journal
https://read.qxmd.com/read/36436610/liver-related-aspects-of-gene-therapy-for-haemophilia-call-to-action-for-collaboration-between-haematologists-and-hepatologists
#1
JOURNAL ARTICLE
Wolfgang Miesbach, Graham R Foster, Flora Peyvandi
No abstract text is available yet for this article.
November 24, 2022: Journal of Hepatology
https://read.qxmd.com/read/36435298/unmasking-of-a-hepatitis-c-genotype-3a-1b-dual-infection-in-an-individual-treated-with-elbasvir-grazoprevir
#2
LETTER
Rob W van der Pluijm, Loek P Smits, Sjoerd P Rebers, Janke Schinkel, Marc van der Valk
No abstract text is available yet for this article.
November 23, 2022: Journal of Hepatology
https://read.qxmd.com/read/36427656/integrating-genetic-variants-into-clinical-models-for-hepatocellular-carcinoma-risk-stratification-in-cirrhosis
#3
JOURNAL ARTICLE
Pierre Nahon, Jessica Bamba-Funck, Richard Layese, Eric Trépo, Jessica Zucman-Rossi, Carole Cagnot, Nathalie Ganne-Carrié, Cendrine Chaffaut, Erwan Guyot, Marianne Ziol, Angela Sutton, Etienne Audureau
BACKGROUND AND AIMS: This study aimed to evaluate the ability of single nucleotide polymorphisms (SNPs) to refine hepatocellular carcinoma (HCC) risk stratification. METHODS: Six SNPs in PNPLA3, TM6SF2, HSD17B13, APOE, and MBOAT7 affecting lipid turnover and one variant involved in the Wnt-β-catenin pathway (WNT3A-WNT9A rs708113) were assessed in patients with alcohol-related and/or HCV-cured cirrhosis included in HCC surveillance programs (prospective CirVir and CIRRAL cohorts)...
November 22, 2022: Journal of Hepatology
https://read.qxmd.com/read/36423805/low-alcohol-consumption-influences-outcomes-in-individuals-with-alcohol-related-compensated-cirrhosis-in-a-french-multicenter-cohort
#4
JOURNAL ARTICLE
Alexandre Louvet, Valérie Bourcier, Isabelle Archambeaud, Louis d'Alteroche, Cendrine Chaffaut, Frédéric Oberti, Christophe Moreno, Dominique Roulot, Thông Dao, Romain Moirand, Jean-Charles Duclos-Vallée, Odile Goria, Eric Nguyen-Khac, Stanislas Pol, Nicolas Carbonell, Jérôme Gournay, Laure Elkrief, Isabelle Fouchard-Hubert, Sylvie Chevret, Nathalie Ganne-Carrié
BACKGROUND AND AIMS: The harmful impact of heavy alcohol recurrence has been confirmed in patients with alcohol-related cirrhosis although this is based on old studies. The drivers of long-term outcome still need to be clearly investigated. METHOD: All patients with biopsy-proven compensated alcohol-related cirrhosis included in the CIRRAL cohort (22 centers) were prospectively studied. Prognostic variables of survival and liver event-free survival were assessed using multivariable Cox models with stepwise selection...
November 21, 2022: Journal of Hepatology
https://read.qxmd.com/read/36410555/prospective-surveillance-for-cholangiocarcinoma-in-unselected-individuals-with-primary-sclerosing-cholangitis
#5
JOURNAL ARTICLE
Christina Villard, Ingalill Friis-Liby, Fredrik Rorsman, Karouk Said, Anna Warnqvist, Martin Cornillet, Stergios Kechagias, Nils Nyhlin, Mårten Werner, Izabella Janczewska, Therese Hagström, Emma Nilsson, Annika Bergquist
BACKGROUND: The evidence for hepatobiliary tumour surveillance in patients with primary sclerosing cholangitis (PSC) is scarce. This study aimed to prospectively evaluate cholangiocarcinoma (CCA) surveillance with yearly magnetic resonance imaging including cholangiopancreatography (MRI/MRCP) in a nationwide cohort. METHODS: In total, 512 PS C patients from 11 Swedish hospitals were recruited. The study protocol included yearly clinical follow-ups, liver function tests and contrast-enhanced MRI/MRCP and carbohydrate antigen (CA) 19-9...
