journal
https://read.qxmd.com/read/38801652/ebola-virus-specific-neutralizing-antibody-persists-at-high-levels-in-survivors-2-years-after-resolution-of-disease-in-a-sierra-leonean-cohort
#41
JOURNAL ARTICLE
Nell G Bond, Kayla R Shore, Emily J Engel, Erin E Coonan, Foday Al-Hasan, Michael A Gbakie, Fatima K Kamara, Lansana Kanneh, Mambu Momoh, Ibrahim M Kanneh, John D Sandi, Debra Elliott, Samuel C Ficenec, Ashley R Smira, William A Fischer, David A Wohl, James E Robinson, Jeffrey G Shaffer, Robert F Garry, Robert J Samuels, Donald S Grant, John S Schieffelin
Ebola virus (EBOV) infection results in Ebola virus disease (EVD), an often severe disease with a nonspecific presentation. Since its recognition, periodic outbreaks of EVD continue to occur in sub-Saharan Africa. The 2013-2016 West African EVD outbreak was the largest recorded, resulting in a substantial cohort of EVD survivors with persistent health complaints and variable immune responses. In this study, we characterize humoral immune responses in EVD survivors and their contacts in Eastern Sierra Leone...
May 27, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38798080/whispers-in-the-wind-face-mask-sampling-for-mycobacterium-tuberculosis-detection-in-children-with-pulmonary-tuberculosis
#42
JOURNAL ARTICLE
Lennard Meiwes, Irina Kontsevaya, Dumitru Chesov, Stela Kulciţkaia, Viola Dreyer, Doris Hillemann, Qiniso Dlamini, Caroline Williams, Michael Barer, Folke Brinkmann, Renate Krüger, Stephanie Thee, Alexander Kay, Anna Maria Mandalakas, Christoph Lange
BACKGROUND: Recently, face mask sampling (FMS) confirmed detection of Mycobacterium tuberculosis DNA from exhaled breath in adults with TB. To date, no study has evaluated the use of FMS to detect pulmonary Tuberculosis (TB) in children. We developed a method for FMS of M. tuberculosis-specific DNA in children and performed a clinical exploration to assess feasibility in children. METHODS: Face masks were spiked, analysed on GeneXpert-Ultra, qPCR, and tNGS. Children with pulmonary TB were asked to wear three modified FFP2 masks for 30 minutes as part of an exploratory clinical study...
May 27, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38794931/characterizing-the-etiology-of-recurrent-tuberculosis-using-whole-genome-sequencing-alaska-usa-2008-2020
#43
JOURNAL ARTICLE
Yuri P Springer, Megan L Tompkins, Katherine Newell, Martin Jones, Scott Burns, Bruce Chandler, Lauren S Cowan, J Steve Kammerer, James E Posey, Kala M Raz, Michelle Rothoff, Benjamin J Silk, Yvette L Vergnetti, Joseph B McLaughlin, Sarah Talarico
BACKGROUND: Understanding the etiology of recurrent tuberculosis (rTB) is important for effective TB control. Prior to the advent of whole genome sequencing (WGS), attributing rTB to relapse or reinfection using genetic information was complicated by the limited resolution of conventional genotyping methods. METHODS: We applied a systematic method of evaluating whole genome single nucleotide polymorphism (wgSNP) distances and results of phylogenetic analyses to characterize the etiology of rTB in American Indian and Alaska Native (AIAN) persons in Alaska during 2008-2020...
May 24, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38781449/fecal-microbiota-and-volatile-metabolome-pattern-alterations-precede-late-onset-meningitis-in-preterm-neonates
#44
JOURNAL ARTICLE
Nina M Frerichs, Nancy Deianova, Sofia El Manouni El Hassani, Animesh Acharjee, Mohammed Nabil Quraishi, Willem P de Boode, Veerle Cossey, Christian V Hulzebos, Anton H van Kaam, Boris W Kramer, Esther d'Haens, Wouter J de Jonge, Daniel C Vijlbrief, Mirjam M van Weissenbruch, Emma Daulton, Alfian N Wicaksono, James A Covington, Marc A Benninga, Nanne K H de Boer, Johannes B van Goudoever, Hendrik J Niemarkt, Tim G J de Meij
OBJECTIVE: The fecal microbiota and metabolome are hypothesized to be altered before late-onset neonatal meningitis (LOM), in analogy to late-onset sepsis (LOS). The present study aimed to identify fecal microbiota composition and volatile metabolomics preceding LOM. METHODS: Cases and gestational age-matched controls were selected from a prospective, longitudinal preterm cohort study (born <30 weeks' gestation) at nine neonatal intensive care units. The microbial composition (16S rRNA sequencing) and volatile metabolome (gas chromatography-ion mobility spectrometry (GC-IMS) and GC-time-of-flight-mass spectrometry (GC-TOF-MS)), were analyzed in fecal samples 1-10 days pre-LOM...
