Use the journals feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Daniel Pastor-Morate, Lidia Amigo-Morán, María Garranzo-Asensio, Raquel Rejas-González, Patricia Carnicero, Nuria Rodríguez, Juan Pedro Pérez-Robledo, Rodrigo Barderas, Isabel Prieto-Nieto, Gemma Domínguez
Peritoneal metastasis of colorectal origin appears in ~10-15% of patients at the time of diagnosis and in 30-40% of cases with disease progression. Locoregional spread through the peritoneum is considered stage IVc and is associated with a poor prognosis. The development of a regional therapeutic strategy based on cytoreductive surgery, and hyperthermic intra-abdominal chemotherapy has significantly altered the course of the disease. Although recent evidence supports the benefits of cytoreductive surgery, the benefits of hyperthermic intra-abdominal chemotherapy are, however, still a matter of debate...
April 17, 2024: Journal of Pathology
#2
JOURNAL ARTICLE
Marialetizia Motta, Sabina Barresi, Simone Pizzi, Delfina Bifano, Jennifer Lopez Marti, Marta Garrido-Pontnou, Elisabetta Flex, Alessandro Bruselles, Isabella Giovannoni, Giovannina Rotundo, Alessandra Fragale, Valentina Tirelli, Silvia Vallese, Andrea Ciolfi, Gianni Bisogno, Rita Alaggio, Marco Tartaglia
Infantile fibrosarcomas (IFS) and congenital mesoblastic nephroma (CMN) are rare myofibroblastic tumors of infancy and early childhood commonly harboring the ETV6::NTRK3 gene fusion. IFS/CMN are considered as tumors with an 'intermediate prognosis' as they are locally aggressive, but rarely metastasize, and generally have a favorable outcome. A fraction of IFS/CMN-related neoplasms are negative for the ETV6::NTRK3 gene rearrangement and are characterized by other chimeric proteins promoting MAPK signaling upregulation...
April 17, 2024: Journal of Pathology
#3
JOURNAL ARTICLE
Yanjiang Chen, Sabrina Steiner, Catherine Hagedorn, Sarah Kollar, Alicia Pliego-Mendieta, Martina Haberecker, Jan Plock, Christian Britschgi, Lara Planas-Paz, Chantal Pauli
Genomic rearrangements of the neurotrophic receptor tyrosine kinase genes (NTRK1, NTRK2, and NTRK3) are the most common mechanism of oncogenic activation for this family of receptors, resulting in sustained cancer cell proliferation. Several targeted therapies have been approved for tumours harbouring NTRK fusions and a new generation of TRK inhibitors has already been developed due to acquired resistance. We established a patient-derived LMNA::NTRK1-rearranged soft-tissue sarcoma cell model ex vivo with an acquired resistance to targeted TRK inhibition...
April 12, 2024: Journal of Pathology
#4
JOURNAL ARTICLE
Christina Sharkey, Xingbo Long, Ra'ad Al-Faouri, Douglas Strand, Aria F Olumi, Zongwei Wang
Steroid 5α reductase 2 (SRD5A2) converts testosterone to dihydrotestosterone and is crucial for prostatic development. 5α reductase inhibitors (5ARI) reduce prostate size in benign prostate hyperplasia (BPH) and ameliorate lower urinary tract symptoms secondary to BPH. However, the mechanisms of 5ARI functioning are still not fully understood. Here, we used a Srd5a2-/- mouse model and employed single-cell RNA sequencing to explore the impact of SRD5A2 absence on prostate cellular heterogeneity. Significant alterations in luminal epithelial cell (LE) populations were observed, alongside an increased proportion and proliferative phenotype of estrogen receptor 1 (ESR1)+ LE2 cells, following an SRD5A2-independent ESR1 differentiation trajectory...
April 12, 2024: Journal of Pathology
#5
JOURNAL ARTICLE
Shohei Yoshimoto, Naomi Yada, Ayataka Ishikawa, Kenji Kawano, Kou Matsuo, Akimitsu Hiraki, Kazuhiko Okamura
Necrotising sialometaplasia (NSM) is a non-neoplastic lesion mainly arising in the minor salivary glands of the oral cavity. In the clinical features, NSM shows swelling with or without ulceration, and can mimic a malignant disease such as squamous cell carcinoma. Histopathologically, NSM usually shows the lobular architecture that is observed in the salivary glands. Additionally, acinar infarction and squamous metaplasia of salivary ducts and acini are observable. The aetiology of this lesion remains unknown, although it has a characteristic feature that sometimes requires clinical and histopathological differentiation from malignancy...
