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JOURNAL ARTICLE
Noah Charles Peeri, Kimberly A Bertrand, Renhua Na, Immaculata De Vivo, Veronica Wendy Setiawan, Venkatraman E Seshan, Laia Alemany, Yu Chen, Megan A Clarke, Tess Clendenen, Linda S Cook, Laura Costas, Luigino Dal Maso, Jo L Freudenheim, Christine M Friedenreich, Gretchen L Gierach, Marc T Goodman, Carlo La Vecchia, Fabio Levi, Marta Lopez-Querol, Lingeng Lu, Kirsten B Moysich, George Mutter, Jeffin Naduparambil, Eva Negri, Kelli O'Connell, Tracy O'Mara, Julie R Palmer, Fabio Parazzini, Kathryn Lee Penney, Stacey Petruzella, Peggy Reynolds, Fulvio Ricceri, Harvey Risch, Thomas E Rohan, Carlotta Sacerdote, Sven Sandin, Xiao-Ou Shu, Rachael Z Stolzenberg-Solomon, Penelope M Webb, Nicolas Wentzensen, Lynne R Wilkens, Wanghong Xu, Herbert Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Xingyi Guo, Loren Lipworth, Mengmeng Du
BACKGROUND: The American Cancer Society recommends physicians inform average risk women about endometrial cancer (EC) risk on reaching menopause, but new diagnoses are rising fastest in women <50 years. Educating these women about EC risks requires knowledge of risk factors. However, EC in young women is rare and challenging to study in single study populations. METHODS: We included 13,846 incident EC patients (1,639 < 50 years) and 30,569 matched control individuals from the Epidemiology of Endometrial Cancer Consortium...
September 5, 2024: Journal of the National Cancer Institute
#2
JOURNAL ARTICLE
Katrina A B Goddard, Eric J Feuer, Asad Umar, Philip E Castle
Improvements in cancer prevention and control are poised to be main contributors in reducing the burden of cancer in the US. We quantify top opportunities to accelerate progress using projected life years gained (LYG) and deaths averted as measures. We project that over the next 25 years, realistic gains from tobacco control can contribute 0.4 to 17 million additional LYG per intervention and 8.4 million additional LYG from improving uptake of screening programs over the lifetime of 25 annual cohorts...
September 3, 2024: Journal of the National Cancer Institute
#3
JOURNAL ARTICLE
Christina S Boutros, Hanna Kakish, Omkar S Pawar, Alexander W Loftus, John B Ammori, Jeremy Bordeaux, Ankit Mangla, Iris Sheng, Gary Schwartz, Luke D Rothermel, Richard S Hoehn
INTRODUCTION: The NCCN considers "baseline staging" (whole body CT or PET scan +/- brain MRI) for all asymptomatic melanoma patients with a positive sentinel lymph node biopsy. The true yield of these workups is unknown. METHODS: We created cohorts of adult malignant melanoma patients, using the National Cancer Database (2012-2020) to mimic three common scenarios: (1) clinically node negative, with positive sentinel lymph node(s) (SLNB[+]); (2) clinically node negative, with negative sentinel lymph node(s) (SLNB[-]); (3) clinically node positive with confirmed lymph node metastases (cN[+] and pN[+])...
September 2, 2024: Journal of the National Cancer Institute
#4
JOURNAL ARTICLE
Vanita Noronha, Vijay Maruti Patil, Nandini Menon, Amit Joshi, Minit Jalan Shah, Ajaykumar Singh, Supriya Goud, Srushti Shah, Sucheta More, Kavita Nawale, Dipti Nakti, Akanksha Yadav, Shweta Jogdhankar, Rajeev Kumar, Virendra Kumar Tiwari, Devayani Niyogi, Nilendu Purandare, Amit Janu, Nivedita Chakrabarty, Abhishek Mahajan, Anil Tibdewal, Jaiprakash Agarwal, Akash Pawar, Oindrila Roy Chowdhury, Vibhor Sharma, Venkatesh Kapu, Mehak Trika, Srigadha Vivek Kumar, Manali Kolkur, Priyanka Bhagyavant, Zoya Peelay, Rutvij Khedkar, Medha Jain, Rajendra Badwe, Kumar Prabhash
PURPOSE: Standard neoadjuvant chemotherapy (NACT) for locally advanced esophageal/gastroesophageal junction squamous cancer (LAEGSC), 5-fluorouracil (5FU)+platinum, is toxic and logistically challenging; alternative regimens are needed. PATIENTS AND METHODS: Phase III randomized open-label non-inferiority trial at Tata Memorial Center, India, in resectable LAEGSC. Patients were randomized 1:1 to three cycles of 3-weekly platinum (cisplatin 75 mg/m2 or carboplatin AUC 6) with paclitaxel 175 mg/m2 (day 1) or 5FU 1000 mg/m2 continuous infusion (days 1-4), followed by surgery...
September 2, 2024: Journal of the National Cancer Institute
#5
(no author information available yet)
No abstract text is available yet for this article.
