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Wenshi Wang, Florian A Lempp, Franziska Schlund, Lisa Walter, Charlotte Decker, Zhenfeng Zhang, Yi Ni, Stephan Urban
BACKGROUND & AIMS: Chronic hepatitis D virus (HDV) infections cause the most severe form of viral hepatitis. HDV requires hepatitis B virus (HBV) envelope proteins for hepatocyte entry, particle assembly and release. Eight HDV and eight HBV genotypes are presently distinguished. However, comparing data of replication competence of HDV isolated from different genotypes lacks. Furthermore, it is unknown to what extent combination with different HBV envelopes affect virion assembly and infectivity...
April 9, 2021: Journal of Hepatology
#2
Kristin Ashby, Wei Zhuang, Andres González-Jimenez, Ismael Alvarez-Alvarez, M Isabel Lucena, Raúl J Andrade, Guruprasad P Aithal, Ayako Suzuki, Minjun Chen
BACKGROUND & AIMS: Although most drug-induced liver injury (DILI) cases resolve after the culprit medication is discontinued, time to recovery varies among patients, with 6-12% developing a chronic disease. Here, we investigated clinical factors and drug properties as potential risk determinants that influence the time course for DILI recovery and developed a model to predict its trajectory. METHODS: We applied an accelerated failure time model to 294 cases collected by the International Drug-Induced Liver Network Consortium (iDILIC)...
April 9, 2021: Journal of Hepatology
#3
Javier Martínez, Virginia Hernández-Gea, Enrique Rodríguez-de-Santiago, Luis Téllez, Bogdan Procopet, Álvaro Giráldez, Lucio Amitrano, Candid Villanueva, Dominique Thabut, Luis Ibañez-Samaniego, Gilberto Silva-Junior, Joan Genescà, Christophe Bureau, Jonel Trebicka, Rafael Bañares, Aleksander Krag, Elba Llop, Wim Laleman, Jose María Palazon, Jose Castellote, Susana Rodrigues, Lise L Gluud, Carlos Noronha-Ferreira, Nuria Cañete, Manuel Rodríguez, Arnulf Ferlitsch, Remy Schwarzer, Jose Luis Mundi, Henning Gronbaek, Manuel Hernández-Guerra, Romano Sassatelli, Alessandra Dell Era, Marco Senzolo, Juan G Abraldes, Manuel Romero-Gomez, Alexander Zipprich, Meritxell Casas, Helena Masnou, Massimo Primignani, Frederik Nevens, Jose Luis Calleja, Christian Jansen, Marie Angèle Robic, Irene Conejo, Maria Vega Catalina, Marika Rudler, Edilmar Alvarado, Valeria Perez-Campuzano, Maria Anna Guardascione, Petra Fischer, Jaime Bosch, Juan Carlos García-Pagán, Agustín Albillos
BACKGROUND AND AIMS: Antibiotic prophylaxis reduces the risk of infection and mortality in cirrhotic patients with acute variceal bleeding (AVB). This study examines the incidence and risk factors of bacterial infections during hospitalization in patients with AVB on antibiotic prophylaxis. METHODS: Post-hoc analysis of the database of an international, multicenter, observational study designed to examine the role of preemptive TIPS in patients with cirrhosis and AVB...
April 9, 2021: Journal of Hepatology
#4
LETTER
Thorsten Cramer, Peter Vaupel
No abstract text is available yet for this article.
April 8, 2021: Journal of Hepatology
#5
LETTER
Philip Prinz
No abstract text is available yet for this article.
April 5, 2021: Journal of Hepatology
#6
EDITORIAL
Wolfram Gerlich
No abstract text is available yet for this article.
April 2, 2021: Journal of Hepatology
#7
EDITORIAL
Jennifer A Flemming, Maria P Velez
No abstract text is available yet for this article.
March 30, 2021: Journal of Hepatology
#8
LETTER
Verner Eerola, Fredrik Åberg, Ville Sallinen
No abstract text is available yet for this article.
March 29, 2021: Journal of Hepatology
#9
Tobias Poch, Jenny Krause, Christian Casar, Timur Liwinski, Laura Glau, Max Kaufmann, Annika E Ahrenstorf, Leonard U Hess, Annerose E Ziegler, Glòria Martrus, Sebastian Lunemann, Marcial Sebode, Jun Li, Dorothee Schwinge, Christian F Krebs, Andre Franke, Manuel A Friese, Karl J Oldhafer, Lutz Fischer, Marcus Altfeld, Ansgar W Lohse, Samuel Huber, Eva Tolosa, Nicola Gagliani, Christoph Schramm
BACKGROUND AND AIMS: Little is known on the composition of intrahepatic immune cells and their contribution to the pathogenesis of primary sclerosing cholangitis (PSC). We here aimed to create an atlas of intrahepatic T cells and thereby in detail characterize T cells in human inflamed liver. METHODS: Different single-cell RNA sequencing methods were combined with in silico analyses on intrahepatic and peripheral T cells from patients with PSC (n=11) and healthy donors (HD, n=4)...
