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JOURNAL ARTICLE
Melyssa Aronson, Robert Gryfe, Yun-Hee Choi, Kara Semotiuk, Spring Holter, Thomas Ward, Steve Gallinger, Zane Cohen, Laurent Briollais
BACKGROUND: Lynch Syndrome (LS) screening guidelines originally recommended colonoscopy every 1 to 2 years, beginning between the ages of 20-25 years. Recent studies have questioned the benefits of these short screening intervals in preventing colorectal cancer (CRC). Our goal is to determine how colonoscopy screening intervals impact CRC in patients with LS. METHODS: We analyzed the demographics, screening practices and outcomes of patients with LS identified through the clinic based Familial Gastrointestinal Cancer Registry at the Zane Cohen Centre, Sinai Health System, Toronto...
March 25, 2023: Journal of the National Cancer Institute
#2
JOURNAL ARTICLE
Bailey A Martin-Giacalone, Melissa A Richard, Michael E Scheurer, Javed Khan, Pagna Sok, Priya B Shetty, Stephen J Chanock, Shengchao Alfred Li, Meredith Yeager, Deborah A Marquez-Do, Donald A Barkauskas, David Hall, Matthew T McEvoy, Austin L Brown, Aniko Sabo, Paul Scheet, Chad D Huff, Stephen X Skapek, Douglas S Hawkins, Rajkumar Venkatramani, Lisa Mirabello, Philip J Lupo
BACKGROUND: Relative to other pediatric cancers, survival for rhabdomyosarcoma has not improved in recent decades, suggesting the need to enhance risk stratification. Therefore, we conducted a genome-wide association study for event-free survival (EFS) and overall survival (OS) to identify genetic variants associated with outcomes in individuals with rhabdomyosarcoma. METHODS: The study included 920 individuals with newly diagnosed rhabdomyosarcoma who were enrolled on Children's Oncology Group protocols...
March 23, 2023: Journal of the National Cancer Institute
#3
JOURNAL ARTICLE
Joseph M Unger, Cathee Till, Jessica P Hwang, Kathryn B Arnold, Michael Leblanc, Dawn L Hershman, Scott D Ramsey
BACKGROUND: Screening for viral infection in cancer patients is inconsistent. A mechanism to readily identify cancer patients at increased risk of existing or prior viral infection could enhance screening efforts while reducing costs. METHODS: We identified factors associated with increased risk of past or chronic HBV, HCV, or HIV infection prior to initiation of systemic cancer therapy. Data were from a multicenter prospective cohort study of 3,051 patients with newly diagnosed cancer (SWOG-S1204) enrolled between 2013-2017...
March 22, 2023: Journal of the National Cancer Institute
#4
JOURNAL ARTICLE
Shan Song
No abstract text is available yet for this article.
March 22, 2023: Journal of the National Cancer Institute
#5
JOURNAL ARTICLE
Elad Sharon, Jared C Foster
We consider the design of phase II trials evaluating combinations of experimental therapies. In the modern era, many immunotherapy and targeted therapy regimens are being developed as combination regimens, including combinations consisting only of experimental agents. In some clinical/drug development scenarios, it may be difficult to isolate the effect of the individual agents making up a combination of this type, which makes the evaluation of the combination challenging. One such scenario arises when none of the agents making up the experimental combination have demonstrated single-agent activity in the clinical setting of interest...
