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Journals Journal of the National Cancer...

Journal of the National Cancer Institute

https://read.qxmd.com/read/38908000/when-the-somatic-genome-informs-the-germline-the-example-of-tp53
#1
EDITORIAL
Payal P Khincha, Sharon A Savage
No abstract text is available yet for this article.
June 22, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38902947/differences-in-tumor-associated-t-cell-receptor-repertoires-between-early-onset-and-average-onset-colorectal-cancer
#2
JOURNAL ARTICLE
Ya-Yu Tsai, Kanika G Nair, Shimoli V Barot, Shao Xiang, Suneel Kamath, Marilena Melas, Christopher P Walker, Raghvendra Srivastava, Nicole Osborne, Timothy A Chan, Jonathan B Mitchem, Joseph D Bonner, Kevin J McDonnell, Gregory E Idos, Rebeca Sanz-Pamplona, Joel K Greenson, Hedy S Rennert, Gad Rennert, Victor Moreno, Stephen B Gruber, Alok A Khorana, David Liska, Stephanie L Schmit
The incidence of colorectal cancer (CRC) among individuals younger than age 50 (early onset CRC; EOCRC) has substantially increased, yet the etiology and molecular mechanisms underlying this alarming rise remain unclear. We compared tumor-associated T cell repertoires between EOCRC and average-onset CRC (AOCRC) to uncover potentially unique immune microenvironment-related features by age of onset. Our discovery cohort included 242 patients who underwent surgical resection at Cleveland Clinic from 2000 to 2020...
June 20, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38889303/predicting-prostate-cancer-grade-reclassification-on-active-surveillance-using-a-deep-learning-based-grading-algorithm
#3
JOURNAL ARTICLE
Chien-Kuang C Ding, Zhuo Tony Su, Erik Erak, Lia DePaula Oliveira, Daniela C Salles, Yuezhou Jing, Pranab Samanta, Saikiran Bonthu, Uttara Joshi, Chaith Kondragunta, Nitin Singhal, Angelo M De Marzo, Bruce J Trock, Christian P Pavlovich, Claire M de la Calle, Tamara L Lotan
Deep learning (DL)-based algorithms to determine prostate cancer (PCa) Grade Group (GG) on biopsy slides have not been validated by comparison to clinical outcomes. We used a DL-based algorithm, AIRAProstate, to re-grade initial prostate biopsies in two independent PCa active surveillance (AS) cohorts. In a cohort initially diagnosed with GG1 PCa using only systematic biopsies (n = 138), upgrading of the initial biopsy to ≥GG2 by AIRAProstate was associated with rapid or extreme grade reclassification on AS (odds ratio 3...
June 18, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38889290/re-dietary-interventions-in-cancer-a-systematic-review-of-all-randomized-controlled-trials
#4
JOURNAL ARTICLE
Kuang-Yi Wen, Sara E Burke, Jenna L Jacoby, Jessica Liang, Nicole L Simone
No abstract text is available yet for this article.
June 18, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38885413/metabolic-dysregulation-and-cancer-risk-program-medoc-a-transdisciplinary-approach-to-obesity-associated-cancers
#5
JOURNAL ARTICLE
Tram Kim Lam, Phil Daschner, Naoko Ishibe, Anil Wali, Kara Hall, Susan Czajkowski, Somdat Mahabir, Joanna M Watson, Linda Nebeling, Sharon Ross, Edward Sauter
With the escalating prevalence of obesity, the association between obesity and cancer is a growing public health concern. Obesity will soon surpass tobacco smoking as the most important preventable cause of cancer. Obesity-driven mechanisms can alter cell functions to induce metabolic changes, chronic inflammation, and insulin resistance that are believed to contribute to cancer risk and development; yet the specific underlying biological mechanisms of obesity-related cancer development are largely unknown...
June 17, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38885371/efficacy-and-safety-of-personalized-optimal-pd-l-1-combinations-in-advanced-nsclc-a-network-meta-analysis
#6
JOURNAL ARTICLE
Xianjing Chu, Wentao Tian, Jiaoyang Ning, Rongrong Zhou
INTRODUCTION: Programmed death 1 (PD-1)/programmed death 1 ligand 1 (PD-L1)-directed immunotherapy has revolutionized the treatments for advanced non-small cell lung cancer (NSCLC), whereas the optimal therapeutic combinations remain uncertain. METHODS: Our study encompassed phase Ⅱ/III randomized controlled trials (RCTs) that involved anti-PD-(L)1-based therapies for stage-IV NSCLC. The primary outcomes included overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and incidences of adverse events (AEs)...
