Chloe-Emily Eather, Matthew J Gullo, Rachel A Elphinston
Depression, a prognostic factor for prescription opioid misuse commonly occurs in people with chronic non-cancer pain (CNCP). However, the mechanisms linking depression and prescription opioid misuse remain unclear. This study examined the potential mediating role of pain catastrophizing in the association between depressive symptoms and prescription opioid misuse risk, and impulsivity traits as possible moderators of these relationships. Individuals (N = 198; 77% women) with CNCP using prescription opioids participated in a cross-sectional online survey with validated measures of depression, pain catastrophizing, rash impulsiveness, reward drive, anxiety, pain severity and prescription opioid misuse...
November 25, 2022: Journal of Pain
Felicia Ta Sundström, Amani Lavefjord, Monica Buhrman, Lance M McCracken
Psychological flexibility (PF) is a model of well-being and daily functioning that is applied to chronic pain, and is the model behind Acceptance and Commitment Therapy (ACT). However, studies of PF in chronic pain are limited by the lack of a single measure capturing all facets. The Multidimensional Psychological Flexibility Inventory (MPFI) assesses all facets of PF and psychological inflexibility (PI) and could remedy this problem. The current study employs this measure. Adult participants with chronic pain (N = 404) were recruited online and completed the MPFI, other validated measures of PF/PI, and measures of pain, work and social adjustment, and depression, at two time points...
November 25, 2022: Journal of Pain
Chencai Wang, Jason J Kutch, Jennifer S Labus, Claire C Yang, Richard E Harris, Emeran A Mayer, Benjamin M Ellingson
Microstructural alterations have been reported in patients with urologic chronic pelvic pain syndrome (UCPPS). However, it isn't clear whether these alterations are reproducible within 6 months or whether long-term symptom improvement is associated with specific microstructural changes. Using data from the MAPP-II Research Network, the current study performed population-based voxel-wise DTI and probabilistic tractography in a large sample of participants from the multicenter cohort with UCPPS (N=364) and healthy controls (HCs, N=61) over 36 months...
November 23, 2022: Journal of Pain
Erin Kelty, Mishka Terplan, Carol Orr, David B Preen
Oxycodone is commonly used by pregnant women for the treatment of pain. However, the potential risk associated with its use in pregnancy have not been robustly evaluated. The objective of this study was to examine neonatal outcomes associated with prenatal oxycodone exposure. State dispensing records were matched with midwives records to identify women who had been dispensed oxycodone during pregnancy (n=302). A matched comparison group of women who had been prescribed oxycodone prior to pregnancy was also identified (n=604)...
November 21, 2022: Journal of Pain
Moeno Kume, Ayesha Ahmad, Stephanie Shiers, Michael D Burton, Kathryn A DeFea, Josef Vagner, Gregory Dussor, Scott Boitano, Theodore J Price
Given the limited options and often harmful side effects of current analgesics and the suffering caused by the opioid crisis, new classes of pain therapeutics are needed. Protease-activated receptors (PARs), particularly PAR2, are implicated in a variety of pathologies, including pain. Since the discovery of the role of PAR2 in pain, development of potent and specific antagonists has been slow. In this study, we describe the in vivo characterization of a novel small molecule/peptidomimetic hybrid compound, C781, as a β-arrestin-biased PAR2 antagonist...
November 20, 2022: Journal of Pain
Lakeya S McGill, Katrina R Hamilton, Janelle E Letzen, Patrick H Finan, Sophie M Lanzkron, Michael T Smith, Jennifer A Haythornthwaite, Claudia M Campbell
Racism-based discrimination in healthcare settings has been associated with clinical pain in adults living with sickle cell disease (SCD); however, no studies have examined depressive and insomnia symptoms as mechanisms that may drive this relationship. This secondary data analysis examined associations between depressive and insomnia symptoms, racism-based discrimination, and clinical pain. Seventy-one adults with SCD (70% female, Mage  = 38.79) provided baseline reports of racism-based discrimination, depressive symptoms, insomnia symptoms, and pain (severity, interference, catastrophizing), and they completed daily diaries of pain severity and interference over three months...
November 19, 2022: Journal of Pain
Milton Cohen, Asaf Weisman, John Quintner
No abstract text is available yet for this article.
