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LETTER
Yoichiro Natori, Shweta Anjan, Jacques Simkins, Lilian Abbo, Suresh Manickavel, Juan Salgado, Neeraj Sinha, Mauricio Pipkins, Andres Pelaez, Tiago Machuca
No abstract text is available yet for this article.
June 1, 2023: Journal of Heart and Lung Transplantation
#2
EDITORIAL
Shivank Madan, Vagish Hemmige, Ulrich P Jorde
No abstract text is available yet for this article.
May 31, 2023: Journal of Heart and Lung Transplantation
#3
EDITORIAL
Melissa A Lyle, Stephen W English, Rohan M Goswami, Juan C Leoni Moreno, Jose Nativi-Nicolau, Daniel S Yip, Parag C Patel
Donation after circulatory death (DCD) is becoming increasingly utilized in heart transplantation and has the potential to further expand the donor pool. As transplant cardiologists gain more familiarity with DCD donor selection, there are many issues that lack consensus including how we incorporate the neurologic examination, how we measure functional warm ischemic time (fWIT), and what fWIT thresholds are acceptable. DCD donor selection calls for prognostication tools to help determine how quickly a donor may expire, and in current practice there is no standardization in how we make these predictions...
May 31, 2023: Journal of Heart and Lung Transplantation
#4
EDITORIAL
A Siddique, K R Parekh, S J Huddleston, A Shults, J E Locke, S Keshavamurthy, G Schwartz, M G Hartwig, B A Whitson
Thoracic organ recovery and implantation is increasing in complexity. Simultaneously the logistic burden and associated cost is rising. An electronic survey distributed to the surgical directors of thoracic transplant programs in the United States indicated dissatisfaction amongst 72% of respondents with current procurement training and 85% of respondents favored a process for certification in thoracic organ transplantation. These responses highlight concerns for the current paradigm of training in thoracic transplantation...
May 31, 2023: Journal of Heart and Lung Transplantation
#5
JOURNAL ARTICLE
Spenser E January, Keith A Fester, Laura P Halverson, Chad A Witt, Derek E Byers, Rodrigo Vazquez-Guillamet, Jennifer Alexander-Brett, Laneshia K Tague, Daniel Kreisel, Andrew Gelman, Varun Puri, Ruben Nava Bahena, Tsuyoshi Takahashi, Ramsey R Hachem, Hrishikesh S Kulkarni
Tocilizumab (TCZ), an IL-6 inhibitor, has shown promise in the treatment of donor-specific antibodies (DSA) and chronic antibody-mediated rejection (AMR) in renal transplant recipients. However, its use in lung transplantation has not been described. This retrospective case-control study compared AMR treatments containing TCZ in nine bilateral lung transplant recipients to 18 patients treated for AMR without TCZ. Treatment with TCZ resulted in more clearance of DSA, lower recurrence of DSA, lower incidence of new DSA, and lower rates of graft failure when compared to those treated for AMR without TCZ...
May 31, 2023: Journal of Heart and Lung Transplantation
#6
JOURNAL ARTICLE
Ersilia M DeFilippis, Ziyu Ji, Maria Masotti, Valmiki Maharaj, Tamas Alexy, Michelle M Kittleson, Rebecca Cogswell
BACKGROUND: The impact of heart transplant (HT) waitlist candidate sensitization on waitlist outcomes in the US is unknown. METHODS: Adult waitlist outcomes in OPTN (Oct 2018 - Sept 2022) by calculated panel reactive antibody (cPRA) were modeled to identify thresholds of clinical significance. The primary outcome was the rate of HT by cPRA category (low: 0-35, middle: >35-90, high: >90) assessed using multivariable competing risk analysis (compete: waitlist removal for death or clinical deterioration)...