May 23, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38781438/micro-heterogeneity-of-transmission-shapes-submicroscopic-malaria-carriage-in-coastal-tanzania
#45
JOURNAL ARTICLE
Tyler Rapp, Kano Amagai, Cyrus Sinai, Christopher Basham, Mwajabu Loya, Sifa Ngasala, Hamza Said, Meredith S Muller, Srijana B Chhetri, Guozheng Yang, Ruthly François, Melic Odas, Derrick Mathias, Jonathan J Juliano, Feng-Chang Lin, Billy Ngasala, Jessica T Lin
BACKGROUND: Asymptomatic carriage of malaria parasites persists even as malaria transmission declines. Low density infections are often submicroscopic, not detected by rapid diagnostic tests (RDTs) or microscopy, but detectable by PCR. METHODS: To characterize submicroscopic Plasmodium falciparum carriage in an area of declining malaria transmission, asymptomatic persons >5 years of age in rural Bagamoyo District, Tanzania, were screened using RDT, microscopy, and PCR...
May 23, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38779916/hepatitis-b-virus-dna-and-rna-persist-in-liver-after-serologic-recovery-in-persons-with-hepatitis-c-virus
#46
JOURNAL ARTICLE
Tanner Grudda, David L Thomas, Gregory D Kirk, Shruti H Mehta, Jacquie Astemborski, Georg M Lauer, Ashwin Balagopal, Chloe L Thio
After recovery from a hepatitis B virus (HBV) infection, reactivation can occur with immunosuppression; thus, it is assumed that replication competent HBV persists in the liver. We sought to detect persistent HBV from 13 people with spontaneous recovery. We quantified HBV DNA and RNA in core liver biopsies (median 1.72x106 cells) from people who inject drugs (PWID). Among 13 biopsies, 8 (61%) had evidence of HBV DNA or RNA and 5 (38%) had both HBV DNA and RNA. mRNAs derived from cccDNA and integrated HBV DNA...
May 23, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38779890/oops-the-microbes-did-it-again-gut-dysbiosis-precedes-late-onset-meningitis
#47
JOURNAL ARTICLE
Samantha A Whiteside, Audrey R Odom John
No abstract text is available yet for this article.
May 23, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38779889/the-clinical-effectiveness-of-fidaxomicin-compared-to-vancomycin-in-the-treatment-of-clostridioides-difficile-infection-a-single-center-real-world-experience
#48
JOURNAL ARTICLE
Majd Alsoubani, Jennifer K Chow, Angie Mae Rodday, Laura A McDermott, Seth T Walk, David M Kent, David R Snydman
BACKGROUND: The use of fidaxomicin is recommended as first line therapy for all patients with Clostridioides difficile infection (CDI). However, real-world studies have shown conflicting evidence of superiority. METHODS: We conducted a retrospective single center study of patients diagnosed with CDI between 2011-2021. A primary composite outcome of clinical failure, 30-day relapse or CDI-related death was used. A multivariable cause specific Cox proportional hazards model was used to evaluate fidaxomicin compared to vancomycin in preventing the composite outcome...
May 23, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38775628/testing-and-treatment-interventions-in-community-settings-key-to-controlling-a-recent-human-immunodeficiency-virus-outbreak-among-people-who-inject-drugs-in-glasgow-a-modeling-study
#49
JOURNAL ARTICLE
Lara I Allen, Hannah Fraser, Jack Stone, Andrew McAuley, Kirsten M A Trayner, Rebecca Metcalfe, S Erica Peters, Sharon J Hutchinson, Peter Vickerman, Matthew Hickman
BACKGROUND: A human immunodeficiency virus (HIV) outbreak was identified among people who inject drugs (PWID) in Glasgow in 2015, with >150 diagnoses by the end of 2019. The outbreak response involved scaling up HIV testing and improving HIV treatment initiation and retention. METHODS: We parameterized and calibrated a dynamic, deterministic model of HIV transmission among PWID in Glasgow to epidemiological data. We use this model to evaluate HIV testing and treatment interventions...
