journal
MENU ▼
Read by QxMD icon Read
search

Journal of Neurology

journal
https://read.qxmd.com/read/31102021/factors-that-predict-diagnostic-stability-in-neurodegenerative-dementia
#1
David C Perry, Samir Datta, Zachary A Miller, Katherine P Rankin, Maria Luisa Gorno-Tempini, Joel H Kramer, Howard J Rosen, William W Seeley, Bruce L Miller
OBJECTIVE: To determine the frequency and characteristics of clinical diagnostic change in frontotemporal dementia (FTD)-spectrum syndromes and Alzheimer's disease (AD)-type dementia. METHODS: We reviewed records and categorized diagnostic changes in patients seen ≥ 2 times with behavioral variant FTD (bvFTD, n = 99), nonfluent and semantic variant primary progressive aphasia (nfvPPA, n = 32; svPPA, n = 59), corticobasal syndrome (CBS, n = 40), progressive supranuclear palsy-Richardson syndrome (PSP-RS, n = 34), and AD-type dementia (n = 49)...
May 17, 2019: Journal of Neurology
https://read.qxmd.com/read/31102020/vestibular-rehabilitation-therapy-in-europe-chances-and-challenges
#2
LETTER
Klaus Jahn, Christophe Lopez, Andreas Zwergal, Oz Zur, Ondrej Cakrt, Silvy Kellerer, Hassen Kerkeni, Fredrik Tjernström, Dara Meldrum
No abstract text is available yet for this article.
May 17, 2019: Journal of Neurology
https://read.qxmd.com/read/31102019/fear-of-heights-in-virtual-reality-saturates-20-to-40-m-above-ground
#3
Wuehr Max, Breitkopf Katharina, Decker Julian, Ibarra Gerardo, Huppert Doreen, Brandt Thomas
Recent epidemiological studies indicate that about one-third of the general population suffers from a more or less disabling height intolerance, with a relevant impact on quality of life in many of them. Acrophobia, the most severe form of visual height intolerance, has a life-time prevalence of around 5%. Although it is commonly believed that fear of heights should continuously aggravate with increasing elevation, this issue has not been systematically investigated yet. Here, we examined this topic using immersive virtual reality, an established tool in therapy for fear of heights, that allows to flexibly manipulate height stimuli...
May 17, 2019: Journal of Neurology
https://read.qxmd.com/read/31098803/ji%C3%A5-%C3%A3-proch%C3%A3-ska-1749-1820
#4
Michał K Owecki, Pilar León-Sanz
No abstract text is available yet for this article.
May 17, 2019: Journal of Neurology
https://read.qxmd.com/read/31093755/a-randomized-controlled-trial-on-the-efficacy-safety-and-pharmacokinetics-of-metformin-in-severe-traumatic-brain-injury
#5
Ali Taheri, Mahdi Emami, Erfan Asadipour, Sara Kasirzadeh, Mohammad-Reza Rouini, Atabak Najafi, Ramin Heshmat, Mohammad Abdollahi, Mojtaba Mojtahedzadeh
OBJECTIVE: Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide. Metformin is reported to have pleiotropic neuroprotective effects through anti-inflammatory, antioxidative, and anti-ischemic activity, and improvements in vascular hemodynamics and endothelial function. The aim of this study is to examine the efficacy and safety of metformin therapy in severe TBI patients. METHODS: This single-blind, parallel-group, randomized controlled trial enrolled adult TBI patients...
May 16, 2019: Journal of Neurology
https://read.qxmd.com/read/31089861/relevance-of-anti-hnk1-antibodies-in-the-management-of-anti-mag-neuropathies
#6
Emilien Delmont, Shahram Attarian, Jean-Christophe Antoine, Stephane Paul, Jean Philippe Camdessanché, Aude-Marie Grapperon, Alexandre Brodovich, Jose Boucraut
INTRODUCTION: In peripheral neuropathies with antibodies against Myelin Associated Glycoprotein (MAG), an IgM monoclonal gammopathy recognizes a specific epitope called Human Natural Killer 1 (HNK1) shared by NK lymphocytes and several components of the peripheral nerve myelin. Recently an ELISA test has been developed to detect antibodies against HNK1 epitope. Objectives were to determine the usefulness of this assay in the management of anti-MAG neuropathy. METHODS: Anti-HNK1 antibodies were assessed with the GanglioCombi™ MAG ELISA test (Buhlmann) in 41 anti-MAG neuropathies and in 118 controls: 34 chronic inflammatory demyelinating polyradiculoneuropathies, 3 Miller Fisher syndromes, 12 sensory neuronopathies, 63 length-dependent axonal sensory polyneuropathies, 6 healthy controls...
