Jiasen He, Miriam B Garcia, Jeremy S Connors, Cesar A Nuñez, Andres E Quesada, Amber Gibson, Michael Roth, Branko Cuglievan, Naveen Pemmaraju, David McCall
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy, especially in pediatrics, that can involve the bone marrow, skin, lymph nodes, and central nervous system (CNS). Given its variable clinical presentation, coupled with an immunohistochemistry pattern (CD4, CD56, TCF4, TCL-1, and CD123 positivity) that differs from other myeloid neoplasms, the diagnosis of BPDCN can be missed. Limited data are available to guide the treatment of pediatric BPDCN. Herein, we report a case of a pediatric patient who had BPDCN with central nervous system, orbital, and skin involvement...
September 4, 2023: Journal of Pediatric Hematology/oncology