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Journal of Sexual Medicine

Giorgio Ivan Russo, Giovanni Cacciamani, Andrea Cocci, Thomas M Kessler, Giuseppe Morgia, Ege Can Serefoglu, Maarten Albersen, Paolo Verze
INTRODUCTION: Medical treatment of Peyronie's disease (PD) in terms of intralesional therapy is still a matter of debate. AIM: To compare the efficacy of different classes of intralesional therapy with a network meta-analysis (NMA) method. METHODS: The search was conducted using documents published in PubMed, Scopus, and Web of Science databases until September 30, 2017. We included randomized controlled trials comparing at least 1 intralesional therapy with a placebo therapy or with another drug for the treatment of PD...
January 25, 2019: Journal of Sexual Medicine
Adam S Baumgarten, Jonathan A Beilan, Bhavik B Shah, Aram Loeb, Michael Bickell, Justin Parker, Gerard D Henry, Rafael E Carrion
INTRODUCTION: Many men suffering from erectile dysfunction are overweight with generous suprapubic fat pads, which often contribute to a decrease in visible exophytic phallic length. AIM: To present a novel surgical concept of suprapubic fat pad excision with a concomitant placement of inflatable penile prosthesis. METHODS: A transverse incision begins slightly medial to the anterior superior iliac spine, with the superior edge crossing transversely to the contralateral anterior superior iliac spine...
January 25, 2019: Journal of Sexual Medicine
Shankun Zhao, Jiamin Wang, Qiang Xie, Lianmin Luo, Zhiguo Zhu, Yangzhou Liu, Yihan Deng, Ran Kang, Jintai Luo, Zhigang Zhao
INTRODUCTION: Exposure to air pollution poses a risk for morbidity in multiple diseases. However, the role of ambient air pollutant emissions in public sexual health is just beginning to be understood and remains controversial. AIM: We have determined to elucidate the specific role of gasoline vehicle exhaust (VE), a crucial source and toxicant of air pollution, in the penile erectile function via a rat model. METHODS: 40 male Sprague Dawley rats, 12 weeks of age, were used in this experiment...
January 25, 2019: Journal of Sexual Medicine
Dennis H Li, Thomas A Remble, Kathryn Macapagal, Brian Mustanski
INTRODUCTION: Sexual function and satisfaction are understudied aspects of adolescent and young adult sexual wellbeing, and even less is known about sexual minority youth who are vulnerable to unique lesbian, gay, bisexual, and transgender (LGBT)-related stigma. AIM: We aimed to describe sexual functioning (sexual interest, erectile function, orgasm satisfaction, global satisfaction with one's sex life, and anal discomfort) and examine its associations with demographics, sexual and relationship behavior, and minority stressors (internalized stigma, victimization, microaggressions, and perceived LGBT acceptance within residential neighborhood) among a cohort of young men who have sex with men (YMSM) aged 16-29...
January 21, 2019: Journal of Sexual Medicine
Mark J Kiss, Todd G Morrison, Lorraine K McDonagh
INTRODUCTION: An expanding area of research within the realm of body image is its role in human sexual functioning, which denotes people's overall satisfaction with their performance during a specific sexual encounter. Traditionally, studies investigating the association between body image and sexual functioning have focused on women. The Male Body Image Self-Consciousness Scale (M-BISC) was developed to exclusively assess male body image self-consciousness during sexual activity using a sample consisting primarily of heterosexual men...
January 14, 2019: Journal of Sexual Medicine
Capri G Foy, Jill C Newman, Dan R Berlowitz, Laurie P Russell, Paul L Kimmel, Virginia G Wadley, Holly N Thomas, Alan J Lerner, William T Riley
INTRODUCTION: Erectile function, an important aspect of quality of life, is gaining increased research and clinical attention in older men with hypertension. AIM: To assess the cross-sectional association between blood pressure measures (systolic blood pressure [SBP]; diastolic blood pressure [DBP]; and pulse pressure [PP]) and (i) sexual activity and (ii) erectile function in hypertensive men. METHODS: We performed analyses of 1,255 male participants in a larger randomized clinical trial of 9,361 men and women with hypertension aged ≥50 years...
