journal
https://read.qxmd.com/read/36971841/the-evolution-of-diagnosis-from-symptom-onset-to-death-in-progressive-supranuclear-palsy-psp-and-corticobasal-degeneration-cbd-compared-to-parkinson-s-disease-pd
#1
JOURNAL ARTICLE
Diane M A Swallow, Carl E Counsell
BACKGROUND: Misdiagnosis and delayed diagnosis in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are common. Few studies have systematically evaluated the diagnostic process from symptom onset to death in representative cohorts. METHODS: All PSP/CBD cases (n = 28/2) and age-sex matched Parkinson's disease (PD) cases (n = 30) were identified from a UK prospective incident Parkinsonism cohort. Medical and research records were reviewed to compare median times from first index symptom to key diagnostic milestones and the nature/timing of secondary care referral and review...
March 27, 2023: Journal of Neurology
https://read.qxmd.com/read/36961527/cerebral-amyloid-angiopathy-an-update
#2
JOURNAL ARTICLE
B E Schroeder, N P Robertson, T A T Hughes
No abstract text is available yet for this article.
March 24, 2023: Journal of Neurology
https://read.qxmd.com/read/36952012/transcranial-direct-current-stimulation-enhances-motor-learning-in-parkinson-s-disease-a-randomized-controlled-trial
#3
JOURNAL ARTICLE
Sanne Broeder, Britt Vandendoorent, Pauline Hermans, Evelien Nackaerts, Geert Verheyden, Raf Meesen, Jean-Jacques Orban de Xivry, Alice Nieuwboer
Writing training has shown clinical benefits in Parkinson's disease (PD), albeit with limited retention and insufficient transfer effects. It is still unknown whether anodal transcranial direct current stimulation (atDCS) can boost consolidation in PD and how this interacts with medication. To investigate the effects of training + atDCS versus training + sham stimulation on consolidation of writing skills when ON and OFF medication. Second, to examine the intervention effects on cortical excitability...
March 23, 2023: Journal of Neurology
https://read.qxmd.com/read/36952011/the-behavioural-dysfunction-questionnaire-discriminates-behavioural-variant-frontotemporal-dementia-from-alzheimer-s-disease-dementia-and-major-depressive-disorder
#4
JOURNAL ARTICLE
Anna Semenkova, Olivier Piguet, Andreas Johnen, Matthias L Schroeter, Jannis Godulla, Christoph Linnemann, Markus Mühlhauser, Thomas Sauer, Markus Baumgartner, Sarah Anderl-Straub, Markus Otto, Ansgar Felbecker, Reto W Kressig, Manfred Berres, Marc Sollberger
BACKGROUND AND OBJECTIVES: Early-stage behavioural variant frontotemporal dementia (bvFTD) is often misdiagnosed, highlighting the need for new diagnostic instruments. Based on the revised diagnostic criteria for bvFTD, we developed the Behavioural Dysfunction Questionnaire (BDQ). In this explorative study, we aimed to determine the best scoring and analytical method for the BDQ to discriminate between bvFTD and non-bvFTD patients. MATERIALS AND METHODS: 34 patients with early-stage bvFTD, 56 with early-stage Alzheimer's disease dementia (ADD) and 41 with major depressive disorder (MDD) were recruited...
March 23, 2023: Journal of Neurology
https://read.qxmd.com/read/36952010/assessment-of-cognitive-performance-in-multiple-sclerosis-using-smartphone-based-training-games-a-feasibility-study
#5
JOURNAL ARTICLE
Silvan Pless, Tim Woelfle, Yvonne Naegelin, Johannes Lorscheider, Andrea Wiencierz, Óscar Reyes, Pasquale Calabrese, Ludwig Kappos
BACKGROUND: Cognitive impairment occurs in up to 70% of people with MS (pwMS) and has a large impact on quality of life and working capacity. As part of the development of a smartphone-app (dreaMS) for monitoring MS disease activity and progression, we assessed the feasibility and acceptance of using cognitive games as assessment tools for cognitive domains. METHODS: We integrated ten cognitive games in the dreaMS app. Participants were asked to play these games twice a week for 5 weeks...
