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JOURNAL ARTICLE
Buse Sarigul, Randy S Bell, Randall M Chesnut, Sergio Aguilera, Andras Buki, Giuseppe Citerio, D James Cooper, Ramon R Diaz-Arrastia, Michael Diringer, Anthony Figaji, Guoyi Gao, Romer Geocadin, Jamshid Ghajar, Odette A Harris, Alan Hoffer, Peter John Hutchinson, Matthew Joseph, Ryan Seiji Kitagawa, Geoffrey T Manley, Stephan Mayer, David Menon, Geert Meyfroidt, Daniel Michael, Mauro Oddo, David O Okonkwo, Mayur B Patel, Claudia S Robertson, Jeffrey V Rosenfeld, Andres M Rubiano, Juan Sahuquillo, Franco Servadei, Lori Shutter, Deborah Stein, Nino Stocchetti, Fabio Taccone, Shelly Timmons, Eve Tsai, Jamie S Ullman, Paul M Vespa, Walter Videtta, David Wright, Christopher Zammit, Gregory Hawryluk
Best practice guidelines have advanced severe traumatic brain injury (TBI) care, however, little currently informs goals of care decisions and processes despite their importance and frequency. Panelists from the Seattle International severe traumatic Brain Injury Consensus Conference (SIBICC) participated in a survey consisting of 24 questions. Questions queried use of prognostic calculators, variability in and responsibility for goals of care decisions, acceptability of neurological outcomes as well as putative means of improving decisions which may limit care...
March 18, 2023: Journal of Neurotrauma
#2
JOURNAL ARTICLE
Kristen Dams-O'Connor, Hibah O Awwad, Stuart W Hoffman, Mary Jo Pugh, Victoria Johnson, C Dirk Keene, Linda McGavern, Pratik Mukherjee, Lisa Opanashuk, Nsini Umoh, George Sopko, Henrik Zetterberg
Traumatic Brain Injury (TBI) is a risk factor for Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) and otherwise classified post-traumatic neurodegeneration (PTND). Targeted research is needed to elucidate the circumstances and mechanisms through which TBI contributes to the initiation, development, and progression of AD/ADRD pathologies including multiple etiology dementia (MED). The National Institutes of Health hosts triennial ADRD Summits to inform a national research agenda, and TBI was included for a second time in 2022...
March 16, 2023: Journal of Neurotrauma
#3
JOURNAL ARTICLE
Laura Heath, Muhammad Rafae Kidwai, Brenda Colella, Georges A Monette, Pavel Tselichtchev, Jennifer Tomaszczyk, Robin Ea Green
This study investigated longitudinal trajectories of anxiety and depressive symptoms following moderate-severe traumatic brain injury (TBI), predictors of the trajectories, and associations with 1-year return to productivity. One hundred forty-eight patients with moderate-severe TBI were assessed at 2, 5, 12, and 36+ months post-injury on the Beck Anxiety Inventory and Beck Depression Inventory. Clinical interviews obtained information about demographics, injury characteristics, and 1-year return to productivity...
March 16, 2023: Journal of Neurotrauma
#4
JOURNAL ARTICLE
Samuel S Shin, Rajarshi Chattaraj, Angela Viaene, Mrigendra Karmacharya, Sophie Haddad, Rinat Degani, Anush Sridharan, Chandra Seghal, Daeyeon Lee, Todd J Kilbaugh, Misun Hwang
Cerebrovascular dysfunction following traumatic brain injury (TBI) is a well characterized phenomenon. Given the therapeutic potential of xenon, we aimed to study its effects after localized delivery to the brain using microbubbles. We designed xenon containing microbubbles stabilized by dibehenoylphosphatidylcholine (DBPC) and polyethylene glycol (PEG) attached to saturated phospholipid (DPSE-PEG5000). Using a pig model of TBI, these microbubbles were intravenously injected, and ultrasound was used release xenon at the level of the carotid artery...