June 17, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38876978/the-state-of-cancer-focused-community-outreach-and-engagement-coe-reflections-of-black-coe-directors
#7
JOURNAL ARTICLE
Kimlin Tam Ashing, Nadine J Barrett, Monica L Baskin, Lisa Carter-Bawa, Timiya S Nolan, Folakemi T Odedina, Kim F Rhoads, Vanessa B Sheppard, Charnita Zeigler-Johnson, Hayley S Thompson
The requirement of community outreach and engagement (COE) as a major component of the National Cancer Institute (NCI) Cancer Center Support Grant has had enormous impact on the way NCI-designated cancer centers identify, investigate, and address the needs of their catchment area (CA) communities. Given the wide-ranging diversity of our nation, COE's scope of work is extremely demanding and complex. Yet, COE is often marginalized and viewed as void of scientific methods when, in fact, it requires specialized scientific knowledge and a broad range of proficiencies...
June 14, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38866699/re-association-of-metformin-use-and-cancer-incidence-a-systematic-review-and-meta-analysis
#8
JOURNAL ARTICLE
Charles Khouri, Samy Suissa
No abstract text is available yet for this article.
June 13, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38866698/re-plea-to-stop-calling-for-new-clinical-trials-to-test-metformin-in-cancer
#9
JOURNAL ARTICLE
Holli A Loomans-Kropp
No abstract text is available yet for this article.
June 13, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38867688/resource-requirements-to-accelerate-clinical-applications-of-next-generation-sequencing-and-radiomics-workshop-commentary-and-review
#10
JOURNAL ARTICLE
Lyndsay Harris, Lalitha K Shankar, Claire Hildebrandt, Wendy S Rubinstein, Kristofor Langlais, Henry Rodriguez, Adam Berger, John Freymann, Erich P Huang, P Mickey Williams, Jean Claude Zenklusen, Robert Ochs, Zivana Tezak, Berkman Sahiner
The National Institutes of Health (NIH)/U.S. Food and Drug Administration (FDA) Joint Leadership Council Next-Generation Sequencing (NGS) and Radiomics Working Group (NGS&R WG) was formed by the NIH/FDA Joint Leadership Council to promote the development and validation of innovative NGS tests, radiomic tools, and associated data analysis and interpretation enhanced by artificial intelligence (AI) and machine-learning (ML) technologies. A two-day workshop was held on September 29-30, 2021 to convene members of the scientific community to discuss how to overcome the "ground truth" gap that has frequently been acknowledged as one of the limiting factors impeding high-quality research, development, validation, and regulatory science in these fields...
June 12, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38852945/ret-overexpression-leads-to-increased-brain-metastatic-competency-in-luminal-breast-cancer
#11
JOURNAL ARTICLE
Petra Jagust, Aoibhin M Powell, Mihaela Ola, Louise Watson, Ana de Pablos-Aragoneses, Pedro García-Gómez, Ramón Fallon, Fiona Bane, Mona Heiland, Gareth Morris, Brenton Cavanagh, Jason McGrath, Daniela Ottaviani, Aisling Hegarty, Sinéad Cocchiglia, Kieron J Sweeney, Stephen MacNally, Francesca M Brett, Jane Cryan, Alan Beausang, Patrick Morris, Manuel Valiente, Arnold D K Hill, Damir Varešlija, Leonie S Young
BACKGROUND: Breast cancer brain metastasis is a rising occurrence, necessitating a better understanding of the mechanisms involved for effective management. Breast cancer brain metastases diverge notably from the primary tumor, with gains in kinase and concomitant losses of steroid signaling observed. In this study, we explored the role of the kinase receptor RET in promoting breast cancer brain metastases and provide a rationale for targeting this receptor. METHODS: RET expression was characterized in a cohort of patients with primary and brain metastatic tumors...
June 10, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38851882/re-spatial-intratumor-heterogeneity-of-programmed-death-ligand-1-expression-predicts-poor-prognosis-in-resected-non-small-cell-lung-cancer
#12
JOURNAL ARTICLE
Xuewei Wu, Bin Zhang
No abstract text is available yet for this article.
June 8, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38848476/re-spatial-intratumor-heterogeneity-of-programmed-death-ligand-1-expression-predicts-poor-prognosis-in-resected-non-small-cell-lung-cancer
#13
JOURNAL ARTICLE
Tetsuro Taki, Genichiro Ishii
No abstract text is available yet for this article.
June 7, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38845087/evaluating-a-blood-test-for-colon-cancer-screening-how-simulation-modeling-can-inform-clinical-policy-making-and-research
#14
JOURNAL ARTICLE
David F Ransohoff
No abstract text is available yet for this article.
June 6, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38845078/epidemiology-of-early-vs-late-recurrence-among-women-with-early-stage-estrogen-receptor-positive-breast-cancer-in-the-pathways-study
#15
JOURNAL ARTICLE
Alfredo V Chua, Haiyang Sheng, Emily Liang, Shipra Gandhi, Marilyn L Kwan, Isaac J Ergas, Janise M Roh, Cecile A Laurent, Li Yan, Thaer Khoury, Christine B Ambrosone, Lawrence H Kushi, Song Yao
BACKGROUND: Relatively little is known about the differences in prognostic factors for early vs late recurrence among women with early-stage estrogen receptor-positive (ER+) breast cancer. METHODS: We analyzed factors related to early (<5 years) vs late (≥5 years) recurrence in 2,992 women with stage I-IIB ER+ breast cancer in the Pathways Study, a prospective cohort of women with breast cancer enrolled between 2006 and 2013, with ascertainment of recurrence and death through December 2021...
