journal
https://read.qxmd.com/read/33465402/we-need-stronger-evidence-for-or-against-hepatocellular-carcinoma-surveillance
#1
REVIEW
Peter Jepsen, Joe West
Current guidelines from EASL recommend that most patients with cirrhosis are offered surveillance for hepatocellular carcinoma (HCC), but fewer than expected patients actually receive it. The recommendation is based on observational studies and simulations, not randomized trials. In this opinion piece we argue that a randomized trial of HCC surveillance vs. no surveillance is necessary and feasible, and we believe that clinician and patient participation in HCC surveillance would be better if it were based on trial results demonstrating its value...
January 16, 2021: Journal of Hepatology
https://read.qxmd.com/read/33460690/safety-and-efficacy-of-in-vitro-fertilisation-in-patients-with-chronic-liver-disease-and-liver-transplantation-recipients
#2
Mussarat N Rahim, Eleni Theocharidou, Katherine Gar Yen Lau, Refah Ahmed, Flevin Marattukalam, Lisa Long, Mary D Cannon, Michael A Heneghan
BACKGROUND: Chronic liver disease and liver transplantation (LT) can delay both timing and ability of women to conceive. With increased awareness and availability of in vitro fertilisation (IVF), the need for accurate counselling is paramount. To date, minimal data exists to inform outcomes of IVF in patients with chronic liver disease, cirrhosis or post-LT. We report the largest experience of IVF in women with liver related subfertility (LRSF). METHODS: A retrospective analysis was performed on 42 women with LRSF who had undergone 57 IVF cycles between 1990-2019...
January 15, 2021: Journal of Hepatology
https://read.qxmd.com/read/33453331/yet-more-evidence-that-mafld-is-more-than-name-change
#3
LETTER
Mohammed Eslam, Vlad Ratziu, Jacob George
No abstract text is available yet for this article.
January 13, 2021: Journal of Hepatology
https://read.qxmd.com/read/33453330/mafld-a-holistic-view-to-redefining-fatty-liver-disease
#4
LETTER
Mohammed Eslam, Jacob George
No abstract text is available yet for this article.
January 13, 2021: Journal of Hepatology
https://read.qxmd.com/read/33453329/detecting-hcv-infection-by-means-of-mass-population-sars-cov-2-screening-a-pilot-experience-in-northern-italy
#5
LETTER
Andrea Giacomelli, Gabriele Pagani, Federico Conti, Cinzia Bassoli, Massimo Galli
No abstract text is available yet for this article.
January 13, 2021: Journal of Hepatology
https://read.qxmd.com/read/33453328/predicting-survival-after-liver-transplantation-in-patients-with-hepatocellular-carcinoma-using-the-lites-hcc-score
#6
David Goldberg, Alejandro Mantero, Craig Newcomb, Cindy Delgado, Kimberly A Forde, David E Kaplan, Binu John, Nadine Nuchovich, Barbara Dominguez, Ezekiel Emanuel, Peter P Reese
BACKGROUND & AIMS: Liver transplant priority in the US and Europe follows the 'sickest-first 'principle. However, for patients with hepatocellular carcinoma (HCC), priority is based on binary tumor criteria (e.g., Milan) to expedite transplant for patients with 'acceptable' post-transplant outcomes. Newer risk scores developed to overcome limitations of these binary criteria (e.g., Metroticket, HALT-HCC) are insufficient to be used for waitlist priority as they focus solely on HCC-related pre-transplant variables...
January 13, 2021: Journal of Hepatology
https://read.qxmd.com/read/33453327/mafld-a-game-changer-redefining-fatty-liver-disease-for-adults-and-children
#7
LETTER
Mohammed Eslam, Jacob George
No abstract text is available yet for this article.
January 13, 2021: Journal of Hepatology
https://read.qxmd.com/read/33453326/role-of-core-protein-mutations-in-the-development-of-occult-hbv-infection
#8
Jingna Chen, Bochao Liu, Xi Tang, Xin Zheng, Jinhui Lu, Ling Zhang, Wenjing Wang, Daniel Candotti, Yongshui Fu, Jean-Pierre Allain, Chengyao Li, Linhai Li, Tingting Li
BACKGROUND & AIMS: Occult hepatitis B virus (HBV) infection (OBI) is associated with transfusion-transmitted HBV infection and hepatocellular carcinoma. Studies on OBI genesis concentrated on mutations in the S region and the regulatory elements. The role of mutations in the core region of OBIs remains unclear. METHODS: Here, an OBI strain (SZA) carrying 9 amino acid (aa) substitutions in the core protein/capsid (Cp) was selected by sequence alignment and Western blot analysis from 26 genotype B OBI samples to extensively explore the impact of Cp mutations on viral antigen production in vitro and in vivo...
January 13, 2021: Journal of Hepatology
https://read.qxmd.com/read/33453325/reply-to-external-validation-of-amap-risk-score-in-chronic-hepatitis-c-genotype-4-patients-with-liver-cirrhosis-who-achieved-svr-following-daas
#9
LETTER
Rong Fan, Xueru Yin, Jinlin Hou
No abstract text is available yet for this article.
January 13, 2021: Journal of Hepatology
https://read.qxmd.com/read/33422337/il-2-leaves-its-mark-in-cirrhosis
#10
EDITORIAL
Alice R Burton, Laura J Pallett
No abstract text is available yet for this article.
