journal
Journals Journal of Neurology, Neurosur...

Journal of Neurology, Neurosurgery, and Psychiatry

https://read.qxmd.com/read/38760152/nigrostriatal-blood-brain-barrier-opening-in-parkinson-s-disease
#1
JOURNAL ARTICLE
Carmen Gasca-Salas, José A Pineda-Pardo, Marta Del Álamo, Tamara Jiménez, Clara Trompeta, Gabriella Toltsis, Lina Garcia-Cañamaque, Beatriz Fernández-Rodríguez, Michele Matarazzo, Isabel Plaza de Las Heras, Elena Natera-Villalba, Raúl Martínez-Fernández, Alicia Duque, Santiago Ruiz de Aguiar, Javier Blesa, Itay Rachmilevich, José A Obeso
BACKGROUND: The nigrostriatal system is especially vulnerable to neurodegeneration in Parkinson's disease (PD) and the blood-brain barrier (BBB) is a limiting factor for delivery of therapeutic agents to the brain. This pilot study aimed to demonstrate safety, feasibility and tissue penetration (by 18F-Choline-positron emission tomography (PET)) of MR-guided focused ultrasound (MRgFUS) simultaneous BBB opening (BBB-O) in the substantia nigra (SN) and putamen in PD. METHODS: Three patients underwent MRgFUS for midbrain and putamen BBB-O...
May 17, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38754979/cognitive-rehabilitation-effects-on-grey-matter-volume-and-go-nogo-activity-in-progressive-multiple-sclerosis-results-from-the-cogex-trial
#2
JOURNAL ARTICLE
Maria A Rocca, Paola Valsasina, Francesco Romanò, Nicolò Tedone, Maria Pia Amato, Giampaolo Brichetto, Vincenzo Daniele Boccia, Jeremy Chataway, Nancy D Chiaravalloti, Gary Cutter, Ulrik Dalgas, John DeLuca, Rachel A Farrell, Peter Feys, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Robert W Motl, Amber Salter, Brian M Sandroff, Anthony Feinstein, Massimo Filippi
BACKGROUND: Research on cognitive rehabilitation (CR) and aerobic exercise (EX) to improve cognition in progressive multiple sclerosis (PMS) remains limited. CogEx trial investigated the effectiveness of CR and EX in PMS: here, we present MRI substudy volumetric and task-related functional MRI (fMRI) findings. METHODS: Participants were randomised to: 'CR plus EX', 'CR plus sham EX (EX-S)', 'EX plus sham CR (CR-S)' and 'CR-S plus EX-S' and attended 12-week intervention...
May 16, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38749674/implications-for-driving-based-on-the-risk-of-seizures-after-ischaemic-stroke
#3
JOURNAL ARTICLE
Kai Michael Schubert, Giulio Bicciato, Lucia Sinka, Laura Abraira, Estevo Santamarina, José Álvarez-Sabín, Carolina Ferreira-Atuesta, Mira Katan, Natalie Scherrer, Robert Terziev, Nico Döhler, Barbara Erdélyi-Canavese, Ansgar Felbecker, Philip Siebel, Michael Winklehner, Tim J von Oertzen, Judith N Wagner, Gian Luigi Gigli, Annacarmen Nilo, Francesco Janes, Giovanni Merlino, Mariarosaria Valente, María Paula Zafra-Sierra, Luis Carlos Mayor-Romero, Julian Conrad, S Evers, Piergiorgio Lochner, Frauke Roell, Francesco Brigo, Carla Bentes, Rita Peralta, Teresa Pinho E Melo, Mark R Keezer, John Sidney Duncan, Josemir W Sander, Barbara Tettenborn, Matthias Koepp, Marian Galovic
BACKGROUND: In addition to other stroke-related deficits, the risk of seizures may impact driving ability after stroke. METHODS: We analysed data from a multicentre international cohort, including 4452 adults with acute ischaemic stroke and no prior seizures. We calculated the Chance of Occurrence of Seizure in the next Year (COSY) according to the SeLECT2.0 prognostic model. We considered COSY<20% safe for private and <2% for professional driving, aligning with commonly used cut-offs...
May 15, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38749673/implications-for-driving-based-on-the-risk-of-seizures-after-ischaemic-stroke
#4
EDITORIAL
Nishant K Mishra
No abstract text is available yet for this article.
