journal
https://read.qxmd.com/read/38301186/effect-of-lurasidone-on-social-functioning-in-schizophrenia-post-hoc-analysis-of-the-jewel-study
#21
RANDOMIZED CONTROLLED TRIAL
Itaru Miura, Fumiya Sano, Reiko Sakaguchi, Keisuke Okamoto, Hidenori Maruyama
Objective: To evaluate the effects of lurasidone on social functioning in schizophrenia over the course of a 6-week, double-blind, placebo-controlled study and a subsequent 12-week open-label extension study. Methods: A total of 478 patients with schizophrenia (per DSM-IV-TR criteria) randomized to either lurasidone 40 mg/d (n = 245) or placebo (n = 233) in the initial 6-week double-blind study (initiated May 2016, completed November 2018) were included in the analysis. Longer-term changes were examined in a sample of 146 patients who received lurasidone, and 141 who received placebo, during the 6-week study and received flexibly dosed (40-80 mg/d) lurasidone during the 12-week extension phase...
January 31, 2024: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38301185/where-does-lamotrigine-fit-in-the-pharmacotherapy-of-mood-disorders-an-evidence-based-appraisal
#22
JOURNAL ARTICLE
Joseph F Goldberg
No abstract text is available yet for this article.
January 31, 2024: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38301190/physical-exercise-and-health-5-sedentary-time-independent-of-health-related-physical-activity-as-a-risk-factor-for-adverse-physical-health-and-mental-health-outcomes
#23
JOURNAL ARTICLE
Chittaranjan Andrade
Medical and neuropsychiatric benefits associated with physical exercise and activity are well recognized. It is less well known that time spent in sedentary behaviors, such as television-viewing or sitting at a desk, are associated with adverse health outcomes even after taking into consideration health-related physical activity. Although sedentary behaviors have become common in daily life, people tend to substantially underestimate how sedentary they actually are. The average person spends nearly 10 hours per day in a sedentary state, during leisure activities or work; sedentariness is even greater in persons with major mental illness such as psychosis...
January 29, 2024: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38301189/telehealth-collaborative-care-led-by-clinical-pharmacists-for-people-with-psychosis-or-bipolar-disorder-a-propensity-weighted-comparison-with-usual-psychiatric-care
#24
JOURNAL ARTICLE
Esti Iturralde, Lisa Fazzolari, Natalie E Slama, Stacey E Alexeeff, Stacy A Sterling, Sameer Awsare, Maria T Koshy, Macy Shia
Objective: People with psychosis or bipolar disorder (severe and persistent mental illness [SPMI]) are at high risk for poor psychiatric and chronic illness outcomes, which could be ameliorated through improved health care quality. This study assessed whether a telehealth, collaborative care program managed by psychiatric clinical pharmacists (SPMI Population Care) was associated with improved health care quality for adults with SPMI in a large California health system. Methods: This retrospective cohort study used electronic health record data to compare 968 program enrollees at 6 demonstration sites (Population Care) to 8,339 contemporaneous patients with SPMI at 6 non-program sites (Usual Care)...
January 29, 2024: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38270545/the-clinician-s-tardive-inventory-cti-a-new-clinical-tool-for-documenting-and-rating-tardive-dyskinesia
#25
JOURNAL ARTICLE
Richard M Trosch, Cynthia L Comella, Stanley N Caroff, William G Ondo, Alicia C Shillington, Brandon J LaChappelle, Robert A Hauser, Christoph U Correll, Joseph H Friedman
Objective: Current clinician-rated tardive dyskinesia (TD) symptom scales have not addressed the expanding clinical signs and functional impact of TD. The study objective was to develop and test the reliability of a new integrated instrument. Methods: A movement disorder neurologist devised the outline of the rating scale. A Steering Committee (5 neurologists and 2 psychiatrists) provided revisions until consensus was reached. The Clinician's Tardive Inventory (CTI) assesses abnormal movements of the eye/eyelid/face, tongue/mouth, jaw, and limb/trunk; complex movements defined as complicated movements different from simple patterned movements or postures; and vocalizations...
January 24, 2024: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38270549/suicidality-emerging-from-rapid-venlafaxine-discontinuation-a-challenge-dechallenge-rechallenge-case-report
#26
JOURNAL ARTICLE
Milutin Kostic, Martin Plöderl, Michael Hengartner, Jelena Buzejic
No abstract text is available yet for this article.
January 22, 2024: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38270548/relative-risk-of-breast-cancer-associated-with-prolactin-increasing-antipsychotic-use
#27
LETTER
Heidi Taipale, Marco Solmi, Christoph U Correll, Jari Tiihonen
No abstract text is available yet for this article.
