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Journal of Pain: Official Journal of the American Pain Society

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https://read.qxmd.com/read/30853506/are-signs-of-central-sensitisation-in-acute-low-back-pain-a-precursor-to-poor-outcome
#1
David M Klyne, G Lorimer Moseley, Michele Sterling, Mary F Barbe, Paul W Hodges
Central sensitisation is considered to have a pathophysiological role in chronic low back pain (LBP). Whether individuals with increased central sensitisation early in their condition are more likely to develop persistent pain or whether it increases over time is unclear. This study aimed to determine whether sensory profiles during acute LBP differ between individuals who did and did not recover by 6-months and to identify subgroups associated with outcomes. Individuals with acute LBP (<2 weeks of onset, N=99) underwent pain threshold (heat/cold/pressure) and conditioned pain modulation (CPM) testing after completing questionnaires related to pain/disability, sleep, and psychological status...
March 7, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30853505/lack-of-antinociceptive-cross-tolerance-with-co-administration-of-morphine-and-fentanyl-into-the-periaqueductal-gray-of-male-sprague-dawley-rats
#2
Erin N Bobeck, Shauna M Schoo, Susan L Ingram, Michael M Morgan
Tolerance to the antinociceptive effect of mu-opioid receptor (MOPr) agonists, such as morphine and fentanyl, greatly limits their effectiveness for long-term use to treat pain. Clinical studies have shown that combination therapy and opioid rotation can be used to enhance opioid-induced antinociception once tolerance has developed. The mechanism and brain regions involved in these processes are unknown. The purpose of this study was to evaluate the contribution of the ventrolateral periaqueductal gray (vlPAG) to antinociceptive tolerance and cross-tolerance between administration and co-administration of morphine and fentanyl...
March 7, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30844507/perioperative-pregabalin-and-intraoperative-lidocaine-infusion-to-reduce-persistent-neuropathic-pain-after-breast-cancer-surgery-a-multicenter-factorial-randomized-controlled-pilot-trial
#3
James S Khan, Nicole Hodgson, Stephen Choi, Susan Reid, James E Paul, Nicole J Look Hong, Claire Holloway, Jason W Busse, Ian Gilron, D Norman Buckley, Michael McGillion, Hance Clarke, Joel Katz, Sean Mackey, Ronen Avram, Kayla Pohl, Purnima Rao-Melacini, P J Devereaux
Persistent post-surgical pain is defined as pain localized to the area of surgery of at least 2-month duration and is unfortunately a common complication after breast cancer surgery. While there is insufficient evidence to support any preventative strategy, prior literature suggests possible efficacy of intravenous lidocaine and perioperative pregabalin in preventing persistent pain after surgery. To determine feasibility of conducting a larger definitive trial, we conducted a multicenter 2-by-2 factorial randomized placebo-controlled pilot trial of 100 female patients undergoing breast cancer surgery...
March 4, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30831273/pain-neuroscience-education-for-adults-with-chronic-musculoskeletal-pain-a-mixed-methods-systematic-review-and-meta-analysis
#4
REVIEW
James A Watson, Cormac G Ryan, Lesley Cooper, Dominic Ellington, Robbie Whittle, Michael Lavender, John Dixon, Greg Atkinson, Kay Cooper, Denis J Martin
Chronic musculoskeletal pain (CMP) is an urgent global public health concern. Pain neuroscience education (PNE) is an intervention used in the management of CMP aiming to reconceptualise an individual's understanding of their pain as less threatening. This mixed-methods review undertook a segregated synthesis of quantitative and qualitative studies to investigate the clinical effectiveness, and patients' experience of, PNE for people with CMP. Electronic databases were searched for studies published between 01/01/2002 and 14/06/2018...