May 15, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38744462/genetics-of-inherited-peripheral-neuropathies-and-the-next-frontier-looking-backwards-to-progress-forwards
#5
REVIEW
Jevin M Parmar, Nigel G Laing, Marina L Kennerson, Gianina Ravenscroft
Inherited peripheral neuropathies (IPNs) encompass a clinically and genetically heterogeneous group of disorders causing length-dependent degeneration of peripheral autonomic, motor and/or sensory nerves. Despite gold-standard diagnostic testing for pathogenic variants in over 100 known associated genes, many patients with IPN remain genetically unsolved. Providing patients with a diagnosis is critical for reducing their 'diagnostic odyssey', improving clinical care, and for informed genetic counselling. The last decade of massively parallel sequencing technologies has seen a rapid increase in the number of newly described IPN-associated gene variants contributing to IPN pathogenesis...
May 14, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38744461/highlighting-the-past-and-future-of-inherited-peripheral-neuropathies
#6
EDITORIAL
Stephan Zuchner
No abstract text is available yet for this article.
May 14, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38744460/trajectories-of-self-reported-fatigue-following-initiation-of-multiple-sclerosis-disease-modifying-therapy
#7
JOURNAL ARTICLE
Simon Englund, Thomas Frisell, Ying Qu, Kavita Gandhi, Annika Hultén, Marie Kierkegaard, Fredrik Piehl, Elisa Longinetti
BACKGROUND: We analysed the COMparison Between All immunoTherapies for Multiple Sclerosis (NCT03193866), a Swedish nationwide observational study in relapsing-remitting multiple sclerosis (RRMS), to identify trajectories of fatigue and their association with physical disability following start of disease-modifying therapy (DMT). METHODS: Using a group-modelling approach, we assessed trajectories of fatigue with the Fatigue Scale for Motor and Cognitive Functions and physical disability with Expanded Disability Status Scale among 1587 and 1818 individuals who initiated a first DMT and had a first DMT switch, respectively, followed during 2011-2022...
May 14, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38744459/oral-corticosteroid-dosage-and-tapeduration-at-onset-in-myelin-oligodendrocyte-glycoprotein-antibody-associated-disease-influences-time-to-first-relapse
#8
JOURNAL ARTICLE
Benjamin P Trewin, Russell C Dale, Jessica Qiu, Melissa Chu, Niroshan Jeyakumar, Fionna Dela Cruz, Jane Andersen, Pakeeran Siriratnam, Kit Kwan M Ma, Todd A Hardy, Anneke van der Walt, Jeanette Lechner-Scott, Helmut Butzkueven, Simon A Broadley, Michael H Barnett, Stephen W Reddel, Fabienne Brilot, Tomas Kalincik, Sudarshini Ramanathan
BACKGROUND: We sought to identify an optimal oral corticosteroid regimen at the onset of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), which would delay time to first relapse while minimising cumulative corticosteroid exposure. METHODS: In a retrospective multicentre cohort study, Cox proportional hazards models examined the relationship between corticosteroid course as a time-varying covariate and time to first relapse. Simon-Makuch and Kaplan-Meier plots identified an optimal dosing strategy...
May 14, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38744458/impact-of-previous-treatment-history-and-b-cell-depletion-treatment-duration-on-infection-risk-in-relapsing-remitting-multiple-sclerosis-a-nationwide-cohort-study
#9
JOURNAL ARTICLE
Suvi Virtanen, Fredrik Piehl, Thomas Frisell
BACKGROUND: B-cell depletion displays striking effectiveness in relapsing-remitting multiple sclerosis (RRMS), but is also associated with increased infection risk. To what degree previous treatment history, disease-modifying therapy (DMT) switching pattern and time on treatment modulate this risk is unknown. The objective here was to evaluate previous DMT use and treatment duration as predictors of infection risk with B-cell depletion. METHODS: We conducted a nationwide RRMS cohort study leveraging data from the Swedish MS registry and national demographic and health registries recording all outpatient-treated and inpatient-treated infections and antibiotics prescriptions from 1 January 2012 to 30 June 2021...
May 14, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38729747/efficacy-safety-and-tolerability-of-rozanolixizumab-in-patients-with-chronic-inflammatory-demyelinating-polyradiculoneuropathy-a-randomised-subject-blind-investigator-blind-placebo-controlled-phase-2a-trial-and-open-label-extension-study
#10
JOURNAL ARTICLE
Luis Querol, Jérôme De Sèze, Tina Dysgaard, Todd Levine, T Hemanth Rao, Michael Rivner, Hans-Peter Hartung, Peter Kiessling, Saori Shimizu, Dominika Marmol, Ali Bozorg, Anny-Odile Colson, Ute Massow, Filip Eftimov
BACKGROUND: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a peripheral nerve disorder characterised by weakness and sensory loss. We assessed the neonatal Fc receptor inhibitor rozanolixizumab for CIDP management. METHODS: CIDP01 (NCT03861481) was a randomised, subject-blind, investigator-blind, placebo-controlled, phase 2a study. Adults with definite or probable CIDP receiving subcutaneous or intravenous immunoglobulin maintenance therapy were randomised 1:1 to 12 once-weekly subcutaneous infusions of rozanolixizumab 10 mg/kg or placebo, stratified according to previous immunoglobulin administration route...
