Ho Soo Chun, George V Papatheodoridis, Minjong Lee, Hye Ah Lee, Yeong Hwa Kim, Seo Hyun Kim, Yun-Seo Oh, Su Jin Park, Jihye Kim, Han Ah Lee, Hwi Young Kim, Tae Hun Kim, Eileen L Yoon, Dae Won Jun, Sang Hoon Ahn, Vana Sypsa, Cihan Yurdaydin, Pietro Lampertico, Jose Luis Calleja, Harry LA Janssen, George N Dalekos, John Goulis, Thomas Berg, Maria Buti, Seung Up Kim, Yoon Jun Kim
BACKGROUND & AIMS: Recent studies reported that moderate hepatitis B virus (HBV) DNA levels are significantly associated with hepatocellular carcinoma (HCC) risk in hepatitis B e antigen (HBeAg)-positive, non-cirrhotic patients with chronic hepatitis B (CHB). We aimed at developing and validating a new risk score to predict HCC development using baseline moderate HBV DNA levels in patients entering into HBeAg-positive CHB from chronic infection. METHODS: This multicenter cohort study recruited 3,585 HBeAg-positive, non-cirrhotic patients who started antiviral treatment with entecavir or tenofovir disoproxil fumarate at phase change into CHB from chronic infection in twenty-three tertiary university-affiliated hospitals of South Korea (2012-2020)...
September 19, 2023: Journal of Hepatology