March 1, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30825639/conditioned-pain-modulation-in-sexual-assault-survivors
#5
Natalie Hellman, Cassandra A Sturycz, Edward W Lannon, Bethany L Kuhn, Yvette M Güereca, Tyler A Toledo, Michael F Payne, Felicitas A Huber, Mara Demuth, Shreela Palit, Joanna O Shadlow, Jamie L Rhudy
Sexual assault (SA) is associated with increased risk for chronic pain, but the mechanisms for this relationship are poorly understood. To explore whether disrupted descending inhibition is involved, this study used a conditioned pain modulation (CPM) task to study inhibition of pain and the nociceptive flexion reflex (NFR; a correlate of spinal nociception) in 32 pain-free SA survivors. This group was compared to 32 pain-free, trauma-exposed persons without SA (no-SA group) and a group of 40 pain-free persons who reported no trauma exposure (no-TE)...
February 27, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30822536/response-to-wolfe-letter-to-the-editor-fibromyalgia-criteria
#6
LETTER
Lesley M Arnold, Robert M Bennett, Leslie J Crofford, Linda E Dean, Daniel J Clauw, Don L Goldenberg, Mary-Ann Fitzcharles, Eduardo S Paiva, Roland Staud, Piercarlo Sarzi-Puttini, Dan Buskila, Gary J Macfarlane
No abstract text is available yet for this article.
February 26, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30822535/how-an-understanding-of-our-ability-to-adhere-to-verbal-rules-can-increase-insight-into-mal-adaptive-functioning-in-chronic-pain
#7
Melanie Beeckman, Sean Hughes, Ama Kissi, Laura E Simons, Liesbet Goubert
Research on chronic pain has traditionally focused on how direct pain experiences lead to maladaptive thoughts, feelings, and actions which set the stage for, and maintain, pain-related disability. Yet the capacity for language (and more specifically verbal instructions or rules) to put people into indirect contact with pain has never been systematically investigated. In this paper we introduce a novel theoretical perspective on verbal processes and discuss how the study of verbal rules may increase our understanding of both maladaptive and adaptive functioning in chronic pain...
February 26, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30802544/activation-of-sphingosine-1-phosphate-receptor-1-in-the-spinal-cord-produces-mechano-hypersensitivity-through-the-activation-of-inflammasome-and-il-1%C3%AE-pathway
#8
Timothy M Doyle, Zhoumou Chen, Mariaconcetta Durante, Daniela Salvemini
Sphingosine-1-phosphate (S1P) receptor 1 subtype (S1PR1) activation by its ligand S1P in the dorsal horn of the spinal cord (DH-SC) causes mechano-hypersensitivity. The cellular and molecular pathways remain poorly understood. We now report that activation of S1PR1 with intrathecal injection of the highly selective S1PR1 agonist SEW2871 led to the development of mechano-allodynia by activating the nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome (increased expression of NLRP3, cleaved caspase 1 and mature interleukin (IL)-1β) in the DH-SC...
February 22, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30797963/sensory-affective-and-catastrophizing-reactions-to-multiple-stimulus-modalities-results-from-the-oklahoma-study-of-native-american-pain-risk-ok-snap
#9
Jamie L Rhudy, Edward W Lannon, Bethany L Kuhn, Shreela Palit, Michael F Payne, Cassandra A Sturycz, Natalie Hellman, Yvette M Güereca, Tyler A Toledo, Heather B Coleman, Kathryn A Thompson, Jessica M Fisher, Samuel P Herbig, Ky'Lee B Barnoski, Lucinda Chee, Joanna O Shadlow
Native Americans (NAs) have a higher prevalence of chronic pain than any other U.S. racial/ethnic group; however, little is known about the mechanisms for this pain disparity. This study used quantitative sensory testing (QST) to assess pain experience in healthy, pain-free adults (N=137 NAs [87 female], N=145 non-Hispanic whites [NHW; 68 female]) following painful electric, heat, cold, ischemic, and pressure stimuli. Following each stimulus, ratings of pain intensity, sensory pain, affective pain, pain-related anxiety, and situation-specific pain catastrophizing were assessed...
