journal
https://read.qxmd.com/read/38717937/identification-of-two-novel-subtypes-of-hepatitis-c-virus-genotype-8-and-a-potential-new-genotype-successfully-treated-with-direct-acting-antivirals
#21
JOURNAL ARTICLE
Jean L Mbisa, Zena Lapp, David F Bibby, Laura T Phillips, Carmen F Manso, Simon Packer, Ruth Simmons, Kathryn Harris, Jaiganesh Mohan, Lalitha Chinnappan, Thomas Leitner, Daniel Bradshaw
BACKGROUND: Hepatitis C virus (HCV) has a high genetic diversity and is classified into 8 genotypes and over 90 subtypes with some endemic to specific world regions. This could compromise direct-acting antiviral (DAA) efficacy and global HCV elimination. METHODS: We characterised HCV subtypes 'rare' to the UK (non-1a/1b/2b/3a/4d) by whole genome sequencing via a national surveillance programme. Genetic analyses to determine the genotype of samples with unresolved genotypes were undertaken by comparison with ICTV HCV reference sequences...
May 8, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38717928/risk-of-severe-acute-respiratory-syndrome-coronavirus-2-infection-following-prior-infection-or-vaccination
#22
JOURNAL ARTICLE
Joseph E Ebinger, Nancy Sun, Sandy Y Joung, John Michael S Sanchez, Minhao Wang, Yunxian Liu, John C Prostko, Edwin C Frias, James L Stewart, Mallory Heath, Brian L Claggett, Susan Cheng, Kimia Sobhani
BACKGROUND: The extent to which infection versus vaccination has conferred similarly durable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity during the Omicron era remains unclear. METHODS: In a cohort of 4496 adults under continued serological surveillance throughout the first year of Omicron-predominant SARS-CoV-2 transmission, we examined incidence of new infection among individuals whose last known antigenic exposure was either recent (<90 days) or remote (≥90 days) infection or vaccination...
May 8, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38716969/characterization-of-treatment-resistance-and-viral-kinetics-in-the-setting-of-single-versus-dual-active-monoclonal-antibodies-against-sars-cov-2
#23
JOURNAL ARTICLE
Manish C Choudhary, Rinki Deo, Teresa H Evering, Kara W Chew, Mark J Giganti, Carlee Moser, Justin Ritz, James Regan, James P Flynn, Charles R Crain, David Alain Wohl, Judith S Currier, Joseph J Eron, David Margolis, Qing Zhu, Lijie Zhon, Li Ya, Alexander L Greninger, Michael D Hughes, Davey Smith, Eric S Daar, Jonathan Z Li
BACKGROUND: Monoclonal antibodies (mAbs) represent a crucial antiviral strategy for SARS-CoV-2 infection, but it is unclear whether combination mAbs offer a benefit over single-active mAb treatment. Amubarvimab and romlusevimab significantly reduced the risk of hospitalizations or death in the ACTIV-2/A5401 trial. Certain SARS-CoV-2 variants are intrinsically resistant against romlusevimab, leading to only single-active mAb therapy with amubarvimab in these variants. We evaluated virologic outcomes in individuals treated with single- versus dual-active mAbs...
May 8, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38716762/triggering-toll-like-receptor-5-signaling-during-pneumococcal-superinfection-prevents-the-selection-of-antibiotic-resistance
#24
JOURNAL ARTICLE
Charlotte Costa, Jean-Claude Sirard, Paddy S Gibson, Jan-Willem Veening, Erida Gjini, Mara Baldry
Toll-like receptor 5 (TLR5) signaling plays a key role in antibacterial defenses. We previously showed that respiratory administration of flagellin, a potent TLR5 agonist, in combination with amoxicillin improves the treatment of primary pneumonia or superinfection caused by amoxicillin-sensitive or -resistant Streptococcus pneumoniae. Here, the impact of adjunct flagellin therapy on antibiotic dose/regimen and the selection of antibiotic-resistant S. pneumoniae was investigated using superinfection with isogenic antibiotic-sensitive and -resistant bacteria and population dynamics analysis...
May 8, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38713594/a-genome-wide-association-study-of-susceptibility-to-upper-urinary-tract-infections
#25
JOURNAL ARTICLE
Helene M Flatby, Anuradha Ravi, Kristin V Liyanarachi, Jan E Afset, Humaira Rasheed, Ben M Brumpton, Kristian Hveem, Bjørn O Åsvold, Andrew T DeWan, Erik Solligård, Jan K Damås, Tormod Rogne
BACKGROUND: Our goal was to identify genetic and modifiable risk factors for upper urinary tract infections (UTIs). METHODS: We used data from UK Biobank, The Trøndelag Health Study (HUNT), and Michigan Genomics Initiative (MGI) to conduct genome-wide association studies (GWASs) and sex-stratified analyses on upper UTI. Mendelian randomization (MR) analyses were conducted to examine potential causal relationships between cardiometabolic risk factors and upper UTIs...
