Journal of Pediatrics

Giulia M Benedetti, Rebecca J Vartanian, Harlan McCaffery, Renée A Shellhaas
OBJECTIVE: To evaluate whether features of the early electroencephalographic (EEG) background could guide the optimal duration of continuous video EEG monitoring for seizure detection in newborn infants treated with therapeutic hypothermia for hypoxic ischemic encephalopathy (HIE). STUDY DESIGN: Retrospective cohort study of 114 consecutive infants treated with therapeutic hypothermia for moderate to severe HIE at a level IV neonatal intensive care unit (NICU) between 2012 and 2018...
March 25, 2020: Journal of Pediatrics
Francesco Cavallin, Maria Sofia Cori, Senait Negash, Gaetano Azzimonti, Giovanni Vento, Giovanni Putoto, Daniele Trevisanuto
OBJECTIVE: To compare 2 different methods (auscultation with a stethoscope and umbilical cord palpation) of heart rate (HR) estimation in newborns at risk for resuscitation in a low-resource setting. STUDY DESIGN: Sixty newborns at risk for resuscitation born at the St. Luke Catholic Hospital in Wolisso (Ethiopia) were randomized to HR assessment by auscultation using a stethoscope or umbilical cord palpation. HR was assessed at 60, 90, 120 seconds, and 5 minutes of life...
March 25, 2020: Journal of Pediatrics
Russell E Ware, Anu Marahatta, Julie L Ware, Kathryn McElhinney, Min Dong, Alexander A Vinks
Lactation is contraindicated for women with sickle cell anemia receiving hydroxyurea therapy, despite sparse pharmacokinetics data. In 16 women who were lactating volunteers, we documented hydroxyurea transferred into breastmilk with a relative infant dosage of 3.4%, which is below the recommended 5%-10% safety threshold. Breastfeeding should be permitted for women taking daily oral hydroxyurea.
March 11, 2020: Journal of Pediatrics
Margaret A Heller, Meredith N Lind, Emily F Boss, Jennifer N Cooper
OBJECTIVE: To evaluate whether differences in pediatric tonsillectomy use by race/ethnicity and type of insurance were impacted by the American Academy of Otolaryngology-Head and Neck Surgery's 2011 tonsillectomy clinical practice guidelines. STUDY DESIGN: We included children aged <15 years from Florida or South Carolina who underwent tonsillectomy in 2004-2017. Annual tonsillectomy rates within groups defined by race/ethnicity and type of health insurance were calculated using US Census data, and interrupted time series analyses were used to compare the guidelines' impact on utilization across groups...
March 11, 2020: Journal of Pediatrics
Morgan Amigo, Nima Milani-Nejad, Joy Mosser-Goldfarb
No abstract text is available yet for this article.
March 11, 2020: Journal of Pediatrics
Margot Miranda-Katz, Deepika Parmar, Rebecca Dang, Amy Alabaster, Tara L Greenhow
OBJECTIVE: To assess which risk factors are associated with community-associated Clostridioides difficile infection (CDI) in children. STUDY DESIGN: This case control study was a retrospective review of all children 1-17 years of age with stool specimens sent for C difficile testing from January 1, 2012, to December 31, 2016. Cases and controls were children who had C difficile testing performed in the community or first 48 hours of hospital admission and >12 weeks after hospital discharge, with no prior positive C difficile testing in last 8 weeks, without other identified causes of diarrhea, and with clinical symptoms...
March 11, 2020: Journal of Pediatrics
Anna B Fishbein, Noor Hamideh, Jennifer Lor, Sharon Zhao, Lacey Kruse, Maryann Mason, Adolfo Ariza, Liliana Bolanos, Jonathan Necheles, Bennett Kaye
OBJECTIVES: To characterize primary care providers' (PCPs) practice patterns for atopic dermatitis (AD) in children <2 years old and determine the need for AD guidelines for PCPs focused on this age group. STUDY DESIGN: This is a mixed-methods study consisting of a survey and a retrospective medical record review of PCP practices in the Chicago metropolitan area. The survey was analyzed using both quantitative and qualitative methods. RESULTS: In the survey (n = 52 respondents), PCPs reported management of AD is different in children <2 years compared with older children (88%)...
