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Journal of Surgical Oncology

Kota Sahara, Diamantis I Tsilimigras, Rittal Mehta, Fabio Bagante, Alfredo Guglielmi, Luca Aldrighetti, Sorin Alexandrescu, Hugo P Marques, Feng Shen, Bas G Koerkamp, Itaru Endo, Timothy M Pawlik
BACKGROUND: The aim of the current study was to develop an online calculator to predict survival after liver resection for intrahepatic cholangiocarcinoma (ICC) based on the "metro-ticket" paradigm. METHODS: Between 1990 and 2016, patients who underwent liver resection for ICC were identified in an international multi-institutional database. The final multivariable model of survival was used to develop an online prognostic calculator of survival. RESULTS: Among 643 patients, actual 5-year overall survival (OS) after resection for ICC was 42...
April 19, 2019: Journal of Surgical Oncology
Fabian M Johnston, Michael Beckman
Breaking bad news and navigating difficult conversations is challenging and a frequent occurrence in surgical oncology practice. Cancer communication recommendations are guided by ethical principles, legal precedence, and emerging evidence regarding patient preference and efficacy of communication tools. Evidence continues to mount supporting a patient-centered communication approach and a model of shared decision making. Likewise, physician training in effective patient-centered cancer communication continues to evolve...
April 18, 2019: Journal of Surgical Oncology
Xu-Feng Zhang, Alexandra G Lopez-Aguiar, George Poultsides, Eleftherios Makris, Flavio Rocha, Zaheer Kanji, Sharon Weber, Ryan Fields, Bradley A Krasnick, Kamran Idrees, Paula M Smith, Cliff Cho, Carl R Schmidt, Shishir K Maithel, Timothy M Pawlik
BACKGROUND: To determine short- and long-term oncologic outcomes after minimally invasive distal pancreatectomy (MIDP) with open distal pancreatectomy (ODP) for the treatment of pancreatic neuroendocrine tumor (pNET). METHODS: The data of the patients who underwent curative MIDP or ODP for pNET between 2000 and 2016 were collected from a multi-institutional database. Propensity score matching (PSM) was used to generate 1:1 matched patients with MIDP and ODP. RESULTS: A total of 576 patients undergoing curative DP for pNET were included...
April 18, 2019: Journal of Surgical Oncology
Thomas D Dobbs, Thomas H Jovic, Zita Jessop, Iain S Whitaker
No abstract text is available yet for this article.
April 17, 2019: Journal of Surgical Oncology
Karin M Hardiman, Alexis G Antunez, Arielle Kanters, Ari D Schuman, Scott E Regenbogen
BACKGROUND AND OBJECTIVES: In North America, preoperative combination chemoradiation is the most commonly recommended and utilized approach to locally advanced rectal cancer. There is increasing interest in the use of induction chemotherapy (IC) before radiation and surgery in locally advanced rectal cancer. How widely IC is being used and whether it improves pathologic and oncologic outcomes is unknown. METHODS: We evaluated clinical stage 2 or 3 rectal cancer patients in the National Cancer Database between 2006 and 2015...
April 16, 2019: Journal of Surgical Oncology
Ivana Petrovic, Zain U Ahmed, Ashley Hay, Evan B Rosen, Chuanyong Lu, Meera Hameed, Jatin P Shah
INTRODUCTION: Sarcomas of the mandible are extremely rare tumors, with osteosarcoma being the most common, followed by Ewing's sarcoma MATERIALS AND METHODS: A retrospective review of the clinical records, imaging studies, and pathology slides of patients with sarcoma of the mandible at a Tertiary Care Cancer Center from 1998 to 2014 was undertaken. The impact of neoadjuvant chemotherapy and postoperative radiotherapy with or without chemotherapy was studied, and factors impacting upon local control and disease-specific survival were analyzed...
April 16, 2019: Journal of Surgical Oncology
Simona Simonidesova, Eva Hamsikova, Viera Ludvikova, Jan Klozar, Ondrej Vencalek, Ruth Tachezy
BACKGROUND: The presence of human papillomavirus (HPV)-specific antibodies in patients with head and neck cancer at enrollment has prognostic significance. In cervical carcinoma patients, the decrease of HPV E6/E7-specific antibodies appears to be associated with a better prognosis. METHODS: This prospective study with follow-up focused on the persistence and prognostic value of antibodies specific for HR HPV-derived VLPs and HPV16 E6/E7 oncoproteins in patients with oropharyngeal cancers...
