journal
https://read.qxmd.com/read/38521973/immunohistochemical-staining-with-cd117-and-pgp9-5-of-excised-vestibular-tissue-from-patients-with-neuroproliferative-vestibulodynia
#1
JOURNAL ARTICLE
Alexandra Drian, Sue W Goldstein, Noel N Kim, Andrew S Goldstein, Rose Hartzell-Cushanick, Alyssa Yee, Irwin Goldstein
BACKGROUND: Neuroproliferative vestibulodynia (NPV), a provoked genital pain characterized by severe allodynia and hyperalgesia, is confirmed in excised vestibular tissue by immunohistochemical staining (>8 CD117-positive immunostained cells/100× microscopic field) rather than by hematoxylin and eosin staining. AIM: In this study we sought to assess immunostaining of tissue samples obtained during vestibulectomy surgery and to correlate results with patient outcomes...
March 23, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38515327/efficacy-of-in-office-lysis-of-clitoral-adhesions-with-excision-of-keratin-pearls-on-clitoral-pain-and-sexual-function-a-pre-post-interventional-study
#2
JOURNAL ARTICLE
Jill M Krapf, Isabella Kopits, Jessica Holloway, Sylvia Lorenzini, Theodora Mautz, Andrew T Goldstein
BACKGROUND: Keratin pearls are foci of central keratinization within concentric layers of squamous cells that can form under the clitoral prepuce and cause pain (clitorodynia); in-office removal of keratin pearls may reduce clitoral pain and improve sexual function. AIM: This study aims to investigate clitoral pain and sexual function in women with partial clitoral phimosis and keratin pearls before and after in-office lysis of clitoral adhesions with keratin pearl excision (LCA-KPE)...
March 21, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38515322/development-of-a-core-outcome-set-for-treatment-studies-for-provoked-vestibulodynia
#3
JOURNAL ARTICLE
Nina Bohm-Starke, Caroline Pukall, Marie Österberg, Maria Ahlberg, Ann Kristine Jonsson, Sofia Tranæus, Susanna Kempe, Christel Hellberg
BACKGROUND: There is an inconsistency in treatment outcomes used in clinical trials for provoked vestibulodynia (PVD), which makes it impossible to compare the effects of different interventions. AIM: In this study, we completed the first step in creating a core outcome set (COS), defining what outcomes should be measured in clinical trials for PVD. METHODS: Identification of outcomes used in studies was done by extracting data from clinical trials in a recently published systematic review and via review of clinical trials for PVD registered on ClinicalTrials...
March 21, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38515245/psychosexological-correlates-of-372-women-with-vulvodynia-overactive-pelvic-floor-postcoital-cystitis-and-interstitial-cystitis
#4
JOURNAL ARTICLE
Noemi Ricucci, Elena Colonnello, Erika Limoncin, Daniele Mollaioli, Andrea Sansone, Emmanuele A Jannini, Giacomo Ciocca
BACKGROUND: Among the plethora of urogynecological conditions possibly affecting women, some of them, less explored, have significant impacts on sexological and psychological health, with a mutual influence. AIM: The aim of this study was to investigate the sexological and psychological correlates of four urogynecological pathologies in a sample of women of childbearing age: overactive pelvic floor, vulvodynia, postcoital cystitis, and interstitial cystitis. Women cured of these conditions were also included, to assess the same aspects after the remission of physical symptoms...
March 21, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38508858/treatment-of-women-with-vaginal-laxity-systematic-review-with-meta-analysis
#5
JOURNAL ARTICLE
Glaucia Miranda Varella Pereira, Rufus Cartwright, Cássia Raquel Teatin Juliato, Claudine Domoney, Cheryl B Iglesia, Luiz Gustavo Oliveira Brito
BACKGROUND: Despite several treatments that have been used for women reporting vaginal laxity (VL), to our knowledge no systematic review is available on the topic so far. AIM: In this study, we sought to summarize the best available evidence about the efficacy and safety of interventions for treating VL, whether conservative or surgical. METHODS: A comprehensive search strategy was performed in Medline, Embase, Scopus, Web of Science, and Cochrane Library for reports of clinical trials published from database inception to September 2022...
