Journal of Pain

John D Markman, Katarzyna Czerniecka-Foxx, Partap S Khalsa, Salim Michel Hayek, Anthony L Asher, John D Loeser, Roger Chou
Chronic low back pain conditions are highly prevalent and constitute the leading cause of disability worldwide. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks (ACTTION) public-private partnership with the US Food and Drug Administration and the American Pain Society (APS), have combined to create the ACTTION-APS Pain Taxonomy (AAPT). The AAPT initiative convened a working group to develop diagnostic criteria for chronic low back pain. The working group identified three distinct low back pain conditions which result in a vast public health burden across the lifespan...
February 6, 2020: Journal of Pain: Official Journal of the American Pain Society
Mark C Bicket, Michael C Grant, Michael J Scott, Gregory W Terman, Elizabeth C Wick, Christopher L Wu
Abdominal and peritoneal pain after surgery is common and burdensome, yet the lack of standardized diagnostic criteria for this type of acute pain impedes basic, translational, and clinical investigations. The collaborative effort among the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION), American Pain Society (APS), and American Academy of Pain Medicine (AAPM) Pain Taxonomy (AAAPT) provides a systematic framework to classify acute painful conditions...
January 29, 2020: Journal of Pain: Official Journal of the American Pain Society
Meghan A Rossi, Jessica A Maxwell, Natalie O Rosen
Postpartum pain during intercourse is a prevalent and distressing problem that has substantial consequences for affected couples. Partner perceptions-such as how partners perceive women's pain self-efficacy-contribute to an individual's pain experience. This study examined whether partners under- or over-estimate women's intercourse pain self-efficacy at three months postpartum and the implications of this bias for women's pain and couples' sexual functioning at three and six months postpartum. Women who reported pain during intercourse and their partners (N = 89 couples) completed online measures assessing pain self-efficacy (own or partner perceptions), pain intensity, and sexual functioning at three and six months postpartum...
January 29, 2020: Journal of Pain
Michael C Rowbotham, Mark Wallace
Contributors to the ongoing epidemic of prescription opioid abuse, addiction, and death include opioid tolerance, withdrawal symptoms, and possibly opioid-induced hyperalgesia (OIH). Thirty stable chronic non-malignant pain patients entered a six-month long, randomized, double-blind, dose-response, two-center trial of the potent opioid levorphanol, conducted over a decade ago during an era of permissive opioid prescribing. Eleven were taking no opioids at study entry and eleven were taking between 35-122 morphine equivalents (MEQ)...
January 29, 2020: Journal of Pain: Official Journal of the American Pain Society
Qimiao Hu, Xiaoli Zheng, Xiaojie Li, Boyu Liu, Chengyu Yin, Yuanyuan Li, Ruixiang Chen, Jie Wang, Yi Liang, Xiaomei Shao, Jianqiao Fang, Boyi Liu
Complex regional pain syndrome (CRPS) results in chronic and excruciating pain in patients. Conventional therapies lack effectiveness, rendering it one of the most difficult to treat neurological conditions.. Electroacupuncture (EA) is an effective alternative therapy for pain relief. Here, we investigated whether EA exerts analgesic effect on a rat model of CRPS type-I (CRPS-I) and related mechanisms. The rat chronic post-ischemic pain (CPIP) model was established to mimic CRPS-I. 100Hz EA exerted robust and persistent anti-allodynic effect on CPIP model compared with 2Hz EA or sham EA...
January 29, 2020: Journal of Pain: Official Journal of the American Pain Society
H Cramer, P Klose, M Teut, G Rotter, M Ortiz, D Anheyer, K Linde, B Brinkhaus
There is a growing interest in non-pharmacological pain treatment options such as cupping. This meta-analysis aimed to assess the effectiveness and safety of cupping in chronic pain. PubMed, Cochrane Library, and Scopus were searched through November 2018 for randomized controlled trials on effects of cupping on pain intensity and disability in patients with chronic pain. Risk of bias was assessed using the Cochrane risk-of-bias tool. Of the 18 included trials (n=1,172), most were limited by clinical heterogeneity and risk of bias...
January 23, 2020: Journal of Pain: Official Journal of the American Pain Society
Donna M Lloyd, Priscilla G Wittkopf, Laura J Arendsen, Anthony K P Jones
BACKGROUND: Fibromyalgia is a debilitating condition characterized by chronic widespread pain. It is believed to be caused by dysfunction of the central nervous system (CNS) but current treatments are largely ineffective. Transcranial Direct Current Stimulation (tDCS), a neuromodulation technique that targets the CNS, may offer a new line of treatment. OBJECTIVE: To systematically review the most up-to-date literature and perform a meta-analysis of the effects of tDCS on pain intensity in fibromyalgia...
