journal

Journal of Hepatology

journal
https://read.qxmd.com/read/32649971/integrative-molecular-profiling-of-autoreactive-cd4-t-cells-in-autoimmune-hepatitis
#1
Amédée Renand, Iñaki Cervera-Marzal, Laurine Gil, Chuang Dong, Alexandra Garcia, Erwan Kervagoret, Hélène Auble, Sarah Habes, Caroline Chevalier, Fabienne Vavasseur, Béatrice Clémenceau, Anaïs Cardon, Jean-Paul Judor, Jean-François Mosnier, Florence Tanné, David-Axel Laplaud, Sophie Brouard, Jérôme Gournay, Pierre Milpied, Sophie Conchon
BACKGROUND & AIMS: In most autoimmune disorders, crosstalk of B cells and CD4 T cells results in the accumulation of autoantibodies. In autoimmune hepatitis (AIH), the presence of anti-Soluble Liver Antigen (SLA) autoantibodies is associated with reduced overall survival, but the associated autoreactive CD4 T cells have not been characterized yet. Here we isolated and deeply characterized SLA-specific CD4 T cells in AIH patients. METHODS: We used brief ex vivo re-stimulation with overlapping SLA peptides to isolate and phenotype circulating SLA-specific CD4 T cells, and integrative single-cell RNA-seq (scRNA-seq) to characterize their transcriptome and T cell receptor (TCR) repertoire...
July 7, 2020: Journal of Hepatology
https://read.qxmd.com/read/32649970/the-6-c-s-of-primary-sclerosing-cholangitis
#2
Maya Deeb, Tom H Karlsen, Gideon M Hirschfield
No abstract text is available yet for this article.
July 7, 2020: Journal of Hepatology
https://read.qxmd.com/read/32646619/reply-to-stereotactic-body-radiation-therapy-vs-radiofrequency-ablation-for-hcc-more-questions-than-answers
#3
LETTER
Nalee Kim, Jinsil Seong
No abstract text is available yet for this article.
July 6, 2020: Journal of Hepatology
https://read.qxmd.com/read/32634548/origin-hdv-genotype-and-persistent-viremia-determine-outcome-and-treatment-response-in-patients-with-chronic-hepatitis-delta
#4
Dominique Roulot, Ségolène Brichler, Richard Layese, Zahia BenAbdesselam, Fabien Zoulim, Vincent Thibault, Caroline Scholtes, Bruno Roche, Corinne Castelnau, Thierry Poynard, Olivier Chazouillères, Nathalie Ganne, Hélène Fontaine, Jerome Gournay, Dominique Guyader, Frédéric le Gal, Pierre Nahon, Françoise Roudot-Thoraval, Emmanuel Gordien
BACKGROUND/AIMS: Hepatitis delta virus (HDV) infection causes severe chronic liver disease in Hepatitis B virus (HBV) infected individuals. Factors associated with poor prognosis are largely unknown. METHODS: The French National Reference Centre for HDV performed a nationwide retrospective study on 1112 HDV-infected patients, collecting epidemiological, clinical, virological and histological data from the initial referral to the last recorded follow-up. RESULTS: 68...
July 4, 2020: Journal of Hepatology
https://read.qxmd.com/read/32634547/reply-to-liver-tests-abnormalities-in-covid-19-trick-or-treat
#5
LETTER
Qingxian Cai, Lin Xu, Jun Chen
No abstract text is available yet for this article.
July 4, 2020: Journal of Hepatology
https://read.qxmd.com/read/32624195/sofosbuvir-monotherapy-fails-to-achieve-hev-rna-elimination-in-patients-with-chronic-hepatitis-e-the-hepnet-sofe-pilot-study
#6
LETTER
Markus Cornberg, Sven Pischke, Tobias Müller, Patrick Behrendt, Felix Piecha, Julia Benckert, Daniel Todt, Eike Steinmann, Armin Papkalla, Maria von Karpowitz, Armin Koch, Ansgar Lohse, Svenja Hardtke, Michael P Manns, Heiner Wedemeyer
No abstract text is available yet for this article.
July 2, 2020: Journal of Hepatology
https://read.qxmd.com/read/32622664/toxicity-and-dosimetry-in-soramic-study
#7
LETTER
Margot Reinders, Arthur Braat, Marnix Lam
No abstract text is available yet for this article.
July 1, 2020: Journal of Hepatology
https://read.qxmd.com/read/32645361/inflammasome-activation-and-pyroptosis-in-lymphopenic-covid-19-liver-patients
#8
LETTER
Alexander Kroemer, Khalid Khan, Matthew Plassmeyer, Oral Alpan, M A Haseeb, Raavi Gupta, Thomas M Fishbein
No abstract text is available yet for this article.
