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Journal of Hepatology

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https://read.qxmd.com/read/31102719/new-sequential-combinations-of-noninvasive-fibrosis-tests-provide-an-accurate-diagnosis-of-advanced-fibrosis-in-nafld
#1
Jérôme Boursier, Maeva Guillaume, Vincent Leroy, Marie Irlès, Marine Roux, Adrien Lannes, Juliette Foucher, Floraine Zuberbuhler, Cyrielle Delabaudière, Justine Barthelon, Sophie Michalak, Jean-Baptiste Hiriart, Jean-Marie Peron, Theophile Gerster, Brigitte Le Bail, Jeremie Riou, Gilles Hunault, Wassil Merrouche, Frederic Oberti, Laurence Pelade, Isabelle Fouchard, Christophe Bureau, Paul Calès, Victor de Ledinghen
BACKGROUND & AIMS: Advanced liver fibrosis is an important diagnostic target in non-alcoholic fatty liver disease (NAFLD) as it defines the subgroup of patients with impaired prognosis. The non-invasive diagnosis of advanced fibrosis is currently limited by the suboptimal positive predictive value and the grey zone (representing indeterminate diagnosis) of fibrosis tests. The combination of fibrosis tests significantly improves the diagnosis of liver fibrosis in chronic hepatitis C...
May 15, 2019: Journal of Hepatology
https://read.qxmd.com/read/31102718/current-and-innovative-emerging-therapies-for-porphyrias-with-hepatic-involvement
#2
REVIEW
Antonio Fontanellas, Matías A Ávila, Karl E Anderson, Jean-Charles Deybach
Porphyrias are rare inherited disorders caused by specific enzyme dysfunctions in the heme synthesis pathway resulting in abnormal accumulation of specific pathway intermediates. The symptoms depend upon the chemical characteristics of these substances. Porphyrins are photoreactive and cause photocutaneous lesions on sunlight-exposed areas, whereas accumulation of porphyrin precursors is related to acute neurovisceral attacks. Current therapies are suboptimally effective, and mostly address symptoms rather than underlying disease mechanisms...
May 15, 2019: Journal of Hepatology
https://read.qxmd.com/read/31097204/role-of-hgf-for-reprogramming-human-liver-progenitor-cells-non-essential-but-stimulative-supplement
#3
LETTER
Yu Huang, Takayuki Miyoshi, Yusuke Sakai, Takanobu Hara, Wei-Li Gu, Susumu Eguchi
No abstract text is available yet for this article.
May 13, 2019: Journal of Hepatology
https://read.qxmd.com/read/31097203/reply-to-role-of-hgf-for-reprogramming-human-liver-progenitor-cells-non-essential-but-stimulative-supplement
#4
LETTER
Seung Bum Lee, Yohan Kim, Kyojin Kang, Valentina M Factor, Daekwan Seo, Ji-Hye Yim, Dongho Choi, Jaemin Jeong
No abstract text is available yet for this article.
May 13, 2019: Journal of Hepatology
https://read.qxmd.com/read/31096006/patient-reported-symptoms-during-and-after-direct-acting-antiviral-therapies-for-chronic-hepatitis-c-the-prop-up-study
#5
Donna M Evon, Souvik Sarkar, Jipcy Amador, Anna S Lok, Richard K Sterling, Paul W Stewart, Bryce B Reeve, Marina Serper, Nancy Reau, K Rajender Reddy, Adrian M Di Bisceglie, David R Nelson, Carol E Golin, Joseph K Lim, Michael W Fried
BACKGROUND & AIMS: A comprehensive analysis of changes in symptoms and functioning during and after direct acting antiviral (DAA) therapy for chronic hepatitis C virus (HCV) has not been conducted for patients treated in real-world clinical settings. We evaluated patient-reported outcomes (PROs) in a diverse cohort of HCV patients treated with commonly-prescribed DAAs. METHODS: PROP UP is a U.S. multicenter observational study of 1,601 HCV patients treated with DAAs in 2016-2017...
