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Journals Journal of Pediatric Gastroent...

Journal of Pediatric Gastroenterology and Nutrition

https://read.qxmd.com/read/38529852/parenteral-nutrition-emulsion-inhibits-cyp3a4-in-an-ipsc-derived-liver-organoids-testing-platform
#21
JOURNAL ARTICLE
Sean P Harrison, Saphira F Baumgarten, Maria E Chollet, Benedicte Stavik, Anindita Bhattacharya, Runar Almaas, Gareth J Sullivan
OBJECTIVES: Parenteral nutrition (PN) is used for patients of varying ages with intestinal failure to supplement calories. Premature newborns with low birth weight are at a high risk for developing PN associated liver disease (PNALD) including steatosis, cholestasis, and gallbladder sludge/stones. To optimize nutrition regimens, models are required to predict PNALD. METHODS: We have exploited induced pluripotent stem cell derived liver organoids to provide a testing platform for PNALD...
March 26, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38529849/paediatric-steatotic-liver-disease-has-unique-characteristics-%C3%A2-a-multisociety-statement-endorsing-the-new-nomenclature
#22
JOURNAL ARTICLE
Pietro Vajro
Nonalcoholic fatty liver disease (NAFLD) has been a commonly used term and diagnosis in paediatric hepatology, gastroenterology, and endocrinology clinics for over 30 years. A multisociety Delphi process has determined a new name "Steatotic Liver Disease" (SLD) as the overarching term for disorders associated with hepatic lipid accumulation. Our Societies give our support to steatotic liver disease as the best overarching term for use in our communities. Metabolic dysfunction-associated steatotic liver disease (MASLD) overcomes many of the shortcomings of the name NAFLD...
March 26, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38516909/pediatric-retrograde-cricopharyngeal-dysfunction-diagnosed-by-high-resolution%C3%A2-impedance-manometry
#23
JOURNAL ARTICLE
Lev Dorfman, Khalil El-Chammas, Sherief Mansi, Kahleb Graham, Ajay Kaul
OBJECTIVES: The inability to burp, known as retrograde cricopharyngeal dysfunction (R-CPD), was initially described in adults. The proposed clinical diagnostic criteria for R-CPD include belching inability, abdominal bloating and discomfort/nausea, postprandial chest pain, and involuntary noises. Botulinum toxin injection to the cricopharyngeal muscle has been reported to be beneficial. High-resolution esophageal impedance-manometry (HRIM) features in adolescent patients with R-CPD have not been described yet...
March 22, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38516908/meal-related-symptoms-in-youth-with-chronic-abdominal-pain-relationship-to-anxiety-depression-and-sleep-dysfunction
#24
JOURNAL ARTICLE
Achintya Benegal, Hunter Friesen, Jennifer Schurman, Jennifer Colombo, Craig Friesen
OBJECTIVE: The objective of the current study was to describe meal-related symptoms in youth with chronic abdominal pain fulfilling criteria for a disorder of gut-brain interaction (DGBI) and their associations with anxiety, depression, and sleep disturbances. METHODS: This was a retrospective evaluation of 226 consecutive patients diagnosed with an abdominal pain-associated DGBI. As part of routine care, all had completed a standardized symptom history, the Sleep Disturbances Scale for Children (utilized to assess for disorders of initiation and maintenance of sleep and excessive daytime somnolence) and the Behavior Assessment System for Children-Third Edition (utilized to assess for anxiety and depression)...
March 22, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38511559/prevalence-of-eosinophilic-gastrointestinal-diseases-in-children-with-short-bowel-syndrome-a-single-center-study
#25
JOURNAL ARTICLE
Nicole Du, Clarivet Torres
Patients with short bowel syndrome (SBS) have multiple risk factors for eosinophilic gastrointestinal diseases (EGIDs) including increased risk for intestinal dysbiosis and food allergy compared to their counterparts with normal anatomy. However, there is limited data on the prevalence of EGIDs in children with SBS. We aimed to define the prevalence of EGIDs in an SBS cohort and its association with different risk factors via a retrospective chart review of patients with SBS at Children's National Hospital...
