journal
https://read.qxmd.com/read/38839636/alternating-hemidystonia-of-childhood-a-unique-presentation-of-atp1a3-treated-with-trihexyphenidyl
#21
LETTER
Jonathan Bundy, Hongfei Zhao, Yasaman Kianirad
No abstract text is available yet for this article.
June 5, 2024: Journal of Neurology
https://read.qxmd.com/read/38836907/rituximab-alone-is-as-effective-as-associated-with-steroids-on-naive-patients-with-generalized-myasthenia-gravis
#22
JOURNAL ARTICLE
Charlotte Héraud, Saskia Bresch, Cassandre Landes-Château, Véronique Bourg, Christine Lebrun-Frenay
INTRODUCTION: Rituximab (RTX) has been proven effective in managing refractory generalized myasthenia gravis (MG), and its use is increasing worldwide. MG stabilization may initially require oral corticosteroid (CS) therapy, but its long-term side effects require the shortest duration of treatment. We studied the clinical effectiveness and usefulness of corticosteroids associated with RTX compared to RTX alone on MG remission. METHODS: In a monocentric retrospective cohort in the Nice University Hospital, we compared naïve MG patients treated with RTX as first-line therapy alone (G1) or associated with CS (G2)...
June 5, 2024: Journal of Neurology
https://read.qxmd.com/read/38836906/association-between-procedural-time-and-outcome-in-unsuccessful-mechanical-thrombectomy-for-acute-ischemic-stroke-analysis-from-the-italian-registry-of-endovascular-treatment-in-acute-stroke
#23
JOURNAL ARTICLE
Fabrizio Sallustio, Ettore Nicolini, Valentina Saia, Giovanni Pracucci, Alfredo Paolo Mascolo, Federico Marrama, Roberto Gandini, Valerio Da Ros, Marina Diomedi, Fana Alemseged, Ilaria Casetta, Enrico Fainardi, Lucio Castellan, Massimo Del Sette, Nicola Limbucci, Patrizia Nencini, Mauro Bergui, Paolo Cerrato, Andrea Saletti, Alessandro De Vito, Samuele Cioni, Rossana Tassi, Luigi Simonetti, Andrea Zini, Maria Ruggiero, Marco Longoni, Agostino Tessitore, Ludovica Ferraù, Nicola Cavasin, Adriana Critelli, Stefano Vallone, Guido Bigliardi, Domenico Sergio Zimatore, Marco Petruzzellis, Andrea Boghi, Andrea Naldi, Alessio Comai, Elisa Dall'Ora, Giuseppina Sanfilippo, Alessandra Persico, Ivan Gallesio, Federica Sepe, Roberto Menozzi, Alessandro Pezzini, Michele Besana, Alessia Giossi, Antioco Sanna, Tiziana Tassinari, Nicola Burdi, Giovanni Boero, Raffaele Augelli, Manuel Cappellari, Mirco Cosottini, Nicola Giannini, Daniele G Romano, Giulia Frauenfelder, Paolo Nunzio Nuzzi, Maria Carmela Spinelli, Adriana Paladini, Annalisa Rizzo, Marco Filizzolo, Marina Mannino, Carmine Timpani, Federica De Santis, Giuseppe Carità, Monia Russo, Gianluca Galvano, Luigi Sicurella, Salvatore Mangiafico, Danilo Toni
BACKGROUND: We aim to assess the association between procedural time and outcomes in patients in unsuccessful mechanical thrombectomy (MT) for anterior circulation acute stroke. METHODS: We conducted a cohort study on prospectively collected data from patients with M1 and/or M2 segment of middle cerebral artery occlusion with a thrombolysis in cerebral infarction 0-1 at the end of procedure. Primary outcome was 90-day poor outcome. Secondary outcomes were early neurological deterioration (END), symptomatic intracranial hemorrhage (sICH) according to ECASS II and sICH according to SITS-MOST...