June 6, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38845072/characteristics-of-a-cost-effective-blood-test-for-colorectal-cancer-screening
#16
JOURNAL ARTICLE
Pedro Nascimento De Lima, Rosita Van Den Puttelaar, Amy B Knudsen, Anne I Hahn, Karen M Kuntz, Jonathan Ozik, Nicholson Collier, Fernando Alarid-Escudero, Ann G Zauber, John M Inadomi, Iris Lansdorp-Vogelaar, Carolyn M Rutter
BACKGROUND: Blood-based biomarker tests can potentially change the landscape of colorectal cancer (CRC) screening. We characterize the conditions under which blood test screening would be as effective and cost-effective as annual fecal immunochemical testing (FIT) or decennial colonoscopy. METHODS: We used the three CISNET-Colon models to compare scenarios of no screening, annual FIT, decennial colonoscopy, and a blood test meeting CMS coverage criteria (74% CRC sensitivity and 90% specificity)...
June 6, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38837384/dietary-interventions-statistical-power-and-unanswered-questions
#17
JOURNAL ARTICLE
Calvin Smith, Christopher M Booth, Ghulam Rehman Mohyuddin
No abstract text is available yet for this article.
June 5, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38837335/future-patterns-in-burden-and-incidence-of-squamous-cell-carcinoma-of-the-anus-in-the-united-states-2001-2035
#18
JOURNAL ARTICLE
Ashvita Garg, Haluk Damgacioglu, Keith Sigel, Alan G Nyitray, Gary M Clifford, Thomas Curran, Gweneth Lazenby, Eric G Meissner, Katherine Sterba, Kalyani Sonawane, Ashish A Deshmukh
Squamous cell carcinoma of the anus (SCCA) incidence has been rising in the United States, particularly among older adults (≥65 years). We estimated the impact of this rise on future burden (through 2035) using age-period-cohort modeling. The SCCA burden (cases/year) is expected to rise, reaching ∼2700 among men and ∼7000 among women in 2031-2035 (burden during 2016-2020 among men and women was ∼2150 and ∼4600), with most cases aged ≥65 years (61% in men and 70% in women in 2031-2035; from 40% and 46% in 2016-2020)...
June 5, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38833681/different-dosage-forms-of-gnrha-with-endocrine-therapy-in-premenopausal-hormone-receptor-positive-breast-cancer
#19
JOURNAL ARTICLE
Jinna Lin, Yiye Ouyang, Yudong Li, Liang Jin, Shunying Li, Yujie Liu, Yaping Yang, Qianfeng Shi, Mengdi Zhu, Zijie Cai, Jingru Wang, Nianqiu Liu, Yue Hu, Zongqi Wu, Mengzi Wu, Lok Lam Wong, Xiaoting Jiang, Qi Wang, Wang Yang, Qiang Liu
BACKGROUND: Despite the wide use of a three-month gonadotropin-releasing hormone agonist (3M GnRHa) for ovarian function suppression (OFS) in premenopausal breast cancer patients, it remains unclear whether it is as effective and safe as a one-month GnRHa regimen (1M GnRHa) when combined with selective estrogen receptor modulators (SERMs) or aromatase inhibitors (AIs), especially in younger patients. METHODS: This retrospective cohort study included 1109 premenopausal hormone receptor-positive (HR+) breast cancer patients treated with GnRHa plus SERM or AI...
June 4, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38833676/batf-dependent-th17-cells-act-through-il23r-pathway-to-promote-prostate-adenocarcinoma-initiation-and-progression
#20
JOURNAL ARTICLE
Sen Liu, Seleste L Rivero, Bing Zhang, Keyi Shen, Zixuan Li, Tianhua Niu, Brian G Rowan, S Michal Jazwinski, Asim B Abdel Mageed, Chad Steele, Alun R Wang, Oliver Sartor, Qiuyang Zhang
BACKGROUND: The role of Th17 cells in prostate cancer (PCa) is not fully understood. The transcription factor BATF controls the differentiation of Th17 cells. Mice deficient in Batf do not produce Th17 cells. METHODS: In this study, we aimed to characterize the role of Batf-dependent Th17 cells in PCa by crossbreeding Batf knockout (Batf-/-) mice with mice conditionally mutant for Pten. We found that Batf-/- mice had changes in the morphology of prostate epithelial cells compared to normal mice, and Batf-/- mice deficient in Pten (named Batf-) had smaller prostate size and developed fewer invasive prostate adenocarcinomas than Pten-deficient mice with Batf expression (named Batf+)...
June 4, 2024: Journal of the National Cancer Institute
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