journal
Journals Journal of Antimicrobial Chemo...

Journal of Antimicrobial Chemotherapy

https://read.qxmd.com/read/38758205/tenofovir-emtricitabine-lamivudine-and-dolutegravir-concentrations-in-plasma-and-urine-following-drug-intake-cessation-in-a-randomized-controlled-directly-observed-pharmacokinetic-trial-to-aid-point-of-care-testing
#41
JOURNAL ARTICLE
Laura J Else, Laura Dickinson, Stacey Edick, Ashley Zyhowski, Ken Ho, Leslie Meyn, Sujan Dilly-Penchala, Beth Thompson, Victoria Shaw, Saye Khoo, Rhonda M Brand
BACKGROUND: Poor adherence to ART and pre-exposure prophylaxis (PrEP) can impact patient and public health. Point-of-care testing (POCT) may aid monitoring and adherence interventions. OBJECTIVES: We report the pharmacokinetics of tenofovir [dosed as tenofovir disoproxil (TDF) and tenofovir alafenamide (TAF)], emtricitabine (FTC), lamivudine (3TC) and dolutegravir (DTG) in plasma and urine following drug cessation to evaluate adherence targets in urine for POCT...
May 17, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38758191/effectiveness-safety-and-discontinuation-rates-of-bictegravir-emtricitabine-tenofovir-alafenamide-bic-ftc-taf-in-people-with-hiv-using-real-world-data-a-systematic-review-and-meta-analysis
#42
JOURNAL ARTICLE
Iván Chivite, Leire Berrocal, Elisa de Lazzari, Soodabeh Navadeh, Carla Lluis-Ganella, Alexy Inciarte, Lorena de la Mora, Ana González-Cordón, Maria Martínez-Rebollar, Montserrat Laguno, Berta Torres, José Luis Blanco, Esteban Martínez, Josep Mallolas, Juan Ambrosioni
BACKGROUND: The use of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) is based on the results of robust clinical trials. OBJECTIVES: To assess the effectiveness and safety of BIC/FTC/TAF in treatment-naïve (TN) and treatment-experienced (TE) people with HIV using available real-world cohort studies. METHODS: Systematic review and meta-analysis of publications and communications identified via Boolean search in Medline, PubMed and Embase, and conference abstracts reporting retrospective real-world use of BIC/FTC/TAF, published until 31 January 2024...
May 17, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38758189/global-epidemiology-and-antimicrobial-resistance-of-enterobacterales-harbouring-genes-encoding-oxa-48-like-carbapenemases-insights-from-the-results-of-the-antimicrobial-testing-leadership-and-surveillance-atlas-programme-2018-2021
#43
JOURNAL ARTICLE
Yu-Lin Lee, Wei-Yao Wang, Wen-Chien Ko, Po-Ren Hsueh
OBJECTIVES: The recent emergence of carbapenem-resistant Enterobacterales poses a major and escalating threat to global public health. This study aimed to analyse the global distribution and antimicrobial resistance of Enterobacterales harbouring variant OXA-48-like carbapenemase-related genes. METHODS: Enterobacterales isolates were collected from the Antimicrobial Testing Leadership and Surveillance (ATLAS) programme during 2018-2021. Comprehensive antimicrobial susceptibility testing and β-lactamase gene detection were also conducted, along with statistical analysis of the collected data...
May 17, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38753675/correction-to-oral-antimicrobial-agents-in-patients-with-short-bowel-syndrome-worth-a-try
#44
(no author information available yet)
No abstract text is available yet for this article.
May 16, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38751093/genomic-diversity-and-antimicrobial-resistance-in-clinical-klebsiella-pneumoniae-isolates-from-tertiary-hospitals-in-southern-ghana
#45
JOURNAL ARTICLE
Richael O Mills, Isaac Dadzie, Thanh Le-Viet, David J Baker, Humphrey P K Addy, Samuel A Akwetey, Irene E Donkoh, Elvis Quansah, Prince S Semanshia, Jennifer Morgan, Abraham Mensah, Nana E Adade, Emmanuel O Ampah, Emmanuel Owusu, Philimon Mwintige, Eric O Amoako, Anton Spadar, Kathryn E Holt, Ebenezer Foster-Nyarko
OBJECTIVES: Comprehensive data on the genomic epidemiology of hospital-associated Klebsiella pneumoniae in Ghana are scarce. This study investigated the genomic diversity, antimicrobial resistance patterns, and clonal relationships of 103 clinical K. pneumoniae isolates from five tertiary hospitals in Southern Ghana-predominantly from paediatric patients aged under 5 years (67/103; 65%), with the majority collected from urine (32/103; 31%) and blood (25/103; 24%) cultures. METHODS: We generated hybrid Nanopore-Illumina assemblies and employed Pathogenwatch for genotyping via Kaptive [capsular (K) locus and lipopolysaccharide (O) antigens] and Kleborate (antimicrobial resistance and hypervirulence) and determined clonal relationships using core-genome MLST (cgMLST)...
