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No abstract text is available yet for this article.
February 7, 2019: Journal of Hepatology
#2
REVIEW
Tim F Greten, Michal Mauda-Havakuk, Bernd Heinrich, Firouzeh Korangy, Bradford J Wood
Locoregional therapies are commonly used to treat patients with hepatocellular carcinoma. It has been noted for many years that locoregional therapies may have additional systemic effects other than simple tumor elimination. Immunological "side effects" have been described in response to locoregional therapies in animal studies and also in patients. With the advent of immunotherapy for hepatocellular carcinoma, there is an increasing interest in understanding how immunotherapy may be best combined with locoregional therapies...
February 6, 2019: Journal of Hepatology
#3
LETTER
Adam Morton
No abstract text is available yet for this article.
February 4, 2019: Journal of Hepatology
#4
LETTER
Filipe Andrade, Akash Shukla, Christophe Bureau, Marco Senzolo, Louis D'Alteroche, Alexandra Heurgué, Fanny Turon, Juan-Carlos Garcia-Pagan, Frédéric Oberti, Dhiraj Tripathi, Pierre-Emmanuel Rautou
No abstract text is available yet for this article.
February 4, 2019: Journal of Hepatology
#5
LETTER
Paolo Angeli, Mauro Bernardi
No abstract text is available yet for this article.
February 2, 2019: Journal of Hepatology
#6
LETTER
Andrea Lombardi, Valentina Zuccaro, Stefano Fagiuoli, Raffaele Bruno
No abstract text is available yet for this article.
February 1, 2019: Journal of Hepatology
#7
LETTER
Guido Beldi, Dominique Vuitton, Anja Lachenmayer, Bruno Heyd, Jean-François Dufour, Carine Richou, Daniel Candinas, Solange Bresson-Hadni
No abstract text is available yet for this article.
February 1, 2019: Journal of Hepatology
#8
LETTER
Katharina Borst, Theresa Graalmann, Ulrich Kalinke
No abstract text is available yet for this article.
January 31, 2019: Journal of Hepatology
#9
REVIEW
Manon Allaire, Pierre-Emmanuel Rautou, Patrice Codogno, Sophie Lotersztajn
Autophagy is a self-eating catabolic pathway that contributes to liver homeostasis through its role on energy balance and in the quality control of the cytoplasm, by removing misfolded proteins, damaged organelles and lipid droplets. Autophagy not only regulates hepatocyte functions but also impact on non-parenchymal cells such as endothelial cells, macrophages and hepatic stellate cells. Deregulation of autophagy has been linked to many liver diseases and its modulation is now recognized as a potential new therapeutic strategy...
January 31, 2019: Journal of Hepatology
#10
Eugenia Marbach-Breitrück, Madlen Matz-Soja, Ute Abraham, Wolfgang Schmidt-Heck, Susanne Sales, Christiane Rennert, Matthias Kern, Susanne Aleithe, Luise Spormann, Carlo Thiel, Raffaele Gerlini, Katrin Arnold, Nora Klöting, Reinhard Guthke, Damjana Rozman, Raffaele Teperino, Andrej Shevchenko, Achim Kramer, Rolf Gebhardt
BACKGROUND & AIMS: The mammalian circadian clock controls various aspects of liver metabolism and integrates nutritional signals. Recently, we described Hedgehog (Hh) signaling as a novel regulator of liver lipid metabolism. Here, we investigated crosstalk between hepatic Hh signaling and circadian rhythm. METHODS: Diurnal rhythms of Hh signaling were investigated in liver and hepatocytes from mice with ablation of Smoothened (SAC-KO) and crossbreeds with PER2::LUC reporter mice...
January 31, 2019: Journal of Hepatology
#11
LETTER
Elsa Solà, Cristina Solé, Pere Ginès
No abstract text is available yet for this article.
January 30, 2019: Journal of Hepatology
#12
Carlos Sanz-Garcia, Kyle L Poulsen, Damien Bellos, Han Wang, Megan R McMullen, Xiaoxia Li, Saurabh Chattopadhyay, Ganes Sen, Laura E Nagy
BACKGROUND & AIMS: Interferon regulatory factor 3 (IRF3) is a transcription factor mediating anti-viral responses, yet recent evidence indicates that IRF3 also has critical non-transcriptional functions, including activating RIG-I-like receptors-induced IRF-3-mediated pathway of apoptosis (RIPA) and restricting activity of NFκB. Using a novel murine model expressing only non-transcriptional IRF3 activity (Irf3S1/S1 ), we tested the hypothesis that non-transcriptional functions of IRF3 modulate innate immune responses in the Gao-binge (acute on chronic) model of alcohol-related liver disease...
January 30, 2019: Journal of Hepatology
#13
EDITORIAL
Gautam Mehta, Nick Sheron
No abstract text is available yet for this article.
January 28, 2019: Journal of Hepatology
#14
LETTER
Sonja M Kessler, Jessica Hoppstädter, Kevan Hosseini, Stephan Laggai, Johannes Haybaeck, Alexandra K Kiemer
No abstract text is available yet for this article.
January 24, 2019: Journal of Hepatology
#15
Guillaume Lassailly, Mohamed Bou Saleh, Natascha Leleu-Chavain, Massih Ningarhari, Emilie Gantier, Rodolphe Carpentier, Florent Artru, Viviane Gnemmi, Benjamin Bertin, Patrice Maboudou, Didier Betbeder, Céline Gheeraert, François Maggiotto, Sébastien Dharancy, Philippe Mathurin, Alexandre Louvet, Laurent Dubuquoy
OBJECTIVE: In liver transplantation, organ shortage leads to use marginal grafts that are more susceptible to ischemia reperfusion (IR). We identified nucleotide-binding oligomerization domain 1 (NOD1) as an important modulator of polymorphonuclear (PMN)-induced liver injury such as in IR. Here we aimed at elucidating its role in the liver IR, especially on the endothelium and hepatocyte. DESIGN: NOD1 WT and KO mice were treated with NOD1 agonists and submitted to liver IR...
January 24, 2019: Journal of Hepatology
#16
LETTER
Alberto Ferrarese, Paolo Feltracco, Stefania Barbieri, Umberto Cillo, Patrizia Burra, Marco Senzolo
No abstract text is available yet for this article.
January 23, 2019: Journal of Hepatology
#17
LETTER
Schalk van der Merwe, Wim Laleman, Lies Langouche, Philippe Meersseman
No abstract text is available yet for this article.
January 23, 2019: Journal of Hepatology
#18
LETTER
Virendra Singh, Akash Singh, Ritesh Agarwal
No abstract text is available yet for this article.
January 23, 2019: Journal of Hepatology
#19
LETTER
Xiao Xiang, Yang Wang, Dun-Chang Mo, Si-Qi Wang, Xiao-Dong Xun, Shi-Hua Hu, Qian Cheng, Zhao Li, Ji-Ye Zhu
No abstract text is available yet for this article.
January 23, 2019: Journal of Hepatology
#20
Lorenzo Mulazzani, Vito Cantisani, Fabio Piscaglia
No abstract text is available yet for this article.
January 23, 2019: Journal of Hepatology
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