May 13, 2019: Journal of Hepatology
https://read.qxmd.com/read/31096005/sustained-virologic-response-to-direct-acting-antiviral-therapy-in-patients-with-chronic-hepatitis-c-and-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#6
Fanpu Ji, Yee Hui Yeo, Mike Tzuhen Wei, Eiichi Ogawa, Masaru Enomoto, Dong Hyun Lee, Etsuko Iio, John Lubel, Wenjun Wang, Bin Wei, Tatsuya Ide, Carmen Monica Preda, Fabio Conti, Tatsuya Minami, Rob Bielen, Hitomi Sezaki, Michele Barone, Philippe Kolly, Po-Sung Chu, Victor Virlogeux, Dennis Eurich, Linda Henry, Michelle B Bass, Takanori Kanai, Shuangsuo Dang, Zongfang Li, Jean-François Dufour, Fabien Zoulim, Pietro Andreone, Ramsey C Cheung, Yasuhito Tanaka, Norihiro Furusyo, Hidenori Toyoda, Akihiro Tamori, Mindie H Nguyen
BACKGROUND & AIMS: Questions remain about the effect of hepatocellular carcinoma (HCC) on response to interferon-free direct-acting antiviral (DAA) therapy for chronic hepatitis C (CHC) patients compared to those without HCC. Using a systematic review and meta-analysis approach, we aimed to investigate the effect of DAA therapy on sustained virologic response among CHC patients with active, inactive and no HCC. METHODS: PubMed, Embase, Web of Science, and the Cochrane Controlled Trials Register were searched from 1/1/2013 to 9/24/2018...
May 13, 2019: Journal of Hepatology
https://read.qxmd.com/read/31078544/declining-hepatitis-c-virus-related-liver-disease-burden-in-the-direct-acting-antiviral-therapy-era-in-new-south-wales-australia
#7
Maryam Alavi, Matthew G Law, Heather Valerio, Jason Grebely, Janaki Amin, Behzad Hajarizadeh, Christine Selvey, Jacob George, Gregory J Dore
BACKGROUND: Population-level evidence for the impact of direct-acting antiviral (DAA) therapy on hepatitis C virus (HCV)-related disease burden is lacking. We aimed to evaluate trends in HCV-related decompensated cirrhosis (DC) and hepatocellular carcinoma (HCC) hospitalisation, and liver-related and all-cause mortality in the pre-DAA (2001-2014) and DAA therapy (2015-2017) eras in New South Wales (NSW), Australia. METHODS: HCV notifications (1993-2016) were linked to hospital admissions (2001-2017) and mortality (1995-2017)...
May 9, 2019: Journal of Hepatology
https://read.qxmd.com/read/31077792/efficient-long-term-amplification-of-hepatitis-b-virus-isolates-after-infection-of-slow-proliferating-hepg2-ntcp-cells
#8
Alexander König, Jaewon Yang, Eunji Jo, Kyu Ho Paul Park, Hyun Kim, Thoa Thi Than, Xiyong Song, Xiaoxuan Qi, Xinghong Dai, Soonju Park, David Shum, Wang-Shick Ryu, Jung-Hee Kim, Seung Kew Yoon, Jun Yong Park, Sang Hoon Ahn, Kwang-Hyub Han, Wolfram Hubert Gerlich, Marc Peter Windisch
BACKGROUND & AIMS: Hepatitis B virus (HBV) spreads through the infected liver paralleled by secretion into the blood. HBV-susceptible in vitro infection models do not efficiently amplify viral progeny or support cell-to-cell spread. We sought to establish a cell culture system for the amplification of infectious HBV from clinical specimens. METHODS: Selection of an HBV-susceptible sodium-taurocholate cotransporting polypeptide-overexpressing HepG2 cell clone (HepG2-NTCPsec+) producing high titers of infectious progeny virus...
May 8, 2019: Journal of Hepatology
https://read.qxmd.com/read/31077791/fetal-origin-confers-radio-resistance-on-liver-macrophages-via-p21-cip1-waf1
#9
Radika Soysa, Sarah Lampert, Sebastian Yuen, Alyse N Douglass, Wanyu Li, Klaus Pfeffer, Ian N Crispe
BACKGROUND AND AIMS: Cells of hematopoietic origin, including macrophages, are generally radiation sensitive but a subset of Kupffer cells (KCs) is relatively radioresistant. Here we focused on the identity of the radioresistant KCs in unmanipulated mice and the mechanism of radioresistance. METHODS: We employed Emr1- and inducible CX3Cr1-based fate-mapping strategies combined with the RiboTag reporter to identify the total KCs and the embryo-derived KCs respectively...