March 11, 2020: Journal of Pediatrics
Michael A Cardis, Robert A Silverman
No abstract text is available yet for this article.
March 11, 2020: Journal of Pediatrics
Sabrina Belkaibech, Brian J Potter, Harb Kang, Ga Eun Lee, Marianne Bilodeau-Bertrand, Nathalie Auger
We assessed the association between maternal autoimmune disorders and offspring risk of Kawasaki disease in a longitudinal cohort of 792 108 newborns. We found that maternal autoimmune disorders, especially autoimmune thyroiditis, may be risk factors for Kawasaki disease in children, particularly young children.
March 11, 2020: Journal of Pediatrics
Massimo Pettoello-Mantovani, Julije Mestrovic, Mehmet Vural, Leyla Namazova-Baranova
No abstract text is available yet for this article.
March 6, 2020: Journal of Pediatrics
Michael D Johnson, Joseph J Zorc, Douglas S Nelson, Theron Charles Casper, Lawrence J Cook, Yaron Finkelstein, Lynn Babcock, Lalit Bajaj, James M Chamberlain, Robert W Grundmeier, Michael Webb, Elizabeth R Alpern
OBJECTIVE: To examine the use, efficacy, and safety of intravenous magnesium sulfate (IVMg) in children with asthma whose emergency department (ED) management is recorded in the Pediatric Emergency Care Applied Research Network (PECARN) Registry. STUDY DESIGN: This multicenter retrospective cohort study analyzed clinical data from 7 EDs from 2012 to 2017. We described use of IVMg in children aged 2-17 years treated for acute asthma and its effect on blood pressure...
March 5, 2020: Journal of Pediatrics
Nehal A Parikh, Lili He, Venkata Sita Priyanka Illapani, Mekibib Altaye, Alonzo T Folger, Keith O Yeates
OBJECTIVE: To externally validate the independent value of objectively diagnosed diffuse white matter abnormality (DWMA; also known as diffuse excessive high signal intensity) volume to predict neurodevelopmental outcomes in very preterm infants (≤31 weeks of gestational age). STUDY DESIGN: A prospective, multicenter, regional population-based cohort study in 98 very preterm infants without severe brain injury on magnetic resonance imaging (MRI). DWMA volume was diagnosed objectively on structural MRI at term-equivalent age using our published algorithm...
March 5, 2020: Journal of Pediatrics
Thomas A Miller, Amy J Lisanti, Madolin K Witte, Justin J Elhoff, William T Mahle, Karen C Uzark, Nneka Alexander, Samantha C Butler
OBJECTIVE: Assess differences in approaches to and provision of developmental care for infants undergoing surgery for congenital heart disease. STUDY DESIGN: A collaborative learning approach was used to stratify, assess, and compare individualized developmental care practices among multidisciplinary teams at 6 pediatric heart centers. Round robin site visits were completed with structured site visit goals and postvisit reporting. Practices of the hosting site were assessed by the visiting team and reviewed along with center self-assessments across specific domains including pain management, environment, cue-based care, and family based care coordination...
March 5, 2020: Journal of Pediatrics
Benard P Dreyer
No abstract text is available yet for this article.
March 5, 2020: Journal of Pediatrics
Michael W Kirkwood, Maria M Crossland, David R Howell, Julie C Wilson, Robin L Peterson
OBJECTIVE: To prospectively evaluate symptom outcomes after youth soccer-related concussion. STUDY DESIGN: Using a prospective cohort design, we enrolled male and female competitive soccer players age 8-17 years into 3 groups: concussed (n = 23), matched control (n = 23), and orthopedic injury (n = 24). Postconcussive symptoms were monitored serially via both athlete and parent report at days 1-2, 4, 7, 10, 30, and 90. RESULTS: Repeated-measures analyses revealed a significant time by group interaction (F [12, 402] = 19...