June 5, 2024: Journal of Neurology
https://read.qxmd.com/read/38834701/automated-detection-of-cognitive-impairment-in-clinical-practice
#24
JOURNAL ARTICLE
Robyn M Busch, Olivia Hogue, Abagail F Postle, Darlene P Floden
OBJECTIVE: Cognitive impairment is now recognized as an impending public health crisis. About one-third of adults are concerned about their cognition, and the prevalence of objective cognitive impairment is much higher among those with neurological disorders. Existing screening tools are narrowly focused on detecting dementia in older adults and must be clinician-administered and scored, making them impractical for many neurology practices. This study examined the utility of a brief, self-administered, computerized cognitive screening tool, the Brief Assessment of Cognitive Health (BACH), in identifying cognitive impairment in adults...
June 4, 2024: Journal of Neurology
https://read.qxmd.com/read/38834700/the-effect-of-exercise-on-balance-function-in-stroke-patients-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#25
REVIEW
Yilun Zhou, Hao Ren, Xiao Hou, Xiaosheng Dong, Shiyan Zhang, Yuanyuan Lv, Cui Li, Laikang Yu
OBJECTIVE: A growing body of studies has examined the effect of exercise on balance function in stroke patients, with conflicting findings. This study aimed to investigate the effect of exercise on balance function in stroke patients and to determine the optimal exercise prescription for stroke patients. METHODS: We conducted an extensive search across various databases, including PubMed, Web of Science, EBSCO, Cochrane, and Scopus. The search was conducted until March 11th, 2024...
June 4, 2024: Journal of Neurology
https://read.qxmd.com/read/38831109/falsely-reassuring-impedance-in-a-patient-with-deep-brain-stimulation-a-case-report
#26
LETTER
A Dib, G Polo, T Danaila, C Laurencin, S Prange, S Thobois
No abstract text is available yet for this article.
June 3, 2024: Journal of Neurology
https://read.qxmd.com/read/38829431/long-term-treatment-of-sod1-als-with-tofersen-a-multicentre-experience-in-17-patients
#27
JOURNAL ARTICLE
Mario Sabatelli, Federica Cerri, Riccardo Zuccarino, Agata Katia Patanella, Daniela Bernardo, Giulia Bisogni, Raffaella Tanel, Valeria Sansone, Massimiliano Filosto, Serena Lattante, Francesco Martello, Paolo Niccolò Doronzio, Salvatore Stano, Bruno Antonio Zanfini, Michela Coccia, Emanuele Maria Costantini, Andrea Lizio, Gabriele Lucioli, Alessandro Padovani, Gian Paolo Merlini, Amelia Conte
BACKGROUND: In Amyotrophic Lateral Sclerosis (ALS) patients with SOD1 mutation the intrathecal administration of tofersen slowed down the progression of disease in a controlled clinical study, but results were not statistically significant. METHODS: In this multicentre, observational study, we evaluated a cohort of 27 ALS-SOD1 patients who were treated with tofersen, focussing on 17 patients who were followed for at least 48 weeks (median period of 84 weeks, range 48-108)...
June 3, 2024: Journal of Neurology
https://read.qxmd.com/read/38824491/change-in-cognitive-performance-during-seven-year-follow-up-in-midlife-is-associated-with-sex-age-and-education-the-cardiovascular-risk-in-young-finns-study
#28
JOURNAL ARTICLE
Marja A Heiskanen, Jaakko Nevalainen, Katja Pahkala, Markus Juonala, Nina Hutri, Mika Kähönen, Eero Jokinen, Tomi P Laitinen, Päivi Tossavainen, Leena Taittonen, Jorma S A Viikari, Olli T Raitakari, Suvi P Rovio
OBJECTIVE: Sex, age, and education are associated with the level of cognitive performance. We investigated whether these factors modulate the change in cognitive performance in midlife by leveraging the longitudinal data from the Cardiovascular Risk in Young Finns Study (YFS). METHODS: Participants of the YFS cohort performed a computer-based Cambridge Neuropsychological Test Automated Battery (CANTAB) in 2011 and 2018 (n = 1671, age 41-56 years in 2018)...
