Riccardo LoMartire, Örjan Dahlström, Mathilda Björk, Linda Vixner, Paolo Frumento, Lea Constan, Björn Gerdle, Björn Olov Äng
Chronic pain-related sickness absence is an enormous socioeconomic burden globally. Optimized interventions are reliant on a lucid understanding of the distribution of social insurance benefits and their predictors. This register-based observational study analyzed data for a seven-year period from a population-based sample of 44,241 chronic pain patients eligible for interdisciplinary treatment (IDT) at specialist clinics. Sequence analysis was used to describe the sickness absence over the complete period and to separate the patients into subgroups based on their social insurance benefits over the final two years...
April 2, 2021: Journal of Pain
Parker A Kell, Natalie Hellman, Felicitas A Huber, Edward W Lannon, Bethany L Kuhn, Cassandra A Sturycz, Tyler A Toledo, Mara J Demuth, Burkhart J Hahn, Joanna O Shadlow, Jamie L Rhudy
Adverse life events (ALEs) are a risk factor for chronic pain; however, mechanisms underlying this association are not understood. This study examined whether cumulative ALE exposure impairs endogenous inhibition of pain (assessed from pain report) and spinal nociception (assessed from nociceptive flexion reflex; NFR) in healthy, pain-free Native Americans (n=124) and non-Hispanic Whites (n=129) during a conditioned pain modulation (CPM) task. Cumulative ALE exposure was assessed prior to testing by summing the number of potentially traumatic events experienced by each participant across their lifespan...
April 2, 2021: Journal of Pain
Megan L Falsetta, Ronald W Wood, Mitchell A Linder, Adrienne D Bonham, Kenneth V Honn, Krishna Rao Maddipati, Richard P Phipps, Constantine G Haidaris, David C Foster
Localized provoked vulvodynia (LPV) is the most common cause of chronic dyspareunia in premenopausal women, characterized by pain with light touch to the vulvar vestibule surrounding the vaginal opening. The devastating impact of LPV includes sexual dysfunction, infertility, depression, and even suicide. Yet, its etiology is unclear. No effective medical therapy exists; surgical removal of the painful vestibule is the last resort. In LPV, the vestibule expresses a unique inflammatory profile with elevated levels of pro-nociceptive proinflammatory mediators prostaglandin E2 (PGE2 ) and interleukin-6 (IL-6), which are linked to lower mechanical sensitivity thresholds...
April 1, 2021: Journal of Pain
Sarah Nelson, Jaimie K Beveridge, Richelle Mychasiuk, Melanie Noel
The aims of this longitudinal study were to 1) identify categories of adverse childhood experiences (ACEs) (i.e., neglect, abuse, household dysfunction in childhood) that increase risk for internalizing mental health problems, pain-related impairment, and poorer quality of life and 2) examine the moderating role of posttraumatic stress symptoms (PTSS) in these associations, in a clinical sample of youth with chronic pain. At two timepoints, youth (N=155; aged 10-18 years) completed measures of exposure to ACEs, PTSS, depressive and anxiety symptoms, pain intensity, pain interference, and quality of life...
March 30, 2021: Journal of Pain
Jonathan Paulo Agnes, Vitória Wibbelt Dos Santos, Raquel Nascimento das Neves, Rosângela Mayer Gonçalves, Marina Delgobo, Carolina Saibro Girardi, Débora Denardin Lückemeyer, Marcella de Amorim Ferreira, Sérgio José Macedo Júnior, Samantha Cristiane Lopes, Fernando Spiller, Daniel Pens Gelain, José Cláudio Fonseca Moreira, Rui Daniel Prediger, Juliano Ferreira, Alfeu Zanotto-Filho
Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a common, difficult-to-treat, and dose-limiting side effect associated with Oxaliplatin (OXA) treatment. In this study, we evaluated the effect of three antioxidants - namely N-acetylcysteine, α-lipoic acid and vitamin E - upon nociceptive parameters and antitumor efficacy of OXA in a tumor-bearing Swiss mice model. Oral treatment with antioxidants inhibited both mechanical and cold allodynia when concomitantly administrated with OXA (preventive protocol), as well as in animals with previously established CIPN (therapeutic protocol)...
March 24, 2021: Journal of Pain
Rui Li, Donna A Kreher, Todd A Jusko, Benjamin P Chapman, Adrienne D Bonham, Christopher L Seplaki
Despite emerging evidence of associations between dysmenorrhea, enhanced pain sensitivity, and functional neuroimaging patterns consistent with chronic pain, it is unknown whether dysmenorrhea is prospectively associated with chronic pain development. Gaining a better understanding of this relationship could inform efforts in prevention of chronic pain. Using data from the national Midlife in the United States cohort, we examined the prospective association between dysmenorrhea and chronic pain development during a 10-year follow-up (starting 10 years after dysmenorrhea was measured) among 874 community-dwelling women aged 25-74 at baseline (when dysmenorrhea was measured)...