May 10, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38729746/prospective-open-label-trial-with-rituximab-in-patients-with-chronic-inflammatory-demyelinating-polyradiculoneuropathy-not-responding-to-conventional-immune-therapies
#11
JOURNAL ARTICLE
Pietro Emiliano Doneddu, Dario Cocito, Raffaella Fazio, Luana Benedetti, Erdita Peci, Giuseppe Liberatore, Yuri Matteo Falzone, Francesco Germano, Francesca Gallia, Claudia Giannotta, Cinta Lleixà, Elisa Bianchi, Eduardo Nobile-Orazio
BACKGROUND: To evaluate the efficacy of rituximab in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) patients not responding to conventional immune therapies. METHODS: An open-label, prospective exploratory study was conducted with intravenous rituximab on 17 CIDP patients who had not responded to at least two first-line therapies. The primary endpoint was to determine the proportion of patients who showed improvement 6 months after rituximab therapy...
May 10, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38729745/cidp-trials-and-tribulations
#12
EDITORIAL
Simon Rinaldi
No abstract text is available yet for this article.
May 10, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38724232/phase-1-study-of-safety-and-preliminary-efficacy-of-intranasal-transplantation-of-human-neural-stem-cells-ange-s003-in-parkinson-s-disease
#13
JOURNAL ARTICLE
Shenzhong Jiang, Han Wang, Chengxian Yang, Feng Feng, Dan Xu, Mengyu Zhang, Manqing Xie, Ruixue Cui, Zhaohui Zhu, Chenhao Jia, Linwen Liu, Lin Wang, Xunzhe Yang, Yingmai Yang, Honglin Hao, Zhaoxi Liu, Zhihong Wu, Ling Leng, Xiaoxin Li, Xicai Sun, Xiongfei Zhao, Jinfang Xu, Yi Zhang, Xinhua Wan, Xinjie Bao, Renzhi Wang
BACKGROUND: Intranasal transplantation of ANGE-S003 human neural stem cells showed therapeutic effects and were safe in preclinical models of Parkinson's disease (PD). We investigated the safety and tolerability of this treatment in patients with PD and whether these effects would be apparent in a clinical trial. METHODS: This was a 12-month, single-centre, open-label, dose-escalation phase 1 study of 18 patients with advanced PD assigned to four-time intranasal transplantation of 1 of 3 doses: 1...
May 9, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38724231/neurophysiological-features-of-stn-lfp-underlying-sleep-fragmentation-in-parkinson-s-disease
#14
JOURNAL ARTICLE
Guokun Zhang, Huiling Yu, Yue Chen, Chen Gong, Hongwei Hao, Yi Guo, Shujun Xu, Yuhuan Zhang, Xuemei Yuan, Guoping Yin, Jian-Guo Zhang, Huiling Tan, Luming Li
BACKGROUND: Sleep fragmentation is a persistent problem throughout the course of Parkinson's disease (PD). However, the related neurophysiological patterns and the underlying mechanisms remained unclear. METHOD: We recorded subthalamic nucleus (STN) local field potentials (LFPs) using deep brain stimulation (DBS) with real-time wireless recording capacity from 13 patients with PD undergoing a one-night polysomnography recording, 1 month after DBS surgery before initial programming and when the patients were off-medication...
May 9, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38719433/active-and-non-active-progression-independent-of-relapse-activity-within-the-first-20-years-of-relapsing-multiple-sclerosis
#15
JOURNAL ARTICLE
Adil Maarouf, Jan Patrick Stellmann, Audrey Rico, Clemence Boutiere, Sarah Demortiere, Pierre Durozard, Wafaa Zaaraoui, Jean-Philippe Ranjeva, Jean Pelletier, Bertrand Audoin
BACKGROUND: Progression independent of relapse activity (PIRA) has been described since the early stage of relapsing multiple sclerosis (RMS). However, little is known about the relation between PIRA and inflammatory activity that is particularly important at this stage of the disease. METHOD: We included 110 patients in a prospective study within 18 months of RMS onset. MRI examinations and clinical visits were scheduled on the same day for months 0, 6, 12, 24, 36, 60, 84, 120, 180 and 240...
