Megan Hetherington-Rauth, Eileen Johnson, Eugenia Migliavacca, Neeta Parimi, Lisa Langsetmo, Russell T Hepple, Yohan Grzywinski, John Corthesy, Terence E Ryan, Luigi Ferrucci, Jérôme N Feige, Eric S Orwoll, Peggy M Cawthon
BACKGROUND: The relationship between amino acids (AA), B-vitamins, and their metabolites with D3-creatine dilution (D3Cr) muscle mass, a more direct measure of skeletal muscle mass, has not been investigated. We aimed to assess associations of plasma metabolites with D3Cr muscle mass, as well as muscle strength and physical performance in older men from the Osteoporotic Fractures in Men (MrOS) cohort study. METHODS: Out of 1,425 men (84.2±4.1yrs), men with the lowest D3Cr muscle mass (n=100), slowest walking speed (n=100), lowest grip strength (n=100), and a random sample (n=200) serving as a comparison group to the low groups were included...
September 11, 2023: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences