journal
https://read.qxmd.com/read/38484916/letter-to-the-editor-the-mafld-and-masld-conundrum-is-it-reinvention-of-the-wheel
#1
LETTER
Mariana M Ramírez-Mejía, Mohammed Eslam, Nahum Méndez-Sánchez
No abstract text is available yet for this article.
March 12, 2024: Journal of Hepatology
https://read.qxmd.com/read/38484915/reply-to-irli-or-not-irli-that-is-the-question
#2
LETTER
Ciro Celsa, Giuseppe Cabibbo, David James Pinato
No abstract text is available yet for this article.
March 12, 2024: Journal of Hepatology
https://read.qxmd.com/read/38484914/expanding-the-dialogue-a-closer-look-at-aih-management-and-hcc-risk
#3
LETTER
Dan Shan
No abstract text is available yet for this article.
March 12, 2024: Journal of Hepatology
https://read.qxmd.com/read/38479614/prospective-validation-of-the-easl-management-algorithm-for-acute-kidney-injury-in-cirrhosis
#4
JOURNAL ARTICLE
Ann Thu Ma, Cristina Solé, Adrià Juanola, Laia Escudé, Laura Napoleone, Emma Avitabile, Martina Pérez-Guasch, Marta Carol, Enrico Pompili, Jordi Gratacós-Ginés, Anna Soria, Ana Belén Rubio, Marta Cervera, Maria José Moreta, Manuel Morales, Elsa Solà, Esteban Poch, Núria Fabrellas, Isabel Graupera, Elisa Pose, Pere Ginès
BACKGROUND AND AIMS: The management of acute kidney injury (AKI) in cirrhosis is challenging. The EASL guidelines proposed an algorithm, but this has never been validated. We aimed to prospectively evaluate this algorithm in clinical practice. METHODS: Prospective cohort study of consecutive hospitalized patients with cirrhosis and AKI. EASL management algorithm includes identification/treatment of precipitating factors, 2-day albumin infusion in patients with AKI ≥ stage 1B, and treatment with terlipressin in patients with hepatorenal syndrome (HRS-AKI)...
March 11, 2024: Journal of Hepatology
https://read.qxmd.com/read/38479613/one-year-transplant-free-survival-following-hospital-discharge-after-icu-admission-for-aclf-in-the-netherlands
#5
JOURNAL ARTICLE
Jubi de Haan, Fabian Termorshuizen, Nicolette de Keizer, Diederik Gommers, Caroline den Hoed
BACKGROUND & AIMS: Patients with acute decompensated (AD) liver cirrhosis or acute-on-chronic liver failure (ACLF) often require intensive care unit (ICU) admission for organ support. Existing research, mostly from specialized liver transplant centers, largely addresses short-term outcomes. Our aim was to evaluate in-hospital mortality and 1-year transplant-free survival after hospital discharge in the Netherlands. METHODS: We conducted a nationwide observational cohort study, including patients with an history of cirrhosis or first complications of cirrhotic portal hypertension admitted to ICUs in the Netherlands between 2012 and 2020...
March 11, 2024: Journal of Hepatology
https://read.qxmd.com/read/38479612/validation-of-baveno-vii-criteria-and-other-non-invasive-diagnostic-algorithms-for-clinically-significant-portal-hypertension-in-hepatitis-delta
#6
JOURNAL ARTICLE
Mathias Jachs, Lisa Sandmann, Lukas Hartl, Tammo Tergast, Michael Schwarz, David Josef Maria Bauer, Lorenz Balcar, Alena Ehrenbauer, Benedikt Silvester Hofer, Markus Cornberg, Henrike Lenzen, Katja Deterding, Michael Trauner, Mattias Mandorfer, Heiner Wedemeyer, Thomas Reiberger, Benjamin Maasoumy
BACKGROUND AND AIMS: Non-invasive tests (NIT) for clinically significant portal hypertension (CSPH) in compensated advanced chronic liver disease (cACLD) lack validation in patients infected with hepatitis D virus (HDV). METHODS: HDV-cACLD patients (LSM ≥10 kPa or histological METAVIR F3/F4 fibrosis) who underwent paired HVPG and NIT assessment at Medical University of Vienna or Hannover Medical School between 2013 and 2023 were retrospectively included...
