Juliet Mwirigi, Moeno Kume, Shayne N Hassler, Ayesha Ahmad, Pradipta R Ray, Changyu Jiang, Alexander Chamessian, Nakleh Mseeh, Breya P Ludwig, Benjamin D Rivera, Marvin T Nieman, Thomas Van de Ven, Ru-Rong Ji, Gregory Dussor, Scott Boitano, Josef Vagner, Theodore J Price
The protease activated receptor (PAR) family is a group of G-protein coupled receptors (GPCRs) activated by proteolytic cleavage of the extracellular domain. PARs are expressed in a variety of cell types with crucial roles in hemostasis, immune responses, inflammation, and pain. PAR3 is the least researched of the four PARs, with little known about its expression and function. We sought to better understand its potential function in the peripheral sensory nervous system. Mouse single-cell RNA sequencing data demonstrates that PAR3 is widely expressed in dorsal root ganglion (DRG) neurons...
January 8, 2021: Journal of Pain
Pan Gu, Tingting Fan, Stanley Sau Ching Wong, Zhiqiang Pan, Wai Lydia Tai, Sookja Kim Chung, Chi Wai Cheung
The rationale of spinal administration of endothelin-1(ET-1) mediated anti-nociceptive effect has not been elucidated. ET-1 is reported to promote nuclear effluxion of histone deacetylase 5 (HDAC5) in myocytes, and spinal HDAC5 is implicated in modulation of pain processing. In this study, we aimed to investigate whether central ET-1 plays an anti-nociceptive role by facilitating spinal HDAC5 nuclear shuttling under neuropathic pain. Here, we demonstrate that upregulating spinal ET-1 attenuated the nociception induced by partial sciatic nerve ligation (pSNL) surgery and this analgesic effect mediated by ET-1 was attenuated by intrathecal injection of endothelin A receptor (ETAR) selective inhibitor (BQ123) or by blocking the exportation of nuclear HDAC5 by adeno-associated viruses targeting neuronal HDAC5 (AVV-HDAC5 S259/498A Mutant)...
January 6, 2021: Journal of Pain
S Strauss, S Barby, J Härtner, N Neumann, G L Moseley, M Lotze
Complex regional pain syndrome (CRPS) is a neuropathic pain condition that is difficult to treat. For behavioral interventions, graded motor imagery (GMI) showed relevant effects, but underlying neural substrates in patient groups have not been investigated yet. A previous study investigating differences in the representation of a left/right hand judgment task demonstrated less recruitment of subcortical structures, such as the putamen, in CRPS patients than in healthy controls. In healthy volunteers, the putamen activity increased after a hand judgment task training...
January 6, 2021: Journal of Pain
Richard J Berwick, Sara Siew, David A Andersson, Andrew Marshall, Andreas Goebel
Fibromyalgia syndrome (FMS) is a chronic widespread pain condition of unknown aetiology. The role of temperature in FMS pain has not been reviewed systematically. The goal of this study was to review the influences of temperature on pain in FMS, from meteorological and quantitative sensory testing (QST) studies. The review was registered with Prospero: ID-CRD42020167687, and followed PRISMA guidance. Databases interrogated were: MEDLINE (via OVID), EMBASE, PubMed, Web of Science, ScienceDirect, CINAHL and ProQuest (Feb'20)...
January 6, 2021: Journal of Pain
Katie A Butera, Mark D Bishop, Warren H Greenfield, Roland Staud, Margaret R Wallace, Paul A Borsa, Roger B Fillingim, Steven Z George
Our prior studies identified a high-risk phenotype (i.e. high pain sensitivity variant of the catechol-O-methyltransferase (COMT) gene (SNP rs6269) and pain catastrophizing scores) for shoulder pain. The current study identified sensory and psychological predictors of heightened pain responses following exercise-induced shoulder injury. Healthy participants (N=131) with the SNP rs6269 COMT gene and Pain Catastrophizing Scale scores ≥5 underwent baseline sensory and psychological testing followed by an established shoulder fatigue protocol, to induce muscle injury...
January 2, 2021: Journal of Pain
Kevin F Boehnke, Joel J Gagnier, Lynne Matallana, David A Williams
Cannabidiol (CBD) is widely advertised as helpful for chronic pain management but research is limited. Using a cross-sectional, anonymous survey, we examined patterns of naturalistic CBD use among individuals with fibromyalgia (FM) and other chronic pain conditions. Our objective was to better understand rates of CBD use, reasons for use and discontinuation, communication with healthcare professionals about CBD, and perceptions of CBD effectiveness and safety among people with FM. After excluding incomplete surveys, our study population consisted of N = 2701 participants with fibromyalgia, primarily in the United States...
