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Journal of Pain

Hana Starobova, Alexander Mueller, Jennifer R Deuis, David A Carter, Irina Vetter
Vincristine, oxaliplatin, and cisplatin are commonly prescribed chemotherapeutic agents for the treatment of many tumors. However, a main side-effect is chemotherapy-induced peripheral neuropathy (CIPN), which may lead to changes in chemotherapeutic treatment. Although symptoms associated with CIPN are recapitulated by mouse models, there is limited knowledge of how these drugs affect the expression of genes in sensory neurons. The present study carried out a transcriptomic analysis of dorsal root ganglia (DRG) following vincristine, oxaliplatin, and cisplatin treatment with a view to gain insight into the comparative pathophysiological mechanisms of CIPN...
June 28, 2019: Journal of Pain: Official Journal of the American Pain Society
Jonas Zaman, Katja Wiech, Johan W S Vlaeyen
Pain intensity ratings are subject to various cognitive modulations - yet the mechanisms underlying this influence are still not understood. In a conditioning protocol, pain-related expectations were induced through pairing predefined movements with a noxious or innocuous stimulus in either a predictable or unpredictable fashion. Healthy volunteers (N = 37) categorized the stimuli as either painful or non-painful and rated their perceived intensity. Using a Hierarchical Drift Diffusion model based on the categorization data, we found that an a priori decision-making bias evolved towards the expected sensations (p < ...
June 28, 2019: Journal of Pain: Official Journal of the American Pain Society
Stijn Schouppe, Sophie Van Oosterwijck, Lieven Danneels, Stefaan Van Damme, Jessica Van Oosterwijck
This systematic review analyzed available literature on functional brain alterations in low back pain (LBP) measured with electroencephalography (EEG), as until now evidence thereof was unclear. Four electronic databases were systematically searched the 10th of March 2018, resulting in 12 included studies. Studies showed a risk of bias of 37.5%-75% using the Newcastle-Ottawa Scale for case-control studies. Limited evidence reported higher amplitudes of balance-related potentials and early components of somatosensory evoked potentials (SEP) to noxious stimuli, and altered feedback-related negativity and P300 potentials during decision-making in chronic LBP (CLBP)...
June 28, 2019: Journal of Pain: Official Journal of the American Pain Society
Susan T Tran, Marissa L Koven, Ashley S Castro, Ana B Goya Arce, Jocelyn S Carter
Research in adult populations indicates that several sociodemographic and environmental variables increase risk for pain and poor outcomes. There is little research exploring the impact of household income, health insurance coverage, barriers to health care, neighborhood and school safety, violence experienced, and neighborhood isolation on pediatric chronic pain. Data from the Add Health Study, a longitudinal examination of a nationally-representative adolescent sample were analyzed. The relationships between demographic variables, risk factors, chronic pain, and long-term health outcomes were examined...
June 27, 2019: Journal of Pain: Official Journal of the American Pain Society
Melissa A Day, Beverly E Thorn, Dawn M Ehde, John W Burns, Amanda Barnier, Jason B Mattingley, Natasha Mathews, Mark P Jensen
This study examined psychosocial pain treatment moderation in a secondary analysis of a trial that compared cognitive therapy (CT), mindfulness-meditation (MM), and mindfulness-based cognitive therapy (MBCT) for chronic low back pain (CLBP). The Limit, Activate and Enhance (LA&E) model of moderation provided a framework for testing a priori hypotheses. Adult participants (N=69) with CLBP completed a pre-treatment assessment of hypothesized moderators: pain catastrophizing, brain state as assessed by electroencephalogram, mindful observing, and non-reactivity...
June 25, 2019: Journal of Pain: Official Journal of the American Pain Society
Natasha M Sosanya, Raina Kumar, John L Clifford, Roger Chavez, George Dimitrov, Seshamalini Srinivasan, Aarti Gautam, Alex V Trevino, Molly Williams, Rasha Hammamieh, Bopaiah P Cheppudira, Robert J Christy, Stephen L Crimmins
Research into potentially novel biomarkers for chronic pain development is lacking. microRNAs (miRNAs) are attractive candidates as biomarkers due to their conservation across species, stability in liquid biopsies, and variation that corresponds to a pathologic state. miRNAs can be sorted into extracellular vesicles (EVs) within the cell and released from the site of injury. EVs transfer cargo molecules between cells thus affecting key intercellular signaling pathways. The focus of this study was to determine the plasma derived EV miRNA content in a chronic neuropathic pain rat model...
June 19, 2019: Journal of Pain: Official Journal of the American Pain Society
David A Seminowicz, Tribikram Thapa, Siobhan M Schabrun
Aberrant motor cortex plasticity is hypothesised to contribute to chronic musculoskeletal pain, but evidence is limited. Critically, studies have not considered individual differences in motor plasticity or how this relates to pain susceptibility. Here we examined the relationship between corticomotor excitability and an individual's susceptibility to pain as pain developed, was sustained and resolved over 21 days. Nerve growth factor was injected into the right extensor carpi radialis brevis muscle of 20 healthy individuals on day 0, 2 and 4...
