journal
https://read.qxmd.com/read/37741346/bioactive-signaling-lipids-as-drivers-of-chronic-liver-diseases
#1
REVIEW
Eleanna Kaffe, Annamaria Tisi, Christiana Magkrioti, Vassilis Aidinis, Wajahat Z Mehal, Richard A Flavell, Mauro Maccarrone
Lipids are important components for multiple cellular functions, and most have structural or energy storage roles. However, a small fraction of lipids exerts bioactive roles through binding to G protein coupled receptors (GPCRs) and induce a plethora of functions including cell proliferation, differentiation, growth, migration, apoptosis, senescence and survival. Bioactive signaling lipids are potent modulators of metabolism and energy homeostasis, inflammation, tissue repair and malignant transformation. All these events are involved in the initiation and progression of chronic liver diseases...
September 21, 2023: Journal of Hepatology
https://read.qxmd.com/read/37735011/corrigendum-to-easl-clinical-practice-guidelines-on-sclerosing-cholangitis-j-hepatol-77-761-806
#2
(no author information available yet)
No abstract text is available yet for this article.
September 19, 2023: Journal of Hepatology
https://read.qxmd.com/read/37734684/are-we-ready-to-translate-metabolomics-into-clinical-practice-for-aclf-prediction-and-diagnosis
#3
EDITORIAL
Bryan D Badal, I Jane Cox, Jasmohan S Bajaj
No abstract text is available yet for this article.
September 19, 2023: Journal of Hepatology
https://read.qxmd.com/read/37734683/page-b-incorporating-moderate-hbv-dna-levels-predicts-risk-of-hcc-among-patients-entering-into-hbeag-positive-chronic-hepatitis-b
#4
JOURNAL ARTICLE
Ho Soo Chun, George V Papatheodoridis, Minjong Lee, Hye Ah Lee, Yeong Hwa Kim, Seo Hyun Kim, Yun-Seo Oh, Su Jin Park, Jihye Kim, Han Ah Lee, Hwi Young Kim, Tae Hun Kim, Eileen L Yoon, Dae Won Jun, Sang Hoon Ahn, Vana Sypsa, Cihan Yurdaydin, Pietro Lampertico, Jose Luis Calleja, Harry LA Janssen, George N Dalekos, John Goulis, Thomas Berg, Maria Buti, Seung Up Kim, Yoon Jun Kim
BACKGROUND & AIMS: Recent studies reported that moderate hepatitis B virus (HBV) DNA levels are significantly associated with hepatocellular carcinoma (HCC) risk in hepatitis B e antigen (HBeAg)-positive, non-cirrhotic patients with chronic hepatitis B (CHB). We aimed at developing and validating a new risk score to predict HCC development using baseline moderate HBV DNA levels in patients entering into HBeAg-positive CHB from chronic infection. METHODS: This multicenter cohort study recruited 3,585 HBeAg-positive, non-cirrhotic patients who started antiviral treatment with entecavir or tenofovir disoproxil fumarate at phase change into CHB from chronic infection in twenty-three tertiary university-affiliated hospitals of South Korea (2012-2020)...
September 19, 2023: Journal of Hepatology
https://read.qxmd.com/read/37730125/endoscopic-procedures-in-hepatology-current-trends-and-new-developments
#5
REVIEW
Wim Laleman, Emma Vanderschueren, Zain Seyad Mehdi, Reiner Wiest, Andres Cardenas, Jonel Trebicka
Gastrointestinal endoscopy has always formed a reliable and indispensable backbone in the diagnosis and management of hepatobilary disorders and their complications. However, with evolving non-invasive testing, personalized medicine has reframed the utility and necessity of endoscopical screening. Conversely, the growing interest and use of endoscopic ultrasound and advanced endoscopy within gastrointestinal units has also opened novel diagnostic and therapeutic avenues for patients with various hepatobiliary diseases...
