journal
https://read.qxmd.com/read/36436069/structural-and-functional-magnetic-resonance-imaging-correlates-of-fatigue-and-dual-task-performance-in-progressive-multiple-sclerosis
#1
JOURNAL ARTICLE
Paolo Preziosa, Maria A Rocca, Elisabetta Pagani, Paola Valsasina, Maria Pia Amato, Giampaolo Brichetto, Nicolò Bruschi, Jeremy Chataway, Nancy D Chiaravalloti, Gary Cutter, Ulrik Dalgas, John DeLuca, Rachel Farrell, Peter Feys, Jennifer Freeman, Matilde Inglese, Alessandro Meani, Cecilia Meza, Robert W Motl, Amber Salter, Brian M Sandroff, Anthony Feinstein, Massimo Filippi
BACKGROUND: Frontal cortico-subcortical dysfunction may contribute to fatigue and dual-task impairment of walking and cognition in progressive multiple sclerosis (PMS). PURPOSE: To explore the associations among fatigue, dual-task performance and structural and functional abnormalities of frontal cortico-subcortical network in PMS. METHODS: Brain 3 T structural and functional MRI sequences, Modified Fatigue Impact Scale (MFIS), dual-task motor and cognitive performances were obtained from 57 PMS patients and 10 healthy controls (HC)...
November 27, 2022: Journal of Neurology
https://read.qxmd.com/read/36436068/onset-and-mortality-of-parkinson-s-disease-in-relation-to-type-ii-diabetes
#2
JOURNAL ARTICLE
Gianni Pezzoli, Emanuele Cereda, Paolo Amami, Santo Colosimo, Michela Barichella, Giorgio Sacilotto, Anna Zecchinelli, Michela Zini, Valentina Ferri, Carlotta Bolliri, Daniela Calandrella, Maria Grazia Bonelli, Viviana Cereda, Elisa Reali, Serena Caronni, Erica Cassani, Margherita Canesi, Francesca Del Sorbo, Paola Soliveri, Luigi Zecca, Catherine Klersy, Roberto Cilia, Ioannis U Isaias
OBJECTIVES: There is growing evidence that Parkinson's disease and diabetes are partially related diseases; however, the association between the two, and the impact of specific treatments, are still unclear. We evaluated the effect of T2D and antidiabetic treatment on age at PD onset and on all-cause mortality. RESEARCH DESIGN AND METHODS: The standardized rate of T2D was calculated for PD patients using the direct method and compared with subjects with essential tremor (ET) and the general Italian population...
November 27, 2022: Journal of Neurology
https://read.qxmd.com/read/36434128/mri-spot-sign-in-acute-intracerebral-hemorrhage-an-independent-biomarker-of-hematoma-expansion-and-poor-functional-outcome
#3
JOURNAL ARTICLE
Nefeli Valyraki, Adrien Goujon, Marjorie Mateos, Adrien Lecoeuvre, Augustin Lecler, Igor Raynouard, Candice Sabben, Michael Obadia, Julien Savatovsky, Pierre Seners
BACKGROUND: In acute intracerebral hemorrhage (ICH), the prognostic value of the MRI spot sign on hematoma expansion (HE) and poor functional outcome is poorly known. METHODS: We retrospectively included patients admitted over a 4-year period for an acute ICH in a single institution using MRI as the first-line imaging tool. The presence and number of MRI spot signs on contrast-enhanced T1-weighted imaging was evaluated by one neuroradiologist, blinded from outcomes...
November 25, 2022: Journal of Neurology
https://read.qxmd.com/read/36434127/botulinum-toxin-antibody-titres-measurement-interpretation-and-practical-recommendations
#4
JOURNAL ARTICLE
Dirk Dressler, John C Rothwell, Kailash Bhatia, Bruno Kopp, Hans Bigalke, Fereshte Adib Saberi
Botulinum toxin (BT) therapy may be blocked by antibodies (BT-AB) resulting in BT-AB induced therapy failure (ABF). BT-AB may be detected by the mouse lethality assay (MLA), the mouse diaphragm assay (MDA) and the sternocleidomastoid test (SCMT). For the first time, we wanted to compare all three BT-AB tests and correlate them to subjective complaint of complete or partial secondary therapy failure in 37 patients with cervical dystonia (25 females, 12 males, age 51.2 ± 11.4 years, disease duration 12...