May 7, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38713583/visceral-leishmaniasis-human-immunodeficiency-virus-coinfected-patients-are-highly-infectious-to-sandflies-in-an-endemic-area-in-india
#26
JOURNAL ARTICLE
Om Prakash Singh, Rahul Chaubey, Anurag Kumar Kushwaha, Michael P Fay, David Sacks, Shyam Sundar
In an area endemic with Indian visceral leishmaniasis (VL), we performed direct xenodiagnosis to evaluate the transmission of Leishmania donovani from patients with VL-human immunodeficiency virus (HIV) coinfection to the vector sandflies, Phlebotomus argentipes. Fourteen patients with confirmed VL-HIV coinfection, with a median parasitemia of 42 205 parasite genome/mL of blood, were exposed to 732 laboratory-reared pathogen-free female P argentipes sandflies on their lower arms and legs. Microscopy revealed that 16...
May 7, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38712965/response-to-geoffrey-dow-and-bryan-smith-on-a-proposed-tafenoquine-treatment-trial-for-babesiosis
#27
JOURNAL ARTICLE
Choukri Ben Mamoun, Gary P Wormser
No abstract text is available yet for this article.
May 7, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38712959/trial-planned-to-evaluate-safety-and-efficacy-of-tafenoquine-atovaquone-azithromycin-in-hospitalized-babesiosis-patients
#28
JOURNAL ARTICLE
Geoffrey Dow, Bryan Smith
No abstract text is available yet for this article.
May 7, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38709726/review-of-the-current-tb-human-infection-studies-for-use-in-accelerating-tb-vaccine-development-a-meeting-report
#29
JOURNAL ARTICLE
Shobana Balasingam, Keertan Dheda, Sarah Fortune, Stephen B Gordon, Daniel Hoft, James G Kublin, Colleen N Loynachan, Helen McShane, Ben Morton, Sujatha Nambiar, Nimisha Raj Sharma, Brian Robertson, Lewis K Schrager, Charlotte L Weller
Tools to evaluate and accelerate tuberculosis (TB) vaccine development are needed to advance global TB control strategies. Validated human infection studies for TB have the potential to facilitate breakthroughs in understanding disease pathogenesis, identify correlates of protection, develop diagnostic tools, and accelerate and de-risk vaccine and drug development. However, key challenges remain for realizing the clinical utility of these models, which require further discussion and alignment amongst key stakeholders...
May 6, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38709708/transcriptomic-signatures-of-progression-to-tb-disease-among-close-contacts-in-brazil
#30
JOURNAL ARTICLE
Simon C Mendelsohn, Bruno B Andrade, Stanley Kimbung Mbandi, Alice M S Andrade, Vanessa M Muwanga, Marina C Figueiredo, Mzwandile Erasmus, Valeria C Rolla, Prisca K Thami, Marcelo Cordeiro-Santos, Adam Penn-Nicholson, Afranio L Kritski, Mark Hatherill, Timothy R Sterling, Thomas J Scriba
BACKGROUND: Approximately 5% of people infected with Mycobacterium tuberculosis progress to tuberculosis (TB) disease without preventive therapy. There is a need for a prognostic test to identify those at highest risk of incident TB, so that therapy can be targeted. We evaluated host blood transcriptomic signatures for progression to TB disease. METHODS: Close contacts (≥4 hours exposure per week) of adult patients with culture-confirmed pulmonary TB were enrolled in Brazil...
May 6, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38700101/drug-concentrations-in-hair-and-dried-blood-spots-as-prep-adherence-metrics-during-pregnancy-and-postpartum
#31
JOURNAL ARTICLE
Linxuan Wu, John Kinuthia, Peter L Anderson, Jared M Baeten, Julia C Dettinger, Monica Gandhi, Laurén Gomez, Grace John-Stewart, Mary M Marwa, Nancy Ngumbau, Felix Otieno, Pascal Omondi, Ben Odhiambo, Salphine Watoyi, Jillian Pintye
We evaluated hair tenofovir (TFV) concentrations as an adherence metric for HIV pre-exposure prophylaxis (PrEP) during pregnancy and postpartum and compared hair levels with tenofovir-diphosphate (TFV-DP) levels in dried blood spots (DBS). Overall, 152 hair samples from 102 women and 36 hair-DBS paired samples from 29 women were collected from a subset of women in a cluster randomized trial. Having a partner known to be living with HIV was associated with higher hair TFV levels (p<0.001). Hair TFV concentrations were strongly correlated with DBS TFV-DP levels (r=0...