January 22, 2024: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38270547/reckoning-risk-retrospectively-reply-to-taipale-et-al
#28
JOURNAL ARTICLE
Chittaranjan Andrade
No abstract text is available yet for this article.
January 22, 2024: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38236048/enriching-the-assessment-of-suicidal-ideation-learning-from-digital-studies
#29
JOURNAL ARTICLE
Philippe Courtet, Enrique Baca-García
No abstract text is available yet for this article.
January 17, 2024: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38236047/cyp2d6-genotyping-and-inhibition-as-predictors-of-adverse-drug-reactions-in-depressive-disorders
#30
JOURNAL ARTICLE
Amanda Holck, Marie Asp, Henrik Green, Åsa Westrin, Margareta Reis
Objective: The primary aim of this study was to examine the association between the different predicted phenotypes of the polymorphic CYP2D6 gene and the prevalence of adverse drug reactions in patients suffering from depressive disorders. The secondary aim was to investigate if comedication with CYP2D6 inhibitors resulted in more adverse drug reactions due to phenoconversion. Methods: Between January 2012 and December 2021, 415 patients with a depressive disorder and insufficient treatment response in secondary psychiatric care were included in the naturalistic observational study Genes, Depression, and Suicidality (GEN-DS)...
January 17, 2024: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38236020/efficacy-and-safety-of-iloperidone-in-bipolar-mania-a-double-blind-placebo-controlled-study
#31
RANDOMIZED CONTROLLED TRIAL
Rosarelis Torres, Emily L Czeisler, Sean R Chadwick, Stephen M Stahl, Sandra P Smieszek, Changfu Xiao, Christos M Polymeropoulos, Gunther Birznieks, Mihael H Polymeropoulos
Objective: To determine if iloperidone, a second-generation antipsychotic, reduces symptoms of bipolar mania. Methods: This phase 3, randomized, double-blind, placebo-controlled study was conducted in adults with bipolar mania at 27 US and international sites between April 2021 and September 2022. Participants were randomized 1:1 to iloperidone (up to 24 mg/d given twice daily) or placebo for 4 weeks. The primary efficacy endpoint was change from baseline to week 4 in Young Mania Rating Scale (YMRS) total score versus placebo...
January 15, 2024: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38206018/testing-for-sleep-disordered-breathing-in-psychiatric-practice-don-t-sleep-on-it
#32
JOURNAL ARTICLE
Barry Krakow
No abstract text is available yet for this article.
January 10, 2024: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38206011/clinical-outcomes-of-intravenous-ketamine-treatment-for-depression-in-the-va-health-system
#33
JOURNAL ARTICLE
Paul N Pfeiffer, Jamarie Geller, Dara Ganoczy, Jennifer Jagusch, John Carty, Fe Erlita D Festin, William S Gilmer, Brian Martis, Mohini Ranganathan, Ilse R Wiechers, Avinash Hosanagar
Objective/Background: Intravenous (IV) ketamine is effective for reducing symptoms of major depressive disorder in short-term clinical trials; this study characterized clinical outcomes of repeated infusions in routine clinical practice and the frequency and number of infusions used to sustain symptom improvement. Methods: Records of IV ketamine infusions for depression and associated Patient Health Questionnaire-9 (PHQ-9) scores were identified from Veterans Health Administration (VA) electronic medical records for patients treated in Fiscal Year 2020 and up to 12 months following the date of their first infusion...
January 8, 2024: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38175947/novel-quality-control-metric-for-the-pharmacotherapy-of-major-depressive-disorder-measuring-guideline-concordance-and-its-impact-on-symptom-severity
#34
JOURNAL ARTICLE
Mason T Breitzig, Fan He, Lan Kong, Guodong Liu, Daniel A Waschbusch, Jeff D Yanosky, Erika F H, Duanping Liao
Objective: Studies suggest that people with major depressive disorder (MDD) often receive treatment that is not concordant with practice guidelines. To evaluate this, we (1) developed a guideline concordance algorithm for MDD pharmacotherapy (GCA-8), (2) scored it using clinical data, and (3) compared its explanation of patient-reported symptom severity to a traditional concordance measure. Methods: This study evaluated 1,403 adults (67% female, 85% non-Hispanic/Latino White, mean age 43 years) with non-psychotic MDD (per ICD-10 codes), from the Penn State Psychiatry Clinical Assessment and Rating Evaluation System (PCARES) registry (visits from February 1, 2015, to April 13, 2021)...