November 24, 2022: Journal of Neurology
https://read.qxmd.com/read/36427168/present-and-future-of-the-diagnostic-work-up-of-multiple-sclerosis-the-imaging-perspective
#5
REVIEW
Massimo Filippi, Paolo Preziosa, Douglas L Arnold, Frederik Barkhof, Daniel M Harrison, Pietro Maggi, Caterina Mainero, Xavier Montalban, Elia Sechi, Brian G Weinshenker, Maria A Rocca
In recent years, the use of magnetic resonance imaging (MRI) for the diagnostic work-up of multiple sclerosis (MS) has evolved considerably. The 2017 McDonald criteria show high sensitivity and accuracy in predicting a second clinical attack in patients with a typical clinically isolated syndrome and allow an earlier diagnosis of MS. They have been validated, are evidence-based, simplify the clinical use of MRI criteria and improve MS patients' management. However, to limit the risk of misdiagnosis, they should be applied by expert clinicians only after the careful exclusion of alternative diagnoses...
November 24, 2022: Journal of Neurology
https://read.qxmd.com/read/36422669/multidomain-cognitive-impairment-in-non-hospitalized-patients-with-the-post-covid-19-syndrome-results-from-a-prospective-monocentric-cohort
#6
JOURNAL ARTICLE
Ann-Katrin Schild, Yasemin Goereci, Daniel Scharfenberg, Kim Klein, Joachim Lülling, Dix Meiberth, Finja Schweitzer, Sophie Stürmer, Philip Zeyen, Derya Sahin, Gereon R Fink, Frank Jessen, Christiana Franke, Oezguer A Onur, Josef Kessler, Clemens Warnke, Franziska Maier
BACKGROUND: A fraction of patients with asymptomatic to mild/moderate acute COVID-19 disease report cognitive deficits as part of the post-COVID-19 syndrome. This study aimed to assess the neuropsychological profile of these patients. METHODS: Assessment at baseline (three months or more following acute COVID-19) of a monocentric prospective cohort of patients with post-COVID-19 syndrome. Multidomain neuropsychological tests were performed, and questionnaires on depression, anxiety, fatigue, sleep, and general health status were administered...
November 23, 2022: Journal of Neurology
https://read.qxmd.com/read/36422668/smartphone-video-nystagmography-using-convolutional-neural-networks-convng
#7
JOURNAL ARTICLE
Maximilian U Friedrich, Erich Schneider, Miriam Buerklein, Johannes Taeger, Johannes Hartig, Jens Volkmann, Robert Peach, Daniel Zeller
BACKGROUND: Eye movement abnormalities are commonplace in neurological disorders. However, unaided eye movement assessments lack granularity. Although videooculography (VOG) improves diagnostic accuracy, resource intensiveness precludes its broad use. To bridge this care gap, we here validate a framework for smartphone video-based nystagmography capitalizing on recent computer vision advances. METHODS: A convolutional neural network was fine-tuned for pupil tracking using > 550 annotated frames: ConVNG...
November 23, 2022: Journal of Neurology
https://read.qxmd.com/read/36414751/use-of-remote-monitoring-and-integrated-platform-for-the-evaluation-of-sleep-quality-in-adult-onset-idiopathic-cervical-dystonia
#8
JOURNAL ARTICLE
Grace A Bailey, Clare Matthews, Konrad Szewczyk-Krolikowski, Peter Moore, Sandra Komarzynski, Elin Haf Davies, Kathryn J Peall
BACKGROUND: Up to 70% of individuals diagnosed with adult-onset idiopathic focal cervical dystonia (AOIFCD) report difficulties with sleep. Larger cohort studies using wrist-worn accelerometer devices have emerged as an alternative to smaller polysomnography studies, in order to evaluate sleep architecture. METHODS: To measure activity during the sleep/wake cycle, individuals wore a consumer-grade wrist device (Garmin vivosmart 4) continuously over 7 days on their non-dominant wrist, while completing a daily sleep diary and standardised sleep and non-motor questionnaires via a dedicated app...