March 24, 2021: Journal of Hepatology
#10
Elena Corradini, Elena Buzzetti, Paola Dongiovanni, Stefania Scarlini, Angela Caleffi, Serena Pelusi, Isabella Bernardis, Paolo Ventura, Raffaela Rametta, Elena Tenedini, Enrico Tagliafico, Anna Ludovica Fracanzani, Silvia Fargion, Antonello Pietrangelo, Luca Vittorio Valenti
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) is a multifactorial disorder resulting from genetic and environmental factors. Hyperferritinemia has been associated with increased hepatic iron stores and worse outcomes in NAFLD patients. The aim of this study was to evaluate the prevalence of variants of iron-related genes and their association with hyperferritinemia, hepatic iron stores and liver disease severity in NAFLD patients. METHODS: From a cohort of 328 subjects with histological NAFLD, 23 patients with ferritin >750 ng/ml and positive iron staining, and 25 controls with normal ferritin and negative iron staining were selected...
March 24, 2021: Journal of Hepatology
#11
LETTER
Kristi Basho, Dominik Bettinger, Tobias Boettler
No abstract text is available yet for this article.
March 23, 2021: Journal of Hepatology
#12
Jaime Bosch, Guadalupe García Tsao
No abstract text is available yet for this article.
March 23, 2021: Journal of Hepatology
#13
EDITORIAL
Philip J Johnson
No abstract text is available yet for this article.
March 22, 2021: Journal of Hepatology
#14
LETTER
Javier Crespo, Jeffrey V Lazarus, Paula Iruzubieta, Federico García, Javier García-Samaniego
No abstract text is available yet for this article.
March 20, 2021: Journal of Hepatology
#15
LETTER
Aditya Singh, Madhumita Premkumar, Virendra Singh
No abstract text is available yet for this article.
March 19, 2021: Journal of Hepatology
#16
LETTER
Pierre Deltenre, Christophe Moreno, Eric Trépo
No abstract text is available yet for this article.
March 19, 2021: Journal of Hepatology
#17
Elisa Pose, Abiguei Torrents, Enric Reverter, Valeria Perez-Campuzano, Isabel Campos-Varela, Emma Avitabile, Jordi Gratacós-Ginès, Jose Castellote, Lluis Castells, Jordi Colmenero, Jaume Tort, Pere Ginès, Gonzalo Crespo
BACKGROUND AND AIMS: to what extent patients with alcohol-related decompensated cirrhosis can improve until recovery from decompensation remains unclear. We aimed to investigate the probability of recovery and delisting due to improvement in patients with alcohol-related decompensated cirrhosis in the waiting list (WL) for liver transplantation (LT). METHODS: we conducted a registry-based, multicenter, retrospective study including all patients admitted to the LT-WL in Catalonia (Spain) with the indication of alcohol-, HCV-, cholestatic- or NASH- decompensated cirrhosis between January 2007 and December 2018...
March 18, 2021: Journal of Hepatology
#18
Jie Li, Xiaoyun Zhu, Meihui Zhang, Yanqiu Zhang, Shengtao Ye, Yingrong Leng, Ting Yang, Lingyi Kong, Hao Zhang
BACKGROUND & AIMS: Cholestatic liver diseases comprise a variety of disorders of bile formation and/or flow which generally result in progressive hepatobiliary injury. Regulation of the bile acid (BA) synthesis and homeostasis is a promising strategy for the treatment of cholestatic liver disease. Limb expression 1-like protein (LIX1L) plays an important role in post-transcriptional gene regulation, yet its role in cholestatic liver injury remains unclear. METHODS: LIX1L expression was studied in primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC) patients, and three murine models of cholestasis including bile-duct ligation (BDL), Mdr2 knockout (Mdr2-/- ), and cholic acid (CA)-fed mice...
March 18, 2021: Journal of Hepatology
#19
Stephen A Harrison, Samer Gawrieh, Katharine Roberts, Christopher J Lisanti, Ryan B Schwope, Katherine M Cebe, Valerie Paradis, Pierre Bedossa, Jennifer M Aldridge Whitehead, Aymeric Labourdette, Véronique Miette, Stefan Neubauer, Céline Fournier, Angelo H Paredes, Naim Alkhouri
BACKGROUND AND AIMS: Large prospective studies to establish the prevalence of nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH), are lacking. We prospectively assessed the prevalence and severity of NAFLD/NASH in a cohort of asymptomatic middle-aged Americans attending a colonoscopy class at a gastroenterology clinic. METHODS: Screening for NAFLD was performed using magnetic resonance (MR)-based LiverMultiScan® proton density fat fraction (LMS-PDFF)...
March 18, 2021: Journal of Hepatology
#20
Yu A An, Shiuhwei Chen, Yingfeng Deng, Zhao V Wang, Jan-Bernd Funcke, Manasi Shah, Bo Shan, Ruth Gordillo, Jun Yoshino, Samuel Klein, Christine M Kusminski, Philipp E Scherer
BACKGROUND & AIMS: We have previously reported that the mitochondrial dicarboxylate carrier (mDIC) is predominantly expressed in the white adipose tissue (WAT) and subject to regulation by metabolic cues. The specific physiological functions of mDIC and the reasons for its abundant presence in adipocytes are however poorly understood. METHODS: To systemically investigate the impact of mDIC function in adipocytes in vivo, we generated loss- and gain-of-function mouse models, selectively eliminating or overexpressing mDIC in mature adipocytes, respectively...
March 18, 2021: Journal of Hepatology
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