Journals Journal of Heart and Lung Tran...

Journal of Heart and Lung Transplantation
Sarah Chuzi, Elizabeth Cabrera, Onyedika Ilonze, Alyssa Vela, Lindsay Pifer, Tingqing Wu, Abigail S Baldrige, Rebecca Harap, Quentin Youmans, Kambiz Ghafourian, Anjan Tibrewala
It is unknown whether racial disparities in access to heart transplantation (HT) are amplified when coupled with substance use. We examined patients evaluated for HT over eight years at an urban transplant center. We evaluated substance use and race/ethnicity as independent and interactive predictors of HT and left ventricular assist device (LVAD) implantation. Of 1148 patients evaluated for HT, substance use was cited as an ineligibility factor in 151 (13%) patients, 16 (11%) of whom ultimately received HT...
May 17, 2024: Journal of Heart and Lung Transplantation
Shriprasad R Deshpande, Robert Gajarski, Bibhuti Das, Wenying Zhang, David Peng, Antonio Cabrera, Kurt Schumacher
BACKGROUND: Few studies highlighting the critical care management of patients after heart HTx (HTx) have been published to date. This analysis provides a contemporary representation of critical care burden pre- and post-HTx, describes care differences based on pre-transplant diagnosis and outlines the impact of intensive care unit (ICU) therapies on outcomes. METHODS: Data from PC4 Collaborative Registry was analyzed for pediatric patients undergoing HTx between 08/2014-04/2022...
May 16, 2024: Journal of Heart and Lung Transplantation
Kathleen L Grady, Mary Amanda Dew, Francis D Pagani, John A Spertus, Eileen Hsich, Melana Yuzefpolskaya, Brent Lampert, James K Kirklin, Michael Petty, Andrew Kao, Clyde Yancy, Justin Hartupee, Salpy V Pamboukian, Maryl Johnson, Margaret Murray, Tingqing Wu, Adin-Cristian Andrei
BACKGROUND: The quality-adjusted life year (QALY) measures disease burden and treatment, combining overall survival and health-related quality of life (HRQOL). We estimated QALYs in three groups of older patients (60-80 years) with heart failure (HF) who underwent heart transplantation (HT, with pre-transplant mechanical circulatory support [HT MCS] or HT without pre-transplant MCS [HT Non-MCS]) or long-term MCS (destination therapy). We also identified factors associated with gains in QALYs through 24 months follow-up...
May 16, 2024: Journal of Heart and Lung Transplantation
Kiran Khush, Shelley Hall, Andrew Kao, Nirav Raval, Ravi Dhingra, Palak Shah, Lavanya Bellumkonda, Ashwin Ravichandran, Adrian Van Bakel, Nir Uriel, Snehal Patel, Sean Pinney, Eugene DePasquale, David Baran, Kevin Pinney, Kris Oreschak, Jeremy Kobulnik, Ling Shen, Jeffrey Teuteberg
BACKGROUND: Molecular testing with gene expression profiling (GEP) and donor-derived cell-free DNA (dd-cfDNA) is increasingly used in the surveillance for acute cellular rejection (ACR) after heart transplant. However, the performance of dual testing over each test individually has not been established. Further, the impact of dual non-invasive surveillance on clinical decision-making has not been widely investigated. METHODS: We evaluated 2077 subjects from the SHORE registry who were enrolled between 2018 and 2021 and had verified biopsy data, and were categorized as dual negative, GEP positive/dd-cfDNA negative, GEP negative/dd-cfDNA positive, or dual positive...
May 15, 2024: Journal of Heart and Lung Transplantation
Misaki Kanezawa, Hiroto Shimokawahara, Kentaro Ejiri, Chiaki Goten, Hirofumi Okada, Kimi Sato, Shinsuke Yuasa, Hiromi Matsubara
BACKGROUND: Some patients with chronic thromboembolic pulmonary hypertension (CTEPH) exhibit exercise intolerance due to reduced cardiac output (CO) even after successful balloon pulmonary angioplasty (BPA). Medical therapy is a potential option for such cases; however, it is unclear which patients necessitate it even after BPA. METHODS: This study included 286 patients with CTEPH who underwent BPA and right heart catheterization one year after the final BPA and classified them into No-medication and Withdrawal groups...
May 15, 2024: Journal of Heart and Lung Transplantation
Mohammad Az Al-Ani, Maryjane A Farr, Palak Shah
No abstract text is available yet for this article.
May 15, 2024: Journal of Heart and Lung Transplantation
Grunde Gjesdal, Rebecca Tremain Rylance, Niklas Bergh, Göran Dellgren, Oscar Ö Braun, Johan Nilsson
BACKGROUND: Previous studies have demonstrated an association between the annual transplantation rate per center and post-operative mortality after heart transplantation. In 2011, Sweden centralized heart transplants and waiting lists, reducing the number of centers from three to two. This study aimed to assess the active waiting time and pre- and post-transplant mortality rates before and after centralization. METHODS: Heart transplantations performed in Sweden between January 1, 2001, and December 31, 2020, were included...