November 21, 2022: Journal of Neurology
https://read.qxmd.com/read/36411388/exome-based-gene-panel-analysis-in-a-cohort-of-acute-juvenile-ischemic-stroke-patients-relevance-of-notch3-and-gla-variants
#9
JOURNAL ARTICLE
Johanna Härtl, Julia Hartberger, Silke Wunderlich, Isabell Cordts, Cemsel Bafligil, Marc Sturm, Dominik Westphal, Tobias Haack, Bernhard Hemmer, Benno David Ikenberg, Marcus Deschauer
BACKGROUND: Genetic variants are considered to have a crucial impact on the occurrence of ischemic stroke. In clinical routine, the diagnostic value of next-generation sequencing (NGS) in the medical clarification of acute juvenile stroke has not been investigated so far. MATERIAL AND METHODS: We analyzed an exome-based gene panel of 349 genes in 172 clinically well-characterized patients with magnetic resonance imaging (MRI)-proven, juvenile (age ≤ 55 years), ischemic stroke admitted to a single comprehensive stroke center...
November 21, 2022: Journal of Neurology
https://read.qxmd.com/read/36411387/heterogeneity-of-persisting-symptoms-after-sport-related-concussion-src-exploring-symptom-subtypes-and-patient-subgroups
#10
JOURNAL ARTICLE
S Langdon, E Goedhart, M Inklaar, J Oosterlaan, M Königs
This study aimed to explore the heterogeneity of persisting symptoms after sport-related concussion (SRC). We examined the structure of symptom subtypes within 163 patients with SRC (M = 16.7 weeks post-injury). Subsequently, we investigated the existence of subgroups of patients based on comparable configuration of co-occurring symptom subtypes. To explore factors that may contribute to the emergence of SRC patient subgroups, subgroups were compared on pre-injury (i.e., demographics and medical history), personality (Severity Indices of Personality Problems Short Form) and SRC characteristics (i...
November 21, 2022: Journal of Neurology
https://read.qxmd.com/read/36399165/inclusion-body-myositis-from-genetics-to-clinical-trials
#11
JOURNAL ARTICLE
Sara Nagy, Alaa Khan, Pedro M Machado, Henry Houlden
Inclusion body myositis (IBM) belongs to the group of idiopathic inflammatory myopathies and is characterized by a slowly progressive disease course with asymmetric muscle weakness of predominantly the finger flexors and knee extensors. The disease leads to severe disability and most patients lose ambulation due to lack of curative or disease-modifying treatment options. Despite some genes reported to be associated with hereditary IBM (a distinct group of conditions), data on the genetic susceptibility of sporadic IBM are very limited...
November 18, 2022: Journal of Neurology
https://read.qxmd.com/read/36396814/identification-of-hub-proteins-in-cerebrospinal-fluid-as-potential-biomarkers-of-alzheimer-s-disease-by-integrated-bioinformatics
#12
JOURNAL ARTICLE
Yang Li, Zuolong Chen, Qiong Wang, Xinyi Lv, Zhaozhao Cheng, Yan Wu, Fang Tang, Yong Shen, Feng Gao
BACKGROUND: Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease with complex pathophysiology. Therefore, the identification of novel effective fluid biomarkers is essential for Alzheimer's disease diagnosis and drug development. This study aimed to identify potential candidate hub proteins in cerebrospinal fluid for precise Alzheimer's disease diagnosis using bioinformatics methods. METHODS: A total of 29 co-significant differentially expressed proteins were identified by differential protein expression analysis in four different cohorts...
November 18, 2022: Journal of Neurology
https://read.qxmd.com/read/36396813/persistent-hiccups-as-main-covid-19-manifestation-with-transient-cytotoxic-lesion-of-the-corpus-callosum-splenium-during-the-omicron-wave-in-the-post-vaccination-era
#13
LETTER
Celeste Sassi, Emel Mehmed, Amir Alkhatib, Mario Alberto Forero-Padilla, Dragan S Goranov, Sylvia Habermann, Sven Rekow, Albert Grüger, Hans-Michael Schmitt
No abstract text is available yet for this article.