March 21, 2023: Journal of the National Cancer Institute
#6
JOURNAL ARTICLE
Sara Lindström, Lu Wang, Helian Feng, Arunabha Majumdar, Sijia Huo, James Macdonald, Tabitha Harrison, Constance Turman, Hongjie Chen, Nicholas Mancuso, Theo Bammler, Steve Gallinger, Stephen B Gruber, Marc J Gunter, Loic Le Marchand, Victor Moreno, Kenneth Offit, Immaculata de Vivo, Tracy A O'Mara, Amanda B Spurdle, Ian Tomlinson, Rebecca Fitzgerald, Puya Gharahkhani, Ines Gockel, Janusz Jankowski, Stuart Macgregor, Johannes Schumacher, Jill Barnholtz-Sloan, Melissa L Bondy, Richard S Houlston, Robert B Jenkins, Beatrice Melin, Margaret Wrensch, Paul Brennan, David Christiani, Mattias Johansson, James Mckay, Melinda C Aldrich, Christopher I Amos, Maria Teresa Landi, Adonina Tardon, D Timothy Bishop, Florence Demenais, Alisa M Goldstein, Mark M Iles, Peter A Kanetsky, Matthew H Law, Laufey T Amundadottir, Rachael Stolzenberg-Solomon, Brian M Wolpin, Alison Klein, Gloria Petersen, Harvey Risch, Stephen J Chanock, Mark P Purdue, Ghislaine Scelo, Paul Pharoah, Siddhartha Kar, Rayjean J Hung, Bogdan Pasaniuc, Peter Kraft
BACKGROUND: The shared inherited genetic contribution to risk of different cancers is not fully known. In this study, we leverage results from twelve cancer genome-wide association studies (GWAS) to quantify pair-wise genome-wide genetic correlations across cancers and identify novel cancer susceptibility loci. METHODS: We collected GWAS summary statistics for twelve solid cancers based on 376,759 cancer cases and 532,864 controls of European ancestry. The included cancer types were breast, colorectal, endometrial, esophageal, glioma, head and neck, lung, melanoma, ovarian, pancreatic, prostate, and renal cancers...
March 17, 2023: Journal of the National Cancer Institute
#7
JOURNAL ARTICLE
Jorge S Reis-Filho, Jakob Nikolas Kather
Pathologists worldwide are facing remarkable challenges with the increasing workloads and the lack of time to provide consistently high-quality patient care. The application of artificial intelligence (AI) to digital whole slide images has the potential of democratizing the access to expert pathology and affordable biomarkers, by supporting pathologists in the provision of timely and accurate diagnosis as well as supporting oncologists by extracting prognostic and predictive biomarkers directly from tissue slides...
March 17, 2023: Journal of the National Cancer Institute
#8
JOURNAL ARTICLE
R Donald Harvey
No abstract text is available yet for this article.
March 15, 2023: Journal of the National Cancer Institute
#9
JOURNAL ARTICLE
Andrea C Betts, L Aubree Shay, Philip J Lupo, Sandi L Pruitt, Michael E Roth, Marlyn A Allicock, Barbara A Cohn, Caitlin C Murphy
BACKGROUND: We examined adverse birth outcomes among adolescent and young adult women diagnosed with cancer (AYA women, ages 15-39 years) during pregnancy. METHODS: We linked data from the Texas Cancer Registry, vital records, and Texas Birth Defects Registry to identify all singleton births to AYA women diagnosed during pregnancy from January 1999 to December 2016. We compared prevalence of adverse live birth outcomes between AYA women and women without cancer (matched 1:4 on age, race and ethnicity, and year)...
March 13, 2023: Journal of the National Cancer Institute
#10
JOURNAL ARTICLE
Ya-Chen Tina Shih, Cathy Bradley, K Robin Yabroff
No abstract text is available yet for this article.
March 13, 2023: Journal of the National Cancer Institute
#11
(no author information available yet)
No abstract text is available yet for this article.
March 6, 2023: Journal of the National Cancer Institute
#12
JOURNAL ARTICLE
Kyeong Jin Kim, Kyoung Jin Kim, Jimi Choi, Nam Hoon Kim, Sin Gon Kim
BACKGROUND: We aimed to investigate whether the risk of second primary malignancy (SPM) in TC patients receiving RAI therapy increases in a cumulative dose-dependent manner compared to those without. METHODS: Using the Korean National Health Insurance Service-National Health Information Database (NHIS-NHID, 2002-2019), we investigated hazard ratios (HRs) of SPM associated with RAI in TC. SPM was defined as a second primary malignancy diagnosed at least 1 year after TC diagnosis...
February 23, 2023: Journal of the National Cancer Institute
#13
JOURNAL ARTICLE
Gloria D Coronado, Renée M Ferrari, Autumn Barnes, Sheila F Castañeda, Mark Cromo, Melinda M Davis, Mark Doescher, Kevin English, Jenna Hatcher, Karen E Kim, Sarah Kobrin, David Liebovitz, Shiraz I Mishra, Jesse N Nodora, Wynne E Norton, Jill M Oliveri, Daniel S Reuland, Sujha Subramanian, Jamie H Thompson, Electra D Paskett
BACKGROUND: Although patient navigation has shown promise for increasing participation in colorectal cancer (CRC) screening and follow-up, little evidence is available to guide implementation of patient navigation in clinical practice. We characterize eight patient navigation programs being implemented as part of multi-component interventions of the National Cancer Institute's Cancer MoonshotSM Accelerating Colorectal Cancer Screening and Follow-Up Through Implementation Science (ACCSIS) initiative...
