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Journal of Neurology

Carl Moritz Zipser, Jeremy Deuel, Jutta Ernst, Maria Schubert, Michael Weller, Roland von Känel, Soenke Boettger
INTRODUCTION: Predisposing and precipitating factors for delirium are well known; however, their interaction and impact on delirium in neurological patients remains largely unknown. Therefore, those factors were evaluated in hospitalized patients with neurological disorders. METHODS: In this prospective cohort study, 1487 neurological patients were included, 356 patients with delirium and 1131 without delirium. Relevant neurological- and medical-related clusters were assessed with multiple regression analyses, prediction models, and cluster analysis evaluating their association with delirium...
September 13, 2019: Journal of Neurology
C Vollmuth, S Stoesser, H Neugebauer, A Hansel, J Dreyhaupt, A C Ludolph, J Kassubek, K Althaus
BACKGROUND: To date, insertable cardiac monitors (ICMs) are the most effective method for the detection of occult atrial fibrillation (AF) in cryptogenic stroke. The overall detection rate after 12 months, however, is low and ranges between 12.4 and 33.3%, even if clinical predictors are considered. Ischemic stroke patients due to cardiogenic embolism present with particular lesion patterns. In patients with cryptogenic stroke, MR-imaging pattern may be a valuable predictor for AF. METHODS: This is an MRI-based, retrospective, observational, comparative, single-center study of 104 patients who underwent ICM implantation after cryptogenic stroke...
September 11, 2019: Journal of Neurology
Ignacy Gonkowski, Liliana Rytel, Joanna Wojtkiewicz
No abstract text is available yet for this article.
September 10, 2019: Journal of Neurology
Philipp Eisele, Stefan Baumann, Laila Noor, Ibrahim El-Battrawy, Anne Ebert, Achim Gass, Ibrahim Akin, Maximilian Kittel, Michael Platten, Kristina Szabo
BACKGROUND: To analyse whether patients with transient global amnesia (TGA) have concomitant cardiac injury by assessing clinical symptoms, as well as blood and cardiologic test results. METHODS: In this retrospective observational study, we analysed 202 consecutive patients presenting with isolated TGA and treated at our institution between March 2010 and December 2018. We examined the incidence of high-sensitivity cardiac troponin I (hs-cTNI) level elevation, electrocardiogram (ECG) findings, and data on clinical management...
September 10, 2019: Journal of Neurology
Carlo Colosimo, David Charles, Vijay P Misra, Pascal Maisonobe, Savary Om
BACKGROUND: Patients with cervical dystonia (CD) typically require regular injections of botulinum toxin to maintain symptomatic control. We aimed to document long-term patient satisfaction with CD symptom control in a large cohort of patients treated in routine practice. METHODS: This was a prospective, international, observational study (NCT01753349) following the course of adult CD treated with botulinum neurotoxin type A (BoNT-A) over 3 years. A comprehensive clinical assessment status was performed at each injection visit and subjects reported satisfaction in two ways: satisfaction with symptom control at peak effect and at the end of treatment cycle...
September 9, 2019: Journal of Neurology
Franco Granella, Elena Tsantes, Stefania Graziuso, Veronica Bazzurri, Girolamo Crisi, Erica Curti
BACKGROUND: Spinal cord (SC) involvement correlates with poor prognosis in patients with multiple sclerosis (MS). Nevertheless, there is no consensus on the use of SC-MRI at follow-up, mainly because of the belief that SC lesions are nearly always symptomatic. OBJECTIVES: The aim of the present study was to investigate the frequency of asymptomatic SC combined unique activity (CUA, new/enlarging T2 or gadolinium-positive [Gd+] lesions) on MRI in a cohort of patients diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS)...
September 7, 2019: Journal of Neurology
S Shema-Shiratzky, E Gazit, R Sun, K Regev, A Karni, J J Sosnoff, T Herman, A Mirelman, Jeffrey M Hausdorff
Prolonged walking is typically impaired among people with multiple sclerosis (pwMS), however, it is unclear what the contributing factors are or how to evaluate this deterioration. We aimed to determine which gait features become worse during sustained walking and to examine the clinical correlates of gait fatigability in pwMS. Fifty-eight pwMS performed the 6-min walk test while wearing body-fixed sensors. Multiple gait domains (e.g., pace, rhythm, variability, asymmetry and complexity) were compared across each minute of the test and between mild- and moderate-disability patient groups...
