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Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

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https://read.qxmd.com/read/30778523/plagiarism-policy-and-practice
#1
Anne B Newman
No abstract text is available yet for this article.
February 19, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30778518/a-case-for-promoting-movement-medicine-preventing-disability-in-the-life-randomized-controlled-trial
#2
Jason Fanning, W Jack Rejeski, Shyh-Huei Chen, Barbara J Nicklas, Michael P Walkup, Robert S Axtell, Roger A Fielding, Nancy W Glynn, Abby C King, Todd M Manini, Mary M McDermott, Anne B Newman, Marco Pahor, Catrine Tudor-Locke, Michael E Miller
BACKGROUND: The movement profile of older adults with compromised function is unknown, as is the relationship between these profiles and the development of major mobility disability (MMD)-a critical clinical outcome. We first describe the dimensions of movement in older adults with compromised function and then examine whether these dimensions predict the onset of MMD. METHODS: Older adults at risk for MMD (N=1,022, mean age=78.7) were randomized to receive a structured physical activity (PA) intervention or health education control (HE)...
February 19, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30778527/multidimensional-sleep-and-mortality-in-older-adults-a-machine-learning-comparison-with-other-risk-factors
#3
Meredith L Wallace, Daniel J Buysse, Susan Redline, Katie Stone, Kristine Ensrud, Yue Leng, Sonia Ancoli-Israel, Martica H Hall
BACKGROUND: Sleep characteristics related to duration, timing, continuity, and sleepiness are associated with mortality in older adults, but rarely considered in health recommendations. We applied machine learning to: (1) establish the predictive ability of a multidimensional self-reported sleep domain for all-cause and cardiovascular mortality in older adults relative to other established risk factors; and (2) identify which sleep characteristics are most predictive. METHODS: The analytic sample includes N=8,668 older adults (54% female) aged 65-99 with self-reported sleep characterization and longitudinal follow-up (≤15...
February 18, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30772903/trends-in-risk-of-limitations-in-instrumental-activities-of-daily-living-over-age-in-older-persons-with-and-without-multiple-chronic-conditions
#4
Sigrid Mueller-Schotte, Nicolaas P A Zuithoff, Yvonne T van der Schouw, Marieke J Schuurmans, Nienke Bleijenberg
BACKGROUND: To investigate trends over age by comorbidity-status for the risk of limitations in individual activities of daily living for community-living older persons. METHODS: A longitudinal population-based study was conducted in 9,319 community-living Dutch persons aged 60 years and older. Self-reported MCC and nine IADLs were assessed in fifteen studies of the Dutch National Care for the Elderly Program (TOPICS-MDS). Risks of limitations in IADLs, odds ratios (per five years), and rate ratios (per five years) were calculated with mixed logistic and negative binomial regression models with age as the underlying time-scale, stratified by number of MCC (no, 1-2, ≥ 3 MCC), and corrected for confounders...
February 17, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30772901/blueberries-improve-neuroinflammation-and-cognition-differentially-depending-on-individual-cognitive-baseline-status
#5
Barbara Shukitt-Hale, Nopporn Thangthaeng, Marshall G Miller, Shibu M Poulose, Amanda N Carey, Derek R Fisher
Daily supplementation of blueberries (BBs) reverses age-related deficits in behavior in aged rats. However, it is unknown whether BB is more beneficial to one subset of the population dependent on baseline cognitive performance and inflammatory status. To examine the effect of individual differences on the efficacy of BB, aged rats (17 mo old) were assessed for cognition in the radial arm water maze (RAWM) and divided into good, average, and poor performers based on navigation errors. Half of the rats in each cognitive group were then fed a control or a 2% BB diet for 8 weeks before re-testing...
February 17, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30772894/sarcopenia-and-variation-in-the-human-leukocyte-antigen-complex
#6
Garan Jones, Luke C Pilling, Chia-Ling Kuo, George Kuchel, Luigi Ferrucci, David Melzer
BACKGROUND: Aging is characterized by chronic inflammation plus muscle mass and strength loss, termed sarcopenia. Human Leukocyte Antigen (HLA) types are drivers of autoimmune disease, although with limited penetrance. We tested whether autoimmune diagnoses are associated with sarcopenia, and whether HLA types and related genetic variants associate with sarcopenia in autoimmune disease free older people. METHODS: Data from 181,301 UK Biobank European descent volunteers aged 60 - 70 with measured hand-grip strength and impedance...
