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Journal of Pain

Samsuk Kim, Daniel Whibley, David A Williams, Anna L Kratz
Daily fluctuation in pain acceptance and its impact on the physical and psychosocial functioning of individuals living with spinal cord injury (SCI) and chronic pain has not been examined. We used end-of-day (EOD) diaries and multilevel mixed effects modeling (MLM) to examine the moderating effect of within- and between-person pain acceptance on associations between pain and physical and psychosocial functioning. Individuals with SCI and chronic pain (N = 124) completed seven days of EOD diaries, which included measures of pain acceptance, pain intensity, pain catastrophizing, pain interference, participation in social roles and activities (SRA), depressive symptoms, and positive affect and well-being (PAWB)...
September 11, 2019: Journal of Pain
Daniel Machado, Ana Luiza Cabrera Martimbianco, Sandra Kalil Bussadori, Rafael Leite Pacheco, Rachel Riera, Elaine Marcílio Santos
This systematic review investigated the effectiveness and safety of botulinum toxin type A (BTX-A) for painful temporomandibular disorders. We searched for randomized controlled trials (RCTs) in ten databases, from inception to February 12, 2019 (MEDLINE, EMBASE, CENTRAL, LILACS, BBO, Web of Science, Scopus,, WHO and OpenGrey). We included 12 RCTs that compared BTX-A versus inactive or active interventions. BTX-A was slightly more effective than placebo for pain reduction at one month: mean difference (MD) -1...
September 9, 2019: Journal of Pain
Robert M Levy, Nagy Mekhail, Jeffrey Kramer, Lawrence Poree, Kasra Amirdelfan, Eric Grigsby, Peter Staats, Allen W Burton, Abram H Burgher, James Scowcroft, Stan Golovac, Leonardo Kapural, Richard Paicius, Jason Pope, Sam Samuel, W Porter McRoberts, Michael Schaufele, Alexander R Kent, Adil Raza, Timothy R Deer
The ACCURATE randomized, controlled trial compared outcomes of dorsal root ganglion (DRG) stimulation versus tonic spinal cord stimulation (SCS) in 152 subjects with chronic lower extremity pain due to complex regional pain syndrome (CRPS) type I or II. This ACCURATE sub-study was designed to evaluate whether therapy habituation occurs with DRG stimulation as compared to SCS through 12-months. A modified intention-to-treat analysis was performed to assess percentage pain relief (PPR) and responder rates at follow-up visits (end-of-trial, 1, 3, 6, 9, 12-months post-permanent implant) for all subjects that completed trial stimulation (DRG:N=73, SCS:N=72)...
September 5, 2019: Journal of Pain: Official Journal of the American Pain Society
Anna C Wilson, Amy L Holley, Amanda Stone, Jessica L Fales, Tonya M Palermo
This longitudinal case-control study aims to 1) compare symptoms and functioning in otherwise healthy adolescents with versus without a parent with chronic pain (Parent CP+/Parent CP-) 2) test adolescent sex as a moderator of the relation between parent CP group and child functioning, and 3) determine changes in adolescent pain over one year. Adolescents (n=140; ages 11-15) completed tests of pain responsivity and physical function, as well as self-report measures assessing pain characteristics, somatic symptoms, and physical and psychosocial functioning...
September 5, 2019: Journal of Pain: Official Journal of the American Pain Society
Aleksandrina Skvortsova, Dieuwke S Veldhuijzen, Henriët Van Middendorp, Luana Colloca, Andrea W M Evers
Oxytocin has been shown to increase trust, decrease anxiety and affect learning as has been observed in conditioning paradigms. Trust, anxiety and learning are important factors that influence placebo effects. In this study we investigated whether oxytocin can increase placebo analgesia, decrease nocebo hyperalgesia, and influence extinction processes of both. Eighty male volunteers were assigned to a 40 IU of oxytocin nasal spray group, or to a placebo control group. Placebo analgesia and nocebo hyperalgesia were induced by a conditioning procedure in combination with verbal suggestions...
September 5, 2019: Journal of Pain: Official Journal of the American Pain Society
Wen-Qiang Cui, Yu-Xia Chu, Fei Xu, Teng Chen, Lu Gao, Yi Feng, Xue-Ming Hu, Wei Yang, Li-Xia Du, Wen-Wen Zhang, Qi-Liang Mao-Ying, Wen-Li Mi, Yan-Qing Wang
Orofacial pain is characterized by its easy spread to adjacent areas, thus presenting with primary hyperalgesia (hypersensitivity at the site of injury) and secondary hyperalgesia (extra-territorial hypersensitivity outside the injured zone). However, the mechanisms behind the secondary hyperalgesia are poorly understood. In the present study, we used a mouse model of partial transection of the infraorbital nerve (pT-ION) to study whether calcium channel subunit α2δ1 (Cavα2δ1) and its downstream signaling contributes to the development of secondary hyperalgesia in the orofacial area...
