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Journals Journal of Neurology, Neurosur...

Journal of Neurology, Neurosurgery, and Psychiatry

https://read.qxmd.com/read/38383155/therapeutic-interventions-increasing-seizure-risk-in-multiple-sclerosis-resolving-discordant-meta-analyses
#21
EDITORIAL
John P Ioannidis
No abstract text is available yet for this article.
February 21, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38383154/genotype-specific-spinal-cord-damage-in-spinocerebellar-ataxias-an-enigma-ataxia-study
#22
JOURNAL ARTICLE
Thiago Junqueira Ribeiro Rezende, Isaac Adanyaguh, Orlando G P Barsottini, Benjamin Bender, Fernando Cendes, Leo Coutinho, Andreas Deistung, Imis Dogan, Alexandra Durr, Juan Fernandez-Ruiz, Sophia L Göricke, Marina Grisoli, Carlos R Hernandez-Castillo, Christophe Lenglet, Caterina Mariotti, Alberto R M Martinez, Breno K Massuyama, Fanny Mochel, Lorenzo Nanetti, Anna Nigri, Sergio E Ono, Gülin Öz, José Luiz Pedroso, Kathrin Reetz, Matthis Synofzik, Helio Teive, Sophia I Thomopoulos, Paul M Thompson, Dagmar Timmann, Bart P C van de Warrenburg, Judith van Gaalen, Marcondes C França, Ian H Harding
BACKGROUND: Spinal cord damage is a feature of many spinocerebellar ataxias (SCAs), but well-powered in vivo studies are lacking and links with disease severity and progression remain unclear. Here we characterise cervical spinal cord morphometric abnormalities in SCA1, SCA2, SCA3 and SCA6 using a large multisite MRI dataset. METHODS: Upper spinal cord (vertebrae C1-C4) cross-sectional area (CSA) and eccentricity (flattening) were assessed using MRI data from nine sites within the ENIGMA-Ataxia consortium, including 364 people with ataxic SCA, 56 individuals with preataxic SCA and 394 nonataxic controls...
February 21, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38341197/excellent-response-to-anti-cd38-therapy-with-daratumumab-in-a-patient-with-severe-refractory-canomad
#23
JOURNAL ARTICLE
Elba Pascual-Goñi, Roger Collet, Clara Tejada-Illa, Lorena Martín-Aguilar, Marta Caballero-Ávila, Cinta Lleixà, Silvana Novelli, Jordi López-Pardo, Albert Esquirol Sanfeliu, Anais Mariscal, Yolanda Álvaro Gargallo, Eugenia Martínez-Hernández, Dolores Cocho, Luis Querol
BACKGROUND: Intravenous immunoglobulin (IVIG) and rituximab are considered the first-line and second-line treatments for Chronic Ataxic Neuropathy and Ophthalmoplegia with IgM-paraprotein, cold Agglutinins, and anti-Disialosyl antibodies (CANOMAD), with an overall clinical response around 50%. New anti-CD38 daratumumab, targeting long-lived plasma cells, has been reported as a promising therapy for treatment-refractory antibody-mediated disorders. We report the first case of a severe refractory CANOMAD, successfully treated with daratumumab...
February 10, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38267207/flavonoid-intake-and-risk-of-parkinson-s-disease
#24
JOURNAL ARTICLE
Helena Sandoval-Insausti, Mario H Flores-Torres, Kjetil Bjornevik, Marianna Cortese, Albert Y Hung, Michael Schwarzschild, Tian-Shin Yeh, Alberto Ascherio
BACKGROUND: Flavonoids have been proposed to reduce the risk of Parkinson's disease (PD). However, results from epidemiological studies have been inconclusive. OBJECTIVE: To prospectively examine the association between the intake of flavonoids and their subclasses and the risk of PD and how pesticides may confound or modify that association. METHODS: The study population comprised 80 701 women (1984-2016) and 48 782 men (1986-2016) from two large US cohorts...