September 6, 2019: Journal of Neurology
Lan Wen, Maolin Li, Tao Xu, Xinyuan Yu, Lijun Wang, Kunyi Li
BACKGROUND: Tuberculous meningitis (TBM) is one of the most life-threatening infectious diseases. We performed a systematic review and meta-analysis of the clinical features, outcomes, and prognostic factors for TBM in adults. METHODS: PubMed, EMBASE, Cochrane CENTRAL, and Web of Science were searched for studies that reported the clinical outcomes and/or risk factors for death in adults with TBM between January 1990 and July 2018. A random-effects meta-analysis model was used to pool data on clinical features, outcomes, and risk factors for death...
September 4, 2019: Journal of Neurology
Tho T H Dang, David Rowell, Jacki Liddle, Terry Coyne, Peter Silburn, Luke B Connelly
BACKGROUND: Deep-brain stimulation (DBS) can be effective in controlling medically intractable symptoms of Tourette's syndrome (TS). There is no evidence to date, though, of the potential cost-effectiveness of DBS for this indication. OBJECTIVE: To provide the first estimates of the likely cost-effectiveness of DBS in the treatment of severe TS. METHODS: We conducted a cost-utility analysis using clinical data from 17 Australian patients receiving DBS...
September 4, 2019: Journal of Neurology
Jayne L Chamberlain, Saif Huda, Daniel H Whittam, Marcelo Matiello, B Paul Morgan, Anu Jacob
The complement system is a powerful member of the innate immune system. It is highly adept at protecting against pathogens, but exists in a delicate balance between its protective functions and overactivity, which can result in autoimmune disease. A cascade of complement proteins that requires sequential activation, and numerous complement regulators, exists to regulate a proportionate response to pathogens. In spite of these mechanisms there is significant evidence for involvement of the complement system in driving the pathogenesis of variety of diseases including neuromyelitis optica spectrum disorders (NMOSD) and myasthenia gravis (MG)...
September 3, 2019: Journal of Neurology
N C Voermans, R C van der Bilt, J IJspeert, J Y Hogrel, M Jeanpierre, A Behin, P Laforet, T Stojkovic, B G van Engelen, G W Padberg, S Sacconi, R J L F Lemmers, S M van der Maarel, B Eymard, G Bassez
OBJECTIVE: To study scapular winging or other forms of scapular dyskinesis (condition of alteration of the normal position and motion of the scapula) in myotonic dystrophy type 1 (DM1), which is generally considered to be a distal myopathy, we performed an observational cohort study. METHODS: We performed a prospective cohort study on the clinical features and progression over time of 33 patients with DM1 and pronounced, mostly asymmetric scapular winging or other forms of scapular dyskinesis...
August 31, 2019: Journal of Neurology
Yao Zhou, Yanchun Yuan, Zhen Liu, Sheng Zeng, Zhao Chen, Lu Shen, Hong Jiang, Kun Xia, Beisha Tang, Junling Wang
BACKGROUND: Spinocerebellar ataxia type 8 (SCA8) is a rare autosomal dominant neurodegenerative disease caused by CTA/CTG repeat expansion in the ATXN8/ATXN8OS gene. METHODS: To analyze the frequency and clinical characteristics of SCA8 patients in mainland China, we combined polymerase chain reaction (PCR) and triplet repeat-primed PCR (TRP-PCR) to detect the CTA/CTG expansion. We studied a cohort of 362 ataxia patients in which the other known causative genes had been previously excluded, from among 1294 index patients...
August 30, 2019: Journal of Neurology
Shuju Dong, Jian Guo, Jinghuan Fang, Ye Hong, Shuhui Cui, Li He
OBJECTIVES: Pre-stroke statin use reduces stroke severity and improves functional outcomes; however, whether low-dose statins as a primary preventive measure have similar effects on the Chinese population remains unclear. METHODS: Consecutive cases of ischaemic stroke between May 2011 and January 2017 were retrospectively analysed. The primary endpoints were stroke severity on admission and functional outcomes at 90 days. The secondary endpoints were factors related to lower stroke severity on admission...
