journal
MENU ▼
Read by QxMD icon Read
search

Journal of Hepatology

journal
https://read.qxmd.com/read/31518646/a-cross-sectional-study-of-the-public-health-response-to-non-alcoholic-fatty-liver-disease-in-europe
#1
Jeffrey V Lazarus, Mattias Ekstedt, Giulio Marchesini, Jillian Mullen, Katja Novak, Juan M Pericàs, Elena Roel, Manuel Romero-Gómez, Vlad Ratziu, Frank Tacke, Helena Cortez-Pinto, Quentin M Anstee
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is a growing public health problem worldwide and has become an important field of biomedical inquiry. We aimed to determine whether European countries have mounted an adequate public health response to NAFLD and non-alcoholic steatohepatitis (NASH). METHODS: In 2018 and 2019, NAFLD experts in 29 European countries completed an English-language survey on policies, guidelines, awareness, monitoring, diagnosis and clinical assessment in their country...
September 10, 2019: Journal of Hepatology
https://read.qxmd.com/read/31515045/risk-stratification-in-primary-sclerosing-cholangitis-it-s-time-to-move-on-from-replicating-imperfection-and-break-the-glass-ceiling
#2
EDITORIAL
Palak J Trivedi
No abstract text is available yet for this article.
September 9, 2019: Journal of Hepatology
https://read.qxmd.com/read/31515044/the-six-and-twelve-score-for-tace-treatment-does-it-really-help-us
#3
LETTER
Marc Bourlière, Guillaume Pénaranda, Xavier Adhoute, Jean-Pierre Bronowicki
No abstract text is available yet for this article.
September 9, 2019: Journal of Hepatology
https://read.qxmd.com/read/31506188/treatment-of-infants-with-hepatitis-b-virus-a-window-of-opportunity
#4
EDITORIAL
Simon C Ling, Douglas Mogul
No abstract text is available yet for this article.
September 7, 2019: Journal of Hepatology
https://read.qxmd.com/read/31506187/reply-to-canadian-liver-transplant-allocation-for-hepatocellular-carcinoma
#5
LETTER
Christoph Tschuor, Christoph Kümmerli, Philipp Dutkowski, Roberto Hernandez-Alejandro, Pierre-Alain Clavien
No abstract text is available yet for this article.
September 7, 2019: Journal of Hepatology
https://read.qxmd.com/read/31500857/reply-to-magnetic-resonance-spectroscopy-a-surrogate-marker-of-hepatic-encephalopathy
#6
LETTER
Valérie A McLin, Olivier Braissant, Cristina Cudalbu
No abstract text is available yet for this article.
September 6, 2019: Journal of Hepatology
https://read.qxmd.com/read/31500856/magnetic-resonance-spectroscopy-a-surrogate-marker-of-hepatic-encephalopathy
#7
LETTER
Bertrand Hermann, Marika Rudler, Damien Galanaud, Dominique Thabut, Nicolas Weiss
No abstract text is available yet for this article.
September 6, 2019: Journal of Hepatology
https://read.qxmd.com/read/31500855/reply-to-the-six-and-twelve-score-for-tace-treatment-does-it-really-help-us
#8
LETTER
Qiuhe Wang, Dongdong Xia, Wei Bai, Enxin Wang, Guohong Han
No abstract text is available yet for this article.
September 6, 2019: Journal of Hepatology
https://read.qxmd.com/read/31499132/risk-of-hepatitis-b-surface-antigen-seroreversion-after-corticosteroid-in-patients-with-previous-hepatitis-b-virus-exposure
#9
Grace Lai-Hung Wong, Vincent Wai-Sun Wong, Becky Wing-Yan Yuen, Yee-Kit Tse, Terry Cheuk-Fung Yip, Hester Wing-Sum Luk, Grace Chung-Yan Lui, Henry Lik-Yuen Chan
BACKGROUND AND AIMS: Systemic corticosteroid may cause hepatitis B virus (HBV) reactivation, but the impact on patients with previous HBV exposure is poorly defined. We aimed to study the risk of hepatitis B surface antigen (HBsAg) seroreversion and hepatitis flare in patients with previous HBV exposure. METHODS: Patients who were negative for HBsAg and received corticosteroid in 2001-2010 were included. Patients who were positive for antibody to HBsAg (anti-HBs) and/or to hepatitis B core antigen (anti-HBc) was defined to have previous HBV exposure...