February 6, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38302433/the-influence-of-epigenetic-biological-age-on-key-complications-and-outcomes-in-aneurysmal-subarachnoid-haemorrhage
#25
JOURNAL ARTICLE
Adrià Macias-Gómez, Joan Jiménez-Balado, Isabel Fernández-Pérez, Antoni Suárez-Pérez, Marta Vallverdú-Prats, Leopoldo Guimaraens, Elio Vivas, Jesus Saldaña, Eva Giralt-Steinhauer, Daniel Guisado-Alonso, Gloria Villalba, Maria-Pilar Gracia, Manel Esteller, Ana Rodriguez-Campello, Jordi Jiménez-Conde, Angel Ois, Elisa Cuadrado-Godia
BACKGROUND: We aimed to investigate the association between DNA-methylation biological age (B-age) calculated as age acceleration (ageAcc) and key aneurysmal subarachnoid haemorrhage (aSAH) complications such as vasospasm, delayed cerebral ischaemia (DCI), poor outcome, and mortality. METHODS: We conducted a prospective study involving 277 patients with aSAH. B-age was determined in whole blood samples using five epigenetic clocks: Hannum's, Horvath's, Levine's and both versions of Zhang's clocks...
February 1, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38253362/nfl-reliability-across-laboratories-stage-dependent-diagnostic-performance-and-matrix-comparability-in-genetic-ftd-a-large-genfi-study
#26
JOURNAL ARTICLE
Christoph Linnemann, Carlo Wilke, David Mengel, Henrik Zetterberg, Carolin Heller, Jens Kuhle, Arabella Bouzigues, Lucy L Russell, Phoebe H Foster, Eve Ferry-Bolder, John Cornelis Van Swieten, Lize C Jiskoot, Harro Seelaar, Fermin Moreno, Barbara Borroni, Raquel Sánchez-Valle, Daniela Galimberti, Robert Laforce, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James Benedict Rowe, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonca, Chris R Butler, Alexander Gerhard, Simon Ducharme, Isabelle L E Ber, Pietro Tiraboschi, Isabel Santana, Florence Pasquier, Johannes Levin, Markus Otto, Sandro Sorbi, Jonathan Daniel Rohrer, Matthis Synofzik
BACKGROUND: Blood neurofilament light chain (NfL) is increasingly considered as a key trial biomarker in genetic frontotemporal dementia (gFTD). We aimed to facilitate the use of NfL in gFTD multicentre trials by testing its (1) reliability across labs; (2) reliability to stratify gFTD disease stages; (3) comparability between blood matrices and (4) stability across recruiting sites. METHODS: Comparative analysis of blood NfL levels in a large gFTD cohort (GENFI) for (1)-(4), with n=344 samples (n=148 presymptomatic, n=11 converter, n=46 symptomatic subjects, with mutations in C9orf72 , GRN or MAPT ; and n=139 within-family controls), each measured in three different international labs by Simoa HD-1 analyzer...
February 1, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38290839/cardiometabolic-risk-factors-and-neurodegeneration-a-review-of-the-mechanisms-underlying-diabetes-obesity-and-hypertension-in-alzheimer-s-disease
#27
REVIEW
Vijay Patel, Paul Edison
A growing body of evidence suggests that cardiometabolic risk factors play a significant role in Alzheimer's disease (AD). Diabetes, obesity and hypertension are highly prevalent and can accelerate neurodegeneration and perpetuate the burden of AD. Insulin resistance and enzymes including insulin degrading enzymes are implicated in AD where breakdown of insulin is prioritised over amyloid-β. Leptin resistance and inflammation demonstrated by higher plasma and central nervous system levels of interleukin-6 (IL-6), IL-1β and tumour necrosis factor-α, are mechanisms connecting obesity and diabetes with AD...
January 30, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38290838/the-mog-antibody-non-p42-epitope-is-predictive-of-a-relapsing-course-in-mog-antibody-associated-disease
#28
JOURNAL ARTICLE
Ganesha Liyanage, Benjamin P Trewin, Joseph A Lopez, Jane Andersen, Fiona Tea, Vera Merheb, Kristy Nguyen, Fiona X Z Lee, Marzena J Fabis-Pedrini, Alicia Zou, Ali Buckland, Anthony Fok, Michael H Barnett, Stephen W Reddel, Romain Marignier, Aseel El Hajj, Mastura Monif, Anneke van der Walt, Jeannette Lechner-Scott, Allan G Kermode, Tomas Kalincik, Simon A Broadley, Russell C Dale, Sudarshini Ramanathan, Fabienne Brilot
BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG) IgG seropositivity is a prerequisite for MOG antibody-associated disease (MOGAD) diagnosis. While a significant proportion of patients experience a relapsing disease, there is currently no biomarker predictive of disease course. We aim to determine whether MOG-IgG epitopes can predict a relapsing course in MOGAD patients. METHODS: MOG-IgG-seropositive confirmed adult MOGAD patients were included (n=202). Serum MOG-IgG and epitope binding were determined by validated flow cytometry live cell-based assays...
