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Journal of Child and Adolescent Psychopharmacology

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https://read.qxmd.com/read/30758986/retrospective-analysis-of-the-effectiveness-and-tolerability-of-long-acting-paliperidone-palmitate-antipsychotic-in-adolescent-first-episode-schizophrenia-patients
#1
Daniela Petrić, Valentino Rački, Nadija Gačo, Ana Kaštelan, Mirjana Graovac
OBJECTIVE: The aim of this study was to explore the effectiveness and tolerability of long-acting paliperidone palmitate antipsychotic in adolescent first-episode schizophrenia patients while comparing the results with the oral antipsychotic risperidone. METHODS: This study is a retrospective, noninterventional study to assess the effectiveness and tolerability of long-acting injectable antipsychotic paliperidone palmitate in first-episode adolescent patients during the first 12 months of treatment compared with the oral antipsychotic risperidone...
February 13, 2019: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30741567/crocus-sativus-l-versus-methylphenidate-in-treatment-of-children-with-attention-deficit-hyperactivity-disorder-a-randomized-double-blind-pilot-study
#2
Sara Baziar, Ali Aqamolaei, Ebrahim Khadem, Seyyed Hosein Mortazavi, Sina Naderi, Erfan Sahebolzamani, Amirhosein Mortezaei, Shakiba Jalilevand, Mohammad-Reza Mohammadi, Mahsa Shahmirzadi, Shahin Akhondzadeh
OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neuropsychiatric disorders of childhood and adolescence. About 30% of patients do not respond to stimulants or cannot tolerate their side effects. Thus, alternative medication, like herbal medicine, should be considered. The aim of this trial is to compare the safety and efficacy of Crocus sativus (saffron) versus methylphenidate in improving symptoms of children with ADHD. METHODS: In a 6-week randomized double-blind study, 54 patients (children 6-17 years old) with a Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnosis of ADHD were randomly assigned to receive either 20-30 mg/d (20 mg/d for <30 kg and 30 mg/d for >30 kg) methylphenidate (MPH) or 20-30 mg/d saffron capsules depending on weight (20 mg/d for <30 kg and 30 mg/d for >30 kg)...
February 11, 2019: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30724590/guanfacine-extended-release-for-the-reduction-of-aggression-attention-deficit-hyperactivity-disorder-symptoms-and-self-injurious-behavior-in-prader-willi-syndrome-a-retrospective-cohort-study
#3
Deepan Singh, Yuji Wakimoto, Carole Filangieri, Aaron Pinkhasov, Moris Angulo
OBJECTIVE: To examine the role of Guanfacine Extended Release (GXR) in the management of behavioral disturbances in patients with Prader-Willi Syndrome (PWS). METHODS: Twenty from a total of 27 individuals with genetically confirmed PWS, 6-26 years of age, with the following symptoms were identified: significant aggression/agitation, skin picking, and/or symptoms of attention-deficit/hyperactivity disorder (ADHD). Response to GXR for the above noted symptoms was categorized as improved, worsened, or unchanged, while assessing for side effects and tolerability...
February 6, 2019: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30724577/pandas-and-pans-clinical-neuropsychological-and-biological-characterization-of-a-monocentric-series-of-patients-and-proposal-for-a-diagnostic-protocol
#4
Alessandra Gamucci, Sara Uccella, Lucia Sciarretta, Maria D'Apruzzo, Maria Grazia Calevo, Maria Margherita Mancardi, Edvige Veneselli, Elisa De Grandis
OBJECTIVES: Whether PANS (pediatric acute-onset neuropsychiatric syndrome) and PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection) represent true clinical entities is debated and data for a characteristic phenotype are still controversial. In this study, we aim to characterize clinical, neuropsychological, and biochemical aspects in a sample of PANS and PANDAS patients. METHODS: Patients fulfilling a clinical diagnosis of PANS or PANDAS from 2014 to 2017 were enrolled...
February 6, 2019: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30724573/rating-of-the-effectiveness-of-26-psychiatric-and-seizure-medications-for-autism-spectrum-disorder-results-of-a-national-survey
#5
Devon M Coleman, James B Adams, Amy L Anderson, Richard E Frye
OBJECTIVE: The objective of this study was to provide an evaluation of the benefits and adverse effects (AEs) of psychiatric and seizure medications commonly used for individuals with autism spectrum disorder (ASD). METHODS: As part of the National Survey on Treatment Effectiveness for Autism, we report ratings of 26 psychiatric and seizure medications by 505 participants. Each medication was rated with a standardized scale for overall benefits, overall AEs, and specific symptoms affected...
February 6, 2019: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30714820/a-quantitative-comparison-approach-for-methylphenidate-drug-regimens-in-attention-deficit-hyperactivity-disorder-treatment
#6
Sara Soufsaf, Philippe Robaey, Guillaume Bonnefois, Fahima Nekka, Jun Li
OBJECTIVE: Different methylphenidate (MPH) formulations, immediate release (IR) or extended release (ER), have been developed to treat Attention-Deficit/Hyperactivity Disorder (ADHD). A better use of these formulations, with a proper choice of their timing, dosage, and combination, can help to attain optimal therapeutic effect while maintaining a good quality of life. In this study, we aim at presenting a quantitative comparison approach to help identify drug regimens that provide best therapeutic performances and respect patients' specific needs...
