Greenawalt, Stephen F Badylak
No abstract text is available yet for this article.
April 8, 2024: Journal of Surgical Research
Kyle Harris, Anthony Brusnahan, Samantha Shugar, Jason Miner
INTRODUCTION: Approximately 75% of traumatic brain injuries (TBIs) qualify as mild. However, there exists no universally agreed upon definition for mild TBI (mTBI). Consequently, treatment guidelines for this group are lacking. The Center for Disease Control (CDC), American College of Rehabilitation Medicine (ACRM), Veterans Affairs and Department of Defense (VA/DoD), Eastern Association for the Surgery of Trauma (EAST), and the University of Arizona's Brain Injury Guidelines (BIG) have each published differing definitions for mTBI...
April 8, 2024: Journal of Surgical Research
Stephanie L Rakestraw, Adam T Lucy, Lauren N Wood, Daniel I Chu, Jayleen Grams, Richard Stahl, Margaux N Mustian
INTRODUCTION: Enhanced Recovery Programs (ERPs) mitigate racial disparities in postoperative length of stay (LOS) for colorectal populations. It is unclear, however, if these effects exist in the bariatric surgery population. Therefore, this study aimed to evaluate the racial disparities in LOS before and after implementation of bariatric surgery ERP. METHODS: A retrospective cohort study was performed using data from a single institution. Patients undergoing minimally invasive sleeve gastrectomy or Roux-en-Y gastric bypass from 2017 to 2019 (pre-ERP) or 2020-2022 (ERP) were included...
April 5, 2024: Journal of Surgical Research
Colleen P Nofi, Bailey K Roberts, Michelle P Kallis, Donna Koo, Richard D Glick, Barrie S Rich
INTRODUCTION: Cervical lymphadenopathy in children is typically self-limited; however, the management of persistent lymphadenopathy remains unclear. This study aimed to evaluate the management and outcomes of patients with persistent cervical lymphadenopathy. METHODS: Single-institution, retrospective review of children <18 years undergoing ultrasound (US) for cervical lymphadenopathy from 2013 to 2021 was performed. Patients were stratified into initial biopsy, delayed biopsy, or no biopsy groups...
April 5, 2024: Journal of Surgical Research
Can Jin, Yongtao Wu, Zhiyi Wang, Xiaoran Liu, Qiang Wang
INTRODUCTION: Isolated partial anomalous pulmonary venous connection (PAPVC) is difficult to diagnose, and surgical indications remain controversial. We reviewed 10 y of isolated PAPVC cases. METHODS: The data of patients with isolated PAPVC admitted to the Anzhen Congenital Heart Disease Department from 2010 to 2019 were reviewed retrospectively. RESULTS: Thirty patients, aged between 4 mo and 32 y, were included in this study...
April 3, 2024: Journal of Surgical Research
Sai Krishna Bhogadi, Khaled El-Qawaqzeh, Christina Colosimo, Hamidreza Hosseinpour, Louis J Magnotti, Audrey L Spencer, Tanya Anand, Michael Ditillo, Qaidar Alizai, Adam Nelson, Bellal Joseph
INTRODUCTION: There is a paucity of large-scale data on the factors that suggest an impending or underlying extremity pediatric acute compartment syndrome (ACS). In addition, literature regarding the timing of operative fixation and the risk of ACS is mixed. We aimed to describe the factors associated with pediatric ACS. METHODS: Analysis of 2017-2019 Trauma Quality Improvement Program. We included patients aged <18 y diagnosed with upper extremity (UE) and lower extremity (LE) fractures...
April 2, 2024: Journal of Surgical Research
Tasce Bongiovanni, Siqi Gan, Emily Finlayson, Joseph S Ross, James D Harrison, W John Boscardin, Michael A Steinman
BACKGROUND: Disparities in opioid prescribing by race/ethnicity have been described in many healthcare settings, with White patients being more likely to receive an opioid prescription than other races studied. As surgeons increase prescribing of nonopioid medications in response to the opioid epidemic, it is unknown whether postoperative prescribing disparities also exist for these medications, specifically gabapentinoids. METHODS: We conducted a retrospective cohort study using a 20% Medicare sample for 2013-2018...