June 2, 2024: Journal of Neurology
https://read.qxmd.com/read/38822840/sara-captures-disparate-progression-and-responsiveness-in-spinocerebellar-ataxias
#29
JOURNAL ARTICLE
Emilien Petit, Tanja Schmitz-Hübsch, Giulia Coarelli, Heike Jacobi, Anna Heinzmann, Karla P Figueroa, Susan L Perlman, Christopher M Gomez, George R Wilmot, Jeremy D Schmahmann, Sarah H Ying, Theresa A Zesiewicz, Henry L Paulson, Vikram G Shakkottai, Khalaf O Bushara, Sheng-Han Kuo, Michael D Geschwind, Guangbin Xia, Stefan M Pulst, S H Subramony, Claire Ewenczyk, Alexis Brice, Alexandra Durr, Thomas Klockgether, Tetsuo Ashizawa, Sophie Tezenas du Montcel
BACKGROUND: The Scale for Assessment and Rating of Ataxia (SARA) is a widely used clinical scale to assess cerebellar ataxia but faces some criticisms about the relevancy of all its items. OBJECTIVES: To prepare for future clinical trials, we analyzed the progression of SARA and its items in several polyQ spinocerebellar ataxias (SCA) from various cohorts. METHODS: We included data from patients with SCA1, SCA2, SCA3, and SCA6 from four cohorts (EUROSCA, RISCA, CRC-SCA, and SPATAX) for a total of 850 carriers and 3431 observations...
June 1, 2024: Journal of Neurology
https://read.qxmd.com/read/38822839/status-epilepticus-in-polg-disease-a-large-multinational-study
#30
JOURNAL ARTICLE
Omar Hikmat, Karin Naess, Martin Engvall, Claus Klingenberg, Magnhild Rasmussen, Eylert Brodtkorb, Elsebet Ostergaard, Irenaeus de Coo, Leticia Pias-Peleteiro, Pirjo Isohanni, Johanna Uusimaa, Kari Majamaa, Mikko Kärppä, Juan Dario Ortigoza-Escobar, Trine Tangeraas, Siren Berland, Emma Harrison, Heather Biggs, Rita Horvath, Niklas Darin, Shamima Rahman, Laurence A Bindoff
We aimed to provide a detailed phenotypic description of status epilepticus (SE) in a large cohort of patients with POLG disease and identify prognostic biomarkers to improve the management of this life-threatening condition. In a multinational, retrospective study with data on patients with POLG disease from seven European countries, we identified those who had SE. The age of SE onset, accompanying clinical, laboratory, imaging and genetic findings were analysed. One hundred and ninety-five patients with genetically confirmed POLG disease were recruited, of whom 67% (130/194) had epilepsy...
June 1, 2024: Journal of Neurology
https://read.qxmd.com/read/38822148/alice-in-wonderland-syndrome-aiws-prevalence-and-characteristics-in-adults-with-migraine
#31
JOURNAL ARTICLE
Mira P Fitzek, Jasper Mecklenburg, Lucas H Overeem, Kristin S Lange, Anke Siebert, Paul Triller, Lars Neeb, Jens P Dreier, Daniel Kondziella, Uwe Reuter, Bianca Raffaelli
OBJECTIVE: Alice in Wonderland Syndrome (AIWS) is a sensory disorder characterized by a distorted somatosensory and/or visual perception. Additionally, distortion of time perception and symptoms of derealization/depersonalization may occur. AIWS is frequently associated with migraine. However, its prevalence, and clinical characteristics remain poorly understood. Here, we investigated the prevalence and features of AIWS in individuals with migraine. We hypothesized AIWS is more frequent in migraine patients with aura than in those without aura...