February 22, 2023: Journal of the National Cancer Institute
#14
JOURNAL ARTICLE
Agnès Fournier, Manon Cairat, Gianluca Severi, Marc J Gunter, Sabina Rinaldi, Laure Dossus
BACKGROUND: Epidemiological studies have found that menopausal hormone therapy (MHT) use is associated with an increased ovarian cancer risk. However, whether different MHT types confer the same level of risk is unclear. We estimated the associations between different MHT types and the risk of ovarian cancer in a prospective cohort. METHODS: The study population included 75,606 postmenopausal women from the E3N cohort. Exposure to MHT was identified from self-reports in biennial questionnaires between 1992 and 2004 and from drug claim data matched to the cohort between 2004 and 2014...
February 21, 2023: Journal of the National Cancer Institute
#15
JOURNAL ARTICLE
Mikkel Bandak, Kristine Skovly Nielsen, Michael Kreiberg, Thomas Wagner, Josephine Rosenvilde, Charlotta Pissinger, Christoffer Johansen, Gedske Daugaard, Jakob Lauritsen
We investigated the impact of smoking on overall survival (OS) in testicular germ cell cancer (TC) patients receiving first line combination chemotherapy (BEP). Patients who received BEP for metastatic TC were identified in the Danish Testicular Cancer (DaTeCa) database. Information on smoking status at the time of diagnosis was obtained by medical record review. OS and cause of death was compared between current smokers and never-smokers Of 1,883 eligible patients, information on smoking status was available in 1,156 patients, of whom 602 were current smokers...
February 20, 2023: Journal of the National Cancer Institute
#16
JOURNAL ARTICLE
Sharonda M Lovett, Dale P Sandler, Katie M O'Brien
BACKGROUND: Gynecologic surgery is hypothesized to reduce risk of breast cancer; however, associations may be modified by subsequent hormone use. Our objective was to examine the association between gynecologic surgery and breast cancer incidence considering the use of hormone therapy. METHODS: The Sister Study is a prospective cohort of initially breast cancer-free women aged 35-74 years with a sister who had breast cancer. We used Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between gynecologic surgery (no surgery, hysterectomy only, bilateral oophorectomy with or without hysterectomy) and incident breast cancer among 50,701 women...
February 20, 2023: Journal of the National Cancer Institute
#17
JOURNAL ARTICLE
Heather S L Jim, Renee Brady-Nicholls, Dawn L Hershman
No abstract text is available yet for this article.
February 20, 2023: Journal of the National Cancer Institute
#18
(no author information available yet)
No abstract text is available yet for this article.
February 16, 2023: Journal of the National Cancer Institute
#19
JOURNAL ARTICLE
Mariana Chavez-MacGregor, Xiudong Lei, Catalina Malinowski, Hui Zhao, Ya-Chen Shih, Sharon H Giordano
BACKGROUND: Medicaid expansion under the Affordable Care Act extends eligibility for participating states has been associated with improved outcomes by facilitating access to care. Delayed initiation of adjuvant chemotherapy is associated with worse outcomes among patients with early-stage breast cancer (BC). The impact of Medicaid expansion in narrowing delays by race and ethnicity has not been studied. METHODS: Population-based study using the National Cancer Database...
February 16, 2023: Journal of the National Cancer Institute
#20
JOURNAL ARTICLE
Jean C Bikomeye, Yuhong Zhou, Emily L McGinley, Bethany Canales, Tina W F Yen, Sergey Tarima, Sara Beltrán Ponce, Kirsten M M Beyer
BACKGROUND: Breast cancer (BC) is the most common cancer among US women; and institutional racism is a critical cause of health disparities. We investigated impacts of historical redlining on BC treatment receipt and survival in the US. METHODS: Home Owners' Loan Corporation (HOLC) boundaries were used to measure historical redlining. Eligible women in the 2010-2017 SEER-Medicare BC Cohort were assigned an HOLC grade. The independent variable was a dichotomized HOLC grade: A/B (non-redlined), and C/D (redlined)...
February 16, 2023: Journal of the National Cancer Institute
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