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Journals Journal of Clinical Endocrinol...

Journal of Clinical Endocrinology and Metabolism

https://read.qxmd.com/read/38815053/circulating-micrornas-as-predictors-of-beta-cell-function-in-youth-onset-type-2-diabetes-the-today-study
#41
JOURNAL ARTICLE
Dakota Redling, Shannon Bialak, Laure El Ghormli, Steven D Chernausek, Kenneth Jones, Jeanie B Tryggestad
AIMS: In the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study, an intervention trial followed by an observational phase, half the participants reached the primary outcome (HbA1c ≥ 8% for at least 6 months) within 4 years which was associated with a decrease in C-peptide oral disposition index (oDI). We aimed to identify circulating miRNA species associated with decline in beta cell function. METHODS: Following a preliminary survey of select participants using nCounter Human v3 miRNA Panel (NanoString Technologies), polymerase chain reaction analyses were carried out for 17 miRNAs from 365 participants from samples at baseline, 24, 60, 96, and 120 months...
May 30, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38815002/association-between-gender-affirming-hormone-therapy-and-measures-of-glucose-metabolism-a-longitudinal-study
#42
JOURNAL ARTICLE
Olivia Anike, Qi Zhang, Shalender Bhasin, W Dana Flanders, Darios Getahun, J Sonya Haw, Krista F Huybrechts, Timothy L Lash, Courtney E McCracken, Douglas Roblin, Michael J Silverberg, Shakira F Suglia, Vin Tangpricha, Suma Vupputuri, Michael Goodman
CONTEXT: The long-term effect of gender-affirming hormone therapy (GAHT) on glucose metabolism is an area of priority in transgender health research. OBJECTIVES: To evaluate the relation between GAHT and changes in fasting blood glucose (FG) and glycosylated hemoglobin (HbA1c) in transmasculine (TM) and transfeminine (TF) persons relative to the corresponding temporal changes in presumably cisgender persons (i.e. without any evidence of TGD status). DESIGN: Retrospective cohort study...
May 30, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38809769/response-to-letter-to-the-editor-from-rosenfield-et-al-recommendations-from-the-2023-international-evidence-based-guideline-for-the-assessment-and-management-of-polycystic-ovary-syndrome
#43
JOURNAL ARTICLE
Helena Teede, Chau Tay, Ricardo Azziz
No abstract text is available yet for this article.
May 29, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38809759/letter-to-the-editor-from-rosenfield-et-al-recommendations-from-the-2023-international-evidence-based-guideline-for-the-assessment-and-management-of-polycystic-ovary-syndrome
#44
JOURNAL ARTICLE
Robert L Rosenfield, Kathryn A Martin, R Jeffrey Chang, David A Ehrmann, Rogerio A Lobo, Michel M Pugeat
No abstract text is available yet for this article.
May 29, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38805186/metabolic-profiles-of-offspring-born-from-biopsied-embryos-from-toddlerhood-to-preschool-age
#45
JOURNAL ARTICLE
Jialin Zhao, Shuo Li, Miaomiao Ban, Shuzhe Gao, Linlin Cui, Junhao Yan, Xiaohe Yang, Jincheng Li, Yiyuan Zhang, Shengnan Guan, Wei Zhou, Xuan Gao, Zi-Jiang Chen
CONTEXT: Embryo biopsy, which is necessary for preimplantation genetic testing (PGT), has not been fully investigated regarding its potential influences and safety. Previous studies of children born from biopsied embryos (PGT children) have primarily centered around their growth and neuropsychological development, while there remains limited knowledge concerning their endocrine and metabolic parameters. OBJECTIVE: This study aims to examine the effect of trophectoderm (TE) biopsy on metabolic outcomes for PGT children...
May 28, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38801675/letter-to-the-editor-from-xie-et-al-the-13c-glucose-breath-test-accurately-identifies-insulin-resistance-in-people-with-type-1-diabetes
#46
JOURNAL ARTICLE
Cong Xie, Weikun Huang, Christopher K Rayner, Michael Horowitz, Tongzhi Wu
No abstract text is available yet for this article.
May 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38801670/fgf21-mediating-sex-dependent-response-to-dietary-macronutrients
#47
JOURNAL ARTICLE
Karla A Soto Sauza, Karen K Ryan
Sex is key variable influencing body composition and substrate utilization. At rest, females maintain greater adiposity than males and resist the mobilization of fat. Males maintain greater lean muscle mass and mobilize fat readily. Determining the mechanisms that direct these sex-dependent effects is important for both reproductive and metabolic health. Here we highlight the fundamental importance of sex in shaping metabolic physiology and assess growing evidence that the hepatokine Fibroblast growth factor-21 (FGF21) plays a mechanistic role to facilitate sex-dependent responses to a changing nutritional environment...