April 9, 2024: Journal of Pathology
#6
JOURNAL ARTICLE
Lawrence H Lin, Brooke E Howitt, David L Kolin
Mesonephric adenocarcinomas (MAs) and mesonephric-like adenocarcinomas (MLAs) are rare, aggressive neoplasms that arise in the gynecologic tract and show overlapping morphologic, immunohistochemical, and molecular features. While MAs occur in the cervix and are thought to arise from mesonephric remnants, MLAs occur in the endometrium and ovary and are believed to originate from transdifferentiation of Müllerian lesions. Both MAs and MLAs show a variety of architectural patterns, exhibit frequent expression of GATA3 by immunohistochemistry, and harbor KRAS mutations...
April 9, 2024: Journal of Pathology
#7
JOURNAL ARTICLE
Nicholas Choo, Shivakumar Keerthikumar, Susanne Ramm, Daisaku Ashikari, Linda Teng, Birunthi Niranjan, Shelley Hedwards, Laura H Porter, David L Goode, Kaylene J Simpson, Renea A Taylor, Gail P Risbridger, Mitchell G Lawrence
There are diverse phenotypes of castration-resistant prostate cancer, including neuroendocrine disease, that vary in their sensitivity to drug treatment. The efficacy of BET and CBP/p300 inhibitors in prostate cancer is attributed, at least in part, to their ability to decrease androgen receptor (AR) signalling. However, the activity of BET and CBP/p300 inhibitors in prostate cancers that lack the AR is unclear. In this study, we showed that BRD4, CBP, and p300 were co-expressed in AR-positive and AR-null prostate cancer...
April 5, 2024: Journal of Pathology
#8
JOURNAL ARTICLE
Jooske L Monster, Lars Js Kemp, Georg A Busslinger, Marjolein J Vliem, Lucca Lm Derks, Annelot Al Staes, Tanya M Bisseling, Hans Clevers, Rachel S van der Post, Martijn Gloerich
Loss of the cell-cell adhesion protein E-cadherin underlies the development of diffuse-type gastric cancer (DGC), which is characterized by the gradual accumulation of tumor cells originating from the gastric epithelium in the surrounding stroma. How E-cadherin deficiency drives DGC formation remains elusive. Therefore, we investigated the consequences of E-cadherin loss on gastric epithelial organization utilizing a human gastric organoid model and histological analyses of early-stage DGC lesions. E-cadherin depletion from gastric organoids recapitulates DGC initiation, with progressive loss of a single-layered architecture and detachment of individual cells...
April 4, 2024: Journal of Pathology
#9
JOURNAL ARTICLE
Tatjana Geukens, Marion Maetens, Jody E Hooper, Steffi Oesterreich, Adrian V Lee, Lori Miller, Jenny M Atkinson, Margaret Rosenzweig, Shannon Puhalla, Heather Thorne, Lisa Devereux, David Bowtell, Sherene Loi, Eliza R Bacon, Kena Ihle, Mihae Song, Lorna Rodriguez-Rodriguez, Alana L Welm, Lisa Gauchay, Rajmohan Murali, Pharto Chanda, Ali Karacay, Cristina Naceur-Lombardelli, Hayley Bridger, Charles Swanton, Mariam Jamal-Hanjani, Lori Kollath, Lawrence True, Colm Morrissey, Meagan Chambers, Arul M Chinnaiyan, Allecia Wilson, Rohit Mehra, Zachery Reichert, Lisa A Carey, Charles M Perou, Erin Kelly, Daichi Maeda, Akiteru Goto, Janina Kulka, Borbála Székely, A Marcell Szasz, Anna-Mária Tőkés, Wouter Van Den Bogaert, Giuseppe Floris, Christine Desmedt
While there is a great clinical need to understand the biology of metastatic cancer in order to treat it more effectively, research is hampered by limited sample availability. Research autopsy programmes can crucially advance the field through synchronous, extensive, and high-volume sample collection. However, it remains an underused strategy in translational research. Via an extensive questionnaire, we collected information on the study design, enrolment strategy, study conduct, sample and data management, and challenges and opportunities of research autopsy programmes in oncology worldwide...