March 16, 2023: Journal of Neurotrauma
#5
JOURNAL ARTICLE
Victoria Foster, Natalie Saez, Ellen Gillespie, Trisha Jogia, Chantelle Reid, Snezana Maljevic, Woncheol Jung, Hong W Lao, Marc Jan Ruitenberg, Glen King
Acid sensing ion channel 1a (ASIC1a) is a proton-activated channel that is expressed ubiquitously throughout the central nervous system and in various types of immune cells. Its role in spinal cord injury (SCI) is controversial; inhibition of ASIC1a has been reported to improve SCI pathology on two accounts in vivo but conversely, gene ablation increased kainite-mediated excitotoxic cell death in vitro. Here, we re-examined the role of ASIC1a in a mouse model of SCI. First, we observed functional outcomes up to 42 days post-operation (DPO) in SCI mice with a selective genetic ablation of ASIC1a...
March 16, 2023: Journal of Neurotrauma
#6
EDITORIAL
Franco Servadei, Delia Cannizzaro, Ismail Zaed, Corrado Iaccarino, Andrea Cardia
No abstract text is available yet for this article.
March 9, 2023: Journal of Neurotrauma
#7
REVIEW
Beddome C Allen, Elaina Cummer, Anand K Sarma
Low- and middle-income countries (LMICs) experience the majority of traumatic brain injuries (TBIs), yet few studies have examined the epidemiology and management strategies of TBI in LMICs. The objective of this narrative review is to discuss the epidemiology of TBI within LMICs, describe the adherence to Brain Trauma Foundation (BTF) guidelines for the management of severe TBI in LMICs, and document TBI management strategies currently used in LMICs. Articles from January 1, 2009 to September 30, 2021 that included patients with TBI greater than 18 years of age in low-, low middle-, and high middle-income countries were queried in PubMed...
March 9, 2023: Journal of Neurotrauma
#8
JOURNAL ARTICLE
Mingxiong X Huang, Annemarie Angeles Quinto, Ashley Robb Swan, Bianca De-la-Garza, Charles W Huang, Chung-Kuan Cheng, John Hesselink, Erin D Bigler, Elisabeth A Wilde, Florin Vaida, Emily A Troyer, Jeffrey E Max
The objectives of this machine-learning (ML) resting-state magnetoencephalography (rs-MEG) study involving children with mild traumatic brain injury (mTBI) and orthopedic injury (OI) controls were to define a neural injury signature of mTBI and to delineate the pattern/s of neural injury that determine behavioral recovery. Children aged 8-15 years with mTBI (n=59) and OI (n=39) from consecutive admissions to an emergency department were studied prospectively for parent-rated post-concussion symptoms (PCS) at 1) baseline (average of 3 weeks postinjury) to measure preinjury symptoms and also concurrent symptoms, and 2) at 3-months postinjury...
March 8, 2023: Journal of Neurotrauma
#9
JOURNAL ARTICLE
Cathlyn Corrado, Barry Stewart Willer, Jacob I McPherson, Eileen Storey, Sue Ann Sisto, Tina Master, Douglas Wiebe, Matthew Grady, Rebekah Mannix, William Meehan, John J Leddy, Mohammad Nadir Haider
Early targeted heart rate (HR) aerobic exercise has been shown to reduce the duration of recovery from sport-related concussion (SRC) as well as the incidence of Persistent Post-Concussive Symptoms (PPCS). It is not known, however, if more severe oculomotor and vestibular presentations of SRC benefit from a prescription of aerobic exercise. The current study is an exploratory analysis of two published randomized controlled trials (RCTs) that compared aerobic exercise within 10 days of injury with a placebo-like stretching intervention...
March 8, 2023: Journal of Neurotrauma
#10
JOURNAL ARTICLE
Daniyal Mansoor Ali, Ahilan Sivaganesan, Christopher J Neal, Sara Thalheimer, Beatrice Ugiliweneza, Elizabeth G Toups, Muhammad Abd-El-Barr, George Jimsheleishvili, Shekar N Kurpad, Bizhan Aarabi, Christopher Shaffrey, Michael G Fehlings, Charles Tator, Robert Grossman, James Guest, James Shields Harrop
The bulbocavernosus reflex (BCR) has been used during the initial evaluation of a spinal cord injury patient as a metric to determine prognosis and whether the patient is in "spinal shock". This reflex has been less utilized over the last decade and therefore, a review was performed to assess the value of BCR in patient prognosis. The North American Clinical Trials Network (NACTN) for Spinal Cord Injury is a consortium of tertiary medical centers that includes a prospective SCI registry. The NACTN registry data was analyzed to evaluate the prognostic implication of the BCR during the initial evaluation of a spinal cord injury patient...
