Zhili Deng, Mengting Chen, Hongfu Xie, Dan Jian, San Xu, Qinqin Peng, Ke Sha, Yingzi Liu, Yiya Zhang, Wei Shi, Ji Li
Rosacea is a chronic inflammatory skin disorder whose pathophysiological mechanism remains largely unknown. Although recent studies have revealed the hypersensitivity of the skin towards chemical, thermal and biological stimuli, there is no direct molecular evidence suggesting the skin barrier is impaired in rosacea. In this study, we demonstrated that the mRNA levels of most claudins (CLDN), the main components of tight junctions determining the major barrier of the paracellular pathway between epithelial cells, were lowered in lesional skin of rosacea patients, especially with erythematotelangiectatic (ETR) and papulopustular (PPR) subtypes...
February 4, 2019: Journal of Dermatology