March 21, 2021: Journal of Pain
Carolyn Berryman, Sarah B Wallwork, Alberto Marcos Heredia Rizo, Emma Knight, Danny Camfferman, Leslie Russek, G Lorimer Moseley
The purpose of the current study was to determine whether auditory prepulse inhibition (PPI) and/or prepulse facilitation (PPF) were altered in people with fibromyalgia (FM) when compared with controls. Eyeblink responses were recorded from 29 females with FM and 27 controls, while they listened to three blocks of auditory stimuli that delivered pulses with either PPI or PPF. Using a linear mixed model, our main findings were that there was a GROUP*CONDITION interaction (F4, 1084  = 4.01, p = .0031) indicating that the difference in amplitude between FM group and control group changed depending on the condition (PPI or PPF)...
March 20, 2021: Journal of Pain
Philip M Procento, Kevin L Rand, Jesse C Stewart, Adam T Hirsh
The bidirectional relationship between pain and working memory (WM) deficits is well-documented but poorly understood. Pain catastrophizing - exaggerated, negative cognitive and emotional responses toward pain - may contribute to WM deficits by occupying finite, shared cognitive resources. The present study assessed the role of pain catastrophizing as both a state-level process and trait-level disposition in the link between acute pain and WM. Healthy, young adults were randomized to an experimentally-induced ischemic pain or control task, during which they completed verbal and non-verbal WM tests...
March 13, 2021: Journal of Pain
Jeremy Dunford, Andrea T Lee, Michael M Morgan
Inflammatory Bowel Disease (IBD) is a life-long disorder that often begins between the ages of 15 and 30. Anecdotal reports suggest cannabinoids may be an effective treatment. This study sought to determine whether home cage wheel running is an effective method to assess IBD, and whether THC, the primary psychoactive compound in cannabis, can restore wheel running depressed by IBD. Adolescent and adult female Sprague-Dawley rats were individually housed in a cage with a running wheel. Rats were injected with trinitrobenzene sulphonic acid (TNBS) into the rectum to induce IBD-like symptoms...
March 13, 2021: Journal of Pain
Raymond C Tait, John T Chibnall, Donna Kalauokalani
While patient perceptions of burden to caregivers is of recognized clinical significance among people with chronic pain, perceived burden to treating physicians has not been studied. This study examined how people with chronic pain perceived levels of medical evidence (low vs high) and pain severity (4,6,8/10) to influence physician burden and how burden then mediated expected clinical judgments. 476 people with chronic pain read vignettes describing a hypothetical patient with varying levels of medical evidence and pain severity from the perspective of a treating physician, rated the burden that patient care would pose, and made a range of clinical judgments...
March 13, 2021: Journal of Pain
Lanlan Zhang, Elizabeth A Reynolds Losin, Yoni K Ashar, Leonie Koban, Tor D Wager
Caregiving and other interpersonal interactions often require accurate perception of others' pain from nonverbal cues, but perceivers may be subject to systematic biases based on gender, race, and other contextual factors. Such biases could contribute to systematic under-recognition and under-treatment of pain. In two experiments, we studied the impact of perceived patient sex on lay perceivers' pain estimates and treatment recommendations. In Experiment 1 (N = 50), perceivers viewed facial video clips of female and male patients in chronic shoulder pain and estimated patients' pain intensity...
March 5, 2021: Journal of Pain
Caroline Maindet, Aurore Maire, Céline Vermorel, Claire Cracowski, Carole Rolland, Romain Forestier, Alexa Comte, Christian-François Roques, Eric Serra, Jean Luc Bosson
Fibromyalgia is a common chronic pain pathology with an incidence of 4.3 per 1000 person-years. An open, randomized clinical trial of patients with fibromyalgia comparing an immediate vs. delayed 18-day spa therapy in five spa therapy care facilities in France enrolled 220 patients. Randomization was in blocks of four, stratified by center, severity of fibromyalgia and previous spa therapy. Patients continued usual treatment. The main endpoint was the number of patients achieving minimal clinically important difference (MCID) at 6 months, defined as 14% change in their baseline fibromyalgia impact questionnaire (FIQ) score...
March 4, 2021: Journal of Pain
Lin Yu, Kitty Kioskli, Lance M McCracken
AIMS: People with chronic pain may be particularly vulnerable to the impact of the pandemic COVID-19, and psychological flexibility may protect them. This study investigates psychological functioning in the context of COVID-19, including fear and avoidance in the context of COVID-19, specifically its association with daily functioning, and the role of psychological flexibility, among people with chronic pain. METHODS: Responses from 555 adults with chronic pain were collected through a cross-sectional online survey and analysed...
