Karlien Veldscholte, Jessie M Hulst, Renate D Eveleens, Rogier C J de Jonge, Barbara A E de Koning, Sjoerd A A van den Berg, Ronald van der Wal, George J G Ruijter, Dimitris Rizopoulos, Ilse Vanhorebeek, Jan Gunst, Michaël Casaer, Greet Van den Berghe, Koen F M Joosten, Sascha C A T Verbruggen
OBJECTIVES: Predicting the patients' tolerance to enteral nutrition (EN) would help clinicians optimize individual nutritional intake. This study investigated the course of several gastrointestinal (GI) biomarkers and their association with EN advancement (ENA) longitudinally during pediatric intensive care unit (PICU) admission. METHODS: This is a secondary analysis of the PEPaNIC RCT. EN was started early and increased gradually. The cholecystokinin (CCK), leptin, glucagon, intestinal fatty acid-binding protein 2 (I-FABP2), and citrulline plasma concentrations were measured upon PICU admission, day three and day five...
September 20, 2023: Journal of Pediatric Gastroenterology and Nutrition