journal
https://read.qxmd.com/read/36933770/combination-immunotherapy-for-hepatocellular-carcinoma
#1
REVIEW
Lorenza Rimassa, Richard S Finn, Bruno Sangro
Single-agent immune checkpoint inhibitors (ICIs) have been tested in patients with advanced hepatocellular carcinoma (HCC) showing an objective response rate of 15-20%, mostly without a significant overall survival (OS) benefit. Furthermore, approximately 30% of HCC shows intrinsic resistance to ICIs. In the absence of predictive biomarkers to identify patients likely to benefit most from immunotherapy, research has moved to exploring combinations with potential activity in broader patient populations. Basket trials, including cohorts of patients with HCC, and early phase studies tested the combination of ICIs with antiangiogenic agents as well as the combination of two different ICIs...
March 16, 2023: Journal of Hepatology
https://read.qxmd.com/read/36922251/corrigendum-to-genome-wide-association-study-of-non-alcoholic-fatty-liver-and-steatohepatitis-in-a-histologically-characterised-cohort-%C3%A2-j-hepatol-2020-505-515
#2
Quentin M Anstee, Rebecca Darlay, Simon Cockell, Marica Meroni, Olivier Govaere, Dina Tiniakos, Alastair D Burt, Pierre Bedossa, Jeremy Palmer, Yang-Lin Liu, Guruprasad P Aithal, Michael Allison, Hannele Yki-Järvinen, Michele Vacca, Jean-Francois Dufour, Pietro Invernizzi, Daniele Prati, Mattias Ekstedt, Stergios Kechagias, Sven Francque, Salvatore Petta, Elisabetta Bugianesi, Karine Clement, Vlad Ratziu, Jörn M Schattenberg, Luca Valenti, Christopher P Day, Heather J Cordell, Ann K Daly
No abstract text is available yet for this article.
March 13, 2023: Journal of Hepatology
https://read.qxmd.com/read/36922250/corrigendum-to-ethyl-glucuronide-in-hair-detects-a-high-rate-of-harmful-alcohol-consumption-in-presumed-non-alcoholic-fatty-liver-disease-j-hepatol-77-2022-918-930
#3
Katharina Staufer, Ursula Huber-Schönauer, Georg Strebinger, Philipp Pimingstorfer, Silke Suesse, Thomas-Matthias Scherzer, Bernhard Paulweber, Peter Ferenci, Thomas Stimpfl, Michel Yegles, Christian Datz, Michael Trauner
No abstract text is available yet for this article.
March 13, 2023: Journal of Hepatology
https://read.qxmd.com/read/36913982/how-many-liver-transplantations-could-be-recovered-after-implementation-of-donation-after-cardiac-death-in-germany
#4
LETTER
Simon Moosburner, Igor M Sauer, Björn Weiß, Johann Pratschke, Nathanael Raschzok
No abstract text is available yet for this article.
March 11, 2023: Journal of Hepatology
https://read.qxmd.com/read/36907560/fgf19-fgfr4-mediated-elevation-of-etv4-facilitates-hepatocellular-carcinoma-metastasis-by-upregulating-pd-l1-and-ccl2
#5
EDITORIAL
Meng Xie, Zhuoying Lin, Xiaoyu Ji, Xiangyuan Luo, Zerui Zhang, Mengyu Sun, Xiaoping Chen, Bixiang Zhang, Huifang Liang, Danfei Liu, Yangyang Feng, Yijun Wang, Yiwei Li, Bifeng Liu, Wenjie Huang, Limin Xia
BACKGROUND & AIMS: Metastasis remains the major reason for high mortality of HCC patients. This study was designed to investigate the role of E-twenty-six-specific sequence variant 4 (ETV4) in promoting HCC metastasis and explored new combination therapy strategy for ETV4-mediated HCC metastasis. METHODS: PLC/PRF/5, MHCC97H, Hepa1-6 and H22 cells were used to establishment of orthotopic HCC Models. Clodronate liposomes were used to clear macrophages in C57BL/6 mice...
