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Journal of Pain

Daniel Whibley, Tiffany J Braley, Anna L Kratz, Susan L Murphy ScD
Poor sleep quality has been associated with greater pain and fatigue in people living with osteoarthritis (OA). The objective of this micro-longitudinal study was to determine whether sleep impacts the diurnal pattern of next-day OA-related pain and fatigue. Community dwelling older adults (≥65 years) with hip and/or knee OA provided data over five days using daily diaries and wrist-worn actigraphs. Pain and fatigue intensity were measured on awakening, at 11am, 3pm, 7pm and bedtime. Subjective previous-night sleep quality was measured on awakening only...
May 11, 2019: Journal of Pain: Official Journal of the American Pain Society
Jian-Ling Gao, Ke Peng, Meng-Wei Shen, Yong-Heng Hou, Xiao-Bo Qian, Xiao-Wen Meng, Fu-Hai Ji, Li-Na Wang, Jian-Ping Yang
Our preliminary experiment indicated the activation of with-nolysine kinases 1 (WNK1) in bone cancer pain (BCP) rats. This study aimed to investigate the underlying mechanisms via which WNK1 contributed to BCP. A rat model of BCP was induced by Walker-256 tumor cell implantation. WNK1 expression and distribution in the lumbar spinal cord dorsal horn (DH) and dorsal root ganglion (DRG) were examined. SPS1-related proline/alanine-rich kinase (SPAK), oxidative stress-responsive kinase 1 (OSR1), sodium-potassium-chloride cotransporter 1 (NKCC1), and potassium-chloride cotransporter 2 (KCC2) expression were assessed...
May 11, 2019: Journal of Pain
Wouter Schuller, Caroline B Terwee, Thomas Klausch, Leo D Roorda, Daphne C Rohrich, Raymond W Ostelo, Berend Terluin, Henrica C W de Vet
We studied the psychometric properties of the 39 item v1.1 Dutch-Flemish PROMIS Pain Behavior item bank in a sample of 1602 patients with musculoskeletal complaints. We evaluated the assumptions of the underlying Item Response Theory (IRT) model (unidimensionality and local dependency with Confirmatory Factor Analyses (CFA), and monotonicity with scalability coefficients). We studied IRT-model fit of all items, and estimated the item parameters of the IRT model. Differential Item Functioning (DIF) was studied for age and gender, and DIF for language was studied as a measure of cross-cultural validity...
May 9, 2019: Journal of Pain
Dennis Boye Larsen, Thomas Graven-Nielsen, Shellie Ann Boudreau
Musculoskeletal pain reduces corticomotor excitability (CE) and methods modulating such CE reduction remain elusive. This study aimed to modulate pain-induced CE reduction by performing action observation and motor imagery (AOMI) during experimental muscle pain. Twelve healthy subjects participated in three cross-over and randomized sessions separated by one week. During the AOMI session subjects performed an AOMI task for 10 mins. In the AOMI+PAIN session, hypertonic saline was injected in the first dorsal interosseous (FDI) muscle prior to performing the AOMI task...
May 8, 2019: Journal of Pain: Official Journal of the American Pain Society
David J Moore, Samantha M Meints, Asimina Lazaridou, Devin Johnson, Olivia Franceschelli, Marise Cornelius, Kristin Schreiber, Robert R Edwards
Pain has well established effects on attention. At present parallel literatures exist which have examined the effects of experimentally induced pain and consider cognitive performance in patients with chronic pain states. However, no study to date as attempted to examine the combined or differing effects of these two manifestations of pain in a single study. 24 participants with fibromyalgia (age 43.00, SD 28.28) and 26 healthy controls (age=36.07 SD=11.93) completed an n-back task, an attentional switching task, and a divided attention task, once during induced, moderately-intense pressure pain, and once without induced pain...
May 8, 2019: Journal of Pain: Official Journal of the American Pain Society
Kahkashan Resham, Shyam S Sharma
Wnt signaling pathway has been investigated extensively for its diverse metabolic and pain modulating mechanisms and recently its involvement has been postulated in the development of neuropathic pain. However, there are no reports as yet on involvement of Wnt signaling pathway in one of the most debilitating neurovascular complication of diabetes, i.e, diabetic peripheral neuropathy (DPN). Thus, in the present study, involvement of Wnt signaling was investigated in DPN using Wnt signaling inhibitors namely LGK974 (Porcupine inhibitor), NSC668036 (Disheveled inhibitor) and PNU74654 (β-catenin inhibitor)...
May 7, 2019: Journal of Pain
Patricia M Herman, Jill E Luoto, Mallika Kommareddi, Melony E Sorbero, Ian D Coulter
Many recommended nonpharmacologic therapies for patients with chronic spinal pain require visits to providers such as acupuncturists and chiropractors. Little information is available to inform third-party payers' coverage policies regarding ongoing use of these therapies. This study offers contingent valuation-based estimates of patient willingness-to-pay (WTP) for pain reductions from a large (n=1583) sample of patients using ongoing chiropractic care to manage their chronic low-back and neck pain. Average WTP estimates were $45...
