journal
Journals Journal of Neurology, Neurosur...

Journal of Neurology, Neurosurgery, and Psychiatry

https://read.qxmd.com/read/37989568/marked-laterality-of-olivopontocerebellar-pathology-in-an-autopsied-patient-with-msa-implications-for-degeneration-and-%C3%AE-synuclein-propagation
#1
LETTER
Misato Ozawa, Rie Saito, Takuya Konno, Reiji Koide, Shigeru Fujimoto, Osamu Onodera, Akiyoshi Kakita
No abstract text is available yet for this article.
November 21, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37989567/how-effective-is-effective-enough
#2
EDITORIAL
Tomas Kalincik, Amy Brodtmann
No abstract text is available yet for this article.
November 21, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37989566/predictive-value-of-retinal-atrophy-for-cognitive-decline-across-disease-duration-in-multiple-sclerosis
#3
JOURNAL ARTICLE
Salut Alba-Arbalat, Elisabeth Solana, Elisabet Lopez-Soley, Anna Camos-Carreras, Eloy Martinez-Heras, Francesc Vivó, Irene Pulido-Valdeolivas, Magi Andorra, Maria Sepulveda, Jose María Cabrera, Elianet Fonseca, Alberto Calvi, Rafel Alcubierre, Marina Dotti-Boada, Albert Saiz, Elena H Martinez-Lapiscina, Pablo Villoslada, Yolanda Blanco, Bernardo Sanchez-Dalmau, Sara Llufriu
BACKGROUND: We investigated the association between changes in retinal thickness and cognition in people with MS (PwMS), exploring the predictive value of optical coherence tomography (OCT) markers of neuroaxonal damage for global cognitive decline at different periods of disease. METHOD: We quantified the peripapillary retinal nerve fibre (pRFNL) and ganglion cell-inner plexiform (GCIPL) layers thicknesses of 207 PwMS and performed neuropsychological evaluations...
November 21, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37979968/quantitative-mri-outcome-measures-in-cmt1a-using-automated-lower-limb-muscle-segmentation
#4
JOURNAL ARTICLE
Luke F O'Donnell, Menelaos Pipis, John S Thornton, Baris Kanber, Stephen Wastling, Amy McDowell, Nick Zafeiropoulos, Matilde Laura, Mariola Skorupinska, Christopher J Record, Carolynne M Doherty, David N Herrmann, Henrik Zetterberg, Amanda J Heslegrave, Rhiannon Laban, Alexander M Rossor, Jasper M Morrow, Mary M Reilly
BACKGROUND: Lower limb muscle magnetic resonance imaging (MRI) obtained fat fraction (FF) can detect disease progression in patients with Charcot-Marie-Tooth disease 1A (CMT1A). However, analysis is time-consuming and requires manual segmentation of lower limb muscles. We aimed to assess the responsiveness, efficiency and accuracy of acquiring FF MRI using an artificial intelligence-enabled automated segmentation technique. METHODS: We recruited 20 CMT1A patients and 7 controls for assessment at baseline and 12 months...
November 18, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37979967/comparison-of-relative-change-with-effect-size-metrics-in-alzheimer-s-disease-clinical-trials
#5
JOURNAL ARTICLE
Terry E Goldberg, Seonjoo Lee, Davangere P Devanand, Lon S Schneider
BACKGROUND: Per cent slowing of decline is frequently used as a metric of outcome in Alzheimer's disease (AD) clinical trials, but it may be misleading. Our objective was to determine whether per cent slowing of decline or Cohen's d is the more valid and informative measure of efficacy. METHODS: Outcome measures of interest were per cent slowing of decline; Cohen's d effect size and number-needed-to-treat (NNT). Data from a graphic were used to model the inter-relationships among Cohen's d, placebo decline in raw score units and per cent slowing of decline with active treatment...
November 18, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37979966/evolution-of-brain-mri-lesions-in-paediatric-myelin-oligodendrocyte-glycoprotein-antibody-associated-disease-mogad-and-its-relevance-to-disease-course
#6
JOURNAL ARTICLE
Omar Abdel-Mannan, Dimitrios Champsas, Carmen Tur, Vanessa Lee, Sharmila Manivannan, Haroon Usman, Alison Skippen, Ishita Desai, Manali Chitre, Rob Forsyth, Rachel Kneen, Dipak Ram, Sithara Ramdas, Thomas Rossor, Siobhan West, Sukhvir Wright, Jacqueline Palace, Evangeline Wassmer, Cheryl Hemingway, Ming J Lim, Kshitij Mankad, Olga Ciccarelli, Yael Hacohen
BACKGROUND: Lesion resolution is often observed in children with myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD), and asymptomatic lesions are less commonly reported in MOGAD than in multiple sclerosis (MS). OBJECTIVE: We aimed to evaluate brain MRI changes over time in paediatric MOGAD. METHODS: Retrospective study in eight UK paediatric neuroscience centres. Acute brain MRI and available follow-up MRIs were reviewed...