May 12, 2024: Journal of Heart and Lung Transplantation
Ian Nickel, Evgenij Potapov, Benjamin Sun, Daniel Zimpfer, Antigone Koliopoulou, Iki Adachi, Anelechi Anyanwu, Volkmar Falk, Pavan Atluri, Gloria Faerber, Daniel Goldstein, Leora Yarboro, Mark S Slaughter, Carmelo Milano, Masaki Tsukashita, David D'Alessandro, Scott Silvestry, Hristo Kirov, Swaroop Bommareddi, Pia Lanmüller, Torsten Doenst, Craig H Selzman
Left ventricular assist devices (LVAD) are excellent therapies for advanced heart failure patients either bridged to transplant or for lifetime use. LVADs also allow for reverse remodeling of the failing heart that is often associated with functional improvement. Indeed, growing enthusiasm exists to better understand this population of patients whereby the LVAD is used as an adjunct to mediate myocardial recovery. When patients achieve benchmarks suggesting that they no longer need LVAD support, questions related to discontinuation of LVAD therapy become front and center...
May 12, 2024: Journal of Heart and Lung Transplantation
Ioannis Gialamas, Alexandra Arvanitaki, Stephan Rosenkranz, S John Wort, Göran Rådegran, Roberto Badagliacca, George Giannakoulas
BACKGROUND: Contemporary patients with pulmonary arterial hypertension (PAH) are older and exhibit cardiovascular and/or lung comorbidities. Such patients have typically been excluded from major PAH drug trials. This systematic review compares baseline characteristics, hemodynamic parameters, and mortality rate between PAH patients with significant number of comorbidities compared to those with fewer or no comorbidities. ΜETHODS: A systematic literature search in PubMed and Cochrane databases was conducted searching for studies comparing PAH patients with more than two cardiovascular comorbidities and/or at least a lung comorbidity against those with fewer comorbidities...
May 12, 2024: Journal of Heart and Lung Transplantation
Melana Yuzefpolskaya, Bruno Bohn, Annamaria Ladanyi, Alberto Pinsino, Lorenzo Braghieri, Matthew R Carey, Kevin Clerkin, Gabriel T Sayer, Farhana Latif, Takeda Koji, Nir Uriel, Renu Nandakumar, Anne-Catrin Uhlemann, Paolo C Colombo, Ryan T Demmer
BACKGROUND: Sarcopenia, characterized by loss of muscle mass and function, is prevalent in heart failure (HF) and predicts poor outcomes. We investigated alterations in sarcopenia index (SI), a surrogate for skeletal muscle mass, in HF, left ventricular assist device (LVAD) and heart transplant (HT), and assessed its relationship with inflammation and digestive tract (gut and oral) microbiota. METHODS: We enrolled 460 HF, LVAD and HT patients. Repeated measures pre/post procedures were obtained prospectively in a subset of LVAD and HT patients...
May 12, 2024: Journal of Heart and Lung Transplantation
Xianqiang Wang, Xingtong Zhou, Haibo Chen, Juan Du, Ping Qing, Liang Zou, Yi Chen, Fujian Duan, Su Yuan, Jia Shi, Bingyang Ji, Rong Wu, Yanming Zhang, Yan Jin, Shengshou Hu
PURPOSE: Left ventricular assist devices (LVADs) are well-established for treating end-stage heart failure, but this therapy is only available to Chinese patients in recent years. The CH-VAD is the first used fully magnetically levitated pump and the most widely used device in China. This study reports the long-term outcomes of a cohort supported by the CH-VAD for the first time. METHODS: From June 2017 to August 2023, 50 consecutive patients received CH-VAD implantation in Fuwai Hospital...
May 11, 2024: Journal of Heart and Lung Transplantation
Syed Shahyan Bakhtiyar, Tiffany E Maksimuk, Michael T Cain, Jordan R H Hoffman
No abstract text is available yet for this article.
May 10, 2024: Journal of Heart and Lung Transplantation
Yael Peled, Michelle M Kittleson
No abstract text is available yet for this article.
May 3, 2024: Journal of Heart and Lung Transplantation
Michael B Keller, David Newman, Muhtadi Alnababteh, Lucia Ponor, Pali Shah, Joby Matthews, Hyesik Kong, Temesgen Andargie, Woojin Park, Ananth Charya, Helen Luikart, Shambhu Aryal, Steven D Nathan, Jonathan B Orens, Kiran K Khush, Moon Jang, Sean Agbor-Enoh
BACKGROUND: Lung transplant recipients are traditionally monitored with pulmonary function testing (PFT) and lung biopsy to detect post-transplant complications and guide treatment. Plasma donor-derived cell free DNA (dd-cfDNA) is a novel molecular approach of assessing allograft injury, including subclinical allograft dysfunction. The aim of this study was to determine if episodes of extreme molecular injury (EMI) in lung transplant recipients increases the risk of CLAD or death. METHODS: This multicenter prospective cohort study included 238 lung transplant recipients...