May 22, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38775096/comment-on-a-call-to-action-urgently-strengthening-the-future-physician-scientist-workforce-in-infectious-diseases
#50
JOURNAL ARTICLE
Aldo Barajas-Ochoa
No abstract text is available yet for this article.
May 22, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38775090/the-imperative-to-integrate-international-medical-graduates-into-the-id-physician-scientist-pathway-expanding-opportunities-and-overcoming-barriers
#51
JOURNAL ARTICLE
Talia H Swartz, Senu Apewokin, Stephen M Carpenter, Rana Chakraborty, Ann M Dennis, Eric Houpt, Neeraj K Surana, Danielle M Zerr, Liise-Anne Pirofski
No abstract text is available yet for this article.
May 22, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38771118/the-icihhv-6-sense-sensing-the-source-and-relevance-of-human-herpesvirus-6-hhv-6-dna-in-the-transplant-recipient-with-inherited-chromosomally-integrated-hhv-6
#52
JOURNAL ARTICLE
Madeleine R Heldman, Alexander L Greninger, Joshua A Hill
No abstract text is available yet for this article.
May 21, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38771075/health-care-personnel-workdays-lost-and-direct-health-care-salary-costs-incurred-due-to-covid-19-infection-in-the-age-of-widespread-vaccine-availability
#53
JOURNAL ARTICLE
Liam Townsend, Paddy Gillespie, Jonathan McGrath, Claire Kenny, Colm Bergin, Catherine Fleming
BACKGROUND: Vaccination against coronavirus disease 2019 (COVID-19) can mitigate the burden of health care worker (HCW) infection. We investigate the burden of HCW illness and its associated direct health care personnel costs in the setting of widespread vaccine availability and explore factors influencing these outcomes. METHODS: This multicenter prospective study followed HCWs over an 8-month period from January to August 2023. Data recorded included incident COVID-19 infection, symptom burden, workdays missed, and vaccine history...
May 21, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38768311/reactivation-of-a-transplant-recipient-s-inherited-human-herpesvirus-6-and-implications-to-the-graft
#54
JOURNAL ARTICLE
Leo Hannolainen, Lari Pyöriä, Diogo Pratas, Jouko Lohi, Sandra Skuja, Santa Rasa-Dzelzkaleja, Modra Murovska, Klaus Hedman, Timo Jahnukainen, Maria Fernanda Perdomo
BACKGROUND: The implications of inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) in solid organ transplantation remain uncertain. Although this trait has been linked to unfavorable clinical outcomes, an association between viral reactivation and complications has only been conclusively established in a few cases. In contrast to these studies, which followed donor-derived transmission, our investigation is the first to examine the pathogenicity of a recipient´s iciHHV-6B and its impact on the graft...
May 20, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38768246/the-importance-of-including-long-covid-outcomes-when-developing-novel-treatments-for-acute-covid-19
#55
JOURNAL ARTICLE
Chloe Connor, Holly A Taylor
The ongoing COVID-19 pandemic continues to present surges in infections demonstrating the persistent threat posed by COVID-19. Amidst efforts to develop effective treatments for acute COVID-19, there is a growing recognition of the need to address Long COVID. This manuscript reviews the current landscape of acute COVID-19 treatments and highlights the opportunity to incorporate Long COVID as a key outcome measure in clinical trials. Our analysis includes a review of current US clinical trials investigating acute COVID-19 treatments...
May 20, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38758135/maternal-bcg-scars-and-mortality-risk-for-male-and-female-newborns-observational-study-from-guinea-bissau
#56
JOURNAL ARTICLE
Frederik Schaltz-Buchholzer, Sebastian Nielsen, Marcus Kjær Sørensen, Gabriel Marciano Gomes, Simon Hoff, Anna Memborg Toft, Elise Brenno Stjernholm, Ivan Monteiro, Peter Aaby, Christine Stabell Benn
BACKGROUND: Maternal priming with Bacille Calmette-Guérin (BCG) has been associated with reduced mortality in male offspring. We investigated this association in a cohort of healthy BCG-vaccinated neonates. METHODS: Observational study within a randomized controlled trial comparing different BCG strains conducted in Guinea-Bissau from 2017-2020. As part of trial inclusion procedures, on the day of discharge from the maternity ward, maternal BCG scar status was evaluated by visual inspection, followed by offspring BCG and polio vaccination...
