Gaojie Qu, Yulu Liu, Jieyuan Ouyang, Linlin Xiao, Xin Liu
OBJECTIVES: To investigate the effects of myelin- and lymphocyte-associated protein (MAL) gene knockout on the morphological structure of lung tissue and the expression of E-cadherin (E-cad) and alpha-smooth muscle actin (α-SMA) in an asthmatic mouse model. METHODS: Twenty-four specific pathogen-free (SPF) C57BL/6J mice were divided into four groups: the wild-type normal (WT/SAL), wild-type asthmatic (WT/OVA), gene knockout normal (MAL-/- /SAL), and gene knockout asthmatic (MAL-/- /OVA) groups...
June 14, 2024: Journal of Asthma
Matteo Bonini, Simona Barbaglia, Gianna Camiciottoli, Stefano Del Giacco, Fabiano Di Marco, Andrea Matucci, Claudio Micheletto, Alberto Papi, Patrizio Pasqualetti, Girolamo Pelaia, Fabio Luigi Massimo Ricciardolo, Paola Rogliani, Gianenrico Senna, Massimo Triggiani, Carlo Vancheri, Giorgio Walter Canonica
OBJECTIVE: Achieving remission in severe asthma holds paramount importance in elevating patient quality of life and reducing both individual and societal burdens associated with this chronic condition. This study centres on identifying pivotal patient-relevant endpoints through standardized, reproducible methods, while also developing a patient-centric definition of remission, essential for effective disease management. METHODS: A discrete choice experiment (DCE) was conducted to assess patients' perceptions on the four primary criteria for defining severe asthma remission, as outlined by the SANI survey...
June 13, 2024: Journal of Asthma
Yanhua Lv, Sudan Gan, Zemin Chen, Tian Luo, Changyun Yang, Lin Fu, Liqin Lin, Lihong Yao, Haixiong Tang
Down-regulation of bronchial epithelial E-cadherin is an important of feature of severe asthma, including steroid-insensitive asthma. Yet, the mechanisms involved in E-cadherin disruption are not fully understood. This study was aimed to investigate the role of glucose transporter 1 (GLUT1) in dysregulation of E-cadherin in toluene diisocyanate (TDI)-induced steroid-insensitive asthma. A murine model of steroid-insensitive asthma was established by TDI sensitization and aerosol inhalation. Selective GLUT1 antagonists WZB117 and BAY876 were given to BALB/c mice after airway challenge...
June 12, 2024: Journal of Asthma
Jiang-Bo Liu, Xue-Jiao Qian, Yu Wu, Xue-Yan Jie, Ping Jiang
OBJECTIVE: We analyzed the impact of different inhalant allergens on T-lymphocyte subsets in patients diagnosed with bronchial asthma. METHODS: The study included 57 bronchial asthma patients and 22 healthy controls. Asthma patients were categorized into dust mite, animal hair, pollen, and mold groups. Flow cytometry was used to measure the cells in the case group and control group. These T-lymphocyte subset markers were evaluated among patients with bronchial asthma caused by different allergens as well as between the case group and control group...
June 11, 2024: Journal of Asthma
Miso Park, Mi Ah Han, Jong Park, Seong Woo Choi
OBJECTIVE: The daily lives of adolescents have changed significantly because of COVID-19 pandemic. We investigated the effects of changes in daily life attributed to COVID-19 on allergic diseases among Korean adolescents. METHODS: Data from the 2021 Korea Youth Risk Behavior Survey were used. In total, 54,848 survey participants were included in the analysis. Allergic diseases included allergic rhinitis, atopic dermatitis, and asthma. Changes attributed to COVID-19 included family economic difficulties, physical activity, breakfast skipping frequency, alcohol consumption, smoking, and depressive moods...
June 8, 2024: Journal of Asthma
Jing Meng, Wei Zhang, Xudong He, Lei Zhang, Xiqian Gu, Yana Xing, Duan Hongmei
OBJECTIVE: This study aimed to develop and validate an instrument to assess the health literacy of parents of children with asthma in a Chinese context. METHODS: The preliminary Parents' Health Literacy Scale for Children with Asthma (PHLSCA) was developed based on a literature review and refined to 45 items through two rounds of expert consultation using the Delphi method. A total of 481 parents of children with asthma were recruited from seven hospitals across four provinces in China between February and April 2019...