August 30, 2024: Journal of the National Cancer Institute
#6
JOURNAL ARTICLE
En Cheng, Fang-Shu Ou, Clare Gatten, Chao Ma, Alan P Venook, Heinz-Josef Lenz, Eileen M O'Reilly, Peter T Campbell, Chaoyuan Kuang, Bette J Caan, Charles D Blanke, Kimmie Ng, Jeffrey A Meyerhardt
BACKGROUND: Plant-based diet is associated with better survival among patients with non-metastatic colorectal cancer (CRC), but its association in metastatic CRC is unknown. METHODS: Using an NCI-sponsored trial (CALGB/SWOG 80405), we included 1,284 patients who completed validated food frequency questionnaires at the initiation of metastatic CRC treatment. We calculated three indices: overall plant-based diet index (PDI), which emphasized consumption of all plant foods while reducing animal food intake; healthful plant-based diet index (hPDI), which emphasized consumption of healthful plant foods such as whole grains, fruits, and vegetables; and unhealthful plant-based diet index (uPDI), which emphasized consumption of less healthful plant foods such as fruit juices, refined grains, and sugar-sweetened beverages...
August 30, 2024: Journal of the National Cancer Institute
#7
JOURNAL ARTICLE
Lauren M Janczewski, Michael R Visenio, Rachel Hae-Soo Joung, Anthony D Yang, David D O'Dell, Elizabeth C Danielson, Mitchell C Posner, Ted A Skolarus, David J Bentrem, Karl Y Bilimoria, Ryan P Merkow
BACKGROUND: Pancreatic cancer remains highly lethal and resection represents the only chance for cure. Although patients are counseled regarding short-term (0-3 months) mortality, little is known about mortality 3-6 months (intermediate-term) following surgery. We assessed predictors of intermediate-term mortality, evaluated hospital-level variation, and developed a nomogram to predict intermediate-term mortality risk. METHODS: Patients undergoing pancreatic cancer resection were identified from the National Cancer Database (2010-2020)...
August 30, 2024: Journal of the National Cancer Institute
#8
JOURNAL ARTICLE
Jeanne S Mandelblatt, Michael H Antoni, Traci N Bethea, Steve Cole, Barry I Hudson, Frank J Penedo, Amelie G Ramirez, G William Rebeck, Swarnavo Sarkar, Ann G Schwartz, Erica K Sloan, Yun-Ling Zheng, Judith E Carroll, Mina S Sedrak
The central premise of this article is that a portion of the established relationships between social determinants of health and racial/ethnic disparities in cancer morbidity and mortality are mediated through differences in rates of biological aging processes. We further posit that using knowledge about aging could enable discovery and testing of new mechanism-based pharmaceutical and behavioral interventions ("gerotherapeutics") to differentially improve the health of minoritized cancer survivors and reduce cancer disparities...
August 28, 2024: Journal of the National Cancer Institute
#9
JOURNAL ARTICLE
Debodipta Das, Xiaojing Wang, Yu-Chiao Chiu, Hakim Bouamar, Francis E Sharkey, Jorge E Lopera, Zhao Lai, Susan T Weintraub, Xianlin Han, Yi Zou, Hung-I H Chen, Carla R Zeballos Torrez, Xiang Gu, Matyas Cserhati, Joel E Michalek, Glenn A Halff, Yidong Chen, Siyuan Zheng, Francisco G Cigarroa, Lu-Zhe Sun
BACKGROUND: The incidence and mortality rates of hepatocellular carcinoma (HCC) among Hispanic individuals in the United States are much higher than in non-Hispanic white people. We conducted multi-omics analyses to elucidate molecular alterations in HCC among Hispanic patients. METHODS: Paired tumor and adjacent non-tumor samples were collected from 31 Hispanic HCCs in South Texas (STX-Hispanic) for genomic, transcriptomic, proteomic, and metabolomic profiling...
August 27, 2024: Journal of the National Cancer Institute
#10
JOURNAL ARTICLE
Yin Zhang, Sara Lindström, Peter Kraft, Yuxi Liu
BACKGROUND: Early-onset cancer (diagnosed under age 50) generally manifests as an aggressive disease phenotype. The association between healthy lifestyle and early-onset cancer and whether it varies by common genetic variants remains unclear. METHODS: We analyzed a prospective cohort of 66,308 participants who were under age 50 and free of cancer at baseline in the UK Biobank. Using Cox regression, we estimated Hazard ratios (HRs) and 95% confidence intervals (CIs) for early-onset total and breast cancer based on sex-specific composite total cancer polygenic risk scores (PRSs), a breast cancer-specific PRS, and sex-specific health-associated lifestyle scores (HLSs)...
August 27, 2024: Journal of the National Cancer Institute
#11
JOURNAL ARTICLE
Justin C Brown, Chao Ma, Qian Shi, Felix Couture, Philip Kuebler, Pankaj Kumar, Benjamin Tan, Smitha Krishnamurthi, Victor Chang, Richard M Goldberg, Eileen M O'Reilly, Anthony F Shields, Jeffrey A Meyerhardt
BACKGROUND: Both inflammation and insufficient physical inactivity contribute to individual-level risk of disease recurrence and death in stage III colon cancer. The extent to which increased inflammatory risk can be offset by sufficient physical activity remains unknown. METHODS: This cohort study was nested within the CALGB/SWOG 80702 (Alliance) randomized trial. Inflammatory burden was quantified by high-sensitivity C-reactive protein, interleukin-6, and soluble tumor necrosis factor-α receptor 2 after recovery from tumor resection...
