Journal of Pain

Mari Glette, Tore C Stiles, Petter C Borchgrevink, Tormod Landmark
Epidemiological studies have to a little extent addressed the potential fluctuations of chronic pain over time, and there is a lack of information about the long-term course of pain using repeated measurements. We wanted to identify different trajectories of pain during eight waves of follow-up over four years among individuals in the general population reporting pain lasting at least six months at baseline. Secondarily, we wanted to investigate whether biopsychosocial factors at baseline were associated with the different pain trajectories...
November 4, 2019: Journal of Pain: Official Journal of the American Pain Society
Imke Courtois, Ali Gholamrezaei, Hassan Jafari, Stefan Lautenbacher, Ilse Van Diest, Lukas Van Oudenhove, Johan W S Vlaeyen
The aim of the study reported in this paper is to investigate the effect of slow-deep breathing (SDB) on self-reported pain, heart rate variability (HRV) and baroreflex sensitivity (BRS). These effects are examined in three separate experiments, each using a different phasic pain modality. For each experiment, different subjects were recruited. Eighty-three healthy female participants were instructed to breathe guided by a visual cue at a slow frequency (SDB: 0.1 Hz), and at a frequency close to the spontaneous breathing frequency (NPB: Normal Paced Breathing, 0...
November 4, 2019: Journal of Pain: Official Journal of the American Pain Society
Larissa Cordier, Xaver Fuchs, Stephan Herpertz, Jörg Trojan, Martin Diers
In this study, we investigated whether illusionary body ownership over artificial hands and non-corporeal objects modulates pain perception. Previous research has yielded to mixed results, but has separated painful stimulation used to test pain perception from the stimulation that was used to induce the illusion. Here, we used a variant of the rubber hand illusion (RHI) paradigm and induced the illusion directly via a combination of visual and painful stimuli. We presented heat pain stimuli at the real hand and visual stimuli beneath a rubber hand (part1), or a glass ball (part2)...
November 4, 2019: Journal of Pain
Karen Kaczynski, Elizabeth Ely, Debra Gordon, Catherine Vincent, Kristi Waddell, Kimberly Wittmayer, Esther Bernhofer
Pediatric pain assessment in the hospital traditionally involves the patient's self-report of pain intensity using a numeric rating scale, which does not capture the complexity of the pain experience. No valid, comprehensive measure of pain in hospitalized youth exists. This study was designed to develop and conduct initial psychometric testing of the Pediatric American Pain Society Patient Outcomes Questionnaire (Pediatric APS-POQ), a comprehensive patient-reported measure of pain and pain outcomes in hospitalized youth...
November 1, 2019: Journal of Pain: Official Journal of the American Pain Society
Jamie L Rhudy, Natalie Hellman, Cassandra A Sturycz, Tyler A Toledo, Shreela Palit
This study examined whether a modified version of biofeedback (ie, Conditioned Biofeedback) that incorporated placebo analgesia-like manipulations could promote anti-nociception in healthy, pain-free participants. During Conditioned Biofeedback (n=28), sympathetic arousal level was displayed visually and participants were asked to reduce it while they received painful electric stimulations that were surreptitiously controlled by their arousal level. Thus, electric pain decreased as arousal decreased to associate successful arousal-reduction/relaxation with pain relief, and to promote expectations for future pain relief...
November 1, 2019: Journal of Pain
Manlin Yao, Yi Lei, Peng Li, Qian Ye, Yang Liu, Xiaoyun Li, Weiwei Peng
Many studies have demonstrated a link between experiences of physical pain and those of social rejection, both of which can trigger cognitive processes involved in detecting, orienting toward, or reacting to potentially threatening events. This study tested the hypothesis that healthy individuals who are more sensitive to physical pain are also more sensitive to social rejection. We recruited participants with high or low pain-sensitivity (HPS and LPS), as assessed by scores on a pain-sensitivity questionnaire and confirmed by experimental pain-sensitivity assessment...
November 1, 2019: Journal of Pain
Jeongwi An, Kyeong-Seok Wang, Youn-Hee Jung, Sungkun Cho
Patients with chronic pain demonstrate interpretational bias to pain and models of pain suggest interpretational bias affects subsequent pain experience. This study developed an interpretation bias modification for pain (IBM-P) and examined its efficacy. A total of 48 patients with chronic pain were recruited and randomly assigned to either the training group (n = 24) or the control group (n = 24). Interpretational bias, negative emotions, and attentional bias to pain-related stimuli were assessed before and after conducting IBM-P...
