Arthur A Stone, Joan E Broderick, Roberta E Goldman, Doerte U Junghaenel, Alicia Bolton, Marcella May, Stefan Schneider
Pain assessment that fully represents patients' pain experiences is essential for chronic pain research and management. The traditional primary outcome measure has been a patient's average pain intensity over a time period. In this series of three articles, we examine whether pain assessment can be enhanced by considering additional outcome measures capturing temporal aspects of pain, such as pain maxima, duration, and variability. Ecological momentary assessment (EMA) makes the assessment of such indices readily available...
September 15, 2020: Journal of Pain
Jana Borovskis, Rocco Cavaleri, Felicity Blackstock, Simon J Summers
Exercise-induced hypoalgesia (EIH) describes acute reductions in pain that occur following exercise. Current evidence suggests that the magnitude of EIH is small-to-moderate at best, warranting exploration of novel avenues to bolster these effects. Transcranial direct current stimulation (tDCS) has been shown to relieve pain and represents a promising intervention that may enhance EIH. This study aimed to determine whether anodal tDCS of the primary motor cortex (M1) can augment EIH in healthy individuals experiencing experimentally-induced musculoskeletal pain...
September 11, 2020: Journal of Pain
Emily P Mills, Rahena Akhter, Flavia Di Pietro, Greg M Murray, Chris C Peck, Paul M Macey, Luke A Henderson
Evidence in preclinical models of chronic pain and human psychophysical investigations has suggested that alterations in endogenous brainstem pain-modulation circuit functioning are critical for the initiation and maintenance of pain. Whilst preclinical models have begun to explore the functioning of this circuitry in chronic pain, little is known about such functioning in humans with chronic pain. The aim of this investigation was to determine whether individuals with chronic non-neuropathic pain, painful Temporomandibular Disorders (TMD), display alterations in brainstem pain-modulating circuits...
September 4, 2020: Journal of Pain: Official Journal of the American Pain Society
Yael Lahav, David Levy, Avi Ohry, Gabi Zeilig, Meir Lahav, Hava Golander, Anat-Chacham Guber, Orit Uziel, Ruth Defrin
Chronic pain induces a multitude of harmful effects; recently it has been suggested that chronic pain is also associated with premature aging, manifested in shortened telomere length (TL). However, evidence for this hypothesis is scarce and inconsistent. The aim was twofold: 1) Investigate whether chronic pain is associated with premature aging, and 2) Determine whether physical exercise (PE) moderates this association if it exists. Participants were 116 male subjects, with (n=67) and without chronic pain (n=49)...
August 13, 2020: Journal of Pain: Official Journal of the American Pain Society
Shan Wang, Christopher Eccleston, Edmund Keogh
We are able to recognise others' experience of pain from their facial expressions. However, little is known about what makes the recognition of pain possible and whether it is similar or different from core emotions. This study investigated the mechanisms underpinning the recognition of pain expressions, in terms of spatial frequency (SF) information analysis, and compared pain with two core emotions (i.e. fear and happiness). Two experiments using a backward masking paradigm were conducted to examine the time course of low- and high-SF information processing, by manipulating the presentation duration of face stimuli and target-mask onset asynchrony...
August 6, 2020: Journal of Pain
Xue Tian, He Zhu, Shibin Du, Xue-Qing Zhang, Fuqing Lin, Fengtao Ji, Yung-Hao Tsou, Zhongyu Li, Yi Feng, Kathryn Ticehurst, Stephen Hannaford, Xiaoyang Xu, Yuan-Xiang Tao
The management of persistent postsurgical pain and neuropathic pain remains a challenge in the clinic. Local anesthetics have been widely used as simple and effective treatment for these two disorders, but the duration of their analgesic effect is short. We here reported a new poly lactic-co-glycolic acid (PLGA)-coated ropivacaine that was continuously released in vitro for at least 6 days. Peri-sciatic nerve injection of the PLGA-coated ropivacaine attenuated paw incision-induced mechanical allodynia and heat hyperalgesia during the incisional pain period, and spared nerve injury-induced mechanical and cold allodynia for at least 7 days post-injection...
July 30, 2020: Journal of Pain: Official Journal of the American Pain Society
Jacklynn M Fitzgerald, Emily L Belleau, Lauren E Ehret, Colleen Trevino, Karen J Brasel, Christine Larson, Terri deRoon-Cassini
There is significant heterogeneity in pain outcomes following motor vehicle crashes (MVCs), such that a sizeable portion of individuals develop symptoms of chronic pain months after injury while others recover. Despite variable outcomes, the pathogenesis of chronic pain is currently unclear. Previous neuroimaging work implicates the dorsal anterior cingulate cortex (dACC) in adaptive control of pain, while prior resting state functional magnetic resonance imaging studies find increased functional connectivity (FC) between the dACC and regions involved in pain processing in those with chronic pain...