June 12, 2019: Journal of Pain: Official Journal of the American Pain Society
Casey A Mussio, Steven E Harte, George S Borszcz
The anterior cingulate cortex (ACC) modulates emotional responses to pain. Whereas, the caudal ACC (cACC) promotes expression of pain affect, the rostral ACC (rACC) contributes to its suppression. Both subdivisions receive glutamatergic innervation, and the present study evaluated the contribution of NMDA receptors within these subdivisions to rats' expression of pain affect. Vocalizations that follow a brief noxious tail shock (vocalization afterdischarges, VAD) are a validated rodent model of pain affect...
June 12, 2019: Journal of Pain: Official Journal of the American Pain Society
Chung Jung Mun, Linda Ruehlman, Paul Karoly
The present study examined how multiple chronic pain conditions and pain sites are associated with socio-demographics, chronic pain adjustment profiles, and emotional distress. A total of 2407 individuals who reported at least six months of having consistent pain severity, pain interference, and/or emotional burden due to pain were recruited through random digit dialing across the United States. Participants' chronic pain adjustment profiles (i.e., pain intensity, pain interference, emotional burden, pain catastrophizing, pain coping, pain attitudes, and social resources) were assessed...
June 12, 2019: Journal of Pain: Official Journal of the American Pain Society
Wei Lei, Rakesh H Vekariya, Subramaniam Ananthan, John M Streicher
Numerous studies have demonstrated a physiological interaction between the mu opioid receptor (MOR) and delta opioid receptor (DOR) systems. A few studies have shown that dual MOR-DOR agonists could be beneficial, with reduced tolerance and addiction liability, but are nearly untested in chronic pain models, particularly neuropathic pain. In this study, we tested the MOR-DOR agonist SRI-22141 in mice in the clinically relevant models of HIV Neuropathy and Chemotherapy-Induced Peripheral Neuropathy (CIPN). SRI-22141 was more potent than morphine in the tail flick pain test, and had equal or enhanced efficacy vs...
June 12, 2019: Journal of Pain: Official Journal of the American Pain Society
Trevor A Lentz, Daniel I Rhon, Steven Z George
This study determined the predictive capabilities of pain intensity and disability on health care utilization (number of condition-specific health care visits, incident and chronic opioid use) and costs (total condition-specific and overall medical costs) in the year following an initial evaluation for musculoskeletal pain. We explored pain catastrophizing and spatial distribution of symptoms (i.e., body diagram symptom score) as mediators of these relationships. Two hundred eighty-three military service members receiving initial care for a musculoskeletal injury completed a region-specific disability measure, numeric pain rating scale, Pain Catastrophizing Scale (PCS) and body pain diagram...
June 12, 2019: Journal of Pain: Official Journal of the American Pain Society
Kelly L Huffman, Darcy Mandell, Jennier K Lehmann, Xavier Jimenez, Brittany R Lapin
Patients treated in interdisciplinary chronic pain rehabilitation programs (ICPRPs) show long-term improvements in symptoms, however outcomes may vary across heterogenous patient subpopulations. This longitudinal retrospective study characterizes the influence of opioids, mood, patient characteristics and baseline symptoms on pain and functional impairment (FI) in 1681 patients 6-months to 12-months post-treatment in an ICPRP incorporating opioid weaning. Linear mixed models showed immediate and durable treatment benefits with non-uniform worsening at follow up which slowed over time...
June 5, 2019: Journal of Pain: Official Journal of the American Pain Society
Dr Emma Godfrey, Dr Vari Wileman, Dr Melissa Galea Holmes, Professor Lance M McCracken, Dr Sam Norton, Professor Rona Moss-Morris, Ms Sandra Noonan, Dr Massimo Barcellona, Dr Duncan Critchley
Chronic low back pain (CLBP) is a major cause of global disability and improving management is essential. Acceptance and Commitment Therapy (ACT) is a promising treatment for chronic pain but has not been modified for physical therapy. This randomized controlled trial (RCT) compared physical therapy informed by Acceptance and Commitment Therapy (PACT) against standard care physical therapy for patients with CLBP. Patients with CLBP (duration ≥12 weeks, mean 3 years) were recruited from physical therapy clinics in four UK public hospitals...
June 4, 2019: Journal of Pain: Official Journal of the American Pain Society
Andrew Schrepf, Vy Phan, J Quentin Clemens, William Maixner, David Hanauer, David A Williams
Chronic Overlapping Pain Conditions (COPCs) are a set of painful chronic conditions characterized by high levels of co-occurrence. It has been hypothesized that COPCs co-occur in many cases because of common neurobiological vulnerabilities. In practice, most research on COPCs has focused upon a single index condition with little effort to assess comorbid painful conditions. This likely means that important phenotypic differences within a sample are obscured. The International Classification of Diseases (ICD) coding system contains many diagnostic classifications that may be applied to individual COPCs, but there is currently no agreed upon set of codes for identifying and studying each of the COPCs...