March 23, 2023: Journal of Neurology
https://read.qxmd.com/read/36944760/good-vibrations-tactile-cueing-for-freezing-of-gait-in-parkinson-s-disease
#6
JOURNAL ARTICLE
E C Klaver, J P P van Vugt, B R Bloem, R J A van Wezel, J Nonnekes, M C Tjepkema-Cloostermans
BACKGROUND: Cueing strategies can alleviate freezing of gait (FOG) in people with Parkinson's disease (PD). We evaluated tactile cueing delivered via vibrating socks, which has the benefit of not being noticeable to bystanders. OBJECTIVE: To evaluate the effect of tactile cueing compared to auditory cueing on FOG. METHODS: Thirty-one persons with PD with FOG performed gait tasks during both ON and OFF state. The effect of open loop and closed loop tactile cueing, as delivered by vibrating socks, was compared to an active control group (auditory cueing) and to a baseline condition (uncued gait)...
March 21, 2023: Journal of Neurology
https://read.qxmd.com/read/36943516/covid19-associated-new-onset-movement-disorders-a-follow-up-study
#7
JOURNAL ARTICLE
Susanne A Schneider, Soaham Desai, Onanong Phokaewvarangkul, Elena Cecilia Rosca, Jirada Sringean, Pria Anand, Gary Álvarez Bravo, Francisco Cardoso, Anna M Cervantes-Arslanian, Harshad Chovatiya, David Crosiers, Femke Dijkstra, Conor Fearon, Francisco Grandas, Eric Guedj, Antonio Méndez-Guerrero, Muhammad Hassan, Joseph Jankovic, Anthony E Lang, Karim Makhoul, Lorenzo Muccioli, Sarah A O'Shea, Vahid Reza Ostovan, Javier Ricardo Perez-Sanchez, Ritesh Ramdhani, Victoria Ros-Castelló, Christina Schulte, Priyank Shah, Lars Wojtecki, Pramod Kumar Pal
BACKGROUND: Neurological symptoms are common manifestation in acute COVID-19. This includes hyper- and hypokinetic movement disorders. Data on their outcome, however, is limited. METHODS: Cases with new-onset COVID-19-associated movement disorders were identified by searching the literature. Authors were contacted for outcome data which were reviewed and analyzed. RESULTS: Movement disorders began 12.6 days on average after the initial onset of COVID-19...
March 21, 2023: Journal of Neurology
https://read.qxmd.com/read/36943515/letter-to-the-editors-comment-on-status-dystonicus-in-adult-patients-with-anti-n-methyl-d-asparate-acid-receptor-encephalitis
#8
LETTER
Daniel E Lumsden, Ming Lim, Sarosh Irani
No abstract text is available yet for this article.
March 21, 2023: Journal of Neurology
https://read.qxmd.com/read/36939934/additive-effect-of-dnajc30-and-ndufa9-mutations-causing-leigh-syndrome
#9
LETTER
Claudia Nesti, Chiara Ticci, Anna Rubegni, Stefano Doccini, Giusi Scaturro, Annalisa Vetro, Renzo Guerrini, Filippo M Santorelli, Elena Procopio
No abstract text is available yet for this article.
March 20, 2023: Journal of Neurology
https://read.qxmd.com/read/36939933/baseline-brain-imaging-signs-in-patients-with-ischaemic-stroke-by-the-presence-of-atrial-fibrillation-the-enchanted-trial
#10
JOURNAL ARTICLE
Xia Wang, Shoujiang You, Zien Zhou, Candice Delcourt, Joanna Wardlaw, Grant Mair, Thompson Robinson, Xiaoying Chen, Sohei Yoshimura, Takako Torii-Yoshimura, Cheryl Carcel, Alejandra Malavera, Craig Anderson, Richard I Lindley
BACKGROUND: We aimed to assess the association of atrial fibrillation (AF) on outcomes in a post hoc analysis of the ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study) and how this association is modified by baseline imaging features. METHODS: Inverse probability of treatment weight was used to remove baseline imbalances between those with and without AF. The primary outcome was the modified Rankin Scale (mRS) scores at 90 days. Secondary outcomes were symptomatic intracerebral haemorrhage (sICH), early neurological deterioration or death within 24 h, and death at 90 days...