May 31, 2023: Journal of Heart and Lung Transplantation
#7
JOURNAL ARTICLE
Basheer Elsolh, Zubair Bayat, Dennis Lyu, Jules Lin, Elliot Wakeam
OBJECTIVE: Lung transplant (LTx) is an accepted treatment for end-stage pulmonary failure. A small proportion of explanted lungs harbor incidentally identified non-small cell lung cancers (NSCLC). We review the literature on studies assessing LTx patients found to have NSCLC lung cancer in their explanted lungs, and perform a pooled analysis of outcomes. METHODS: MEDLINE, EMBASE, the Cochrane Database of Systematic Reviews, and the Cochrane Central Register of Controlled Trials were searched...
May 28, 2023: Journal of Heart and Lung Transplantation
#8
JOURNAL ARTICLE
Melissa Pitton, Luca G Valente, Simone Oberhaensli, Carlo Casanova, Parham Sendi, Bruno Schnegg, Stephan M Jakob, David R Cameron, Yok-Ai Que, Monika Fürholz
BACKGROUND: Driveline infections (DLIs) at the exit site are frequent in patients with left ventricular assist devices (LVADs). The dynamics from colonization to infection are yet to be investigated. We combined systematic swabbing at the driveline exit site and genomic analyses to study the dynamics of bacterial pathogens and get insights into DLIs pathogenesis. METHODS: A prospective, observational, single-centre cohort study at the University Hospital of Bern, Switzerland was performed...
May 26, 2023: Journal of Heart and Lung Transplantation
#9
JOURNAL ARTICLE
L G Gordon, P Hopkins, D Chambers, A C Green
BACKGROUND: Skin cancers are a major source of morbidity in lung transplant recipients but relative costs associated with their treatment are unknown. METHODS: We prospectively followed 90 lung transplant recipients from enrolment in the Skin Tumours in Allograft Recipients study in 2013 to 2015, until mid-2016. We undertook a cost-analysis to quantify the health system costs relating to the index transplant episode, and ongoing costs for four years. Linked data from surveys, Australian Medicare claims and hospital accounting systems were used and generalized linear models were employed...
May 25, 2023: Journal of Heart and Lung Transplantation
#10
Diyar Saeed, David Feldman, Aly El Banayosy, Emma Birks, Elizabeth Blume, Jennifer Cowger, Christopher Hayward, Ulrich Jorde, Jamila Kremer, Guy MacGowan, Simon Maltais, Simon Maybaum, Mandeep Mehra, Paul Mohacsi, Martin Schweiger, Sarah E Schroeder, Palak Shah, Marvin Slepian, Laurens F Tops, Paulino Alvarez, Francisco Arabia, Saima Aslam, Louis Benson-Louis, Edo Birati, Holger W Buchholz, Ari Cedars, Dawn Christensen, Agnieszka Ciarka, Erin Coglianese, Rebecca Cogswell, Jennifer Cook, Jack Copeland, Jose Gonzalez Costello, Stavros G Drakos, Pirooz Eghtesady, Tonya Elliot, Jerry D Estep, Jaime-Juergen Eulert-Grehn, De Rita Fabrizio, Jens Garbade, Jill Gelow, Maya Guglin, Jaime Hernandez-Montfort, Doug Horstmanshof, Ranjit John, Manreet Kanwar, Feras Khaliel, Gene Kim, Sachin Kumar, Jacob Lavee, Marzia Leache, Pascal Leprince, Sern Lim, Antonio Loforte, Jiri Maly, Samer Najjar, Ivan Netuka, Salpy V Pamboukian, Snehal R Patel, Sean Pinney, Christina Vander Pluym, Evgenij Potapov, Desiree Robson, Yogita Rochlani, Stuart Russell, Kristin Sandau, Elena Sandoval, Gabriel Sayer, Sarah Schettle, David Schibilsky, Thomas Schlöglhofer, Jan Schmitto, Aleem Siddique, Scott Silvestry, Mark S Slaughter, Benjamin Sun, Hiroo Takayama, Ryan Tedford, Jeffrey J Teuteberg, Van-Khue Ton, Nir Uriel, Juliane Vierecke, Daniel Zimpfer, David D'Alessandro
No abstract text is available yet for this article.