May 6, 2019: Journal of Pain: Official Journal of the American Pain Society
Javier Martinez-Calderon, Mar Flores-Cortes, Jose Miguel Morales-Asencio, Alejandro Luque-Suarez
Pain-related fear is considered a strong psychological predictor for both chronic pain and disability. The aims of this study were to systematically review and critically appraise the concurrent association and the predictive value of pain-related fear affecting both pain intensity and disability in individuals with chronic musculoskeletal pain. PubMed, AMED, CINAHL, PsycINFO, PubPsych and grey literature were searched from inception to January 2019. Observational studies reporting cross-sectional and longitudinal associations between pain-related fear and pain intensity and/or disability were included...
May 4, 2019: Journal of Pain: Official Journal of the American Pain Society
Maria N Wilson, Jill A Hayden, Emily Rhodes, Alysia Robinson, Mark Asbridge
Prescription monitoring programs (PMPs) house and monitor data about the prescribing practices of healthcare providers, as well as medications received by patients. PMPs aim to promote the appropriate use of prescription opioids by providing this information to prescribers and dispensers. Our objective in this systematic review was to comprehensively identify and assess the available evidence about the impact of PMPs on opioid prescribing and dispensing, multiple provider use for obtaining opioids, inappropriate opioid prescribing, and the extent of non-medical prescription opioid use...
May 3, 2019: Journal of Pain: Official Journal of the American Pain Society
Rajesh Khanna, Amol Patwardhan, Xiaofang Yang, Wennan Li, Song Cai, Yingshi Ji, Lindsey A Chew, Angie Dorame, Shreya S Bellampalli, Ryan W Schmoll, Janalee Gordon, Aubin Moutal, Todd W Vanderah, Frank Porreca, Mohab M Ibrahim
We report the development and characterization of a novel, injury-free rat model in which nociceptive sensitization following red light is observed in multiple body areas reminiscent of widespread pain in functional pain syndromes. Rats were exposed to red light emitting diodes (RLED) (LEDs, 660 nanometer) at an intensity of 50 Lux for 8 hours daily for 5 days resulting in time- and dose-dependent thermal hyperalgesia and mechanical allodynia in both male and female rats. Females showed earlier onset of mechanical allodynia than males...
May 2, 2019: Journal of Pain
Benjamin P Van Dyke, Andrea K Newman, Calia A Moraís, John W Burns, Joshua C Eyer, Beverly E Thorn
Differences among patients can moderate the impact of evidence-based treatments (i.e., heterogeneity of treatment effects), leading patients to get more or less benefit. The Learning About My Pain (LAMP) study was a randomized comparative effectiveness trial of 10-week literacy-adapted group cognitive-behavioral therapy for chronic pain (CBT) vs. pain psychoeducation groups (EDU) vs. usual medical care (UC). We examined potential sociodemographic and cognitive moderators of treatment effect among participants with post-treatment assessments (N = 241)...
April 22, 2019: Journal of Pain: Official Journal of the American Pain Society
Sabine C Herpertz, Mike M Schmitgen, Christine Fuchs, Corinna Roth, Robert Christian Wolf, Katja Bertsch, Herta Flor, Valery Grinevich, Sabrina Boll
There is an ongoing debate whether the neuropeptide oxytocin (OT) modulates pain processing in humans. This study differentiates behavioral and neuronal OT effects on pain perception and pain anticipation by using a Pavlovian conditioning paradigm. Forty-six males received intranasally administered OT in a randomized double-blind, placebo-controlled group design. Although OT exerted no direct effect on perceived pain, OT was found to modulate the blood-oxygen-level-dependent response in the ventral striatum for painful versus warm unconditioned stimuli (US) and to decrease activity in the anterior insula with repeated thermal pain stimuli...
April 19, 2019: Journal of Pain: Official Journal of the American Pain Society
John A Zebala, Shawn L Searle, Lynn R Webster, Matt S Johnson, Aaron D Schuler, Dean Y Maeda, Stuart J Kahn
Desmetramadol is an investigational analgesic consisting of (+) and (-) enantiomers of the tramadol metabolite O-desmethyltramadol (M1). Tramadol is racemic and exerts analgesia by monoaminergic effects of (-)-tramadol and (-)-M1, and by the opioid (+)-M1. Tramadol labeling indicates CYP2D6 ultra-metabolizers can produce dangerous (+)-M1 levels, and CYP2D6 poor metabolizers insufficient (+)-M1 for analgesia. We hypothesized desmetramadol could provide the safety and analgesia of tramadol without its metabolic liabilities...
