Samantha Morón-Ros, Albert Blasco-Roset, Artur Navarro-Gascon, Celia Rupérez, Monica Zamora, Fatima Crispi, Iker Uriarte, Maite G Fernández-Barrena, Matias Avila, Gemma Ferrer-Curriu, Josep Lupón, Antoni Bayés-Genis, Francesc Villarroya, Aleix Gavaldà-Navarro, Anna Planavila
FGF15 and its human orthologue, FGF19, are members of the endocrine FGF family and are secreted by ileal enterocytes in response to bile acids. FGF15/19 mainly targets the liver, but recent studies indicate that it also regulates skeletal muscle mass and adipose tissue plasticity. The aim of this study was to determine the role(s) of the enterokine FGF15/19 during the development of cardiac hypertrophy. Studies in a cohort of humans suffering from heart failure showed increased circulating levels of FGF19 compared with control individuals...
August 31, 2023: Journal of Pathology