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Journal of Neurology, Neurosurgery, and Psychiatry

Peter J Goadsby, David W Dodick, James M Martinez, Margaret B Ferguson, Tina M Oakes, Qi Zhang, Vladimir Skljarevski, Sheena K Aurora
BACKGROUND AND OBJECTIVE: As new migraine prevention treatments are developed, the onset of a preventive effect, how long it is maintained and whether patients initially non-responsive develop clinically meaningful responses with continued treatment can be assessed. METHODS: Analyses were conducted post-hoc of a double-blind, placebo-controlled, phase II-a study in patients with episodic migraine receiving galcanezumab 150 mg or placebo biweekly for 12 weeks ( Lancet Neurol 13:885, 2014)...
April 19, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Umaiyal Kugathasan, Matthew R B Evans, Jasper M Morrow, Christopher D J Sinclair, John S Thornton, Tarek A Yousry, Thorsten Hornemann, Saranya Suriyanarayanan, Khadijah Owusu-Ansah, Giuseppe Lauria, Raffaella Lombardi, James M Polke, Emma Wilson, David L H Bennett, Henry Houlden, Michael G Hanna, Julian C Blake, Matilde Laura, Mary M Reilly
OBJECTIVES: Hereditary sensory neuropathy type 1 (HSN1) is a rare, slowly progressive neuropathy causing profound sensory deficits and often severe motor loss. L-serine supplementation is a possible candidate therapy but the lack of responsive outcome measures is a barrier for undertaking clinical trials in HSN1. We performed a 12-month natural history study to characterise the phenotype of HSN1 and to identify responsive outcome measures. METHODS: Assessments included Charcot-Marie-Tooth Neuropathy Score version 2 (CMTNSv2), CMTNSv2-Rasch modified, nerve conduction studies, quantitative sensory testing, intraepidermal nerve fibre density (thigh), computerised myometry (lower limbs), plasma 1-deoxysphingolipid levels, calf-level intramuscular fat accumulation by MRI and patient-based questionnaires (Neuropathic Pain Symptom Inventory and 36-Short Form Health Survey version 2 [SF-36v2])...
April 17, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Georgios Tsivgoulis, Aristeidis H Katsanos, Peter D Schellinger, Martin Köhrmann, Thorsten Steiner, Valeria Caso, Lina Palaiodimou, Daniel Strbian, Niaz Ahmed, Andrei Alexandrov, Sean I Savitz
No abstract text is available yet for this article.
April 17, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Karin Forsberg, Karin Graffmo, Bente Pakkenberg, Markus Weber, Martin Nielsen, Stefan Marklund, Thomas Brännström, Peter Munch Andersen
OBJECTIVE: A hallmark of amyotrophic lateral sclerosis (ALS) caused by mutations in superoxide dismutase-1 ( SOD1 ) are inclusions containing SOD1 in motor neurons. Here, we searched for SOD1-positive inclusions in 29 patients carrying ALS-linked mutations in six other genes. METHODS: A panel of antibodies that specifically recognise misfolded SOD1 species were used for immunohistochemical investigations of autopsy tissue. RESULTS: The 18 patients with hexanucleotide-repeat-expansions in C9orf72 had inclusions of misfolded wild type (WT) SOD1WT in spinal motor neurons...
April 16, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Maximilian I Sprügel, Jochen A Sembill, Joji B Kuramatsu, Stefan T Gerner, Manuel Hagen, Sebastian S Roeder, Matthias Endres, Karl Georg Haeusler, Jan Sobesky, Johannes Schurig, Sarah Zweynert, Miriam Bauer, Peter Vajkoczy, Peter Arthur Ringleb, Jan Christoph Purrucker, Timolaos Rizos, Jens Volkmann, Wolfgang Muellges, Peter Kraft, Anna-Lena Schubert, Frank Erbguth, Martin Nueckel, Peter D Schellinger, Jörg Glahn, Ulrich J Knappe, Gereon Rudolf Fink, Christian Dohmen, Henning Stetefeld, Anna Lena Fisse, Jens Minnerup, Georg Hagemann, Florian Rakers, Heinz Reichmann, Hauke Schneider, Sigrid Wöpking, Albert C Ludolph, Sebastian Stösser, Hermann Neugebauer, Joachim Röther, Peter Michels, Michael Schwarz, Gernot Reimann, Hansjörg Bäzner, Henning Schwert, Joseph Classen, Dominik Michalski, Armin Grau, Frederick Palm, Christian Urbanek, Johannes C Wöhrle, Fahid Alshammari, Markus Horn, Dirk Bahner, Otto W Witte, Albrecht Guenther, Gerhard F Hamann, Hannes Lücking, Arnd Dörfler, Stefan Schwab, Hagen B Huttner
OBJECTIVE: To determine the occurrence of intracranial haemorrhagic complications (IHC) on heparin prophylaxis (low-dose subcutaneous heparin, LDSH) in primary spontaneous intracerebral haemorrhage (ICH) (not oral anticoagulation-associated ICH, non-OAC-ICH), vitamin K antagonist (VKA)-associated ICH and non-vitamin K antagonist oral anticoagulant (NOAC)-associated ICH. METHODS: Retrospective cohort study (RETRACE) of 22 participating centres and prospective single-centre study with 1702 patients with VKA-associated or NOAC-associated ICH and 1022 patients with non-OAC-ICH with heparin prophylaxis between 2006 and 2015...
