journal
https://read.qxmd.com/read/33452932/clinical-features-and-outcome-of-patients-with-primary-central-nervous-system-lymphoma-admitted-to-the-intensive-care-unit-a-french-national-expert-center-experience
#1
Maxens Decavèle, Aliénor Dreyfus, Nicolas Gatulle, Nicolas Weiss, Caroline Houillier, Sophie Demeret, Julien Mayaux, Isabelle Rivals, Martin Dres, Julie Delemazure, Elise Morawiec, Charles-Edouard Luyt, Khe Hoang-Xuan, Sylvain Choquet, Thomas Similowski, Alexandre Demoule
INTRODUCTION: To describe the reasons for intensive care unit (ICU) admission and to evaluate the outcomes and prognostic factors of patients with primary central nervous system lymphoma (PCNSL) admitted to the ICU. PATIENTS AND METHODS: Retrospective observational cohort study of 101 PCNSL patients admitted to 3 ICUs over a two-decade period. RESULTS: Acute respiratory failure, mainly secondary to aspiration pneumonia and Pneumocystis jirovecii pneumonia, was the leading reason for ICU admission (33%)...
January 16, 2021: Journal of Neurology
https://read.qxmd.com/read/33449202/telerehabilitation-in-response-to-constrained-physical-distance-an-opportunity-to-rethink-neurorehabilitative-routines
#2
REVIEW
Arturo Nuara, Maddalena Fabbri-Destro, Emilia Scalona, Stefano Elio Lenzi, Giacomo Rizzolatti, Pietro Avanzini
Ensuring proper dosage of treatment and repetition over time is a major challenge in neurorehabilitation. However, a requirement of physical distancing to date compromises their achievement. While mostly associated to COVID-19, physical distancing is not only required in a pandemic scenario, but also advised for several clinical conditions (e.g. immunocompromised individuals) or forced for specific social contexts (e.g. people living in remote areas worldwide). All these contexts advocate for the implementation of alternative healthcare models...
January 15, 2021: Journal of Neurology
https://read.qxmd.com/read/33442772/decreased-inflammatory-cytokine-production-of-antigen-specific-cd4-t-cells-in-nmda-receptor-encephalitis
#3
Le-Minh Dao, Marie-Luise Machule, Petra Bacher, Julius Hoffmann, Lam-Thanh Ly, Florian Wegner, Alexander Scheffold, Harald Prüss
Anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis is the most common autoimmune encephalitis with psychosis, amnesia, seizures and dyskinesias. The disease is mediated by pathogenic autoantibodies against the NR1 subunit that disrupt NMDAR function. Antibody infusion into mouse brains can recapitulate encephalitis symptoms, while active immunization resulted also in strong T cell infiltration into the hippocampus. However, whether T cells react against NMDAR and their specific contribution to disease development are poorly understood...
January 13, 2021: Journal of Neurology
https://read.qxmd.com/read/33439329/the-use-of-calcitonin-gene-related-peptide-monoclonal-antibodies-in-the-difficult-to-treat-migraine-population
#4
T Cosslett, C Mitchell
No abstract text is available yet for this article.
January 13, 2021: Journal of Neurology
https://read.qxmd.com/read/33439328/long-term-psychosocial-outcome-following-mild-traumatic-brain-injury-and-minor-stroke-a-direct-longitudinal-comparison
#5
Daan P J Verberne, Rudolf W H M Ponds, Mariëlle E A L Kroese, Melloney L M Wijenberg, Dennis G Barten, Raphaël Pasmans, Julie Staals, Caroline M van Heugten
BACKGROUND AND PURPOSE: Research suggests comparable long-term psychosocial outcomes following mild traumatic brain injury (mTBI) and minor stroke, but no direct comparison has been made. This study aimed to directly compare psychosocial outcome over time in persons with mTBI and minor stroke. METHODS: In this multicenter, prospective longitudinal cohort study, community-dwelling persons with mTBI (n = 182) and minor stroke (n = 48) were assessed at 6 weeks, 3, 6 and 12 months post-injury...
January 13, 2021: Journal of Neurology
https://read.qxmd.com/read/33439327/cardiovascular-magnetic-resonance-imaging-and-its-role-in-the-investigation-of-stroke-an-update
#6
Ana Catarina Fonseca, José M Ferro, Ana G Almeida
Recent advances in complementary diagnostic exams have helped to clarify stroke etiology, not only by helping to confirm established stroke causes but also by unveiling new possible stroke mechanisms. Etiological investigation for cardioembolic stroke has benefited in the last years from information provided by studies analysing serum biomarkers, heart rhythm monitoring and imaging methods like cardiovascular magnetic resonance (CMR) imaging. CMR has been particularly important for the characterization of possible new cardioembolic stroke mechanisms including atrial cardiomyopathy, silent myocardial infarction and cardiomyopathies...
January 13, 2021: Journal of Neurology
https://read.qxmd.com/read/33438076/central-and-peripheral-nervous-system-complications-of-covid-19-a-prospective-tertiary-center-cohort-with-3-month-follow-up
#7
Vardan Nersesjan, Moshgan Amiri, Anne-Mette Lebech, Casper Roed, Helene Mens, Lene Russell, Lise Fonsmark, Marianne Berntsen, Sigurdur Thor Sigurdsson, Jonathan Carlsen, Annika Reynberg Langkilde, Pernille Martens, Eva Løbner Lund, Klaus Hansen, Bo Jespersen, Marie Norsker Folke, Per Meden, Anne-Mette Hejl, Christian Wamberg, Michael E Benros, Daniel Kondziella
OBJECTIVE: To systematically describe central (CNS) and peripheral (PNS) nervous system complications in hospitalized COVID-19 patients. METHODS: We conducted a prospective, consecutive, observational study of adult patients from a tertiary referral center with confirmed COVID-19. All patients were screened daily for neurological and neuropsychiatric symptoms during admission and discharge. Three-month follow-up data were collected using electronic health records...
January 13, 2021: Journal of Neurology
https://read.qxmd.com/read/33423129/higher-midlife-caide-score-is-associated-with-increased-brain-atrophy-in-a-cohort-of-cognitively-healthy-middle-aged-individuals
#8
Xulin Liu, Maria-Eleni Dounavi, Karen Ritchie, Katie Wells, Craig W Ritchie, Li Su, Graciela Muniz-Terrera, John T O'Brien
BACKGROUND: Structural brain changes associated with Alzheimer's disease (AD) can occur decades before the onset of symptoms. The Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) score has been suggested to be associated with accelerated brain atrophy in middle-aged subjects but the regional specificity of atrophic areas remains to be elucidated. METHODS: 3T T1-weighted magnetic resonance imaging scans of 160 cognitively healthy middle-aged participants (mean age = 52) in the PREVENT-Dementia cohort, from baseline and from follow-up after 2 years, were examined...
January 9, 2021: Journal of Neurology
https://read.qxmd.com/read/33417007/correction-to-refractory-anti%C3%A2-nmdar-encephalitis-successfully-treated-with-bortezomib-and-associated-movements-disorders-controlled-with-tramadol-a-case-report-with-literature-review
#9
Serena Marita Lazzarin, Marco Vabanesi, Giordano Cecchetti, Raffaella Fazio, Giovanna Franca Fanelli, Maria Antonietta Volonté, Angela Genchi, Antonino Giordano, Vittorio Martinelli, Sergio Colombo, Paolo Beccaria, Milena Mucci, Jacopo Peccatori, Massimo Filippi, Fabio Minicucci
No abstract text is available yet for this article.
January 8, 2021: Journal of Neurology
https://read.qxmd.com/read/33417006/bilateral-sequential-sudden-sensorineural-hearing-loss-in-protein-s-deficiency
#10
LETTER
Euyhyun Park, Sun-Uk Lee, Jeong-Yoon Choi, Gi Jung Im, Sungwook Yu, Ji-Soo Kim
No abstract text is available yet for this article.