May 16, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38742712/deciphering-the-accessory-genome-of-a-novel-klebsiella-pneumoniae-lineage-in-the-brazilian-amazon-region-and-its-potential-contribution-to-the-emergence-of-a-high-risk-clone
#46
JOURNAL ARTICLE
Nathália Bighi, Fernanda Freitas, Sérgio Morgado, Rosângela Cipriano, Ana Carolina Vicente, Érica L Fonseca
No abstract text is available yet for this article.
May 14, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38742708/distribution-and-expression-of-the-aac-6-im-aaca16-aminoglycoside-resistance-gene
#47
JOURNAL ARTICLE
Christopher J Harmer, Messiah J Nelson, Francois Lebreton, Paphavee Lertsethtakarn, Patrick T McGann, Ruth M Hall
BACKGROUND: The aac(6')-Im (aacA16) amikacin, netilmicin and tobramycin resistance gene cassette had been circulating globally undetected for many years in a sublineage of Acinetobacter baumannii global clone 2. OBJECTIVES: To identify sources for the aac(6')-Im fragment found in A. baumannii. METHODS: MinION long-read sequencing and Unicycler hybrid assemblies were used to determine the genetic context of the aac(6')-Im gene. Quantitative reverse transcriptase PCR was used to measure expression...
May 14, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38742691/comment-on-in-vitro-activity-of-cefiderocol-against-mbl-producing-gram-negative-bacteria-collected-in-north-america-and-europe-in-five-consecutive-annual-multinational-sidero-wt-surveillance-studies-2014-2019
#48
EDITORIAL
Sathyavani Subbarao, Sara E Boyd, Marina Basarab, Peter Riley
No abstract text is available yet for this article.
May 14, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38742645/metabolic-pathways-and-antimicrobial-peptide-resistance-in-bacteria
#49
JOURNAL ARTICLE
Mohammed Elbediwi, Jens Rolff
Antimicrobial resistance is a pressing concern that poses a significant threat to global public health, necessitating the exploration of alternative strategies to combat drug-resistant microbial infections. Recently, antimicrobial peptides (AMPs) have gained substantial attention as possible replacements for conventional antibiotics. Because of their pharmacodynamics and killing mechanisms, AMPs display a lower risk of bacterial resistance evolution compared with most conventional antibiotics. However, bacteria display different mechanisms to resist AMPs, and the role of metabolic pathways in the resistance mechanism is not fully understood...
May 14, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38742706/the-individual-contributions-of-blab-blagob-and-blacme-on-mics-of-%C3%AE-lactams-in-elizabethkingia-anophelis
#50
JOURNAL ARTICLE
Pei-Jing Chen, Mei-Chen Tan, Wei-Cheng Huang, Shu-Yuan Hsu, Te-Li Chen, Chiou-Ying Yang, Shu-Chen Kuo
BACKGROUND: The blaB, blaGOB and blaCME genes are thought to confer β-lactam resistance to Elizabethkingia anophelis, based on experiments conducted primarily on Escherichia coli. OBJECTIVES: To determine the individual contributions of β-lactamase genes to increased MICs in E. anophelis and to assess their impact on the in vivo efficacy of carbapenem therapy. METHODS: Scarless gene deletion of one or more β-lactamase gene(s) was performed in three clinical E...
May 13, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38727613/skin-pharmacokinetics-of-miltefosine-in-the-treatment-of-post-kala-azar-dermal-leishmaniasis-in-south-asia
#51
JOURNAL ARTICLE
Semra Palić, Wan-Yu Chu, Shyam Sundar, Dinesh Mondal, Pradeep Das, Krishna Pandey, Sheeraz Raja, Suman Rijal, Ignace C Roseboom, Abdullah Hamadeh, Paul R V Malik, Jos H Beijnen, Alwin D R Huitema, Erik Sjögren, Fabiana Alves, Thomas P C Dorlo
INTRODUCTION: Post-kala-azar dermal leishmaniasis (PKDL) arises as a dermal complication following a visceral leishmaniasis (VL) infection. Current treatment options for PKDL are unsatisfactory, and there is a knowledge gap regarding the distribution of antileishmanial compounds within human skin. The present study investigated the skin distribution of miltefosine in PKDL patients, with the aim to improve the understanding of the pharmacokinetics at the skin target site in PKDL. METHODS: Fifty-two PKDL patients underwent treatment with liposomal amphotericin B (20 mg/kg) plus miltefosine (allometric dosing) for 21 days...