April 16, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Helmar Christoph Lehmann, David Burke, Satoshi Kuwabara
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated neuropathy typically characterised by symmetrical involvement, and proximal as well as distal muscle weakness (typical CIDP). However, there are several 'atypical' subtypes, such as multifocal acquired demyelinating sensory and motor neuropathy (Lewis-Sumner syndrome) and 'distal acquired demyelinating symmetric neuropathy', possibly having different immunopathogenesis and treatment responses. In the absence of diagnostic and pathogenetic biomarkers, diagnosis and treatment may be difficult, but recent progress has been made in the application of neuroimaging tools demonstrating nerve hypertrophy and in identifying subgroups of patients who harbour antibodies against nodal proteins such as neurofascin and contactin-1...
April 16, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Martha S Foiani, Claudia Cicognola, Natalia Ermann, Ione O C Woollacott, Carolin Heller, Amanda J Heslegrave, Ashvini Keshavan, Ross W Paterson, Keqiang Ye, Johannes Kornhuber, Nick C Fox, Jonathan M Schott, Jason D Warren, Piotr Lewczuk, Henrik Zetterberg, Kaj Blennow, Kina Höglund, Jonathan D Rohrer
BACKGROUND: Frontotemporal dementia (FTD) is a pathologically heterogeneous neurodegenerative disorder associated usually with tau or TDP-43 pathology, although some phenotypes such as logopenic variant primary progressive aphasia are more commonly associated with Alzheimer's disease pathology. Currently, there are no biomarkers able to diagnose the underlying pathology during life. In this study, we aimed to investigate the potential of novel tau species within cerebrospinal fluid (CSF) as biomarkers for tau pathology in FTD...
April 13, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Océane Landon-Cardinal, Laure Gallay, Odile Dubourg, Thierry Maisonobe, Sarah Léonard-Louis, Dalila Beniken, Anne Simon, Anthony Behin, Tanya Stojkovic, Charles Duyckaerts, Guillaume Breton, Aude Rigolet, Olivier Fain, Marie-Caroline Meyohas, Catherine Leport, Marc-Antoine Valantin, Daniel Vittecoq, Jean-François Bergmann, Thomas Hanslik, Marie-Paule Chauveheid, Zahir Amoura, Thomas de Broucker, Bruno Eymard, Nausicaa Beaudequin, Olivier Benveniste, Yves Allenbach
No abstract text is available yet for this article.
April 11, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Ruben P A van Eijk, James Rooney, Orla Hardiman, Leonard H van den Berg
No abstract text is available yet for this article.
April 11, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Noriko Isobe
No abstract text is available yet for this article.
April 10, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Lorenzo Gaetani, Kaj Blennow, Paolo Calabresi, Massimiliano Di Filippo, Lucilla Parnetti, Henrik Zetterberg
In the management of neurological diseases, the identification and quantification of axonal damage could allow for the improvement of diagnostic accuracy and prognostic assessment. Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal damage in a variety of neurological disorders, including inflammatory, neurodegenerative, traumatic and cerebrovascular diseases...
April 9, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Sara Mariotto, Sergio Ferrari, Matteo Gastaldi, Diego Franciotta, Elia Sechi, Ruggero Capra, Chiara Mancinelli, Kathrin Schanda, Daniela Alberti, Riccardo Orlandi, Roberto Bombardi, Luigi Zuliani, Marco Zoccarato, Maria Donata Benedetti, Raffaella Tanel, Francesca Calabria, Francesca Rossi, Antonino Pavone, Luisa Grazian, GianPietro Sechi, Lucia Batzu, Noemi Murdeu, Francesco Janes, Vincenza Fetoni, Daniela Fulitano, Gianola Stenta, Lisa Federle, Gaetano Cantalupo, Markus Reindl, Salvatore Monaco, Alberto Gajofatto
No abstract text is available yet for this article.