July 28, 2020: Journal of Pain: Official Journal of the American Pain Society
Rita Canaipa, Diogo Mendonça, Mariana Agostinho, Vanda Nascimento, Liat Honigman, Roi Treister
The subjective nature of pain and the lack of a gold standard for objective measurement hinders effective assessment, diagnosis, and treatment. Some individuals, such as professional dancers, are better in assessing and reporting bodily sensations. This observational study aimed to assess whether dancers report their pain less variably, than other people do. After consenting, subjects completed the Focused Analgesia Selection Task (FAST), which assesses subjects' variability of pain reports. FAST outcomes, ICC and R2 reflect the magnitude of variability of pain reports observed...
July 20, 2020: Journal of Pain: Official Journal of the American Pain Society
Vasilis S Vasiliou, Evangelos C Karademas, Yiolanda Christou, Savvas Papacostas, Maria Karekla
Prevention of headaches via avoidance of triggers remains the main behavioral treatment suggestion for headache management despite trigger avoidance resulting in increases in potency, lifestyle restrictions, internal locus of control decreases, pain exacerbation and maintenance. New approaches, such as Acceptance and Commitment Therapy (ACT), instead emphasize acceptance and valued living as alternatives to avoidance. Though ACT is an empirically supported treatment for chronic pain, there is limited evidence for headache management whilst preliminary outcome studies are afflicted with methodological limitations...
July 16, 2020: Journal of Pain
Lydia Lo, Georgine Lamvu, Meryl Alappattu, Kathryn Witzeman, Daniela Markovic, Andrea Rapkin
Diagnostic criteria for provoked vestibulodynia (PVD) rely on mucosal pain in the vulvar vestibule, with less emphasis on pain from pelvic floor muscles. It is unknown how psychosocial variables associated with PVD are differentially associated with mucosal versus muscle pain. Analysis of data from the National Vulvodynia Registry (n=202) revealed several factors associated with increased mucosal pain: pain duration (p=0.043), the McGill sensory subscore (p=0.0086) and the Gracely pain scale (p<0.001). Increased mucosal pain was also associated with decreased arousal (p=0...
July 14, 2020: Journal of Pain: Official Journal of the American Pain Society
Dolors Soler, David Moriña, Hatice Kumru, Joan Vidal, Xavier Navarro
Treatment of neuropathic pain (NP) in patients with spinal cord injury (SCI) remains a major challenge. The aim of the present study is to investigate if the effect of transcranial direct current stimulation (tDCS) combined with visual illusion (VI), following a previously published protocol, has differential effects on pain-related sensory symptoms according to sensory phenotypes profiles. One hundred and thirty SCI patients with NP participated in this open-label trial. Sixty-five patients were given a daily 20-minutes combined treatment of tDCS and VI for 2 weeks...
July 3, 2020: Journal of Pain: Official Journal of the American Pain Society
Andrea K Newman, Calia A Morais, Benjamin P Van Dyke, Beverly E Thorn
The examination of pain beliefs for chronic pain assessment and treatment has been a growing area of interest. A variety of questionnaires have been developed to assess pain beliefs, however, these questionnaires often require high levels of literacy and education. The pain concepts questionnaire (PCQ) was developed with literacy-adaptations to better evaluate pain beliefs in a low socioeconomic (SES) population. This study is an initial exploratory evaluation of the PCQ in a sample of patients with chronic pain and multiple disparities as part of the learning about my pain (LAMP) trial, a randomized controlled trial comparing literacy-adapted psychosocial treatments for chronic pain...
June 27, 2020: Journal of Pain: Official Journal of the American Pain Society
Claire Thornton, David Sheffield, Andrew Baird
During pain, motor performance tends to decline. However, athletes who engage in contact sports are able to maintain performance despite the inherent pain that accompanies participation. This may be the result of being challenged rather than threatened by pain; adaptive coping strategies; habituation to pain; or finding pain less bothersome. This study aimed to measure performance of a novel motor task both in pain and not in pain within experienced contact athletes (n = 40), novice contact athletes (n = 40), and noncontact athletes (n = 40)...