March 8, 2023: Journal of Neurotrauma
#11
JOURNAL ARTICLE
Yiteng Li, Yihao Chen, Xuyang Hu, Fangru Ouyang, Jianjian Li, Jinxin Huang, Jianan Ye, Fangli Shan, Yong Luo, Shuisheng Yu, Ziyu Li, Fei Yao, Yanchang Liu, Yi Shi, Meige Zheng, Li Cheng, Juehua Jing
Following spinal cord injury (SCI), fibrotic scar inhibits axon regeneration and impairs neurological function recovery. It has been reported that T cell-derived IFN-γ plays a pivotal role in promoting fibrotic scarring in neurodegenerative disease. However, the role of IFN-γ in fibrotic scar formation after SCI has not been declared. In this study, a spinal cord crush injury mouse was established. Western blot and immunofluorescence showed that IFN-γ was surrounded by fibroblasts at 3, 7, 14, and 28 days post-injury (dpi)...
March 6, 2023: Journal of Neurotrauma
#12
JOURNAL ARTICLE
Kristen Dams-O'Connor, Ashlyn Bulas, Halina Lin Haag, Lisa A Spielman, Angela Fernandez, Lynn Frederick-Hawley, Jeanne M Hoffman, Yelena Goldin Frazier
Intimate partner violence (IPV) is associated with risk for multi-etiology brain injury (BI), including repetitive head impacts, isolated traumatic brain injuries (TBI), and anoxic/hypoxic injury secondary to nonfatal strangulation (NFS). IPV-related injuries are often unreported, but evidence suggests that survivors are more likely to report when asked directly. There are currently no validated tools for identification or screening of brain injury related to IPV that meet World Health Organization guidelines for this population...
March 6, 2023: Journal of Neurotrauma
#13
JOURNAL ARTICLE
Afshin Andre Divani, Pascal Salazar, Hafiz Abdullah Ikram, Erik Taylor, Colin M Wilson, Yirong Yang, Javad Mahmoudi, Alina Seletska, Karen S SantaCruz, Michel Torbey, Eric Liebler, Olga A Bragina, Russell Morton, Denis E Bragin
Traumatic brain injury (TBI) continues to be a major cause of death and disability worldwide. This study assessed the effectiveness of non-invasive vagus nerve stimulation (nVNS) in reducing brain lesion volume and improving neurobehavioral performance in a rat model of TBI. Animals were randomized into 3 experimental groups: 1) TBI with sham stimulation treatment (Control), 2) TBI treated with five lower doses (2-minute) nVNS, and 3) TBI treated with five higher doses (2x2-minute) nVNS. We used the gammaCore nVNS device to deliver stimulations...
March 3, 2023: Journal of Neurotrauma
#14
JOURNAL ARTICLE
Tia Louise Cummins, Vincent Doré, Azadeh Feizpour, Natasha Krishnadas, Pierrick Bourgeat, Alby Elias, Fiona Lamb, Robert Williams, Malcolm John Hopwood, Susan Landau, Victor Villemagne, Michael Weiner, Christopher C Rowe
Traumatic Brain Injury (TBI) is common amongst military veterans and has been associated with an increased risk of dementia. It is unclear if this is due to increased risk for Alzheimer's disease (AD) or other mechanisms. This case control study sought evidence for AD, as defined by the 2018 NIA-AA research framework, by measuring tau, β-amyloid and glucose metabolism using positron emission tomography (PET) in veterans with service-related TBI. Seventy male Vietnam war veterans - 40 with TBI (aged 68...