August 24, 2024: Journal of the National Cancer Institute
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JOURNAL ARTICLE
Jason Domogauer, Marina Stasenko, Gwendolyn P Quinn, Matthew B Schabath
No abstract text is available yet for this article.
August 24, 2024: Journal of the National Cancer Institute
#13
JOURNAL ARTICLE
Giovanna Tosato, Yuyi Wang
No abstract text is available yet for this article.
August 23, 2024: Journal of the National Cancer Institute
#14
EDITORIAL
William D Foulkes, Paz Polak
No abstract text is available yet for this article.
August 22, 2024: Journal of the National Cancer Institute
#15
EDITORIAL
Gary M Clifford
No abstract text is available yet for this article.
August 22, 2024: Journal of the National Cancer Institute
#16
JOURNAL ARTICLE
Qinran Liu, Heidy N Medina, Tulay Koru-Sengul, Estelamari Rodriguez, Gilberto Lopes, Frank J Penedo, Farhad Islami, Paulo S Pinheiro
BACKGROUND: Despite the importance of early detection for lung cancer outcomes, staging disparities among the growing US Hispanic population remain underexplored. This population-based study aimed to identify racial-ethnic disparities among non-Hispanic White, non-Hispanic Black, and Hispanic (including specific subgroups) patients in stage at diagnosis for potentially curable non-small cell lung cancer (NSCLC). METHODS: Incident NSCLC cases (2005-2018) were extracted from the Florida cancer registry...
August 21, 2024: Journal of the National Cancer Institute
#17
JOURNAL ARTICLE
Alexander Troester, Romil Parikh, Bronwyn Southwell, Elizabeth Ester, Shahnaz Sultan, Edward Greeno, Elliot Arsoniadis, Timothy R Church, Timothy Wilt, Mary Butler, Paolo Goffredo
PURPOSE: To assess the effectiveness and harms of initial treatment strategies for stages I-III anal squamous cell cancer (SCC). METHODS: We searched Medline®, Embase®, and CENTRAL®, between January 1, 2000- March 2024, for randomized controlled trials and nonrandomized studies of interventions comparing initial treatment strategies. Individual study risk of bias (RoB) and overall strength of evidence (SOE) were evaluated for a prespecified outcome list using standardized methods...
August 20, 2024: Journal of the National Cancer Institute
#18
JOURNAL ARTICLE
Melanie R Somekh, Jason M Ashford, Michelle A Swain, Lana L Harder, Bonnie L Carlson-Green, Joanna Wallace, Ryan J Kaner, Catherine A Billups, Arzu Onar-Thomas, Jeanelle S Ali, Jennifer L Harman, Thomas E Merchant, Amar Gajjar, Heather M Conklin
BACKGROUND: Young children treated for central nervous system (CNS) malignancies are at high risk for difficulties with academic functioning due to increased vulnerability of the developing brain and missed early developmental opportunities. Extant literature examining academics in this population is limited. We investigated academic readiness, its clinical and demographic predictors, and its relationship with distal academic outcomes among patients treated for CNS tumors during early childhood...
August 20, 2024: Journal of the National Cancer Institute
#19
JOURNAL ARTICLE
Yujia Lu, Yu Chen Zhao, Kuangyu Liu, Alaina Bever, Ziyi Zhou, Kai Wang, Zhe Fang, Georgios Polychronidis, Yuchen Liu, Liyuan Tao, Barbra A Dickerman, Edward L Giovannucci, Mingyang Song
BACKGROUND: Despite the recognized role of visceral adipose tissue (VAT) in carcinogenesis, its independent association with cancer risk beyond traditional obesity measures remains unknown due to limited availability of imaging data. METHODS: We developed an estimation equation for VAT volume (L) using Elastic Net Regression based on demographic and anthropometric data in a subcohort of participants in the UK Biobank (UKB; N = 23,148) with abdominal MRI scans...
August 16, 2024: Journal of the National Cancer Institute
#20
JOURNAL ARTICLE
Sergi Trias-Llimós, Elisenda Rentería, Roberta Rutigliano, Ajay Aggarwal, Jennifer Moodley, Karla Unger-Saldaña, Isabelle Soerjomataram
BACKGROUND: Females live longer than males, which results in a sex gap in life expectancy. This study examines the contribution of female cancers to this differential by world region and country 1990-2019 with special focus to the 15-69 age group. METHODS: Cause-specific mortality data for 30 cancers, including four female-specific cancers from 238 countries and territories was retrieved from the Global Burden of Disease Study 2019. Using life table techniques and demographic decomposition analysis, we estimated the contribution of cancer deaths to the sex gap in life expectancy by age and calendar period...
August 14, 2024: Journal of the National Cancer Institute
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