January 2, 2021: Journal of Pain
Kylie Isenburg, Ishtiaq Mawla, Marco L Loggia, Dan-Mikael Ellingsen, Ekaterina Protsenko, Matthew H Kowalski, David Swensen, Deanna O'Dwyer-Swensen, Robert R Edwards, Vitaly Napadow, Norman Kettner
Chronic low back pain (cLBP) has been associated with changes in brain plasticity. Non-pharmacological therapies such as Manual Therapy (MT) have shown promise for relieving cLBP. However, translational neuroimaging research is needed to understand potential central mechanisms supporting MT. We investigated the effect of MT on resting-state salience network (SLN) connectivity, and whether this was associated with changes in clinical pain. Fifteen cLBP patients, and 16 matched healthy controls (HC) were scanned with resting functional Magnetic Resonance Imaging (fMRI), before and immediately after a MT intervention (cross-over design with two separate visits, pseudorandomized, grades V 'Manipulation' and III 'Mobilization' of the Maitland Joint Mobilization Grading Scale)...
December 12, 2020: Journal of Pain
N Kerckhove, C Lambert, A Corteval, B Pereira, A Eschalier, C Dualé
Chronic pain prevention and treatment constitute a challenge for occupational health. The aim of this study was to provide data on workers in a variety of jobs and multiple contexts to determine the prevalence and characteristics of different chronic pain disorders, in view to highlighting possible new targets for preventive actions. 1,008 participants working in 14 French IKEA stores were analyzed in this observational study on the basis of their responses to surveys on their sociodemographic characteristics, psychosocial factors, lifestyle and pain disorders...
December 10, 2020: Journal of Pain
Audrius Parseliunas, Saulius Paskauskas, Egle Kubiliute, Jovydas Vaitekunas, Donatas Venskutonis
In this randomized, double-blind, placebo-controlled trial, we evaluated the role of transcutaneous electrical nerve stimulation (TENS) in the multimodal treatment (non-opioid analgesics and kinesiotherapy) of postoperative pain following open inguinal hernia repair. In total, 80 males participants with elective primary unilateral hernia Lichtenstein repair were randomly allocated to receive TENS or a placebo-TENS procedure. The TENS group received local and segmental conventional TENS on the first and second postoperative days...
December 10, 2020: Journal of Pain
Julie M Fritz, Jason Sharpe, Tom Greene, Elizabeth Lane, Maliheh Hadizadeh, Molly McFadden, Douglas Santillo, Jedidiah Farley, Jake Magel, Anne Thackeray, Gregory Kawchuk
Spinal manipulative therapy (SMT) is a common nonpharmacologic treatment for low back pain (LBP). Although generally supported by systematic reviews and practice guidelines, clinical trials evaluating SMT have been characterized by small effect sizes. This study adopts a multiphase optimization strategy (MOST) framework to examine individual components of an SMT delivery protocol using a single-blind trial with the goal of identifying and optimizing a multi-component SMT protocol. We enrolled 241 participants with LBP...
December 10, 2020: Journal of Pain
P Maxwell Slepian, Christopher R France, Jamie L Rhudy, Brian C Clark
Emotion has a strong modulatory effect on pain perception and spinal nociception. Pleasure inhibits pain and nociception, whereas displeasure facilitates pain and nociception. Dysregulation of this system has been implicated in development and maintenance of chronic pain. The current study sought to examine whether emotional modulation of pain could be altered through the use of transcranial direct current stimulation (tDCS) to enhance (via anodal stimulation) or depress (via cathodal stimulation) cortical excitability in the dorsolateral prefrontal cortex...
November 27, 2020: Journal of Pain
Ivan J M Bonet, Dionéia Araldi, Oliver Bogen, Jon D Levine
TACAN (Tmem120A), a mechanotransducing ion channel highly expressed in a subset of nociceptors, has recently been shown to contribute to detection of noxious mechanical stimulation. In the present study we evaluated its role in sensitization to mechanical stimuli associated with preclinical models of inflammatory and chemotherapy-induced neuropathic pain (CIPN). Intrathecal administration of an oligodeoxynucleotide antisense (AS-ODN) to TACAN mRNA attenuated TACAN protein expression in rat dorsal root ganglia (DRG)...
November 21, 2020: Journal of Pain
Blake F Dear, Eyal Karin, Rhiannon Fogliati, Joanne Dudeney, Olav Nielssen, Amelia J Scott, Milena Gandy, Madelyne A Bisby, Andreea I Heriseanu, Taylor Hathway, Lauren Staples, Nickolai Titov, Liz Schroeder
There is growing interest in the potential of internet-delivered pain management programs (PMPs) to increase access to care for people with chronic pain. However, very few economic evaluations of these interventions have been reported. Using existing data, the current study examined the cost-effectiveness of an internet-delivered PMP for a mixed group chronic pain patients (n = 490) provided with different levels of clinician support. The findings indicated that each additional clinical outcome (defined as a ≥ 30% reduction in disability, depression, anxiety and pain) was associated with cost-savings when the intervention was provided in a self-guided format (ICER range: -$404 to -$808 AUD) or an optional-guided format (ICER range: -$314 to -$541 AUD), and a relatively small fixed cost when provided in the clinician-guided format (ICER range: $88 to $225 AUD)...