May 24, 2023: Journal of Heart and Lung Transplantation
#11
JOURNAL ARTICLE
Daniel Y Johnson, Daniel Ahn, Kevin Lazenby, Sharon Zeng, Kevin Zhang, Nikhil Narang, Kiran Khush, William F Parker
BACKGROUND: The US heart allocation system ranks candidates using six categorical status levels. Transplant programs can request exceptions to increase a candidate's status level if they believe their candidate has the same medical urgency as candidates who meet the standard criteria for that level. We aimed to determine if exception candidates have the same medical urgency as standard candidates. METHODS: Using the Scientific Registry of Transplant Recipients, we constructed a longitudinal waitlist history dataset of adult heart-only transplant candidates listed between October 18, 2018 and December 1, 2021...
May 22, 2023: Journal of Heart and Lung Transplantation
#12
JOURNAL ARTICLE
Jennifer A Frontera, Ariane Lewis, Les James, Kara Melmed, Brendan Parent, Eytan Raz, Syed T Hussain, Deane E Smith, Nader Moazami
Use of thoraco-abdominal normothermic regional perfusion (TA-NRP) during donation after circulatory death (DCD) is an important advance in organ donation. Prior to establishing TA-NRP, the brachiocephalic, left carotid, and left subclavian arteries are ligated, thereby eliminating anterograde brain blood flow via the carotid and vertebral arteries. While theoretical concerns have been voiced that TA-NRP after DCD may restore brain blood flow via collaterals, there have been no studies to confirm or refute this possibility...
May 19, 2023: Journal of Heart and Lung Transplantation
#13
JOURNAL ARTICLE
Dongling Luo, Xinpeng Zheng, Ziyang Yang, Hezhi Li, Hongwen Fei, Caojin Zhang
BACKGROUND: Patients with uncorrected isolated simple shunts associated pulmonary arterial hypertension (PAH) had increased mortality. Treatment strategies for borderline hemodynamics remain controversial. This study aims to investigate pre-closure characteristics and its association with post-closure outcome in this group of patients. METHODS: Adults with uncorrected isolated simple shunts associated PAH were included. Peak tricuspid regurgitation velocity <2...
May 19, 2023: Journal of Heart and Lung Transplantation
#14
JOURNAL ARTICLE
Ajay S Vaidya, Emily S Lee, Eric S Kawaguchi, Eugene C DePasquale, Kruti A Pandya, Michael W Fong, Jonathan Nattiv, Sylvia Villalon, Ashley Sertic, Ashley Cochran, Mary Alice Ackerman, Marie Melendrez, Rachel Cartus, Kori Ann Johnston, Raymond Lee, Aaron M Wolfson
BACKGROUND: The 2018 adult heart allocation policy sought to improve waitlist risk stratification, reduce waitlist mortality and increase organ access. This system prioritized patients at greatest risk for waitlist mortality, especially individuals requiring temporary mechanical circulatory support (tMCS). Post-transplant complications are significantly higher in patients on tMCS before transplantation, and early post-transplant complications impact long-term mortality. We sought to determine if policy change affected early post-transplant complication rates of rejection, infection and hospitalization...
May 19, 2023: Journal of Heart and Lung Transplantation
#15
JOURNAL ARTICLE
S Ashwin Reddy, Emilia M Swietlik, Lucy Robertson, Alice Michael, Sonja Boyle, Gary Polwarth, Nick J Screaton, Alessandro Ruggiero, Sarah L Nethercott, Dolores Taboada, Karen K Sheares, Charaka Haddinapola, John E Cannon, Katherine Bunclark, David Jenkins, Choo Ng, Mark R Toshner, Joanna Pepke-Zaba
INTRODUCTION: We describe baseline characteristics, disease progression and mortality in chronic thromboembolic pulmonary disease (CTEPD) patients as a function of mean pulmonary artery pressure (mPAP) according to new and previous definitions of pulmonary hypertension (PH). METHOD: All patients diagnosed with CTEPD between January 2015 and December 2019 were dichotomised according to initial mPAP: ≤20mmHg ('normal') vs. 21-24mmHg ('mildly-elevated'). Baseline features were compared between the groups, and pairwise analysis performed to determine changes in clinical endpoints at 1-year, excluding those who underwent pulmonary endarterectomy (PEA) or did not attend follow-up...