March 10, 2023: Journal of Hepatology
https://read.qxmd.com/read/36906109/myc-determines-lineage-commitment-in-kras-driven-primary-liver-cancer-development
#6
JOURNAL ARTICLE
Luana D'Artista, Athina Anastasia Moschopoulou, Iros Barozzi, Amanda J Craig, Marco Seehawer, Lea Herrmann, Martina Minnich, Tae-Won Kang, Elke Rist, Melanie Henning, Sabrina Klotz, Florian Heinzmann, Jule Harbig, Bence Sipos, Thomas Longerich, Martin Eilers, Daniel Dauch, Johannes Zuber, Xin Wei Wang, Lars Zender
BACKGROUND & AIMS: Primary liver cancer (PLC) comprises hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), two frequent and lethal tumor types that differ regarding their tumor biology and responses to cancer therapies. Liver cells harbor a high degree of cellular plasticity and can give rise to either HCC or iCCA, however, little is known about the cell intrinsic mechanisms directing an oncogenically transformed liver cell either to HCC or iCCA. The scope of this study was to identify cell intrinsic factors determining lineage commitment in PLC...
March 9, 2023: Journal of Hepatology
https://read.qxmd.com/read/36906108/the-present-evidence-summary-of-sars-cov-2-vaccine-associated-liver-injury-a-rapid-systematic-review
#7
LETTER
Zheng Li, Yue Hu, Yunlan Jiang
No abstract text is available yet for this article.
March 9, 2023: Journal of Hepatology
https://read.qxmd.com/read/36932007/an-infrequent-cause-of-spontaneous-liver-rupture
#8
Yiliam Fundora, Carla Fuster-Anglada, Clara Bassaganyas, David Toapanta, Octavi Bassegoda
No abstract text is available yet for this article.
March 8, 2023: Journal of Hepatology
https://read.qxmd.com/read/36898934/corrigendum-to-national-trends-in-retreatment-of-hcv-due-to-reinfection-or-treatment-failure-in-australia-j-hepatol-2023-260-270
#9
Joanne M Carson, Sebastiano Barbieri, Gail V Matthews, Gregory J Dore, Behzad Hajarizadeh
No abstract text is available yet for this article.
March 8, 2023: Journal of Hepatology
https://read.qxmd.com/read/36898503/platelet-defetcts-in-cirrhosis-fact-or-fiction
#10
LETTER
Francesco Violi, Pasquale Pignatelli, Vittoria Cammisotto
No abstract text is available yet for this article.
March 8, 2023: Journal of Hepatology
https://read.qxmd.com/read/36893854/role-of-immune-responses-for-development-of-nafld-associated-liver-cancer-and-prospects-for-therapeutic-modulation
#11
REVIEW
Neda Yahoo, Michael Dudek, Percy Knolle, Mathias Heikenwälder
The liver is the central metabolic organ of the body regulating energy and lipid metabolism and at the same time has potent immunological functions. Overwhelming the metabolic capacity of the liver by obesity and sedentary lifestyle leads to hepatic lipid accumulation, chronic necro-inflammation, enhanced mitochondrial/ER-stress and development of non-alcoholic fatty liver disease (NAFLD), with its pathologic form nonalcoholic steatohepatitis (NASH). Based on knowledge on pathophysiological mechanisms, specifically targeting metabolic diseases to prevent or slow down progression of NAFLD to liver cancer will become possible...
March 7, 2023: Journal of Hepatology
https://read.qxmd.com/read/36893853/deregulated-intracellular-pathways-define-novel-molecular-targets-for-hbv-specific-cd8-t-cell-reconstitution-in-chronic-hepatitis-b
#12
JOURNAL ARTICLE
Ilaria Montali, Camilla Ceccatelli Berti, Marco Morselli, Greta Acerbi, Valeria Barili, Giuseppe Pedrazzi, Barbara Montanini, Carolina Boni, Arianna Alfieri, Marco Pesci, Alessandro Loglio, Elisabetta Degasperi, Marta Borghi, Riccardo Perbellini, Amalia Penna, Diletta Laccabue, Marzia Rossi, Andrea Vecchi, Camilla Tiezzi, Valentina Reverberi, Chiara Boarini, Gianluca Abbati, Marco Massari, Pietro Lampertico, Gabriele Missale, Carlo Ferrari, Paola Fisicaro
BACKGROUND AND AIMS: In chronic HBV infection elevated ROS levels derived from dysfunctional mitochondria can cause increased protein oxidation and DNA damage in exhausted virus-specific CD8 T cells. Aim of this study was to understand how these defects are mechanistically interconnected in order to further elucidate T cell exhaustion pathogenesis and, doing so, to devise novel T cell-based therapies. METHODS: DNA damage and repair mechanisms, including parylation, CD38 expression and telomere length were studied in HBV-specific CD8 T cells from chronic HBV patients...
