Takuya Takahashi, Takehiro Takahashi, Tetsuya Ikawa, Hitoshi Terui, Toshiya Takahashi, Yuichiro Segawa, Hayakazu Sumida, Ayumi Yoshizaki, Shinichi Sato, Yoshihide Asano
Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, aberrant immune activation, and extensive tissue fibrosis of the skin and internal organs. Because of the complicated nature of its pathogenesis, the underlying mechanisms of SSc remain incompletely understood. Angiogenic factor with a G-patch domain and a Forkhead-associated domain 1 (AGGF1) is a critical factor in angiogenesis expressed on vascular endothelial cells, associated with inflammatory and fibrotic responses. To elucidate the possible implication of AGGF1 in SSc pathogenesis, we investigated the association between serum AGGF1 levels and clinical manifestations in SSc patients...
April 15, 2024: Journal of Dermatology