November 18, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37967935/dementia-prevention-the-mendelian-randomisation-perspective
#7
JOURNAL ARTICLE
Emma Louise Anderson, Neil M Davies, Roxanna Korologou-Linden, Mika Kivimäki
Understanding the causes of Alzheimer's disease and related dementias remains a challenge. Observational studies investigating dementia risk factors are limited by the pervasive issues of confounding, reverse causation and selection biases. Conducting randomised controlled trials for dementia prevention is often impractical due to the long prodromal phase and the inability to randomise many potential risk factors. In this essay, we introduce Mendelian randomisation as an alternative approach to examine factors that may prevent or delay Alzheimer's disease...
November 15, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37963724/prospective-trial-of-natalizumab-personalised-extended-interval-dosing-by-therapeutic-drug-monitoring-in-relapsing-remitting-multiple-sclerosis-next-ms
#8
EDITORIAL
Marcus Koch
No abstract text is available yet for this article.
November 14, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37963723/prospective-trial-of-natalizumab-personalised-extended-interval-dosing-by-therapeutic-drug-monitoring-in-relapsing-remitting-multiple-sclerosis-next-ms
#9
JOURNAL ARTICLE
Alyssa A Toorop, Zoë Ygj van Lierop, Liza My Gelissen, Elske Hoitsma, Esther Mpe Zeinstra, Luuk C van Rooij, Caspar Ep van Munster, Anke Vennegoor, Jop P Mostert, Beatrijs Ha Wokke, Nynke F Kalkers, Erwin Lj Hoogervorst, Jeroen Jj van Eijk, Christiaan M Roosendaal, Jolijn J Kragt, Marijke Eurelings, Jessie van Genugten, Jessica Nielsen, Lgf Sinnige, Mark E Kloosterziel, Edo Pj Arnoldus, Gert W van Dijk, Willem H Bouvy, Mark Hj Wessels, Lynn Boonkamp, Eva Mm Strijbis, Bob W van Oosten, Brigit A De Jong, Birgit I Lissenberg-Witte, Frederik Barkhof, Bastiaan Moraal, Charlotte E Teunissen, Theo Rispens, Bernard Mj Uitdehaag, Joep Killestein, Zoé LE van Kempen
BACKGROUND: Extended interval dosing (EID) of natalizumab is a promising strategy to optimise treatment in multiple sclerosis (MS). Personalised EID by therapeutic drug monitoring can enable further extension of treatment intervals. METHODS: The NEXT-MS trial is an investigator-initiated prospective phase IV non-randomised study. Adults with a diagnosis of relapsing-remitting MS who received ≥6 natalizumab infusions were included in three groups: personalised EID with a target drug trough concentration of 10 µg/mL (EID10), an exploratory group of personalised EID with a target of 5 µg/mL (EID5) and standard interval dosing (SID) of 4 weeks...
November 14, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37963722/unravelling-the-influence-of-affective-stimulation-on-functional-neurological-symptoms-a-pilot-experiment-examining-potential-mechanisms
#10
JOURNAL ARTICLE
Susannah Pick, Ls Merritt Millman, Emily Ward, Eleanor Short, Biba Stanton, Aat Simone Reinders, Joel S Winston, Timothy R Nicholson, Mark J Edwards, Laura H Goldstein, Anthony S David, Trudie Chalder, Matthew Hotopf, Mitul A Mehta
BACKGROUND: Differences in affective processing have previously been shown in functional neurological disorder (FND); however, the mechanistic relevance is uncertain. We tested the hypotheses that highly arousing affective stimulation would result in elevated subjective functional neurological symptoms (FNS), and this would be associated with elevated autonomic reactivity. The possible influence of cognitive detachment was also explored. METHOD: Individuals diagnosed with FND (motor symptoms/seizures; n=14) and healthy controls (n=14) viewed Positive, Negative and Neutral images in blocks, while passively observing the stimuli ('Watch') or detaching themselves ('Distance')...