September 6, 2019: Journal of Hepatology
https://read.qxmd.com/read/31499131/development-of-a-nomogram-to-predict-outcome-after-liver-resection-for-hepatocellular-carcinoma-in-child-pugh-b-cirrhosis
#10
Giammauro Berardi, Zenichi Morise, Carlo Sposito, Kazuharu Igarashi, Valentina Panetta, Ilaria Simonelli, Sungho Kim, Brian K P Goh, Shoji Kubo, Shogo Tanaka, Yutaka Takeda, Giuseppe Maria Ettorre, Gregory C Wilson, Matteo Cimino, Chung-Yip Chan, Guido Torzilli, Tan To Cheung, Hironori Kaneko, Vincenzo Mazzaferro, David A Geller, Ho-Seong Han, Akishige Kanazawa, Go Wakabayashi, Roberto Ivan Troisi
BACKGROUND & AIMS: Treatment allocation of patients with hepatocellular carcinoma (HCC) on Child-Pugh B (CP-B) cirrhosis is controversial. Liver resection has been proposed by small series with acceptable outcomes, but data are limited. The aim of this study was to evaluate the outcomes of patients undergoing liver resection for HCC in CP-B cirrhosis focusing on the surgical risks and survivals. METHODS: Patients were retrospectively pooled from 14 international referral centers from 2002 to 2017...
September 6, 2019: Journal of Hepatology
https://read.qxmd.com/read/31499130/tnf-%C3%AE-ifn-%C3%AE-profile-of-hbv-specific-cd4-t-cells-is-associated-with-liver-damage-and-viral-clearance-in-chronic-hbv-infection
#11
Haoliang Wang, Heng Luo, Xing Wan, Xiaolan Fu, Qing Mao, Xiaomei Xiang, Yi Zhou, Weiwei He, Juan Zhang, Yanzhi Guo, Wenting Tan, Guohong Deng
BACKGROUND & AIMS: The role of Hepatitis B virus (HBV)-specific CD4 T cells in chronic HBV infection patients is not clear. METHODS: Through intracellular IFN-γ and TNF-α staining, HBV-specific CD4 T cells were analyzed in 68 chronic HBV infection patients with alanine aminotransferase (ALT) < 2×upper limit of normal (ULN) and 28 hepatitis B flare patients. HBV-specific HLA-DRB1*0803/HLA-DRB1*1202-restricted CD4 T-cell epitopes were identified. RESULTS: TNF-α producing cells were the dominant population in patients' HBV-specific CD4 T cells...
September 6, 2019: Journal of Hepatology
https://read.qxmd.com/read/31499129/il-17a-secreted-from-lymphatic-endothelial-cells-promotes-tumorigenesis-by-up-regulation-of-pd-l1-in-hepatoma-stem-cells
#12
Yuanyan Wei, Danfang Shi, Ziwei Liang, Yuming Liu, Yinan Li, Yang Xing, Weitao Liu, Zhilong Ai, Jianhui Zhuang, Xiaoning Chen, Qiang Gao, Jianhai Jiang
BACKGROUND & AIMS: Microenvironment regulates hepatoma stem cells behaviors. The contributions of lymphatic endothelial cells in hepatoma stem cells niche remain largely unknown. METHODS: The association between lymphatic endothelial cells and CD133+ hepatoma stem cells was analyzed using immunofluorescence and adhesion assays. The effects of the interaction between lymphatic endothelial cells and hepatoma stem cells on IL-17A expression were examined using western blot, qRT-PCR and luciferase reporter assay...
September 6, 2019: Journal of Hepatology
https://read.qxmd.com/read/31495534/canadian-liver-transplant-allocation-for-hepatocellular-carcinoma
#13
LETTER
Mayur Brahmania, Vladimir Marquez, Norman M Kneteman, Mamatha Bhat, Denis Marleau, Philip Wong, Kevork M Peletekian, Kelly W Burak, Stephen E Congly
No abstract text is available yet for this article.
September 5, 2019: Journal of Hepatology
https://read.qxmd.com/read/31493444/high-tolerance-of-hepatitis-b-virus-to-thermal-disinfection
#14
LETTER
Alexander König, Thoa Thi Than, Daniel Todt, Seung Kew Yoon, Jochen Steinmann, Eike Steinmann, Marc P Windisch
No abstract text is available yet for this article.
