Journal of Hepatology

Current guidelines from EASL recommend that most patients with cirrhosis are offered surveillance for hepatocellular carcinoma (HCC), but fewer than expected patients actually receive it. The recommendation is based on observational studies and simulations, not randomized trials. In this opinion piece we argue that a randomized trial of HCC surveillance vs. no surveillance is necessary and feasible, and we believe that clinician and patient participation in HCC surveillance would be better if it were based on trial results demonstrating its value...

BACKGROUND: Chronic liver disease and liver transplantation (LT) can delay both timing and ability of women to conceive. With increased awareness and availability of in vitro fertilisation (IVF), the need for accurate counselling is paramount. To date, minimal data exists to inform outcomes of IVF in patients with chronic liver disease, cirrhosis or post-LT. We report the largest experience of IVF in women with liver related subfertility (LRSF). METHODS: A retrospective analysis was performed on 42 women with LRSF who had undergone 57 IVF cycles between 1990-2019...

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BACKGROUND & AIMS: Liver transplant priority in the US and Europe follows the 'sickest-first 'principle. However, for patients with hepatocellular carcinoma (HCC), priority is based on binary tumor criteria (e.g., Milan) to expedite transplant for patients with 'acceptable' post-transplant outcomes. Newer risk scores developed to overcome limitations of these binary criteria (e.g., Metroticket, HALT-HCC) are insufficient to be used for waitlist priority as they focus solely on HCC-related pre-transplant variables...

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BACKGROUND & AIMS: Occult hepatitis B virus (HBV) infection (OBI) is associated with transfusion-transmitted HBV infection and hepatocellular carcinoma. Studies on OBI genesis concentrated on mutations in the S region and the regulatory elements. The role of mutations in the core region of OBIs remains unclear. METHODS: Here, an OBI strain (SZA) carrying 9 amino acid (aa) substitutions in the core protein/capsid (Cp) was selected by sequence alignment and Western blot analysis from 26 genotype B OBI samples to extensively explore the impact of Cp mutations on viral antigen production in vitro and in vivo...

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BACKGROUND AND AIMS: The evolution and clinical significance of abnormal liver chemistries and the impact of hepatitis B infection on outcome in patients with COVID-19 is not well characterized. This study aimed to explore these issues. METHODS: This large retrospective cohort study included 2073 patients with COVID-19 having definite outcomes in Wuhan, China. Longitudinal liver function tests were conducted and determined their associated factors and death risk by multivariate regression analyses...

BACKGROUND AND AIMS: T cells are the main mediators of allogeneic immune responses. Specific T cell clones can be tracked by their unique T cell receptor (TCR), but specificity and function remain elusive and have not been investigated in human liver biopsies thus far. METHODS: TCR repertoire analysis of CD4+ , CD8+ and regulatory T cells of the peripheral blood and liver graft was performed in seven liver transplant recipients with either stable course (non-rejector, NR), subclinical cellular rejection (SCR) or acute cellular rejection (ACR) during an observation period from pre-transplant to six years post-transplant...

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