Journal of Pediatric Gastroenterology and Nutrition

OBJECTIVES: To investigate long-term outcomes of antegrade continence enema (ACE) treatment in children with constipation or fecal incontinence. METHODS: Prospective cohort study including pediatric patients with organic or functional defecation disorders who started ACE treatment. Data were collected at baseline and at follow-up (FU) from 6 weeks until 60 months. We assessed parent and patient-reported gastrointestinal- health-related quality of life (HRQoL) using the Pediatric Quality of Life Inventory Gastrointestinal Symptoms Module (PedsQL™-GI), gastrointestinal symptoms, adverse events, and patient satisfaction...

OBJECTIVES: The indications, diagnostic yield, complications and cecal and ileal intubation rates (CIR and IIR) for colonoscopies in children aged < 6 years, denoted pre-schoolers, is unclear since there is limited information for this group. We aimed to describe the above parameters in our cohort of pre-schoolers undergoing a colonoscopy. METHODS: Retrospective review of all colonoscopies in a tertiary pediatric hospital between Dec 1, 2014 to Dec 31, 2020 was undertaken...

BACKGROUND: There is little data on gut microbiome and various factors that lead to dysbiosis in pediatric intestinal failure (PIF). This study aimed to characterize gut microbiome in PIF and determine factors that may affect microbial composition in these patients. METHODS: This is a single-center, prospective cohort study of children with PIF followed at our intestinal rehabilitation program. Stool samples were collected longitudinally at regular intervals over a one-year period...

OBJECTIVES: Patients with Trisomy 21 (T21) commonly have gastrointestinal symptoms and diseases that prompt evaluation with esophagogastroduodenoscopy (EGD). Our objective is to characterize duodenal histological abnormalities in these patients when undergoing EGD. A secondary aim is to explore associations of histologic findings with different therapies. METHODS: Patients 30 years old or younger with T21 who underwent EGD from 2000-2020 at six hospitals were included in this retrospective cohort study...

BACKGROUND: There are limited treatment options for children with steroid-refractory or dependent ulcerative colitis(UC). A few observational studies suggest efficacy of oral tacrolimus. We performed a systematic review and meta-analysis to assess the efficacy of tacrolimus in pediatric UC. METHODS: PubMed and Scopus were searched for publications related to the use of oral tacrolimus in pediatric UC. Data regarding the clinical response and colectomy-free survival were extracted from studies that met the selection criteria...

OBJECTIVES: Patient reported outcome measures (PROMs) facilitate evaluation of patients and allow to better assess treatment effects. Validated tools are lacking for paediatric gastroenterological patients. We thus aimed to adapt and validate for paediatric populations a self-administered Structured Assessment of Gastrointestinal Symptoms (SAGIS) tool that previously has been validated in adult cohorts. METHODS: Each item of the original SAGIS instrument was thoroughly reviewed for its relevance in the paediatric population...

Domperidone is a peripheral dopamine D2 receptor antagonist with prokinetic and antiemetic properties. Its prokinetic effects are mainly manifest in the upper gastrointestinal (GI) tract. Currently its use is restricted to relief of nausea and vomiting in children older than 12 years for a short period of time. However, among (paediatric) gastroenterologists, domperidone is also used outside its authorised indication ("off label") for treatment of symptoms associated with gastro-oesophageal reflux disease, dyspepsia and gastroparesis...

OBJECTIVES: Physical activity programs have been suggested as adjunctive therapy in adult IBD patients. We assessed the effects of a 12-week lifestyle intervention in children with IBD. METHODS: This study was a randomized semi-crossover controlled trial, investigating a 12-week lifestyle program (3 physical training sessions per week plus personalized healthy dietary advice) in children with IBD. Endpoints were physical fitness (maximal and submaximal exercise capacity, strength, and core stability), patient-reported outcomes (quality of life, fatigue, and fears for exercise), clinical disease activity (fecal calprotectin and disease activity scores), and nutritional status (energy balance and body composition)...

OBJECTIVE: Fetal growth restriction (FGR) indicates increased risks of lifestyle-related diseases in adulthood. Previous studies showed the association between human gut dysbiosis and various diseases. However, reports examining the relationship between FGR and gut microbiota are scarce. Herein, we hypothesized that FGR may cause gut dysbiosis and analyzed the gut microbiota in a FGR rat model by restricting maternal protein intake during pregnancy. METHODS: The FGR group was developed by feeding pregnant Sprague Dawley rats a diet containing 7% protein until birth...

No abstract text is available yet for this article.

The prevalence of pediatric serological negative celiac disease (SNCD) is poorly described, with few recognized clinical predictors beyond IgA deficiency or reduced gluten intake. The purpose of this retrospective review was to describe the prevalence of SNCD at the Stollery Children's Hospital and identify clinical features to help in recognition of these cases. Patients with a positive biopsy and negative serology (SNCD) were compared to those with positive biopsy and serology (SPCD). SNCD diagnosis required clinical correlation and either confirmatory genetics or follow up endoscopy on a gluten free diet...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

OBJECTIVES: In this study, we investigated the relationship between infantile colic, migraine, and biorhythm regulation, by evaluating biochemical and molecular parameters. STUDY DESIGN: Healthy infants with and without infantile colic were eligible for this prospective cohort study. A questionnaire was applied. Between the sixth and eighth postnatal weeks, day and night circadian histone gene H3f3bmRNA expression and spot urine excretion of serotonin, cortisol, and 6-sulphatoxymelatonin were analyzed...

We describe a cohort of 33 patients with eosinophilic esophagitis (EoE) and incidental duodenal bulb inflammation, termed bulbar duodenitis (BD). We conducted a single center retrospective cohort study and recorded demographics, clinical presentation, endoscopic and histological findings. BD was observed at the initial endoscopy in 12 cases (36%) and at a subsequent endoscopy in the remainder. Bulbar histology was usually a mix of chronic and eosinophilic inflammation. Patients were more likely to have active EoE (n=31, 96...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

OBJECTIVE: To compare feeding practices of low birthweight(LBW) infants, according to type of care received during and after hospital discharge: Kangaroo Care(KC) and Conventional Care(CC). METHODS: Prospective cohort study was conducted at a university hospital (Brazil) between 2019 and 2021. The sample consisted of 65 LBW infants (weight≤1,800grams)-46 in KC and 19 in CC. KC includes breastfeeding(BF) guidance and support to parents at hospital and after discharge...

INTRODUCTION/OBJECTIVES: As Intestinal failure (IF) management improves and long-term survival rate increases, its physiological complications have become more apparent. The development of chronic intestinal inflammation resembling Inflammatory Bowel Disease (IBD) in this population has been reported, but the literature describing it in detail is sparse. The present study was designed to characterize children with IF who developed chronic intestinal inflammation and identify the potential predisposing clinical factors...

OBJECTIVES: Our primary aim was to determine bowel and bladder function in children aged one month to seven years in the general Dutch population. Second, we aimed to identify demographic factors associated with the presence of bowel and bladder dysfunction, and their coexistence. METHODS: For this cross-sectional, population-based study, parents/caregivers of children aged from one month to seven years were asked to complete the Early Pediatric Groningen Defecation and Fecal Continence questionnaire...