March 21, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38506111/availability-and-utilization-of-endoscopic-retrograde-cholangiopancreatography-at-children-s-hospitals
#26
JOURNAL ARTICLE
Sagar J Pathak, Thomas Attard, Matthew Hall, Mustafa Arain, Melvin B Heyman, Emily R Perito
OBJECTIVES: No study has explored whether availability of endoscopic retrograde cholangiopancreatography (ERCP) is adequate and equitable across US children's hospitals. We hypothesized that ERCP availability and utilization differs by geography and patient factors. METHODS: Healthcare encounter data from 2009 to 2019 on children with pancreatic and biliary diseases from the Pediatric Health Information System were analyzed. ERCP availability was defined as treatment at a hospital that performed pediatric ERCP during the year of service...
March 20, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38497334/awareness-referral-and-age-at-kasai-surgery-for-biliary-atresia-in-europe-a-survey-of-the-quality-of-care-task-force-of-espghan
#27
JOURNAL ARTICLE
Florence Lacaille, Emanuele Nicastro, Piotr Czubkowski, Cristina Campos Gonçalves, Thu Giang Le Thi, Sibylle Koletzko
OBJECTIVES: To identify infants with biliary atresia (BA), European Society of Paediatric Gastroenteroloy and Nutrition (ESPGHAN)/North American Society of Pediatric Gastroenteroloy and Nutrition (NASPGHAN) guidelines recommend measurement of conjugated/direct bilirubin in infants with prolonged jaundice and using a stool colour card (SCC). The 'Quality of Care' Task Force of ESPGHAN performed two surveys to assess current case finding for BA and age at Kasai portoenterostomy (KPE)...
March 18, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38482943/endoscopic-and-histologic-utility-of-transnasal-endoscopy-in-pediatric-eosinophilic-esophagitis
#28
JOURNAL ARTICLE
Eliana Shaul, Kanak V Kennedy, Zachary C Spergel, Shanaz Daneshdoost, Mark Mahon, Shivani Thanawala, Jonathan M Spergel, Benjamin Wilkins, Matthew J Ryan, Amanda B Muir
Unsedated transnasal endoscopy (TNE) is an alternative method of examining the esophageal mucosa in pediatric patients with eosinophilic esophagitis (EoE), reducing cost, time, and risk associated with frequent surveillance esophagogastroduodenoscopies (EGD). Adequacy of transnasal esophageal biopsies for the evaluation of eosinophilic esophagitis histologic scoring system (EoEHSS) has not yet been evaluated. We compared procedure times, endoscopic findings, and EoEHSS scoring for EoE patients undergoing TNE versus standard EGD...
March 14, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38482890/real-world-effectiveness-of-ustekinumab-and-vedolizumab-in-tnf-exposed-pediatric-patients-with-ulcerative-colitis
#29
JOURNAL ARTICLE
Perseus V Patel, Amy Zhang, Balu Bhasuran, Vignesh G Ravindranath, Melvin B Heyman, Sofia G Verstraete, Atul J Butte, Michael J Rosen, Vivek A Rudrapatna
OBJECTIVES: Vedolizumab (VDZ) and ustekinumab (UST) are second-line treatments in pediatric patients with ulcerative colitis (UC) refractory to antitumor necrosis factor (anti-TNF) therapy. Pediatric studies comparing the effectiveness of these medications are lacking. Using a registry from ImproveCareNow (ICN), a global research network in pediatric inflammatory bowel disease, we compared the effectiveness of UST and VDZ in anti-TNF refractory UC. METHODS: We performed a propensity-score weighted regression analysis to compare corticosteroid-free clinical remission (CFCR) at 6 months from starting second-line therapy...
March 14, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38477410/combination-biologic-therapy-in-pediatric-inflammatory-bowel-disease-safety-and-efficacy-over-a-minimum-12-month-follow-up-period
#30
JOURNAL ARTICLE
Magdalena Wlazlo, Monika Meglicka, Anna Wiernicka, Marcin Osiecki, Malgorzata Matuszczyk, Jaroslaw Kierkus
OBJECTIVES: The severe course of inflammatory bowel diseases (IBDs) refractory to advanced therapies in children results in the search for new therapeutic methods. The aim of this study was to evaluate the efficacy and safety of dual therapy with biologics in a cohort of children with IBD. METHODS: Retrospective analysis of data from 29 children with a diagnosis of IBD, 19 with ulcerative colitis (66%), 10 with Crohn's disease (CD) (34%) qualified for dual biological therapy (DBT)...