March 20, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38501193/genital-self-image-and-sexual-function-in-iranian-women-from-pregnancy-to-postpartum-a-cohort-study
#6
JOURNAL ARTICLE
Ghazale Samiei, Zahra Mehrbakhsh, Hamideh Khosravi, Sedigheh Moghasemi
BACKGROUND: Genital self-image is among the factors affecting women's sexual function. AIM: The present study aimed to determine changes in the genital self-image and its relationship with women's sexual function in the third trimester of pregnancy and postpartum. METHODS: The participants of this prospective cohort study included 301 eligible pregnant women chosen through stratified random sampling with proportional allocation from comprehensive health centers in Gorgan, Iran...
March 18, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38491395/-i-think-my-vagina-is-still-there-women-s-perspectives-on-sexual-function-and-dysfunction-following-radical-cystectomy-for-bladder-cancer-a-qualitative-study
#7
JOURNAL ARTICLE
Rachel Carmen Ceasar, Seyedeh-Sanam Ladi-Seyedian, Domenique Escobar, Jullet Han, Kailyn Koh, Sima Porten, Carissa Chu, Erin E Gould, Sumeet Bhanvadia
BACKGROUND: Women's sexual health after radical cystectomy is an important but poorly understood aspect of bladder cancer survivorship. Dedicated investigation is needed to elucidate patient perceptions on sexual function and dysfunction in this setting. AIMS: In this study we sought to qualitatively examine women's perceptions and experiences of sexual health following radical cystectomy for bladder cancer. METHODS: We conducted one-on-one qualitative telephone interviews with 40 women who underwent radical cystectomy in the past 6 months to 5 years and signed a research consent form to be contacted for future studies...
March 15, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38490973/biopsychosocial-determinants-of-sexual-health-in-older-age-the-role-of-health-related-relationship-and-psychosexual-factors
#8
JOURNAL ARTICLE
Priscila A Vasconcelos, Constança Paúl, Pedro J Nobre
BACKGROUND: Given the unprecedented aging of the population and the increased focus on overall well-being in older age, investigating the determining factors of sexual well-being in older adults becomes essential as it offers insights into promoting healthy aging and overall quality of life. AIM: By applying the biopsychosocial model of sexuality in older age, we aimed to identify the role of biomedical and psychosocial factors in predicting sexual well-being in partnered older adults (≥55 years old)...
March 15, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38481019/analysis-of-diurnal-variation-in-serum-testosterone-levels-in-men-with-symptoms-of-testosterone-deficiency
#9
JOURNAL ARTICLE
Luis F Novaes, Jose M Flores, Nicole Benfante, Elizabeth Schofield, Darren J Katz, Chris J Nelson, John P Mulhall
BACKGROUND: Testosterone (T) plays a crucial role in various physiological functions in men, and understanding the variations in T levels during the day is essential for diagnosing and treating testosterone deficiency (TD). AIM: We sought to evaluate the reduction in serum total T (TT) levels throughout the day in men with symptoms of testosterone deficiency and to determine the variables having an impact on the extent of this decline. METHODS: The study population consisted of a group of men who within 3 months of each other had all undergone both early morning and afternoon TT level measurements...
March 13, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38481017/does-climate-impact-inflatable-penile-prosthesis-infection-ipp-risk-assessment-of-temperature-and-dew-point-on-ipp-infections
#10
JOURNAL ARTICLE
David W Barham, Nikolaos Pyrgidis, Eliad Amini, Muhammed Hammad, Jake Miller, Robert Andrianne, Arthur L Burnett, Kelli Gross, Georgios Hatzichristodoulou, James Hotaling, Tung-Chin Hsieh, Lawrence C Jenkins, James M Jones, Aaron Lentz, Vaibhav Modgil, Daniar Osmonov, Sung Hun Park, Ian Pearce, Paul Perito, Hossein Sadeghi-Nejad, Maxime Sempels, Alfredo Suarez-Sarmiento, Jay Simhan, Koenraad van Renterghem, J Nicholas Warner, Matthew Ziegelmann, Faysal A Yafi, Martin S Gross
BACKGROUND: Variations in climate have been associated with a greater risk of surgical site infections, urinary tract infections, and changes in the skin microbiome; however, limited data exist on the impact of climate on inflatable penile prosthesis (IPP) infections. AIM: We sought to evaluate the impact of climate on the risk of IPP infections in a large international, multicenter cohort. METHODS: We performed a multi-institutional, retrospective study of patients undergoing IPP surgery...
