journal
Journals Journals of Gerontology. Serie...

Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

https://read.qxmd.com/read/38878282/are-we-adding-pain-free-years-to-life-a-test-of-compression-versus-expansion-of-morbidity
#1
JOURNAL ARTICLE
Zachary Zimmer, Feinuo Sun, Amber Duynisveld
BACKGROUND: There has been debate regarding whether increases in longevity result in longer and healthier lives or more disease and suffering. To address the issue, this paper uses health expectancy methods and tests an expansion versus compression of morbidity with respect to pain. METHODS: Data are from 1993 to 2018 Health and Retirement Study. Pain is categorized as no pain, non-limiting and limiting pain. Multistate life tables examine 77,996 wave-to-wave transitions across pain states or death using the Stochastic Population Analysis for Complex Events program...
June 15, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38877811/the-bispectral-electroencephalography-bseeg-method-quantifies-post-operative-delirium-like-states-in-young-and-aged-male-mice-after-head-mount-implantation-surgery
#2
JOURNAL ARTICLE
Tsuyoshi Nishiguchi, Kazuki Shibata, Kyosuke Yamanishi, Mia Nicole Dittrich, Noah Yuki Islam, Shivani Patel, Nathan James Phuong, Pedro S Marra, Johnny R Malicoat, Tomoteru Seki, Yoshitaka Nishizawa, Takehiko Yamanashi, Masaaki Iwata, Gen Shinozaki
Delirium, a syndrome characterized by an acute change in attention, awareness, and cognition, is commonly observed in older adults, although there are few quantitative monitoring methods in the clinical setting. We developed a bispectral electroencephalography (BSEEG) method capable of detecting delirium and can quantify the severity of delirium using a novel algorithm. Pre-clinical application of this novel BSEEG method can capture a delirium-like state in mice following LPS administration. However, its application to postoperative delirium (POD) has not yet been validated in animal experiments...
June 15, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38875006/gwas-identifies-dpp6-as-risk-gene-of-cognitive-decline-in-parkinson-s-disease
#3
JOURNAL ARTICLE
Chunyu Li, Yanbing Hou, Ruwei Ou, Qianqian Wei, Lingyu Zhang, Kuncheng Liu, Junyu Lin, Xueping Chen, Wei Song, Bi Zhao, Ying Wu, Huifang Shang
BACKGROUND: Cognitive decline is among the most common non-motor symptoms in Parkinson's disease (PD), while its physiological mechanisms remain poorly understood. Genetic factors constituted a fundamental determinant in the heterogeneity of cognitive decline among PD patients. However, the underlying genetic background was still less studied. METHODS: To explore the genetic determinants contributing to cognitive decline in PD, we performed genome-wide survival analysis using a Cox proportional hazards model in a longitudinal cohort of 450 Chinese patients with PD, and further explored the functional effect of the target variant...
June 14, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38872422/somatic-factors-predict-on-road-driving-skills-in-older-drivers-and-drivers-with-mild-cognitive-impairment
#4
JOURNAL ARTICLE
Maximilian Flieger, Wolf Schäbitz, Daniel A Schlueter, Kim L Austerschmidt, Jessica Koenig, Thomas Beblo, Martin Driessen, Max Toepper
BACKGROUND: On-road driving skills can be impaired in older drivers and in drivers with mild cognitive impairment (MCI) due to different driving-relevant deficits. Among these deficits, somatic factors have received little attention so far. METHODS: In a prospective observational on-road driving study, we examined whether somatic factors can predict on-road driving skills in a mixed sample of healthy older drivers and drivers with MCI (n = 99) and whether the inclusion of age explains additional variance...
June 14, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38869510/is-the-risk-of-alzheimer-s-disease-and-related-dementias-among-u-s-veterans-influenced-by-the-intersectionality-of-housing-status-hiv-aids-hepatitis-c-and-psychiatric-disorders
#5
JOURNAL ARTICLE
Hind A Beydoun, Dorota Szymkowiak, Rebecca Kinney, May A Beydoun, Alan B Zonderman, Jack Tsai
BACKGROUND: Homelessness and housing instability disproportionately affect U.S. veterans with psychiatric disorders, HIV/AIDS, hepatitis C, and Alzheimer's Disease and Related Disorders (ADRD). We examined housing status and/or HIV/AIDS in relation to ADRD risk and evaluated hepatitis C, substance use, and mental health disorders as mediators and/or moderators of hypothesized relationships, among U.S. veterans ≥ 50 years of age seeking Department of Veterans Affairs (VA) healthcare services...