March 13, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38477385/gluten-free-diet-adherence-in-pediatric-celiac-patients-evaluating-cdat-questionnaire-and-test-for-gluten-detection-in-urine
#31
JOURNAL ARTICLE
Carolina R Lins E Mello, Gisélia A P da Silva, Manuela T C Lins, Margarida M de C Antunes
OBJECTIVES: This study aimed to evaluate the contributions of the Adapted Celiac Dietary Adherence Test (CDAT) and the Rapid Urinary Gluten Detection Test (u-GIP) in assessing gluten-free diet adherence in children and adolescents with celiac disease. METHODS: Fifty-four celiac patients from two pediatric gastroenterology outpatient clinics affiliated with university hospitals were evaluated. The original CDAT was adapted for children through a transcultural process, and the original cutoff point was adopted to define adherence...
March 13, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38477384/measurement-practices-of-alanine-aminotransferase-in-children-temporal-changes-and-etiology-for-increased-values
#32
JOURNAL ARTICLE
Linnea Aitokari, Pauliina Hiltunen, Heini Huhtala, Kalle Kurppa, Laura Kivelä
Data on alanine aminotransferase (ALT) measurement practices and diagnoses associated with increased values are limited. We evaluated these issues by collecting ALT measurements from 1- to 16-year-old patients investigated in 1992-2018 in a tertiary center. Diagnoses were gathered in 2008-2018. Altogether 145,092 measurements from 28,118 children were taken 42% undergoing repeated testing. Testing increased from 21/1000 to 81/1000 children and the prevalence of elevated values fluctuated between 18% and 26%...
March 13, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38477364/shear-wave-elastography-for-monitoring-fontan-associated-liver-disease-a-prospective-cohort-study
#33
JOURNAL ARTICLE
Rishi Bolia, Sara Alremawi, Charlton Noble, Robert Justo, Cameron Ward, Peter J Lewindon
The spectrum of Fontan-associated liver disease (FALD) varies from abnormal liver function tests to fibrosis and even cirrhosis. In this prospective study, we evaluated the role of shear-wave elastography (SWE) in predicting the presence of advanced FALD. Forty-eight patients (30 males, 13.9 [6-21] years) with a Fontan circulation were evaluated at 8.3 (2.1-18.7) years since the Fontan surgery. The median liver stiffness measurement (LSM) value was higher than values in normal children at 15.4 (9.5-38.7) kPa...
March 13, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38477361/impact-of-covid-19-on-paediatric-chronic-intestinal-failure-a-tertiary-care-children-s-hospital-experience
#34
JOURNAL ARTICLE
Johannes Hilberath, Anna-Sophia Mast, Simon Scherer, Jörg Fuchs, Johannes Schulte, Ekkehard Sturm, Steven Warmann, Christoph Slavetinsky
OBJECTIVES: Paediatric patients with intestinal failure (IF) are at risk for both gastrointestinal (GI) and systemic complications, thus depending on a functioning network of multidisciplinary care. Data on the clinical impact of coronavirus disease 2019 (COVID-19) or the pandemic-related restrictions are limited. We aimed to analyse the clinical course of COVID-19 in children with IF, and to evaluate the perceived impact of the COVID-19 pandemic on IF patients and their caregivers by analysing quality of life (QoL), health-related QoL (HRQoL) and health care...
March 13, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38477348/longitudinal-screening-of-hla-risk-and-hla-nonrisk-children-for-celiac-disease-to-age-15-years-cipis-study
#35
JOURNAL ARTICLE
Michaela Boström, Charlotte Brundin, Sara Björck, Daniel Agardh
OBJECTIVES: Autoantibodies against tissue transglutaminase (tTG) are serological markers of celiac disease. The aim was to study the applicability of human leukocyte antigen (HLA)-genotyping and tTG autoantibodies in the screening of celiac disease in a longitudinal birth cohort followed to age 15 years. METHODS: Included were 13,860 HLA-DQ-genotyped children at birth and previously invited to a screening at age 3 and 9 years, respectively. HLA-DQB1*02 and/or DQB1*03:02 (HLA-risk) children were compared with non-HLA-DQB1*02 and non-DQB1*03:02 (HLA-nonrisk) children...