May 16, 2023: Journal of Heart and Lung Transplantation
#16
JOURNAL ARTICLE
Theresa Tran, Mohammed A Kashem, Ahad Firoz, Roh Yanagida, Norihisa Shigemura, Yoshiya Toyoda
BACKGROUND: Coronary artery disease (CAD) is common among lung transplant (LTx) candidates and has historically been viewed as a contraindication to the procedure. Survival outcomes of lung transplant recipients with concomitant coronary artery disease who had prior or perioperative revascularization remain a topic of conversation. METHODS: A retrospective analysis of all single and double lung transplant patients from Feb-2012 to Aug-2021 at a single center was performed (n = 880)...
May 13, 2023: Journal of Heart and Lung Transplantation
#17
JOURNAL ARTICLE
Shiwei Zhou, Guangyu Yang, Hechuan Hou, Min Zhang, Kathleen L Grady, Carol E Chenoweth, Keith D Aaronson, Michael Pienta, Michael D Fetters, P Paul Chandanabhumma, James W Stewart, Lourdes Cabrera, Preeti N Malani, Francis D Pagani, Donald S Likosky
BACKGROUND: Left ventricular assist device (LVAD) implantation leads to substantial and sustained improvement in health-related quality of life (HRQOL) among patients. Infection following device implantation remains an important and frequent complication and adversely affects patient-reported HRQOL. METHODS: Patients in The Society of Thoracic Surgeons' Interagency Registry for Mechanically Assisted Circulatory Support receiving a primary LVAD between April 2012 to October 2016 were included...
May 13, 2023: Journal of Heart and Lung Transplantation
#18
JOURNAL ARTICLE
Jessica R Golbus, Yoon Son Ahn, Grace R Lyden, Brahmajee K Nallamothu, David Zaun, Ajay K Israni, Mary Norine Walsh, Monica Colvin
BACKGROUND: The October 2018 update to the heart allocation policy was intended to decrease exception status requests, whereby candidates are listed at a specific status due to perceived need despite not meeting pre-specified criteria of illness severity. We assessed use of exception status and waitlist outcomes before and after the 2018 policy. METHODS: We used data from the Scientific Registry of Transplant Recipients on adult heart transplant candidates listed from 2015-2021...
May 12, 2023: Journal of Heart and Lung Transplantation
#19
JOURNAL ARTICLE
Guillaume Coutance, Jon A Kobashigawa, Evan Kransdorf, Alexandre Loupy, Eva Desiré, Michelle Kittleson, Jignesh K Patel
Allosensitization represents a major barrier to heart transplantation (HTx). We previously reported favorable 1-year outcomes of complement inhibition at transplant in highly sensitized recipients. We now report a longer follow-up. In this single-arm trial (NCT02013037), 20 patients with panel reactive antibodies ≥70% and pre-formed donor-specific antibodies received eculizumab during the first two months post-transplant. The primary endpoint was antibody-mediated rejection (AMR) ≥pAMR2 and/or left ventricular dysfunction...
May 12, 2023: Journal of Heart and Lung Transplantation
#20
LETTER
Ersilia M DeFilippis, Evan P Kransdorf, Abhishek Jaiswal, Xiaohai Zhang, Jignesh Patel, Jon A Kobashigawa, David A Baran, Michelle M Kittleson
No abstract text is available yet for this article.
May 9, 2023: Journal of Heart and Lung Transplantation
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