January 23, 2020: Journal of Pain: Official Journal of the American Pain Society
Kangwon Song, Chen-Pin Wang, Donald D McGeary, Carlos A Jaramillo, Blessen C Eapen, Megan Amuan, Cindy A McGeary, Jennifer S Potter, Mary Jo V Pugh
Pain is a pervasive problem that affects nearly half of the U.S. Veterans deployed in support of the Global War on Terror (Post-9/11 Veterans) and over half of the Post-9/11 Veterans with diagnosed traumatic brain injury (TBI). The goal of the current study was to identify pain phenotypes based on distinct longitudinal patterns of pain scores in light of pain treatment among Post-9/11 Veterans over five years of care using latent growth mixture analysis stratified by TBI status. Five pain phenotypes emerged: (1) simple low impact stable pain, (2) complex low impact stable pain, (3) complex low impact worsening pain, (4) complex moderate impact worsening pain, and (5) complex high impact stable pain...
January 22, 2020: Journal of Pain
Hassan Jafari, Ali Gholamrezaei, Mathijs Franssen, Lukas Van Oudenhove, Qasim Aziz, Omer Van den Bergh, Johan W S Vlaeyen, Ilse Van Diest
Slow deep breathing (SDB) is commonly employed in the management of pain, but the underlying mechanisms remain equivocal. This study sought to investigate effects of instructed breathing patterns on experimental heat pain and to explore possible mechanisms of action. In a within-subject experimental design, healthy volunteers (n = 48) performed four breathing patterns: 1) unpaced breathing (UB), 2) paced breathing at the participant's spontaneous breathing frequency (PB), 3) SDB at six breaths per minute with a high inspiration/expiration ratio (SDB-H), and 4) SDB at six breaths per minute with a low inspiration/expiration ratio (SDB-L)...
January 21, 2020: Journal of Pain: Official Journal of the American Pain Society
Matthew R Sapio, Michael J Iadarola, Amelia J Loydpierson, Jenny J Kim, Danielle Thierry-Mieg, Jean Thierry-Mieg, Dragan Maric, Andrew J Mannes
Understanding molecular alterations associated with peripheral inflammation is a critical factor in selectively controlling acute and persistent pain. The present report employs in situ hybridization of the two opioid precursor mRNAs coupled with quantitative measurements of two peptides derived from the prodynorphin and proenkephalin precursor proteins: dynorphin A 1-8 and [Met5 ]-enkephalin-Arg6 -Gly7 -Leu8 (MERGL). In dorsal spinal cord ipsilateral to the inflammation, dynorphin A 1-8 was elevated after inflammation, and persisted as long as the inflammation was sustained...
January 10, 2020: Journal of Pain: Official Journal of the American Pain Society
Lingli Liang, Shaogen Wu, Corinna Lin, Yun-Juan Chang, Yuan-Xiang Tao
NrCAM, a neuronal cell adhesion molecule in the L1 family of the immunoglobulin superfamily, is subjected to extensively alternative splicing and is involved in neural development and some disorders. The aim of this study was to explore the role of Nrcam mRNA alternative splicing in neuropathic pain. A next generation RNA sequencing analysis of dorsal root ganglions (DRGs) showed the differential expression of two splicing variants of Nrcam, Nrcam+10 and Nrcam-10 , in the injured DRG after the fourth lumbar spinal nerve ligation (SNL)...
January 6, 2020: Journal of Pain: Official Journal of the American Pain Society
Yuval Argaman, Lee B Kisler, Yelena Granovsky, Robert C Coghill, Elliot Sprecher, David Manor, Irit Weissman-Fogel
Altered pain modulation and resting state functional connectivity (rsFC) were found to be related to migraine pathology and clinical manifestation. We examined how pain modulation psychophysical measures are related to resting-state networks and rsFC between bottom-up and top-down pain modulation areas. Thirty-two episodic migraineurs and 23 age-matched healthy individuals underwent temporal summation of pain (TSOP) and conditioned pain modulation (CPM) tests, followed by a resting-state imaging scan. No differences in temporal summation of pain and CPM were found between groups...
January 3, 2020: Journal of Pain: Official Journal of the American Pain Society
Simona Maccora, Nadia Bolognini, Giuseppe Cosentino, Roberta Baschi, Giuseppe Vallar, Brigida Fierro, Filippo Brighina
Multisensory processing can be assessed by measuring susceptibility to crossmodal illusions such as the Sound-Induced Flash Illusion (SIFI). When a single flash is accompanied by 2 or more beeps, it is perceived as multiple flashes (fission illusion); conversely, a fusion illusion is experienced when more flashes are matched with a single beep, leading to the perception of a single flash. Such illusory perceptions are associated to crossmodal changes in visual cortical excitability. Indeed, increasing occipital cortical excitability, by means of transcranial electrical currents, disrupts the SIFI (ie, fission illusion)...
January 3, 2020: Journal of Pain
Alexandria Brunkow, Margeaux Cannon, Fiona S Graff, Jessica L Martin, Leslie R M Hausmann, Lisa M McAndrew
The opioid crisis has highlighted the importance of improving patients' access to behavioral treatments for chronic pain and addiction. What is not known is if patients are interested in receiving these treatments. In this cross-sectional study, over 1,000 participants with chronic pain were surveyed using an anonymous online questionnaire on Amazon Mechanical Turk to investigate participants' use of and interest in pharmacological and behavioral treatments for chronic pain and addiction. Participants also indicated whether their doctor had recommended these treatments...
