journal
https://read.qxmd.com/read/38797397/identifying-predictors-of-acute-and-non-acute-decompensation-in-a-cohort-of-masld-predominant-cirrhosis
#1
LETTER
Akash Roy, Awanish Tewari, Nikhil Sonthalia, Uday Chand Ghoshal, Mahesh K Goenka
No abstract text is available yet for this article.
May 24, 2024: Journal of Hepatology
https://read.qxmd.com/read/38797396/enhancing-hepatitis-b-management-the-role-of-political-economic-and-educational-considerations-in-addressing-global-disparities
#2
LETTER
Yuxin Zhang, Yu Zhou
No abstract text is available yet for this article.
May 24, 2024: Journal of Hepatology
https://read.qxmd.com/read/38797395/reply-to-primary-hypobetalipoproteinemia-as-a-risk-factor-for-liver-complications
#3
LETTER
Matthieu Wargny, Bertrand Cariou
No abstract text is available yet for this article.
May 24, 2024: Journal of Hepatology
https://read.qxmd.com/read/38789012/the-transition-in-terminology-from-non-alcoholic-fatty-liver-disease-nafld-to-metabolic-dysfunction-associated-fatty-liver-disease-mafld-to-metabolic-associated-steatotic-liver-disease-masld
#4
LETTER
https://read.qxmd.com/read/38789011/agile-scores-in-masld-and-ald-external-validation-and-their-utility-in-clinical-algorithms
#5
JOURNAL ARTICLE
Margarita Papatheodoridi, Victor De Ledinghen, Monica Lupsor-Platon, Fabrizio Bronte, Jerome Boursier, Omar Elshaarawy, Fabio Marra, Maja Thiele, Georgios Markakis, Audrey Payance, Edgar Brodkin, Laurent Castera, George Papatheodoridis, Aleksander Krag, Umberto Arena, Sebastian Mueller, Paul Cales, Vincenza Calvaruso, Adele Delamarre, Massimo Pinzani, Emmanuel A Tsochatzis
BACKGROUND: Agile scores, including liver stiffness measurements (LSM) and routine clinical/laboratory biomarkers, have been developed for advanced fibrosis (F≥3) and cirrhosis, respectively, in patients with metabolic-associated steatotic liver disease (MASLD). We independently validated the diagnostic accuracy of these scores in MASLD, alcohol-related liver disease (ALD) and chronic hepatitis B or C (CHB/C) and assessed them in clinical algorithms with FIB-4 and LSM. METHODS: We included 4,243 patients (MASLD:912, ALD:386, CHB:597, CHC:2348) with LSM, liver biopsy and laboratory tests within 6 months...
May 22, 2024: Journal of Hepatology
https://read.qxmd.com/read/38789010/a-strategic-approach-three-tiered-management-for-enhancing-global-hepatitis-b-outcomes
#6
LETTER
Hui Li, Qin Guo, Chengshan Guo
No abstract text is available yet for this article.
May 22, 2024: Journal of Hepatology
https://read.qxmd.com/read/38782610/formation-and-transcriptional-regulation-of-hepatitis-b-virus-covalently-closed-circular-dna
#7
JOURNAL ARTICLE
Andoni Gomez-Moreno, Jinchao Guo, Heidi M Temple, Alexander Ploss
No abstract text is available yet for this article.
May 22, 2024: Journal of Hepatology
https://read.qxmd.com/read/38782120/myosteatosis-is-closely-associated-with-sarcopenia-and-significantly-worse-outcomes-in-patients-with-cirrhosis
#8
JOURNAL ARTICLE
Simone Di Cola, Gennaro D'Amico, Paolo Caraceni, Filippo Schepis, Simone Loredana, Pietro Lampertico, Pierluigi Toniutto, Silvia Martini, Sergio Maimone, Antonio Colecchia, Gianluca Svegliati Barone, Carlo Alessandria, Alessio Aghemo, Saveria Lory Crocè, Luigi Elio Adinolfi, Maria Rendina, Lucia Lapenna, Enrico Pompili, Giacomo Zaccherini, Dario Saltini, Massimo Iavarone, Giulia Tosetti, Carolina Martelletti, Veronica Nassisi, Alberto Ferrarese, Ilaria Giovo, Chiara Masetti, Nicola Pugliese, Michele Campigotto, Riccardo Nevola, Manuela Merli
BACKGROUND AND AIM: Sarcopenia and myosteatosis are common in patients with cirrhosis. This study aimed to determine the prevalence of these muscle changes, their interrelations and their prognostic impact over a 12-month period. METHODS: We conducted a prospective multicentre study involving 433 patients. Sarcopenia and myosteatosis were evaluated using computed tomography scans. The 1-year cumulative incidence of relevant events was assessed by competing risk analysis...
