Suryakumar Narayanasamy, Fang Gang, Lili Ding, Kristie Geisler, Susan Glynn, Arjunan Ganesh, Madhankumar Sathyamoorthy, Victor Garcia, Peter Sturm, Vidya Chidambaran
Reliable, clinic-friendly screening for Chronic postsurgical pain (CPSP) risk is unavailable. Within a prospective, observational study, we evaluated Pediatric Pain Screening Tool (PPST), a concise 9-item questionnaire, as a preoperative screening tool to identify those at higher risk for CPSP (NRS>3/10 beyond three months post-surgery) and poor function (disability/FDI/quality of life/PedsQL)) after spine fusion and Nuss procedures. Incidence of CPSP was 34.86% (38/109). We confirmed PPST scale stability, test re-test reliability (ICC=0...
July 16, 2021: Journal of Pain
Jemma Todd, Daniel Rudaizky, Patrick Clarke, Louise Sharpe
The aim of the present study was to investigate the role of cognitive processing biases in Type 2 diabetes (T2D) and chronic pain, two conditions that are highly co-morbid. The final sample comprised 333 individuals (86 with T2D and chronic pain, 65 with chronic pain, 76 with T2D, 106 without any form of diabetes or pain). Participants completed questionnaires assessing pain and diabetes-related outcomes, as well as measures of interpretation bias, attentional bias, and attentional bias variability. In a 2 (pain status) x 2 (T2D status) x 3 (bias valence) ANOVA design, interpretation biases were found to be stronger in individuals with chronic pain than individuals without pain, although there were no differences according to T2D status...
July 16, 2021: Journal of Pain
Monika Patel, Alisa J Johnson, Staja Q Booker, Emily J Bartley, Shreela Palit, Keesha Powell-Roach, Ellen L Terry, Dottington Fullwood, Lucas DeMonte, Angela M Mickle, Kimberly T Sibille
Disparities in the experience of chronic musculoskeletal pain in the United States stem from a confluence of a broad array of factors. Organized within the National Institute on Aging Health Disparity Research Framework, a literature review was completed to evaluate what is known and what is needed to move chronic musculoskeletal pain research specific to disproportionately affected populations forward. Peer-reviewed studies published in English, on human adults, from 2000-2019, and conducted in the United States were extracted from PubMed and Web of Science...
July 16, 2021: Journal of Pain
Amy L Holley, Wendy Gaultney, Hayley Turner, Anna C Wilson
This cross-sectional study examines the utility of the Pediatric Pain Screening Tool (PPST) for rapidly assessing pain and psychosocial symptomatology in treatment-seeking youth with acute musculoskeletal pain. Participants were 166 youth (10-18 years, 53.6% female) participating in one of two larger cohort studies of youth with acute musculoskeletal pain. Youth completed the PPST and measures of pain, pain-related fear, pain catastrophizing, pain-related disability, and sleep quality. Participants were categorized into PPST risk groups using published cut-offs...
July 10, 2021: Journal of Pain
Jagjit Mankelow, Cormac Ryan, Paul Taylor, Greg Atkinson, Denis Martin
Pain is a significant health burden globally and its management frequently fails to comply with evidence based, biopsychosocial guidelines. This may be partly attributable to inadequate biopsychosocial focussed pain education for students and clinicians. We aimed to undertake a systematic review, using Cochrane methodology, of randomised controlled trials (RCTs) with meta-analysis to quantify the effects of biopsychosocial education strategies in changing student/qualified health care professionals (HCPs) pain related attitudes, knowledge, clinical behaviour or patient outcomes...
July 5, 2021: Journal of Pain
Dina Lelic, Anne Estrup Olesen, Debbie Grønlund, Fabricio Ariel Jure, Asbjørn Mohr Drewes
Moderate to severe pain is often treated with opioids, but central mechanisms underlying opioid analgesia are poorly understood. Findings thus far have been contradictory and none could infer opioid specific effects. This placebo-controlled, randomized, two-way cross-over, double-blinded study aimed to explore opioid specific effects on central processing of external stimuli. Twenty healthy male volunteers were included and three sets of assessments were done at each of the two visits: 1) baseline, 2) during continuous morphine or placebo intravenous infusion and 3) during simultaneous morphine + naloxone or placebo infusion...