February 21, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30797962/the-role-of-perceived-stress-and-life-stressors-in-the-development-of-chronic-musculoskeletal-pain-disorders-a-systematic-review
#10
REVIEW
Valentina Buscemi, Wei-Ju Chang, Matthew B Liston, James H McAuley, Siobhan M Schabrun
The aetiological role of work-related psychological stress in the development of musculoskeletal pain disorders (MDs) has been systematically investigated. Less clear however, is the role of perceived stress and life stressors. This review aimed to assess the evidence for an aetiological role of perceived stress and life stressors in the development of chronic MDs. Database searches were conducted to identify prospective longitudinal studies that assessed perceived stress and life stressors in individuals without, or in the first 6 weeks of musculoskeletal pain...
February 21, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30776495/race-ethnicity-does-not-moderate-the-relationship-between-adverse-life-experiences-and-temporal-summation-of-the-nociceptive-flexion-reflex-and-pain-results-from-the-oklahoma-study-of-native-american-pain-risk-ok-snap
#11
Cassandra A Sturycz, Natalie Hellman, Michael F Payne, Bethany L Kuhn, Burkhart Hahn, Edward W Lannon, Shreela Palit, Yvette M Güereca, Tyler A Toledo, Joanna O Shadlow, Jamie L Rhudy
Adverse life experiences (ALEs) are associated with hyperalgesia and chronic pain, but the underlying mechanisms are poorly understood. One potential mechanism is hyperexcitability of spinal neurons (i.e., central sensitization). Given that Native Americans (NA) are more likely to have ALEs, and have a higher prevalence of chronic pain, the relationship between ALEs and spinal hyperexcitability might contribute to their pain risk. The present study assessed temporal summation of the nociceptive flexion reflex (TS-NFR; correlate of spinal hyperexcitability) and pain (TS-Pain) in 246 healthy, pain-free non-Hispanic whites (NHW) and Native Americans (NA)...
February 15, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30771593/systematic-review-and-neural-network-analysis-to-define-predictive-variables-in-implantable-motor-cortex-stimulation-to-treat-chronic-intractable-pain
#12
REVIEW
D J H A Henssen, R L Witkam, J C M L Dao, D J Comes, A M Van Cappellen van Walsum, T Kozicz, Robert van Dongen, K Vissers, R H M A Bartels, G de Jong, E Kurt
Implantable Motor Cortex Stimulation (iMCS) has been performed for over 25 years to treat various intractable pain syndromes. Its effectiveness shows to be highly variable and although various studies revealed predictive variables, none of these were found repeatedly. This study uses neural network analysis (NNA) to identify predictive factors of iMCS treatment of intractable pain. A systematic review provided a database of patient data on an individual level of patients who underwent iMCS to treat refractory pain between 1991 and 2017...
February 13, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30771592/somatic-symptoms-in-pediatric-patients-with-chronic-pain-proposed-clinical-reference-points-for-the-children-s-somatic-symptoms-inventory-formerly-children-s-somatization-inventory
#13
Amanda L Stone, Lynn S Walker, Lauren C Heathcote, J Maya Hernandez, Molly C Basch, Anna C Wilson, Laura E Simons
Among youth with chroic pain, elevated somatic symptoms across multiple body systems have been associated with greater emotional distress and functional disability and could represent poor adaptation to pain. The Children's Somatic Symptoms Inventory (formerly the Children's Somatization Inventory) is commonly used to assess somatic symptoms in children. However, no studies have evaluated the clinical utility of the measure in the assessment of pediatric patients with chronic pain. This study evaluated the factor structure and clinical relevance of the 24-item Children's Somatic Symptoms Inventory (CSSI-24) in youth (n = 1150) with mixed chronic pain complaints presenting to a tertiary pain clinic...
February 13, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30765303/letter-to-the-editor-fibromyalgia-criteria
#14
LETTER
Frederick Wolfe
No abstract text is available yet for this article.