May 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38801437/prognostic-analysis-of-131i-efficacy-after-papillary-thyroid-carcinoma-surgery-based-on-ct-radiomics
#48
JOURNAL ARTICLE
Huijun Cao, Linjue Shangguan, Hanlin Zhu, Chunfeng Hu, Tong Zhang, Zhijiang Han, Peiying Wei
OBJECTIVE: To develop and validate a radiomics-clinical combined model combining preoperative CT and clinical data from patients with papillary thyroid carcinoma (PTC) to predict the efficacy of initial postoperative 131I treatment. METHODS: A total of 181 patients with PTC who received total thyroidectomy and initial 131I treatment were divided into training and testing sets (7:3 ratio). Univariate analysis and multivariate logistic regression were used to screen clinical factors affecting the therapeutic response to 131I treatment and construct a clinical model...
May 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38795393/effects-of-tirzepatide-vs-semaglutide-on-%C3%AE-cell-function-insulin-sensitivity-and-glucose-control-during-a-meal-test
#49
JOURNAL ARTICLE
Kieren J Mather, Andrea Mari, Tim Heise, J Hans DeVries, Ming Hua, Shweta Urva, Tamer Coskun, Axel Haupt, Robert J Heine, Edward Pratt, Melissa K Thomas, Zvonko Milicevic
CONTEXT: In a clinical study, tirzepatide, a glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonist (GIP/GLP-1RA), provided superior glycemic control vs the GLP-1RA semaglutide. The physiologic mechanisms are incompletely understood. OBJECTIVE: To evaluate treatment effects by model-based analyses of mixed-meal tolerance test (MMTT) data. DESIGN: A 28-week double-blind, randomized, placebo-controlled trial. SETTING: Two clinical research centers in Germany...
May 26, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38795366/low-bone-mineral-density-as-a-predictor-of-mortality-and-infections-in-stroke-patients-a-hospital-based-study
#50
JOURNAL ARTICLE
Yu-Lin Tsai, Ya-Chi Chuang, Yuan-Yang Cheng, Ya-Lian Deng, Shih-Yi Lin, Chun-Sheng Hsu
CONTEXT: Low bone mineral density (BMD) has been linked to elevated risks of mortality and infections in the general population; however, its association with these outcomes in stroke patients remains unclear. OBJECTIVE: This study aims to investigate the correlation between low BMD and risks of mortality and infections among stroke patients in a Taiwanese cohort. METHODS: In this single-centered retrospective cohort study, 905 stroke patients from a Taiwanese database (2000-2022) were analyzed...
May 25, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38783717/multicenter-analysis-of-cardiometabolic-related-diagnoses-in-youth-with-congenital-adrenal-hyperplasia-a-pedsnet-study
#51
JOURNAL ARTICLE
Li-Min Chen, Anna Valentine, Shanlee M Davis, Evan Graber, Patricia Y Fechner, Anna Furniss, Leena Nahata, Laura Pyle, Arpita K Vyas, Maria G Vogiatzi, Natalie J Nokoff
CONTEXT: Small cohorts of youth with congenital adrenal hyperplasia (CAH) demonstrate increased risk of obesity and poor cardiometabolic health. OBJECTIVE: To determine the odds of cardiometabolic-related diagnoses in youth with CAH compared to matched controls in a cross-sectional analysis in a large, multisite database (PEDSnet). DESIGN: Electronic health record data (2009-2019) were used to determine odds of cardiometabolic-related outcomes based on diagnosis, anthropometric and laboratory data using logistic regression among youth with CAH vs...
May 24, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38781538/maternal-thyroid-function-in-early-pregnancy-and-offspring-school-performance-and-neurodevelopmental-disorders
#52
JOURNAL ARTICLE
Line Tang Møllehave, Mia Klinten Grand, Margit Kriegbaum, Christen Lykkegaard Andersen, Bent Struer Lind, Nicolien Alien van Vliet, Diana van Heemst, Katrine Strandberg-Larsen
CONTEXT: Thyroid hormones are critical for neural development, and during the first trimester of pregnancy the fetus relies fully on maternal thyroid hormone production. OBJECTIVE: To investigate the associations between maternal thyroid hormone levels in the first trimester with the child's school performance, risk of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). METHODS: From the Copenhagen Primary Care Laboratory Pregnancy Database information on first trimester TSH and fT4 measurements in mothers of children born in 2000-2014 were linked with information on the child's standardized test scores in school, ADHD (patient record diagnoses and medication) and ASD (patient record diagnoses) until end of 2018...
May 24, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38781537/phenylbutyrate-treatment-in-a-boy-with-mct8-deficiency-improvement-of-thyroid-function-tests-and-possible-livertoxicity
#53
JOURNAL ARTICLE
Felix Schreiner, Heike Vollbach, Niklas Sonntag, Vera Schempp, Bettina Gohlke, Johannes Friese, Joachim Woelfle, Doreen Braun, Ulrich Schweizer
CONTEXT: Monocarboxylate transporter 8 (MCT8) deficiency is a rare X-chromosomal inherited disease leading to severe cognitive impairment, muscular hypotonia and symptoms of peripheral thyrotoxicosis. Experimental approaches aiming to functionally rescue mutant MCT8 activity by the chemical chaperone phenylbutyrate (PB) demonstrated promising effects in vitro for several MCT8 missense mutations. OBJECTIVE: The objective was to evaluate biochemical and clinical effects of PB in doses equivalent to those approved for the treatment of urea cycle disorders in a boy with MCT8 deficiency due to a novel MCT8 missense mutation c...
