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Journal of Heart and Lung Transplantation

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https://read.qxmd.com/read/30898555/short-term-results-with-transcatheter-aortic-valve-replacement-for-treatment-of-left-ventricular-assist-device-patients-with-symptomatic-aortic-insufficiency
#1
Amin Yehya, Vivek Rajagopal, Christopher Meduri, James Kauten, Morris Brown, Lynn Dean, Julie Webster, Arun Krishnamoorthy, Tara Hrobowski, David Dean
BACKGROUND: After 3years of continuous-flow left ventricular assist device (CF-LVAD) support, nearly a third of patients develop at least moderate aortic insufficiency (AI). Percutaneous occluder devices, surgical aortic valve replacement (SAVR), and urgent heart transplantation are available treatment options. Transcatheter aortic valve replacement (TAVR) has not been widely used for treating symptomatic AI in patients on LVAD support. METHODS: Retrospective chart review and data analysis from October 2010 through August 2017 was performed...
March 11, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30885530/primary-graft-dysfunction-worry-less-about-organ-quality-and-do-more-to-improve-candidate-condition
#2
EDITORIAL
Matthew L Stone, Melanie D Everitt
No abstract text is available yet for this article.
March 11, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30852097/dynamic-flow-responses-to-expiratory-maneuvers-in-left-ventricular-assist-device-patients
#3
LETTER
Pankaj Jain, Kavitha Muthiah, Sajad Shehab, Desiree Robson, Christopher S Hayward
No abstract text is available yet for this article.
February 27, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30852096/extended-criteria-donor-lungs-do-not-impact-recipient-outcomes-in-pediatric-transplantation
#4
Wiebke Sommer, Fabio Ius, Carsten Müller, Dmitry Bobylev, Christian Kuehn, Murat Avsar, Jawad Salman, Thierry Siemeni, Jane Miha O, Alexander Horke, Axel Haverich, Igor Tudorache, Nicolaus Schwerk, Gregor Warnecke
BACKGROUND: Pediatric lung transplantation remains the only curative treatment option for some end-stage lung diseases in childhood. Recipient numbers outnumber potential donor organs, and therefore a broader group of donor organs must be considered for pediatric lung transplantation. Herein we describe the outcome of utilizing extended criteria donor organs in pediatric lung transplantation. METHODS: A retrospective analysis was performed on all pediatric lung transplantations performed at the Hannover Medical School between April 2010 and December 2016...
February 27, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30850154/elevated-pre-transplant-left-ventricular-end-diastolic-pressure-increases-primary-graft-dysfunction-risk-in-double-lung-transplant-recipients
#5
David Li, Justin Weinkauf, Alim Hirji, Ali Kapasi, Dale Lien, Jayan Nagendran, Daniel Kim, Justin Ezekowitz, Kieran Halloran
BACKGROUND: Primary graft dysfunction (PGD) represents ischemia‒reperfusion injury in the lung allograft, and elevated left ventricular end-diastolic pressure (LVEDP) may contribute to capillary leak. We tested whether pre-transplant LVEDP or pulmonary capillary wedge pressure (mPCWP) are related to PGD risk. We hypothesized that elevated LVEDP and mPCWP would increase PGD risk. METHODS: We reviewed adult double lung transplant recipients at the University of Alberta Hospital from 2004 to 2016 with pre-transplant LVEDP measurements...
February 18, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30846234/prothrombotic-activity-of-cytokine-activated-endothelial-cells-and-shear-activated-platelets-in-the-setting-of-ventricular-assist-device-support
#6
Alice Apostoli, Valentina Bianchi, Nina Bono, Annalisa Dimasi, Kaitlyn R Ammann, Yana Roka Moiia, Andrea Montisci, Jawaad Sheriff, Danny Bluestein, Gianfranco B Fiore, Federico Pappalardo, Gabriele Candiani, Alberto Redaelli, Marvin J Slepian, Filippo Consolo
BACKGROUND: We systematically analyzed the synergistic effect of: (i) cytokine-mediated inflammatory activation of endothelial cells (ECs) with and (ii) shear-mediated platelet activation (SMPA) as a potential contributory mechanism to intraventricular thrombus formation in the setting of left ventricular assist device (LVAD) support. METHODS: Intact and shear-activated human platelets were exposed to non-activated and cytokine-activated ECs. To modulate the level of LVAD-related shear activation, platelets were exposed to shear stress patterns of varying magnitude (30, 50, and 70 dynes/cm2 , 10 minutes) via a hemodynamic shearing device...