June 29, 2020: Journal of Hepatology
https://read.qxmd.com/read/32615276/personalized-surveillance-for-hepatocellular-carcinoma-in-cirrhosis-using-machine-learning-adapted-to-hcv-status
#9
Etienne Audureau, Fabrice Carrat, Richard Layese, Carole Cagnot, Tarik Asselah, Dominique Guyader, Dominique Larrey, Victor De Lédinghen, Denis Ouzan, Fabien Zoulim, Dominique Roulot, Albert Tran, Jean-Pierre Bronowicki, Jean-Pierre Zarski, Ghassan Riachi, Paul Calès, Jean-Marie Péron, Laurent Alric, Marc Bourlière, Philippe Mathurin, Jean-Frédéric Blanc, Armand Abergel, Olivier Chazouillères, Ariane Mallat, Jean-Didier Grangé, Pierre Attali, Louis d'Alteroche, Claire Wartelle, Thông Dao, Dominique Thabut, Christophe Pilette, Christine Silvain, Christos Christidis, Eric Nguyen-Khac, Brigitte Bernard-Chabert, David Zucman, Vincent Di Martino, Angela Sutton, Stanislas Pol, Pierre Nahon, Pierre Nahon, Patrick Marcellin, Dominique Guyader, Stanislas Pol, Hélène Fontaine, Dominique Larrey, Victor De Lédinghen, Denis Ouzan, Fabien Zoulim, Dominique Roulot, Albert Tran, Jean-Pierre Bronowicki, Jean-Pierre Zarski, Vincent Leroy, Ghassan Riachi, Paul Calès, Jean-Marie Péron, Laurent Alric, Marc Bourlière, Philippe Mathurin, Sebastien Dharancy, Jean-Frédéric Blanc, Armand Abergel, Olivier Chazouillères, Ariane Mallat, Jean-Didier Grangé, Pierre Attali, Louis d'Alteroche, Claire Wartelle, Thông Dao, Dominique Thabut, Christophe Pilette, Christine Silvain, Christos Christidis, Eric Nguyen-Khac, Brigitte Bernard-Chabert, David Zucman, Vincent Di Martino
BACKGROUND AND AIMS: To develop algorithms based on machine learning predictive approaches to refine individualized predictions of hepatocellular carcinoma (HCC) risk according to HCV eradication in patients with cirrhosis included in the French ANRS CO12 CirVir cohort. METHODS: Patients with compensated biopsy-proven HCV-cirrhosis were included in 35 centers and followed a semi-annual HCC surveillance program. Three prognostic models for HCC occurrence were built, using (1) Fine-Gray regression as a benchmark, (2) single decision tree (DT), and (3) random survival forest for competing risks survival (RSF)...
June 29, 2020: Journal of Hepatology
https://read.qxmd.com/read/32610115/suboptimal-reliability-of-liver-biopsy-evaluation-has-implications-for-randomized-clinical-trials
#10
Beth A Davison, Stephen A Harrison, Gad Cotter, Naim Alkhouri, Arun Sanyal, Christopher Edwards, Jerry R Colca, Julie Iwashita, Gary G Koch, Howard C Dittrich
BACKGROUND & AIMS: Liver biopsies are a critical component of pivotal studies in nonalcoholic steatohepatitis (NASH) constituting main inclusion criteria, risk stratification factors and endpoints. We evaluated the reliability of NASH Clinical Research Network scoring of liver biopsies in a NASH clinical trial. METHODS: Digitized slides from 678 biopsies for 339 patients with paired biopsies randomized into the EMMINENCE study examining a novel insulin sensitizer (MSDC-0602K) in NASH were read independently by three hepatopathologists blinded to treatment code and scored using the NASH CRN Histological Scoring System...
June 28, 2020: Journal of Hepatology
https://read.qxmd.com/read/32610114/dampened-veph1-activates-mtorc1-signaling-by-weakening-the-tsc1-tsc2-association-in-hepatocellular-carcinoma
#11
Pingping Dong, Xiaoxiao Wang, Longzi Liu, Wenqing Tang, Lijie Ma, Wenjiao Zeng, Shaoyang Sun, Li Zhang, Ningping Zhang, Xizhong Shen, Harry L A Janssen, Ling Dong, Si Zhang, She Chen
BACKGROUND & AIMS: Abnormal activation of mTORC1 signaling occurs at high frequency in hepatocellular carcinoma (HCC). However, the underlying mechanisms remain elusive. In this study, we identified ventricular zone expressed pleckstrin homology domain-containing 1 (VEPH1) as a novel tumor suppressor via mTORC1 axis. METHODS: We performed qRT-PCR (92 pairs), western blot (30 pairs), and immunostaining (225 cases) assays in HCC tissue samples to evaluate VEPH1 expression...
June 28, 2020: Journal of Hepatology
https://read.qxmd.com/read/32605877/corrigendum-to-impaired-endothelial-autophagy-promotes-liver-fibrosis-by-aggravating-the-oxidative-stress-response-during-acute-liver-injury-j-hepatol-2019-458-469
#12
Maria Ruart, Laia Chavarria, Genís Campreciós, Nuria Suárez-Herrera, Carla Montironi, Sergi Guixé-Muntet, Jaume Bosch, Scott L Friedman, Juan Carlos Garcia-Pagán, Virginia Hernández-Gea
No abstract text is available yet for this article.