November 18, 2022: Journal of Neurology
https://read.qxmd.com/read/36396812/optical-coherence-tomography-oct-measurements-and-cognitive-performance-in-multiple-sclerosis-a-systematic-review-and-meta-analysis
#14
REVIEW
Omid Mirmosayyeb, Robert Zivadinov, Bianca Weinstock-Guttman, Ralph H B Benedict, Dejan Jakimovski
BACKGROUND: Several studies report mixed associations between the retinal nerve fiber layer (RNFL) thickness with cognitive and physical disability in persons with multiple sclerosis (PwMS). Systematic synthesis of these findings is crucial in deriving credible conclusions. METHODS: Five databases were searched from their inception to March 2022. The inclusion criteria for studies were MS-specific and required RNFL and cognitive performance data in order to be analyzed...
November 17, 2022: Journal of Neurology
https://read.qxmd.com/read/36396811/clinical-pitfalls-and-serological-diagnostics-of-musk-myasthenia-gravis
#15
JOURNAL ARTICLE
Young Nam Kwon, Mark Woodhall, Jung-Joon Sung, Kwang-Kuk Kim, Young-Min Lim, Hyunjin Kim, Jee-Eun Kim, Seol-Hee Baek, Byung-Jo Kim, Jin-Sung Park, Hung Youl Seok, Dae-Seong Kim, Ohyun Kwon, Kee Hong Park, Eunhee Sohn, Jong Seok Bae, Byung-Nam Yoon, Nam-Hee Kim, Suk-Won Ahn, Kyomin Choi, Jeeyoung Oh, Hyung Jun Park, Kyong Jin Shin, Sanggon Lee, Jinseok Park, Seung Hyun Kim, Jung Im Seok, Dae Woong Bae, Jae Young An, In Soo Joo, Seok-Jin Choi, Tai-Seung Nam, Sunyoung Kim, Ki-Jong Park, Ki-Han Kwon, Patrick Waters, Yoon-Ho Hong
BACKGROUND: We aimed to evaluate the diagnostic accuracy of enzyme-linked immunosorbent assay (ELISA) for anti-muscle specific tyrosine kinase (MuSK) antibody (Ab) in a large cohort of anti-acetylcholine receptor (AChR) Ab-negative generalized myasthenia gravis (MG), and also to investigate clinical contexts for the diagnosis of MuSK MG. METHODS: A retrospective study of 160 patients with a clinical suspicion of AChR Ab-negative generalized MG was performed. The serum samples were tested for anti-clustered AChR Ab by cell-based assay (CBA), anti-MuSK Ab by ELISA, CBA and/or radioimmunoprecipitation assay (RIPA)...
November 17, 2022: Journal of Neurology
https://read.qxmd.com/read/36385202/motor-symptoms-in-genetic-frontotemporal-dementia-developing-a-new-module-for-clinical-rating-scales
#16
JOURNAL ARTICLE
Kiran Samra, Amy M MacDougall, Georgia Peakman, Arabella Bouzigues, Martina Bocchetta, David M Cash, Caroline V Greaves, Rhian S Convery, John C van Swieten, Lize Jiskoot, Harro Seelaar, Fermin Moreno, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Mario Masellis, Carmela Tartaglia, James B Rowe, Barbara Borroni, Elizabeth Finger, Matthis Synofzik, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Chris R Butler, Alexander Gerhard, Simon Ducharme, Isabelle Le Ber, Pietro Tiraboschi, Isabel Santana, Florence Pasquier, Johannes Levin, Markus Otto, Sandro Sorbi, Jonathan D Rohrer, Lucy L Russell
OBJECTIVE: To investigate the optimal method of adding motor features to a clinical rating scale for frontotemporal dementia (FTD). METHODS: Eight hundred and thirty-two participants from the international multicentre Genetic FTD Initiative (GENFI) study were recruited: 522 mutation carriers (with C9orf72, GRN and MAPT mutations) and 310 mutation-negative controls. A standardised clinical questionnaire was used to assess eight motor symptoms (dysarthria, dysphagia, tremor, slowness, weakness, gait disorder, falls and functional difficulties using hands)...