June 8, 2024: Journal of Asthma
Shuyu Hu, Liangrong Wang, Miaomiao Zheng, Mengjia Wang, Baihui Chen, Lina Lin
Objective: Protein kinase C (PKC) has been implicated in the increased contraction of human airway smooth muscle cells (HASMCs) in asthma. Using the three-dimensional collagen gel contraction system, the study aimed to determine the effects of LY333531, a specific inhibitor of the PKC-β isoform, on the contraction of tumor necrosis factor (TNF)-α-sensitized HASMCs. Methods: Cultured HASMCs were divided into five groups: the control group received no treatment, and the cells in the TNF-α group were sensitized with 10 ng/mL TNF-α for 48 hours, while TNF-α was administered to sensitize HASMCs in the presence of 0...
June 4, 2024: Journal of Asthma
L S Mahajan, N Granados, A Haines, K Fiori, S P Jariwala
OBJECTIVES: This study assesses the relationship between patient age, gender, race, socioeconomic status, social determinants of health and access to biologics (products isolated from natural sources that target specific molecules, proteins, and cells) in patients with moderate-to-severe asthma in Bronx, NY. METHODS: 289 patients with moderate-to-severe asthma treated at Montefiore Medical Center from 2018 to 2020 was used. Patient demographics, self-reported social needs, and neighborhood socioeconomic characteristics were analyzed...
June 4, 2024: Journal of Asthma
Andrea Yu-Lin Ban, Sri Wahyu Taher, Jaya Muneswarao, Bee Kiau Ho, Rashidi Ahmad, Lalitha Pereirasamy, Li Yin Chong, Shamsuriani Md Jamal, Arvindran Alaga, Helmy Haja Mydin, Li Cheng Chang, Nor Azila Md Isa, Mohd Arif Mohd Zim
OBJECTIVE: Inappropriate use of short-acting beta2-agonists (SABA) in asthma has been associated with undesired outcomes. This national expert consensus was developed to spread awareness of SABA overuse and provide recommendations on the ways to eliminate SABA overprescription and overreliance in asthma care in Malaysia. DATA SOURCES: This expert consensus was developed by searching the PubMed database, using index terms to identify SABA overuse-related burden and recommendations made in asthma guidelines...
June 4, 2024: Journal of Asthma
Carlo Lazzaro
No abstract text is available yet for this article.
May 31, 2024: Journal of Asthma
Amina Alami-Yadri, Imane Ghanname, Abha Cherkani-Hassani, Adil Zagmout, Aida M Benitez-Rexach, Abdellah Bousouf, Khalid Rahhali
This study aimed to analyze the probabilities of transitioning between controlled, uncontrolled, and partially controlled states of asthma patients and investigate the influence of age, smoking, dust allergy, and obesity on these probabilities. Four hundred twenty-four asthma patients from three hospitals in Morocco were included in the study, spanning 42 months.A discrete-time homogeneous Markov model with three states and a single aperiodic recurrent class was used to model the asthma evolution, assuming the regularity of consultations...
May 30, 2024: Journal of Asthma
Aykut Cilli, Fatih Uzer, Gamze Ozbey
BACKGROUND: Clinical remission has recently been proposed as a possible treatment goal even in severe asthma. In this real-world study, we aimed to assess the achievement rate and predictive factors of clinical remission using omalizumab in patients with severe asthma. METHODS: This retrospective observational study included patients with severe asthma initiated with omalizumab therapy and recruited from the asthma clinic of the Akdeniz University Hospital, Turkey...
May 28, 2024: Journal of Asthma
M Asghar Pasha, Russell Hopp, Nazia Habib, Dale Tang
Asthma is a heterogeneous disease with multiple phenotypes that have variable risk factors and therapeutic responses. Airway hyperreactivity, inflammation and airway remodeling are hallmarks of asthma. Asthmatics exhibiting an increase in airway T2 inflammation is now classify as having T2-"high" asthma. Type 2 cytokines, IL-4, IL-5, and IL-13, along with other inflammatory mediators, lead to increased eosinophilic inflammation along with elevated FeNO in this endotype. There is no clear definition for T2-"low" asthma...
May 28, 2024: Journal of Asthma
Nirmin F Juber, Lena M Hofbauer, Francisca S Rodriguez
Previous studies involving asthma and cognitive functioning have produced inconclusive results. In addition, those studies rarely accounted for the age of asthma diagnosis and asthma treatment status. To assess the associations of asthma status or age at asthma diagnosis with cognition using the Telephone Survey of Cognitive Status, we thus analyze data from a large population-based sample. Further, we investigated the possibility that asthma treatment mediates these associations. This is a cross-sectional study from the Indonesian Family Life Survey Fifth Wave (IFLS-5) collected in 2014-2015...