April 15, 2019: Journal of Surgical Oncology
Alicia A Gingrich, Sarah B Bateni, Arta M Monjazeb, Steven W Thorpe, Amanda R Kirane, Richard J Bold, Robert J Canter
BACKGROUND: As the U.S. population ages, differences in oncologic outcomes among the elderly have been recognized. Our objective was to analyze the clinical, pathologic, and treatment outcomes for elderly soft tissue sarcoma (STS) patients, hypothesizing significant differences in the management and response to therapy. METHODS: Using the National Cancer Database, we identified 33 859 patients with nonmetastatic extremity STS. We defined elderly as ≥74 years in age and compared patient and treatment variables between adult and elderly patients...
April 12, 2019: Journal of Surgical Oncology
Ahsun Riaz, John P Pinkard, Riad Salem, Robert J Lewandowski
Percutaneous biliary interventions have established their role in the management of benign and malignant biliary disease. There are limited data comparing procedures performed by gastroenterologists and interventional radiologists in managing malignant biliary obstruction. Endoscopic procedures performed by gastroenterologists are not completely benign with reported complications ranging from 2% to 15%. It is important that gastroenterologists and interventional radiologists collaborate to form algorithms for management of malignant biliary obstruction which provide safe and efficacious care to these patients...
April 12, 2019: Journal of Surgical Oncology
Pia Antony, Julian C Harnoss, Rene Warschkow, Bruno M Schmied, Martin Schneider, Ignazio Tarantino, Alexis Ulrich
BACKGROUND AND OBJECTIVES: Despite advances in early detection of colon cancer, a minority of patients still require urgent surgery. Whether such urgent conditions result in poor outcome remains a topic of debate. METHODS: Using a prospectively maintained database, patients suffering exclusively from colon cancer and receiving either elective or emergent resection between 2001 and 2014 were analyzed with respect to overall, disease-specific, and relative survival using Cox regression and propensity score analyses...
April 12, 2019: Journal of Surgical Oncology
Ryan J Ellis, D Brock Hewitt, Jason B Liu, Mark E Cohen, Ryan P Merkow, David J Bentrem, Karl Y Bilimoria, Anthony D Yang
BACKGROUND: Pancreatic fistula remains common, with limited ability to risk stratify patients preoperatively. The objective of this study was to identify risk factors for clinically-relevant postoperative pancreatic fistula (CR-POPF) that are routinely available in the preoperative setting. METHODS: Preoperatively available variables for all pancreaticoduodenectomies from 2014-2017 were examined using a national clinical registry. The cohort was separated into risk factor identification and internal validation subgroups...
April 5, 2019: Journal of Surgical Oncology
Kimberley S Samkoe, Hira S Sardar, Brent D Bates, Niki N Tselepidakis, Jason R Gunn, Kevin A Hoffer-Hawlik, Joachim Feldwisch, Brian W Pogue, Keith D Paulsen, Eric R Henderson
BACKGROUND AND OBJECTIVES: Fluorescence-guided surgery using epidermal growth factor receptor (EGFR) targeting has been performed successfully in clinical trials using a variety of fluorescent agents. We investigate ABY-029 (anti-EGFR Affibody® molecule labeled with IRDye 800CW) compared with a small-molecule perfusion agent, IRDye 700DX carboxylate, in a panel of soft-tissue sarcomas with varying levels of EGFR expression and vascularization. METHODS: Five xenograft soft-tissue sarcoma cell lines were implanted into immunosuppressed mice...
April 4, 2019: Journal of Surgical Oncology
Arif Chaudhry, Jeremie D Oliver, Krishna S Vyas, Saad A Alsubaie, Oscar J Manrique, Jorys Martinez-Jorge
BACKGROUND: The Goldilocks mastectomy procedure involves local contouring of completely autologous breast tissue created by preserving and de-epithelializing the residual mastectomy flaps. The purpose of this study was to provide outcomes data for 96-Goldilocks mastectomy procedures analyzing indications, complications, relevant comorbidities, and adjuvant cancer treatment impacting reconstructive and aesthetic outcomes. METHODS: Comprehensive review of every patient who underwent Goldilocks mastectomy from 2012 to 2018 included relevant medical and surgical comorbidities, as well as complication profiles...