June 13, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38855906/high-impact-pain-is-associated-with-epigenetic-aging-among-middle-aged-and-older-adults-findings-from-the-health-and-retirement-study
#6
JOURNAL ARTICLE
Javier A Tamargo, Larissa J Strath, Yenisel Cruz-Almeida
BACKGROUND: Chronic pain has been associated with accelerated biological aging, which may be related to epigenetic alterations. We evaluated the association of high-impact pain (i.e., pain that limits activities and function) with epigenetic aging, a measure of biological aging, in a nationally representative sample of middle-aged and older adults in the United States. METHODS: Cross-sectional analysis of adults 50 years of age and older from the 2016 Health and Retirement Study (HRS)...
June 10, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38853707/mettl3-promotes-nucleus-pulposus-cell-senescence-in-intervertebral-disc-degeneration-by-regulating-tlr2-m6a-methylation-and-gut-microbiota
#7
JOURNAL ARTICLE
Shuangfei Ni, Xiusheng Huang, Xuesen Li, Chenhao Shi, Mingzhe Fan, Lantian Zhao, Zijie Rong, Huafeng Zhang
BACKGROUND: Nucleus pulposus cell (NPC) senescence in intervertebral disc (IVD) tissue is the major pathological cause during intervertebral disc degeneration (IDD). N6-methyladenosine (m6A) methylation and gut microbiota play important roles in the progression of IDD. This study investigated whether methyltransferase-like 3 (METTL3) regulates TLR2 m6A modification and gut microbiota to influence NPC senescence. METHODS: An IDD rat model was established by lumbar intervertebral disc puncture and NPCs were challenged with IL-1β to mimic IVD injury...
June 10, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38853485/the-physiologic-complexity-of-prefrontal-oxygenation-dynamics-is-associated-with-age-and-executive-function-an-exploratory-study
#8
JOURNAL ARTICLE
Yinglu Hong, Junhong Zhou, Wanting Yu, Ikechukwu Iloputaife, Dapeng Bao, Yuncong Zhou, Brad Manor, Lewis A Lipsitz, Azizah J Jor'dan
BACKGROUND: The hemodynamics of prefrontal cortex (PFC) oxygenation are regulated by numerous processes operating over multiple temporal scales, producing complex patterns in its output fluctuations. Age may alter this multiscale regulation of PFC oxygenation, leading to diminished physiologic complexity of this important regulatory process. We aimed to characterize the effects of age on such complexity and its relationship to performance of an executive n-back task. METHODS: Twenty-four younger (aged 28±3 years) and 27 older (aged 78±6 years) adults completed this study...
June 10, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38845419/association-between-cognitive-trajectories-and-subsequent-health-status-depressive-symptoms-and-mortality-among-older-adults-in-the-united-states-findings-from-a-nationally-representative-study
#9
JOURNAL ARTICLE
Emma Zang, Yunxuan Zhang, Yi Wang, Bei Wu, Terri R Fried, Robert D Becher, Thomas M Gill
BACKGROUND: Cognitive decline may be an early indicator of major health issues in older adults, though research using population-based data is lacking. Our objective was to assess the relationships between distinct cognitive trajectories and subsequent health outcomes, including health status, depressive symptoms, and mortality, using a nationally representative cohort. METHODS: Data were drawn from the National Health and Aging Trends Study. Global cognition was assessed annually between 2011 and 2018...
June 7, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38837176/differential-responses-to-aging-amongst-the-transcriptome-and-proteome-of-mesenchymal-progenitor-populations
#10
JOURNAL ARTICLE
Jack Feehan, Nicholas Tripodi, Dmitry Kondrikov, Tissa Wijeratne, Jeffrey Gimble, William Hill, Vasso Apostolopoulos, Gustavo Duque
The biological aging of stem cells (exhaustion) is proposed to contribute to the development of a variety of age-related conditions. Despite this, little is understood about the specific mechanisms which drive this process. In this study, we assess the transcriptomic and proteomic changes in three different populations of mesenchymal progenitor cells from older (50-70 years) and younger (20-40 years) individuals to uncover potential mechanisms driving stem cell exhaustion in mesenchymal tissues. To do this, we harvested primary bone marrow mesenchymal stem and progenitor cells (MPCs), circulating osteoprogenitors (COP), and adipose-derived stem cells (ADSCs) from younger and older donors, with an equal number of samples from males and females...