May 14, 2019: Journal of Neurology
https://read.qxmd.com/read/31089860/amyotrophic-lateral-sclerosis-type-8-is-not-a-pure-motor-disease-evidence-from-a-neuropsychological-and-behavioural-study
#7
Cássia de Alcântara, Marcelo Maroco Cruzeiro, Marcondes C França, Sarah Teixeira Camargos, Leonardo Cruz de Souza
OBJECTIVE: Amyotrophic lateral sclerosis type 8 (ALS8) is a familial form of motor neuron disease, with predominance of lower motor neuron degeneration, and is caused by mutation of the vesicle-associated membrane protein-associated protein B (VAPB). We aimed to compare the cognitive profile of patients with ALS8 and healthy controls (HC), and to screen for behavioural features in ALS8 patients. METHODS: The sample was composed of ALS8 patients (n = 22; 14 men; median age 48 years old; median disease duration 6...
May 14, 2019: Journal of Neurology
https://read.qxmd.com/read/31087161/survey-of-motion-sickness-susceptibility-in-children-and-adolescents-aged-3-months-to-18-years
#8
Doreen Huppert, Eva Grill, Thomas Brandt
We conducted two representative, cross-sectional, population-based surveys on the susceptibility to motion sickness (MSS) in childhood: One was targeted at parents with children aged 6 months to 18 years (7569 households approached) and the other at parents with children aged 3 months to 5 years (12,720 households approached). In both surveys 3285 parents provided information on 5041 children. The main findings in the first survey were: 369 children (9.2%) were susceptible to motion sickness with a slight female preponderance, and in the second study 16 (1...
May 13, 2019: Journal of Neurology
https://read.qxmd.com/read/31087160/neurological-adverse-events-post-allogeneic-hematopoietic-cell-transplantation-major-determinants-of-morbidity-and-mortality
#9
Ioanna Sakellari, Eleni Gavriilaki, Sotirios Papagiannopoulos, Maria Gavriilaki, Ioannis Batsis, Despina Mallouri, Anna Vardi, Varnavas Constantinou, Marianna Masmanidou, Evangelia Yannaki, Christos Smias, Triantafyllos Geroukis, Dimitrios Kazis, Vasileios Kimiskidis, Achilles Anagnostopoulos
BACKGROUND: Despite advances in the field, diagnosis and management of the wide spectrum of neurological events post allogeneic hematopoietic cell transplantation (alloHCT) remain challenging. Therefore, we investigated their incidence, diagnosis, management and long-term prognosis in alloHCT recipients. METHODS: We retrospectively recorded data from consecutive alloHCT recipients with or without neurological complications in our center. RESULTS: Among 758 alloHCT recipients, 127 (16...
May 13, 2019: Journal of Neurology
https://read.qxmd.com/read/31076878/amyotrophy-cerebellar-impairment-and-psychiatric-disease-are-the-main-symptoms-in-a-cohort-of-14-czech-patients-with-the-late-onset-form-of-tay-sachs-disease
#10
Helena Jahnová, Helena Poupětová, Jitka Jirečková, Hana Vlášková, Eva Košťálová, Radim Mazanec, Alena Zumrová, Petr Mečíř, Zuzana Mušová, Martin Magner
BACKGROUND: Tay-Sachs disease (TSD) is an inherited neurodegenerative disorder caused by a lysosomal β-hexosaminidase A deficiency due to mutations in the HEXA gene. The late-onset form of disease (LOTS) is considered rare, and only a limited number of cases have been reported. The clinical course of LOTS differs substantially from classic infantile TSD. METHODS: Comprehensive data from 14 Czech patients with LOTS were collated, including results of enzyme assays and genetic analyses...