February 4, 2019: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30707602/atypical-antipsychotics-for-irritability-in-pediatric-autism-a-systematic-review-and-network-meta-analysis
#7
Merrick S Fallah, Mateen R Shaikh, Binod Neupane, Daniel Rusiecki, Teresa A Bennett, Joseph Beyene
OBJECTIVE: Irritability is common in pediatric autism spectrum disorder (ASD) patients. This can have major implications in child development, receptivity to behavioral therapy, as well as child and caregiver well-being. A systematic review and network meta-analysis were conducted to assess the efficacy and safety of atypical antipsychotics in treating irritability in these patients. METHODS: Studies were identified from Medline, Embase, and PsycINFO from inception to March 2018...
February 1, 2019: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30694697/dasotraline-in-children-with-attention-deficit-hyperactivity-disorder-a-six-week-placebo-controlled-fixed-dose-trial
#8
Robert L Findling, Lenard A Adler, Thomas J Spencer, Robert Goldman, Seth C Hopkins, Kenneth S Koblan, Justine Kent, Jay Hsu, Antony Loebel
OBJECTIVE: Dasotraline is a potent inhibitor of presynaptic dopamine and norepinephrine reuptake with a pharmacokinetic profile characterized by slow absorption and a long elimination half-life. The aim of this study was to evaluate the efficacy and safety of dasotraline in children with attention-deficit/hyperactivity disorder (ADHD). METHODS: Children aged 6-12 years with a Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnosis of ADHD were randomized to 6 weeks of double-blind once-daily treatment with dasotraline (2 or 4 mg) or placebo...
January 29, 2019: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30676073/reported-adverse-drug-reactions-in-children-and-adolescents-treated-with-antipsychotics
#9
Lenneke Minjon, Els van den Ban, Emma de Jong, Patrick C Souverein, Toine C G Egberts, Eibert R Heerdink
OBJECTIVES: To characterize reported adverse drug reactions (ADRs) in children and adolescents treated with antipsychotics and determine differences in relative reporting frequency between genders, age classes, and reporter types. METHODS: Individual case safety reports of children ages 1 - 17 years in whom an antipsychotic drug was the suspected or interacting drug from the worldwide database, VigiBase, from 1968 until March 2017, were included. Reported ADRs were categorized based on the Standardized Medical Dictionary for Regulatory Activities (MedDRA) Queries and clinical reasoning...
January 24, 2019: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30672720/no-differences-in-weight-gain-between-risperidone-and-aripiprazole-in-children-and-adolescents-after-12-months
#10
Renate J Schoemakers, Charlotte van Kesteren, Joost van Rosmalen, Mart L J M Eussen, Hetty G Dieleman, Marieke M Beex-Oosterhuis
BACKGROUND: Weight gain due to the use of second-generation antipsychotics is a major health care issue for adult and paediatric psychiatric patients. Little is known about long-term weight gain effects of aripiprazole compared to risperidone in children and adolescents. OBJECTIVE: The primary aim of this study is to assess whether risperidone and aripiprazole are associated with different weight changes in children and adolescents during the first 12 months of treatment...
January 23, 2019: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30615472/exfoliative-skin-reactions-with-methylphenidate-and-desensitization-procedures-in-two-cases
#11
Yagmur Karakus, Tuna Cak Esen
No abstract text is available yet for this article.
January 7, 2019: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30592635/attendance-and-engagement-in-parent-training-predict-child-behavioral-outcomes-in-children-pharmacologically-treated-for-attention-deficit-hyperactivity-disorder-and-severe-aggression
#12
Heather M Joseph, Cristan Farmer, Heidi Kipp, David Kolko, Michael Aman, James McGinley, L Eugene Arnold, Kenneth D Gadow, Robert L Findling, Brooke S G Molina
OBJECTIVES: We examined the association of parent training (PT)-related factors with therapeutic success in the Treatment of Severe Childhood Aggression (TOSCA) study. Our aims were (1) to evaluate demographic and clinical characteristics as predictors of parent attendance and engagement in PT and (2) to examine the associations of parent attendance and engagement in PT with study-targeted child behavior outcomes (i.e., attention-deficit/hyperactivity disorder [ADHD] and disruptive behavior symptoms)...