May 3, 2024: Journal of Heart and Lung Transplantation
Johnie Rose, Paul R Gunsalus, Carli J Lehr, Mark F Swiler, Jarrod E Dalton, Maryam Valapour
BACKGROUND: We describe and validate a new simulation framework addressing important limitations of the Simulated Allocation Models (SAMs) long used to project population effects of transplant policy changes. METHODS: We developed the Computational Open-source Model for Evaluating Transplantation (COMET), an agent-based model simulating interactions of individual donors and candidates over time to project population outcomes. COMET functionality is organized into interacting modules...
May 3, 2024: Journal of Heart and Lung Transplantation
Heidi A Kim, Andrew G Yu, Nicole P Kim, Mehreen S Iqbal, Ryan Butts
BACKGROUND: The Child Opportunity Index (COI) comprehensively measures children's social determinants of health. We describe association between COI and outcomes after listing for heart transplantation. METHODS: We conducted a retrospective review of the United Network for Organ Sharing (UNOS) database for U.S. children listed for heart transplant between 2012 and 2020. ZIP codes were utilized to assign COI. Primary outcome was survival from time of listing. Secondary outcomes included waitlist survival, one-year post-transplant survival, and conditional one-year post-transplant survival...
May 2, 2024: Journal of Heart and Lung Transplantation
Christopher S Almond, Ryan Davies, Iki Adachi, Marc Richmond, Sabrina Law, Hari Tunuguntla, Chad Mao, Fawwaz Shaw, Jodie Lantz, Peter D Wearden, Lori C Jordan, Rebecca N Ichord, Kristin Burns, Victor Zak, Ashley Magnavita, Selena Gonzales, Jennifer Conway, Aamir Jeewa, D 'Andrea Freemon, Mario Stylianou, Lynn Sleeper, John C Dykes, Michael Ma, Francis Fynn-Thompson, Angela Lorts, David Morales, Christina Vanderpluym, Kurt Dasse, M Patricia Massicotte, Robert Jaquiss, William T Mahle
BACKGROUND: There is no FDA-approved left ventricular assist device (LVAD) for smaller children permitting routine hospital discharge. Smaller children supported with LVADs typically remain hospitalized for months awaiting heart transplant-a major burden for families and a challenge for hospitals. We describe the initial outcomes of the Jarvik 2015, a miniaturized implantable continuous flow LVAD, in the NHLBI-funded Pumps for Kids, Infants, and Neonates (PumpKIN) study, for bridge-to-heart transplant...
April 30, 2024: Journal of Heart and Lung Transplantation
Kathleen L Grady, Michael A Kallen, David Cella, Larry A Allen, JoAnn Lindenfeld, Colleen K McIlvennan, David G Beiser, Mary Norine Walsh, Quin E Denfeld, Christopher S Lee, Bernice Ruo, Catherine Murks, Josef Stehlik, James K Kirklin, Jeffrey Teuteberg, Eric Adler, Michael Kiernan, Jonathan Rich, Katy Bedjeti, Elizabeth A Hahn
BACKGROUND: Patient-reported outcome (PRO) measures of distinct concepts are often put together into patient profile assessments. When brief, profile assessments can decrease respondent burden and increase measure completion rates. In this report, we describe creation of five self-reported 4-item short forms and the MCS A-QOL 20-item profile to assess PROs specific to adjustment and health-related quality of life (HRQOL) among patients who undergo left ventricular assist device (LVAD) implantation...
April 29, 2024: Journal of Heart and Lung Transplantation
Kelly Bryce, Juliane K Vierecke
No abstract text is available yet for this article.
April 27, 2024: Journal of Heart and Lung Transplantation
Jacopo Fumagalli, Veronica Punzi, Vittorio Scaravilli, Serena Maria Passamonti, Letizia Corinna Morlacchi, Valeria Rossetti, Anna Maraschini, Caterina Matinato, Margherita Brivio, Ilaria Righi, Francesco Blasi, Alessandra Bandera, Lorenzo Rosso, Mauro Panigada, Alberto Zanella, Giacomo Grasselli
BACKGROUND: Inconsistent data exists regarding the risk factors for bronchoalveolar lavage (BAL) positivity in lung donors, the incidence of donor-derived infections (DDI), and the effect of BAL positivity on lung transplant (LuTx) recipients' outcome. METHODS: A retrospective analysis was conducted on consecutive LuTx at a single center from January 2016 to December 2022. Donors' data, including characteristics, graft function and BAL samples were collected pre-procurement...
April 25, 2024: Journal of Heart and Lung Transplantation
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