March 29, 2024: Journal of Pathology
#10
JOURNAL ARTICLE
Shan Shan, Xinyan Zhao, Michelle A Wood-Trageser, Doudou Hu, Liwei Liu, Beining Qi, Jianbo Jian, Ping Wang, Wenjuan Lv, Chunhong Hu
The effects of the obliteration of portal venules (OPV) in cirrhotic portal hypertension are poorly understood. To investigate its contribution to portal hypertension in biliary cirrhosis and its underlying mechanism, we evaluated OPV using two-dimensional (2D) histopathology in liver explants from patients with biliary atresia (BA, n = 63), primary biliary cholangitis (PBC, n = 18), and hepatitis B-related cirrhosis (Hep-B-cirrhosis, n = 35). Then, three-dimensional (3D) OPV was measured by X-ray phase-contrast CT in two parallel models in rats following bile duct ligation (BDL) or carbon tetrachloride (CCl4 ) administration, representing biliary cirrhosis and post-necrotic cirrhosis, respectively...
March 29, 2024: Journal of Pathology
#11
JOURNAL ARTICLE
Willemijn de Klaver, Meike de Wit, Anne Bolijn, Marianne Tijssen, Pien Delis-van Diemen, Margriet Lemmens, Manon Cw Spaander, Evelien Dekker, Monique E van Leerdam, Veerle Mh Coupé, Ruben van Boxtel, Hans Clevers, Beatriz Carvalho, Gerrit A Meijer
Environmental factors like the pathogenicity island polyketide synthase positive (pks+) Escherichia coli (E. coli) could have potential for risk stratification in colorectal cancer (CRC) screening. The association between pks+ E. coli measured in fecal immunochemical test (FIT) samples and the detection of advanced neoplasia (AN) at colonoscopy was investigated. Biobanked FIT samples were analyzed for both presence of E. coli and pks+ E. coli and correlated with colonoscopy findings; 5020 CRC screening participants were included...
March 29, 2024: Journal of Pathology
#12
JOURNAL ARTICLE
Liao Peng, Jia-Wei Chen, Yuan-Zhuo Chen, Chi Zhang, Si-Hong Shen, Meng-Zhu Liu, Yang Fan, Shi-Qin Yang, Xiu-Zhen Zhang, Wei Wang, Xiao-Shuai Gao, Xing-Peng Di, Yu-Cheng Ma, Xiao Zeng, Hong Shen, Xi Jin, De-Yi Luo
Urothelial damage and barrier dysfunction emerge as the foremost mechanisms in Hunner-type interstitial cystitis/bladder pain syndrome (HIC). Although treatments aimed at urothelial regeneration and repair have been employed, their therapeutic effectiveness remains limited due to the inadequate understanding of specific cell types involved in damage and the lack of specific molecular targets within these mechanisms. Therefore, we harnessed single-cell RNA sequencing to elucidate the heterogeneity and developmental trajectory of urothelial cells within HIC bladders...
March 29, 2024: Journal of Pathology
#13
JOURNAL ARTICLE
Xiao Li, Jeffrey Eastham, Jennifer M Giltnane, Wei Zou, Andries Zijlstra, Evgeniy Tabatsky, Romain Banchereau, Ching-Wei Chang, Barzin Y Nabet, Namrata S Patil, Luciana Molinero, Steve Chui, Maureen Harryman, Shari Lau, Linda Rangell, Yannick Waumans, Mark Kockx, Darya Orlova, Hartmut Koeppen
Cancer immunotherapy has transformed the clinical approach to patients with malignancies, as profound benefits can be seen in a subset of patients. To identify this subset, biomarker analyses increasingly focus on phenotypic and functional evaluation of the tumor microenvironment to determine if density, spatial distribution, and cellular composition of immune cell infiltrates can provide prognostic and/or predictive information. Attempts have been made to develop standardized methods to evaluate immune infiltrates in the routine assessment of certain tumor types; however, broad adoption of this approach in clinical decision-making is still missing...
March 25, 2024: Journal of Pathology
#14
(no author information available yet)
No abstract text is available yet for this article.
March 21, 2024: Journal of Pathology
#15
JOURNAL ARTICLE
Hannah C Beird, Dimitri Lin, Alexander J Lazar, P Andrew Futreal
Gene disruption from double-strand DNA breaks within introns is a mechanism of inactivating the tumor suppressor TP53. This occurs more frequently in osteosarcoma and biliary adenocarcinoma compared with other cancer types. The patterns of intron breakpoints within TP53 do not correlate with prevalence, intron length, or overall genome-wide levels of rearrangements. Therefore, these breakpoints appear to be selected for reasons other than to disrupt TP53. A recent article published by Saba et al in The Journal of Pathology illustrates a benefit to having breakpoints within intron 1 using high-quality matched genomic and transcriptomic osteosarcoma sequencing data as well as in vitro validation...