March 13, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38481013/parental-concerns-about-genital-differences-in-children-with-congenital-adrenal-hyperplasia-persist-regardless-of-the-selected-intervention
#11
JOURNAL ARTICLE
Julie Alderson, Maia Thornton, Mars Skae, Julie Jones, Nicky Nicoll, Diana Harcourt, Mark Woodward, Elizabeth C Crowne
BACKGROUND: Congenital Adrenal Hyperplasia (CAH) due to 21-hydroxylase deficiency (21HD) can affect the in utero development of the genital anatomy of people with the 46XX karyotype. Health professionals engage parents in decision-making regarding managing genitals with this difference, including genital surgery options and patient communication. AIM: We sought to investigate parental communication with their daughters regarding clitoral size variation related to neonatal CAH...
March 13, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38477106/development-and-validation-of-3-dimensional-simulators-for-penile-prosthesis-surgery
#12
JOURNAL ARTICLE
Yacov Reisman, Koen van Renterghem, Boaz Meijer, Anna Ricapito, Mikkel Fode, Carlo Bettocchi
BACKGROUND: The acquisition of skills in penile prosthesis surgery has many limitations mainly due to the absence of simulators and models for training. Three-dimensional (3D) printed models can be utilized for surgical simulations, as they provide an opportunity to practice before entering the operating room and provide better understanding of the surgical approach. AIM: This study aimed to evaluate and validate a 3D model of human male genitalia for penile prosthesis surgery...
March 13, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38477100/cldn4-overexpression-promotes-penile-cavernous-smooth-muscle-cell-fibrotic-response-via-the-jnk-signaling-pathway
#13
JOURNAL ARTICLE
Huang Jie, Wang Jie, Guo Yingxue, Zhang Xin, Xu Runnan, Huang Wenjie, Ma Jianxiong, Lv Bodong
BACKGROUND: Erectile dysfunction (ED), defined as the inability to achieve or maintain a penile erection sufficient to satisfy sexual behavior, is prevalent worldwide. AIM: Using previous research, bioinformatics, and experimental confirmation, we aimed to discover genes that contribute to ED through regulating hypoxia in corpus cavernosum smooth muscle cells (CCSMCs). METHODS: We used the Gene Expression Omnibus to acquire the sequencing data of the corpus cavernosum transcriptome for diabetic ED and nerve injury type ED rats...
March 13, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38465848/a-randomized-comparison-of-online-mindfulness-based-group-sex-therapy-vs-supportive-group-sex-education-to-address-sexual-dysfunction-in-breast-cancer-survivors
#14
JOURNAL ARTICLE
Lori A Brotto, Lauren Walker, Carly Sears, Shannon Woo, Roanne Millman, Bozena Zdaniuk
BACKGROUND: Sexual difficulties and vaginal pain are common following treatment for breast cancer. AIM: The goal of this study was to evaluate an online mindfulness-based group sex therapy vs an online supportive sex education group therapy to address these sexual difficulties. METHODS: Breast cancer survivors (n = 118) were randomized to 1 of the 2 arms; 116 provided informed consent and completed the time 1 assessment. Treatment included 8 weekly 2-hour online group sessions...
March 11, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38459625/testosterone-therapy-in-females-is-not-associated-with-increased-cardiovascular-or-breast-cancer-risk-a-claims-database-analysis
#15
JOURNAL ARTICLE
Pranjal Agrawal, Sajya M Singh, Jessica Hsueh, Aurora Grutman, Clemens An, Corey Able, Una Choi, Jaden Kohn, Marisa Clifton, Taylor P Kohn
BACKGROUND: Testosterone therapy (TTh) has been shown to improve libido in women with sexual dysfunction, but its utilization has been limited due to concern for cardiovascular events and past studies reporting highly variable results. AIM: To assess the association of TTh in women with major adverse cardiac events (MACEs), including heart attack, stroke, or death, using a large database. METHODS: The TriNetX Diamond Network was queried from 2009 to 2022...