January 3, 2020: Journal of Pain: Official Journal of the American Pain Society
Joshua R Zadro, Tom Ivar Lund Nilsen, Debra Shirley, Anita B Amorim, Paulo H Ferreira, Ragnhild Lier, Paul Jarle Mork
We investigated if parental multi-site chronic pain increases the risk of adult offspring developing additional chronic pain sites, and if offspring body mass index (BMI) and leisure time physical activity modify this association. We used longitudinal data on 7,654 offspring linked with their parents who participated in the population-based HUNT Study (Norway) in 1995-97 and 2006-08. Logistic regression was used to estimate odds ratios (ORs) with 95% confidence interval (CI). One-third of offspring (n=2,573) developed additional chronic pain sites...
January 2, 2020: Journal of Pain
Corey B Simon, Carolina Valencia, Rogelio A Coronado, Samuel S Wu, Zhigang Li, Yunfeng Dai, Kevin W Farmer, Michael M Moser, Thomas W Wright, Roger B Fillingim, Steven Z George
Shoulder surgery is a primary intervention for shoulder pain, yet many individuals experience persistent post-operative pain. Previously, we found individuals categorized as having a high-risk phenotype (comprised of COMT variation and pain catastrophizing) had approximately double the chance of not reaching a 12-month pain recovery criterion. As a means to better understand the development of persistent post-operative shoulder pain, this study advanced our previous work by examining temporal ordering of post-operative shoulder recovery based on potential mediating factors, and expansion of outcomes to include movement-evoked pain and shoulder active range of motion...
December 28, 2019: Journal of Pain: Official Journal of the American Pain Society
Rachel A Elphinston, Simone Scotti Requena, Daniel Angus, Dominique de Andrade, Christopher R Freeman, Melissa A Day
Codeine is one of the most common opioid medicines for treating pain. Australia introduced policy changes in February 2018 to up-schedule codeine to prescription-only medicine due to concerns of adverse effects, opioid dependency and overdose-related mortality. This study investigated the frequency and content of messages promoted on Twitter by four Australian peak pain organizations, pre- and post-policy implementation. A time series analysis examined frequency of Twitter posts over a 48-week period. Text analysis via Leximancer examined message content...
December 16, 2019: Journal of Pain
Debbie Ehrmann Feldman, Lisa C Carlesso, Richard L Nahin
The purpose of the study was to explore clinical management for new cases of musculoskeletal pain that are likely chronic. We used data from the National Ambulatory Medical Care Survey, 2007-2015, identifying visits with a new chronic musculoskeletal pain condition using predetermined ICD-9 codes. We documented prescribing of nonopioid pain medication, opioids, physical therapy (PT), counseling, and other nonpharmacologic treatments and explored associations between patient and provider factors for each of these treatments...
December 16, 2019: Journal of Pain: Official Journal of the American Pain Society
Andrea Polli, Lode Godderis, Manosij Ghosh, Kelly Ickmans, Jo Nijs
Accumulating evidence suggests that epigenetic mechanisms may hold great potential in the field of pain. We systematically reviewed the literature exploring epigenetic mechanisms in people with pain. Four databases have been interrogated: MEDLINE, The Cochrane Central Register of Controlled Trial, Scopus, and Web of Science, following PRISMA guidelines in conducting study selection and assessment. Thirty-seven studies were included. Studies explored epigenetics in conditions such as fibromyalgia, CRPS, neuropathies, or osteoarthritis...
December 16, 2019: Journal of Pain: Official Journal of the American Pain Society
Jennifer S Gewandter, Robert H Dworkin, Dennis C Turk, Eric G Devine, David Hewitt, Mark P Jensen, Nathaniel P Katz, Amy A Kirkwood, Richard Malamut, John D Markman, Bernard Vrijens, Laurie Burke, James N Campbell, Daniel B Carr, Philip G Conaghan, Penney Cowan, Mittie K Doyle, Robert R Edwards, Scott R Evans, John T Farrar, Roy Freeman, Ian Gilron, Dean Juge, Robert D Kerns, Ernest A Kopecky, Michael P McDermott, Gwendolyn Niebler, Kushang V Patel, Richard Rauck, Andrew S C Rice, Michael Rowbotham, Nelson E Sessler, Lee S Simon, Neil Singla, Vladimir Skljarevski, Tina Tockarshewsky, Geertrui F Vanhove, Ajay D Wasan, James Witter
The estimated probability of progressing from phase 3 analgesic clinical trials to regulatory approval is approximately 57%, suggesting that a considerable number of treatments with phase 2 trial results deemed sufficiently successful to progress to phase 3 do not yield positive phase 3 results. Deficiencies in the quality of clinical trial conduct could account for some of this failure. An Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) meeting was convened to identify potential areas for improvement in trial conduct in order to improve assay sensitivity (i...
December 13, 2019: Journal of Pain: Official Journal of the American Pain Society
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