May 10, 2019: Journal of Neurology
https://read.qxmd.com/read/31076877/neuronal-loss-or-dysfunction-in-patients-with-early-lyme-neuroborreliosis-a-proton-magnetic-resonance-spectroscopy-study-of-the-brain
#11
Adam Garkowski, Bożena Kubas, Marcin Hładuński, Joanna Zajkowska, Olga Zajkowska, Dorota Jurgilewicz, Radosław Zawadzki, Ewa Garkowska, Sławomir Pancewicz, Urszula Łebkowska
BACKGROUND: We hypothesized that since Borrelia burgdorferi causes systemic inflammation and infects the brain, it may lead to alterations in cerebral metabolism, as measured by 1 H-magnetic resonance spectroscopy (1 H-MRS). The purpose of our study was to determine whether 1 H-MRS could detect brain metabolite alterations in patients with early Lyme neuroborreliosis (LNB) in normal-appearing brain tissue on the conventional magnetic resonance imaging (MRI). METHODS: Twenty-six patients diagnosed with early LNB and twenty-six healthy volunteers as a control group have been involved in the study...
May 10, 2019: Journal of Neurology
https://read.qxmd.com/read/31076876/electrical-brain-stimulation-of-the-parietal-lobe-impairs-the-perception-of-verticality
#12
LETTER
O Kremmyda, V Kirsch, S Bardins, H Lohr, C Vollmar, S Noachtar, M Dieterich
No abstract text is available yet for this article.
May 10, 2019: Journal of Neurology
https://read.qxmd.com/read/31076875/real-world-pharmacological-treatment-patterns-of-patients-with-young-onset-parkinson-s-disease-in-japan-a-medical-claims-database-analysis
#13
Sachiko Kasamo, Masato Takeuchi, Masashi Ikuno, Yohei Kawasaki, Shiro Tanaka, Ryosuke Takahashi, Koji Kawakami
INTRODUCTION: Young-onset Parkinson's disease is reported to comprise 5-10% of all Parkinson's disease cases; however, as physicians encounter a limited number of these patients, their treatment patterns are still unclear. METHODS: We performed a descriptive study using the large Japanese medical claims database to describe the epidemiology and real-world pharmacological treatment patterns of newly diagnosed patients with young-onset Parkinson's disease. Patients aged 21-50 years in whom Parkinson's disease was newly diagnosed between January 1, 2005 and March 31, 2016 were included...
May 10, 2019: Journal of Neurology
https://read.qxmd.com/read/31073716/does-the-mds-updrs-provide-the-precision-to-assess-progression-in-early-parkinson-s-disease-learnings-from-the-parkinson-s-progression-marker-initiative-cohort
#14
Antoine Regnault, Babak Boroojerdi, Juliette Meunier, Massimo Bani, Thomas Morel, Stefan Cano
OBJECTIVES: Developing disease modifying therapies for Parkinson's disease (PD) calls for outcome measurement strategies focused on characterizing early stage disease progression. We explored the psychometric evidence for using the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part II (patient motor experience of daily living) and part III (clinician motor examination) in this context. METHODS: MDS-UPDRS-II and -III data were collected at screening, month 12, and month 24 from 384 early stage PD patients (diagnosis ≤ 2 years; Hoehn and Yahr stage 1/2) in the Parkinson's Progression Markers Initiative (PPMI) study...
May 9, 2019: Journal of Neurology
https://read.qxmd.com/read/31073715/selective-suppression-of-the-vestibulo-ocular-reflex-during-human-locomotion
#15
Haike Dietrich, Max Wuehr
INTRODUCTION: In lower vertebrates, gaze stabilization during locomotion is at least partially driven by a direct coupling of spinal locomotor commands with extraocular motor signals. To what extent locomotor feed-forward mechanisms contribute to gaze stabilization during human locomotion is yet unknown. In principle, the feasibility of a feed-forward regulation of gaze during locomotion should critically depend on the spatiotemporal coupling between body and head kinematics and hence the internal predictability of head movements (HMP)...