July 3, 2021: Journal of Pain
Rashmi P Bhandari, Lauren E Harrison, Patricia A Richardson, Ana B Goya Arce, Dokyoung S You, Adithi Rajagopalan, Kathryn A Birnie, Soumitri Sil
Patient Reported Outcomes (PROs) are utilized in clinical registries and trials, necessitating development of benchmarks to enhance interpretability. This study aimed to 1) examine if PROMIS measures administered via computer adaptive testing (CAT) were responsive to change, and 2) highlight one method of assessing clinically significant change for youth seen in a tertiary pain clinic. Clinically significant change was achieved if patients had significantly reliable pre-to-post-changes greater than Reliable Change Index (RCI) value and reported decreased symptoms by at least one severity level (e...
July 3, 2021: Journal of Pain
Staja Q Booker, Emily J Bartley, Keesha Powell-Roach, Shreela Palit, Calia Morais, Osheeca J Thompson, Yenisel Cruz-Almeida, Roger B Fillingim
Racial equity is imperative to the future and integrity of scientific inquiry. In 2020, citizens of the United States (and globally) witnessed one of the most vile and egregious experiences of police brutality and systemic racism in recent history, the public execution of a Black American man. While some may isolate this and other similar events from influencing the scientific endeavors of pain researchers, events such as this can have a direct impact on the study, lived experience, and expression of pain in Black Americans...
June 30, 2021: Journal of Pain
Kevin F Boehnke, Joel J Gagnier, Lynne Matallana, David A Williams
Many people with fibromyalgia use cannabidiol (CBD) products despite limited rigorous evidence of benefit. In the current study, we conducted a secondary analysis of a cross-sectional survey of N=878 people with fibromyalgia to investigate naturalistic decision making around CBD product choices, use patterns, and dosing. We subgrouped participants based on use of high-THC cannabis (HTC) in the past year (yes/no) as previous studies have shown that HTC use influences CBD use patterns. The study population was largely female (93...
June 29, 2021: Journal of Pain
Corey J Hayes, Erin E Krebs, Joshua Brown, Chenghui Li, Teresa Hudson, Bradley C Martin
The purpose of this study was to evaluate changes in pain intensity among Veterans transitioning from long-term opioid therapy (LTOT) to either intermittent therapy or discontinuation compared to continued LTOT. Pain intensity was assessed using the Numeric Rating Scale in 90-day increments starting in the 90-day period prior to potential opioid transitions and the two ensuing 90-day periods after transition. Primary analyses used a 1:1 greedy propensity matched sample. A total of 29,293 Veterans switching to intermittent opioids and 5,972 discontinuing opioids were matched to Veterans continuing LTOT...
June 26, 2021: Journal of Pain
Enrico De Martino, Luisina Gregoret, Matteo Zandalasini, Thomas Graven-Nielsen
Peak alpha frequency (PAF) reduces during cutaneous pain, but no studies have investigated PAF during movement-related muscle pain. Whether high-pain sensitive (HPS) individuals exhibit a more pronounced PAF response to pain than low-pain sensitive (LPS) individuals is unclear. As a pain model, twenty-four participants received nerve growth factor injections into a wrist extensor muscle at Day0, Day2, and Day4. At Day4, a subgroup of twelve participants also undertook eccentric wrist exercise to induce additional pain...
June 25, 2021: Journal of Pain
Sun-Jeong Bae, Jeong-Yeon Ji, Ju-Young Oh, Jiyoon Won, Yeon-Hee Ryu, Hyangsook Lee, Hyuk-Sang Jung, Hi-Joon Park
While mast cells (MCs) are previously well-known as a pathological indicator of pain, their role in alleviating pain is recently emerged in acupuncture research. Thus, this study systematically reviews the role of MC in acupuncture analgesia. Animal studies on MC changes associated with the acupuncture analgesia were searched in PubMed and EMBASE. The MC number, degranulation ratio and pain threshold changes were collected as outcome measures for meta-analyses. Twenty studies were included with 13 suitable for meta-analysis, most with a moderate risk of bias...
June 25, 2021: Journal of Pain
Aimie L Peek, Andrew M Leaver, Sheryl Foster, Georg Oeltzschner, Nicolaas A Puts, Graham Galloway, Michele Sterling, Karl Ng, Kathryn Refshauge, Maria Eliza Aguila, Trudy Rebbeck
Treatment outcomes for migraine and other chronic headache and pain conditions typically demonstrate modest results. A greater understanding of underlying pain mechanisms may better inform treatments and improve outcomes. Increased GABA+ has been identified in recent studies of migraine, however, it is unclear if this is present in other headache and pain conditions. We primarily investigated GABA+ levels in the posterior cingulate gyrus (PCG) of people with migraine, whiplash-headache and low back pain compared to age- and sex-matched controls, GABA+ levels in the anterior cingulate cortex (ACC) and thalamus formed secondary aims...