November 18, 2022: Journal of Hepatology
https://read.qxmd.com/read/36410554/a-prospective-study-on-the-prevalence-of-nafld-advanced-fibrosis-cirrhosis-and-hepatocellular-carcinoma-in-people-with-type-2-diabetes
#6
JOURNAL ARTICLE
Veeral Ajmera, Sandra Cepin, Kaleb Tesfai, Heather Hofflich, Karen Cadman, Scarlett Lopez, Egbert Madamba, Ricki Bettencourt, Lisa Richards, Cynthia Behling, Claude B Sirlin, Rohit Loomba
BACKGROUND: There are limited prospective data in a United States cohort of patients with type 2 diabetes mellitus (T2DM) specifically enrolled and systematically assessed for advanced fibrosis or cirrhosis due to nonalcoholic fatty liver disease (NAFLD). Therefore, we aimed to evaluate the prevalence of advanced fibrosis and cirrhosis in a prospectively recruited cohort of adults with T2DM. METHODS: This prospective study enrolled adults age ≥ 50 years with T2DM recruited from primary care or endocrinology clinics...
November 18, 2022: Journal of Hepatology
https://read.qxmd.com/read/36402452/the-concept-of-mafld-gathers-patients-with-distinct-disease-progression-trajectories
#7
LETTER
Pierre Deltenre, Eric Trépo, Christophe Moreno
No abstract text is available yet for this article.
November 16, 2022: Journal of Hepatology
https://read.qxmd.com/read/36402451/value-of-threshold-growth-as-a-major-diagnostic-feature-of-hepatocellular-carcinoma-in-li-rads
#8
JOURNAL ARTICLE
Se Jin Choi, Sang Hyun Choi, Dong Wook Kim, Minha Kwag, Jae Ho Byun, Hyung Jin Won, Yong Moon Shin
BACKGROUND & AIMS: The Liver Reporting and Data System (LI-RADS) version 2018 simplified the definition of threshold growth to '≥50% size increase in a mass in ≤6 months. However, the diagnostic value of threshold growth for HCC remained unclear. We evaluated the value of threshold growth, as defined by the LI-RADS v2018, in diagnosing HCCs. METHODS: Patients who underwent preoperative gadoxetate disodium-enhanced MRI because of the presence of LI-RADS category 2, 3, or 4 rather than category 5 on prior CT/MRI between January 2017 and December 2020 were retrospectively evaluated...
November 16, 2022: Journal of Hepatology
https://read.qxmd.com/read/36402450/longitudinal-changes-in-fibrosis-markers-are-associated-with-risk-of-cirrhosis-and-hepatocellular-carcinoma-in-non-alcoholic-fatty-liver-disease
#9
JOURNAL ARTICLE
George Cholankeril, Jennifer R Kramer, Jinna Chu, Xian Yu, Maya Balakrishnan, Liang Li, Hashem El-Serag, Fasiha Kanwal
BACKGROUND & AIMS: We aim to evaluate the association between longitudinal changes in noninvasive tests for liver fibrosis such as FIB-4 over time and subsequent risk of hepatocellular carcinoma (HCC) and a composite endpoint of cirrhosis and HCC in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: We conducted a retrospective cohort study of NAFLD patients seen in 130 Veterans Administration hospitals between 1/1/2004-12/31/2008 with follow-up through 12/31/2018...
November 16, 2022: Journal of Hepatology
https://read.qxmd.com/read/36402449/title-on-building-a-better-mousetrap-response-to-towards-optimally-replacing-the-current-version-of-meld
#10
LETTER
Jin Ge, W Ray Kim, Jennifer C Lai, Allison J Kwong
No abstract text is available yet for this article.
November 16, 2022: Journal of Hepatology
https://read.qxmd.com/read/36402448/biejia-ruangan-compound-and-incidence-of-hepatocellular-carcinoma
#11
LETTER
Lei Luo, Xuebing Yao, Wenlong Yang
No abstract text is available yet for this article.
November 16, 2022: Journal of Hepatology
https://read.qxmd.com/read/36400328/integrating-cytotoxic-targeted-and-immune-therapies-for-cholangiocarcinoma
#12
REVIEW
Joachim Merters, Angela Lamarca
Management of BTCs is rapidly evolving. Majority of patients are diagnosed with advanced disease, when chemotherapy with cisplatin and gemcitabine followed by second-line FOLFOX is the cornerstone of treatment in the absence of targetable alterations. Targeted therapies for tumours harbouring fibroblast growth factor receptor-2 (FGFR-2) fusions, isocitrate dehydrogenase-1 (IDH-1) mutations, BRAF V600E mutations, NTRK fusions and/or HER2 amplifications, among others, have brought precision medicine into the treatment landscape of advanced BTC...
