Journal of Pain

Matthew R Sapio, Michael J Iadarola, Amelia J Loydpierson, Jenny J Kim, Danielle Thierry-Mieg, Jean Thierry-Mieg, Dragan Maric, Andrew J Mannes
Understanding molecular alterations associated with peripheral inflammation is a critical factor in selectively controlling acute and persistent pain. The present report employs in situ hybridization of the two opioid precursor mRNAs coupled with quantitative measurements of two peptides derived from the prodynorphin and proenkephalin precursor proteins: dynorphin A 1-8 and [Met5 ]-enkephalin-Arg6 -Gly7 -Leu8 (MERGL). In dorsal spinal cord ipsilateral to the inflammation, dynorphin A 1-8 was elevated after inflammation, and persisted as long as the inflammation was sustained...
January 10, 2020: Journal of Pain: Official Journal of the American Pain Society
Lingli Liang, Shaogen Wu, Corinna Lin, Yun-Juan Chang, Yuan-Xiang Tao
NrCAM, a neuronal cell adhesion molecule in the L1 family of the immunoglobulin superfamily, is subjected to extensively alternative splicing and is involved in neural development and some disorders. The aim of this study was to explore the role of Nrcam mRNA alternative splicing in neuropathic pain. A next generation RNA sequencing analysis of dorsal root ganglions (DRGs) showed the differential expression of two splicing variants of Nrcam, Nrcam+10 and Nrcam-10 , in the injured DRG after the fourth lumbar spinal nerve ligation (SNL)...
January 6, 2020: Journal of Pain: Official Journal of the American Pain Society
Simona Maccora, Nadia Bolognini, Giuseppe Cosentino, Roberta Baschi, Giuseppe Vallar, Brigida Fierro, Filippo Brighina
Multisensory processing can be assessed by measuring susceptibility to crossmodal illusions such as the Sound-Induced Flash Illusion (SIFI). When a single flash is accompanied by two or more beeps, it is perceived as multiple flashes (fission illusion); conversely, a fusion illusion is experienced when more flashes are matched with a single beep, leading to the perception of a single flash. Such illusory perceptions are associated to crossmodal changes in visual cortical excitability. Indeed, increasing occipital cortical excitability, by means of transcranial electrical currents, disrupts the SIFI (i...
January 3, 2020: Journal of Pain
Yuval Argaman, Lee B Kisler, Yelena Granovsky, Robert C Coghill, Elliot Sprecher, David Manor, Irit Weissman-Fogel
Altered pain modulation and resting state functional connectivity (rsFC) were found to be related to migraine pathology and clinical manifestation. We examined how pain modulation psychophysical measures are related to resting-state networks (RSNs) and rsFC between bottom-up and top-down pain modulation areas. Thirty-two episodic migraineurs and 23 age-matched healthy individuals underwent temporal summation of pain (TSOP) and conditioned pain modulation (CPM) tests, followed by a resting-state imaging scan...
January 2, 2020: Journal of Pain: Official Journal of the American Pain Society
Joshua R Zadro, Tom Ivar Lund Nilsen, Debra Shirley, Anita B Amorim, Paulo H Ferreira, Ragnhild Lier, Paul Jarle Mork
We investigated if parental multi-site chronic pain increases the risk of adult offspring developing additional chronic pain sites, and if offspring body mass index (BMI) and leisure time physical activity modify this association. We used longitudinal data on 7,654 offspring linked with their parents who participated in the population-based HUNT Study (Norway) in 1995-97 and 2006-08. Logistic regression was used to estimate odds ratios (ORs) with 95% confidence interval (CI). One-third of offspring (n=2,573) developed additional chronic pain sites...
January 2, 2020: Journal of Pain
Alexandria Brunkow, Margeaux Cannon, Fiona S Graff, Jessica L Martin, Leslie R M Hausmann, Lisa M McAndrew
The opioid crisis has highlighted the importance of improving patients' access to behavioral treatments for chronic pain and addiction. What is not known is if patients are interested in receiving these treatments. In this cross-sectional study, over 1000 participants with chronic pain were surveyed using an anonymous online questionnaire on Amazon Mechanical Turk (Mturk) to investigate participants' use of and interest in pharmacological and behavioral treatments for chronic pain and addiction. Participants also indicated whether their doctor had recommended these treatments...
January 2, 2020: Journal of Pain
Corey B Simon, Carolina Valencia, Rogelio A Coronado, Samuel S Wu, Zhigang Li, Yunfeng Dai, Kevin W Farmer, Michael M Moser, Thomas W Wright, Roger B Fillingim, Steven Z George
Shoulder surgery is a primary intervention for shoulder pain, yet many individuals experience persistent post-operative pain. Previously, we found individuals categorized as having a high-risk phenotype (comprised of COMT variation and pain catastrophizing) had approximately double the chance of not reaching a 12-month pain recovery criterion. As a means to better understand the development of persistent post-operative shoulder pain, this study advanced our previous work by examining temporal ordering of post-operative shoulder recovery based on potential mediating factors, and expansion of outcomes to include movement-evoked pain and shoulder active range of motion...
