Kansuke Kido, Satoshi Nojima, Daisuke Motooka, Yusuke Nomura, Masaharu Kohara, Kazuaki Sato, Kenji Ohshima, Shinichiro Tahara, Masako Kurashige, Daisuke Umeda, Tsuyoshi Takashima, Hiroki Kiyokawa, Koto Ukon, Takahiro Matsui, Daisuke Okuzaki, Eiichi Morii
Platinum resistance is a major obstacle to the treatment of ovarian cancer and is correlated with poor clinical outcomes. Intratumor heterogeneity plays a key role in chemoresistance. Recent studies have emphasized the contributions of genetic and epigenetic factors to the development of intratumor heterogeneity. Although the clinical significance of multisubunit chromatin remodeler, switch/sucrose nonfermenting (SWI/SNF) complexes in cancers has been reported, the impacts of SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4/subfamily A, member 2 (SMARCA4/A2) expression patterns in human cancer tissues have not been fully elucidated...
February 10, 2023: Journal of Pathology