November 1, 2019: Journal of Pain
Kevin E Vowles, Melissa Pielech, Karlyn A Edwards, Mindy L McEntee, Robert W Bailey
While much of the literature provides positive support for psychological interventions for chronic pain, two recent meta-analyses indicate small to moderate benefits only. This inconsistency in findings suggests that there are other treatment-related variables to consider. One possible consideration pertains to treatment format, as psychological models form the basis for both unidisciplinary psychology and integrated interdisciplinary treatments for chronic pain. Therefore, a comparative meta-analysis of unidisciplinary and interdisciplinary treatments was performed to determine whether there were differences in treatment effect size (ES) at post-treatment and follow-ups of up to one year...
November 1, 2019: Journal of Pain
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No abstract text is available yet for this article.
October 29, 2019: Journal of Pain
Caitlin Murray, Rocio de la Vega, Dorothy Loren, Tonya M Palermo
Cognitive-behavioral therapy (CBT) is effective for pediatric chronic pain, but little is understood about which youth are most likely to benefit. The current study aimed to identify individual characteristics for which CBT yielded the greatest (and least) clinical benefit among adolescents with chronic pain participating in a multi-center randomized controlled trial (RCT) of internet-delivered CBT (WebMAP2). A total of 273 adolescents ages 11-17 with chronic pain (Mage=14.7; 75.1% female) were randomly assigned to internet-delivered CBT or internet-delivered pain education and evaluated at pre-treatment, post-treatment, and two longer-term follow-up periods (6 and 12 months)...
October 10, 2019: Journal of Pain: Official Journal of the American Pain Society
Marco Lisicki, Kevin D'Ostilio, Gianluca Coppola, Romain Nonis, Alain Maertens de Noordhout, Vincenzo Parisi, Delphine Magis, Jean Schoenen
Migraine is characterized by an increased sensitivity to visual stimuli that worsens during attacks. Recent evidence has shown that feedforward volleys carrying incoming visual information induce high frequency (gamma) oscillations in the visual cortex, while feedback volleys arriving from higher order brain areas induce oscillatory activity at lower frequencies (theta/alpha/low-beta). We investigated visually induced high (feedforward) and low (feedback) frequency activations in healthy subjects and various migraine patients...
October 3, 2019: Journal of Pain: Official Journal of the American Pain Society
Shannon M Smith, Maurizio Fava, Mark P Jensen, Omar B Mbowe, Michael P McDermott, Dennis C Turk, Robert H Dworkin
Recent research has suggested that the magnitudes of analgesic treatment effects estimated in clinical trials have decreased over time. Implications of these findings for future sample size calculations and clinical trial research designs have not been addressed. In this article, we examine the standardized effect size (SES) for average pain intensity (API) and worst pain intensity (WPI) outcomes from randomized clinical trials (RCTs) of analgesic treatments shown to be efficacious for chronic low back pain, fibromyalgia, osteoarthritis pain, painful diabetic peripheral neuropathy, and postherpetic neuralgia that were published between 1980 and 2016...
September 30, 2019: Journal of Pain: Official Journal of the American Pain Society
Jason Hackett, Keith E Naugle, Kelly M Naugle
The purpose of this article was to examine age-related changes in conditioned pain modulation (CPM) and temporal summation of pain (TS) using meta-analytic techniques. Five electronic databases were searched for studies that compared measures of CPM and TS between healthy, chronic pain-free younger, middle-aged, and older adults. Eleven studies were included in the final review for TS and 11 studies were included in the review of CPM. The results suggested a moderate magnitude of difference in TS between younger adults and middle-aged/older adults, with the older cohorts exhibiting enhanced TS of pain...
September 25, 2019: Journal of Pain: Official Journal of the American Pain Society
Pedro Alvarez, Oliver Bogen, Jon D Levine
Occupational exposure to mechanical vibration can produce the Hand-Arm Vibration Syndrome (HAVS), whose most disabling symptom is persistent muscle pain. Unfortunately, the pathophysiology of HAVS pain is still poorly understood, precluding the development of mechanism-based therapies. Since interleukin 33 (IL-33) is essential for inflammation and recovery that follows skeletal muscle injury, we explored its role in muscle pain in a model of HAVS, in adult male rats. Concomitant to mechanical hyperalgesia, an increase in IL-33 in the ipsilateral gastrocnemius muscle was observed 24 h after vibration...