June 5, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38836313/change-in-healthy-lifestyle-and-subsequent-risk-of-cognitive-impairment-among-chinese-older-adults-a-national-community-based-cohort-study
#11
JOURNAL ARTICLE
Chengxiang Hu, Kexin Jiang, Xiaoyue Sun, Yue He, Runhong Li, Yana Chen, Yuan Zhang, Yuchun Tao, Lina Jin
BACKGROUND: The association between change in lifestyle and cognitive impairment remains uncertain. OBJECTIVE: To investigate the association of change in lifestyle with cognitive impairment. METHODS: In this study, 4,938 participants aged 65 or above were involved from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) for years of 2008-2018. A weighted healthy lifestyle score was derived from four lifestyle factors (smoking, alcohol consumption, physical activity, and diet)...
June 5, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38833180/association-of-frailty-with-risk-of-incident-hospital-treated-infections-in-middle-aged-and-older-adults-a-large-scale-prospective-cohort-study
#12
JOURNAL ARTICLE
Minzhi Xu, Yanhong Gong, Xiaoxv Yin
BACKGROUND: Although frailty is associated with a range of adverse health outcomes, its association with the risk of hospital-treated infections is uncertain. METHODS: A total of 416220 participants from the UK Biobank were included in this prospective cohort study. Fried phenotype was adopted to evaluate frailty, which included five aspects (gait speed, physical activity, grip strength, exhaustion, and weight). More than 800 infectious diseases were identified based on electronic health records...
June 4, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38813979/does-social-support-moderate-the-relationship-between-frailty-and-functional-ability-trajectory-among-community-dwelling-older-adults
#13
JOURNAL ARTICLE
Jiaqi Yu, Huaxin Si, Qinqin Liu, Yanyan Li, Wendie Zhou, Cuili Wang
BACKGROUND: Functional ability is the important prerequisite to live independently and achieve aging in place, which depends on the complex interaction of intrinsic and extrinsic factors. Identifying the trends and influencing factors of functional ability would contribute to the accurate assessment and intervention of geriatric health. This study aimed to disentangle the moderating effect of three types of social support, namely objective support, subjective support and support utilization, on the relationship between frailty and functional ability trajectories...
May 30, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38808484/whole-genome-linkage-and-association-analyses-identify-dlg-associated-protein-1-as-a-novel-positional-and-biological-candidate-gene-for-muscle-strength-the-long-life-family-study
#14
JOURNAL ARTICLE
Adam J Santanasto, Sandeep Acharya, Mary K Wojczynski, Ryan K Cvejkus, Shiow Lin, Michael R Brent, Jason A Anema, Lihua Wang, Bharat Thyagarajan, Kaare Christensen, E Warwick Daw, Joseph M Zmuda
BACKGROUND: Grip strength is a robust indicator of overall health, is moderately heritable, and predicts longevity in older adults. METHODS: Using genome-wide linkage analysis, we identified a novel locus on chromosome 18p (mega-basepair region: 3.4 - 4.0) linked to grip strength in 3755 individuals from 582 families aged 64 ± 12 years (range 30-110 years; 55% women). There were 26 families that contributed to the linkage peak (cumulative logarithm of the odds [LOD] score = 10...
May 29, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38801341/projecting-long-term-care-costs-among-older-adults-with-adl-disability-and-cognitive-impairment-in-china
#15
JOURNAL ARTICLE
Haiyu Jin, Chenkai Wu
BACKGROUND: Mounting evidence suggests that cognitive impairment is strongly associated with difficulties in performing activities of daily living (ADL disability). This study aims to estimate and project the trend in the number of older adults in China with ADL disability and cognitive impairment and the associated long-term care (LTC) costs in the next 20 years. METHODS: We used data from 37,942 adults aged ≥ 65 years from waves 2005-2018 of the Chinese Longitudinal Healthy Longevity Surveys (CLHLS)...