April 18, 2019: Journal of Pain: Official Journal of the American Pain Society
Catlin H Dennis, Denae S Clohessy, Amanda L Stone, Beth D Darnall, Anna C Wilson
Adverse childhood experiences (ACEs; e.g., parental divorce, physical or sexual abuse) are more prevalent in individuals with chronic pain compared to the general population. Both increased maternal ACEs and chronic pain have been associated with poor physical and emotional functioning in offspring. However, the mechanisms driving these associations are poorly understood. Thus, this cross-sectional study evaluated the relation between maternal ACEs, mothers' current functioning, and children's physical and emotional functioning in a sample of mothers with chronic pain and their 8-12 year-old children...
April 18, 2019: Journal of Pain: Official Journal of the American Pain Society
D W Wheeler, A Bhatia, V Mani, S Kinna, A Bell, Y Boyle, B A Chizh, D K Menon, M C Lee
Cutaneous mechanical hyperalgesia can be induced in healthy volunteers in early-phase analgesic studies to model central sensitization, a key mechanism of persistent pain. However, such hyperalgesia is short-lived (a matter of hours), and is used only for assessing only single drug doses. In contrast, post-surgical peri-incisional hyperalgesia may be more persistent, and hence be a more useful model for the assessment of the efficacy of new analgesics. We undertook quantitative sensory testing in 18 patients at peri-incisional and non-operated sites before open inguinal hernia repair and up to the 24th post-surgical week...
April 18, 2019: Journal of Pain: Official Journal of the American Pain Society
Richard Ohrbach, Samuel F Dworkin
The classification of temporomandibular disorders (TMD) has progressed substantially over the past 25 years due to the strategic implementation of an initial classification system based on core taxonomic principles. In this article we describe the development of the DC/TMD and its translation into the multidimensional ACTTION-American Pain Society Pain Taxonomy (AAPT) for chronic pain disorders. The initial scientific classification system (RDC/TMD) relied upon a boot-strapping process that did not attempt to solve all known clinical problems but, rather, focused on problems that could be solved at that time...
April 17, 2019: Journal of Pain: Official Journal of the American Pain Society
Lingling Sun, Yingying Lv, Jinge Tian, Tingting Yu, Fangfang Niu, Xin Zhang, Dongping Du
Accumulating evidence demonstrates the beneficial effects of physical exercise on pain conditions, however, the underlying mechanisms have not been thoroughly understood. The purpose of the present study was to investigate the effects of regular swimming exercise on neuroma pain and the possible roles of adipokines (leptin and adiponectin) in the pain behaviors modulated by exercise. The results showed that five weeks of regular swimming exercise relieved pain behaviors in a rat model of neuroma pain and normalized the dysregulation of circulating leptin and adiponectin in plasma induced by nerve injury...
April 12, 2019: Journal of Pain
Esme Fuller-Thomson, Lyndsey D Kotchapaw
Although there have been many studies on the link between chronic pain and suicidality, surprisingly little research has focused on resilience and recovery among those in chronic and disabling pain who have had suicidal thoughts. The objectives of this study were to identify the prevalence and correlates of recovery from suicidal thoughts among those in chronic pain. A secondary analysis of a nationally representative sample of Canadians in chronic and disabling pain who had ever had serious suicidal thoughts (N = 635) was conducted to identify the prevalence and characteristics of those who are no longer considering suicide...
April 9, 2019: Journal of Pain: Official Journal of the American Pain Society
John W Burns, Kristina M Post, David A Smith, Laura S Porter, Asokumar Buvanendran, Anne Marie Fras, Francis J Keefe
Patients' beliefs and perceptions about the causes and meaning of their chronic pain are related to their psychosocial functioning. Beliefs and perceptions about chronic pain held by spouses may also be related to patient functioning. We used a laboratory procedure to evaluate whether spouse beliefs about and perceptions of chronic pain were related to spouse negative responses toward chronic low back pain patients during a conflictual discussion, and to their attributions about patient pain behavior during a subsequent pain-induction task...
April 4, 2019: Journal of Pain: Official Journal of the American Pain Society
Whitney Scott, Lin Yu, Shrina Patel, Lance M McCracken
Chronic pain is a potentially stigmatizing condition. However, stigma has received limited empirical investigation in people with chronic pain. Therefore, we examined the psychometric properties of a self-report questionnaire of stigma in people with chronic pain attending interdisciplinary treatment. Secondarily, we undertook an exploratory examination of the magnitude of change in stigma associated with interdisciplinary treatment in a prospective observational cohort. Participants attending interdisciplinary treatment based on acceptance and commitment therapy completed the Stigma Scale for Chronic Illness 8-item version (SSCI-8; previously developed and validated in neurological samples), and measures of perceived injustice, pain acceptance, and standard pain outcomes before (n = 300) and after treatment (n = 247)...
March 30, 2019: Journal of Pain: Official Journal of the American Pain Society
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