March 8, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38451321/shh-regulates-penile-morphology-and-smooth-muscle-through-a-mechanism-involving-bmp4-and-grem1
#16
JOURNAL ARTICLE
Jiangping Deng, Sarah Martin, Timothy Searl, Samuel Ohlander, Daniel A Harrington, Kevin T McVary, Carol A Podlasek
BACKGROUND: The cavernous nerve (CN) is frequently damaged in prostatectomy and diabetic patients with erectile dysfunction (ED), initiating changes in penile morphology including an acute and intense phase of apoptosis in penile smooth muscle and increased collagen, which alter penile architecture and make corpora cavernosa smooth muscle less able to relax in response to neurotransmitters, resulting in ED. AIM: Sonic hedgehog (SHH) is a critical regulator of penile smooth muscle, and SHH treatment suppresses penile remodeling after CN injury through an unknown mechanism; we examine if part of the mechanism of how SHH preserves smooth muscle after CN injury involves bone morphogenetic protein 4 (BMP4) and gremlin1 (GREM1)...
March 6, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38451311/bmp4-and-grem1-are-targets-of-shh-signaling-and-downstream-regulators-of-collagen-in-the-penis
#17
JOURNAL ARTICLE
Jiangping Deng, Timothy Searl, Samuel Ohlander, Danuta Dynda, Daniel A Harrington, Kevin T McVary, Carol A Podlasek
BACKGROUND: Cavernous nerve (CN) injury, caused by prostatectomy and diabetes, initiates a remodeling process (smooth muscle apoptosis and increased collagen) in the corpora cavernosa of the penis of patients and animal models that is an underlying cause of erectile dysfunction (ED), and the Sonic hedgehog (SHH) pathway plays an essential role in the response of the penis to denervation, as collagen increases with SHH inhibition and decreases with SHH treatment. AIM: We examined if part of the mechanism of how SHH prevents penile remodeling and increased collagen with CN injury involves bone morphogenetic protein 4 (BMP4) and gremlin1 (GREM1) and examined the relationship between SHH, BMP4, GREM1, and collagen in penis of ED patients and rat models of CN injury, SHH inhibition, and SHH, BMP4, and GREM1 treatment...
March 6, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38441523/commentary-on-characteristics-of-systemic-testosterone-therapy-for-female-hypoactive-sexual-desire-disorder-a-claims-database-analysis
#18
JOURNAL ARTICLE
Javier Angulo
No abstract text is available yet for this article.
March 5, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38441522/double-longitudinal-myotomy-in-gender-affirming-colovaginoplasty-an-innovative-surgical-technique-to-prevent-and-treat-neovaginal-spasms
#19
JOURNAL ARTICLE
Iván Mañero Vazquez, Trinidad Labanca, Roberto Herrero
BACKGROUND: Gender-affirming colovaginoplasty (GACv) presents excellent postoperative results. However, neovaginal spasms, reported as painful cramps, can affect the sexual life of patients. AIM: The study sought to describe an innovative surgical technique and evaluate its impact on the prevention and treatment of neovaginal spasms. METHODS: This was a single-center prospective observational study with 2 series of patients: (1) patients who underwent GACv with double myotomy (DM) for spasm prevention (series A), in which longitudinal myotomies were performed across the defunctionalized colon, transecting the taenias, and resecting 2 strips of the intestinal muscle layer of approximately 1- to 2-mm wide and tall, leaving intact colonic tissue between strips; and (2) patients who reported neovaginal spasms in whom intravaginal-DM was performed as treatment surgery (series B), in which the posterior wall of the neovagina was dissected from the rectum and transected by longitudinal myotomies, resecting 2 strips of endoluminal mucosa and submucosal muscle of approximately 1- to 2-mm wide and tall, and the colonic mucosa was subsequently closed...
March 5, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38441520/characteristics-of-systemic-testosterone-therapy-for-female-hypoactive-sexual-desire-disorder-a-claims-database-analysis
#20
JOURNAL ARTICLE
Pranjal Agrawal, Yeonsoo Sara Lee, Aurora J Grutman, Kathryn Dumas, Taylor Kohn, Jaden Kohn, Alyssa M Yee, Marisa Clifton
BACKGROUND: Testosterone therapy (TTh) is recommended for postmenopausal women with hypoactive sexual desire disorder (HSDD); however, there remain insufficient data to support use of TTh in premenopausal women with sexual dysfunction. AIM: In this study, we used a large national database to evaluate prescribing trends of TTh for women with HSDD. METHODS: We conducted a cohort analysis of information from electronic health records acquired from the data network TriNetX Diamond...
March 5, 2024: Journal of Sexual Medicine
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