March 11, 2024: Journal of Hepatology
https://read.qxmd.com/read/38467379/efficacy-of-stereotactic-ablative-radiotherapy-in-patients-with-oligometastatic-hepatocellular-carcinoma-a-phase-ii-study
#7
JOURNAL ARTICLE
Seo Hee Choi, Byung Min Lee, Jina Kim, Do Young Kim, Jinsil Seong
BACKGROUND & AIMS: Stereotactic ablative radiotherapy (SABR) has demonstrated curative potential with survival benefits in patients with oligometastatic disease (OMD). However, limited evidence exists regarding its use in oligometastatic hepatocellular carcinoma (HCC). We aimed to prospectively investigate the efficacy and safety of SABR in patients with oligometastatic HCC. METHODS: We enrolled patients with controlled primary HCC and one to five metastatic lesions amenable to SABR...
March 9, 2024: Journal of Hepatology
https://read.qxmd.com/read/38462133/democratising-the-scientific-method
#8
LETTER
Shivaram Prasad Singh, Prajna Anirvan
No abstract text is available yet for this article.
March 8, 2024: Journal of Hepatology
https://read.qxmd.com/read/38462132/ultrasensitive-hbsag-assays-not-yet-ready-for-primetime
#9
LETTER
Marc G Ghany, Maria Buti, Pietro Lampertico, Hannah M Lee
No abstract text is available yet for this article.
March 8, 2024: Journal of Hepatology
https://read.qxmd.com/read/38460794/van-gogh-like-2-is-essential-for-the-architectural-patterning-of-the-mammalian-biliary-tree
#10
JOURNAL ARTICLE
Michaela Raab, Ersi Christodoulou, Roopesh Krishnankutty, Andreea Gradinaru, Alexander Daniel Walker, Paula Olaizola, Nicholas Thomas Younger, Anabel Martinez Lyons, Edward Joseph Jarman, Konstantinos Gournopanos, Alexander von Kriegsheim, Scott Hamilton Waddell, Luke Boulter
BACKGROUND & AIMS: In the developing liver, bipotent epithelial progenitor cells known as hepatoblasts undergo lineage segregation to form the two major epithelial cell types, hepatocytes that constitute the bulk of the liver parenchyma and biliary epithelial cells (cholangiocytes) which comprise the bile duct, a complex tubular network which is critical for normal liver function. Notch and TGFβ signalling promote the formation of a sheet of biliary epithelial cells, the ductal plate that organises into discontinuous tubular structures...
March 7, 2024: Journal of Hepatology
https://read.qxmd.com/read/38460793/pkd1l1-deficiency-drives-biliary-atresia-through-ciliary-dysfunction-in-biliary-epithelial-cells
#11
JOURNAL ARTICLE
Yi Zou Lim, Min Zhu, Yunguan Wang, Tripti Sharma, Shannon Kelley, Estelle Oertling, Hao Zhu, Natasha Corbitt
BACKGROUND AND AIMS: Syndromic biliary atresia is a cholangiopathy characterized by fibro-obliterative changes in the extrahepatic bile duct (EHBD) and congenital malformations including laterality defects. The aetiology remains elusive and faithful animal models are lacking. Genetic syndromes provide important clues for underlying pathogenic mechanisms of disease. We investigated the role of the gene Pkd1l1 in syndromic biliary atresia pathophysiology. METHODS: Constitutive and conditional Pkd1l1 knockout mice were generated to explore genetic pathology as a cause of syndromic biliary atresia...
March 7, 2024: Journal of Hepatology
https://read.qxmd.com/read/38460792/cutting-edges-in-the-hepatitis-b-virus-genome-how-rna-splicing-is-involved-in-modulating-virus-ultrastructure-to-promote-infection
#12
EDITORIAL
Stefan Seitz, Ralf Bartenschlager
No abstract text is available yet for this article.
March 7, 2024: Journal of Hepatology
https://read.qxmd.com/read/38460791/endothelial-pofut1-controls-injury-induced-liver-fibrosis-by-repressing-fibrinogen-synthesis
#13
JOURNAL ARTICLE
Shan He, Yuru Luo, Wangge Ma, Xiaoke Wang, Chengrong Yan, Wenyang Hao, Yuan Fang, Hongyu Su, Baochang Lai, Junhui Liu, Ying Xiong, Ting Bai, Xiaoyong Ren, Enqi Liu, Hua Han, Yue Wu, Zuyi Yuan, Yidong Wang
BACKGROUND & AIMS: NOTCH signaling in liver sinusoidal endothelial cells (LSECs) regulates liver fibrosis, a pathological feature of chronic liver diseases. POFUT1 is an essential regulator of NOTCH signaling. Here, we investigated the role of LSECs-expressed POFUT1 in liver fibrosis. METHODS: Endothelial-specific Pofut1 knockout mice were generated and subjected to experimental liver fibrosis by chronic carbon tetrachloride exposure or by common bile duct ligation...