March 5, 2020: Journal of Pediatrics
Jessica D Wharton, Megan M Barry, Chelsea A Lee, Kayla Massey, Travis R Ladner, Lori C Jordan
OBJECTIVE: To examine the implementation and utilization of a pediatric acute stroke protocol over a 7-year period, hypothesizing improvements in protocol implementation and increased protocol use over time. STUDY DESIGN: Clinical and demographic data for this retrospective observational study from 2011 through 2018 were obtained from a quality improvement database and medical records of children for whom the acute stroke protocol was activated. The initial 43 months of the protocol (period 1) were compared with the subsequent 43 months (period 2)...
March 5, 2020: Journal of Pediatrics
Richard P Wennberg, Stephen Oguche, Zainab Imam, Zubaida L Farouk, Isa Abdulkadir, Paul D Sampson, Tina M Slusher, Fidelia Bode-Thomas, Bose O Toma, Christopher S Yilgwan, David Shwe, Akinyemi O Ofakunrin, Udochukwu M Diala, Chris Isichei, Victor Pam, Zuwaira Hassan, Shehu U Abdullahi, Fatima Usman, Binta W Jibir, Idris Y Mohammed, Hadiza A Usman, Muhammed Abdusalam, Aisha Kuliya-Gwarzo, Fatima I Tsiga-Ahmad, Laila Umar, William N Ogala, Fatimatu Abdullahi, Laila Hassan, Saratu Purdue, Troy Lund, Carlos D Coda-Zabetta
OBJECTIVE: To evaluate whether teaching mothers about neonatal jaundice will decrease the incidence of acute bilirubin encephalopathy among infants admitted for jaundice. STUDY DESIGN: This was a multicenter, before-after and cross-sectional study. Baseline incidences of encephalopathy were obtained at 4 collaborating medical centers between January 2014 and May 2015 (Phase 1). Structured jaundice instruction was then offered (May to November 2015; Phase 2) in antenatal clinics and postpartum...
March 4, 2020: Journal of Pediatrics
Sriram Ramgopal, Paria M Wilson
We conducted a secondary analysis of a prospective study of infants ≤60 days of age who were febrile to assess the diagnostic accuracy of automated vs manual immature neutrophils for invasive bacterial infections. Although manual counts were superior compared with automated counts, bands had suboptimal accuracy overall and had significant variability in test characteristics based on methodology.
March 4, 2020: Journal of Pediatrics
Bridget Hron, Rachel Rosen
No abstract text is available yet for this article.
March 4, 2020: Journal of Pediatrics
Aline Cano, Noemie Resseguier, Abdoulaye Ouattara, Pascale De Lonlay, Jean-Baptiste Arnoux, Anais Brassier, Manuel Schiff, Samia Pichard, Alexandre Fabre, Celia Hoebeke, Nathalie Guffon, Alain Fouilhoux, Pierre Broué, Guy Touati, Dries Dobbelaere, Karine Mention, Francois Labarthe, Marine Tardieu, Loïc De Parscau, Francois Feillet, Chrystèle Bonnemains, Alice Kuster, Philippe Labrune, Magalie Barth, Lena Damaj, Delphine Lamireau, Julie Berbis, Brigitte Chabrol, Pascal Auquier
OBJECTIVE: To describe the health status of young patients affected by inborn errors of metabolism that require adherence to a restricted diet (IEMRDs) and to describe and compare their self- and proxy (parent)-reported quality of life (QoL) with reference values. STUDY DESIGN: A cross-sectional study was conducted in 2015-2017 in patients affected by IEMRDs (except phenylketonuria) younger than 18 years. Data collection was based on medical records, clinical examinations, parents' and children's interviews, and self-reported questionnaires...
March 4, 2020: Journal of Pediatrics
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