May 24, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38780990/correction-to-dose-dependent-association-of-alcohol-consumption-with-obesity-and-type-2-diabetes-mendelian-randomization-analyses
#54
(no author information available yet)
No abstract text is available yet for this article.
May 23, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38780968/tsh-trajectories-during-levothyroxine-treatment-in-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil-cohort
#55
JOURNAL ARTICLE
Matthew D Ettleson, Gustavo C E Penna, Wen Wan, Isabela M Benseñor, Neda Laiteerapong, Antonio C Bianco
CONTEXT: Thyroid-stimulating hormone (TSH) trajectory classification represents a novel approach to defining the adequacy of levothyroxine (LT4) treatment for hypothyroidism over time. OBJECTIVE: This is a proof of principle study that uses longitudinal clinical data, including thyroid hormone levels from a large prospective study to define classes of TSH trajectories and examine changes in cardiovascular (CV) health markers over the study period. METHODS: Growth mixture modeling (GMM), including latent class growth analysis (LCGA), was used to classify LT4-treated individuals participating in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) based on serial TSH levels...
May 23, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38779881/a-prospective-study-of-publicly-funded-molecular-testing-of-indeterminate-thyroid-nodules-canada-s-experience
#56
JOURNAL ARTICLE
Florence Lévesque, Richard J Payne, Danielle Beaudoin, Andrée Boucher, Pierre-Hugues Fortier, Marie-Hélène Massicotte, Marc Pusztaszeri, Geneviève Rondeau, Edith Corriveau, Farida El Malt, Maryse Brassard
CONTEXT: Indeterminate thyroid nodules (ITNs) lead to diagnostic surgeries in many countries. Use of molecular testing (MT) is endorsed by several guidelines, but costs are limitative, especially in public healthcare systems like in Canada. OBJECTIVES: Primary objective: evaluate the clinical value of Thyroseq® v3 (TSv3) using benign call rate (BCR) in a real-world practice. Secondary objective: assess cost-effectiveness of MT. DESIGN: This is a multicentric prospective study...
May 23, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38779872/characterising-24-h-skeletal-muscle-gene-expression-alongside-metabolic-endocrine-responses-under-diurnal-conditions
#57
JOURNAL ARTICLE
Harry A Smith, Iain Templeman, Max Davis, Tommy Slater, David J Clayton, Ian Varley, Lewis J James, Benita Middleton, Jonathan D Johnston, Leonidas G Karagounis, Kostas Tsintzas, Dylan Thompson, Javier T Gonzalez, Jean-Philippe Walhin, James A Betts
CONTEXT: Skeletal muscle plays a central role in the storage, synthesis, and breakdown of nutrients, yet little research has explored temporal responses of this human tissue, especially with concurrent measures of systemic biomarkers of metabolism. OBJECTIVE: To characterise temporal profiles in skeletal muscle expression of genes involved in carbohydrate metabolism, lipid metabolism, circadian clocks, and autophagy and descriptively relate them to systemic metabolites and hormones during a controlled laboratory protocol...
May 23, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38779861/letter-to-the-editor-from-de-zegher-and-ib%C3%A3-%C3%A3-ez-metformin-and-combined-oral-contraceptive-pills-in-the-management-of-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis
#58
EDITORIAL
Francis de Zegher, Lourdes Ibáñez
No abstract text is available yet for this article.
May 23, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38776236/all-three-in-one-it-s-a-cohort-proteomics-and-mendelian-randomization-biomarker-study
#59
EDITORIAL
Jun Wada
No abstract text is available yet for this article.
May 22, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38776231/the-effect-of-thiazide-diuretics-on-urinary-prostaglandin-e2-excretion-and-serum-sodium-in-the-general-population
#60
JOURNAL ARTICLE
Frank Geurts, Crissy F Rudolphi, Anissa Pelouto, Anna C van der Burgh, Mahdi Salih, Pedro Henrique Imenez Silva, Robert A Fenton, Layal Chaker, Ewout J Hoorn
CONTEXT: Thiazide-induced hyponatremia is one of the most common forms of hyponatremia, but its pathogenesis is incompletely understood. Recent clinical data suggest links with prostaglandin E2 (PGE2) and a single nucleotide polymorphism (SNP) in the prostaglandin transporter gene (SLCO2A1), but it is unknown if these findings also apply to the general population. OBJECTIVE: To study the associations between serum sodium, thiazide diuretics, urinary excretions of PGE2 and its metabolite (PGEM), and the rs34550074 SNP in SLCO2A1 in the general population...
May 22, 2024: Journal of Clinical Endocrinology and Metabolism
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