May 6, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38719432/a-phase-i-trial-of-accelerated-intermittent-theta-burst-rtms-for-amnestic-mci
#16
JOURNAL ARTICLE
Stephanie Aghamoosa, James Lopez, Katrina Rbeiz, Holly H Fleischmann, Olivia Horn, Katrina Madden, Kevin A Caulfield, Michael U Antonucci, Gonzalo Revuelta, Lisa M McTeague, Andreana Benitez
BACKGROUND: Emerging evidence suggests that repetitive transcranial magnetic stimulation (rTMS) enhances cognition in mild cognitive impairment (MCI). Accelerated intermittent theta burst stimulation (iTBS) rTMS protocols are promising as they substantially reduce burden by shortening the treatment course, but the safety, feasibility, and acceptability of iTBS have not been established in MCI. METHODS: 24 older adults with amnestic MCI (aMCI) due to possible Alzheimer's disease enrolled in a phase I trial of open-label accelerated iTBS to the left dorsolateral prefrontal cortex (8 stimulation sessions of 600 pulses of iTBS/day for 3 days)...
May 6, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38670790/weighing-the-impact-of-post-hoc-studies
#17
EDITORIAL
Karen L Furie
No abstract text is available yet for this article.
April 26, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38670789/does-stereotactic-thrombolysis-with-alteplase-for-intracerebral-haemorrhage-alter-intraventricular-haematoma-volume-a-secondary-analysis-of-the-mistie-iii-trial
#18
JOURNAL ARTICLE
Philip Sun, Shervin Badihian, Radhika Avadhani, Nathan Walborn, Anusha Yarava, Donya Alimoradi, Issam Awad, Daniel Hanley, Santosh Murthy, Wendy Ziai
BACKGROUND: Stereotactic thrombolysis reduces intracerebral haemorrhage (ICH) volume in patients with spontaneous ICH. Whether intrahaematomal alteplase administration is associated with a change in intraventricular haemorrhage volume (deltaIVH) and functional outcomes is unknown. METHODS: Post hoc secondary analysis of the Minimally Invasive Surgery plus Alteplase for Intracerebral Hemorrhage Evacuation Phase III (MISTIE-III) trial in patients with IVH on the stability CT scan...
April 26, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38663995/identification-of-dagla-as-an-autoantibody-target-in-cerebellar-ataxia
#19
JOURNAL ARTICLE
Ramona Miske, Madeleine Scharf, Kathrin Borowski, Ina Specht, Merle Corty, Monika-Johanna Loritz, Frederik Rombach, Guy Laureys, Nadine Rochow, Christiane Radzimski, Linda Schnitter, Dominica Ratuszny, Thomas Skripuletz, Mike P Wattjes, Stefanie Hahn, Yvonne Denno, Khadija Guerti, Matthijs Oyaert, Farid Benkhadra, Corinna Ines Bien, Sophie Nitsch, Klaus-Peter Wandinger, Vincent van Pesch, Christian Probst, Bianca Teegen, Lars Komorowski, Kurt-Wolfram Sühs
BACKGROUND: We aimed to investigate the clinical, imaging and fluid biomarker characteristics in patients with antidiacylglycerol lipase alpha (DAGLA)-autoantibody-associated cerebellitis. METHODS: Serum and cerebrospinal fliud (CSF) samples from four index patients were subjected to comprehensive autoantibody screening by indirect immunofluorescence assay (IIFA). Immunoprecipitation, mass spectrometry and recombinant protein assays were used to identify the autoantigen...
April 25, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38663994/genetics-impact-risk-of-alzheimer-s-disease-through-mechanisms-modulating-structural-brain-morphology-in-late-life
#20
JOURNAL ARTICLE
Roxanna Korologou-Linden, Bing Xu, Elizabeth Coulthard, Esther Walton, Alfie Wearn, Gibran Hemani, Tonya White, Charlotte Cecil, Tamsin Sharp, Henning Tiemeier, Tobias Banaschewski, Arun Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sabina Millenet, Juliane H Fröhner, Michael Smolka, Henrik Walter, Jeanne Winterer, Robert Whelan, Gunter Schumann, Laura D Howe, Yoav Ben-Shlomo, Neil M Davies, Emma Louise Anderson
BACKGROUND: Alzheimer's disease (AD)-related neuropathological changes can occur decades before clinical symptoms. We aimed to investigate whether neurodevelopment and/or neurodegeneration affects the risk of AD, through reducing structural brain reserve and/or increasing brain atrophy, respectively. METHODS: We used bidirectional two-sample Mendelian randomisation to estimate the effects between genetic liability to AD and global and regional cortical thickness, estimated total intracranial volume, volume of subcortical structures and total white matter in 37 680 participants aged 8-81 years across 5 independent cohorts (Adolescent Brain Cognitive Development, Generation R, IMAGEN, Avon Longitudinal Study of Parents and Children and UK Biobank)...
April 25, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
journal
journal
20159
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.