September 25, 2019: Journal of Pain: Official Journal of the American Pain Society
Maisa S Ziadni, John A Sturgeon, Daniel Bissell, Adam Guck, Kelly J Martin, Whitney Scott, Zina Trost
Despite growing evidence of significant racial disparities in the experience and treatment of chronic pain, the mechanisms by which these disparities manifest have remained relatively understudied. The current study examined the relationship between past experiences of racial discrimination and pain-related outcomes (self-rated disability and depressive symptomatology), and tested the potential mediating roles of pain catastrophizing and perceived injustice related to pain. Analyses consisted of cross-sectional path modeling in a multiracial sample of 137 individuals with chronic low back pain (Hispanics N=43; Blacks N=43; Whites N=51)...
September 25, 2019: Journal of Pain
Kevin F Boehnke, J Ryan Scott, Evangelos Litinas, Suzanne Sisley, David A Williams, Daniel J Clauw
Cannabis is widely used for chronic pain. However, there is some evidence of an inverse dose-response relationship between cannabis effects and pain relief which may negatively affect analgesic outcomes. In this cross-sectional survey, we examined whether daily cannabis use frequency was associated with pain severity and interference, quality of life measures relevant to pain (e.g., anxiety and depressive symptoms), and cannabis use preferences (administration routes, cannabinoid ratio). Our analysis included 989 adults who used cannabis every day for chronic pain...
September 24, 2019: Journal of Pain: Official Journal of the American Pain Society
Katie A Butera, Steven Z George, Trevor A Lentz
Psychological characteristics consistently predict clinical outcomes for musculoskeletal pain conditions. The Optimal Screening for Prediction of Referral and Outcome Yellow Flag (OSPRO-YF) tool assesses negative mood, fear-avoidance, and positive affect/coping. Psychometric testing of the tool is needed to guide clinical use. The purpose of this secondary analysis was to determine the OSPRO-YF factor structure (17- and 10-item versions) and test factor reliability and concurrent validity. Data from two musculoskeletal pain cohorts (n1=428; n2=440) were used...
September 18, 2019: Journal of Pain: Official Journal of the American Pain Society
Christine M van Vliet, Ann Meulders, Linda M G Vancleef, Elke Meyers, Johan W S Vlaeyen
Avoidance is considered key in the development of chronic pain. However, little is known about how avoidance behaviour subsequently affects pain-related fear and pain. We investigated this using a robotic arm reaching avoidance task to investigate this. In a between-subjects design both Experimental Group (n=30) and Yoked Control Group (n=30) participants perform either of three movement trajectories (T1-T3) to reach a target location. During acquisition, only participants of the Experimental Group could partially or fully avoid a painful electrocutaneous stimulus by choosing the intermediate trajectory (T2; 50% reinforcement) or the longest trajectory (T3; 0% reinforcement) versus the shortest trajectory (T1: 100% reinforcement)...
September 18, 2019: Journal of Pain
Chung Jung Mun, Mary C Davis, Claudia Campbell, Patrick Finan, Howard Tennen
Non-restorative sleep is a key diagnostic feature of the musculoskeletal pain disorder fibromyalgia, and is robustly associated with poor physical functioning, including activity interference. However, the mechanisms through which non-restorative sleep elicits activity interference among individuals with fibromyalgia at the within-person level remain unclear. The present study tested the following three-path mediation model, using data gathered from a 21-day electronic daily diary in 220 individuals with fibromyalgia: previous night non-restorative sleep → morning pain catastrophizing → afternoon pain severity → end-of-day activity interference...
September 14, 2019: Journal of Pain: Official Journal of the American Pain Society
Zilong Wang, Biao Xu, Changyu Jiang, Ting Zhang, Mengna Zhang, Ning Li, Qinqin Zhang, Kangtai Xu, Dan Chen, Jian Xiao, Quan Fang
The development of multitarget opioid drugs has emerged as an attractive therapeutic strategy to eliminate opioid-related side effects. Our previous study developed a series of opioid and neuropeptide FF (NPFF) pharmacophore-containing chimeric peptides, including DN-9 (Tyr-D.Ala-Gly-NMe.Phe-Gly-Pro-Gln-Arg-Phe-NH2 ), which produced potent nontolerance forming analgesia at the supraspinal level. In the present study, the antinociceptive effects of DN-9 in a series of preclinical pain models and the potential side-effects were investigated at the spinal level in mice...
September 12, 2019: Journal of Pain: Official Journal of the American Pain Society
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