February 28, 2023: Journal of Neurotrauma
#15
JOURNAL ARTICLE
Pratik Mukherjee, Eva M Palacios, Geoffrey T Manley
Dr Hutchinson raises some important points regarding the imaging evaluation of acute mild TBI (mTBI). We agree that attrition is an important consideration in longitudinal studies and the effects of attrition can be assessed by the CONSORT diagram we provided in our study1. We also agree that most acute mTBI patients experience substantial recovery during the weeks to months following their injury. Indeed, this may help explain another point Dr. Hutchinson made about the relative lack of involvement of the corpus callosum in our diffusion tensor imaging (DTI) study...
February 28, 2023: Journal of Neurotrauma
#16
JOURNAL ARTICLE
Characterizing factors influencing baseline plasma biomarkers for sport-related concussion in youth.
Jason Tabor, Linden Penner, Jennifer Cooper, Mohammad Ghodsi, Jean-Michel Galarneau, Douglas D Fraser, Carolyn Emery, Cheryl L Wellington, Chantel T Debert
Developing objective means to clinically diagnose sport-related concussion (SRC) is a top priority in sport medicine, particularly in the pediatric context given the vulnerability of the developing brain. While advances in SRC blood biomarkers are being made in adult populations, little work is being done in youth. Clinical validation of these biomarkers post-SRC will first require investigation into their presentation in a healthy uninjured state. Furthermore, rapid pubertal changes in this age group may implicate possible interactions with circulating sex hormones, and specifically the menstrual cycle for female athletes...
February 27, 2023: Journal of Neurotrauma
#17
JOURNAL ARTICLE
Brittany G Futch, Romaric Waguia Kouam, Beatrice Ugiliweneza, James Shields Harrop, Shekar N Kurpad, Norah Foster, Khoi Than, Clifford Crutcher, C Rory Goodwin, Charles Tator, Christopher Shaffrey, Bizhan Aarabi, Michael G Fehlings, Christopher J Neal, James Guest, Muhammad Abd-El-Barr
There is a paucity of data comparing the demographics, mechanism of injury, and outcomes of upper versus lower cervical spinal cord injuries (cSCI). The study objective was to define different clinical manifestations of cSCI. Data were collected prospectively through centers of the North American Clinical Trials Network (NACTN). Data was collected on 470 patients (21% women, mean age 50 years). Cervical vertebral level was analyzed as an ordinal variable to determine a natural demarcation to classify upper versus lower cSCI...
February 27, 2023: Journal of Neurotrauma
#18
JOURNAL ARTICLE
Naomi Ketharanathan, Maayke A W Hunfeld, Marcus C de Jong, Lineke J van der Zanden, Jochem K H Spoor, Enno D Wildschut, Matthijs de Hoog, Dick Tibboel, Corinne M P Buysse
Neuroprognostication in severe traumatic brain injury (sTBI) is challenging and occurs in critical care settings to determine withdrawal of life-sustaining therapies (WLST). However, formal pediatric sTBI neuroprognostication guidelines are lacking, brain death criteria vary, and dilemmas regarding WLST persist, which lead to institutional differences. We studied WLST practice and outcome in pediatric sTBI to provide insight into WLST-associated factors and survivor recovery trajectory ≥1 year post-sTBI...
February 27, 2023: Journal of Neurotrauma
#19
JOURNAL ARTICLE
Tamara Wexler, Kent Reifschneider, Philippe Backeljauw, Javier F Cardenas, Andrew R Hoffman, Bradley S Miller, Kevin Cj Yuen
Traumatic brain injury (TBI) is increasingly recognized with an incidence of approximately 110 per 100,000 in pediatric populations and 618 per 100,000 in adolescent and adult populations. TBI often leads to cognitive, behavioral, and physical consequences, including endocrinopathies. Deficiencies in anterior pituitary hormones (eg, adrenocorticotropic hormone, thyroid-stimulating hormone, gonadotropins, and growth hormone [GH]) can negatively impact health outcomes and quality of life post TBI. This review focuses on GH deficiency (GHD), the most common post-TBI pituitary hormone deficiency...
February 24, 2023: Journal of Neurotrauma
#20
JOURNAL ARTICLE
Michael Hutchinson
There is no abstract.
February 24, 2023: Journal of Neurotrauma
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