May 3, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38696727/the-benefits-of-medically-tailored-meals-for-people-living-with-hiv
#32
JOURNAL ARTICLE
Seth A Berkowitz
No abstract text is available yet for this article.
May 2, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38696724/food-is-medicine-for-hiv-improved-health-and-hospitalizations-in-the-changing-health-through-food-support-chefs-hiv-pragmatic-randomized-trial
#33
JOURNAL ARTICLE
Kartika Palar, Lila A Sheira, Edward A Frongillo, Asher A O'Donnell, Tessa M Nápoles, Mark Ryle, Simon Pitchford, Kim Madsen, Beth Phillips, Elise D Riley, Sheri D Weiser
BACKGROUND: Policy support for "Food is Medicine"-medically tailored meals or groceries to improve health-is rapidly growing. No randomized trials have heretofore investigated the benefits of medically tailored food programs for people living with HIV (PLHIV). METHODS: The CHEFS-HIV pragmatic randomized trial included PLHIV who were clients of Project Open Hand (POH), a San Francisco-based nonprofit food organization. The intervention arm (n = 93) received comprehensive medically tailored meals, groceries, and nutritional education...
May 2, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38696336/validation-of-an-automated-end-to-end-metagenomic-sequencing-assay-for-agnostic-detection-of-respiratory-viruses
#34
JOURNAL ARTICLE
Nick P G Gauthier, Wilson Chan, Kerstin Locher, Duane Smailus, Robin Coope, Marthe Charles, Agatha Jassem, Jennifer Kopetzky, Samuel D Chorlton, Amee R Manges
BACKGROUND: Current molecular diagnostics are limited in the number and type of detectable pathogens. Metagenomic next generation sequencing (mNGS) is an emerging, and increasingly feasible, pathogen-agnostic diagnostic approach. Translational barriers prohibit the widespread adoption of this technology in clinical laboratories. We validate an end-to-end mNGS assay for detection of respiratory viruses. Our assay is optimized to reduce turnaround time, lower cost-per-sample, increase throughput, and deploy secure and actionable bioinformatic results...
May 2, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38696335/rhabdomyolysis-acute-kidney-injury-and-mortality-in-ebola-virus-disease-retrospective-analysis-of-cases-from-eastern-democratic-republic-of-the-congo-2019
#35
JOURNAL ARTICLE
Kasereka Masumbuko Claude, Daniel Mukadi-Bamuleka, Richard Kitenge-Omasumbu, François Edidi-Atani, Meris Matondo Kuamfumu, Sabue Mulangu, Olivier Tshiani-Mbaya, Kambale Malengera Vicky, Placide Mbala-Kingebeni, Steve Ahuka-Mundeke, Jean-Jacques Muyembe-Tamfum, Bonita E Lee, Stan Houston, Zubia Mumtaz, Michael T Hawkes
BACKGROUND: Skeletal muscle injury in Ebola virus disease (EVD) has been reported, but its association with morbidity and mortality remains poorly defined. METHODS: Retrospective study of patients admitted to two EVD Treatment Units, over an eight-month period in 2019, during a large EVD epidemic in the Democratic Republic of the Congo. RESULTS: 333 patients (median age 30 years, 58% female) had at least one creatine kinase (CK) measurement (total 2,229 CK measurements, median 5 (IQR 1-11) per patient)...
May 2, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38687898/reduced-effectiveness-of-repeat-influenza-vaccination-distinguishing-among-within-season-waning-recent-clinical-infection-and-subclinical-infection
#36
JOURNAL ARTICLE
Qifang Bi, Barbra A Dickerman, Huong Q Nguyen, Emily T Martin, Manjusha Gaglani, Karen J Wernli, G K Balasubramani, Brendan Flannery, Marc Lipsitch, Sarah Cobey
Studies have reported that prior-season influenza vaccination is associated with higher risk of clinical influenza infection among vaccinees. This effect might arise from incomplete consideration of within-season waning and recent infection. Using data from the US Flu Vaccine Effectiveness (VE) Network (2011-2012 to 2018-2019 seasons), we found that repeat vaccinees were vaccinated earlier in a season by one week. After accounting for waning VE, repeat vaccinees were still more likely to test positive for A(H3N2) (OR=1...
