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Journal of Pediatrics

Mihai Puia-Dumitrescu, P Brian Smith, Jian Zhao, Angela Soriano, Elizabeth H Payne, Barrie Harper, Ellen Bendel-Stenzel, Fernando Moya, Rakesh Chhabra, Lawrence Ku, Matthew Laughon, Kelly C Wade
OBJECTIVE: To characterize the dosing and safety of off-label caffeine citrate in a contemporary cohort of extremely premature infants. STUDY DESIGN: We used electronic health records (2010-2013) from 4 neonatal intensive care units to identify infants of ≤28 weeks of gestational age exposed to caffeine citrate. Safety outcomes included death, bronchopulmonary dysplasia, necrotizing enterocolitis, spontaneous intestinal perforation, intraventricular hemorrhage, patent ductus arteriosus ligation, seizures, and arrhythmias...
May 14, 2019: Journal of Pediatrics
Liane Eng, Molly O Regelmann
The lifetime risk for adrenal insufficiency in male children with adrenoleukodystrophy (ALD) is estimated at 80%-86%. Prior to newborn screening, male children with ALD were identified by family history or after symptom development. These young patients with ALD and adrenal insufficiency support newborn screening for ALD.
May 14, 2019: Journal of Pediatrics
Yue-Tong Qian, Jin-Yuan Ma, Jia-Wei Liu, Wei Liu, Dong-Lai Ma
No abstract text is available yet for this article.
May 14, 2019: Journal of Pediatrics
Amanda G Ruiz, Dexiang Gao, David G Ingram, Francis Hickey, Matthew A Haemer, Norman R Friedman
OBJECTIVES: To examine weight changes relative to surgical success in children with Down syndrome and obstructive sleep apnea (OSA). STUDY DESIGN: Retrospective chart review of children with Down syndrome undergoing tonsillectomy from 2005 to 2016 for OSA at a tertiary care children's hospital. Only patients with pre-and postoperative polysomnogram within 6 months of tonsillectomy were included. Demographics, weight, height, and polysomnogram data were collected...
May 10, 2019: Journal of Pediatrics
Rajan R Murgai, Liam R Harris, Paul D Choi, Rachel Y Goldstein
OBJECTIVE: To examine the relationship between socioeconomic factors and outcomes of developmental dysplasia of the hip (DDH). STUDY DESIGN: A retrospective review of patients with DDH at a tertiary pediatric hospital from 2003 to 2012 with 2 years minimum follow-up was conducted. The relationship between socioeconomic factors with late presentation, treatment, and outcomes was examined. Socioeconomic factors included insurance status, language, and ethnicity. RESULTS: In total, 188 patients met criteria...
May 9, 2019: Journal of Pediatrics
Roberto Raschetti, Nadya Yousef, Giulia Vigo, Gianluigi Marseglia, Roberta Centorrino, Rafik Ben-Ammar, Shivani Shankar-Aguilera, Daniele De Luca
OBJECTIVE: To improve time of surfactant administration with a surfactant replacement protocol based on semiquantitative lung ultrasound score (LUS) thresholds. STUDY DESIGN: Quality improvement (QI), prospective, before-after, pilot study. In a 6-month period surfactant replacement was based only on inspired oxygen fraction (FiO2 ) thresholds. In the second 6-month period, surfactant was given when either the FiO2 or LUS exceeded the limits. The main QI measures were the proportion of neonates receiving surfactant within the first 3 hours of life and maximal FiO2 reached before surfactant replacement...
May 9, 2019: Journal of Pediatrics
Jeremy D Woods, Kurlen S E Payton, Pedro A Sanchez-Lara, Margaret Au, Charles F Simmons, John M Graham
Meconium ileus is caused by cystic fibrosis; however, mutations in the GUCY2C gene also cause this disease. We report non-cystic fibrosis meconium ileus in an infant of non-Middle Eastern origin with compound heterozygous mutations in GUCY2C.