April 4, 2019: Journal of Surgical Oncology
Susan D McCammon
Head and neck cancer affects vital functions of speech, swallowing, breathing, and appearance. Overall survival remains poor and symptom burden is high for both patients with incurable disease at the end of life and for long-term survivors. Early and concurrent palliative care helps guide treatment decision making and support quality of life during and after treatment. Both narrative competence and directive counsel can affect the concordance of patient goals and tolerance of treatment and outcomes.
March 29, 2019: Journal of Surgical Oncology
Jae Kwang Yun, Geun Dong Lee, Hyeong Ryul Kim, Dong Kwan Kim, Jae Il Zo, Young Mog Shim, Chang Hyun Kang, Young Tae Kim, Hyo Chae Paik, Kyoung Young Chung
OBJECTIVES: This study aimed to compare the predictive ability between the Masaoka-Koga (M-K) staging system and the 8th TNM staging system for the recurrence of thymic epithelial tumors (TETs). In addition, a nomogram was developed on the basis of the proposed TNM classification to predict individual recurrence rate. METHODS: A retrospective study was performed on 445 patients who underwent complete resection (R0) of TETs between January 2000 and February 2013...
March 28, 2019: Journal of Surgical Oncology
Michel D Wissing, Fabiano Santos, Ahmed S Zakaria, Ana O'Flaherty, Simon Tanguay, Wassim Kassouf, Armen G Aprikian
BACKGROUND AND OBJECTIVES: We evaluated the short- and long-term outcome in bladder cancer (BC) patients treated with radical cystectomy (RC) in Québec (Canada). METHODS: Data were collected from provincial registries on all BC patients who underwent RC in Québec province in 2000-2015. Outcomes were hospitalization rates and survival. Survival analyses were conducted using log-rank tests and Cox proportional hazards models. RESULTS: In total, 4450 patients were included in our analysis...
March 28, 2019: Journal of Surgical Oncology
Nicholas Alexakis, Konstandinos Bramis, Konstandinos Toutouzas, George Zografos, Manoussos Konstadoulakis
BACKGROUND/AIM: Anatomic vascular abnormalities of the hepatic arteries are frequent. The aim of the study was to analyze the influence of hepatic arterial variations on postoperative morbidity and resection margin status after pancreatoduodenectomy (PD). MATERIALS/METHODS: Patients who underwent PD over a 7-year period (2010-2017) were included in the study. Patients with variant hepatic arterial anatomy were matched 1:2 for age, sex, ASA score, and histology. RESULTS: A total of 232 patients underwent PD...
March 28, 2019: Journal of Surgical Oncology
Bridget N Fahy
Palliative care (PC) seeks to improve the quality of life for patients facing serious illness. Several oncology organizations have guidelines about PC, reflecting the need to integrate PC into standard oncology care. Many surgical patients do not receive PC despite the need for these services and established surgical PC competencies. Recent educational and research efforts reveal increased appreciation of the need and benefit of integrating PC services with cancer care in general, and surgical care, specifically...
March 28, 2019: Journal of Surgical Oncology
Darren Plummer, Edward Passen, John Alexander, Sravya Vajapey, Travis Frantz, Steven Niedermeier, Robert Pettit, Thomas Scharschmidt
BACKGROUND AND OBJECTIVES: Large acetabular defects secondary to metastatic disease frequently require extensive acetabular reconstruction. Techniques of acetabular reconstruction have been described, but no consensus for the management of these defects has been reached so far. We present our technique and patient outcomes for acetabular reconstruction by cementing a dual mobility cup into an acetabular cage. METHODS: We reviewed 152 total hip arthroplasties and identified 19 patients with periacetabular metastatic disease and large defects who required acetabular reconstruction utilizing a dual mobility cup cemented into an acetabular reconstructive cage...
March 25, 2019: Journal of Surgical Oncology
Fei Wang, Yi-Lin Hu, Ying Feng, Yi-Bing Guo, Yi-Fei Liu, Qin-Sheng Mao, Wan-Jiang Xue
BACKGROUND AND OBJECTIVES: Serine protease-3 (PRSS3) is a known contributor to the genesis and development of malignant tumors, although its role in gastric cancer (GC) is still unclear. METHODS: PRSS3 expression in GC tissue samples and its relationship with clinicopathological features were analyzed. Effects of GC cellular responses to the introduction of small interfering RNA (siRNA)-mediated and short hairpin RNA (shRNA)-mediated interference with tumor PRSS3 expression were also assessed...
March 25, 2019: Journal of Surgical Oncology
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