January 30, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38290837/prevalence-and-burden-of-pain-across-the-entire-spectrum-of-huntington-s-disease
#29
JOURNAL ARTICLE
Gregory P Sprenger, Erik W van Zwet, Hannah S Bakels, Wilco P Achterberg, Raymund A Roos, Susanne T de Bot
BACKGROUND: Pain is an important symptom in Huntington's disease (HD), however, not systematically studied and understood. The objective of the current study is to assess the prevalence of pain, pain interference in daily activities, painful conditions, analgesic use and the severity of the pain burden across different disease stages and 'Age at symptom Onset' groups. Additionally, the association between pain and disease burden was investigated. METHODS: A cross-sectional analysis was conducted within two large data sets, which included different types of pain scales...
January 30, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38272656/on-off-non-motor-evaluation-a-new-way-to-evaluate-non-motor-fluctuations-in-parkinson-s-disease
#30
JOURNAL ARTICLE
Florent Faggianelli, Tatiana Witjas, J-P Azulay, Isabelle Benatru, Cécile Hubsch, Mathieu Anheim, Caroline Moreau, Elodie Hainque, Sophie Drapier, Béchir Jarraya, Chloé Laurencin, Dominique Guehl, Lucie Hopes, Christine Brefel-Courbon, Melissa Tir, Ana Marques, Tiphaine Rouaud, David Maltete, Caroline Giordana, Karine Baumstarck, Olivier Rascol, Jean Christophe Corvol, Anne-Sophie Rolland, David Devos, Alexandre Eusebio
BACKGROUND: NMF are currently poorly evaluated in therapeutic decisions. A quantification of their severity would facilitate their integration. The objective of this study was to validate an autoquestionnaire evaluating the severity of non-motor fluctuations (NMF) in Parkinson's disease (PD). METHODS: Patients with PD were included in presurgical situation for deep brain stimulation of subthalamic nuclei. They participated in the PREDISTIM cohort (a study evaluating the predictive factors for therapeutic response of subthalamic stimulation in PD) in 17 centres in France...
January 25, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38242680/emulating-randomised-clinical-trials-in-relapsing-remitting-multiple-sclerosis-with-non-randomised-real-world-evidence-an-application-using-data-from-the-msbase-registry
#31
JOURNAL ARTICLE
Alessio Signori, Marta Ponzano, Tomas Kalincik, Serkan Ozakbas, Dana Horakova, Eva Kubala Havrdova, Raed Alroughani, Francesco Patti, Jens Kuhle, Guillermo Izquierdo, Sara Eichau, Bassem Yamout, Samia Joseph Khoury, Rana Karabudak, Pierre Grammond, Pierre Duquette, Izanne Roos, Helmut Butzkueven, Anneke van der Walt, Maria Pia Sormani
BACKGROUND: To mimic as closely as possible a randomised controlled trial (RCT) and calibrate the real-world evidence (RWE) studies against a known treatment effect would be helpful to understand if RWE can support causal conclusions in selected circumstances. The aim was to emulate the TRANSFORMS trial comparing Fingolimod (FTY) versus intramuscular interferon β-1a (IFN) using observational data. METHODS: We extracted from the MSBase registry all the patients with relapsing-remitting multiple sclerosis (RRMS) collected in the period 2011-2021 who received IFN or FTY (0...