May 28, 2024: Journal of Asthma
Islam Ahmed Abdelmawgood, Ahmed M Sayed, Omnia A Mohamed, Sohaib Ali Ramadan, Jehad Waleed Farg, Wessam Saad, Rahma Sayed Hamdy, Bahaa Sharaf, Hamid Ashry, Mohamed A Kotb
OBJECTIVE: The primary objective of this review is to focus on research findings that aim to determine the immunomodulatory action of ginger's active components and the molecular mechanisms that reduce asthma. The study aims to provide an overview of the scientific literature available on ginger's efficacy in treating allergic asthma.Data Source:The mouse model of asthma has been used to investigate the actions of ginger and its active compounds on allergies and asthma. Various studies and scientific literature on ginger's health-improving qualities and its traditional use have been examined...
May 28, 2024: Journal of Asthma
Shufang Li, Junjun Dong, Aijun Li, Qiuyan Yang, Xiaoman Xiong, Xueli Xie, Yanli Zhang
OBJECTIVE: To investigate the role of 14-3-3β in acute asthma exacerbations in children and analyze the risk factors for asthma exacerbations. METHODS: This study recruited 101 children with acute asthma exacerbations, 101 children with stable asthma, and 65 healthy children. Serum 14-3-3β was compared among the three groups. Factors such as asthma family history, skin prick test, serum-specific IgE test, coinfections, and clinical indicators (FeNO, FEV1, white blood cells, eosinophils, and serum IgE level) were compared between the asthma groups...
May 20, 2024: Journal of Asthma
Raja Dhar, Deepak Talwar, Devasahayam J Christopher, Harjit Dumra, Parvaiz A Koul, Prashant N Chhajed, Sushmita Roychowdhury, Padmanabhan Arjun, Randeep Guleria
Objective In this document, 9 Indian experts have evaluated the factors specific to LMICs when it came to Severe Asthma (SA) diagnosis, evaluation, biologic selection, non-biologic treatment options and follow-up. Data Sources A search was performed using 50 keywords., focusing on the Indian/LMICs perspective, in PubMed, Cochrane Library, and Google Scholar. The key areas of the search were focused on diagnosis, phenoendotyping, non-biological therapies, selecting a biologic, assessment of treatment response and management of exacerbation...
May 20, 2024: Journal of Asthma
Xue Li, Juju Shang, Jian Liu, Yong Zhu
BACKGROUND: This meta-analysis aimed to evaluate the effectiveness and adverse effects of specific immunotherapy (SIT) in the management of respiratory allergens, including allergic asthma, rhinitis, and related disorders, based on a review of current literature up to November 8, 2022. METHODS: We conducted a search of databases, including PubMed, Embase, Cochrane, and Web of Science, to identify relevant randomized controlled trials (RCTs) assessing respiratory allergy-specific immunotherapy...
May 16, 2024: Journal of Asthma
Yu-Cian Lin, Wei-Chun Wang, Hsiang-Lin Lee, Jaw-Ji Tsai, Shao-Hsuan Kao
OBJECTIVE: Der f 2, a major allergen derived from Dermatophagoides farinae , is a leading cause of allergic asthma. IL-6 and GM-CSF play essential roles in the exacerbation of asthma. However, the mechanical act by which Der f 2 mediates the expression of IL-6, IL-8, and GM-CSF in airway epithelial cells remains incompletely elucidated. Herein, we aimed to explore the effect of Der f 2 on IL-6 and GM-CSF expression in the human airway epithelial cell BEAS-2B and A549. METHODS: Recombinant Der f 2 (rDf2) was acquired using Pichia pastoris ...
May 15, 2024: Journal of Asthma
Sanna Kjellberg, Anna-Carin Olin, Linus Schiöler, D Robinson Paul
Small airway dysfunction (SAD) is increasingly recognized as an important feature of pediatric asthma yet typically relies on spirometry-derived FEF25-75 to detect its presence. Multiple breath washout (MBW) and oscillometry potentially offer improved sensitivity for SAD detection, but their utility in comparison to FEF25-75 , and correlations with clinical outcomes remains unclear for school-age asthma.We investigated SAD occurrence using these techniques, between-test correlation and links to clinical outcomes in 57 asthmatic children aged 8-18 years...
May 15, 2024: Journal of Asthma
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