January 8, 2021: Journal of Neurology
https://read.qxmd.com/read/33417005/head-tremor-and-pain-in-cervical-dystonia
#11
Jeanne P Vu, Ha Yeon Lee, Qiyu Chen, Elizabeth Cisneros, Richard L Barbano, Christopher G Goetz, Joseph Jankovic, Hyder A Jinnah, Joel S Perlmutter, Brian D Berman, Mark I Appelbaum, Glenn T Stebbins, Cynthia L Comella, David A Peterson
BACKGROUND: Although head tremor (HT) and pain are prevalent in cervical dystonia (CD), their joint relationship to phenotypic features of focal dystonia remains unclear. OBJECTIVES: We examined how severity of HT and pain are associated with age of CD onset and duration, and whether HT subtypes ("jerky" or "regular") exhibit distinct relationships between severity of HT and pain. METHODS: The severity of HT and pain were assessed with the Toronto Western Spasmodic Torticollis Rating Scale in retrospective review of 188 CD patients recruited through the Dystonia Coalition...
January 8, 2021: Journal of Neurology
https://read.qxmd.com/read/33417004/metachromatic-leukodystrophy-with-late-adult-onset-diagnostic-clues-and-differences-from-other-genetic-leukoencephalopathies-with-dementia
#12
LETTER
Chiara Benzoni, Marco Moscatelli, Silvia Fenu, Anna Venerando, Ettore Salsano
No abstract text is available yet for this article.
January 8, 2021: Journal of Neurology
https://read.qxmd.com/read/33417003/effect-of-melatonin-supplementation-on-sleep-quality-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#13
REVIEW
Gholami Fatemeh, Moradi Sajjad, Rasaei Niloufar, Soveid Neda, Setayesh Leila, Mirzaei Khadijeh
BACKGROUND: The Present study was conducted to systematically review the effect of the melatonin on sleep quality. We summarized evidence from randomized clinical trials (RCTs) that investigated the effects of melatonin on sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) in adults with various diseases. METHODS: The literature searches of English publications in MEDLINE and EMBASE databases were performed up June 2020. Results were summarized as mean differences (MD) with 95% confidence intervals (CI) using random effects model (DerSimonian-Laird method)...
January 8, 2021: Journal of Neurology
https://read.qxmd.com/read/33417002/william-gordon-lennox-1884-1960
#14
Mattia Rosso, Duong Chu, Jonathan D Santoro
No abstract text is available yet for this article.
January 8, 2021: Journal of Neurology
https://read.qxmd.com/read/33417001/expanding-the-clinical-spectrum-of-stip1-homology-and-u-box-containing-protein-1-associated-ataxia
#15
Jean-Marie Ravel, Mehdi Benkirane, Nadège Calmels, Cecilia Marelli, Fabienne Ory-Magne, Claire Ewenczyk, Yosra Halleb, François Tison, Claire Lecocq, Guillaume Pische, Philippe Casenave, Annabelle Chaussenot, Solène Frismand, Louise Tyvaert, Lise Larrieu, Morgane Pointaux, Nathalie Drouot, Carine Bossenmeyer-Pourié, Abderrahim Oussalah, Jean-Louis Guéant, Bruno Leheup, Céline Bonnet, Mathieu Anheim, Christine Tranchant, Laëtitia Lambert, Jamel Chelly, Michel Koenig, Mathilde Renaud
BACKGROUND: STUB1 has been first associated with autosomal recessive (SCAR16, MIM# 615768) and later with dominant forms of ataxia (SCA48, MIM# 618093). Pathogenic variations in STUB1 are now considered a frequent cause of cerebellar ataxia. OBJECTIVE: We aimed to improve the clinical, radiological, and molecular delineation of SCAR16 and SCA48. METHODS: Retrospective collection of patients with SCAR16 or SCA48 diagnosed in three French genetic centers (Montpellier, Strasbourg and Nancy)...
January 8, 2021: Journal of Neurology
https://read.qxmd.com/read/33417000/longitudinal-cognitive-and-functional-changes-in-primary-progressive-aphasia
#16
David Foxe, Muireann Irish, Anne Hu, James Carrick, John R Hodges, Rebekah M Ahmed, James R Burrell, Olivier Piguet
OBJECTIVE: The variants of primary progressive aphasia (PPA) are predominantly diagnosed on the basis of specific profiles of language impairments. Deficits in other cognitive domains and their evolution over time are less well documented. This study examined the cognitive profiles of the PPA variants over time and determined the contribution of cognition on functional capacity. METHODS: Longitudinal performance on the Addenbrooke's Cognitive Examination-III (ACE-III) total and cognitive subdomains were investigated in 147 PPA individuals (41 logopenic [lv-PPA], 44 non-fluent [nfv-PPA], and 62 semantic variants [sv-PPA])...