March 13, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38451061/catheter-salvage-from-central-line-related-bloodstream-infections-in-pediatric-intestinal-failure
#36
JOURNAL ARTICLE
Catherine Larson-Nath, Linder Wendt, Riad Rahhal
OBJECTIVES: Patients with intestinal failure require central venous access which puts them at risk for central line-associated bloodstream infections (CLABSI). Maintaining vascular patency is critical for this population to receive nutrition support. When CLABSIs occur line salvage can help maintain vascular access. The aim of this study is to assess factors associated with safe and successful central venous catheter salvage. METHODS: Retrospective cohort study of patients with intestinal failure at two tertiary care institutions between 2012 and 2020...
March 7, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38451058/a-multicenter-registry-study-on-percutaneous-electrical-nerve-field-stimulation-for-pediatric-disorders-of-gut-brain-interaction
#37
JOURNAL ARTICLE
Ashish Chogle, Khalil El-Chammas, Neha Santucci, Monica Grimm, Lev Dorfman, Kahleb Graham, Daniel R Kelly, Jason E Dranove, Rachel Rosen, Samuel Nurko, Joseph Croffie, Keshawadhana Balakrishnan, Eric H Chiou, Liyun Zhang, Pippa Simpson, Katja Karrento
OBJECTIVES: Percutaneous electrical nerve field stimulation (PENFS) has demonstrated promise in single-center trials for pediatric abdominal pain-related disorders of gut-brain interaction (DGBI). Our aim was to explore efficacy of PENFS as standard therapy for DGBI in a registry involving multiple pediatric gastroenterology referral centers. METHODS: This was a multicenter, prospective open-label registry of children (8-18 years) undergoing PENFS for DGBI at seven tertiary care gastroenterology clinics...
March 7, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38451054/isolated-small-bowel-ulcer-as-a-cause-of-severe-hemorrhage-diagnostic-challenge
#38
Margarida Vicente-Ferreira, Joana Lage, Joana Ribeiro, Céu Espinheira, Isabel Pinto Pais, Hélder Cardoso, Inês Teixeira, Eunice Trindade
No abstract text is available yet for this article.
March 7, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38451048/nut-consumption-during-pregnancy-is-associated-with-decreased-risk-of-peer-problems-in-5-year-old-japanese-children
#39
JOURNAL ARTICLE
Mai Quynh Nguyen, Yoshihiro Miyake, Keiko Tanaka, Shizuka Hasuo, Yoshitaka Nakamura, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa
OBJECTIVES: Nuts are nutrient-dense foods rich in unsaturated fatty acids, protein, dietary fiber, vitamins, and minerals. The present prebirth cohort study examined the association between maternal nut intake during pregnancy and the risk of childhood behavioral problems in 5-year-old Japanese children. METHODS: Study subjects were 1199 mother-child pairs. Dietary intake was assessed using a diet history questionnaire. Emotional problems, conduct problems, hyperactivity problems, peer problems, and low prosocial behavior were assessed using the parent-reported version of the Strengths and Difficulties Questionnaire...
March 7, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38451035/analysis-of-missed-clinic-visits-preferred-languages-and-telemedicine-in-a-pediatric-gastroenterology-practice
#40
JOURNAL ARTICLE
Bonnie Crume, Mohamed Suufi, Gloria Nabbosa, Lori Parker-Hartigan, Ashley McBride, Paul A Rufo, McGreggor Crowley
OBJECTIVES: Previous studies have demonstrated a relationship between socioeconomic disparities and missed clinic visits (MCV). However, the relationship between patient-preferred language and MCVs, particularly with respect to telemedicine, remains relatively underexplored. We sought to characterize the associations between MCV and patient-level predictors, including preferred language, in a large single-center pediatric gastroenterology, hepatology, and nutrition practice. METHODS: This retrospective longitudinal cohort study included all missed or completed outpatient visits in the Gastroenterology, Hepatology, and Nutrition Programs at Boston Children's Hospital from January 1, 2016 to May 20, 2022...
March 7, 2024: Journal of Pediatric Gastroenterology and Nutrition
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