November 20, 2020: Journal of Pain
Anne-Laure Genevois, Jérôme Ruel, Virginie Penalba, Séverine Hatton, Camille Petitfils, Myriam Ducrocq, Paola Principe, Gilles Dietrich, Céline Greco, Patrick Delmas
Oral amitriptyline hydrochloride (amitriptyline) is ineffective against some forms of chronic pain and is often associated with dose-limiting adverse events. We evaluated the potential effectiveness of high-dose topical amitriptyline in a preliminary case series of chemotherapy-induced peripheral neuropathy (CIPN) patients and investigated whether local or systemic adverse events associated with the use of amitriptyline were present in these patients. We also investigated the mechanism of action of topically administered amitriptyline in mice...
November 20, 2020: Journal of Pain
Taichi Goto, Matthew R Sapio, Dragan Maric, Jeffrey M Robinson, Leorey N Saligan, Andrew J Mannes, Michael J Iadarola
Pain is a common but potentially debilitating symptom, often requiring complex management strategies. To understand the molecular dynamics of peripheral inflammation and nociceptive pain, we investigated longitudinal changes in behavior, tissue structure, and transcriptomic profiles in the rat carrageenan-induced peripheral inflammation model. Sequential changes in the number of differentially expressed genes are consistent with temporal recruitment of key leukocyte populations, mainly neutrophils and macrophages with each wave being preceded by upregulation of the cell-specific chemoattractants, Cxcl1 and Cxcl2, and Ccl2 and Ccl7, respectively...
November 20, 2020: Journal of Pain
Mathew S Ellis, Zachary Kasper, Theodore Cicero
Chronic pain is a significant comorbid condition among individuals with opioid use disorder (OUD). However, due to conflicting perceptions of responsibility, structural barriers, and a lack of widely applied standards of care, it is unclear what the landscape of chronic pain management looks like in addiction medicine. Using a national opioid surveillance system, we analyzed survey data from new entrants (n=14,449) to 225 OUD treatment centers from 2013 to 2018, as well as an online survey among a subset of respondents (n=309)...
November 13, 2020: Journal of Pain
Edward W Lannon, Fabricio A Jure, Ole Kæseler Andersen, Jamie L Rhudy
Threat-induced pain modulation can increase survival by amplifying physiological and behavioral reactions towards danger. Threat can also modulate spinal nociception, suggesting engagement of endogenous top-down circuitry. A unique method to assess spinal nociception is via reflex receptive fields (RRF) associated with the nociceptive withdrawal reflex (NWR, a protective spinally-mediated reflex). The size of nociceptive RRFs can be modulated by top-down circuitry with the enlargement of RRFs related to increased spinal nociception...
November 6, 2020: Journal of Pain
Victoria Wai-Lan Yeung, Andrew L Geers
A recent study found that merely possessing a placebo analgesic reduces pain. The current study tested for a possible moderator of this effect. Specifically, does the mere possession of a placebo analgesic affect pain for individuals with and without immediate prior experience with the pain task? Healthy participants (N=127) were randomized to prior pain (PP) condition or without prior pain (No-PP) condition. In the PP condition, participants first did a preliminary trial of a cold pressor test (CPT) to induce direct experience with this pain stimulus...
October 27, 2020: Journal of Pain
Stefan Schneider, Doerte U Junghaenel, Joan E Broderick, Masakatsu Ono, Marcella May, Arthur A Stone
Pain intensity is a complex and dynamic experience. A focus on assessing patients' average pain levels may miss important aspects of pain that impact functioning in daily life. In this second of 3 articles investigating alternative indices of pain intensity derived from Ecological Momentary Assessments (EMA), we examine the indices' associations with physical and psychosocial functioning. EMA data from 10 studies (2,660 patients) were reanalyzed to construct indices of Average Pain, Maximum Pain, Minimum Pain, Pain Variability, Time in High Pain, Time in Low Pain, Pain after Wake-up...
October 24, 2020: Journal of Pain
Stefan Schneider, Doerte U Junghaenel, Masakatsu Ono, Joan E Broderick, Arthur A Stone
Pain intensity represents the primary outcome in most pain clinical trials. Identifying methods to measure aspects of pain that are most sensitive to treatment may facilitate discovery of effective interventions. In this third of 3 articles examining alternative indices of pain intensity derived from ecological momentary assessments (EMA), we compare treatment effects based on Average Pain, Maximum Pain, Minimum Pain, Pain Variability, Time in High Pain, Time in Low Pain, and Pain After Wake-Up. We also examine which indices contribute to Patient Global Impressions of Change (PGIC)...
October 24, 2020: Journal of Pain
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