May 9, 2019: Journal of Pediatrics
Emily A Eismann, Alonzo T Folger, Nicole B Stephenson, Maggie E Brownrigg, Robert A Shapiro, Maurizio Macaluso, R J Gillespie
OBJECTIVE: To determine whether maternal and paternal exposure to adverse childhood experiences (ACEs) has an association with offspring healthcare use by 2 years of age. STUDY DESIGN: A retrospective cohort study was performed on 454 patients at a large suburban pediatric primary care practice whose mother (n = 374) or father (n = 156) or both (n = 123) completed an ACE survey between October 2012 and June 2014. The association between self-reported parental ACEs and healthcare use by 2 years of age, including number of missed well-child visits, sick visits, and delayed or missed immunizations, was modeled using multivariable negative binomial regression...
May 9, 2019: Journal of Pediatrics
Steven A Abrams, Stephen R Daniels
No abstract text is available yet for this article.
May 9, 2019: Journal of Pediatrics
Lindsay A Taliaferro, Brittany M Harder, Nik M Lampe, Shannon K Carter, G Nic Rider, Marla E Eisenberg
OBJECTIVE: To compare social connectedness factors that facilitate use of primary, dental, and mental healthcare services among transgender and gender nonconforming (TGNC) and cisgender adolescents. METHODS: Data from the cross-sectional 2016 Minnesota Student Survey were used to examine protective social connectedness factors associated with use of different healthcare services among matched samples of 1916 TGNC and 1916 cisgender youth. Stratified, logistic regression analyses were used to examine background characteristics and social connectedness factors (parent connectedness, connections to other nonparental adults, teacher-student relationships, and friend connections) associated with use of each healthcare service within the last year...
May 9, 2019: Journal of Pediatrics
Genevieve F Dunton, David Berrigan, Deborah Rohm Young, Karin Allor Pfeiffer, Sarah M Lee, Sandy J Slater, Russell R Pate
No abstract text is available yet for this article.
May 8, 2019: Journal of Pediatrics
Alfonso Galderisi, Fiorella Calabrese, Francesco Fortarezza, Steve Abman, Eugenio Baraldi
Long-term survivors of bronchopulmonary dysplasia develop chronic obstructive lung disease. Herein we report in vivo histopathology from bronchial biopsies of 3 adolescent survivors of severe bronchopulmonary dysplasia. Thickened basement membranes with lymphocytic infiltrates and signs of immature neoangiogenesis in the absence of T-helper lymphocytes or eosinophils suggest the presence of an ongoing active airway process.
May 7, 2019: Journal of Pediatrics
Karl C K Kuban, Hernan Jara, T Michael O'Shea, Timothy Heeren, Robert M Joseph, Raina N Fichorova, Khalid Alshamrani, Adam Aakil, Forrest Beaulieu, Mitchell Horn, Laurie M Douglass, Jean A Frazier, Deborah Hirtz, Julie Vanier Rollins, David Cochran, Nigel Paneth
OBJECTIVES: To examine elevated neonatal inflammatory and neurotrophic proteins from children born extremely preterm in relation to later childhood brain Magnetic Resonance Imaging volumes and cognition. STUDY DESIGN: We measured circulating inflammation-related proteins and neurotrophic proteins on postnatal days 1, 7, and 14 in 166 children at 10 years of age (73 males; 93 females). Top quartile levels on ≥2 days for ≥3 inflammation-related proteins and for ≥4 neurotrophic proteins defined exposure...
May 7, 2019: Journal of Pediatrics
Sandra Schulte, Bettina Gohlke, Felix Schreiner, Mathias Gruenewald, Rolf Fimmers, Birgit Stoffel-Wagner, Peter Bartmann, Joachim Woelfle
OBJECTIVE: To analyze the long-term impact of birth weight (BW) on thyroid function in genetically identical twins with intra-twin BW differences from birth to adolescence. STUDY DESIGN: In total, 52 monozygotic twin pairs underwent at least one analysis of thyroid function at mean ages of 10.1 years (27 pairs), 15.1 years (35 pairs), and 17.4 years (36 pairs); 18 pairs donated blood at all time points. BW difference of <1 SDS was defined as concordant, BW difference ≥1 SDS as discordant...