March 20, 2023: Journal of Neurology
https://read.qxmd.com/read/36939932/covid-19-severity-is-related-to-poor-executive-function-in-people-with-post-covid-conditions
#11
JOURNAL ARTICLE
Mar Ariza, Neus Cano, Bàrbara Segura, Ana Adan, Núria Bargalló, Xavier Caldú, Anna Campabadal, Maria Angeles Jurado, Maria Mataró, Roser Pueyo, Roser Sala-Llonch, Cristian Barrué, Javier Bejar, Claudio Ulises Cortés, Maite Garolera, Carme Junqué
Patients with post-coronavirus disease 2019 (COVID-19) conditions typically experience cognitive problems. Some studies have linked COVID-19 severity with long-term cognitive damage, while others did not observe such associations. This discrepancy can be attributed to methodological and sample variations. We aimed to clarify the relationship between COVID-19 severity and long-term cognitive outcomes and determine whether the initial symptomatology can predict long-term cognitive problems. Cognitive evaluations were performed on 109 healthy controls and 319 post-COVID individuals categorized into three groups according to the WHO clinical progression scale: severe-critical (n = 77), moderate-hospitalized (n = 73), and outpatients (n = 169)...
March 20, 2023: Journal of Neurology
https://read.qxmd.com/read/36939931/dysautonomia-associated-with-immune-checkpoint-inhibitors
#12
JOURNAL ARTICLE
Toshiki Tezuka, Shinichi Okuzumi, Chiho Nakashima, Toshihiro Ide, Shungo Imai, Satoru Mitsuboshi, Yuki Kuwahara, Tsubasa Takizawa, Morinobu Seki, Naoto Minematsu, Naoko Aragane, Jin Nakahara, Satoko Hori, Shunya Nakane, Shigeaki Suzuki
OBJECTIVE: The purpose of this study is to report the clinical characteristics of dysautonomia associated with immune checkpoint inhibitors (ICIs). METHODS: We reported two patients with autoimmune autonomic ganglionopathy (AAG) occurring as immune-related adverse events (irAEs). We also performed a review of previous case reports presenting dysautonomia during ICI therapy. Moreover, we conducted pharmacovigilance analyses using the US Food and Drug Administration Adverse Events Reporting System (FAERS) to investigate dysautonomia associated with ICI...
March 20, 2023: Journal of Neurology
https://read.qxmd.com/read/36939930/former-participation-in-professional-football-as-an-occupation-in-patients-with-isolated-rem-sleep-behavior-disorder-leading-to-a-synucleinopathy-a-case-control-study
#13
JOURNAL ARTICLE
Alejandra Collía, Alex Iranzo, Mónica Serradell, Amaia Muñoz-Lopetegi, Gerard Mayà, Joan Santamaría, Raquel Sánchez-Valle, Carles Gaig
BACKGROUND: Contact sports such as football are associated with late development of neurodegenerative diseases, in part due to the deleterious effect of repetitive head impacts during participation. Isolated REM sleep behavior disorder (IRBD) represents an early manifestation of neurodegenerative diseases including Parkinson disease (RBD) and dementia with Lewy bodies (DLB). We hypothesized that former professional football participation would be overrepresented in IRBD. OBJECTIVE: To assess former participation in professional football as an occupation in IRBD...
March 20, 2023: Journal of Neurology
https://read.qxmd.com/read/36933032/a-prospective-study-of-cellular-immune-response-to-booster-covid-19-vaccination-in-multiple-sclerosis-patients-treated-with-a-broad-spectrum-of-disease-modifying-therapies
#14
JOURNAL ARTICLE
Pascual Torres, Agustín Sancho-Saldaña, Anna Gil Sánchez, Silvia Peralta, Maria José Solana, Sofian Bakkioui, Cristina González-Mingot, Laura Quibus, Emilio Ruiz-Fernández, Eduardo San Pedro-Murillo, Luis Brieva
BACKGROUND: Most people with Multiple Sclerosis (pwMS) are subjected to immunomodulatory disease-modifying treatments (DMTs). As a result, immune responses to COVID-19 vaccinations could be compromised. There are few data on cellular immune responses to the use of COVID-19 vaccine boosters in pwMS under a broad spectrum of DMTs. METHODS: In this prospective study, we analysed cellular immune responses to SARS-CoV-2 mRNA booster vaccinations in 159 pwMS with DMT, including: ocrelizumab, rituximab, fingolimod, alemtuzumab, dimethyl fumarate, glatiramer acetate, teriflunomide, natalizumab and cladribine...
March 18, 2023: Journal of Neurology
https://read.qxmd.com/read/36933031/mutation-screening-of-aopep-variants-in-a-large-dystonia-cohort
#15
JOURNAL ARTICLE
Junyu Lin, Chunyu Li, Yiyuan Cui, Yanbing Hou, Lingyu Zhang, Ruwei Ou, Qianqian Wei, Kuncheng Liu, Rui Huang, Tianmi Yang, Yi Xiao, Qirui Jiang, Jing Yang, Xueping Chen, Huifang Shang
STUDY OBJECTIVES: Recently, AOPEP has been identified to be a novel causative gene of autosomal-recessive dystonia. However, no large cohort study has been conducted to confirm the association. We aimed to systematically evaluate the genetic associations of AOPEP with dystonia in a large Chinese dystonia cohort. METHODS: We analyzed rare variants of AOPEP in 878 dystonia patients with whole-exome sequencing. The over-representation of rare variants in patients was examined with Fisher's exact test at allele and gene levels...