December 28, 2018: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30585735/correction-to-intravenous-ketamine-for-adolescents-with-treatment-resistant-depression-an-open-label-study-by-cullen-kr-amatya-p-roback-mg-albott-cs-westlund-schreiner-m-ren-y-eberly-le-carstedt-p-samikoglu-a-gunlicks-stoessel-m-reigstad-k-horek-n-tye-s-lim
#13
https://read.qxmd.com/read/30575416/testicular-function-after-long-term-methylphenidate-treatment-in-boys-with-attention-deficit-hyperactivity-disorder
#14
Liang-Jen Wang, Sheng-Yu Lee, Wen-Jiun Chou, Min-Jing Lee, Ching-Shu Tsai, Tung-Liang Lee, Chun-Ju Yang, Kang-Chung Yang, Chih-Ken Chen, Yu-Chiau Shyu
OBJECTIVE: Treating attention-deficit/hyperactivity disorder (ADHD) with methylphenidate (MPH) has become increasingly common, while both animal studies and case reports have previously suggested that MPH may exert adverse effects on the reproductive system or gonadal hormones. This study aims to investigate whether long-term MPH treatment of boys with ADHD can induce testicular dysfunction (TD). METHODS: A nationwide cohort that included 59,746 boys diagnosed with ADHD and 52,008 healthy subjects retrieved from the National Health Insurance database in Taiwan was also observed between 1999 and 2011...
December 21, 2018: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30575411/oromandibular-dystonia-related-to-sertraline-treatment-in-a-child
#15
Meryem Ozlem Kutuk, Gülen Güler Aksu, Ali Evren Tufan, Tamer Celik
In children, similar to adults, the agents that cause movement disorders are most commonly dopaminergic and antidopaminergic drugs. However, it is also known that selective serotonin reuptake inhibitors (SSRIs), which are frequently prescribed in child psychiatry practice, may rarely lead to tremor, akathisia, dystonia, dyskinesia, and parkinsonism. In this study, we report a rare side effect of SSRIs, namely oromandibular dystonia related to sertraline, in a pediatric patient who was diagnosed with posttraumatic stress disorder...
December 21, 2018: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30575407/early-onset-efficacy-and-safety-pilot-study-of-amphetamine-extended-release-oral-suspension-in-the-treatment-of-children-with-attention-deficit-hyperactivity-disorder
#16
Ann C Childress, Judith C Kando, Thomas R King, Antonio Pardo, Barry K Herman
OBJECTIVE: To determine whether amphetamine extended-release oral suspension (AMPH EROS) has an onset of effect at 30 minutes postdose in children with attention-deficit/hyperactivity disorder (ADHD). METHODS: This randomized, double-blind, two-treatment, two-sequence, placebo-controlled crossover pilot study enrolled subjects aged 6-12 years with ADHD and ADHD-Rating Scale-5 scores of ≥90th percentile for sex and age. An optimized dose of 5-20 mg/day of AMPH EROS was determined during a 1-week open-label dose optimization phase based on medication history, symptom control, and tolerability...
December 21, 2018: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30575406/methylphenidate-induced-nocturnal-bruxism-alleviated-by-adjunctive-clonidine
#17
Ahmed Naguy, Dalal Elsori, Bibi Alamiri
Stimulants-related bruxism has been previously reported; both diurnal and nocturnal. Here, authors report on a case of methylphenidate (MPH)-treated attention-deficit/hyperactivity disorder that developed nocturnal bruxism and failed multiple pharmacologic trials. Add-on clonidine has successfully helped with bruxisms while augmenting MPH response. This was achieved with great tolerability. This remains a viable option to deploy in such unusual clinical scenarios.
December 21, 2018: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30565956/psychotherapy-claims-surrounding-pharmacotherapy-initiation-in-children-and-adolescents-with-anxiety-disorders
#18
Greta A Bushnell, Stacie B Dusetzina, Scott N Compton, Bradley N Gaynes, M Alan Brookhart, Til Stürmer
OBJECTIVES: Psychotherapy is an effective, recommended treatment for pediatric anxiety disorders. Nevertheless, individuals with mental health conditions often do not receive psychotherapy, with variation across provider types. This study sought to examine psychotherapy claims surrounding medication initiation in U.S. children with diagnosed anxiety disorders. METHODS: The study cohort included privately insured children (3-17 years) with a diagnosed anxiety disorder initiating a medication to treat anxiety from 2004 to 2014...
December 19, 2018: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30508385/prevalence-and-predictors-of-medication-use-in-children-with-attention-deficit-hyperactivity-disorder-evidence-from-a-community-based-longitudinal-study
#19
Daryl Efron, Alisha Gulenc, Emma Sciberras, Obioha C Ukoumunne, Philip Hazell, Vicki Anderson, Timothy J Silk, Jan M Nicholson
OBJECTIVES: To determine, in a community-based sample of primary school-aged children meeting diagnostic criteria for attention-deficit/hyperactivity disorder (ADHD), (1) the proportion of children with ADHD treated with medication; (2) predictors of medication use; and (3) the association between medication use and psychological service utilization. METHODS: Grade 1 children with ADHD were recruited through 43 schools in Melbourne, Australia, using a two-stage screening and case confirmation procedure...
December 1, 2018: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/30681386/from-the-editor-in-chief-s-desk
#20
Harold S Koplewicz
No abstract text is available yet for this article.
February 2019: Journal of Child and Adolescent Psychopharmacology
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