Journal of Pediatrics

OBJECTIVE: To assess the diagnostic accuracy and to develop prediction tools for iron deficiency in 2-year-old children. STUDY DESIGN: In a national cross-sectional study conducted in primary care pediatricians' practices throughout France, 2-year-old children were consecutively included (2016-2017). Multivariable logistic regression modeling and bootstrapping were used to develop several clinical models to predict ID (serum ferritin <12 μg/L). These models used the best criteria and combinations among the American Academy of Pediatrics' (AAP) criteria adapted to the European context (n=10), then all potential predictors (n=19)...

OBJECTIVE: To examine self-reported and parent-reported health-related quality of life (HRQL) in adults born extremely preterm compared with term-born controls and to evaluate trajectories of health status from adolescence to early adulthood. STUDY DESIGN: The EPICure study comprises all births <26 weeks of gestation in the United Kingdom (UK) and Ireland in 1995 and term-born controls recruited at age 6. 129 participants born extremely preterm and 65 controls were followed up at the 19-year assessment...

OBJECTIVES: To prospectively quantify bleeding severity and elaborate hemorrhagic symptoms in children with 22q11.2 deletion syndrome (22q11DS) using two validated bleeding-assessment-tools (BATs), namely the pediatric bleeding questionnaire (PBQ) and the International Society on Thrombosis and Hemostasis BAT (ISTH-BAT). We additionally sought to compare subjects' bleeding scores to unaffected first-degree family members. STUDY DESIGN: Children with 22q11DS and unaffected first-degree family members were recruited for the study...

OBJECTIVE: To estimate the incidence of blood product transfusion, including red blood cells, platelets, and plasma, and characterize pre-transfusion hematologic values for infants during their initial hospitalization after birth. STUDY DESIGN: Retrospective cohort study using data from 7 geographically diverse US academic and community hospitals that participated in the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) from 2013-2016...

OBJECTIVE: To describe the clinical characteristics, treatment, and outcomes of a multinational cohort of patients with macrophage activation syndrome (MAS) and thrombotic microangiopathy (TMA). STUDY DESIGN: International pediatric rheumatologists were asked to collect retrospectively the data of patients with the co-occurrence of MAS and TMA. Clinical and laboratory features of patients with systemic juvenile idiopathic arthritis (sJIA)-associated MAS and TMA were compared with those of an historical cohort of patients with sJIA and MAS...

OBJECTIVE: To evaluate sex differences in microRNA (miRNA) expression, anthropometric measures and cardiometabolic risk factors in Hispanic adolescents with obesity. STUDY DESIGN: Cross-sectional study of 68 (60% male) Hispanic adolescents with obesity, aged 13-17 years, recruited from a pediatric weight management clinic. We used small RNA sequencing to identify differentially expressed circulating miRNAs. We used Ingenuity Pathway Analysis and David bioinformatic resource tools to identify target genes for these miRNAs and enriched pathways...

No abstract text is available yet for this article.

OBJECTIVES: To evaluate the utility of a digital psychological self-assessment tool, MyHEARTSMAP, in youth presenting to the pediatric emergency department (ED) with a mental health concern. STUDY DESIGN: We conducted a prospective cohort study in two tertiary care pediatric EDs from December 2017-October 2019. Youth 10-17 years old triaged for a mental health concern were screened and enrolled to complete MyHEARTSMAP on a mobile device. A clinician blinded to the MyHEARTSMAP assessment conducted their own assessment which was used as the reference standard...

OBJECTIVE: To report vigilance attention outcomes from a cluster randomized controlled trial of early childhood development caregiver training for perinatally HIV-exposed/uninfected preschool-age children in rural Uganda. The Early Childhood Vigilance Test (ECVT) provides a webcam recording of proportion of time a child views an animation periodically moving across a computer screen. STUDY DESIGN: Sixty mothers/caregivers received biweekly year-long training sessions of the Mediational Intervention for Sensitizing Caregivers (MISC) and 59 mothers received biweekly training about nutrition, hygiene, and healthcare...