May 31, 2024: Journal of Neurology
https://read.qxmd.com/read/38822147/motor-and-non-motor-outcome-in-tremor-dominant-parkinson-s-disease-after-mr-guided-focused-ultrasound-thalamotomy
#32
JOURNAL ARTICLE
Veronika Purrer, Emily Pohl, Valeri Borger, Hannah Weiland, Henning Boecker, Frederic Carsten Schmeel, Ullrich Wüllner
BACKGROUND AND OBJECTIVES: Magnetic Resonance-guided Focused Ultrasound (MRgFUS) is an emerging technique for the treatment of severe, medication-refractory tremor syndromes. We here report motor and non-motor outcomes 6 and 12 months after unilateral MRgFUS thalamotomy in tremor-dominant Parkinson's disease (tdPD). METHODS: 25 patients with tdPD underwent neuropsychological evaluation including standardized questionnaires of disability, quality of life (QoL), mood, anxiety, apathy, sleep disturbances, and cognition at baseline, 6 and 12 months after MRgFUS...
May 31, 2024: Journal of Neurology
https://read.qxmd.com/read/38816482/electroacupuncture-and-carbamazepine-for-patients-with-trigeminal-neuralgia-a-randomized-controlled-2%C3%A2-%C3%A3-%C3%A2-2-factorial-trial
#33
JOURNAL ARTICLE
Rongrong Li, Jing Sun, Kaitao Luo, Ning Luo, Ruohan Sun, Feng Gao, Yiyi Wang, Yunfan Xia, Xiaoyu Li, Lifang Chen, Ruijie Ma, Xiaomei Shao, Yi Liang, Jianqiao Fang
BACKGROUND: Trigeminal neuralgia (TN) is difficult to treat due to its severe pain intensity and recurring episodes, which significantly impact quality of life. OBJECTIVES: We aimed to assess the effectiveness of electroacupuncture (EA) in alleviating the pain intensity in TN, and to determine whether EA combined with low-dosage carbamazepine (CBZ) has a synergistic effect. METHODS: A multi-centre, randomized, 2 × 2 factorial trial was conducted...
May 31, 2024: Journal of Neurology
https://read.qxmd.com/read/38816481/predictors-of-seizure-detection-and-eeg-clinical-impact-in-an-italian-tertiary-emergency-department
#34
JOURNAL ARTICLE
Anna Bellini, Davide Gusmeo Curti, Marco Cursi, Giordano Cecchetti, Federica Agosta, Giovanna F Fanelli, Massimo Filippi
BACKGROUND AND OBJECTIVES: Epileptic seizures pose challenges in emergency departments (ED), affecting up to 10% of admitted patients. This study aimed to assess emergency electroencephalogram (EmEEG) utilization, identifying factors predicting seizure detection and its influence on clinical decisions. METHODS: A retrospective review of 1135 EmEEGs on 1017 patients at a tertiary teaching hospital between June 2022 and June 2023 was conducted. Data included demographics, medical history, EmEEG indications, neuroimaging findings, and clinical outcomes...
May 31, 2024: Journal of Neurology
https://read.qxmd.com/read/38816480/intelligent-devices-for-assessing-essential-tremor-a-comprehensive-review
#35
REVIEW
Yumeng Peng, Chenbin Ma, Mengwei Li, Yunmo Liu, Jinze Yu, Longsheng Pan, Zhengbo Zhang
Essential tremor (ET) stands as the most prevalent movement disorder, characterized by rhythmic and involuntary shaking of body parts. Achieving an accurate and comprehensive assessment of tremor severity is crucial for effectively diagnosing and managing ET. Traditional methods rely on clinical observation and rating scales, which may introduce subjective biases and hinder continuous evaluation of disease progression. Recent research has explored new approaches to quantifying ET. A promising method involves the use of intelligent devices to facilitate objective and quantitative measurements...
May 31, 2024: Journal of Neurology
https://read.qxmd.com/read/38816479/the-various-forms-of-hereditary-motor-neuron-disorders-and-their-historical-descriptions
#36
REVIEW
Stéphane Mathis, Diane Beauvais, Fanny Duval, Guilhem Solé, Gwendal Le Masson
Motor neuron disorders comprise a clinically and pathologically heterogeneous group of neurologic diseases characterized by progressive degeneration of motor neurons (including both sporadic and hereditary diseases), affecting the upper motor neurons, lower motor neurons, or both. Hereditary motor neuron disorders themselves represent a vast and heterogeneous group, with numerous clinical and genetic overlaps that can be a source of error. This narrative review aims at providing an overview of the main types of inherited motor neuron disorders by recounting the stages in their historical descriptions...