November 15, 2022: Journal of Pain
Sónia F Bernardes, Alexandra Rei, Helena Carvalho
Assessing family supportive responses to pain behaviors is paramount, as these may help or hinder chronic pain (CP) adjustment. Current self-report measures of pain-specific family supportive dynamics are scarce, covering a limited range of responses. To address this gap, this paper aimed at the psychometric validation of a (revised) novel measure - the Informal Social Support for Autonomy and Dependence in Pain Inventory (ISSADI-PAIN). Three-hundred and three adults participated in this study (53.3% women; Mage =49...
November 10, 2022: Journal of Pain
Ishwarya Sankaranarayanan, Diana Tavares- Ferreira, Lucy He, Moeno Kume, Juliet Mwirigi, Torsten M Madsen, Kenneth A Petersen, Gordon Munro, Theodore J Price
Chemotherapy-induced peripheral neuropathy (CIPN) is a challenging condition to treat, and arises due to severe, dose-limiting toxicity of chemotherapeutic drugs such as paclitaxel. This often results in debilitating sensory and motor deficits that are not effectively prevented or alleviated by existing therapeutic interventions. Recent studies have demonstrated the therapeutic effects of Meteorin, a neurotrophic factor, in reversing neuropathic pain in rodent models of peripheral nerve injury induced by physical trauma...
November 3, 2022: Journal of Pain
Wouter Schuller, Caroline B Terwee, Berend Terluin, Daphne Rohrich, Raymond W J G Ostelo, Henrica C W de Vet
We evaluated the responsiveness of the PROMIS Pain Interference item bank in patients with musculoskeletal pain by testing predefined hypotheses about the relationship between the change scores on the item bank, change scores on legacy instruments and Global Ratings of Change (GRoC), and we estimated Minimal Important Change (MIC). Patients answered the full Dutch-Flemish V1.1 item bank. From the responses we derived scores for the standard 8-item short form (SF8a) and a CAT-score was simulated. Correlations between the change scores on the item bank, GRoC and legacy instruments were calculated, together with Effect Sizes (ES), Standardized Response Means (SRM), and Area Under the Curve (AUC)...
November 3, 2022: Journal of Pain
Ryou Toyota, Haruka Ito, Yukito Sashide, Mamoru Takeda
Although the modulatory effect of quercetin on voltage-gated Na, K and Ca channels has been studied in vitro, the in vivo effect of quercetin on the excitability of nociceptive primary neurons remains to be determined. The aim of the present study was to examine whether acute local quercetin administration to rats attenuates the excitability of nociceptive trigeminal ganglion (TG) neurons in response to mechanical stimulation in vivo. Extracellular single unit recordings were made from TG neurons of anesthetized rats in response to orofacial non-noxious and noxious mechanical stimulation...
November 2, 2022: Journal of Pain
Patricia M Herman, Nabeel Qureshi, Susan D Arick, Maria O Edelen, Ron D Hays, Anthony Rodriguez, Rebecca L Weir, Ian D Coulter
Among those with low back pain (LBP), individuals with chronic LBP (CLBP) face different treatment recommendations and incur the majority of suffering and costs. However, the way CLBP has been defined varies greatly. This study used a scoping review and qualitative and quantitative analyses of data from LBP patients to explore this variation. CLBP in most recent randomized controlled trials (RCTs) was defined by duration of pain, most commonly ≥3 months. However, individuals with LBP most often define CLBP by frequency...
October 23, 2022: Journal of Pain
Laurent F Martin, Kevin Cheng, Stephanie M Washington, Millie Denton, Vasudha Goel, Maithili Khandekar, Tally M Largent-Milnes, Amol Patwardhan, Mohab M Ibrahim
Light therapy improves multiple conditions such as seasonal affective disorders, circadian rhythm dysregulations, and neurodegenerative diseases. However, little is known about its potential benefits in pain management. While current pharmacologic methods are effective in many cases, the associated side effects can limit their use. Non-pharmacological methods would minimize drug dependence, facilitating a reduction of the opioid burden. Green light therapy has been shown to be effective in reducing chronic pain in humans and rodents...