May 21, 2024: Journal of Hepatology
https://read.qxmd.com/read/38782119/helicases-ddx5-and-ddx17-promote-heterogeneity-in-hbv-transcription-termination-in-infected-human-hepatocytes
#9
JOURNAL ARTICLE
Fleur Chapus, Guillaume Giraud, Pélagie Huchon, Mélanie Rodà, Xavier Grand, Caroline Charre, Chloé Goldsmith, Armando Andres Roca Suarez, Maria-Guadalupe Martinez, Judith Fresquet, Audrey Diederichs, Maëlle Locatelli, Hélène Polvèche, Caroline Scholtès, Isabelle Chemin, Hector Hernandez Vargas, Michel Rivoire, Cyril F Bourgeois, Fabien Zoulim, Barbara Testoni
BACKGROUND & AIMS: Transcription termination fine tunes gene expression and contributes to specify the function of RNAs in eukaryotic cells. Transcription termination of hepatitis B virus (HBV) is subjected to the recognition of the canonical polyadenylation signal (cPAS) common to all viral transcripts. The regulation of the usage of this cPAS and its impact on viral gene expression and replication is currently unknown. APPROACH & RESULTS: To unravel the regulation of HBV transcript termination, we implemented a 3' RACE-PCR assay coupled to single molecule sequencing both in in vitro infected hepatocytes and in chronically infected patients...
May 21, 2024: Journal of Hepatology
https://read.qxmd.com/read/38782118/a-multimodal-atlas-of-hepatocellular-carcinoma-reveals-convergent-evolutionary-paths-and-bad-apple-effect-on-clinical-trajectory
#10
JOURNAL ARTICLE
Jianbin Chen, Neslihan Arife Kaya, Ying Zhang, Raden Indah Kendarsari, Karthik Sekar, Shay Lee Chong, Veerabrahma Pratap Seshachalam, Wen Huan Ling, Cheryl Zi Jin Phua, Hannah Lai, Hechuan Yang, Bingxin Lu, Jia Qi Lim, Siming Ma, Sin Chi Chew, Khi Pin Chua, Jacob Josiah Santiago Alvarez, Lingyan Wu, London Ooi, Alexander Yaw-Fui Chung, Peng Chung Cheow, Juinn Huar Kam, Alfred Wei-Chieh Kow, Iyer Shridhar Ganpathi, Chairat Bunchaliew, Jidapa Thammasiri, Peng Soon Koh, Diana Bee-Lan Ong, Jasmine Lim, Vanessa H de Villa, Rouchelle D Dela Cruz, Tracy Jiezhen Loh, Wei Keat Wan, Wei Qiang Leow, Yi Yang, Jin Liu, Anders Jacobsen Skanderup, Yin Huei Pang, Gwyneth Shook Ting Soon, Krishnakumar Madhavan, Tony Kiat-Hon Lim, Glenn Bonney, Brian K P Goh, Valerie Chew, Yock Young Dan, Han Chong Toh, Roger Sik-Yin Foo, Wai Leong Tam, Weiwei Zhai, Pierce Kah-Hoe Chow
BACKGROUND & AIMS: Hepatocellular Carcinoma (HCC) is a highly fatal cancer characterized by high intra-tumor heterogeneity (ITH). A panoramic understanding of its tumor evolution, in relation to its clinical trajectory, may provide novel prognostic and treatment strategies. METHODS: Through the Asia-Pacific Hepatocellular Carcinoma (AHCC) trials group (NCT03267641), we recruited one of the largest prospective cohorts of HCC with over 600 whole genome and transcriptome samples from 123 treatment-naïve patients...
May 21, 2024: Journal of Hepatology
https://read.qxmd.com/read/38777260/transitioning-fib-4-score-from-fibrosis-screening-tool-to-key-biomarker-for-clinical-endpoints
#11
LETTER
David Petroff, Thomas Berg, Johannes Wiegand
No abstract text is available yet for this article.