January 14, 2019: Journal of Sexual Medicine
Frederikke Louise Wammen Rathenborg, Bozena Zdaniuk, Lori A Brotto
INTRODUCTION: Studies of pain measurement in women with provoked vestibulodynia (PVD) use various methods of capturing pain intensity. The degree to which these different measures of pain correspond with one another is not known. AIM: To compare 3 different measures of pain intensity in sexually active women with PVD participating in a clinical treatment study. METHODS: A total of 64 women (mean age 30.9 years) provided baseline measures of pain intensity using (i) a numeric rating scale that provided a self-report of pain during recalled vaginal penetration; (ii) the pain subscale of the female sexual function index; and (iii) pain elicited with a vulvalgesiometer, an objective method of eliciting pain...
January 14, 2019: Journal of Sexual Medicine
Paul Neuville, Nicolas Morel-Journel, Delphine Cabelguenne, Alain Ruffion, Philippe Paparel, Jean-Etienne Terrier
INTRODUCTION: The ZSI 475FtM is a new prosthesis that has recently been specifically designed for phalloplasty. It has several functions that have been conceived to answer the challenges of implantation after phalloplasty: a large base for pubic bone fixation, realistically shaped hard glans, and a pump shaped like a testicle. AIM: To assess the safety, feasibility, and patient satisfaction of the ZSI 475 FtM. METHODS: Surgical outcomes were analyzed after implantation of the prosthesis between June 2016 and September 2017 (single institution, single surgeon)...
January 9, 2019: Journal of Sexual Medicine
Gary J Muirhead, Ian H Osterloh, Steven Whaley, Frans van den Berg
BACKGROUND: Cligosiban (formerly IX-01) is a selective oxytocin receptor antagonist being developed for the treatment of premature ejaculation (PE). AIM: To investigate the plasma pharmacokinetics, safety, and tolerability of multiple oral doses of cligosiban in healthy male subjects; measure the amount of cligosiban in semen; and evaluate the potential of cligosiban to modulate CYP3A4. METHODS: Both studies were double-blind, placebo-controlled, parallel group designs involving sequential cohorts of 12 subjects each...
January 4, 2019: Journal of Sexual Medicine
Jonathan Clavell-Hernández, Samuel G Aly, Run Wang, Hossein Sadeghi-Nejad
BACKGROUND: Removal of the penile prosthesis reservoir can be technically challenging because of its difficult locations either deep in the pelvis or high in the abdominal wall. AIM: To describe a detailed surgical technique for reservoir removal through a penoscrotal approach. METHODS: We describe our preferred method for removal of prosthetic reservoir and present a retrospective review of patient outcomes after reservoir removal. MAIN OUTCOME MEASURE: Primary outcomes included immediate or late complications...
December 11, 2018: Journal of Sexual Medicine
Hsun Shuan Wang, Yajun Ruan, Lia Banie, Kai Cui, Ning Kang, Dongyi Peng, Tianshu Liu, Tianyu Wang, Bohan Wang, Guifang Wang, Alan W Shindel, Guiting Lin, Tom F Lue
BACKGROUND: Erectile dysfunction (ED) caused by pelvic neurovascular injury (PNVI) is often refractory to treatment. In many cases, erectogenic therapy is administered in a delayed fashion. AIM: To evaluate penile hemodynamic effects and histologic changes associated with delayed low-intensity extracorporeal shock wave therapy (Li-ESWT) after PNVI ED in a rat model. We visualized images using immunofluorescence and 3-dimensional imaging of solvent-cleared organs (3DISCO), a novel imaging technique...
November 30, 2018: Journal of Sexual Medicine
R Hart Moore, Uzoma A Anele, Sarah C Krzastek, Adam P Klausner, J Tyler Roseman
BACKGROUND: Despite the known nephrotoxicity of gentamicin, in 2008 the American Urological Association recommended a weight-based gentamicin dose of 5 mg/kg for antimicrobial prophylaxis during urologic prosthetic surgery. AIM: To identify and characterize rates of acute kidney injury (AKI) in urologic prosthetic surgery, both before and after the implementation of weight-based gentamicin dosing. METHODS: We performed a single-institution retrospective study of patients receiving perioperative gentamicin during implant, revision, salvage, or explant of inflatable penile prostheses, malleable penile prostheses, or artificial urinary sphincters between the years 2000 and 2017...