May 8, 2019: Journal of Hepatology
https://read.qxmd.com/read/31075323/the-beneficial-effects-of-mediterranean-diet-over-low-fat-diet-may-be-mediated-by-decreasing-hepatic-fat-content
#10
Yftach Gepner, Ilan Shelef, Oded Komy, Noa Cohen, Dan Schwarzfuchs, Nitzan Bril, Michal Rein, Dana Serfaty, Shira Kenigsbuch, Hila Zelicha, Anat Yaskolka Meir, Lilac Tene, Avital Bilitzky, Gal Tsaban, Yoash Chassidim, Benjamin Sarusy, Uta Ceglarek, Joachim Thiery, Michael Stumvoll, Matthias Blüher, Meir Stampfer, Assaf Rudich, Iris Shai
BACKGROUND AND AIM: It is unclear if reduction in hepatic fat content (HFC) is a major mediator of the cardiometabolic benefit of lifestyle intervention, and whether it holds prognostic information beyond visceral adipose tissue (VAT) loss. In the present sub-study, we hypothesized that HFC loss in response to dietary interventions induces specific beneficial effects independent of VAT changes. METHODS: In an 18-month weight-loss trial, 278 participants with abdominal obesity/dyslipidemia were randomized to low-fat (LF) or Mediterranean/low-carbohydrate (MED/LC+28g walnuts/day) diets with/without moderate physical activity (PA)...
May 7, 2019: Journal of Hepatology
https://read.qxmd.com/read/31075322/convalescent-plasma-therapy-for-persistent-hepatitis-e-virus-infection
#11
LETTER
Michael Ankcorn, Jennifer Gallacher, Samreen Ijaz, Yusri Taha, Heli Harvala, Sheila Maclennan, Emma C Thomson, Chris Davis, Joshua B Singer, Ana da Silva Filipe, Katherine Smollett, Marc Niebel, Malcolm G Semple, Richard S Tedder, Stuart McPherson
No abstract text is available yet for this article.
May 7, 2019: Journal of Hepatology
https://read.qxmd.com/read/31100314/chronic-hepatitis-delta-virus-infection-leads-to-functional-impairment-and-severe-loss-of-mait-cells
#12
Joana Dias, Julia Hengst, Tiphaine Parrot, Edwin Leeansyah, Sebastian Lunemann, David F G Malone, Svenja Hardtke, Otto Strauss, Christine L Zimmer, Lena Berglin, Thomas Schirdewahn, Sandra Ciesek, Nicole Marquardt, Thomas von Hahn, Michael P Manns, Markus Cornberg, Hans-Gustaf Ljunggren, Heiner Wedemeyer, Johan K Sandberg, Niklas K Björkström
BACKGROUND & AIMS: Hepatitis delta virus (HDV) infection is the most severe form of viral hepatitis. Although HDV-associated liver disease is considered immune-mediated, adaptive immune responses against HDV are weak. Thus, the role of several other cell-mediated mechanisms such as those driven by mucosa-associated invariant T (MAIT) cells, a group of innate-like T cells being highly enriched in the human liver, have not been extensively studied in clinical HDV infection. METHODS: MAIT cells from a sizeable cohort of chronic HDV patients were analyzed ex vivo and in vitro after stimulation...
May 6, 2019: Journal of Hepatology
https://read.qxmd.com/read/31071368/activated-hepatic-stellate-cells-and-portal-fibroblasts-contribute-to-cholestatic-liver-fibrosis-in-mdr2-knockout-mice
#13
Takahiro Nishio, Ronglin Hu, Yukinori Koyama, Shuang Liang, Sara B Rosenthal, Gen Yamamoto, Daniel Karin, Jacopo Baglieri, Hsiao-Yen Ma, Jun Xu, Xiao Liu, Debanjan Dhar, Keiko Iwaisako, Kojiro Taura, David A Brenner, Tatiana Kisseleva
BACKGROUND AND AIMS: Chronic liver injury often results in activation of hepatic myofibroblasts and development of liver fibrosis. Hepatic myofibroblasts may originate from three major sources; Hepatic Stellate Cells (HSCs), Portal Fibroblasts (PFs), or fibrocytes. Their contribution to liver fibrosis varies dependent on the etiology of liver injury. Here we assessed the composition of hepatic myofibroblasts in multidrug resistance gene 2 knockout (Mdr2-/- ) mice, a genetic model that resembles primary sclerosing cholangitis in patients...