June 27, 2020: Journal of Hepatology
https://read.qxmd.com/read/32600827/autoimmune-hepatitis-possible-triggers-potential-treatments
#13
Johannes Herkel, Antonella Carambia, Ansgar W Lohse
No abstract text is available yet for this article.
June 26, 2020: Journal of Hepatology
https://read.qxmd.com/read/32598967/reduced-mitochondrial-resilience-enables-non-canonical-induction-of-apoptosis-after-tnf-receptor-signaling-in-virus-infected-hepatocytes
#14
Sandra Lampl, Marianne K Janas, Sainitin Donakonda, Marcus Brugger, Kerstin Lohr, Annika Schneider, Katrin Manske, Laura E Sperl, Jennifer Wettmarshausen, Constanze Müller, Melanie Laschinger, Daniel Hartmann, Norber Hüser, Fabiana Perrochi, Philippe Schmitt-Kopplin, Franz Hagn, Lars Zender, Veit Hornung, Christoph Borner, Andreas Pichlmair, Hamid Kashkar, Martin Klingenspor, Marco Prinz, Sabrina Schreiner, Marcus Conrad, Philipp J Jost, Hans Zischka, Katja Steiger, Martin Krönke, Dietmar Zehn, Ulrike Protzer, Mathias Heikenwälder, Percy A Knolle, Dirk Wohlleber
BACKGROUND & AIMS: Selective elimination of virus-infected hepatocytes occurs through virus-specific CD8 T-cells recognizing peptide-loaded MHC molecules. Here, we report that virus-infected hepatocytes are also selectively eliminated through a cell-autonomous mechanism. METHODS: We generated recombinant adenoviruses and genetically modified mouse models to identify the molecular mechanisms determining TNF-induced hepatocyte apoptosis in vivo and used in vivo bioluminescence imaging, immunohistochemistry, immunoblot analysis, RNAseq/proteome /phosphoproteome analyses, bioinformatic analyses, mitochondrial function tests...
June 26, 2020: Journal of Hepatology
https://read.qxmd.com/read/32589896/sars-cov-2-infection-in-liver-author-s-reply
#15
LETTER
Yijin Wang, Fengmin Lu, Jingmin Zhao
No abstract text is available yet for this article.
June 23, 2020: Journal of Hepatology
https://read.qxmd.com/read/32586641/intrahepatocytic-necroptosis-is-dispensable-for-hepatocyte-death-in-murine-immune-mediated-hepatitis
#16
LETTER
Annaïg Hamon, Claire Piquet-Pellorce, Marie-Thérèse Dimanche-Boitrel, Michel Samson, Jacques Le Seyec
No abstract text is available yet for this article.
June 23, 2020: Journal of Hepatology
https://read.qxmd.com/read/32585161/hepatocellular-type-ii-fibrinogen-inclusions-in-a-patient-with-severe-covid-19-and-hepatitis
#17
LETTER
Montserrat Fraga, Darius Moradpour, Florent Artru, Elodie Romailler, Jonathan Tschopp, Antoine Schneider, Haithem Chtioui, Marguerite Neerman-Arbez, Alessandro Casini, Lorenzo Alberio, Christine Sempoux
No abstract text is available yet for this article.
June 22, 2020: Journal of Hepatology
https://read.qxmd.com/read/32585160/advances-in-functional-and-molecular-mri-technologies-in-chronic-liver-diseases
#18
REVIEW
Iris Y Zhou, Onofrio A Catalano, Peter Caravan
MRI has emerged as the most comprehensive noninvasive diagnostic tool for liver diseases. In recent years, the value of MRI in the liver has been significantly enhanced by a wide range of contrast agents, both clinically available and under development, that add functional information to the anatomically detailed morphological images, or increase the distinction between normal and pathological tissues by targeting molecular and cellular events. Several classes of contrast agents are available for contrast-enhanced hepatic MRI, including 1) conventional nonspecific extracellular fluid (ECF) contrast agents for assessing tissue perfusion; 2) hepatobiliary-specific contrast agents that are taken up by functioning hepatocytes and excreted through the biliary system for evaluating hepatobiliary function; 3) Superparamagnetic iron oxide particles that accumulate in Kuppfer cells; and 4) novel molecular contrast agents that are biochemically targeted to specific molecular/cellular processes for staging liver diseases or detecting treatment responses...
June 22, 2020: Journal of Hepatology
https://read.qxmd.com/read/32580876/reply-to-transition-of-aki-to-ckd-in-cirrhosis-effect-of-baseline-egfr-and-unanswered-questions
#19
LETTER
Octavi Bassegoda, Elsa Solà, Pere Ginès
No abstract text is available yet for this article.
June 21, 2020: Journal of Hepatology
https://read.qxmd.com/read/32576471/udca-prophylaxis-for-post-transplant-pbc-recurrence-prevention-time-to-change-practice
#20
EDITORIAL
Jessica K Dyson, David E J Jones
No abstract text is available yet for this article.
June 20, 2020: Journal of Hepatology
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