February 17, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30772905/circulating-anthocyanin-metabolites-mediate-vascular-benefits-of-blueberries-insights-from-randomized-controlled-trials-metabolomics-and-nutrigenomics
#7
Ana Rodriguez-Mateos, Geoffrey Istas, Lisa Boschek, Rodrigo P Feliciano, Charlotte E Mills, Céline Boby, Sergio Gomez-Alonso, Dragan Milenkovic, Christian Heiss
Potential health benefits of blueberries may be due to vascular effects of anthocyanins which predominantly circulate in blood as phenolic acid metabolites. We investigated which role blueberry anthocyanins and circulating metabolites play in mediating improvements in vascular function and explore potential mechanisms using metabolomics and nutrigenomics. Purified anthocyanins exerted a dose-dependent improvement of endothelial function in healthy humans, as measured by flow-mediated dilation (FMD). The effects were similar to those of blueberries containing similar amounts of anthocyanins while control drinks containing fiber, minerals, or vitamins had no significant effect...
February 16, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30770932/aging-alters-phenotypic-traits-of-thyroid-dysfunction-in-male-mice-with-divergent-effects-on-complex-systems-but-preserved-thyroid-hormone-action-in-target-organs
#8
Kathrin Engels, Helena Rakov, Georg Sebastian Hönes, Klaudia Brix, Josef Köhrle, Denise Zwanziger, Lars Christian Moeller, Dagmar Führer
Clinical manifestation of hyperthyroidism and hypothyroidism vary with age, with an attenuated, oligosymptomatic presentation of thyroid dysfunction (TD) in older patients. We asked, whether in rodents TD phenotypes are influenced by age and whether this involves changes in systemic and/or organ thyroid hormone (TH) signaling. Chronic hyper- or hypothyroidism was induced in male mice at different life stages (5, 12, 20 months). TH excess resulted in pronounced age-specific body weight changes (increase in youngest and decrease in old mice), neither explained by changes in food intake (similar increase at all ages), nor by thermogenic gene expression in brown adipose tissue (BAT) or TH serum concentrations...
February 16, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30753308/hearing-impairment-and-cognitive-decline-in-older-community-dwelling-adults
#9
Ali A Alattar, Jaclyn Bergstrom, Gail A Laughlin, Donna Kritz-Silverstein, Erin L Richard, Emilie T Reas, Jeffrey P Harris, Elizabeth Barrett-Connor, Linda K McEvoy
Background: Hearing impairment is prevalent among older adults and has been identified as a risk factor for cognitive impairment and dementia. We evaluated the association of hearing impairment with long-term cognitive decline among community-dwelling older adults. Methods: A population-based longitudinal study of adults not using hearing aids who had hearing acuity and cognitive function assessed in 1992-96, and were followed for a maximum of 24 years with up to five additional cognitive assessments...
February 12, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30753310/redox-parameters-as-markers-of-the-rate-of-aging-and-predictors-of-lifespan
#10
Irene Martínez de Toda, Carmen Vida, Antonio Garrido, Mónica De la Fuente
Oxidative stress has been reported to increase with aging and although several age-related changes in redox parameters have been described, none of them have been verified as markers of the rate of aging and lifespan. Therefore, antioxidant (catalase, glutathione peroxidase and reductase activities and reduced glutathione) and oxidant (oxidized glutathione, basal superoxide anion and malondialdehyde concentrations) parameters were studied in whole blood cells from humans divided into different age groups (adult, mature, elderly, nonagenarian and centenarian) in a cross-sectional study...
February 11, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30753301/association-between-antipsychotics-and-all-cause-mortality-among-community-dwelling-older-adults
#11
Raya Elfadel Kheirbek, Ali Fokar, John T Little, Marshall Balish, Nawar M Shara, Malaz A Boustani, Maria Llorente
Background: Antipsychotics are prescribed to treat various symptoms in older adults, however, their safely in this context has not been fully evaluated. The objective was to evaluate mortality risks associated with off- label use of antipsychotics among older adults with no pre-existing mental illness or dementia relative to those with diagnosis of dementia. Methods: Data (2007-2015) were derived from Department of Veterans Affairs registries for 730,226 patients (≥65 years) with no baseline serious mental illness, dementia)...
February 11, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30753307/john-o-holloszy-an-enduring-legacy-in-exercise-physiology-aging-and-muscle-research
#12
James Hagberg
No abstract text is available yet for this article.
February 9, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30753303/rehabilitation-after-hip-fracture-for-nursing-home-residents-a-controlled-feasibility-trial
#13
Lauren A Beaupre, Jay S Magaziner, C Allyson Jones, Gian S Jhangri, D William C Johnston, Donna M Wilson, Sumit R Majumdar
Background: This study compared function three-months after hip fracture surgery between nursing home residents participating in a 10-week outreach rehabilitation program and those receiving usual care. Function, health-related quality of life (HRQL) and mortality were also compared over 12-months and outreach program feasibility was assessed. Methods: A feasibility trial was undertaken in Canadian nursing homes; of 77 participants, 46 were allocated to Outreach and 31 to Control prior to assessing function or cognition...