May 9, 2019: Journal of Neurology
https://read.qxmd.com/read/31073714/intact-vestibular-function-is-relevant-for-anxiety-related-to-vertigo
#16
LETTER
J Decker, K Limburg, P Henningsen, C Lahmann, T Brandt, Marianne Dieterich
No abstract text is available yet for this article.
May 9, 2019: Journal of Neurology
https://read.qxmd.com/read/31069529/multi-gene-testing-in-neurological-disorders-showed-an-improved-diagnostic-yield-data-from-over-1000-indian-patients
#17
Aparna Ganapathy, Avshesh Mishra, Megha Rani Soni, Priyanka Kumar, Mukunth Sadagopan, Anil Vittal Kanthi, Irene Rosetta Pia Patric, Sobha George, Aparajit Sridharan, T C Thyagarajan, S L Aswathy, H K Vidya, Swathi M Chinnappa, Swetha Nayanala, Manasa B Prakash, Vijayashree G Raghavendrachar, Minothi Parulekar, Vykuntaraju K Gowda, Sheela Nampoothiri, Ramshekhar N Menon, Divya Pachat, Vrajesh Udani, Neeta Naik, Mahesh Kamate, A Radha Rama Devi, P A Mohammed Kunju, Mohandas Nair, Anaita Udwadia Hegde, M Pradeep Kumar, Soumya Sundaram, Preetha Tilak, Ratna D Puri, Krati Shah, Jayesh Sheth, Qurratulain Hasan, Frenny Sheth, Pooja Agrawal, Shanmukh Katragadda, Vamsi Veeramachaneni, Vijay Chandru, Ramesh Hariharan, Ashraf U Mannan
BACKGROUND: Neurological disorders are clinically heterogeneous group of disorders and are major causes of disability and death. Several of these disorders are caused due to genetic aberration. A precise and confirmatory diagnosis in the patients in a timely manner is essential for appropriate therapeutic and management strategies. Due to the complexity of the clinical presentations across various neurological disorders, arriving at an accurate diagnosis remains a challenge. METHODS: We sequenced 1012 unrelated patients from India with suspected neurological disorders, using TruSight One panel...
May 8, 2019: Journal of Neurology
https://read.qxmd.com/read/31069528/seizures-and-epilepsy-in-multiple-sclerosis-epidemiology-and-prognosis-in-a-large-tertiary-referral-center
#18
Lisa Langenbruch, Julia Krämer, Sati Güler, Gabriel Möddel, Sophia Geßner, Nico Melzer, Christian E Elger, Heinz Wiendl, Thomas Budde, Sven G Meuth, Stjepana Kovac
BACKGROUND: Seizures and epilepsy may substantially add to the burden of disease in multiple sclerosis (MS), whereas the exact prevalence and prognosis of seizures and epilepsy in patients with MS remains largely unknown. OBJECTIVES: We aimed to investigate the epidemiology and prognosis of seizures and epilepsy in MS. METHODS: We retrospectively analyzed a cohort of 4078 MS patients from a single tertiary referral clinic. RESULTS: After excluding 37 patients with unconfirmed MS and alternative seizure etiologies, we found seizures attributable to MS in 1...
May 8, 2019: Journal of Neurology
https://read.qxmd.com/read/31065784/video-head-impulse-test-contributes-to-susac-syndrome-diagnosis
#19
LETTER
M Marrodan, A Laffue, M P Fiol, J Correale, F Gualtieri
No abstract text is available yet for this article.
May 7, 2019: Journal of Neurology
https://read.qxmd.com/read/31065783/idiopathic-acute-high-tone-sensorineural-hearing-loss-accompanied-by-vertigo-vestibulo-cochlear-artery-syndrome-consideration-based-on-vemp-and-vhit
#20
LETTER
Toshihisa Murofushi, Masahito Tsubota, Daiji Suzuki
No abstract text is available yet for this article.
May 7, 2019: Journal of Neurology
journal
journal
20158
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"