December 28, 2019: Journal of Pain: Official Journal of the American Pain Society
Rachel A Elphinston, Simone Scotti Requena, Daniel Angus, Dominique de Andrade, Christopher R Freeman, Melissa A Day
Codeine is one of the most common opioid medicines for treating pain. Australia introduced policy changes in February 2018 to up-schedule codeine to prescription-only medicine due to concerns of adverse effects, opioid dependency and overdose-related mortality. This study investigated the frequency and content of messages promoted on Twitter by four Australian peak pain organizations, pre- and post-policy implementation. A time series analysis examined frequency of Twitter posts over a 48-week period. Text analysis via Leximancer examined message content...
December 16, 2019: Journal of Pain
Jennifer S Gewandter, Robert H Dworkin, Dennis C Turk, Eric G Devine, David Hewitt, Mark P Jensen, Nathaniel P Katz, Amy A Kirkwood, Richard Malamut, John D Markman, Bernard Vrijens, Laurie Burke, James N Campbell, Daniel B Carr, Philip G Conaghan, Penney Cowan, Mittie K Doyle, Robert R Edwards, Scott R Evans, John T Farrar, Roy Freeman, Ian Gilron, Dean Juge, Robert D Kerns, Ernest A Kopecky, Michael P McDermott, Gwendolyn Niebler, Kushang V Patel, Richard Rauck, Andrew S C Rice, Michael Rowbotham, Nelson E Sessler, Lee S Simon, Neil Singla, Vladimir Skljarevski, Tina Tockarshewsky, Geertrui F Vanhove, Ajay D Wasan, James Witter
The estimated probability of progressing from phase 3 analgesic clinical trials to regulatory approval is approximately 57%, suggesting that a considerable number of treatments with phase 2 trial results deemed sufficiently successful to progress to phase 3 do not yield positive phase 3 results. Deficiencies in the quality of clinical trial conduct could account for some of this failure. An Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) meeting was convened to identify potential areas for improvement in trial conduct in order to improve assay sensitivity (i...
December 13, 2019: Journal of Pain: Official Journal of the American Pain Society
Debbie Ehrmann Feldman, Lisa C Carlesso, Richard L Nahin
The purpose of the study was to explore clinical management for new cases of musculoskeletal pain that are likely chronic. We used data from the National Ambulatory Medical Care Survey, 2007-2015, identifying visits with a new chronic musculoskeletal pain condition using pre-determined ICD-9 codes. We documented prescribing of non-opioid pain medication, opioids, physical therapy (PT), counseling, and other nonpharmacologic treatments and explored associations between patient and provider factors for each of these treatments...
December 11, 2019: Journal of Pain: Official Journal of the American Pain Society
Andrea Polli, Lode Godderis, Manosij Ghosh, Kelly Ickmans, Jo Nijs
Accumulating evidence suggests that epigenetic mechanisms may hold great potential in the field of pain. We systematically reviewed the literature exploring epigenetic mechanisms in people with pain. Four databases have been interrogated: MEDLINE, The Cochrane Central Register of Controlled Trial, Scopus, and Web of Science, following PRISMA guidelines in conducting study selection and assessment. Thirty-seven studies were included. Studies explored epigenetics in conditions such as fibromyalgia, CRPS, neuropathies, or osteoarthritis...
December 11, 2019: Journal of Pain: Official Journal of the American Pain Society
Ajay D Wasan, Benedict J Alter, Robert R Edwards, Charles E Argoff, Nalini Sehgal, David Walk, Toby Moeller-Bertram, Mark S Wallace, Misha Backonja
In health and disease, the somatosensory system has been interrogated with standardized research techniques, collectively referred to as quantitative sensory testing (QST). In neuropathic pain, QST has been used to characterize multiple sensory derangements. However, the use of QST outside the lab has been limited by several factors, including a lack of standardization, variability in procedural technique, and duration of testing that would be unacceptable for clinic. To address these shortcomings, the Neuropathic Pain Research Consortium (NPRC) designed an easy and low-cost "bedside" QST procedure...
December 11, 2019: Journal of Pain
Ryan A Mischel, Karan H Muchhala, William L Dewey, Hamid I Akbarali
It is increasingly recognized that chronic opioid use leads to maladaptive changes in the composition and localization of gut bacteria. Recently, this "opioid-induced dysbiosis" (OID) has been linked to antinociceptive tolerance development in preclinical models and may therefore identify promising targets for new opioid-sparing strategies. Such developments are critical to curb dose escalations in the clinical setting and combat the ongoing opioid epidemic. In this article, we review the existing literature that pertains to OID, including the current evidence regarding its qualitative nature, influence on antinociceptive tolerance, and future prospects...