November 17, 2022: Journal of Neurology
https://read.qxmd.com/read/36385201/longitudinal-study-of-multi-parameter-quantitative-magnetic-resonance-imaging-in-duchenne-muscular-dystrophy-hyperresponsiveness-of-gluteus-maximus-and-detection-of-subclinical-disease-progression-in-functionally-stable-patients
#17
JOURNAL ARTICLE
Fei Peng, Huayan Xu, Yu Song, Ke Xu, Shuhao Li, Xiaotang Cai, Yingkun Guo, Lianggeng Gong
OBJECTIVE: To describe the disease progression of Duchenne muscular dystrophy (DMD) in the pelvic and thigh muscles over 1-year using multiple-parameter quantitative magnetic resonance imaging (qMRI), and to determine the most responsive muscle and predict subclinical disease progression in functionally stable patients. METHODS: Fifty-four DMD patients (mean age 8.9 ± 2.5, range 5-15 years) completed baseline and 1-year follow-up qMRI examinations/biomarkers [3-point Dixon/fat fraction (FF); T1 mapping/T1; T2 mapping/T2]...
November 16, 2022: Journal of Neurology
https://read.qxmd.com/read/36383260/anti-titin-antibodies-are-associated-with-myocarditis-in-patients-with-myasthenia-gravis
#18
JOURNAL ARTICLE
Sohyeon Kim, Ki Hoon Kim, Hye Yoon Chung, Hyung Jun Park, Young-Chul Choi, Ha Young Shin, Seung Woo Kim
BACKGROUND: Myasthenia gravis (MG) can affect cardiac muscles with variable presentations. Myocarditis is a rare but potentially serious cardiac manifestation of MG. Although thymomas and anti-titin antibodies have been suggested as risk factors for myocarditis in patients with MG, their independent influence on myocarditis has rarely been assessed. METHODS: A retrospective chart review was conducted on 247 patients diagnosed with MG who were tested for anti-titin antibodies...
November 16, 2022: Journal of Neurology
https://read.qxmd.com/read/36383259/italian-version-of-the-rasch-built-overall-amyotrophic-lateral-sclerosis-disability-scale-roads-validation-and-longitudinal-performance
#19
JOURNAL ARTICLE
Andrea Fortuna, Daniele Sabbatini, Annachiara Frigo, Luca Bello, Francesca Calvi, Lorenzo Blasi, Giulia Gianferrari, Ilaria Martinelli, Giacomo Minicuci, Elena Pegoraro, Jessica Mandrioli, Gianni Sorarù
OBJECTIVE: To validate an Italian version of the Rasch-Built Overall ALS Disability Scale (ROADS) in a broad population of patients and assess its longitudinal performance over time. METHODS: 270 ALS patients referring to the Motor Neuron Disease Clinic of the University of Padova and Modena (Italy) accepted to compile the Italian version of the ROADS and results were correlated with the ALSFRSr and ALSAQ-40 scores, FVC values, and creatinine or albumin blood levels...
November 16, 2022: Journal of Neurology
https://read.qxmd.com/read/36380166/assessment-of-cognitive-function-structural-brain-changes-and-fatigue-6-months-after-treatment-of-neuroborreliosis
#20
JOURNAL ARTICLE
Silje Andreassen, Elisabeth Margrete Stokke Lindland, Mona Kristiansen Beyer, Anne Marit Solheim, Unn Ljøstad, Åse Mygland, Åslaug Rudjord Lorentzen, Harald Reiso, Knut Jørgen Bjuland, Are Hugo Pripp, Hanne Flinstad Harbo, Gro Christine Christensen Løhaugen, Randi Eikeland
BACKGROUND: Complete recovery after adequately treated neuroborreliosis is common, but studies report that some patients experience persistent symptoms like self-reported cognitive problems and fatigue. Persisting symptoms are often termed post-Lyme disease syndrome, of which etiology is not clearly understood. The aim of this study was to investigate cognitive function, possible structural changes in brain regions and level of fatigue. We have not found previous studies on neuroborreliosis that use standardized neuropsychological tests and MRI with advanced image processing to investigate if there are subtle regional changes in cortical thickness and brain volumes after treatment...
November 15, 2022: Journal of Neurology
journal
journal
20158
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.