January 3, 2024: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38175946/factors-associated-with-oral-anticoagulant-use-in-patients-with-atrial-fibrillation-and-mental-disorders
#35
JOURNAL ARTICLE
Dina Farran, Matthew Broadbent, Aikaterini Dima, Mark Ashworth, Fiona Gaughran
Objective: This study aims to identify how mental illness severity interacts with oral anticoagulant (OAC) patterns among people with atrial fibrillation (AF). Methods: AF patients with comorbid mental illness (classified using ICD-10 ) were identified from the South London and Maudsley Biomedical Research Centre Case Register. CHA2 DS2 -VASc and ORBIT scales were used to calculate stroke and bleeding risks, respectively, whereas Health of the Nation Outcome Scales (HoNOS) assessment was used for functional impairment...
January 3, 2024: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38153320/long-term-safety-and-efficacy-of-initial-and-repeat-treatment-courses-with-zuranolone-in-adult-patients-with-major-depressive-disorder-interim-results-from-the-open-label-phase-3-shoreline-study
#36
JOURNAL ARTICLE
Andrew J Cutler, Gregory W Mattingly, Susan G Kornstein, Scott T Aaronson, Robert Lasser, Hongling Zhang, Nilanjana Rana, Colville Brown, Seth Levin, Catherine Miller, Mona Kotecha, Fiona Forrestal, James Doherty
Objective: Zuranolone is a positive allosteric modulator of both synaptic and extrasynaptic γ-aminobutyric acid (GABA) type A receptors and a neuroactive steroid approved in the United States as an oral, once-daily, 14-day treatment course for adults with postpartum depression and under investigation for adults with major depressive disorder (MDD). Interim results from the open-label, longitudinal, phase 3 SHORELINE Study (NCT03864614) that evaluated the long-term safety and efficacy of zuranolone in adults with MDD are reported...
December 27, 2023: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38153319/magnitude-and-correlates-of-symptomatic-global-illness-and-social-functioning-response-out-of-home-placement-and-length-of-stay-in-1-189-consecutively-hospitalized-children-and-adolescents-with-mental-disorders
#37
JOURNAL ARTICLE
Viktor B Nöhles, Charlotte Jaite, Kerstin Rubarth, Fabiola H Heuer, Katja Bödeker, Laura Golz, Sibylle M Winter, Christoph U Correll
Objective: To identify outcome predictors in hospitalized youth with mental disorders. Methods: This retrospective analysis of systematically recorded clinical parameters in youth hospitalized for psychiatric treatment in 2004-2015 assessed magnitude and correlates of symptom response (SR), global illness response (GIR), social functioning (SF), out-of-home placement (OOHP), and length of stay (LOS). Backward elimination regression analyses were performed to identify independent baseline correlates of each of the 5 outcomes, with R 2 representing the variance explained by the independent correlates retained in the final model...
December 27, 2023: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38127310/the-effectiveness-of-metformin-in-managing-second-generation-antipsychotic-induced-weight-gain-in-children-and-adolescents
#38
JOURNAL ARTICLE
Hua Chen, Ning Lyu, Chadi Calarge, Austin De La Cruz, Wenyaw Chan
Objective: This study aimed to assess the effectiveness of metformin for antipsychotic-induced weight gain (AIWG) and determine whether the timing of metformin initiation and premorbid obesity moderated metformin effectiveness in children and adolescents on treatment with second-generation antipsychotics (SGAs). Methods: A cohort of individuals 6 to 17 years of age, from 2016 to 2021, initiating a new SGA treatment and receiving a subsequent metformin prescription during SGA treatment were identified from the IQVIA Ambulatory EMR-US database...
December 20, 2023: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38127311/a-comparison-of-depressive-symptom-self-reported-measures-in-the-texas-youth-depression-and-suicide-research-network-tx-ydsrn
#39
JOURNAL ARTICLE
Karabi Nandy, A John Rush, Thomas Carmody, Beth D Kennard, Graham J Emslie, Holli Slater, Taryn L Mayes, Melissa DeFilippis, Cynthia Garza, Eric A Storch, Sarah M Wakefield, Madhukar H Trivedi
Objective: To evaluate psychometrically and provide crosswalks between 3 self-report measures of depressive symptomatology in youth in psychiatric care settings. Ratings included the Patient Health Questionnaire for Adolescents (PHQ-A), a widely used 9-item self-report; the 16-item Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR16 ); and the 5-item Very Quick Inventory of Depressive Symptomatology-Self-Report (VQIDS-SR5 ), a recent effort to create a bridge from the QIDS-SR16 to clinical practice...
December 18, 2023: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38127306/the-intense-psychological-burden-of-als-the-enduring-strength-of-people-living-with-als-and-the-tools-we-can-use-to-help
#40
JOURNAL ARTICLE
Doreen T Ho, James D Berry
No abstract text is available yet for this article.
December 13, 2023: Journal of Clinical Psychiatry
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