March 4, 2021: Journal of Pain
Jiajie Lu, Xiaoning Guo, Manyun Yan, Xiaqing Yuan, Shujun Chen, Yiqing Wang, Juehua Zhu, Shicun Huang, Haitao Shen, Haiying Li, Qun Xue, Qi Fang, Jianqiang Ni, Lei Gan, Hongru Zhao, Haifeng Lu, Gang Chen
Central post-stroke pain (CPSP) is a disabling condition in stroke patients. It is a type of neuropathic pain for which the mechanism and relevant drug pathways remain unknown. Inflammatory response and central disinhibition have been suggested recently. Our previous research has shown targeting P2X4R may be effective in the treatment of CPSP, but the downstream pathway of the P2X4R has not been studied. In this study, we found the increase in TNF-α level and endocytosis of surface GABAaR in CPSP, and these effects were inhibited by blocking P2X4R...
March 4, 2021: Journal of Pain
Megan E McPhee, Thomas Graven-Nielsen
Chronic low back pain (CLBP) is highly disabling, but often without identifiable source. Focus has been on impaired anti-nociceptive mechanisms contributing to pain maintenance, though methods of targeting this impairment remain limited. This randomised-controlled cross-over pilot trial used active versus sham medial prefrontal cortex (mPFC) high-definition transcranial direct current stimulation (HD-tDCS) for three-consecutive days to improve descending pain inhibitory function. Twelve CLBP patients were included with an average visual analogue scale (VAS) pain intensity of 3...
March 3, 2021: Journal of Pain
Isabelle Rouch, Jean-Michel Dorey, Marie-Pierre F Strippoli, Mehdi Gholam, Pedro Marques-Vidal, Bernard Laurent, Armin von Gunten, Martin Preisig
Chronic pain (CP) and cognitive impairment are common in older adults. CP was found to be associated with cognitive impairment in many cross-sectional studies. However, their cross-sectional design precluded inference on temporality. Accordingly, we aimed to prospectively assess the association between cognitive functioning and the occurrence of CP in older community dwellers. Analyses were based on data of the first (FU1) and the second follow-up (FU2) of CoLaus|PsyCoLaus, a prospective cohort study conducted in the general population of Lausanne (Switzerland) including the participants aged 65 and over...
February 25, 2021: Journal of Pain
Pedro Alvarez, Oliver Bogen, Paul G Green, Jon D Levine
Adult rats previously submitted to neonatal limited bedding (NLB), a model of early-life stress, display muscle mechanical hyperalgesia and nociceptor hyperexcitability, the underlying mechanism for which is unknown. Since voltage-gated sodium channel subtype 7 (NaV 1.7) contributes to mechanical hyperalgesia in several preclinical pain models and is critical for nociceptor excitability, we explored its role in the muscle hyperalgesia exhibited by adult NLB rats. Western blot analyses demonstrated increased NaV 1...
February 24, 2021: Journal of Pain
Richard L Nahin
We provide national surveillance estimates of pain chronicity, severity and impact in adult subpopulations defined by both Hispanic Ancestry and Race. Data are from 144,434 adults who completed validated questionnaires in the 2010-2017 National Health Interview Survey asking about pain status within the last three (n=84,664) or six months (n=59,770). Multivariable logistic regression was used to assess the relationship between pain and ethnicity/race. Compared to White Puerto Rican participants, White participants with Central/South American and Mexican ancestry had reduced odds of reporting Category 3-4 pain and High-Impact Chronic Pain (HICP), while those of Cuban ancestry had reduced odds of only HICP - e...
February 23, 2021: Journal of Pain
Jorge Sánchez-Infante, Alfredo Bravo-Sánchez, Fernando Jiménez, Javier Abián-Vicén
The aim of this study was to analyze the effects of dry needling (DN) in upper trapezius latent trigger points (LTrPs) on muscle stiffness. A total of 51 recreational physically active subjects with LTrPs in the upper trapezius volunteered to participate and were randomly divided into a DN-group (n = 27) and a sham-DN group (n = 24). Volunteers received 1-session of DN or placebo treatment. Muscle stiffness, measured with strain and shear-wave elastography, pressure pain threshold (PPT), post-needling soreness, and muscle thickness were evaluated before treatment, and at 30-min, 24-hours, and 72-hours follow-up after treatment...
February 23, 2021: Journal of Pain
Xianchen Liu, Zhen-Zhen Liu, Yanyun Yang, Cun-Xian Jia
Chronic pain and suicidal behavior are prevalent in adolescents. This longitudinal study examined the associations between pain symptoms and suicidal behavior in adolescents. A total of 7,072 adolescents participated in a follow-up study of behavior and health in Shandong, China. A self-administered structured questionnaire was used to assess pain symptoms (headache, stomachache, and other nonspecific pain), insomnia, anxiety/depression, substance use, stressful life events, prior suicidal behavior, and family environment in November-December in 2015...
February 23, 2021: Journal of Pain
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"