January 19, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38242679/functional-parcellation-of-the-cingulate-gyrus-by-electrical-cortical-stimulation-a-synthetic-literature-review-and-future-directions
#32
JOURNAL ARTICLE
Rawan Mahgoub, Ayse Kacar Bayram, Dennis D Spencer, Rafeed Alkawadri
BACKGROUND: The cingulate gyrus (CG), a brain structure above the corpus callosum, is recognised as part of the limbic system and plays numerous vital roles. However, its full functional capacity is yet to be understood. In recent years, emerging evidence from imaging modalities, supported by electrical cortical stimulation (ECS) findings, has improved our understanding. To our knowledge, there is a limited number of systematic reviews of the cingulate function studied by ECS. We aim to parcellate the CG by reviewing ECS studies...
January 19, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38212060/psck9-inhibitors-reduced-early-recurrent-stroke-in-patients-with-symptomatic-intracranial-atherosclerotic-stenosis
#33
JOURNAL ARTICLE
Li Wu, Bo Zhang, Chenghao Li, Zhuolin Zhuang, Kang Liu, Hualin Chen, Shuanggen Zhu, Juehua Zhu, Zheng Dai, Huameng Huang, Yongjun Jiang
BACKGROUND: Symptomatic intracranial atherosclerotic stenosis (ICAS) is prone to cause early recurrent stroke (ERS). Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors lower low-density lipoprotein cholesterol (LDL-C) levels and prevent cardiovascular events. This multicentre, hospital-based prospective cohort study was designed to investigate whether PCSK9 inhibitors would prevent ERS in patients with symptomatic ICAS. METHODS: From 1 October 2020 to 30 September 2022, consecutive patients with acute ischaemic stroke attributed to ICAS admitted within 1 week after onset were enrolled and followed up for 1 month...
January 11, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38212059/impact-of-white-matter-networks-on-risk-for-memory-decline-following-resection-versus-ablation-in-temporal-lobe-epilepsy
#34
JOURNAL ARTICLE
Erik Kaestner, Alena Stasenko, Adam Schadler, Rebecca Roth, Kelsey Hewitt, Anny Reyes, Deqiang Qiu, Leonardo Bonilha, Natalie Voets, Ranliang Hu, Jon Willie, Nigel Pedersen, Jerry Shih, Sharona Ben-Haim, Robert Gross, Daniel Drane, Carrie R McDonald
BACKGROUND: With expanding neurosurgical options in epilepsy, it is important to characterise each options' risk for postoperative cognitive decline. Here, we characterise how patients' preoperative white matter (WM) networks relates to postoperative memory changes following different epilepsy surgeries. METHODS: Eighty-nine patients with temporal lobe epilepsy with T1-weighted and diffusion-weighted imaging as well as preoperative and postoperative verbal memory scores (prose recall) underwent either anterior temporal lobectomy (ATL: n=38) or stereotactic laser amygdalohippocampotomy (SLAH; n=51)...
January 11, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38212058/head-trauma-results-in-manyfold-increased-risk-of-multiple-sclerosis-in-genetically-susceptible-individuals
#35
JOURNAL ARTICLE
Eva Johansson, Lars Alfredsson, Pernilla Strid, Ingrid Kockum, Tomas Olsson, Anna Karin Hedström
BACKGROUND: Large register-based studies have reported an association between head trauma and increased risk of multiple sclerosis (MS). We aimed to investigate possible interactions between head trauma and MS-associated HLA genes in relation to MS risk. METHODS: We used a Swedish population-based case-control study (2807 incident cases, 5950 matched controls with HLA genotypes available for 2057 cases, 2887 controls). Subjects with and without a history of self-reported head trauma were compared regarding MS risk, by calculating ORs with 95% CIs using logistic regression models...
January 11, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38199813/rates-of-cortical-thinning-in-alzheimer-s-disease-signature-regions-associate-with-vascular-burden-but-not-with-%C3%AE-amyloid-status-in-cognitively-normal-adults-at-age-70
#36
JOURNAL ARTICLE
Sarah E Keuss, William Coath, David M Cash, Josephine Barnes, Jennifer M Nicholas, Christopher A Lane, Thomas D Parker, Ashvini Keshavan, Sarah M Buchanan, Aaron Z Wagen, Mathew Storey, Matthew Harris, Kirsty Lu, Sarah-Naomi James, Rebecca Street, Ian B Malone, Carole H Sudre, David L Thomas, John C Dickson, Frederik Barkhof, Heidi Murray-Smith, Andrew Wong, Marcus Richards, Nick C Fox, Jonathan M Schott
BACKGROUND: Consistent patterns of reduced cortical thickness have been identified in early Alzheimer's disease (AD). However, the pathological factors that influence rates of cortical thinning within these AD signature regions remain unclear. METHODS: Participants were from the Insight 46 substudy of the MRC National Survey of Health and Development (NSHD; 1946 British birth cohort), a prospective longitudinal cohort study. Linear regression was used to examine associations of baseline cerebral β-amyloid (Aβ) deposition, measured using florbetapir positron emission tomography, and baseline white matter hyperintensity volume (WMHV) on MRI, a marker of cerebral small vessel disease, with subsequent longitudinal changes in AD signature cortical thickness quantified from baseline and repeat MRI (mean [SD] interval 2...