April 30, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38687883/genomic-diversity-and-antimicrobial-susceptibility-of-invasive-neisseria-meningitidis-in-south-africa-2016-2021
#37
JOURNAL ARTICLE
Rito L Mikhari, Susan Meiring, Linda de Gouveia, Wai Yin Chan, Keith A Jolley, Daria Van Tyne, Lee H Harrison, Henju Marjuki, Arshad Ismail, Vanessa Quan, Cheryl Cohen, Sibongile Walaza, Anne von Gottberg, Mignon du Plessis
BACKGROUND: Invasive meningococcal isolates in South Africa have in previous years (<2008) been characterized by serogroup B, C, W and Y lineages over time, with penicillin intermediate resistance (peni) at 6%. We describe the population structure and genomic markers of peni among invasive meningococcal isolates in South Africa, 2016-2021. METHODS: Meningococcal isolates were collected through national, laboratory-based invasive meningococcal disease (IMD) surveillance...
April 30, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38687212/effect-of-leptin-receptor-q223r-polymorphism-on-clostridioides-difficile-infection-induced-macrophage-migration-inhibitory-factor-production
#38
JOURNAL ARTICLE
Ann M Mathew, Alexander Huber, Rowis D Sous, Kristin N Weghorn, Margaret V Powers-Fletcher, Shinsmon Jose, Rajat Madan
Proinflammatory cytokine levels and host genetic makeup are key determinants of Clostridioides difficile infection (CDI) outcomes. We previously reported that blocking the inflammatory cytokine macrophage migration inhibitory factor (MIF) ameliorates CDI. Here, we determined kinetics of MIF production and its association with a common genetic variant in leptin receptor (LEPR) using blood from patients with CDI. We found highest plasma MIF early after C difficile exposure and in individuals who express mutant/derived LEPR...
April 30, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38687181/longitudinal-evaluation-of-sars-cov-2-t-cell-immunity-over-2-years-following-vaccination-and-infection
#39
JOURNAL ARTICLE
Anna Karina Juhl, Lisa Loksø Dietz, Ole Schmeltz Søgaard, Joanne Reekie, Henrik Nielsen, Isik Somuncu Johansen, Thomas Benfield, Lothar Wiese, Nina Breinholt Stærke, Tomas Østergaard Jensen, Rikke Olesen, Kasper Iversen, Kamille Fogh, Jacob Bodilsen, Lone Wulff Madsen, Susan Olaf Lindvig, Dorthe Raben, Sidsel Dahl Andersen, Astrid Korning Hvidt, Signe Rode Andreasen, Eva Anna Marianne Baerends, Jens Lundgren, Lars Østergaard, Martin Tolstrup
BACKGROUND: Within a year of the SARS-CoV-2 pandemic, vaccines inducing a robust humoral and cellular immune response were implemented worldwide. However, emergence of novel variants and waning vaccine induced immunity led to implementation of additional vaccine boosters. METHODS: This prospective study evaluated the temporal profile of cellular and serological responses in a cohort of 639 SARS-CoV-2 vaccinated participants, of whom a large proportion experienced a SARS-CoV-2 infection...
April 30, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38682569/efficacy-and-safety-of-a-tetravalent-dengue-vaccine-tak-003-in-children-with-prior-japanese-encephalitis-or-yellow-fever-vaccination
#40
JOURNAL ARTICLE
Chukiat Sirivichayakul, Shibadas Biswal, Xavier Saez-Llorens, Eduardo López-Medina, Charissa Borja-Tabora, Lulu Bravo, Pope Kosalaraksa, Maria Theresa Alera, Humberto Reynales, Luis Rivera, Veerachai Watanaveeradej, Delia Yu, Felix Espinoza, Reynaldo Dietze, LakKumar Fernando, V Pujitha Wickramasinghe, Edson Duarte Moreira, Asvini D Fernando, Dulanie Gunasekera, Kleber Luz, Rivaldo Venâncio da Cunha, Ana Lucia Oliveira, Martina Rauscher, Huihao Fan, Astrid Borkowski, Ian Escudero, Suely Tuboi, Eric Lloyd, Vianney Tricou, Nicolas Folschweiller, Inge LeFevre, Luis Martinez Vargas, Derek Wallace
BACKGROUND: We explored the impact of prior Yellow fever (YF) or Japanese encephalitis (JE) vaccination on the efficacy of Takeda's dengue vaccine candidate, TAK-003 (NCT02747927). METHODS: Children 4-16 years of age were randomized 2:1 to receive TAK-003 or placebo and were under active febrile surveillance. Symptomatic dengue was confirmed by serotype-specific RT-PCR. YF and JE vaccination history was recorded. RESULTS: Of the 20,071 children who received TAK-003 or placebo, 21...
April 29, 2024: Journal of Infectious Diseases
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