May 30, 2019: Journal of Pain: Official Journal of the American Pain Society
Jessica L Fales, Lexa K Murphy, Jason D Rights, Tonya M Palermo
This study aims to (1) examine the temporal influence of peer victimization on mood, sleep quality, pain, and activity limitations in clinical and community samples of youth, and (2) test mood and sleep as mediators of peer victimization-pain pathways. One hundred fifty-six adolescents (n=74 chronic pain group) completed a week of online diary monitoring assessing their daily peer victimization experiences, negative mood, sleep quality, pain intensity, and pain-related activity limitations. In multilevel models controlling for group status, person-mean peer victimization (averaged across days) significantly predicted worse mood, pain, and activity limitations (all ps < ...
May 29, 2019: Journal of Pain: Official Journal of the American Pain Society
Magdalena A Ferdek, Joukje M Oosterman, Agnieszka K Adamczyk, Mieke van Aken, K J Woudsma, B W M M Peeters, Annemiek Nap, Miroslaw Wyczesany, Clementina M van Rijn
Using EEG recordings of patients with endometriosis-related chronic pelvic pain, we have examined the effective connectivity within the cortical pain-related network during rest and during pain-related imagery. During rest, an altered connectivity was hypothesized between cortical somatosensory pain areas and regions involved in emotional and cognitive modulation of pain. During pain-related imagery, alterations in prefrontal-temporal connectivity were expected. The effective connectivity was estimated using the Directed Transfer Function method...
May 29, 2019: Journal of Pain
Biya Tang, Andrew Geers, Kirsten Barnes, Ben Colagiuri
Placebo analgesia is a robust phenomenon readily observed in both experimental and clinical settings. While researchers have begun to unpack its psychobiological mechanisms, important questions remain regarding how we can capitalize on the placebo effect to improve clinical pain outcomes. The current study tested whether providing individuals with instrumental control - i.e. control over if and when they administer a treatment - is capable of enhancing placebo analgesia. Using an established electro-cutaneous pain design, 87 healthy volunteers either received placebo conditioning with instrumental control over treatment administration, standard passive placebo conditioning without any control over treatment administration, or were allocated to natural history control group with no conditioning and were later tested at equivalent shock intensity with and without placebo applied...
May 28, 2019: Journal of Pain: Official Journal of the American Pain Society
Kevin F Boehnke, J Ryan Scott, Evangelos Litinas, Suzanne Sisley, Daniel J Clauw, Jenna Goesling, David A Williams
Cannabis is commonly used to manage chronic pain, but cannabis use patterns among individuals with chronic pain has not been well-characterized. We report cannabinoid, administration route, and product selection preferences among medical cannabis users with chronic pain from an ongoing, online survey. We also examined whether these preferences are affected by differences in sex, intentions behind use (medical only [MED] vs. medical + recreational [MEDREC]), and experience with cannabis (novice: <1 year vs...
May 24, 2019: Journal of Pain: Official Journal of the American Pain Society
Enrico De Martino, Ana Mércia Fernandes, Ricardo Galhardoni, Carolina De Oliveira Souza, Daniel Ciampi De Andrade, Thomas Graven-Nielsen
10Hz repetitive transcranial magnetic stimulation (10Hz-rTMS) to the left dorsolateral prefrontal cortex (L-DLPFC) produces analgesia, probably by activating the pain modulation system. A newer rTMS paradigm, called theta burst stimulation (TBS), has been developed. Unlike 10Hz-rTMS, prolonged continuous TBS (pcTBS) mimics endogenous theta rhythms, which can improve induction of synaptic long-term potentiation. Therefore, this study investigated whether pcTBS to the L-DLPFC reduced pain sensitivity more efficiently compared with 10Hz-rTMS, the analgesic effects lasted beyond the stimulation period, and the reduced pain sensitivity was associated with increased efficacy of conditioned pain modulation (CPM) and/or intra-cortical excitability...
May 24, 2019: Journal of Pain: Official Journal of the American Pain Society
Meghan Mayhew, Lynn L DeBar, Richard A Deyo, Robert D Kerns, Joseph L Goulet, Cynthia A Brandt, Michael Von Korff
Effective management of patients with pain requires accurate information about the prevalence, outcomes, and co-occurrence of common pain conditions. However, the transition from ICD-9-CM to ICD-10-CM diagnostic coding in 2015 left researchers without methods for comparing the prevalence of pain conditions before and after the transition. In this study, we developed and assessed a diagnostic framework to serve as a crosswalk between ICD-9-CM and ICD-10-CM diagnosis codes for common pain-related health conditions...
May 23, 2019: Journal of Pain: Official Journal of the American Pain Society
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