May 27, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38795337/association-of-cardiovascular-fibrosis-remodeling-and-dysfunction-with-frailty-pre-frailty-and-functional-performance-the-multi-ethnic-study-of-atherosclerosis-mesa
#16
JOURNAL ARTICLE
Jaclyn Sesso, Jeremy Walston, Karen Bandeen-Roche, Colin Wu, Alain G Bertoni, Sanjiv Shah, Joao A C Lima, Bharath Ambale-Venkatesh
BACKGROUND: Cardiovascular disease is associated with higher incidence of frailty. However, the nature of the mechanisms underlying this association remain unclear. The purpose of this study is to identify cardiovascular phenotypes most associated with physical frailty and functional performance in the Multi-Ethnic Study of Atherosclerosis (MESA). METHODS: As part of the MESA study, 3045 participants underwent cardiovascular magnetic resonance and computed tomography between 2010-2012...
May 25, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38784975/association-of-exposure-to-ambient-air-pollutants-with-cognitive-performance-and-dementia-risk-and-the-mediating-role-of-pulmonary-function-evidence-from-the-uk-biobank
#17
JOURNAL ARTICLE
Fabin Lin, Lili Wang, Yisen Shi, Xuanjie Chen, Yixiang Lin, Jiayi Zheng, Ke Chen, Qinyong Ye, Guoen Cai
BACKGROUND: The pathways by which air pollution affects cognition remain to be explored. This study aimed to explore how single air pollutants [including nitrogen oxide (NOX), nitrogen dioxide (NO2), particulate matter with a diameter of 2.5 micrometers (PM2.5), PM10, and PM2.5-10], and air pollution mixture could affect cognitive function and the incidence of dementia, and determine whether pulmonary function (PF) could play a mediating role in the relationship. METHODS: Multiple statistical methods were employed to evaluate association of five air pollutants (NOX, NO2, PM2...
May 24, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38777885/neighborhood-walkability-is-associated-with-global-positioning-system-gps-derived-community-mobility-of-older-adults
#18
JOURNAL ARTICLE
Kyle D Moored, Breanna M Crane, Michelle C Carlson, Pamela M Dunlap, Jennifer S Brach, Andrea L Rosso
BACKGROUND: Neighborhood walkability may encourage greater out-of-home travel (i.e., community mobility) to support independent functioning in later life. We examined associations between a novel walkability audit index and Global Positioning System (GPS)-derived community mobility in community-dwelling older adults. We compared associations with the validated Environmental Protection Agency (EPA) National Walkability Index and further examined moderation by clinical walking speed. METHODS: Participants were 146 older adults (Mean=77...
May 23, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38775400/sex-differences-in-the-trajectories-of-cognitive-decline-and-affected-cognitive-domains-among-older-adults-with-controlled-and-uncontrolled-glycemia
#19
JOURNAL ARTICLE
Natália Cochar-Soares, Dayane C de Oliveira, Mariane M Luiz, Márlon J R Aliberti, Claudia K Suemoto, Andrew Steptoe, Cesar de Oliveira, Tiago S Alexandre
BACKGROUND: We aimed to analyze the trajectories of cognitive decline as a function of the presence of type 2 diabetes and glycemic control in analyzes stratified by sex in an eight-year follow-up period. METHODS: A total of 1,752 men and 2,232 women aged ≥50 years who participated in the English Longitudinal Study of Ageing (ELSA), conducted from 2004 to 2012, were analyzed. The outcomes of interest were performance on the cognitive domains of memory, executive function, and temporal orientation as well as the global cognition score...
May 22, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38766839/apolipoprotein-%C3%A9-4-is-associated-with-increased-risk-of-fall-and-fracture-related-hospitalisation-the-perth-longitudinal-study-of-ageing-women
#20
JOURNAL ARTICLE
Jedd Pratt, Jack Dalla Via, Craig Sale, Abadi K Gebre, Blossom C M Stephan, Simon Laws, Kun Zhu, Wai H Lim, Richard L Prince, Joshua R Lewis, Marc Sim
Apolipoprotein ɛ4 (APOE ɛ4) may be a genetic risk factor for reduced bone mineral density (BMD) and muscle function, which could have implications for fall and fracture risk. We examined the association between APOE ɛ4 status and long-term fall- and fracture-related hospitalisation risk in older women. 1276 community-dwelling women from the Perth Longitudinal Study of Ageing Women (mean age ± SD = 75.2 ± 2.7 years) were included. At baseline, women underwent APOE genotyping and detailed phenotyping for covariates including prevalent falls and fractures, as well as health and lifestyle factors...
May 20, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
journal
journal
20151
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.