Journal of Pain

Dolors Soler, David Moriña, Hatice Kumru, Joan Vidal, Xavier Navarro
Treatment of neuropathic pain (NP) in patients with spinal cord injury (SCI) remains a major challenge. The aim of the present study is to investigate if the effect of transcranial direct current stimulation (tDCS) combined with visual illusion (VI), following a previously published protocol, has differential effects on pain-related sensory symptoms according to sensory phenotypes profiles. One hundred and thirty SCI patients with NP participated in this open-label trial. Sixty-five patients were given a daily 20-minutes combined treatment of tDCS and VI for 2 weeks...
July 3, 2020: Journal of Pain
Andrea K Newman, Calia A Morais, Benjamin P Van Dyke, Beverly E Thorn
The examination of pain beliefs for chronic pain assessment and treatment has been a growing area of interest. A variety of questionnaires have been developed to assess pain beliefs, however, these questionnaires often require high levels of literacy and education. The Pain Concepts Questionnaire (PCQ) was developed with literacy-adaptations to better evaluate pain beliefs in a low socioeconomic (SES) population. This study is an initial exploratory evaluation of the PCQ in a sample of patients with chronic pain and multiple disparities as part of the Learning About My Pain (LAMP) trial, a randomized controlled trial comparing literacy-adapted psychosocial treatments for chronic pain...
June 27, 2020: Journal of Pain: Official Journal of the American Pain Society
C Thornton, D Sheffield, A Baird
During pain, motor performance tends to decline. However, athletes who engage in contact sports are able to maintain performance despite the inherent pain that accompanies participation. This may be the result of being challenged rather than threatened by pain; adaptive coping strategies; habituation to pain; or finding pain less bothersome. This study aimed to measure performance of a novel motor task both in pain and not in pain within experienced contact athletes (n = 40), novice contact athletes (n = 40) and non-contact athletes (n = 40)...
June 26, 2020: Journal of Pain
Yurun Cai, Suzanne G Leveille, Jeffrey M Hausdorff, Jonathan F Bean, Brad Manor, Robert R McLean, Tongjian You
This cross-sectional study examines the association between chronic musculoskeletal pain and foot reaction time (RT) among older community-living adults. Participants were 307 adults aged 71 years and older in the MOBILIZE Boston Study II. Pain severity, interference, and location were measured by the Brief Pain Inventory and a joint pain questionnaire. With participants seated, simple foot reaction time (SRT) was measured as self-selected foot response time to an intermittent light, and choice foot reaction time (CRT) was measured as response time to the light on the corresponding side of the sensored gait mat...
June 26, 2020: Journal of Pain
Michael A Wewege, Matthew D Jones
Exercise-induced hypoalgesia (EIH) is a reduction in pain that occurs during or following exercise. Randomised controlled studies published from 1980 to January 2020 that examined experimentally induced pain before and during/following a single bout of exercise in healthy individuals or people with chronic musculoskeletal pain were systematically reviewed. Data were analysed using random-effects meta-analyses and studies were appraised using the Cochrane Risk of Bias tool and GRADE. 5829 records were screened, with 13 studies ultimately included...
June 26, 2020: Journal of Pain: Official Journal of the American Pain Society
Verina Hanna, Helen Senderovich
Adequate analgesia can be challenging, as pharmacological options are not necessarily effective for all types of pain and are associated with adverse effects. Methadone is increasingly being considered in the management of both cancer-related and non-cancer-related pain. The purpose of this article is to provide a narrative review of all available randomized controlled trials (RCT) investigating the effectiveness of methadone in the management of pain, in relation to a comparison drug. The primary outcome was analgesic effectiveness, and the secondary outcomes were side effects and cost...
June 26, 2020: Journal of Pain: Official Journal of the American Pain Society
James A Watson, Cormac G Ryan, Greg Atkinson, Philip Williamson, Dominic Ellington, Robbie Whittle, John Dixon, Denis J Martin
Pain neuroscience education (PNE) is an approach used in the management of chronic musculoskeletal pain (CMP). Previous reviews on PNE and other pain interventions, have focussed on mean treatment effects, but in the context of "precision medicine", any inter-individual differences in treatment response are also important to quantify. If inter-individual differences are present, and predictors identified, PNE could be tailored to certain people for optimising effectiveness. Such heterogeneity can be quantified using recently-formulated approaches for comparing the response variance between the treatment and control groups...