March 14, 2024: Journal of Pathology
#16
JOURNAL ARTICLE
Yuko Omori, Shuichi Aoki, Yusuke Ono, Takashi Kokumai, Shingo Yoshimachi, Hideaki Sato, Akiko Kusaka, Masahiro Iseki, Daisuke Douchi, Takayuki Miura, Shimpei Maeda, Masaharu Ishida, Masamichi Mizuma, Kei Nakagawa, Yusuke Mizukami, Toru Furukawa, Michiaki Unno
The molecular mechanisms underpinning the development of metachronous tumors in the remnant bile duct following surgical resection of primary biliary tract carcinomas (BTCs) are unknown. This study aimed to elucidate these mechanisms by evaluating the clinicopathologic features of BTCs, the alterations to 31 BTC-related genes on targeted sequencing, and the aberrant expression of p53, p16, SMAD4, ARID1A and β-catenin on immunohistochemistry. Twelve consecutive patients who underwent resection of metachronous BTCs following primary BTC resection with negative bile duct margins were enrolled...
March 14, 2024: Journal of Pathology
#17
(no author information available yet)
No abstract text is available yet for this article.
March 13, 2024: Journal of Pathology
#18
JOURNAL ARTICLE
Haowen Zhou, Mark Watson, Cory T Bernadt, Steven Siyu Lin, Chieh-Yu Lin, Jon H Ritter, Alexander Wein, Simon Mahler, Sid Rawal, Ramaswamy Govindan, Changhuei Yang, Richard J Cote
Brain metastases can occur in nearly half of patients with early and locally advanced (stage I-III) non-small cell lung cancer (NSCLC). There are no reliable histopathologic or molecular means to identify those who are likely to develop brain metastases. We sought to determine if deep learning (DL) could be applied to routine H&E-stained primary tumor tissue sections from stage I-III NSCLC patients to predict the development of brain metastasis. Diagnostic slides from 158 patients with stage I-III NSCLC followed for at least 5 years for the development of brain metastases (Met+ , 65 patients) versus no progression (Met- , 93 patients) were subjected to whole-slide imaging...
March 4, 2024: Journal of Pathology
#19
JOURNAL ARTICLE
Yin-Qiao Liu, Yi-Wei Xu, Zheng-Tan Zheng, Die Li, Chao-Qun Hong, Hao-Qiang Dai, Jun-Hao Wang, Ling-Yu Chu, Lian-Di Liao, Hai-Ying Zou, En-Min Li, Jian-Jun Xie, Wang-Kai Fang
Desmoglein-2 (DSG2) is a transmembrane glycoprotein belonging to the desmosomal cadherin family, which mediates cell-cell junctions; regulates cell proliferation, migration, and invasion; and promotes tumor development and metastasis. We previously showed serum DSG2 to be a potential biomarker for the diagnosis of esophageal squamous cell carcinoma (ESCC), although the significance and underlying molecular mechanisms were not identified. Here, we found that DSG2 was increased in ESCC tissues compared with adjacent tissues...
February 27, 2024: Journal of Pathology
#20
JOURNAL ARTICLE
Da-Jia Li, Yin-Wei Cheng, Jin-Mei Pan, Zhen-Chang Guo, Shao-Hong Wang, Qing-Feng Huang, Ping-Juan Nie, Wen-Qi Shi, Xiu-E Xu, Bing Wen, Jin-Ling Zhong, Zhi-Da Zhang, Zhi-Yong Wu, Hui Zhao, Lian-Di Liao, Jian-Yi Wu, Kai Zhang, Geng Dong, En-Min Li, Li-Yan Xu
Fascin actin-bundling protein 1 (Fascin) is highly expressed in a variety of cancers, including esophageal squamous cell carcinoma (ESCC), working as an important oncogenic protein and promoting the migration and invasion of cancer cells by bundling F-actin to facilitate the formation of filopodia and invadopodia. However, it is not clear how exactly the function of Fascin is regulated by acetylation in cancer cells. Here, in ESCC cells, the histone acetyltransferase KAT8 catalyzed Fascin lysine 41 (K41) acetylation, to inhibit Fascin-mediated F-actin bundling and the formation of filopodia and invadopodia...
February 27, 2024: Journal of Pathology
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