November 14, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37940409/serum-biomarker-levels-predict-disability-progression-in-patients-with-primary-progressive-multiple-sclerosis
#11
JOURNAL ARTICLE
Nicolás Fissolo, Pascal Benkert, Jaume Sastre-Garriga, Neus Mongay-Ochoa, Andreu Vilaseca-Jolonch, Sara Llufriu, Yolanda Blanco, Harald Hegen, Klaus Berek, Francisco Perez-Miralles, Konrad Rejdak, Luisa M Villar, Enric Monreal, Roberto Alvarez-Lafuente, Onder K Soylu, Ahmed Abdelhak, Franziska Bachhuber, Hayrettin Tumani, Sergio Martínez-Yélamos, Antonio J Sánchez-López, Antonio García-Merino, Lucía Gutiérrez, Tamara Castillo-Trivino, Jan Lycke, Igal Rosenstein, Roberto Furlan, Massimo Filippi, Nieves Téllez, Lluís Ramió-Torrentà, Jan D Lünemann, Heinz Wiendl, Sara Eichau, Michael Khalil, Jens Kuhle, Xavier Montalban, Manuel Comabella
BACKGROUND: We aimed to investigate the potential of serum biomarker levels to predict disability progression in a multicentric real-world cohort of patients with primary progressive multiple sclerosis (PPMS). METHODS: A total of 141 patients with PPMS from 18 European MS centres were included. Disability progression was investigated using change in Expanded Disability Status Scale (EDSS) score over three time intervals: baseline to 2 years, 6 years and to the last follow-up...
November 8, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37926442/clinical-biomarker-based-biological-ageing-and-future-risk-of-neurological-disorders-in-the-uk-biobank
#12
JOURNAL ARTICLE
Jonathan K L Mak, Christopher E McMurran, Sara Hägg
BACKGROUND: Many common neurological disorders are associated with advancing chronological age, but their association with biological age (BA) remains poorly understood. METHODS: We studied 325 870 participants in the UK Biobank without a diagnosed neurological condition at baseline and generated three previously-described measures of BA based on 18 routinely measured clinical biomarkers (PhenoAge, Klemera-Doubal method age (KDMAge), homeostatic dysregulation age)...
November 5, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37918904/use-tolerability-benefits-and-side-effects-of-orthotic-devices-in-charcot-marie-tooth-disease
#13
JOURNAL ARTICLE
Alessandro Bertini, Fiore Manganelli, Gian Maria Fabrizi, Angelo Schenone, Lucio Santoro, Tiziana Cavallaro, Matteo Tagliapietra, Marina Grandis, Stefano Carlo Previtali, Yuri Matteo Falzone, Isabella Allegri, Luca Padua, Costanza Pazzaglia, Irene Tramacere, Eleonora Cavalca, Paola Saveri, Andrea Quattrone, Paola Valentino, Stefano Tozza, Luca Gentile, Massimo Russo, Anna Mazzeo, Giuseppe Vita, Valeria Prada, Riccardo Zuccarino, Francesco Ferraro, Chiara Pisciotta, Davide Pareyson
BACKGROUND: Shoe inserts, orthopaedic shoes, ankle-foot orthoses (AFOs) are important devices in Charcot-Marie-Tooth disease (CMT) management, but data about use, benefits and tolerance are scanty. METHODS: We administered to Italian CMT Registry patients an online ad hoc questionnaire investigating use, complications and perceived benefit/tolerability/emotional distress of shoe inserts, orthopaedic shoes, AFOs and other orthoses/aids. Patients were also asked to fill in the Quebec User Evaluation of Satisfaction with assistive Technology questionnaire, rating satisfaction with currently used AFO and related services...
November 2, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37918903/exploring-the-cost-effectiveness-of-ebv-vaccination-to-prevent-multiple-sclerosis-in-an-australian-setting
#14
JOURNAL ARTICLE
Andrew J Palmer, Ting Zhao, Bruce V Taylor, Ingrid van der Mei, Julie A Campbell
BACKGROUND: Increasing evidence suggests the potential of Epstein-Barr virus (EBV) vaccination in preventing multiple sclerosis (MS). We aimed to explore the cost-effectiveness of a hypothetical EBV vaccination to prevent MS in an Australian setting. METHODS: A five-state Markov model was developed to simulate the incidence and subsequent progression of MS in a general Australian population. The model inputs were derived from published Australian sources. Hypothetical vaccination costs, efficacy and strategies were derived from literature...
November 2, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37890986/methodological-considerations-for-observational-studies-of-treatment-effectiveness-in-neurology-a-clinician-s-guide
#15
REVIEW
Tomas Kalincik, Izanne Roos, Sifat Sharmin, Charles B Malpas
Data from cohorts, registries, randomised trials, electronic medical records and administrative claims databases have increasingly been used to inform the use of therapies for neurological diseases. While novel sophisticated methods are enabling us to use existing data to guide treatment decisions, the complexity of statistical methodology is making appraisal of clinical evidence increasingly demanding. In this narrative review, we provide a brief overview of the most commonly used methods for evaluation of treatment effectiveness in neurology...
October 27, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37890985/haemorrhagic-myelitis-as-a-manifestation-of-mog-antibody-associated-disease
#16
LETTER
Jonathan Ciron, Damien Biotti, Chloé Bost, Fabrice Bonneville, Romain Marignier
No abstract text is available yet for this article.