June 22, 2020: Journal of Pain: Official Journal of the American Pain Society
Lianne Wood, Nadine E Foster, Martyn Lewis, Annette Bishop
Exercise is a core treatment for persistent non-specific low back pain (NSLBP), but results from randomised controlled trials (RCTs) of exercise typically show only small to moderate standardised mean differences (SMDs) compared to non-exercise controls. The choice of primary outcome, and relationship to the specific targets of exercise may influence this. This systematic review aimed to explore whether primary outcomes match the exercise treatment targets used in NSLBP RCTs and the potential impact of matching on SMDs...
June 21, 2020: Journal of Pain: Official Journal of the American Pain Society
Constance A Mara, Susmita Kashikar-Zuck, Natoshia Cunningham, Kenneth R Goldschneider, Bin Huang, Carlton Dampier, David D Sherry, Lori Crosby, Jennifer Farrell Miller, Kimberly Barnett, Esi M Morgan
The goal of the current study was to enhance the measurement of the pediatric chronic pain experience through a methodologically rigorous approach. This paper outlines the development and initial validation of a pain intensity measure for pediatric patients with chronic pain using PROMIS® methodology. Measure development incorporated feedback from children with painful conditions. Based on input from pediatric participants and content experts, four candidate items assessing pain intensity were included for large scale testing...
June 21, 2020: Journal of Pain
Yanfei Xie, Deokhoon Jun, Lucy Thomas, Brooke Coombes, Venerina Johnston
This systematic review and meta-analysis examined the evidence for altered central pain processing in people with non-traumatic neck pain and the relationship between central pain processing, demographics and pain-related characteristics. Case-control studies reporting measures of altered central pain processing using quantitative sensory testing were reviewed. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) between people with non-traumatic neck pain and controls were calculated. Meta-analysis was performed using random-effects models when appropriate...
June 20, 2020: Journal of Pain: Official Journal of the American Pain Society
Ewan McNicol, McKenzie Ferguson, Kathleen Bungay, Emily L Rowe, Sam Eldabe, Jennifer S Gewandter, Salim M Hayek, Nathaniel Katz, Brian H Kopell, John Markman, Ali Rezai, Rod S Taylor, Dennis C Turk, Robert H Dworkin, Richard B North, Simon Thomson
This systematic review assessed design characteristics and reporting quality of published randomized clinical trials of spinal cord stimulation (SCS) for treatment of pain in adults and adolescents. The study protocol was registered with PROSPERO (CRD42018090412). Relevant articles were identified by searching the following databases through December 31, 2018: MEDLINE, Embase, WikiStim, The Cochrane Database of Systematic Reviews, and The Cochrane Central Register of Controlled Trials. Forty-six studies were included...
June 20, 2020: Journal of Pain: Official Journal of the American Pain Society
Mikkel Thøgersen, Jamila Andoh, Christopher Milde, Thomas Graven-Nielsen, Herta Flor, Laura Petrini
Phantom limb pain (PLP) may be relieved using a visual representation of an intact limb. However, patients with distorted (telescoped) phantoms seem unable to associate with visualizations of intact limbs. A virtual arm visualization was matched to the individual's phantom perception and controlled in an augmented reality (AR) intervention. Seven PLP participants with telescoped phantoms performed eight supervised home-based AR-training sessions (45 min each) within two weeks. The virtual arm was superimposed in AR onto their residual limb and controlled using electromyography from the residual limb...
June 20, 2020: Journal of Pain
Ruichen Shu, Linlin Zhang, Hao Zhang, Yuan Li, Chunyan Wang, Lin Su, Hongwei Zhao, Guolin Wang
N-methyl-D-aspartate (NMDA) receptor activation is known to be critical in remifentanil-induced hyperalgesia. Evidence indicates that iron accumulation participates in NMDA neurotoxicity. This study aims to investigate the role of iron accumulation in remifentanil-induced hyperalgesia. Remifentanil was delivered intravenously in rats to induce hyperalgesia. The NMDA receptor antagonist MK-801 was intrathecally administrated. The levels of divalent metal transporter 1 without iron-responsive element [DMT1(-)IRE] and iron were detected...
June 20, 2020: Journal of Pain: Official Journal of the American Pain Society
Anna Zajacova, Richard G Rogers, Eric Grodsky, Hanna Grol-Prokopczyk
Pain is a major health problem among US adults. Surprisingly little, however, is known about educational disparities in pain, especially among the nonelderly. In this study, we analyze disparities in pain across levels of educational attainment. Using data from the 2010-2017 National Health Interview Survey among adults aged 30-49 (N=74,051), we estimate logistic regression models of pain prevalence using a dichotomous summary pain index and its five constituent pain sites (low back, joint, neck, headache/migraine, and facial/jaw)...