September 5, 2019: Journal of Pain
Chuck Vierck
Mechanisms of below-level pain are discoverable as rostral neural adaptations to spinal injury. Accordingly, the strategy of investigations summarized here has been to characterize behavioral and neural responses to below-level stimulation over time following selective lesions of spinal gray and/or white matter. Assessments of human pain and the pain sensitivity of humans and laboratory animals following spinal injury have revealed common disruptions of pain processing. Interruption of the spinothalamic pathway partially deafferents nocireceptive cerebral neurons, rendering them spontaneously active and hypersensitive to remaining inputs...
September 4, 2019: Journal of Pain
Kristin L Schreiber, Inna Belfer, Christine Miaskowski, Mark Schumacher, Brett R Stacey, Thomas Van De Ven
Acute pain after breast surgery decreases the quality of life of cancer survivors. Previous studies using a variety of definitions and methods report prevalence rates between 10% to 80%, which suggests the need for a comprehensive framework that can be used to guide assessment of acute pain and pain-related outcomes after breast surgery. A multidisciplinary task force with clinical and research expertise performed a focused review and synthesis and applied the five dimensional framework of the AAAPT (Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION)- American Academy of Pain Medicine (AAPM)-American Pain Society (APS) Pain Taxonomy) to acute pain after breast surgery...
September 4, 2019: Journal of Pain
L Bijker, M L S Sleijser-Koehorst, M W Coppieters, P Cuijpers, G G M Scholten-Peeters
Depression, anxiety and somatization influence the recovery of people with musculoskeletal pain. A Delphi study was conducted to reach consensus on the most appropriate self-administered questionnaires to assess these psychosocial factors in people at risk of developing persistent musculoskeletal pain. A multidisciplinary panel of international experts was identified via PubReMiner. The experts (N=22) suggested 24 questionnaires in Round 1. In Round 2, experts rated the questionnaires on suitability, considering clinimetrics, content, feasibility, personal experiences and expertise...
September 2, 2019: Journal of Pain: Official Journal of the American Pain Society
Roland Staud, Melyssa M Godfrey, Marlin Mejia, Riddhi Ramanlal, Joseph L Riley, Michael E Robinson
Quantitative sensory testing (QST) is used to systematically interrogate normal responding and alterations of nervous system function, including pain related central sensitization (CS). However, up to now QST of CS in human subjects has been mostly focused on temporal summation of second pain (TSSP), has been difficult to perform, and has been associated with low reliability. In contrast, slow ramp & hold (RH) procedures are simpler tests of temporal summation and easier to perform. We examined the usefulness of RH procedures as reliable generators of CS using two validated QST procedures: decay of pain aftersensations and wind-down...
August 16, 2019: Journal of Pain: Official Journal of the American Pain Society
Emanuele Maria Giusti, Annelies Jonkman, Gian Mauro Manzoni, Gianluca Castelnuovo, Caroline B Terwee, Leo D Roorda, Alessandro Chiarotto
The Hospital Anxiety and Depression Scale (HADS) is a scale originally developed for the assessment of anxiety and depression in hospitalized patients. Despite its wide diffusion, the HADS factorial structure has displayed inconsistent results, leaving doubts about its use in chronic musculoskeletal pain. The purpose of this study was to thoroughly assess the factorial structure of the HADS in patients with chronic pain and to give guidance for a potential refinement. Data from 2522 patients with chronic pain from the Amsterdam Pain (AMS-PAIN) cohort were analyzed through: (1) exploratory bifactor analysis based on a Schmid-Leiman orthogonalization, (2) confirmatory factor analysis comparing a unidimensional model, the original correlated factors model and a bifactor model, (3) item response theory (IRT) analysis based on the graded response model...
August 14, 2019: Journal of Pain
Yael Lahav, Zahava Solomon, Alana Siegel, Noga Tsur, Ruth Defrin
Trauma survivors may suffer from posttraumatic stress disorder (PTSD), elevated posttraumatic guilt (PG), and alterations in the pain system. However, the association between PG and alterations in pain perception and modulation among trauma survivors has not been established, nor has the possible underlying role of PG. This longitudinal study investigated: 1) the unique contribution of PG in predicting pain perception and modulation, while controlling for PTSD symptoms; and 2) the mediating role of PG in explaining pain perception and modulation among torture survivors, above and beyond PTSD symptoms...
August 8, 2019: Journal of Pain: Official Journal of the American Pain Society
Sarah Nelson, Kristen Uhl, Laura A Wright, Deirdre Logan
Burn injuries are significantly painful and associated with physical and psychological impairment. However, little research to-date has examined the potential role of the subjective experience of pain in either physical or psychological impairment in this population. This may be particularly important to examine, given that the pain experience can often be a significant barrier to recovery in other pediatric populations. The current study examined the cross-sectional and predictive relationships between patient-reported experience of pain (operationalized as PROMIS pain interference and self-reported pain intensity) and physical and psychosocial outcomes...