June 26, 2020: Journal of Pain: Official Journal of the American Pain Society
Yurun Cai, Suzanne G Leveille, Jeffrey M Hausdorff, Jonathan F Bean, Brad Manor, Robert R McLean, Tongjian You
This cross-sectional study examines the association between chronic musculoskeletal pain and foot reaction time (RT) among older community-living adults. Participants were 307 adults aged 71 years and older in the MOBILIZE Boston Study II. Pain severity, interference, and location were measured by the Brief Pain Inventory and a joint pain questionnaire. With participants seated, simple foot reaction time was measured as self-selected foot response time to an intermittent light, and choice foot reaction time was measured as response time to the light on the corresponding side of the sensored gait mat...
June 26, 2020: Journal of Pain
Michael A Wewege, Matthew D Jones
Exercise-induced hypoalgesia (EIH) is a reduction in pain that occurs during or following exercise. Randomised controlled studies published from 1980 to January 2020 that examined experimentally induced pain before and during/following a single bout of exercise in healthy individuals or people with chronic musculoskeletal pain were systematically reviewed. Data were analysed using random-effects meta-analyses and studies were appraised using the Cochrane Risk of Bias tool and GRADE. 5829 records were screened, with 13 studies ultimately included...
June 26, 2020: Journal of Pain: Official Journal of the American Pain Society
Verina Hanna, Helen Senderovich
Adequate analgesia can be challenging, as pharmacological options are not necessarily effective for all types of pain and are associated with adverse effects. Methadone is increasingly being considered in the management of both cancer-related and noncancer-related pain. The purpose of this article is to provide a narrative review of all available randomized controlled trials (RCTs) investigating the effectiveness of methadone in the management of pain, in relation to a comparison drug. The primary outcome was analgesic effectiveness, and the secondary outcomes were side effects and cost...
June 26, 2020: Journal of Pain: Official Journal of the American Pain Society
Qimiao Hu, Xiaoli Zheng, Xiaojie Li, Boyu Liu, Chengyu Yin, Yuanyuan Li, Ruixiang Chen, Jie Wang, Yi Liang, Xiaomei Shao, Jianqiao Fang, Boyi Liu
Complex regional pain syndrome (CRPS) results in chronic and excruciating pain in patients. Conventional therapies lack effectiveness, rendering it one of the most difficult to treat neurological conditions.. Electroacupuncture (EA) is an effective alternative therapy for pain relief. Here, we investigated whether EA exerts analgesic effect on a rat model of CRPS type-I (CRPS-I) and related mechanisms. The rat chronic postischemic pain (CPIP) model was established to mimic CRPS-I. 100Hz EA exerted robust and persistent antiallodynic effect on CPIP model compared with 2 Hz EA or sham EA...
June 25, 2020: Journal of Pain: Official Journal of the American Pain Society
James A Watson, Cormac G Ryan, Greg Atkinson, Philip Williamson, Dominic Ellington, Robbie Whittle, John Dixon, Denis J Martin
Pain neuroscience education (PNE) is an approach used in the management of chronic musculoskeletal pain. Previous reviews on PNE and other pain interventions, have focused on mean treatment effects, but in the context of "precision medicine," any inter-individual differences in treatment response are also important to quantify. If inter-individual differences are present, and predictors identified, PNE could be tailored to certain people for optimizing effectiveness. Such heterogeneity can be quantified using recently formulated approaches for comparing the response variance between the treatment and control groups...
June 22, 2020: Journal of Pain: Official Journal of the American Pain Society
Lianne Wood, Nadine E Foster, Martyn Lewis, Annette Bishop
Exercise is a core treatment for persistent non-specific low back pain (NSLBP), but results from randomised controlled trials (RCTs) of exercise typically show only small to moderate standardised mean differences (SMDs) compared to nonexercise controls. The choice of primary outcome, and relationship to the specific targets of exercise may influence this. This systematic review aimed to explore whether primary outcomes match the exercise treatment targets used in NSLBP RCTs and the potential impact of matching on SMDs...
June 21, 2020: Journal of Pain: Official Journal of the American Pain Society
Constance A Mara, Susmita Kashikar-Zuck, Natoshia Cunningham, Kenneth R Goldschneider, Bin Huang, Carlton Dampier, David D Sherry, Lori Crosby, Jennifer Farrell Miller, Kimberly Barnett, Esi M Morgan
The goal of the current study was to enhance the measurement of the pediatric chronic pain experience through a methodologically rigorous approach. This paper outlines the development and initial validation of a pain intensity measure for pediatric patients with chronic pain using Patient-Reported Outcomes Measurement Information System methodology. Measure development incorporated feedback from children with painful conditions. Based on input from pediatric participants and content experts, 4 candidate items assessing pain intensity were included for large scale testing...
June 21, 2020: Journal of Pain
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