March 18, 2023: Journal of Neurology
https://read.qxmd.com/read/36933030/abnormal-thalamic-functional-connectivity-correlates-with-cardiorespiratory-fitness-and-physical-activity-in-progressive-multiple-sclerosis
#16
JOURNAL ARTICLE
Francesco Romanò, Robert W Motl, Paola Valsasina, Maria Pia Amato, Giampaolo Brichetto, Nicolò Bruschi, Jeremy Chataway, Nancy D Chiaravalloti, Gary Cutter, Ulrik Dalgas, John DeLuca, Rachel Farrell, Peter Feys, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Amber Salter, Brian M Sandroff, Anthony Feinstein, Maria A Rocca, Massimo Filippi
BACKGROUND: Altered thalamic volumes and resting state (RS) functional connectivity (FC) might be associated with physical activity (PA) and cardiorespiratory fitness (CRF) in people with progressive multiple sclerosis (PMS). OBJECTIVES: To assess thalamic structural and functional alterations and investigate their correlations with PA/CRF levels in people with PMS. METHODS: Seven-day accelerometry and cardiopulmonary exercise testing were used to assess PA/CRF levels in 91 persons with PMS...
March 18, 2023: Journal of Neurology
https://read.qxmd.com/read/36917342/split-elbow-sign-in-the-pro-act-and-southern-italy-als-cohorts-a-potential-marker-of-disease-severity-and-lower-motor-neuron-involvement
#17
JOURNAL ARTICLE
Stefano Zoccolella, Giammarco Milella, Alessia Giugno, Daniele Urso, Ludovica Tamburrino, Salvatore Nigro, Valentina Gnoni, Marco Filardi, Giancarlo Logroscino
INTRODUCTION: Split phenomena in ALS refers to the preferential dysfunction of some groups of muscles over others. The split-elbow sign (SE) is characterized by the predominant weakness of the biceps compared to the triceps, but available results are conflicting. OBJECTIVES: To evaluate the prevalence of the SE in two independent cohorts: the randomized controlled trial-based PRO-ACT cohort (n = 500) and a monocentric cohort of patients with ALS from Southern Italy (n = 144); to investigate the demographic and clinical variables associated with the SE sign...
March 14, 2023: Journal of Neurology
https://read.qxmd.com/read/36914787/the-influence-of-culture-and-cognitive-reserve-on-the-clinical-presentation-of-behavioural-variant-frontotemporal-dementia
#18
JOURNAL ARTICLE
A Skeggs, G Wei, R Landin-Romero, J R Hodges, O Piguet, Fiona Kumfor
Characterisation of the clinical profile of behavioural-variant frontotemporal dementia (bvFTD) has predominantly been based on Western samples. Some small studies have suggested that the clinical profile may differ in culturally and linguistically diverse populations. Additionally, there is evidence that patients from non-English speaking backgrounds may have more cognitive reserve, allowing them to tolerate more disease pathology before clinical symptoms emerge. This study aims to characterise the clinical profiles of patients with bvFTD from culturally diverse backgrounds...
March 14, 2023: Journal of Neurology
https://read.qxmd.com/read/36913042/correction-to-hypocortisolism-as-an-unusual-but-treatable-cause-of-dystonia%C3%A2-parkinsonism
#19
Clément Desjardins, Marie Mongin, Astrid de Liège, Bertrand Degos
No abstract text is available yet for this article.
March 13, 2023: Journal of Neurology
https://read.qxmd.com/read/36913041/correction-to-correlation-between-clinical-phenotype-and-electromyographic-parameters-in-amyotrophic-lateral-sclerosis
#20
Eleonora Colombo, Alberto Doretti, Francesco Scheveger, Alessio Maranzano, Giulia Pata, Delia Gagliardi, Megi Meneri, Stefano Messina, Federico Verde, Claudia Morelli, Stefania Corti, Luca Maderna, Vincenzo Silani, Nicola Ticozzi
No abstract text is available yet for this article.
March 13, 2023: Journal of Neurology
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