January 6, 2021: Journal of Hepatology
https://read.qxmd.com/read/33386162/reply-to-underestimation-of-portal-pressures-by-wedge-hepatic-venous-pressures-in-patients-with-non-alcoholic-steatohepatitis-related-cirrhosis-possibilities-and-implications
#11
LETTER
José Ferrusquía-Acosta, Laura Turco, Virginia Hernández-Gea
No abstract text is available yet for this article.
December 29, 2020: Journal of Hepatology
https://read.qxmd.com/read/33359898/-the-predictive-value-of-significant-fibrosis-for-metabolic-disturbances-in-nafld-patients
#12
LETTER
Javier Ampuero, Rocío Gallego-Durán, Manuel Romero-Gómez
No abstract text is available yet for this article.
December 24, 2020: Journal of Hepatology
https://read.qxmd.com/read/33358254/underestimation-of-portal-pressures-by-wedge-hepatic-venous-pressures-in-patients-with-non-alcoholic-steatohepatitis-related-cirrhosis-possibilities-and-implications
#13
LETTER
Sanchit Sharma, Abhinav Anand, Anoop Saraya
No abstract text is available yet for this article.
December 22, 2020: Journal of Hepatology
https://read.qxmd.com/read/33358780/impact-of-the-covid-19-pandemic-on-hcv-elimination-in-spain
#14
LETTER
Maria Buti, Raquel Domínguez-Hernández, Miguel Angel Casado
No abstract text is available yet for this article.
December 20, 2020: Journal of Hepatology
https://read.qxmd.com/read/33353742/reply-to-prospective-validation-of-baveno-vi-criteria-in-virally-supressed-hbv-cirrhosis-more-evidence-is-needed
#15
LETTER
Haiyu Wang, Jinjun Chen
No abstract text is available yet for this article.
December 19, 2020: Journal of Hepatology
https://read.qxmd.com/read/33353741/prospective-validation-of-baveno-vi-criteria-in-virally-supressed-hbv-cirrhosis-more-evidence-is-needed
#16
LETTER
Sanchit Sharma, Samagra Agarwal
No abstract text is available yet for this article.
December 19, 2020: Journal of Hepatology
https://read.qxmd.com/read/33347953/clinical-utility-of-the-mafld-definition
#17
LETTER
Kenneth I Zheng, Dan-Qin Sun, Yi Jin, Pei-Wu Zhu, Ming-Hua Zheng
No abstract text is available yet for this article.
December 18, 2020: Journal of Hepatology
https://read.qxmd.com/read/33347952/association-of-liver-abnormalities-with-in-hospital-mortality-in-patients-with-covid-19
#18
Ze-Yang Ding, Gan-Xun Li, Lin Chen, Chang Shu, Jia Song, Wei Wang, Yu-Wei Wang, Qian Chen, Guan-Nan Jin, Tong-Tong Liu, Jun-Nan Liang, Peng Zhu, Wei Zhu, Yong Li, Bin-Hao Zhang, Huan Feng, Wan-Guang Zhang, Zhen-Yu Yin, Wen-Kui Yu, Yang Yang, Hua-Qiu Zhang, Zhou-Ping Tang, Hui Wang, Jun-Bo Hu, Ji-Hong Liu, Ping Yin, Xiao-Ping Chen, Bixiang Zhang
BACKGROUND AND AIMS: The evolution and clinical significance of abnormal liver chemistries and the impact of hepatitis B infection on outcome in patients with COVID-19 is not well characterized. This study aimed to explore these issues. METHODS: This large retrospective cohort study included 2073 patients with COVID-19 having definite outcomes in Wuhan, China. Longitudinal liver function tests were conducted and determined their associated factors and death risk by multivariate regression analyses...
December 18, 2020: Journal of Hepatology
https://read.qxmd.com/read/33347951/t-cell-receptor-repertoires-within-liver-allografts-are-different-to-those-in-the-peripheral-blood
#19
Young-Seon Mederacke, Mikalai Nienen, Michael Jarek, Robert Geffers, Katharina Hupa-Breier, Nina Babel, Petra Reinke, Ingmar Mederacke, Florian Wolfgang Rudolf Vondran, Danny Jonigk, Heiner Wedemeyer, Elmar Jaeckel
BACKGROUND AND AIMS: T cells are the main mediators of allogeneic immune responses. Specific T cell clones can be tracked by their unique T cell receptor (TCR), but specificity and function remain elusive and have not been investigated in human liver biopsies thus far. METHODS: TCR repertoire analysis of CD4+ , CD8+ and regulatory T cells of the peripheral blood and liver graft was performed in seven liver transplant recipients with either stable course (non-rejector, NR), subclinical cellular rejection (SCR) or acute cellular rejection (ACR) during an observation period from pre-transplant to six years post-transplant...
December 18, 2020: Journal of Hepatology
https://read.qxmd.com/read/33347950/response-to-the-systemic-inflammation-hypothesis-towards-a-new-paradigm-of-acute-decompensation-and-multiorgan-failure-in-cirrhosis
#20
LETTER
Ton Lisman, James P Luyendyk
No abstract text is available yet for this article.
December 18, 2020: Journal of Hepatology
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