OBJECTIVE: The primary objectives of the study were to describe the association between cardiac manifestations and in-hospital mortality among children with Hemolytic Uremic Syndrome (HUS). STUDY DESIGN: Using the Pediatric Health Information System database, this retrospective, multi-center, cohort study identified the first HUS-related inpatient visit among children <=18 years (years 2004 to 2018). Frequency of selected cardiac manifestations and mortality rates were calculated...

No abstract text is available yet for this article.

OBJECTIVE: To assess prevalence of and factors associated with left ventricular diastolic dysfunction (LVDD) in youth with obesity and elevated blood pressure (BP). STUDY DESIGN: Cross-sectional analyses of baseline and follow up visits of 83 youth, 5-21 years, evaluated for overweight/obesity and elevated BP in a multidisciplinary clinic. LVDD was defined according to established adult criteria (LVDDadult ; E/A<1, E/e'>14, or e'/a'<0.8) and pediatric criteria (LVDDpeds ; E/A<10th percentile, E/e'>99th percentile, or e'/a'< 1st percentile) based on data from 103 age-sex matched healthy controls...

No abstract text is available yet for this article.

OBJECTIVE: To assess justice system involvement among adolescents in the pediatric emergency department (ED) and identify associations with risk and protective factors. STUDY DESIGN: We conducted a cross-sectional computerized survey of adolescents to assess for personal , JSI, and non-household JSI (ie, important people outside of household). We assessed sexual behaviors, violent behaviors, substance use, school suspension/expulsion, parental supportiveness, and participant mood (score <70 indicates psychological distress)...

OBJECTIVE: To measure adherence rates to swallowed topical steroids in children with eosinophilic esophagitis (EoE), describe factors related to adherence, and determine the association between adherence, symptoms, perceived disease severity, and quality of life in children with EoE. STUDY DESIGN: Subjects in this cross-sectional study of 117 children between 5-18 years old with EoE completed the Pediatric Eosinophilic Esophagitis Symptoms Score V2.0 (PEESS), Pediatric Quality of Life Inventory Eosinophilic Esophagitis Module (PedsQL EoE), a Medication-Taking Checklist (MTC), and a demographics questionnaire...

OBJECTIVES: To examine whether the order of presenting survival versus disability information, with or without the description of infant NICU experiences would influence treatment choice during hypothetical periviable birth counseling. STUDY DESIGN: An internet sample of childbearing-aged women (N = 839) viewed a pictograph displaying the chances of survival and a pictograph on the chances of disability for a baby resuscitated during the periviable period. The sample was randomized to the order of pictographs and level of description of infant NICU experiences...

OBJECTIVE: To estimate the impact of the PediBIRN (Pediatric Brain Injury Research Network) 4-variable clinical decision rule (CDR) on abuse evaluations and missed abusive head trauma in pediatric intensive care settings. STUDY DESIGN: Cluster randomized trial. Participants were 8 pediatric intensive care units (PICUs) in US academic medical centers; PICU and child abuse physicians; and consecutive acutely head-injured patients <3 years (n=183 and n=237, intervention vs...

No abstract text is available yet for this article.

OBJECTIVES: To describe care coordination experience for families of children with IBD and compare use of health services between families who identified a primary care physician (PCP) versus gastroenterologist as a child's main provider. STUDY DESIGN: Cross-sectional survey of care coordination experience and health services use for children 6-19 years old receiving care in the IBD program at a children's hospital during 2018. English-speaking parents completed the Family Experiences with Coordination of Care (FECC) Survey about their child's "main provider" and reported past-year health services...

OBJECTIVE: To determine the effects of different doses of prophylactic dextrose gel on glycemic stability assessed using continuous interstitial glucose monitoring (CGM) in the first 48 hours when given to babies at risk of neonatal hypoglycemia. STUDY DESIGN: CGM was undertaken for the first 48 hours in 133 infants at risk of hypoglycemia who participated in the pre-hPOD randomized dosage trial of dextrose gel prophylaxis. RESULTS: Low glucose concentrations were detected in 41% of infants by blood glucose monitoring and 68% by CGM...