October 27, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37884346/using-qualitative-free-text-data-to-investigate-the-lived-experience-of-the-covid-19-pandemic-for-a-large-cohort-of-australians-with-different-multiple-sclerosis-related-disability-levels
#17
JOURNAL ARTICLE
Julie A Campbell, Ingrid van der Mei, Bruce V Taylor, Andrew J Palmer, Glen J Henson, Laura Louise Laslett, Steve Simpson-Yap, Suzi B Claflin
BACKGROUND: No large-scale qualitative studies have investigated the lived experience of people living with multiple sclerosis (PwMS) during the pandemic according to their disability level. We used qualitative research methods to investigate the lived experience of a large cohort of Australians living with differing multiple sclerosis (MS)-related disability levels during the COVID-19 pandemic. We also provided useful contextualisation to existing quantitative work. METHODS: This was a retrospective survey-based mixed-methods cohort study...
October 26, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37879899/proximity-extension-assay-based-discovery-of-biomarkers-for-disease-activity-in-chronic-inflammatory-demyelinating-polyneuropathy
#18
JOURNAL ARTICLE
Luuk Wieske, Milou R Michael, Sjors G J G In 't Veld, Allerdien Visser, Ivo N van Schaik, Filip Eftimov, Charlotte E Teunissen
BACKGROUND: Objective disease activity biomarkers are lacking in chronic inflammatory demyelinating polyneuropathy (CIDP), impacting treatment decisions in clinical care and outcomes in clinical trials. Using a proximity extension assay, we aimed to identify candidate serum protein biomarkers for disease activity in CIDP. METHOD: We collected clinical data and serum of 106 patients with CIDP. Patients starting induction treatment (n=53) and patients on maintenance treatment starting treatment withdrawal (n=40) were assessed at baseline and at 6 months (or at relapse)...
October 25, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37879898/clinical-relevance-of-distinguishing-autoimmune-nodopathies-from-cidp-longitudinal-assessment-in-a-large-cohort
#19
JOURNAL ARTICLE
Merel C Broers, Luuk Wieske, Ece Erdag, Cemre Gürlek, Carina Bunschoten, Pieter A van Doorn, Filip Eftimov, Krista Kuitwaard, Juna M de Vries, Marie-Claire Y de Wit, Mariska Mp Nagtzaam, Suzanne C Franken, Louisa Zhu, Manuela Paunovic, Maurice de Wit, Marco Wj Schreurs, Cinta Lleixà, Lorena Martín-Aguilar, Elba Pascual-Goñi, Luis Querol, Bart C Jacobs, Ruth Huizinga, Maarten J Titulaer
BACKGROUND: The aim of this study was to determine treatment response and whether it is associated with antibody titre change in patients with autoimmune nodopathy (AN) previously diagnosed as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and to compare clinical features and treatment response between AN and CIDP. METHODS: Serum IgG antibodies to neurofascin-155 (NF155), contactin-1 (CNTN1) and contactin-associated protein 1 (CASPR1) were detected with cell-based assays in patients diagnosed with CIDP...
October 25, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37879897/are-patients-with-gba-parkinson-disease-good-candidates-for-deep-brain-stimulation-a-longitudinal-multicentric-study-on-a-large-italian-cohort
#20
JOURNAL ARTICLE
Micol Avenali, Roberta Zangaglia, Giada Cuconato, Ilaria Palmieri, Alberto Albanese, Carlo Alberto Artusi, Marco Bozzali, Giovanna Calandra-Buonaura, Francesco Cavallieri, Roberto Cilia, Antoniangela Cocco, Filippo Cogiamanian, Fabiana Colucci, Pietro Cortelli, Alessio Di Fonzo, Roberto Eleopra, Giulia Giannini, Alberto Imarisio, Gabriele Imbalzano, Claudia Ledda, Leonardo Lopiano, Maria Chiara Malaguti, Francesca Mameli, Raffaella Minardi, Pierfrancesco Mitrotti, Edoardo Monfrini, Francesca Spagnolo, Cristina Tassorelli, Francesca Valentino, Franco Valzania, Claudio Pacchetti, Enza Maria Valente
BACKGROUND: GBA variants increase the risk of developing Parkinson disease (PD) and influence its outcome. Deep brain stimulation (DBS) is a recognised therapeutic option for advanced PD. Data on DBS long-term outcome in GBA carriers are scarce. OBJECTIVE: To elucidate the impact of GBA variants on long-term DBS outcome in a large Italian cohort. METHODS: We retrospectively recruited a multicentric Italian DBS-PD cohort and assessed: (1) GBA prevalence; (2) pre-DBS clinical features; and (3) outcomes of motor, cognitive and other non-motor features up to 5 years post-DBS...
October 25, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
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