May 20, 2024: Journal of Hepatology
https://read.qxmd.com/read/38777259/reply-incidence-and-predictors-of-hepatocellular-carcinoma-in-patients-with-autoimmune-hepatitis
#12
LETTER
Francesca Colapietro, Ana Lleo
No abstract text is available yet for this article.
May 20, 2024: Journal of Hepatology
https://read.qxmd.com/read/38772794/erratum-to-easl-clinical-practice-guidelines-on-acute-on-chronic-liver-failure-j-hepatol-79-2023-461-491
#13
(no author information available yet)
No abstract text is available yet for this article.
May 20, 2024: Journal of Hepatology
https://read.qxmd.com/read/38763844/in-memoriam-valeer-desmet-1931-2024
#14
JOURNAL ARTICLE
Tania Roskams, Johan Fevery
No abstract text is available yet for this article.
May 18, 2024: Journal of Hepatology
https://read.qxmd.com/read/38763358/angiocrine-signaling-in-sinusoidal-homeostasis-and-liver-diseases
#15
REVIEW
Jinhang Gao, Tian Lan, Enis Kostallari, Yangkun Guo, Enjiang Lai, Adrien Guillot, Bisen Ding, Frank Tacke, Chengwei Tang, Vijay H Shah
The hepatic sinusoids are composed of liver sinusoidal endothelial cells (LSEC), which are surrounded by hepatic stellate cells (HSC) and contain liver-resident macrophages called Kupffer cells, and other patrolling immune cells. All these cells communicate with each other and with hepatocytes to maintain sinusoidal homeostasis and a spectrum of hepatic functions under healthy conditions. Sinusoidal homeostasis is disrupted by metabolites, toxins, viruses, and other pathological factors, leading to liver injury, chronic liver diseases, and liver cirrhosis...
May 17, 2024: Journal of Hepatology
https://read.qxmd.com/read/38763357/long-term-use-of-tenofovir-disoproxil-fumarate-increases-fracture-risk-in-elderly-patients-with-chronic-hepatitis-b-reply-to-wu-et-al
#16
LETTER
Jimmy Che-To Lai, Terry Cheuk-Fung Yip, Grace Lai-Hung Wong
No abstract text is available yet for this article.
May 17, 2024: Journal of Hepatology
https://read.qxmd.com/read/38762170/a-turning-point-in-hepatology-easl-reflects-on-the-first-approved-drug-for-mash
#17
EDITORIAL
Sven Francque, Aleksander Krag, Debbie L Shawcross, Shira Zelber-Sagi
No abstract text is available yet for this article.
May 16, 2024: Journal of Hepatology
https://read.qxmd.com/read/38762169/increases-and-decreases-in-liver-stiffness-measurements-are-independently-associated-with-the-risk-of-liver-related-events-in-nafld
#18
JOURNAL ARTICLE
Samer Gawrieh, Eduardo Vilar-Gomez, Laura A Wilson, Francis Pike, David E Kleiner, Brent A Neuschwander-Tetri, Anna Mae Diehl, Srinivasan Dasarathy, Kris V Kowdley, Bilal Hameed, James Tonascia, Rohit Loomba, Arun J Sanyal, Naga Chalasani
BACKGROUND AND AIMS: The clinical significance of change in liver stiffness measurement (LSM) by vibration-controlled transient elastography (VCTE) in patients with NAFLD is not well-understood. We prospectively defined rates of progression to and regression from LSM-defined compensated advanced chronic liver disease (cACLD) and their associations with liver-related events (LRE). METHODS: Participants in the NASH Clinical Research Network NAFLD Database 2 and 3 studies were included...
May 16, 2024: Journal of Hepatology
https://read.qxmd.com/read/38762168/enhancing-the-understanding-of-the-risk-of-incident-fracture-in-entecavir-and-tdf-treated-elderly-patients-with-chronic-hepatitis-b-chb
#19
LETTER
ZuJun Wen
No abstract text is available yet for this article.
May 16, 2024: Journal of Hepatology
https://read.qxmd.com/read/38759891/reply-to-tailoring-allocation-policies-and-improving-access-to-pediatric-liver-transplantation-in-italy-outframing-and-concluding
#20
LETTER
Marco Spada, Roberta Angelico, Silvia Trapani, Lucia Masiero, Francesca Puoti, Michele Colledan, Davide Cintorino, Renato Romagnoli, Umberto Cillo, Massimo Cardillo
No abstract text is available yet for this article.
May 15, 2024: Journal of Hepatology
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