November 30, 2018: Journal of Sexual Medicine
Natalie O Rosen, Justin P Dubé, Serena Corsini-Munt, Amy Muise
INTRODUCTION: Women diagnosed with female sexual interest/arousal disorder (FSIAD) report lower health-related quality of life, more depressive symptoms, and lower sexual and relationship satisfaction compared with healthy control subjects. Despite the impact of FSIAD on women's sexuality and the inherently interpersonal nature of the sexual problem, it remains unclear whether the partners of women with FSIAD also face negative consequences, as seen in other sexual dysfunctions. AIM: The aim of this study was to compare the sexual, relational, and psychological functioning of partners of women with FSIAD (as well as the women themselves) to their control counterparts...
November 30, 2018: Journal of Sexual Medicine
Thierry Almont, Anne-Déborah Bouhnik, Ali Ben Charif, Marc-Karim Bendiane, Corinne Couteau, Cécile Manceau, Julien Mancini, Éric Huyghe
BACKGROUND: Colorectal cancer (CRC) is accompanied by specific treatment-related physical (ostomy, incontinence) and psychosexual (body image, depression) consequences on sexual health. AIM: To assess sexual health of patients with CRC 2 years after diagnosis. METHODS: We selected all patients with CRC from a French nationwide longitudinal study. Data sources included patient questionnaires, medical questionnaires, and medico-administrative databases...
January 2019: Journal of Sexual Medicine
Xincai Zhou, Fengdi Cao, Zhengshen Lin, Donglei Wu
INTRODUCTION: The relationship between periodontal disease (PD) and erectile dysfunction (ED) is still conflicting. AIM: To investigate whether a link between PD and ED exists, and if so, the degree to which it is significant. METHODS: The search strategy included using electronic databases and hand searching works published up to June 2018. MEDLINE via PubMed, EMBASE, Proceedings Web of Science, and Current Contents Connect were searched by 2 independent reviewers...
January 2019: Journal of Sexual Medicine
Liat Ayalon, Ateret Gewirtz-Meydan, Inbar Levkovich
INTRODUCTION: Research has consistently documented changes in sexual functioning as people age. AIM: To examine the ways older men and women cope with changes in sexual functioning. METHODS: In-depth interviews with 47 Israelis over the age of 60 were conducted and analyzed thematically. MAIN OUTCOME MEASURE: The main outcomes of interest in this study were the coping strategies employed by older men and women to address changes in their sexuality...
January 2019: Journal of Sexual Medicine
Dong Sup Lee, Jin Bong Choi, Dong Wan Sohn
INTRODUCTION: It is unclear how sleep deprivation (SD) exerts a negative effect on men's health in terms of hypogonadism. AIM: To evaluate the hypothalamic-pituitary-gonadal (HPG) axis in subjects with SD and ultimately to evaluate the erectile tissue in response to the hormonal changes. METHODS: 56 male Wistar rats were used. First, 16 rats (16 weeks old) were subjected to 72 hours of SD, and the following were compared with 16 control rats: (i) levels of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T), and cortisol; (ii) the expression of the kisspeptin mRNA in the brain; and (iii) assessment of immunohistochemistry (IHC) of brain and testis...
January 2019: Journal of Sexual Medicine
Michelle D Vaughan, Peyton Jones, B Adam Taylor, Jessica Roush
BACKGROUND: Individuals engaged in consensual non-monogamy (CNM) face broad and potentially harmful experiences of sexual stigma in society, yet no published empirical literature has examined the experiences of this population within the healthcare system. AIM: The present investigation sought to explore positive and negative experiences of CNM individuals within the healthcare system, as well as specific needs of these patients regarding inclusive healthcare practices...
January 2019: Journal of Sexual Medicine
Shelby A Powers, Michael R Odom, Elena S Pak, Megan A Moomaw, Kathleen A Ashcraft, Bridget F Koontz, Johanna L Hannan
BACKGROUND: Erectile dysfunction (ED) is common following radiation therapy (RT) for prostate cancer. Although the cause of RT-induced ED is unknown, damage to both the neuronal and vascular components supporting erections are often implicated. AIM: To determine the effects of prostatic RT on erections, penile vascular physiology, and major pelvic ganglia (MPG) neuron growth and survival in a rat model. METHODS: Male rats underwent 0 Gy or 22 Gy single fraction of prostate-confined, conformal RT...
January 2019: Journal of Sexual Medicine
Christian C Joyal, Christian Kärgel, Jonas Kneer, Till Amelung, Sebastian Mohnke, Gilian Tenbergen, Henrik Walter, Tillman H C Kruger
No abstract text is available yet for this article.
January 2019: Journal of Sexual Medicine
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