September 18, 2023: Journal of Hepatology
https://read.qxmd.com/read/37730124/endocrine-aspects-of-metabolic-dysfunction-associated-steatotic-liver-disease-masld-beyond-insulin-resistance
#6
REVIEW
Alan L Hutchison, Federica Tavaglione, Stefano Romeo, Michael Charlton
While the links between metabolic dysfunction associated steatotic liver disease liver disease (MASLD) and obesity, insulin resistance are widely appreciated, there are a host of complex interactions between the liver and other endocrine axes. While it can be difficult to definitively distinguish direct causal relationships and those attributable to increased adipocyte mass, there is substantial evidence of direct and indirect specific endocrine dysregulation and severity of MASLD. Strong evidence of direct and indirect effects exists for low levels of growth hormone, sex hormones, and thyroid hormone with development and severity of disease...
September 18, 2023: Journal of Hepatology
https://read.qxmd.com/read/37726183/corrigendum-to-easl-clinical-practice-guidelines-on-the-management-of-cystic-liver-diseases-j-hepatol-77-1083-1108
#7
(no author information available yet)
No abstract text is available yet for this article.
September 17, 2023: Journal of Hepatology
https://read.qxmd.com/read/37722533/cyclosporine-vs-tacrolimus-after-liver-transplantation-for-primary-sclerosing-cholangitis-a-propensity-score-matched-intention-to-treat-analysis
#8
JOURNAL ARTICLE
Fredrik Åberg, Ville Sallinen, Samuli Tuominen, René Adam, Vincent Karam, Darius Mirza, Michael A Heneghan, Pål-Dag Line, William Bennet, Bo-Göran Ericzon, Michal Grat, Peter Lodge, Allan Rasmussen, Moritz Schmelzle, Douglas Thorburn, Constantino Fondevila, Ilkka Helanterä, Arno Nordin
BACKGROUND & AIMS: There is controversy regarding the optimal calcineurin inhibitor type after liver transplantation (LT) in primary sclerosing cholangitis (PSC). We compared tacrolimus with cyclosporine in a propensity score-matched intention-to-treat analysis based on registries representing nearly all LTs in Europe and the US. METHODS: From the European Liver Transplant Registry (ELTR) and Scientific Registry of Transplant Recipients (SRTR), we included adult patients with PSC and primary LT between 2000-2020...
September 16, 2023: Journal of Hepatology
https://read.qxmd.com/read/37717602/metabolic-dysfunction-associated-steatotic-liver-disease-where-does-non-alcoholic-fatty-liver-disease-in-liver-transplant-recipients-fit-in-this-new-definition
#9
LETTER
Narendra Singh Choudhary, Swapnil Dhampalwar, Neeraj Saraf, Arvinder S Soin
No abstract text is available yet for this article.
September 15, 2023: Journal of Hepatology
https://read.qxmd.com/read/37717601/metabolic-dysfunction-associated-steatotic-liver-disease-and-all-cause-cause-specific-mortality-among-adults-in-the-united-states
#10
LETTER
Donghee Kim, Karn Wijarnpreecha, George Cholankeril, Aijaz Ahmed
No abstract text is available yet for this article.
September 15, 2023: Journal of Hepatology
https://read.qxmd.com/read/37717600/nutrients-associated-with-metabolic-dysfunction-associated-steatotic-liver-disease
#11
LETTER
Seogsong Jeong
No abstract text is available yet for this article.
September 15, 2023: Journal of Hepatology
https://read.qxmd.com/read/37717599/in-situ-or-ex-situ-split-does-it-all-come-down-to-static-cold-storage
#12
LETTER
Xavier Muller, Guillaume Rossignol, Natacha Boulanger, Kayvan Mohkam, Jean-Yves Mabrut
No abstract text is available yet for this article.
September 15, 2023: Journal of Hepatology
https://read.qxmd.com/read/37716373/further-comments-on-the-changing-role-of-donor-warm-ischemia-time-in-dcd-liver-selection-in-the-era-of-machine-perfusion
#13
LETTER
Riccardo De Carlis, Andrea Lauterio, Davide Bernasconi, Burcin Taner
No abstract text is available yet for this article.
September 14, 2023: Journal of Hepatology
https://read.qxmd.com/read/37714382/authors-reply-early-neurological-worsening-in-wilson-s-disease-the-need-for-an-evidence-based-definition
#14
LETTER
Isabelle Mohr, Aurélia Poujois, Aftab Ala, Karl Heinz Weiss
No abstract text is available yet for this article.
