Journal of Pediatrics

OBJECTIVE: To investigate the quality of life (QoL) impact on primary caregivers of children with esophageal atresia. STUDY DESIGN: We employed a prospective cohort study design, inviting primary caregivers of children with EA to complete the following questionnaires: (1) Parent Experience of Child Illness (PECI); (2) Patient-Reported Outcomes Measurement Information System (PROMIS) Anxiety; (3) PROMIS Depression; (4) 12-Item Short Form Survey (SF-12); and; (5) Pediatric Quality of Life Inventory (PedsQL); The PECI, PROMIS Anxiety and Depression, and SF-12 assessed caregiver QoL, and PedsQL assessed patient QoL...

OBJECTIVE: To examine the associations between family-reported social needs in primary care settings and pediatric health care use. STUDY DESIGN: Data were used from a sample of 56,253 children (ages 0-21) who received primary care at a large hospital-based pediatric institution between June 2018 and October 2019 to estimate a propensity score for the probability of being seen in a primary care clinic. Inverse probability weighted regression specifications were used to understand the associations between reported social needs and health care use...

OBJECTIVES: To evaluate the role of childcare facilities in the transmission of SARS-CoV-2, we conducted a longitudinal study to gain further knowledge on SARS-CoV-2 prevalence, transmission and spread among preschool children, their parents and caretakers. STUDY DESIGN: Children between 1 and 6 years of age, their parents and caregivers in 14 childcare facilities in Dresden, Saxony/Germany were invited to participate in the KiTaCoviDD19-study between July 2020 and January 2021...

OBJECTIVE: To assess the epidemiologic association between Kawasaki disease and common pediatric infectious diseases (PIDs) identified during the coronavirus disease 2019 (COVID-19) pandemic period to confirm whether the infection-triggered theory is a plausible hypothesis for pathogenesis of Kawasaki disease. STUDY DESIGN: A retrospective epidemiologic study was conducted using datasets obtained from web-based KD surveillance and surveillance of infectious diseases in Japan...

OBJECTIVES: To test whether an increased iron dose is associated with improved neurodevelopment as assessed by the Bayley Scales of Infant Development (BSID-III) among infants enrolled in the Preterm Erythropoietin (Epo) Neuroprotection Trial (PENUT). STUDY DESIGN: This is a post hoc analysis of a randomized trial which enrolled infants born at 24 to 28 completed weeks of gestation. All PENUT infants who were assessed with BSID-III at 2 years were included in this study...

OBJECTIVE: To describe the characteristics and clinical course of children and young people with inflammatory bowel disease and sclerosing cholangitis (IBD-SC). STUDY DESIGN: Retrospective analysis of clinical characteristics, management, and outcome of two separate cohorts of children and young people with IBD-SC managed in a tertiary pediatric gastroenterology center and in a tertiary pediatric hepatology center in the UK. RESULTS: 82 pediatric patients (31% female) with IBD-SC and a mean age at diagnosis of 11...

No abstract text is available yet for this article.

OBJECTIVES: To confirm that WHO weight-for-length Z-scores (zWFL) and WHO body mass index Z-scores (zBMI) in infancy are associated with adiposity and cardiometabolic measures at 8-10 years old and to compare the predictive ability of the two methods. STUDY DESIGN: WFL and BMI Z-scores at 6, 12, and 18 months of age were computed using data extracted from health booklets, among participants in the Quebec Adipose and Lifestyle InvesTigation in Youth prospective cohort (n = 464)...

No abstract text is available yet for this article.

OBJECTIVES: To evaluate the sex-specific effects of stimulants in children with Attention-Deficit/Hyperactivity Disorder (ADHD) on body mass index (BMI)-Z and Height-Z trajectories. STUDY DESIGN: A retrospective cohort study utilizing the database of Israel Clalit Health Services. Participants included 5-18-year-old insureds with documentation of at least two consecutive prescriptions of stimulant drugs for ADHD. Participants were further compared with sex and age matched non-ADHD insureds...

OBJECTIVES: To assess whether weaning to an extensively hydrolyzed formula (EHF) decreases gut permeability and/or markers of intestinal inflammation in infants with HLA-conferred diabetes susceptibility, when compared with conventional formula. STUDY DESIGN: By analyzing 1468 expecting biological parent pairs for HLA-conferred susceptibility for type 1 diabetes, 465 couples (32%) potentially eligible for the study were identified. After further parental consent, 332 babies to be born were randomized at 35th gestational week...

OBJECTIVES: To define the incidence and characteristics of influenza-associated neurologic complications in a cohort of children hospitalized at a tertiary care pediatric hospital with laboratory-confirmed influenza, and to identify associated clinical, epidemiologic, and virologic factors. STUDY DESIGN: Historical cohort study of children 0.5-18.0 years-old hospitalized between 2010-2017 with laboratory-confirmed influenza. Children with immune compromise or a positive test due to recent receipt of live virus vaccine or recently resolved illness were excluded...

No abstract text is available yet for this article.

OBJECTIVES: To assess the rate of spontaneous closure and the incidence of adverse events in infants discharged home with a patent ductus arteriosus. STUDY DESIGN: In a prospective multicenter study, we enrolled 201 premature infants (gestational age 23-32 weeks at birth) discharged home with a persistently patent ductus arteriosus (PDA) and followed their PDA status at 6-month intervals through 18 months of age. The primary study outcome was the rate and timing of spontaneous ductal closure...

OBJECTIVE: To determine the trends in testing and incidence of vitamin D deficiency/insufficiency in Olmsted County, Minnesota over a 16 year period. STUDY DESIGN: The Rochester Epidemiology Project (REP) was used to identify Olmsted County, Minnesota residents <19 years of age who had 25-hydroxyvitamin D (25(OH)D) levels measured between January 2, 2002 and December 31, 2017. Using each patient's first 25(OH)D measurement during this period, patients were categorized into 3 groups: <20ng/ml, 20-50ng/ml, or >50 ng/mL...

OBJECTIVES: To evaluate Quality of Life (QoL) in a large cohort of pediatric patients with Inflammatory Bowel Disease (IBD) and to identify the clinical factors that influence QoL. STUDY DESIGN: This cross-sectional study analyzes a quality improvement initiative in 351 pediatric patients with IBD in British Columbia, Canada using the self-reported PedsQL 4.0 generic scale. The questionnaire was completed at outpatient clinic and biologic infusion appointments. Statistical analysis included the t-test, ANOVA and multilinear regressions to evaluate the relationships between clinical factors and QoL...

No abstract text is available yet for this article.

In a national survey of 2,074 US parents of children <12 years old conducted in March 2021, 49.4% reported plans to vaccinate their child for COVID-19 when available. Lower income and less education were associated with greater parental vaccine hesitancy/resistance; safety and lack of need were primary reasons for vaccine hesitancy/resistance.

No abstract text is available yet for this article.

OBJECTIVES: To evaluate various clinical aspects, specifically regarding immune status, in a large cohort of patients with DGS. STUDY DESIGN: Data were collected of 98 patients with DGS treated at a tertiary medical center. This included general information, laboratory results, and clinical features. RESULTS: The median age at diagnosis was 2.0 (range: 0.0-36.5) years. The most common symptoms that led to diagnosis were congenital heart defect, speech delay, palate anomalies, and developmental delay...