February 18, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30846233/acid-sphingomyelinase-deficiency-niemann%C3%A2-pick-disease-type-b-as-an-inflammatory-disease
#7
LETTER
Olivier Lidove, Wladimir Mauhin, Jonathan London
No abstract text is available yet for this article.
February 16, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30824289/risk-of-anastomotic-dehiscence-in-patients-with-pulmonary-fibrosis-transplanted-while-receiving-anti-fibrotics-experience-of-the-australian-lung-transplant-collaborative
#8
John A Mackintosh, Maitri Munsif, Lucy Ranzenbacher, Claire Thomson, Michael Musk, Gregory Snell, Allan Glanville, Daniel C Chambers, Peter Hopkins
BACKGROUND: The new anti-fibrotics pirfenidone and nintedanib are now in widespread use for idiopathic pulmonary fibrosis (IPF), but they may have an adverse impact on pathways involved in wound-healing. This study aimed to establish the safety of anti-fibrotic therapy in the peri-transplant period, particularly with regard to healing of the bronchial anastomosis. METHODS: In this work we assessed a retrospective cohort of patients who had undergone lung transplantation with a diagnosis of pulmonary fibrosis between January 2012 and December 2017...
February 12, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30819647/the-pleural-mesothelium-and-transforming-growth-factor-%C3%AE-1-pathways-in-restrictive-allograft-syndrome-a-pre-clinical-investigation
#9
Annelore Sacreas, Jan H von der Thüsen, Thierry P P van den Bosch, Birgit Weynand, Erik K Verbeken, Charlotte Debbaut, Dirk E Van Raemdonck, Robin Vos, Stijn E Verleden
BACKGROUND: Chronic lung allograft dysfunction (CLAD) hampers long-term survival after lung transplantation. Common fibrosis-related mechanisms in idiopathic pulmonary fibrosis and CLAD instigated the consideration of investigating the differential regulation of pleural mesothelium and transforming growth factor-β1 (TGF-β1 ) in restrictive allograft syndrome (RAS). METHODS: TGF-β1 was assessed in bronchoalveolar lavage (BAL) fluid using enzyme-linked immunoassay and via immune staining of explant biopsies...
February 6, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30795962/an-integrated-molecular-diagnostic-report-for-heart-transplant-biopsies-using-an-ensemble-of-diagnostic-algorithms
#10
Michael D Parkes, Arezu Z Aliabadi, Martin Cadeiras, Maria G Crespo-Leiro, Mario Deng, Eugene C Depasquale, Johannes Goekler, Daniel H Kim, Jon Kobashigawa, Alexandre Loupy, Peter Macdonald, Luciano Potena, Andreas Zuckermann, Philip F Halloran
BACKGROUND: We previously reported a microarray-based diagnostic system for heart transplant endomyocardial biopsies (EMBs), using either 3-archetype (3AA) or 4-archetype (4AA) unsupervised algorithms to estimate rejection. In the present study we examined the stability of machine-learning algorithms in new biopsies, compared 3AA vs 4AA algorithms, assessed supervised binary classifiers trained on histologic or molecular diagnoses, created a report combining many scores into an ensemble of estimates, and examined possible automated sign-outs...
February 6, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30773443/molecular-assessment-of-rejection-and-injury-in-lung-transplant-biopsies
#11
Kieran M Halloran, Michael D Parkes, Jessica Chang, Irina L Timofte, Gregory I Snell, Glen P Westall, Ramsey Hachem, Daniel Kreisel, Elbert Trulock, Antoine Roux, Stephen Juvet, Shaf Keshavjee, Peter Jaksch, Walter Klepetko, Philip F Halloran
BACKGROUND: Improved understanding of lung transplant disease states is essential because failure rates are high, often due to chronic lung allograft dysfunction. However, histologic assessment of lung transplant transbronchial biopsies (TBBs) is difficult and often uninterpretable even with 10 pieces. METHODS: We prospectively studied whether microarray assessment of single TBB pieces could identify disease states and reduce the amount of tissue required for diagnosis...