December 10, 2019: Journal of Pain: Official Journal of the American Pain Society
Herick Ulisses de Oliveira, Rafaela Silva Dos Santos, Iago Henrique Silva Malta, José Phellipe Pinho, Ana Flávia Santos Almeida, Carlos Arterio Sorgi, Ana Paula Ferranti Peti, Gabriela Santos Xavier, Luciana Maria Dos Reis, Lúcia Helena Faccioli, Jader Dos Santos Cruz, Enio Ferreira, Giovane Galdino
Transcutaneous electrical nerve stimulation (TENS) promotes antinociception by activating the descending pain modulation pathway and consequently releasing endogenous analgesic substances. In addition, recent studies have shown that the endocannabinoid system controls pain. Thus, the present study investigated the involvement of the endocannabinoid system in TENS-induced antinociception of cancer pain using a cancer pain model induced by intraplantar ( injections of Ehrlich tumor cells in male Swiss mice...
November 27, 2019: Journal of Pain: Official Journal of the American Pain Society
Su Liu, Stephen Karaganis, Ru-Fan Mo, Xiao-Xiao Li, Ruo-Xin Wen, Xue-Jun Song
Neuropathic pain is difficult to treat and remains a major clinical challenge worldwide. While the mechanisms which underlie the development of neuropathic pain are incompletely understood, interferon signaling by the immune system is known to play a role. Here, we demonstrate a role for IFNβ in attenuating mechanical allodynia induced by the spared nerve injury in mice. The results show that intrathecal administration of IFNβ (dosages up to 5000U) produces significant, transient, and dose-dependent attenuation of mechanical allodynia without observable effects on motor activity or feeding behavior, as is common with IFN administration...
November 27, 2019: Journal of Pain: Official Journal of the American Pain Society
Guangyou Duan, Zhuoxi Wu, Zhenxin Duan, Guiying Yang, Liang Fang, Fang Chen, Xiaohang Bao, Hong Li
Spicy-food intake has been shown to affect various human physiological systems and diseases. This study tested the analgesia effect caused by stimulation of a spicy sensation (spicy stimulation) and explored the effect of spicy-food consumption on human basal pain sensitivity. A total of 60 healthy undergraduates were included in the primary study. Placebo and sweet stimulation were used as reference interventions. Pressure and cold-pain thresholds were measured before and after taste stimulation. The frequency of spicy-food intake was also evaluated...
November 26, 2019: Journal of Pain: Official Journal of the American Pain Society
Xi Luo, Jianzhao Liu, Xianwei Che
Previous studies have indicated a positive relationship between self-compassion and psychological and emotional well-being in chronic pain populations. However, evidence on the role and mechanisms of self-compassion in pain perception is largely limited. The current study was designed to investigate the effects and a potential mechanism of self-compassion on experimental pain. Thirty healthy participants underwent a compassionate self-talk protocol, which was followed by cold pain exposure during which high-frequency heart rate variability (HF-HRV) was evaluated...
November 21, 2019: Journal of Pain: Official Journal of the American Pain Society
Kevin E Vowles, Katie Witkiewitz, Karen J Cusack, Wesley P Gilliam, Karen E Cardon, Sarah Bowen, Karlyn A Edwards, Mindy L McEntee, Robert W Bailey
Opioid prescription in the treatment of chronic pain is frequent and carries a risk of increased morbidity and mortality in a clinically significant number of patients, particularly those who are using opioids in a hazardous manner. Few treatment options are available that target both pain-related interference and hazardous opioid use among patients with chronic pain. In military Veterans, this issue is of particular importance as numerous reports indicate continued high rates of opioid prescription for chronic pain, as well as significant opioid-related problems...
November 21, 2019: Journal of Pain
Chung Jung Mun, Janelle Letzen, Sabrina Nance, Michael T Smith, Harpal S Khanuja, Robert S Sterling, Mark C Bicket, Jennifer A Haythornthwaite, Robert N Jamison, Robert R Edwards, Claudia M Campbell
Epidemiological studies suggest that women are not only at a higher risk for developing knee osteoarthritis (KOA), but also report greater symptom severity compared to men. One potential underlying mechanism of these sex differences may be exaggerated inflammatory responses to pain among women compared to men. The present study examined sex differences in interleukin-6 (IL-6) response over time following experimental pain testing. We hypothesized that women, when compared to men, would show greater IL-6 reactivity when exposed to acute pain in a human laboratory setting...
November 13, 2019: Journal of Pain: Official Journal of the American Pain Society
Robert E Molokie, Zaijie J Wang, Yingwei Yao, Keesha L Powell-Roach, Judith M Schlaeger, Marie L Suarez, David A Shuey, Veronica Angulo, Jesus Carrasco, Miriam O Ezenwa, Roger B Fillingim, Diana J Wilkie
Evidence supports, but is inconclusive that sensitization contributes to chronic pain in some adults with sickle cell disease (SCD). We determined the prevalence of pain sensitization among adults with SCD pain compared with pain-free healthy adults. In a cross sectional, single session study of 186 African American outpatients with SCD pain (age 18-74 years, 59% female) and 124 healthy age, gender, and race matched control subjects (age 18-69 years, 49% female), we compared responses to standard thermal (Medoc TSA II) and mechanical stimuli (von Frey filaments)...
November 13, 2019: Journal of Pain: Official Journal of the American Pain Society
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