February 9, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30753306/a-regression-tree-for-identifying-risk-factors-for-fear-of-falling-the-international-mobility-in-aging-study-imias
#14
Carmen-Lucia Curcio, Yan Yan Wu, Afshin Vafaei, Juliana Fernandez de Souza Barbosa, Ricardo Guerra, Jack Guralnik, Fernando Gomez
Background: We determine the best combination of factors for predicting the risk of developing fear of falling (FOF) in older people via Classification Regression Tree (CaRT) analysis. Methods: Community-dwelling older adults living in Canada, Albania, Brazil, and Colombia were from International Mobility in Aging Study (IMIAS). In 2014, 1,725 participants (aged 65-74) were assessed. With a retention rate of 81%, in 2016, 1,409 individuals were reassessed. Risk factors for FOF were entered into the CaRT: age, sex, education, self-rated health, comorbidity, medication, visual impairment, frailty, cognitive deficit, depression, fall history, Short Physical Performance Battery (SPPB), walking aid use, and mobility disability measured by the Nagi questionnaire...
February 8, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30753311/association-of-indoor-and-outdoor-air-pollution-with-hand-grip-strength-among-adults-in-six-low-and-middle-income-countries
#15
Hualiang Lin, Yanfei Guo, Zengliang Ruan, Paul Kowal, Qian Di, Yang Zheng, Jianpeng Xiao, Emiel O Hoogendijk, Elsa Dent, Michael G Vaughn, Steven W Howard, Zheng Cao, Wenjun Ma, Zhengmin Min Qian, Fan Wu
Background: Air pollution has been associated with various health outcomes. Its effect on hand-grip strength, a measurement of the construct of muscle strength and health status, remains largely unknown. Methods: We used the survey data from 31,209 adults ≥ 50 years of age within Wave 1 of the Study on Global AGEing and Adult Health in six low- and middle-income countries. The outdoor concentration of fine particulate matter pollution (PM2.5) was estimated using satellite data...
February 7, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30753309/why-sons-hurt-exploring-biological-and-social-mechanisms-influencing-maternal-health
#16
Patricia Thomas, Mieke Thomeer
No abstract text is available yet for this article.
February 7, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30726886/walking-for-better-outcomes-and-recovery-the-effect-of-walk-for-in-preventing-hospital-associated-functional-decline-among-older-adults
#17
Yaniv Cohen, Anna Zisberg, Yehudit Chayat, Nurit Gur-Yaish, Efrat Gil, Chedva Levin, Debbie Rand, Maayan Agmon
Background: In-hospital immobility of older adults is associated with hospital-associated functional decline (HAFD). This study examined the WALK-FOR program's effects on HAFD prevention. Methods: A quasi-experimental pre-post two-group (intervention group [IG] n = 188, control group [CG] n = 189) design was applied in two hospital internal-medical units. On admission, patients reported pre-hospitalization functional status, which was assessed again at discharge and 1-month follow-up...
February 6, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30726878/approaches-to-assessment-of-muscle-mass-and-myosteatosis-on-computed-tomography-ct-a-systematic-review
#18
Behrang Amini, Sean P Boyle, Robert D Boutin, Leon Lenchik
There is increasing use of computed tomography (CT) in sarcopenia research using a wide variety of techniques. We performed a systematic review of the CT literature to identify the differences between approaches used. A comprehensive search of PubMed from 1983-2017 was performed to identify studies that used CT muscle measurements to assess muscle mass and myosteatosis. The CT protocols were evaluated based on: anatomic landmark(s), thresholding, muscle(s) segmented, key measurement (i.e., muscle attenuation, cross-sectional area, volume), derived variables, and analysis software...
February 6, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30721991/tracking-multimorbidity-changes-in-racial-ethnic-diverse-populations-over-time-issues-and-considerations
#19
Ana R Quiñones, Heather G Allore, Anda Botoseneanu, Jason T Newsom, Corey Nagel, David A Dorr
Multimorbidity is widely recognized as having adverse effects on health and wellbeing and may threaten the ability of older adults to live independently. Much of what is known about multimorbidity rests on research that has largely focused on one point-in-time, or from a static perspective. Given that there remains a lack of agreement in the field on how to standardize multimorbidity definitions and measurement, it is not surprising that analyzing and predicting multimorbidity development, progression over time, and its impact are still largely unaddressed...
February 5, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30721985/effect-of-reactive-balance-training-involving-repeated-slips-and-trips-on-balance-recovery-among-older-adults-a-blinded-randomized-controlled-trial
#20
Yoshiro Okubo, Daina L Sturnieks, Matthew A Brodie, Lionne Duran, Stephen R Lord
Background: This study examined whether reactive balance training (exposures to slips and trips) could improve balance recovery and reduce perturbation-induced falls among older adults. Methods: Forty-four community-dwelling older adults participated in a parallel, blinded randomized controlled trial conducted in a research institute in Sydney, Australia in 2017-2018 (ACTRN12617000564358). The intervention group (n=22) underwent three 40-min sessions (total 120 minutes) that exposed them to (1) 20 trips, (2) 20 slips and (3) 10 trips and 10 slips in mixed order, over two days...
February 5, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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