November 15, 2022: Journal of Hepatology
https://read.qxmd.com/read/36400327/albumin-for-liver-brain-outcome-improvement-across-different-situations-in-cirrhosis
#13
LETTER
Jasmohan S Bajaj
No abstract text is available yet for this article.
November 15, 2022: Journal of Hepatology
https://read.qxmd.com/read/36375686/enhanced-diagnosis-of-advanced-fibrosis-and-cirrhosis-in-individuals-with-nafld-using-fibroscan-based-agile-scores
#14
JOURNAL ARTICLE
Arun J Sanyal, Julie Foucquier, Zobair M Younossi, Stephen A Harrison, Philip N Newsome, Wah-Keong Chan, Yusuf Yilmaz, Victor De Ledinghen, Charlotte Costentin, Ming-Hua Zheng, Vincent Wai-Sun Wong, Magdy Elkhashab, Ryan S Huss, Robert P Myers, Marine Roux, Aymeric Labourdette, Marie Destro, Céline Fournier-Poizat, Véronique Miette, Laurent Sandrin, Jérôme Boursier
BACKGROUND & AIMS: Currently available non-invasive tests, including FIB-4 and liver stiffness measurement (LSM by VCTE), are highly effective in excluding advanced fibrosis (AF) or cirrhosis yet their ability to rule in is moderate. Our objective was to develop and validate two new scores (Agile 4 and Agile 3+), combining LSM with routine clinical parameters to identify cirrhosis or AF, respectively, in those with NAFLD in specialized liver clinics, with optimized positive predictive value (PPV) and reduced number of cases with indeterminate results...
November 11, 2022: Journal of Hepatology
https://read.qxmd.com/read/36372119/normothermic-liver-machine-perfusion-as-a-dynamic-platform-for-assessment-and-treatment-of-organs-from-septic-donors
#15
LETTER
Felix J Krendl, Rupert Oberhuber, Robert Breitkopf, Günter Weiss, Stefan Schneeberger
No abstract text is available yet for this article.
November 10, 2022: Journal of Hepatology
https://read.qxmd.com/read/36370953/enoxaparin-is-safe-and-effective-for-restoring-and-preserving-forward-portal-venous-flow-in-children-with-end-stage-liver-disease
#16
LETTER
Shreya B Kishore, Peter Lewindon, Charlton Noble, Fariha Balouch
No abstract text is available yet for this article.
November 9, 2022: Journal of Hepatology
https://read.qxmd.com/read/36370952/prediction-of-liver-related-mortality-in-a-community-setting
#17
LETTER
Carolin V Schneider, Stefan Gross, Pavel Strnad
No abstract text is available yet for this article.
November 9, 2022: Journal of Hepatology
https://read.qxmd.com/read/36370951/assessing-causal-relationship-between-non-alcoholic-fatty-liver-disease-and-risk-of-atrial-fibrillation
#18
LETTER
Ziang Li, Bin Zhang, Jinyue Li, Zhihang Tao, Yongjian Wu
No abstract text is available yet for this article.
November 9, 2022: Journal of Hepatology
https://read.qxmd.com/read/36370950/mefib-vs-mast-and-fast-not-a-competition-but-useful-tools
#19
LETTER
Mazen Noureddin, Stephen A Harrison, Naim Alkhouri
No abstract text is available yet for this article.
November 9, 2022: Journal of Hepatology
https://read.qxmd.com/read/36370949/lysophosphatidylcholines-modulate-immunoregulatory-checkpoints-in-peripheral-monocytes-and-are-associated-with-mortality-in-people-with-acute-liver-failure
#20
JOURNAL ARTICLE
Francesca M Trovato, Rabiya Zia, Florent Artru, Salma Mujib, Ellen Jerome, Anna Cavazza, Muireann Coen, Ian Wilson, Elaine Holmes, Phillip Morgan, Arjuna Singanayagam, Christine Bernsmeier, Salvatore Napoli, William Bernal, Julia Wendon, Rosa Miquel, Krishna Menon, Vishal C Patel, John Smith, Stephen R Atkinson, Evangelos Triantafyllou, Mark Jw McPhail
BACKGROUND AND AIMS: Acute liver failure (ALF) is a life-threatening disease characterised by high-grade inflammation and immunoparesis with a high incidence of death from sepsis. Here, we aimed to describe the metabolic dysregulation in ALF and determine whether systemic immune responses are modulated via the lysophosphatidylcholine(LPC)-autotaxin(ATX)-lysophosphatidylcholinic acid (LPA) pathway. METHODS: 96 ALF patients, 71 healthy controls (HC), 104 patients with cirrhosis and 31 septic patients were recruited...
November 9, 2022: Journal of Hepatology
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