April 5, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Elodie Hainque, Domitille Gras, Aurélie Meneret, Mariana Atencio, Marie-Pierre Luton, Magali Barbier, Mohamed Doulazmi, Florence Habarou, Chris Ottolenghi, Emmanuel Roze, Fanny Mochel
No abstract text is available yet for this article.
April 4, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Wallace J Brownlee, Bhavana Solanky, Ferran Prados, Marios Yiannakas, Patricia Da Mota, Frank Riemer, Manuel Jorge Cardoso, Sebastian Ourselin, Xavier Golay, Claudia Gandini Wheeler-Kingshott, Olga Ciccarelli
OBJECTIVE: Sodium (23 Na)-MRI is an emerging imaging technique to investigate in vivo changes in tissue viability, reflecting neuroaxonal integrity and metabolism. Using an optimised 23 Na-MRI protocol with smaller voxel sizes and improved tissue contrast, we wanted to investigate whether brain total sodium concentration (TSC) is a biomarker for long-term disease outcomes in a cohort of patients with relapse-onset multiple sclerosis (MS), followed from disease onset. METHODS: We performed a cross-sectional study in 96 patients followed up ~ 15 years after a clinically isolated syndrome (CIS) and 34 healthy controls...
April 4, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Emma Foster, Patrick Carney, Danny Liew, Zanfina Ademi, Terry O'Brien, Patrick Kwan
Almost 10% of people will experience at least one seizure over a lifetime. Although common, first seizures are serious events and warrant careful assessment and management. First seizures may be provoked by acute or remote symptomatic factors including life-threatening metabolic derangements, drug toxicity or structural brain lesions. An unprovoked first seizure may herald the onset of epilepsy and may be accompanied by medical and psychiatric illnesses. Accidents, injuries and death associated with first seizures are likely under-reported...
April 4, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Kim Chivers Seymour, Ruth Pickering, Lynn Rochester, Helen C Roberts, Claire Ballinger, Sophia Hulbert, Dorit Kunkel, Ioana R Marian, Carolyn Fitton, Emma McIntosh, Victoria A Goodwin, Alice Nieuwboer, Sarah E Lamb, Ann Ashburn
OBJECTIVE: To estimate the effect of a physiotherapist-delivered fall prevention programme for people with Parkinson's (PwP). METHODS: People at risk of falls with confirmed Parkinson's were recruited to this multicentre, pragmatic, investigator blind, individually randomised controlled trial with prespecified subgroup analyses. 474 PwP (Hoehn and Yahr 1-4) were randomised: 238 allocated to a physiotherapy programme and 236 to control. All participants had routine care; the control group received a DVD about Parkinson's and single advice session at trial completion...
April 3, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Steve Vucic
No abstract text is available yet for this article.
March 25, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Rocío Fernández-Méndez, Hugh K Richards, Helen M Seeley, John D Pickard, Alexis J Joannides
OBJECTIVES: To determine current epidemiology and clinical characteristics of cerebrospinal fluid (CSF) shunt surgery, including revisions. METHODS: A retrospective, multicentre, registry-based study was conducted based on 10 years' data from the UK Shunt Registry, including primary and revision shunting procedures reported between 2004 and 2013. Incidence rates of primary shunts, descriptive statistics and shunt revision rates were calculated stratified by age group, geographical region and year of operation...
March 25, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Seol-Hee Baek, Yoon-Ho Hong, Seok-Jin Choi, So Hyun Ahn, Kee Hong Park, Je-Young Shin, Jung-Joon Sung
OBJECTIVE: This study aimed to explore the correlations between electrodiagnostic (EDX) features in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and to investigate whether EDX data-driven clustering can identify a distinct subgroup regarding clinical phenotype and treatment response. METHODS: We reviewed clinical and EDX data of 56 patients with definite CIDP fulfilling the 2010 European Federation of Neurological Societies and Peripheral Nerve Society criteria at two teaching hospitals...
March 23, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Edwin Jabbari, John Woodside, Tong Guo, Nadia K Magdalinou, Viorica Chelban, Dilan Athauda, Andrew J Lees, Thomas Foltynie, Henry Houlden, Alistair Church, Michele Tm Hu, James B Rowe, Henrik Zetterberg, Huw R Morris
OBJECTIVE: The high degree of clinical overlap between atypical parkinsonian syndromes (APS) and Parkinson's disease (PD) makes diagnosis challenging. We aimed to identify novel diagnostic protein biomarkers of APS using multiplex proximity extension assay (PEA) testing. METHODS: Cerebrospinal fluid (CSF) samples from two independent cohorts, each consisting of APS and PD cases, and controls, were analysed for neurofilament light chain (NF-L) and Olink Neurology and Inflammation PEA biomarker panels...
March 13, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
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