September 13, 2023: Journal of Hepatology
https://read.qxmd.com/read/37714381/clinical-and-histological-features-under-different-nomenclatures-of-fatty-liver-disease-nafld-mafld-masld-and-metald
#15
LETTER
Lin Chen, Xuemei Tao, Minghui Zeng, Yuqiang Mi, Liang Xu
No abstract text is available yet for this article.
September 13, 2023: Journal of Hepatology
https://read.qxmd.com/read/37689322/immunosuppressive-cd10-alpl-neutrophils-promote-resistance-to-anti-pd-1-therapy-in-hcc-%C3%A2-by-mediating-irreversible-exhaustion-of-t-cells
#16
JOURNAL ARTICLE
Yan Meng, Fei Ye, Pingping Nie, Qiudong Zhao, Liwei An, Wenjia Wang, Shuping Qu, Zhemin Shen, Zhifa Cao, Xiaobing Zhang, Shi Jiao, Dong Wu, Zhaocai Zhou, Lixin Wei
BACKGROUND & AIMS: Remodeling the tumor microenvironment is a critical strategy for treating advanced hepatocellular carcinoma (HCC). Yet it remains poorly understood how distinct cell populations in the microenvironment mediate tumor resistance to immunotherapy such as anti-PD-1. METHODS: We analyzed the transcriptomic profiling at a single-cell resolution within tumor tissues from HCC patients scheduled to receive anti-PD-1-based immunotherapy. Our comparative analysis and experimental validation using flow cytometry and histopathological analysis uncovered a discrete subpopulation of cells associated with resistance to anti-PD-1 treatment in HCC patients and a rat model...
September 7, 2023: Journal of Hepatology
https://read.qxmd.com/read/37683735/afp-l3-and-dcp-strongly-predict-early-hepatocellular-carcinoma-recurrence-after-liver-transplantation
#17
JOURNAL ARTICLE
Joshua S Norman, P Jonathan Li, Prashant Kotwani, Amy M Shui, Francis Yao, Neil Mehta
BACKGROUND & AIMS: Alpha-fetoprotein (AFP) predicts hepatocellular carcinoma (HCC) recurrence after liver transplant (LT) but remains an imperfect biomarker. The role of DCP (des-gamma-carboxyprothrombin) and AFP-L3 (AFP bound to Lens culinaris agglutinin) in predicting HCC recurrence remains incompletely characterized. AFP-L3 and DCP could identify patients at high risk of post-transplant HCC recurrence and serve as liver transplant exclusion criteria to defer transplant until patients receive additional risk-reducing pre-transplant local regional therapy...
September 6, 2023: Journal of Hepatology
https://read.qxmd.com/read/37683734/nafld-to-masld-is-wokeism
#18
LETTER
Madhusudana Girija Sanal
No abstract text is available yet for this article.
September 6, 2023: Journal of Hepatology
https://read.qxmd.com/read/37678723/99-of-patients-with-nafld-meet-masld-criteria-and-natural-history-is-therefore-identical
#19
LETTER
Hannes Hagström, Johan Vessby, Mattias Ekstedt, Ying Shang
No abstract text is available yet for this article.
September 5, 2023: Journal of Hepatology
https://read.qxmd.com/read/37678722/hepatic-steatosis-aggravates-atherosclerosis-via-small-extracellular-vesicle-mediated-inhibition-of-cellular-cholesterol-efflux
#20
JOURNAL ARTICLE
Xu Chen, Shen Chen, Juan Pang, Rong Huang, Yiran You, Haoyang Zhang, Jinghe Xiao, Hongliang Xue, Wenhua Ling
BACKGROUND: &Aims: Non-alcoholic fatty liver disease (NAFLD) is now a growing chronic pandemic and associated with cardiovascular disease (CVD). However, how NAFLD affects the development and progression of CVD remains unclear and debatable. METHODS: Small extracellular vesicles (sEVs) from steatotic hepatocytes were isolated, characterized, and used to investigate the role and mechanisms of how hepatic steatosis promotes macrophage-derived foam cells formation and atherosclerosis (AS) progression...
September 5, 2023: Journal of Hepatology
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