June 25, 2021: Journal of Pain
Rui Li, Robert H Dworkin, Benjamin P Chapman, Adan Z Becerra, Luoying Yang, Christopher J Mooney, Christopher L Seplaki
Despite extensive research on the development and risk factors of chronic pain, the process of recovery from chronic pain in later life has been rarely studied. We estimated the recovery rate of moderate to severe chronic pain (chronic pain of moderate or severe severity or interfering with usual activities) among older adults and investigated predictors of recovery. Leveraging the longitudinal Health and Retirement Study 2006-2016 data (6 waves), we estimated the biennial national attrition-adjusted recovery rate of moderate to severe chronic pain among 6,132 US adults aged 65-75 at baseline...
June 23, 2021: Journal of Pain
Edmund Keogh, Nina Attridge, Joseph Walsh, Jessica Bartlett, Rachel Francis, Janet H Bultitude, Christopher Eccleston
This study investigated whether there are gender differences in attention to bodily expressions of pain and core emotions. Three experiments are reported using the attentional dot probe task. Images of men and women displaying bodily expressions, including pain, were presented. The task was used to determine whether participants' attention was drawn towards or away from target expressions. Inconsistent evidence was found for an attentional bias towards body expressions, including pain. While biases were affected by gender, patterns varied across the Experiments...
June 23, 2021: Journal of Pain
Divyan Chopra, Chenghui Li, Jacob T Painter, Jonathan P Bona, Intawat Nookaew, Bradley C Martin
Increasing emphasis on guidelines and prescription drug monitoring programs highlight the role of healthcare providers in pain treatment. Objectives of this study were to identify characteristics of key players and influence of opioid prescribers through construction of a referral network of patients with chronic pain. A retrospective cohort study was performed and patients with commercial or Medicaid coverage with chronic back, neck, or joint pain were identified using the Arkansas All-Payer Claims-Database...
June 23, 2021: Journal of Pain
Justyna Brączyk, Przemysław Bąbel
The aim of this study was to investigate the effect on observationally acquired placebo analgesia of a model's self-confidence as well as the observer's self-esteem and self-efficacy. In addition, we aimed to verify the stability of the placebo effect induced by observational learning. Participants (N = 60) were randomly assigned to one of three groups: a self-confident model, an unself-confident model, and a control group. In the experimental groups, participants watched a videotaped model who rated the intensity of electrocutaneous pain stimuli applied in the placebo condition as lower than those applied in the non-placebo condition...
June 21, 2021: Journal of Pain
Georgina Palomés-Borrajo, Jordi Badia, Xavier Navarro, Clara Penas
Neuropathic pain is a common disability produced by enhanced neuronal excitability after nervous system injury. The pathophysiological changes that underlie the generation and maintenance of neuropathic pain require modifications of transcriptional programs. In particular, there is an induction of pro-inflammatory neuromodulators levels, and changes in the expression of ion channels and other factors intervening in the determination of the membrane potential in neuronal cells. We have previously found that inhibition of the BET proteins epigenetic readers reduced neuroinflammation after spinal cord injury...
June 19, 2021: Journal of Pain
Laurent F Martin, Aubin Moutal, Kevin Cheng, Stephanie M Washington, Hugo Calligaro, Vasudha Goel, Tracy Kranz, Tally M Largent-Milnes, Rajesh Khanna, Amol Patwardhan, Mohab M Ibrahim
Benefits of phototherapy were characterized in multiple diseases including depression, circadian rhythm disruptions, and neurodegeneration. Studies on migraine and fibromyalgia patients revealed that green light-emitting diodes (GLED) exposure provides a pragmatic and safe therapy to manage chronic pain. In rodents, GLED reversed hypersensitivity related to neuropathic pain. However, little is known about the underlying mechanisms of GLED efficacy. Here, we sought to understand how green light modulates the endogenous opioid system...
June 19, 2021: Journal of Pain
Nicholas J Bush, Victor Schneider, Landrew Sevel, Mark D Bishop, Jeff Boissoneault
Musculoskeletal pain is an aversive experience that exists within a variety of conditions and can result in significant impairment for individuals. Gaining greater understanding of the factors related to pain vulnerability and resilience to musculoskeletal pain may help target at-risk individuals for early intervention. This analysis builds on our previous work identifying regions where greater gray matter density (GMD) was associated with lower pain following standardized, exercise induced musculoskeletal injury...
June 7, 2021: Journal of Pain
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