March 7, 2024: Journal of Hepatology
https://read.qxmd.com/read/38458323/uric-acid-in-pediatric-masld-definition-is-it-time-to-implement-diagnostic-criteria
#14
LETTER
Anna Di Sessa, Stefano Guarino, Giuseppina Rosaria Umano, Emanuele Miraglia Del Giudice, Pierluigi Marzuillo
No abstract text is available yet for this article.
March 6, 2024: Journal of Hepatology
https://read.qxmd.com/read/38458322/autoimmune-hepatitis-mycophenolate-mofetil-versus-azathioprine-as-first-line-therapy
#15
LETTER
Cem Şimşek, Staffan Wahlin, Cumali Efe
No abstract text is available yet for this article.
March 6, 2024: Journal of Hepatology
https://read.qxmd.com/read/38458321/rare-monogenic-causes-of-steatotic-liver-disease-masquerading-as-masld
#16
LETTER
Martijn Cgj Brouwers, David Cassiman
No abstract text is available yet for this article.
March 6, 2024: Journal of Hepatology
https://read.qxmd.com/read/38458320/the-synergism-of-public-health-policies-and-social-work-may-reduce-mortality-from-cancer-liver-disease-and-cardiovascular-disease
#17
LETTER
Shijie Guo, Jingqiang Zeng
No abstract text is available yet for this article.
March 6, 2024: Journal of Hepatology
https://read.qxmd.com/read/38458319/syngeneic-murine-models-with-distinct-immune-microenvironments-represent-subsets-of-human-intrahepatic-cholangiocarcinoma
#18
JOURNAL ARTICLE
Jennifer L Tomlinson, Binbin Li, Jingchun Yang, Emilien Loeuillard, Hannah E Stumpf, Hendrien Kuipers, Ryan Watkins, Danielle M Carlson, Jessica Willhite, Daniel R O'Brien, Rondell P Graham, Xin Chen, Rory L Smoot, Haidong Dong, Gregory J Gores, Sumera I Ilyas
BACKGROUND & AIMS: Cholangiocarcinoma (CCA) is a poorly immunogenic malignancy with limited survival. Syngeneic, immunocompetent mouse models of CCA are an essential tool to elucidate the tumor immune microenvironment (TIME), understand mechanisms of tumor immune evasion, and test novel immunotherapeutic strategies. The scope of this study was to develop and characterize immunocompetent CCA models with distinct genetic drivers, and correlate tumor genomics, immunobiology, and therapeutic response...
March 6, 2024: Journal of Hepatology
https://read.qxmd.com/read/38452873/familial-coaggregation-of-masld-and-liver-related-outcomes
#19
LETTER
Fahim Ebrahimi, Jonas F Ludvigsson
No abstract text is available yet for this article.
March 5, 2024: Journal of Hepatology
https://read.qxmd.com/read/38428644/using-liver-stiffness-to-predict-and-monitor-the-risk-of-decompensation-and-mortality-in-patients-with-alcohol-related-liver-disease
#20
JOURNAL ARTICLE
Katrine Holtz Thorhauge, Georg Semmler, Stine Johansen, Katrine Prier Lindvig, Maria Kjærgaard, Johanne Kragh Hansen, Nikolaj Torp, Camilla Dalby Hansen, Peter Andersen, Benedikt Silvester Hofer, Wenyi Gu, Mads Israelsen, Mattias Mandorfer, Thomas Reiberger, Jonel Trebicka, Maja Thiele, Aleksander Krag
BACKGROUND & AIMS: Liver stiffness measurements (LSM) are recommended for disease prognostication and monitoring. We evaluated if LSM, using transient elastography, and LSM changes predict decompensation and mortality in patients with alcohol-related liver disease (ALD). METHODS: Observational cohort study of compensated patients at risk of ALD from Denmark and Austria. We evaluated the risk of decompensation and all-cause mortality, stratified for compensated advanced chronic liver disease (cACLD: Baseline LSM ≥10 kPa) and LSM changes after a median of 2 years...
February 28, 2024: Journal of Hepatology
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