October 22, 2022: Journal of Pain
Cindy Stroemel-Scheder, Stefan Lautenbacher
Recent research suggests that recovery sleep (RS) has the potential to restore pain sensitivity and modulation after hyperalgesia due to preceding sleep deprivation. However, it has not yet been systematically examined whether the restoration of these pain parameters is driven by sleep characteristics of RS. Thus, the present study assessed changes in experimental pain during RS after total sleep deprivation (TSD) to test whether RS parameters predicted the restoration of the pain system. Thirty healthy participants completed one night of habitual sleep, one night of TSD and a subsequent recovery night...
October 20, 2022: Journal of Pain
Anne E Sanders, E Diane Weatherspoon, Brandie M Ehrmann, Paul S Soma, Saame R Shaikh, John S Preisser, Richard Ohrbach, Roger B Fillingim, Gary D Slade
Pain intensity is well-known to be influenced by a wide range of biobehavioral variables. Nutritional factors, however, have not been generally considered for their potential importance. This cross-sectional study examined associations between erythrocyte omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFAs) and pain intensity in 605 adults. Pain intensity was computed on a 0-100 numeric rating scale from questions about five chronic pain conditions: orofacial pain, headache, low back pain, irritable bowel syndrome, and bodily pain...
October 20, 2022: Journal of Pain
Martin Diers, Xaver Fuchs, Robin Bekrater-Bodmann, Herta Flor
Phantom limb pain (PLP) is a common consequence of the amputation of a limb. Persons with congenital limb absence (congenital amputees) or an acquired limb amputation at an early age seem to rarely experience PLP. However, the number of available studies and their sample sizes are low. In the present cross-sectional study, we assessed the presence of several phantom phenomena in a sample of 99 adult unilateral congenital amputees (con) of whom 34 had a limb correction later in life (limbc) and 153 adult participants with a unilateral amputation before the age of 6 years (subgroups: amputation between birth and 2 years (0-2y; n = 48), 3-4 years (3-4y; n = 46), and 5-6 years (5-6y; n = 59))...
October 20, 2022: Journal of Pain
Zhong Chen, Yuan Liu, Xianhe Wu, Wei Lin, Zihan Liu, Yang Huang, Yu Chen, Ying Tang, Aiqin Chen, Chun Lin
Dysregulation of circular RNAs (circRNAs) has been reported to be functionally associated with chronic pain, but it is unknown whether and how circRNAs participate in visceral hypersensitivity. The expression of circKcnk9 was increased in spinal neurons of IBS-like rats. ShcircKcnk9 attenuated visceral hypersensitivity and inhibited c-Fos expression in IBS-like rats, whereas overexpression of spinal circKcnk9 induced visceral hypersensitivity and increased c-Fos expression in control rats. Furthermore, circKcnk9 was found to act as a miR-124-3p sponge...
October 15, 2022: Journal of Pain
Xiaobao Ding, Yuwen Lin, Binbin Yan, Xiaowei Jiao, Qiang Liu, Huihui Miao, Yuqing Wu, Chenghua Zhou
Chronic pain is frequently comorbid with depression. However, the mechanisms underlying chronic pain-induced depression remain unclear. Here, we found that DNA methyltransferase 1 (DNMT1) was upregulated in the central amygdala (CeA) of spared nerve injury (SNI)-induced chronic pain-depression rats, and knockdown of DNMT1 could improve the depression-like behaviors in SNI rats. Additionally, a panel of differentially expressed lncRNAs, including 38 upregulated and 12 downregulated lncRNAs, were identified by microarray analysis...
October 15, 2022: Journal of Pain
Scott F Farrell, Pik-Fang Kho, Mischa Lundberg, Adrián I Campos, Miguel E Rentería, Rutger M J de Zoete, Michele Sterling, Trung Thanh Ngo, Gabriel Cuéllar-Partida
The multiple comorbidities & dimensions of chronic pain present a formidable challenge in disentangling its aetiology. Here, we performed genome-wide association studies of eight chronic pain types using UK Biobank data (N=4,037-79,089 cases; N=239,125 controls), followed by bivariate linkage disequilibrium-score regression and latent causal variable analyses to determine (respectively) their genetic correlations and genetic causal proportion (GCP) parameters with 1,492 other complex traits. We report evidence of a shared genetic signature across chronic pain types as their genetic correlations and GCP directions were broadly consistent across an array of biopsychosocial traits...
October 14, 2022: Journal of Pain
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