June 20, 2020: Journal of Pain: Official Journal of the American Pain Society
Mark S Wallace, Thomas D Marcotte, J H Atkinson, Hayley Treloar Padovano, Marcel Bonn-Miller
This report examines the association between THC plasma levels and pain response in a secondary analysis of data from a recent diabetic neuropathy study that demonstrated a dose-dependent reduction in spontaneous and elicited pain at specific time points. A randomized, double-blinded, placebo-controlled crossover study was conducted in sixteen patients with painful diabetic peripheral neuropathy (PDN). Subjects participated in four sessions, separated by 2 weeks, during each of which they were exposed to one of four conditions: placebo, or 1%, 4% or 7% THC dose of cannabis...
June 18, 2020: Journal of Pain
Meghan A Rossi, Jessica A Maxwell, Natalie O Rosen
Postpartum pain during intercourse is a prevalent and distressing problem that has substantial consequences for affected couples. Partner perceptions-such as how partners perceive women's pain self-efficacy-contribute to an individual's pain experience. This study examined whether partners under- or over-estimate women's intercourse pain self-efficacy at 3-months postpartum and the implications of this bias for women's pain and couples' sexual functioning at 3- and 6-months postpartum. Women who reported pain during intercourse and their partners (N = 89 couples) completed online measures assessing pain self-efficacy (own or partner perceptions), pain intensity, and sexual functioning at 3- and 6-months postpartum...
June 16, 2020: Journal of Pain
Sami Abu Hamdeh, Payam Emami Khoonsari, Ganna Shevchenko, Torsten Gordh, Hans Ericson, Kim Kultima
The main cause of trigeminal neuralgia (TN) is compression of a blood vessel at the root entry zone of the trigeminal nerve. However, a neurovascular conflict does not seem to be the only etiology and other mechanisms are implicated in the development of the disease. We hypothesized that TN patients may have distinct protein expression in the CSF. In this study, lumbar CSF from TN patients (n=17), scheduled to undergo microvascular decompression (MVD), and from controls (n=20) was analyzed and compared with mass spectrometry-based shotgun proteomics...
June 14, 2020: Journal of Pain: Official Journal of the American Pain Society
Rena Gatzounis, Ann Meulders
In exposure for chronic pain, avoidance is often forbidden (extinction with response prevention; RPE) to prevent misattributions of safety. Although exposure is an effective treatment, relapse is common. Little is known about the underlying mechanisms of return of pain-related avoidance. We hypothesized that pain-related avoidance would recover when becoming available again after RPE and after unexpected pain episodes ("reinstatement"), especially when restricting avoidance during RPE (compared to instructing not to use it)...
June 14, 2020: Journal of Pain
Jennifer A Rabbitts, Tonya M Palermo, Chuan Zhou, Alagumeena Meyyappan, Lucas Chen
Acute and chronic pain delay recovery and impair outcomes after major pediatric surgery. Understanding unique risk factors for acute and chronic pain is critical to developing effective treatments for youth at risk. We aimed to identify adolescent and family psychosocial predictors of acute and chronic postsurgical pain following major surgery in adolescents. Participants included 119 youth age 10-18 years (Mage =14.9;78.2% white) undergoing major musculoskeletal surgery and their parents. Participants completed pre-surgery baseline questionnaires, with youth reporting on baseline pain, anxiety, depression, insomnia and sleep quality, and parents reporting on parental catastrophizing and family functioning...
June 14, 2020: Journal of Pain
Helene M Langevin
A challenge in understanding chronic musculoskeletal pain is that research is often siloed between neuroscience, physical therapy/rehabilitation, orthopedics and rheumatology which focus respectively on 1) neurally-mediated effects on pain processes, 2) behavior and muscle activity, 3) tissue structure and 4) inflammatory processes. Although these disciplines individually study important aspects of pain, there is a need for more cross-disciplinary research that can bridge between them. Identifying the gaps in knowledge is important to understand the whole body, especially at the interfaces between the silos-between brain function and behavior, between behavior and tissue structure, between musculoskeletal and immune systems, and between peripheral tissues and the nervous system...
June 14, 2020: Journal of Pain
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