May 6, 2019: Journal of Hepatology
https://read.qxmd.com/read/31071367/outcomes-of-liver-transplantation-for-non-alcoholic-steatohepatitis-a-european-liver-transplant-registry-study
#14
Debashis Haldar, Barbara Kern, James Hodson, Matthew James Armstrong, Rene Adam, Gabriela Berlakovich, Josef Fritz, Benedikt Feurstein, Wolfgang Popp, Vincent Karam, Paolo Muiesan, John O'Grady, Neville Jamieson, Stephen J Wigmore, Jacques Pirenne, Seyed Ali Malek-Hosseini, Ernest Hidalgo, Yaman Tokat, Andreas Paul, Johann Pratschke, Michael Bartels, Pavel Trunecka, Utz Settmacher, Massimo Pinzani, Christophe Duvoux, Philip Noel Newsome, Stefan Schneeberger
BACKGROUND & AIMS: Little is known about outcomes of liver transplantation for patients with non-alcoholic steatohepatitis (NASH). We aimed to determine the frequency and outcomes of liver transplantation for patients with NASH in Europe and identify prognostic factors. METHODS: We analyzed data from patients transplanted for end-stage liver disease between January 2002 and December 2016 using the European Liver Transplant Registry database. We compared data between patients with NASH versus other etiologies...
May 6, 2019: Journal of Hepatology
https://read.qxmd.com/read/31071366/glycolytic-activation-of-peritumoral-monocytes-fosters-immune-privilege-via-pfkfb3-pd-l1-axis-in-human-hepatocellular-carcinoma
#15
Dong-Ping Chen, Wan-Ru Ning, Ze-Zhou Jiang, Zhi-Peng Peng, Ling-Yan Zhu, Shi-Mei Zhuang, Dong-Ming Kuang, Limin Zheng, Yan Wu
BACKGROUND: & Aims: PD-L1 expression on antigen-presenting cells (APCs) is essential for T cell impairment, and PD-L1-expressing macrophages may mechanistically shape and therapeutically predict the clinical efficacy of PD-L1/PD-1 blockade. Despite the clinical success fostered by immune checkpoint inhibitors, the mechanisms underlying PD-L1 upregulation in human tumor microenvironments remain an enigma. METHODS: Monocytes/macrophages were purified from peripheral blood, non-tumor, or paired tumor tissues of patients with hepatocellular carcinoma (HCC), and their possible glycolytic switch was evaluated...
May 6, 2019: Journal of Hepatology
https://read.qxmd.com/read/31060841/a-hydrodynamic-hypothesis-for-the-pathogenesis-of-glymphatic-system-impairment-in-hepatic-encephalopathy
#16
LETTER
Pasquale Gallina, Oreste Gallo, Claudio Nicoletti, Roberto Giulio Romanelli
No abstract text is available yet for this article.
May 3, 2019: Journal of Hepatology
https://read.qxmd.com/read/31056366/the-dawn-of-a-new-easl-a-new-chapter-in-the-history-of-the-european-association-for-the-study-of-the-liver
#17
EDITORIAL
Tom H Karlsen, Phil N Newsome
No abstract text is available yet for this article.
May 2, 2019: Journal of Hepatology
https://read.qxmd.com/read/31036351/mechanical-stimuli-control-liver-homeostasis
#18
EDITORIAL
Frédéric P Lemaigre
No abstract text is available yet for this article.
April 26, 2019: Journal of Hepatology
https://read.qxmd.com/read/31029380/reducing-mother-to-child-transmission-of-hcv-is-it-attainable-with-a-multidisciplinary-approach
#19
LETTER
Julie Hong, Tatyana Kushner, Douglas Dieterich, David Garry, Luis A Marcos, Christy Beneri, Rhoda Sperling, Pruthvi Patel
No abstract text is available yet for this article.
April 24, 2019: Journal of Hepatology
https://read.qxmd.com/read/31027993/combination-therapy-of-sofosbuvir-and-ribavirin-fails-to-clear-chronic-hepatitis-e-infection-in-a-multivisceral-transplanted-patient
#20
LETTER
Marten Schulz, C Patrick Papp, Claus-Thomas Bock, Jörg Hofmann, Undine A Gerlach, Max Magnus Maurer, Dennis Eurich, Tobias Mueller
No abstract text is available yet for this article.
April 23, 2019: Journal of Hepatology
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