August 29, 2019: Journal of Neurology
Marina Svetel, Aleksandra Tomić, Nataša Dragašević, Igor Petrović, Nikola Kresojević, Robert Jech, Dušan Urgošik, Isidora Banjac, Jelena Vitković, Ivana Novaković, Vladimir S Kostić
INTRODUCTION: Pantothenate kinase-associated neurodegeneration (PKAN) is a rare autosomal recessive disorder with a progressive clinical course. In addition to symptomatic therapy, DBS has been increasingly recognized as a potential therapeutic strategy, especially in severe cases. Therefore, we wanted to report our experience regarding benefits of DBS in five PKAN cases in 3-year follow-up study. METHODS: Five genetically confirmed PKAN patients from Serbia underwent GPi-DBS...
August 29, 2019: Journal of Neurology
Andreas Zwergal, Eva Grill, Christophe Lopez, Marianne Dieterich
No abstract text is available yet for this article.
August 28, 2019: Journal of Neurology
Daisuke Ito, Atsushi Hashizume, Yasuhiro Hijikata, Shinichiro Yamada, Yohei Iguchi, Madoka Iida, Yoshiyuki Kishimoto, Hideyuki Moriyoshi, Akihiro Hirakawa, Masahisa Katsuno
OBJECTIVE: To assess the changes of muscle-related biomarkers at the early stage of amyotrophic lateral sclerosis, and to confirm these findings in an experimental animal model. METHODS: Thirty-nine subjects with sporadic amyotrophic lateral sclerosis and 20 healthy controls were enrolled and longitudinally evaluated. We evaluated serum creatine kinase and creatinine levels and appendicular lean soft-tissue mass using dual X-ray absorptiometry. The levels of biomarkers at early ALS stages were estimated using linear mixed models with unstructured correlation and random intercepts...
August 27, 2019: Journal of Neurology
Urvish K Patel, Arsalan Anwar, Sidra Saleem, Preeti Malik, Bakhtiar Rasul, Karan Patel, Robert Yao, Ashok Seshadri, Mohammed Yousufuddin, Kogulavadanan Arumaithurai
BACKGROUND: Artificial intelligence (AI) has influenced all aspects of human life and neurology is no exception to this growing trend. The aim of this paper is to guide medical practitioners on the relevant aspects of artificial intelligence, i.e., machine learning, and deep learning, to review the development of technological advancement equipped with AI, and to elucidate how machine learning can revolutionize the management of neurological diseases. This review focuses on unsupervised aspects of machine learning, and how these aspects could be applied to precision neurology to improve patient outcomes...
August 26, 2019: Journal of Neurology
Cécilia Tremblay, Rosa Emrich, Annachiara Cavazzana, Lisa Klingelhoefer, Moritz D Brandt, Thomas Hummel, Antje Haehner, Johannes Frasnelli
Olfactory dysfunction is a frequent early non-motor symptom of Parkinson's disease (PD). There is evidence that with regard to trigeminal perception, PD-related olfactory dysfunction is different from other olfactory disorders. More specifically, trigeminal sensitivity, when measured behaviorally, was unimpaired in PD patients as opposed to patients with non-Parkinsonian olfactory dysfunction (NPOD). We sought to investigate the trigeminal pathway by measuring electrophysiological recordings from the nasal epithelium and EEG-derived event-related potentials in response to a specific trigeminal stimulus in 21 PD patients and compare them to 23 patients with NPOD and 25 controls (C)...
August 26, 2019: Journal of Neurology
Lucia Gerstl, Raphael Weinberger, Florian Heinen, Michaela V Bonfert, Ingo Borggraefe, A Sebastian Schroeder, Moritz Tacke, Mirjam N Landgraf, Katharina Vill, Karin Kurnik, Anna-Lisa Sorg, Martin Olivieri
OBJECTIVE: Childhood arterial ischaemic stroke (AIS) is rare, but causes significant morbidity and mortality. We aimed to investigate incidence, age-dependent clinical presentation, and risk factors and to discuss the medical care situation in Germany. METHODS: This prospective epidemiological study was conducted via ESPED (Erhebungseinheit für Seltene Pädiatrische Erkrankungen in Deutschland), a hospital-based German nation-wide surveillance unit for rare pediatric diseases...
August 23, 2019: Journal of Neurology
Stefano Gelibter, Mario Orrico, Tommaso Croese, Luca Bosco, Vittorio Martinelli, Francesca Sangalli, Massimo Filippi
No abstract text is available yet for this article.
August 21, 2019: Journal of Neurology
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