March 7, 2023: Journal of Hepatology
https://read.qxmd.com/read/36889360/the-exposome-and-liver-disease-how-environmental-factors-affect-liver-health
#13
REVIEW
Robert Barouki, Michel Samson, Etienne B Blanc, Massimo Colombo, Jessica Zucman-Rossi, Konstantinos N Lazaridis, Gary W Miller, Xavier Coumoul
Since the initial development of the exposome concept, much of the effort has been devoted to the characterization of the exposome through analytical, epidemiological, and toxicological/mechanistical studies. There is now an urgent need to link the exposome to human diseases and to include exposomics in the characterization of environment-linked pathologies together with genomics and other omics. Liver diseases are particularly well suited for such studies since major functions of this organ include the detection, detoxification, and elimination of xenobiotics as well as inflammatory responses...
March 6, 2023: Journal of Hepatology
https://read.qxmd.com/read/36889359/trem2-macrophages-suppress-cd8-t-cell-infiltration-after-transarterial-chemoembolization-in-hepatocellular-carcinoma
#14
JOURNAL ARTICLE
Jizhou Tan, Wenzhe Fan, Ting Liu, Bowen Zhu, Yafang Liu, Shutong Wang, Jian Wu, Jun Liu, Fan Zou, Jialiang Wei, Lingwei Liu, Xiaokai Zhang, Jialang Zhuang, Yi Wang, Haibiao Lin, Xianzhang Huang, Songling Chen, Ming Kuang, Jiaping Li
BACKGROUND & AIMS: The immune landscape of hepatocellular carcinoma (HCC) following transarterial chemoembolization (TACE) remains to be clarified. This study aimed to characterize the immune landscape following TACE and the underlying mechanism of HCC progression. METHODS: Tumor samples from 5 patients with treatment-naive HCC and 5 patients who received TACE therapy were collected and subjected to single-cell RNA sequencing. Another 22 paired samples were validated using immunofluorescence staining and flow cytometry...
March 6, 2023: Journal of Hepatology
https://read.qxmd.com/read/36870613/primary-sclerosing-cholangitis-and-overlap-features-of-autoimmune-hepatitis-a-coming-of-age-or-an-age-ist-problem
#15
REVIEW
Amanda Ricciuto, Binita M Kamath, Gideon M Hirschfield, Palak J Trivedi
Autoimmune liver diseases are siloed into three syndromes that define clinical practice. These classifiers can, and are, challenged by variant presentations across all ages, something inevitable to disease definitions that rely on interpreting inherently variable semi-quantitative/qualitative clinical, laboratory, pathological or radiological findings. Furthermore this remains premised by an ongoing absence of definable disease aetiologies. Clinicians thus encounter individuals with biochemical, serological, and histological manifestations that are common to both primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH), often labelled as 'PSC/AIH-overlap'...
March 2, 2023: Journal of Hepatology
https://read.qxmd.com/read/36870612/agile-scores-are-a-good-predictor-of-liver-related-events-in-patients-with-nafld
#16
LETTER
Takuma Nakatsuka, Ryosuke Tateishi, Masaya Sato, Mitsuhiro Fujishiro, Kazuhiko Koike
No abstract text is available yet for this article.
March 2, 2023: Journal of Hepatology
https://read.qxmd.com/read/36870611/interferon-induced-il-10-drives-systemic-t-cell-dysfunction-during-chronic-liver-injury
#17
JOURNAL ARTICLE
Carl-Philipp Hackstein, Jasper Spitzer, Konstantinos Symeonidis, Helena Horvatic, Tanja Bedke, Babett Steglich, Sabine Klein, Lisa M Assmus, Alexandru Odainic, Jennifer Szlapa, Nina Kessler, Marc Beyer, Ricarda Schmithausen, Eicke Latz, Richard A Flavell, Natalio Garbi, Christian Kurts, Beate M Kümmerer, Jonel Trebicka, Axel Roers, Samuel Huber, Susanne V Schmidt, Percy A Knolle, Zeinab Abdullah
BACKGROUND & AIMS: Patients with chronic liver disease (CLD) such as cirrhosis are at increased risk of intractable viral infections and are hyporesponsive to vaccination. Hallmarks of CLD and cirrhosis include microbial translocation and elevated levels of type I Interferon (IFN-I). We aimed to investigate the relevance of microbiota-induced IFN-I for the impaired adaptive immune responses in CLD. METHODS: We combined BDL and CCl4 models of liver injury with vaccination or LCMV-infection in transgenic mice lacking IFN-I in myeloid cells (LysM-Cre IFNARflox/flox ), IFNAR-induced IL-10 (MX1-Cre IL10flox/flox ) or IL-10R in T-cells (CD4-DN IL-10R)...