September 4, 2019: Journal of Hepatology
https://read.qxmd.com/read/31479696/ursodeoxycholic-acid-in-pregnancy
#15
REVIEW
Elsemieke de Vries, Ulrich Beuers
The case of a 34-year-old woman with primary biliary cholangitis (PBC) before, during and after pregnancy is described. The use of ursodeoxycholic acid during and after pregnancy is discussed. UDCA has not been approved by the drug regulatory authorities as a pregnancy-safe drug; therefore, reluctance of clinicians to prescribe UDCA during pregnancy is comprehendible. This Grand Round aims to provide a detailed analysis of the current evidence, safety data and clinical experience with ursodeoxycholic acid (and alternative drugs) during pregnancy and lactation...
August 31, 2019: Journal of Hepatology
https://read.qxmd.com/read/31470068/the-risk-of-incident-extrahepatic-cancers-is-higher-in-nonalcoholic-fatty-liver-disease-than-obesity-a-longitudinal-cohort-study
#16
Alina M Allen, Stephen B Hicks, Kristin C Mara, Joseph J Larson, Terry M Therneau
BACKGROUND: &Aims: Cancer is a major cause of death in nonalcoholic fatty liver disease (NAFLD). Obesity is a risk factor for cancers; however, the role of NAFLD in this association is unknown. We investigated the effect of NAFLD versus obesity on incident cancers. METHODS: We identified all incident cases of NAFLD in a US population between 1997-2016. Subjects with NAFLD were matched by age and sex to referent individuals from the same population (1:3) on the index diagnosis date...
August 27, 2019: Journal of Hepatology
https://read.qxmd.com/read/31470067/transient-elastography-for-screening-of-liver-fibrosis-cost-effectiveness-analysis-from-six-prospective-cohorts-in-europe-and-asia
#17
Miquel Serra-Burriel, Isabel Graupera, Pere Torán, Maja Thiele, Dominique Roulot, Vincent Wai-Sun Wong, Indra Neil Guha, Núria Fabrellas, Anita Arslanow, Carmen Expósito, Rosario Hernández, Grace Lai-Hung Wong, David Harman, Sarwa Darwish Murad, Aleksander Krag, Guillem Pera, Paolo Angeli, Peter Galle, Aithal Guruprasad, Llorenç Caballeria, Laurent Castera, Pere Ginès, Frank Lammert
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) pose an important challenge to current clinical healthcare pathways due to a large number of at-risk patients. Therefore, we aimed to explore the cost-effectiveness of transient elastography (TE) as a screening method to detect liver fibrosis in a primary care pathway. METHODS: Cost-effectiveness analysis using real-life individual patient data from six independent prospective cohorts (five from Europe and one from Asia)...
August 27, 2019: Journal of Hepatology
https://read.qxmd.com/read/31451285/allocation-of-deceased-donor-livers-is-there-a-most-appropriate-method
#18
EDITORIAL
James Neuberger, Julie K Heimbach
No abstract text is available yet for this article.
August 23, 2019: Journal of Hepatology
https://read.qxmd.com/read/31449860/management-of-adverse-events-with-tailored-sorafenib-dosing-prolongs-survival-of-hepatocellular-carcinoma-patients
#19
Francesco Tovoli, Luca Ielasi, Andrea Casadei-Gardini, Alessandro Granito, Francesco Giuseppe Foschi, Giulia Rovesti, Giulia Negrini, Giulia Orsi, Matteo Renzulli, Fabio Piscaglia
BACKGROUND &AIMS: Sorafenib is associated with multiple adverse events (AEs), potentially causing its permanent interruption. The impact of the physicians experience on the management of these AEs and the relative implications on clinical outcomes are unknown. We verified if the AEs management changed over time and if these modifications impacted on treatment duration and overall survival (OS). METHODS: We analysed the prospectively collected data of 338 consecutive patients who started sorafenib between January 2008 and December 2017 in three tertiary care centres in Italy...
August 23, 2019: Journal of Hepatology
https://read.qxmd.com/read/31449859/the-immunobiology-of-hepatocellular-carcinoma-in-humans-and-mice-basic-concepts-and-therapeutic-implications
#20
REVIEW
Jiajie Hou, Haiyan Zhang, Beicheng Sun, Michael Karin
Basic and clinical studies have demonstrated the efficacy of immunotherapy, a technical and conceptual breakthrough that has revolutionized cancer treatment. Hepatocellular carcinoma (HCC), a deadly malignancy with etiologic diversity and a chronic course, is strongly influenced by the immune system, and was recently found to partially benefit from immune checkpoint inhibitor therapy. Notably, HCC onco-immunology depends on diverse genetic and environmental factors that together shape cancer-promoting inflammation as well as immune dysfunction, critical processes that control HCC malignant progression and response to therapy...
August 23, 2019: Journal of Hepatology
journal
journal
20153
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"