August 8, 2019: Journal of Pain: Official Journal of the American Pain Society
Zhaoxia Qin, Xin-Wei He, Jilei Zhang, Shuai Xu, Ge-Fei Li, Jingjing Su, Yan-Hui Shi, Shiyu Ban, Yue Hu, Yi-Sheng Liu, Mei-Ting Zhuang, Rong Zhao, Xiao-Lei Shen, Jianqi Li, Jian-Ren Liu, Xiaoxia Du
The brainstem has been discussed as the main player in the pathogenesis of migraine. Dysfunctional brainstem nuclei and their abnormal connections to other key brain centers may contribute to headache and other symptoms of migraine. In the present study, 32 patients with migraine without aura (MWoA) and 32 age- and sex-matched healthy controls (HCs) underwent resting-state fMRI scans. We used masked independent analysis (mICA) to investigate whether patients with MWoA exhibited abnormal brainstem nuclei-cortical functional connectivity (FC)...
August 7, 2019: Journal of Pain: Official Journal of the American Pain Society
Adrienne L Adler-Neal, Christian E Waugh, Eric L Garland, Hossam A Shaltout, Debra I Diz, Fadel Zeidan
Mindfulness meditation is a self-regulatory practice premised on sustaining non-reactive awareness of arising sensory events that reliably reduces pain. Yet, the specific analgesic mechanisms supporting mindfulness have not been comprehensively disentangled from the potential non-specific factors supporting this technique. Increased parasympathetic nervous system (PNS) activity is associated with pain relief corresponding to a number of cognitive manipulations. However, the relationship between the PNS and mindfulness-based pain attenuation remains unknown...
August 1, 2019: Journal of Pain: Official Journal of the American Pain Society
Megan M Miller, Amy E Williams, Tamika C B Zapolski, Kevin L Rand, Adam T Hirsh
Previous studies have documented that racial minorities and women receive poorer pain care than their demographic counterparts. Providers contribute to these disparities when their pain-related decision-making systematically varies across patient groups. Less is known about racial and gender disparities in children with pain or the extent to which providers contribute to these disparities. In a sample of 129 medical students (henceforth referred to as 'providers'), Virtual Human methodology and a pain-related version of the Implicit Association Test (IAT) were used to examine the effects of patient race/gender on providers' pain assessment/treatment decisions for pediatric chronic abdominal pain, as well as the moderating role of provider implicit pain-related race/gender attitudes...
July 27, 2019: Journal of Pain: Official Journal of the American Pain Society
Aline P Brietzke, Maxciel Zortea, Fabiana Carvalho, Paulo R S Sanches, Jr Danton P Silva, Iraci Lucena da Silva Torres, Felipe Fregni, Wolnei Caumo
This randomized, double-blind controlled trial tested the hypothesis that sixty sessions of home-based anodal (a)-transcranial direct current stimulation (tDCS) over dorsolateral prefrontal cortex (DLPFC) would be better than home-based sham-tDCS to improve the widespread pain and the disability-related to pain (DRP). tDCS was self-administered with a specially developed device after in-person training. The anodal-tDCS (2mA for 30 mins) over the left DLPFC was self-administered with a specially developed device following in-person training...
July 26, 2019: Journal of Pain: Official Journal of the American Pain Society
Kai Karos, Ann Meulders, Liesbet Goubert, Johan W S Vlaeyen
Earlier research studying the effects of social threat on the experience and expression of pain led to mixed results. In this study, female participants (N = 32) came to the lab with two confederates. Both confederates administered a total of 10 painful electrocutaneous stimuli to the participant. The framing of the administration was manipulated in a within-subjects design: In the low social threat condition the participant was told that the confederate could choose between 10 to 20 pain stimuli, thus they believed that this confederate chose to administer the minimum allowed number of pain stimuli...
July 25, 2019: Journal of Pain: Official Journal of the American Pain Society
F Baert, M M Miller, Z Trost, A T Hirsh, J McParland, M De Schryver, T Vervoort
A growing pediatric and adult literature highlights the role of injustice appraisals in adjustment to pain. However, interpersonal injustice dynamics have remained largely unexplored. The present study investigated the factor structure and criterion validity of parentally-adjusted versions of the Injustice Experience Questionnaire, assessing child-oriented (IEQ-Pc) and self-oriented appraisals (IEQ-Ps) in the context of child pain. Participants were triads of healthy children (N=407, Mage =12) and both their parents and dyads of children with chronic pain (N=319, Mage =14) and one parent...
July 17, 2019: Journal of Pain: Official Journal of the American Pain Society
Hannah C Timmins, Tiffany Li, Matthew C Kiernan, Lisa G Horvath, David Goldstein, Susanna B Park
Chemotherapy-induced peripheral neuropathy (CIPN) is a major, dose-limiting side effect of treatment with neurotoxic cancer treatments which can result in long-term impairment. Deficits often reflect a large fiber polyneuropathy, however small fiber involvement resulting in neuropathic pain and autonomic dysfunction can occur. Quantification of both CIPN and small fiber neuropathy (SFN) remains a challenge. Accordingly, the prevalence and pathophysiology of small fiber neuropathy amongst cancer survivors remains poorly understood...
July 17, 2019: Journal of Pain: Official Journal of the American Pain Society
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