March 2, 2023: Journal of Hepatology
https://read.qxmd.com/read/36868481/liquid-biopsy-based-protein-biomarkers-for-risk-prediction-early-diagnosis-and-prognostication-of-cholangiocarcinoma
#18
JOURNAL ARTICLE
Ainhoa Lapitz, Mikel Azkargorta, Piotr Milkiewicz, Paula Olaizola, Ekaterina Zhuravleva, Marit M Grimsrud, Christoph Schramm, Ander Arbelaiz, Colm J O'Rourke, Adelaida La Casta, Malgorzata Milkiewicz, Tania Pastor, Mette Vesterhus, Raul Jimenez-Agüero, Michael T Dill, Angela Lamarca, Juan W Valle, Rocio I R Macias, Laura Izquierdo-Sanchez, Ylenia Pérez Castaño, Francisco Javier Caballero-Camino, Ioana Riaño, Marcin Krawczyk, Cesar Ibarra, Javier Bustamante, Luiz M Nova-Camacho, Juan M Falcon-Perez, Felix Elortza, Maria J Perugorria, Jesper B Andersen, Luis Bujanda, Tom H Karlsen, Trine Folseraas, Pedro M Rodrigues, Jesus M Banales
BACKGROUND & AIMS: Cholangiocarcinoma (CCA), heterogeneous biliary tumors with dismal prognosis, lacks accurate early diagnostic methods, especially important for individuals at high-risk (i.e., primary sclerosing cholangitis (PSC)). Here, we searched for protein biomarkers in serum extracellular vesicles (EVs). METHODS: EVs from patients with isolated PSC (n=45), concomitant PSC-CCA (n=44), PSC who developed CCA during follow-up (PSC to CCA; n=25), CCAs from non-PSC etiology (n=56), hepatocellular carcinoma (HCC; n=34) and healthy individuals (n=56) were characterized by mass-spectrometry...
March 1, 2023: Journal of Hepatology
https://read.qxmd.com/read/36868480/fluid-resuscitation-in-patients-with-cirrhosis-and-sepsis-a-multidisciplinary-perspective
#19
REVIEW
François Durand, John A Kellum, Mitra K Nadim
Fluid resuscitation is typically needed in patients with cirrhosis, sepsis and hypotension. However, the complex circulatory changes associated with cirrhosis with hyperdynamic state, increased splanchnic blood volume and relative central hypovolemia complicates fluid administration and monitoring of fluid status. In patients with advanced cirrhosis, larger volumes of fluids are needed to expand central blood volume and improve sepsis-induced organ hypoperfusion as compared to non-cirrhotic patients, at the cost of further increase in non-central blood volume...
March 1, 2023: Journal of Hepatology
https://read.qxmd.com/read/36858157/anticoagulation-improves-survival-in-patients-with-cirrhosis-and-portal-vein-thrombosis-the-importal-competing-risk-meta-analysis
#20
JOURNAL ARTICLE
Antonio Guerrero, Laura Del Campo, Fabio Piscaglia, Bernhard Scheiner, Guohong Han, Francesco Violi, Carlos-Noronha Ferreira, Luis Téllez, Thomas Reiberger, Stefania Basili, Javier Zamora, Agustín Albillos
BACKGROUND & AIMS: Previous meta-analyses demonstrated the safety and efficacy of anticoagulation in the recanalization of portal vein thrombosis in patients with cirrhosis. Whether this benefit translates into improved survival is unknown. We conducted an individual patient data (IPD) meta-analysis to assess the effect of anticoagulation on aal-cause mortality in cirrhosis with portal vein thrombosis. METHODS: In this IPD meta-analysis, we selected studies comparing anticoagulation vs...
February 27, 2023: Journal of Hepatology
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