May 17, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38753340/the-risk-of-sars-cov-2-transmission-in-community-indoor-settings-a-systematic-review-and-meta-analysis
#57
JOURNAL ARTICLE
Mark Rohit Francis, Saheed Gidado, J Pekka Nuorti
BACKGROUND: Quantifying the risk of SARS-CoV-2 transmission in indoor settings is crucial for developing effective non-vaccine prevention strategies and policies. However, summary evidence on the transmission risks in settings other than households, schools, elderly care and healthcare facilities is limited. We conducted a systematic review to estimate the secondary attack rates (SARs) of SARS-CoV-2 and the factors modifying transmission risk in community indoor settings. METHODS: We searched Medline, Scopus, Web of Science, WHO COVID-19 Research Database, MedrXiv, and BiorXiv from January 1, 2020, to February 20, 2023...
May 16, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38752389/extended-spectrum-beta-lactamase-shigella-sonnei-cluster-among-men-who-have-sex-with-men-in-chicago-illinois-july-october-2022
#58
JOURNAL ARTICLE
Emily A G Faherty, Kendall Kling, Hannah J Barbian, Chao Qi, Shana Altman, Vineet K Dhiman, Richard Teran, Kendall Anderson, Deniz Yuce, Shamika Smith, Morgan Richardson, Kara Vogelzang, Isaac Ghinai, Peter Ruestow, Ira Heimler, Adil Menon, Louise K Francois Watkins, Naeemah Logan, Do Young Kim, Massimo Pacilli, Janna Kerins, Stephanie Black
Drug-resistant shigellosis is increasing, particularly among men who have sex with men (MSM). During July-October 2022, an extended-spectrum beta-lactamase producing Shigella sonnei cluster of 9 patients was identified in Chicago, of whom 8 were MSM and 6 were festival attendees. The cluster also included 4 domestic travelers to Chicago. Sexual health care for MSM should include shigellosis diagnosis and prevention.
May 16, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38748986/population-effectiveness-of-dolutegravir-implementation-in-uganda-a-prospective-observational-cohort-study-disco-48-week-results
#59
JOURNAL ARTICLE
Suzanne M McCluskey, Winnie R Muyindike, Victoria Nanfuka, Daniel Omoding, Nimusiima Komukama, Ian T Barigye, Lydia Kansiime, Justus Tumusiime, Taing N Aung, Ashley Stuckwisch, Bethany Hedt-Gauthier, Vincent C Marconi, Mahomed-Yunus S Moosa, Deenan Pillay, Jennifer Giandhari, Richard Lessells, Ravindra K Gupta, Mark J Siedner
BACKGROUND: Tenofovir/lamivudine/dolutegravir (TLD) is the preferred first-line antiretroviral therapy (ART) regimen for people with HIV (PWH), including those who were previously virologically suppressed on non-nucleoside reverse transcriptase inhibitors (NNRTIs). We sought to estimate the real-world effectiveness of the TLD transition in Ugandan public-sector clinics. METHODS: We conducted a prospective cohort study of PWH ≥18 years who were transitioned from NNRTI-based ART to TLD...
May 16, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38743816/longitudinal-analysis-of-nursing-home-residents-t-cell-responses-after-sars-cov-2-mrna-vaccinations-shows-influence-of-biological-sex-and-sars-cov-2-infection-history
#60
JOURNAL ARTICLE
Carson L Smith, Elise Didion, Htin Aung, Banumathi Tamilselvan, Taissa Bej, Oladayo Oyebanji, Carey L Shive, Brigid M Wilson, Mark Cameron, Cheryl Cameron, Stefan Gravenstein, David Canaday
BACKGROUND: Vaccines and vaccine boosting have blunted excess morbidity and mortality from SARS-CoV-2 infection suffered by older nursing home residents (NHR). However, the impact of repeated vaccination on the T cell response based on biological sex and prior infection of NHR remain understudied. METHODS: We examined T cell responses to mRNA vaccines to SARS-CoV-2 in a cohort of NHR and healthcare workers (HCW) over 2 years. We used IFN-γ ELIspot and flow cytometry to assess T cell response before, two weeks and 6 months after the initial series and each of two booster vaccines...
May 14, 2024: Journal of Infectious Diseases
journal
journal
20154
3
4
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.