March 29, 2024: Journal of Surgical Research
Daniela Maria Gomez Zubieta, Eman Mubarak, Kathryn Messner, Gifty Kwakye
INTRODUCTION: An intestinal stoma creation is one of the most common surgical procedures. Despite benefits, a stoma can have serious effects on a patient's quality of life. Multiple dimensions of everyday life can be affected such as social life, body image, as well as ability to participate in some religious practices, with some faith groups being disproportionately affected. This study sought to understand the extent to which faith is addressed during these sessions given the integral role it plays for some patients...
March 28, 2024: Journal of Surgical Research
Collin Pilkington, Tarendeep Thind, Stephen M Bowman, Kevin Sexton, Mary Katherine Kimbrough, Austin Porter, Ben Davis, Judy Bennett, Avi Bhavaraju, Hanna K Jensen
INTRODUCTION: Readmissions after a traumatic brain injury (TBI) can have severe impacts on long-term health outcomes as well as rehabilitation. The aim of this descriptive study was to analyze the Nationwide Readmissions Database to determine possible risk factors associated with readmission for patients who previously sustained a TBI. METHODS: This retrospective study used data from the Nationwide Readmissions Database to explore gender, age, injury severity score, comorbidities, index admission hospital size, discharge disposition of the patient, and cause for readmission for adults admitted with a TBI...
March 28, 2024: Journal of Surgical Research
Joseph C L'Huillier, Kabir Jalal, Eden Nohra, Joseph D Boccardo, Olatoyosi Olafuyi, Marcy Bubar Jordan, Ajay A Myneni, Steven D Schwaitzberg, William J Flynn, Jeffrey J Brewer, Katia Noyes, Clairice A Cooper
INTRODUCTION: Survival following emergency department thoracotomy (EDT) for patients in extremis is poor. Whether intervention in the operating room instead of EDT in select patients could lead to improved outcomes is unknown. We hypothesized that patients who underwent intervention in the operating room would have improved outcomes compared to those who underwent EDT. METHODS: We conducted a retrospective review of the Trauma Quality Improvement Program database from 2017 to 2021...
March 28, 2024: Journal of Surgical Research
Jana E Dejesus, Xiaofu Wang, Yanping Gu, Jia Zhou, Ravi S Radhakrishnan
INTRODUCTION: Activated hepatic stellate cells (HSCs) are the primary effector cells in hepatic fibrosis, over depositing extracellular matrix (ECM) proteins. Our previous work found oridonin analog CYD0682 attenuates proliferation, Transforming Growth Factor β (TGFβ)-induced signaling, and ECM production in immortalized HSCs. The underlying mechanism behind these reductions is unclear. The Signal Transduction and Activator of Transcription 3 (STAT3) pathway plays a central role in HSC activation and has been found to be overexpressed in models of hepatic injury...
March 26, 2024: Journal of Surgical Research
Meridiana Mendez, Kurt Panganiban, Kathleen Kieran
INTRODUCTION: Understanding who accompanies children to clinic visits is necessary to engage stakeholders and tailor communication and educational materials. We undertook this study to describe the clinical companions for new patients in a general pediatric urology clinic. METHODS: This retrospective cross-sectional study included all new urology patients aged less than 18 y at a single freestanding quaternary care children's hospital in selected months of 2019 and 2022...
March 25, 2024: Journal of Surgical Research
Dillon J Wade, Collin Pilkington, J Curran Henson, Hanna K Jensen, Kyle Kalkwarf, Avi Bhavaraju, Nolan Bruce, Stephen Bowman, Joseph Margolick
INTRODUCTION: Calcium is required for coagulation, cardiac output, and peripheral vascular resistance. Between 85% and 94% of trauma patients treated with massive blood transfusion develop hypocalcemia.1 The aim of this study is to evaluate the relationship between increased intravenous calcium administration during massive transfusion and improved survival of trauma patients. METHODS: We performed a retrospective analysis of trauma patients who received massive transfusion over a 2-y period...
March 21, 2024: Journal of Surgical Research
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