January 8, 2021: Journal of Neurology
https://read.qxmd.com/read/33416999/rituximab-for-the-treatment-of-multiple-sclerosis-a-review
#17
REVIEW
Clara Grazia Chisari, Eleonora Sgarlata, Sebastiano Arena, Simona Toscano, Maria Luca, Francesco Patti
In the last decades, evidence suggesting the direct or indirect involvement of B cells on multiple sclerosis (MS) pathogenesis has accumulated. The increased amount of data on the efficacy and safety of B-cell-depleting therapies from several studies has suggested the addition of these drugs as treatment options to the current armamentarium of disease modifying therapies (DMTs) for MS. Particularly, rituximab (RTX), a chimeric monoclonal antibody directed at CD20 positive B lymphocytes resulting in cell-mediated apoptosis, has been demonstrated to reduce inflammatory activity, incidence of relapses and new brain lesions on magnetic resonance imaging (MRI) in patients with relapsing-remitting MS (RRMS)...
January 8, 2021: Journal of Neurology
https://read.qxmd.com/read/33416998/impact-of-comorbid-sj%C3%A3-gren-syndrome-in-anti-aquaporin-4-antibody-positive-neuromyelitis-optica-spectrum-disorders
#18
Tetsuya Akaishi, Toshiyuki Takahashi, Kazuo Fujihara, Tatsuro Misu, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima
BACKGROUND: Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune neurological diseases of the central nervous system, which are characterized by the presence of serum anti-aquaporin-4 autoantibodies (AQP4-IgG). An association between Sjögren syndrome (SjS) and AQP4-IgG-positive NMOSD has been proposed, but the rate of coexistence has not been determined. METHODS: In this study, 4,447 patients suspected of having NMOSD with acute neurological episodes were evaluated for the positivity of serum AQP4-IgG, serum SS-A/Ro antibody, and the presence of SjS-related symptoms (dry eye, dry mouth)...
January 8, 2021: Journal of Neurology
https://read.qxmd.com/read/33410930/a-critical-review-of-the-pharmacological-treatment-of-rem-sleep-behavior-disorder-in-adults-time-for-more-and-larger-randomized-placebo-controlled-trials
#19
REVIEW
Moran Gilat, Nathaniel S Marshall, Dries Testelmans, Bertien Buyse, Simon J G Lewis
Rapid Eye Movement sleep behavior disorder (RBD) is a parasomnia causing sufferers to physically act out their dreams. These behaviors can disrupt sleep and sometimes lead to injuries in patients and their bed-partners. Clonazepam and melatonin are the first-line pharmacological treatment options for RBD based on direct uncontrolled clinical observations and very limited double-blind placebo-controlled trials. Given the risk for adverse outcomes, especially in older adults, it is of great importance to assess the existing level of evidence for the use of these treatments...
January 7, 2021: Journal of Neurology
https://read.qxmd.com/read/33409603/wearables-in-the-home-based-assessment-of-abnormal-movements-in-parkinson-s-disease-a-systematic-review-of-the-literature
#20
REVIEW
Stefania Ancona, Francesca D Faraci, Elina Khatab, Luigi Fiorillo, Oriella Gnarra, Tobias Nef, Claudio L A Bassetti, Panagiotis Bargiotas
At present, the standard practices for home-based assessments of abnormal movements in Parkinson's disease (PD) are based either on subjective tools or on objective measures that often fail to capture day-to-day fluctuations and long-term information in real-life conditions in a way that patient's compliance and privacy are secured. The employment of wearable technologies in PD represents a great paradigm shift in healthcare remote diagnostics and therapeutics monitoring. However, their applicability in everyday clinical practice seems to be still limited...
January 6, 2021: Journal of Neurology
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