February 6, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30772111/transplant-outcomes-for-idiopathic-pulmonary-hypertension-in-children
#12
LETTER
Richard Hubbard, Rebecca Miller, Dmitry Tumin, Joseph D Tobias, Don Hayes
No abstract text is available yet for this article.
February 5, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30744940/a-comparison-of-low-and-standard-anti-coagulation-regimens-in-extracorporeal-membrane-oxygenation
#13
Jaishankar Raman, Mazahir Alimohamed, Nikola Dobrilovic, Omar Lateef, Salim Aziz
BACKGROUND: Bleeding and need for blood products are major complications associated with extracorporeal membrane oxygenation (ECMO) use. This study evaluated bleeding complications with low and standard heparinization protocols in the maintenance of venoarterial (VA)-ECMO. METHODS: A retrospective comparison was performed of 2 methods of heparinization in a contemporaneous series of adult patients supported with VA-ECMO at Rush University Medical Center, between November 2011 and November 2016...
January 31, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30765304/montelukast-for-chronic-lung-allograft-dysfunction-not-quite-the-full-monty
#14
EDITORIAL
Allan R Glanville
No abstract text is available yet for this article.
January 30, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30770267/timing-of-mechanically-assisted-circulatory-support
#15
EDITORIAL
Jacob Bergsland
No abstract text is available yet for this article.
January 29, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30745084/avoidance-of-outflow-graft-extrinsic-compression-in-polytetrafluoroethylene-reinforcements-of-the-bend-relief-component
#16
LETTER
E V Potapov, F Kaufmann, M Mueller, J Mulzer, C Starck, V Falk
No abstract text is available yet for this article.
January 29, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30765305/quality-of-death-after-left-ventricular-assist-device-implantation-more-questions-than-answers
#17
EDITORIAL
Akshay S Desai, Kristen G Schaefer, James A Tulsky, Mandeep R Mehra
No abstract text is available yet for this article.
January 25, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30737006/blood-pressure-in-a-mechanically-assisted-circulation-heat-spirit-perfection
#18
EDITORIAL
Joanna M Joly, Salpy V Pamboukian
No abstract text is available yet for this article.
January 25, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30733157/exercise-cardiovascular-magnetic-resonance-imaging-allows-differentiation-of-low-risk-pulmonary-arterial-hypertension
#19
Christoffer Göransson, Niels Vejlstrup, Jørn Carlsen
BACKGROUND: Patients with pulmonary arterial hypertension (PAH) have a decreased ability to compensate for demands on increased cardiac output, such as during exercise. In this study we aimed to differentiate cardiac exercise responses in patients with PAH, stratified according to known measurements of disease severity. METHODS: Right and left ventricular end-diastolic volume and end-systolic volume, stroke volume (SV), and cardiac output were measured in 20 patients with PAH and a lower risk of mortality with 6-month intervals using cardiovascular magnetic resonance (CMR) imaging during rest and during ergometer exercise (totaling 44 scans)...
January 25, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30733155/outcomes-in-cystic-fibrosis-lung-transplant-recipients-infected-with-organisms-labeled-as-pan-resistant-an-ishlt-registry%C3%A2-based-analysis
#20
Cecilia Lay, Nancy Law, Are Martin Holm, Christian Benden, Saima Aslam
BACKGROUND: The presence of pan-resistant organisms in patients with cystic fibrosis (CF) potentially impacts mortality after lung transplant (LT). In this study we aimed to study LT mortality in CF patients with and without pan-resistant infection. METHODS: The International Society for Heart and Lung Transplantation (ISHLT) Thoracic Transplant Registry was used to identify adults with CF, first-time, bilateral LT from 1991 to 2015. Extracted data included demographics, clinical characteristics, post-transplant outcomes, and mortality (infection-related, overall)...
January 25, 2019: Journal of Heart and Lung Transplantation
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