May 7, 2019: Journal of Pediatrics
Berengere François, Laurent Michaud, Rony Sfeir, Arnaud Bonnard, Veronique Rousseau, Sebastien Blanc, Thomas Gelas, Julia Boubnova, Catherine Jacquier, Sabine Irtan, Anne Breton, Virginie Fouquet, Audrey Guinot, Thierry Lamireau, Edouard Habounimana, Anne Schneider, Frederic Elbaz, Aline Ranke, Marie-Laurence Poli-Merol, Nicolas Kalfa, Claire Dupont-Lucas, Thierry Petit, Jean-Luc Michel, Philippe Buisson, Josephine Lirussi-Borgnon, Emmanuel Sapin, Hubert Lardy, Guillaume Levard, Benoit Parmentier, Clara Cremillieux, Manuel Lopez, Guillaume Podevin, Françoise Schmitt, Corinne Borderon, Olivier Jaby, Cecile Pelatan, Philine De Vries, Myriam Pouzac-Arnould, Celine Grosos, Jean Breaud, Christophe Laplace, Cecilia Tolg, Anicet Sika, Frederic Auber, Julien Labreuche, Alain Duhamel, Frederic Gottrand
OBJECTIVE: To identify predictors of and factors associated with the performance of antireflux surgery during the first year of life in children born with esophageal atresia. STUDY DESIGN: All patients were included in a French registry for esophageal atresia. All 38 multidisciplinary French centers completed questionnaires about perinatal characteristics and one-year outcome for children born with esophageal atresia. RESULTS: Of 835 infants with esophageal atresia born in France from 2010 to 2014, 682 patients, excluding those with long-gap esophageal atresia, were included...
May 6, 2019: Journal of Pediatrics
Allison E Curry, Kristy B Arbogast, Kristina B Metzger, Ronni S Kessler, Matthew J Breiding, Juliet Haarbauer-Krupa, Lara DePadilla, Arlene Greenspan, Christina L Master
OBJECTIVE: To quantify the risk of repeat concussions for children and identify demographic and clinical aspects of the index concussion associated with repeat injury. STUDY DESIGN: For this retrospective cohort study, we queried the Children's Hospital of Philadelphia healthcare network's unified electronic health record to identify all 5- to 15-year-old patients who had their first clinical visit for an index concussion at a Children's Hospital of Philadelphia location from July 2012 through June 2013...
May 4, 2019: Journal of Pediatrics
Allison L B Shapiro, Greta Wilkening, Jenny Aalborg, Brandy M Ringham, Deborah H Glueck, Jason R Tregellas, Dana Dabelea
OBJECTIVE: To evaluate the hypothesis that metabolic measures (fasting glucose, insulin, and Homeostatic Model of Assessment for Insulin Resistance [HOMA-IR] levels) are inversely associated with performance on cognitive tasks using data from young (4- to 6-year-old), typically developing, healthy children. STUDY DESIGN: Data were obtained from children participating in the Healthy Start study, a pre-birth cohort in Colorado. HOMA-IR, glucose, and insulin values were centered and scaled using the study sample means and SD...
May 3, 2019: Journal of Pediatrics
Kai-Yu Ho, Jing Nong Liang
No abstract text is available yet for this article.
May 3, 2019: Journal of Pediatrics
Elizabeth Quincer, Preeti Jaggi
No abstract text is available yet for this article.
May 3, 2019: Journal of Pediatrics
Leslie A Parker, Nicole Cacho, Clara Engelmann, Jaime Benedict, Susan Wymer, Weaver Michael, Josef Neu
OBJECTIVE: To compare mothers' own milk (MOM) consumption by infants born extremely preterm before and after implementation of a donor human milk (DHM) program and determine healthcare provider's knowledge and practices regarding DHM. STUDY DESIGN: One hundred fifty-seven infants born at <30 weeks of gestation were enrolled during 3 time-periods. Group 1: before DHM program implementation, Group 2: the year following implementation, and Group 3: the second year after implementation...
May 3, 2019: Journal of Pediatrics
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