January 10, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38176896/long-term-disability-progression-in-aquaporin-4-antibody-positive-neuromyelitis-optica-spectrum-disorder-a-retrospective-analysis-of-101-patients
#37
JOURNAL ARTICLE
Akiyuki Uzawa, Masahiro Mori, Hiroki Masuda, Tomohiko Uchida, Mayumi Muto, Ryohei Ohtani, Shinji Aoyama, Satoshi Kuwabara
BACKGROUND: Anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4Ab+NMOSD) is an inflammatory disorder of the central nervous system with relapse-dependent progression. Few studies have reported the effects of prednisolone and biologics on disability progression in AQP4Ab+NMOSD, although it is established that they prevent clinical relapses. This retrospective study investigated long-term disability progression and the effects of therapeutic interventions on disability progression in AQP4Ab+NMOSD...
January 4, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38071545/improved-naming-in-patients-with-broca-s-aphasia-with-tdcs
#38
RANDOMIZED CONTROLLED TRIAL
Leonardo Bonilha, Chris Rorden, Rebecca Roth, Souvik Sen, Mark S George, Julius Fridriksson
BACKGROUND: Language impairment (aphasia) is a common neurological deficit after strokes. For individuals with chronic aphasia (beyond 6 months after the stroke), language improvements with speech therapy (ST) are often limited. Transcranial direct current stimulation (tDCS) is a promising approach to complement language recovery but interindividual variability in treatment response is common after tDCS, suggesting a possible relationship between tDCS and type of linguistic impairment (aphasia type)...
February 14, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37775267/beyond-antithrombotics-recent-advances-in-pharmacological-risk-factor-management-for-secondary-stroke-prevention
#39
REVIEW
Dimitrios Sagris, George Ntaios, Haralampos Milionis
Patients with ischaemic stroke represent a diverse group with several cardiovascular risk factors and comorbidities, which classify them as patients at very high risk of stroke recurrence, cardiovascular adverse events or death. In addition to antithrombotic therapy, which is important for secondary stroke prevention in most patients with stroke, cardiovascular risk factor assessment and treatment also contribute significantly to the reduction of mortality and morbidity. Dyslipidaemia, diabetes mellitus and hypertension represent common and important modifiable cardiovascular risk factors among patients with stroke, while early recognition and treatment may have a significant impact on patients' future risk of major cardiovascular events...
February 14, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37679030/cognitive-and-psychiatric-outcomes-in-the-galaxy-trial-effect-of-anaesthesia-in-deep-brain-stimulation
#40
RANDOMIZED CONTROLLED TRIAL
Rozemarije A Holewijn, Thomas J C Zoon, Dagmar Verbaan, Isidoor O Bergfeld, Esmée Verwijk, Gert J Geurtsen, Geeske van Rooijen, Pepijn van den Munckhof, Maarten Bot, Damiaan A J P Denys, Rob M A De Bie, P Rick Schuurman
BACKGROUND: This study aims: (1) To compare cognitive and psychiatric outcomes after bilateral awake versus asleep subthalamic nucleus (STN) deep brain stimulation (DBS) surgery for Parkinson's disease (PD). (2) To explore the occurrence of psychiatric diagnoses, cognitive impairment and quality of life after surgery in our whole sample. (3) To validate whether we can predict postoperative cognitive decline. METHODS: 110 patients with PD were randomised to receive awake (n=56) or asleep (n=54) STN DBS surgery...
February 14, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
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