May 30, 2024: Journal of Neurology
https://read.qxmd.com/read/38811396/the-multiple-roles-of-nerve-biopsy-in-the-diagnosis-and-prognosis-of-suspected-immune-neuropathies
#37
JOURNAL ARTICLE
Rafael Klimas, Anna Kordes, Sophie Huckemann, Zornitsa Gasz, Jörg Philipps, Melissa Sgodzai, Thomas Grüter, Melis Sevindik, Christiane Schneider-Gold, Ralf Gold, Kathy Keyvani, Min-Suk Yoon, Anna Lena Fisse, Kalliopi Pitarokoili, Jeremias Motte
INTRODUCTION: The value of a sural nerve biopsy for the diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is controversial. Evidence-based recommendations for its implementation are lacking. We investigated factors leading to biopsy and analyzed biopsy outcomes and consequences, assessed the predictability of biopsy outcomes through clinical parameters to avoid unnecessary biopsies, and compared results with electrophysiological and clinical severity to determine their prognostic value...
May 29, 2024: Journal of Neurology
https://read.qxmd.com/read/38809271/short-term-cardiovascular-symptoms-improvement-after-deep-brain-stimulation-in-patients-with-parkinson-s-disease-a-systematic-review
#38
REVIEW
Francescopaolo Cucinotta, Bart Swinnen, Elena Makovac, Stephanie Hirschbichler, Erlick Pereira, Simon Little, Francesca Morgante, Lucia Ricciardi
BACKGROUND: Autonomic dysfunction is common and disabling in Parkinson's disease (PD). The effects of deep brain stimulation (DBS) on the cardiovascular system in PD remain poorly understood. We aimed to assess the effect of DBS on cardiovascular symptoms and objective measures in PD patients. METHODS: We conducted a systematic literature search in PubMed/MEDLINE. RESULTS: 36 out of 472 studies were included, mostly involving DBS of the subthalamic nucleus, and to a lesser extent the globus pallidus pars interna and pedunculopontine nucleus...
May 29, 2024: Journal of Neurology
https://read.qxmd.com/read/38809270/assessing-the-applicability-of-the-2023-international-mogad-panel-criteria-in-real-world-clinical-settings
#39
JOURNAL ARTICLE
Ariel Rechtman, Tal Freidman-Korn, Omri Zveik, Lyne Shweiki, Garrick Hoichman, Adi Vaknin-Dembinsky
INTRODUCTION: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently identified demyelinating disorder with a diverse clinical spectrum. Diagnosing MOGAD traditionally relies on clinical judgment, highlighting the necessity for precise diagnostic criteria. Banwell et al. proposed criteria, aiming to refine the diagnostic spectrum. This study evaluates these criteria in a real-life cohort, comparing their performance with clinical judgment and describe the cohort of MOGAD patients...
May 29, 2024: Journal of Neurology
https://read.qxmd.com/read/38806701/parkinson-s-disease-with-hyposmia-and-dysautonomia-does-it-represent-a-distinct-subtype
#40
JOURNAL ARTICLE
So Hoon Yoon, Dae Hyuk You, Han Kyu Na, Sungwoo Kang, Kyoungwon Baik, Mincheol Park, Chul Hyoung Lyoo, Young H Sohn, Phil Hyu Lee
BACKGROUND AND PURPOSE: Olfactory dysfunction or dysautonomia is one of the earliest prodromal nonmotor symptoms of Parkinson's disease (PD). We aimed to investigate whether PD patients with dysautonomia and hyposmia at the de novo stage present different prognoses regarding PD dementia (PDD) conversion, motor complication development, and change in levodopa-equivalent doses (LED). METHODS: In this retrograde cohort study, we included 105 patients with newly diagnosed PD patients who underwent cross-cultural smell identification test (CC-SIT), autonomic function tests (AFT), and dopamine transporter (DAT) scan at the de novo stage...
May 28, 2024: Journal of Neurology
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