February 11, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30742914/imbalance-between-excitatory-and-inhibitory-synaptic-transmission-in-the-primary-somatosensory-cortex-caused-by-persistent-nociception-in-rats
#15
Fa-Le Cao, Min Xu, Kerui Gong, Yan Wang, Ruirui Wang, Xuefeng Chen, Jun Chen
There is substantial evidence supporting the notion that the primary somatosensory (S1) cortex is an important structure involved in the perceptional component of pain. However, investigations have mainly focused on other pain-related formations, and few reports have been provided to investigate the synaptic plasticity in the S1 cortex in response to persistent pain. In the present study, we report that bee venom (BV) injection triggered an imbalance between excitatory and inhibitory synaptic transmission in the S1 cortex in rats...
February 8, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30735731/pain-relief-as-a-motivation-for-cannabis-use-among-young-adult-users-with-and-without-chronic-pain
#16
Jessica L Fales, Benjamin O Ladd, Renee E Magnan
No abstract text is available yet for this article.
February 5, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30716471/congenital-insensitivity-to-pain-a-misnomer
#17
Asaf Weisman, John Quintner, Youssef Masharawi
"Congenital insensitivity to pain (CIP)" is an umbrella term used to describe a group of rare genetic diseases also classified as "Hereditary Sensory Autonomic Neuropathies (HSAN)". These are intriguing conditions with potential to shed light on the poorly understood relationship concerning nociception and the experience of pain. However, the term CIP is epistemologically incorrect and is the product of historical circumstances. The term conflates pain and nociception and thus prevents researchers and caregivers from grasping the full dimensions of these conditions...
February 1, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30710707/differences-in-neuronal-representation-of-mental-rotation-in-crps-patients-and-healthy-controls
#18
M Kohler, S Strauss, U Horn, I Langner, T Usichenko, N Neumann, M Lotze
Spatial integration of parts of the body is impaired in patients with complex regional pain syndrome (CRPS). Since the training of mental rotation (MR) has been shown to be among the effective therapy strategies for CRPS, impairment of MR is also important for the pathophysiological understanding of CRPS. The aim of this study was to evaluate whether differences in neural representation of MR occur between CRPS patients and healthy controls. Therefore we included 15 chronic CRPS patients and 15 age-/gender matched healthy controls...
January 30, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30707953/blockade-of-nmda-receptors-and-nitric-oxide-synthesis-potentiated-morphine-induced-anti-allodynia-via-attenuating-pain-related-amygdala-pcreb-creb-signaling-pathway
#19
Bahardokht Tolou-Dabbaghian, Ladan Delphi, Ameneh Rezayof
The present study investigated the role of the amygdala NMDA receptors/NOS pathway in morphine-induced anti-allodynia. Concurrently with the bilateral cannulation of the central amygdala (CeA), chronic constriction of the sciatic nerve was performed on male Wistar rats. Morphine (3-5 mg/kg) was intraperitoneally administered to induce anti-allodynia. When D-AP5, a selective NMDA receptor antagonist, (0.05-0.1 µg/rat) or L-NAME, the NO synthase inhibitor, (0.1-0.5 µg/rat) were microinjected into the CeA, the higher doses potentiated an ineffective dose of morphine (3 mg/kg)...
January 29, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30690169/pills-to-pot-observational-analyses-of-cannabis-substitution-among-medical-cannabis-users-with-chronic-pain
#20
Kevin F Boehnke, J Ryan Scott, Evangelos Litinas, Suzanne Sisley, David A Williams, Daniel J Clauw
Chronic pain is common, costly and challenging to treat. Many individuals with chronic pain have turned to cannabis as an alternative form of pain management. We report results from an ongoing, online survey of medical cannabis users with chronic pain nationwide about how cannabis affects pain management, health, and pain medication use. We also examined whether and how these parameters were affected by concomitant recreational use, and duration of use (novice: <1 year vs. experienced: ≥1 year). 1,321 participants (59% female, 54% ≥50 years old) completed the survey...
January 25, 2019: Journal of Pain: Official Journal of the American Pain Society
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