May 10, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38725249/implementation-of-the-eucast-rapid-antimicrobial-susceptibility-test-rast-for-carbapenemase-esbl-producing-escherichia-coli-and-klebsiella-pneumoniae-isolates-and-its-effect-on-mortality
#52
JOURNAL ARTICLE
Muhammet Rıdvan Tayşi, Duygu Öcal, Gönül Çiçek Şentürk, Elif Çalişkan, Bahar Çelik, İrfan Şencan
OBJECTIVES: With the rise in antimicrobial resistance, there is a growing demand for rapid antimicrobial susceptibility testing (RAST). In this study, we applied the EUCAST RAST method to ESBL/carbapenemase-producing Escherichia coli and Klebsiella pneumoniae isolates without using advanced identification systems and analysed the effect of this method on mortality rates Also the clinical impact of this method on patients infected with these bacteria and its effect on mortality rates were investigated...
May 10, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38723108/comment-on-molnupiravir-for-the-treatment-of-non-severe-covid-19-a-systematic-review-and-meta-analysis-of-14-randomized-trials-with-34%C3%A2-570-patients
#53
EDITORIAL
I Wen Chen, Li-Chen Chang, Kuo-Chuan Hung
No abstract text is available yet for this article.
May 9, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38722649/correction-to-repurposing-drugs-for-treatment-of-mycobacterium-abscessus-a-view-to-a-kill
#54
(no author information available yet)
No abstract text is available yet for this article.
May 9, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38717472/impact-of-removing-esbl-status-labelling-from-culture-reports-on-the-use-of-carbapenems-for-non-bacteraemic-patients-diagnosed-with-esbl-positive-urinary-tract-infections
#55
JOURNAL ARTICLE
Lourdes R Menendez Alvarado, Alice Margulis Landayan, Kelsey N Williams, Corey M Frederick, Zhenwei Zhang, Timothy P Gauthier
OBJECTIVES: To evaluate carbapenem prescribing rates for initial definitive treatment of urinary tract infections and clinical outcomes before and after removing ESBL status labels on antibiotic susceptibility reports. METHODS: This was a retrospective cohort study of adult patients treated for at least 48 h for an ESBL-producing/ceftriaxone-resistant Enterobacterales urinary tract infection. ESBL status reporting ceased in September 2022 for a network of seven community hospitals within the USA...
May 8, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38717452/prevalence-of-polymyxin-resistant-bacterial-strains-in-india-a-systematic-review-and-meta-analysis
#56
JOURNAL ARTICLE
Sambit K Dwibedy, Indira Padhy, Aditya K Panda, Saswat S Mohapatra
INTRODUCTION: Polymyxins, the cationic lipopeptide antibiotics, are the last line of therapeutics against the MDR Gram-negative bacterial (GNB) pathogens. Unfortunately, the rising cases of polymyxin-resistant strains from across the globe have adversely impacted their utility. While the molecular mechanisms responsible for developing polymyxin resistance (PolR) are largely understood, the prevalence of PolR strains in India has not been investigated systematically. The current study was undertaken to primarily determine the prevalence of PolR strains in India...
May 8, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38714502/temporal-trends-in-antibiotic-prescribing-and-serious-and-nonserious-infections-in-children-presenting-to-general-practice-a-registry-based-longitudinal-cohort-study-of-162%C3%A2-507-individuals
#57
JOURNAL ARTICLE
Ruben Burvenich, Sien De Boodt, Lien Lowie, Arne Janssens, Simon Gabriël Beerten, Bert Vaes, Jaan Toelen, Jan Yvan Verbakel
BACKGROUND: It is crucial to understand the trends in paediatric antibiotic prescribing and serious and nonserious infections to improve antibiotic prescribing practices for children in ambulatory care. OBJECTIVES: Assessing trends in paediatric antibiotic prescribing and infection incidence in general practice from 2002 to 2022. METHODS: In this retrospective cohort study using INTEGO network data from 162 507 patients in Flanders (Belgium), we calculated antibiotic prescribing rates and proportions alongside incidence rates of serious and nonserious infections, stratified by age (0-1, 2-6, 7-12 years) and municipality...
May 8, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38708907/clinical-outcomes-in-patients-with-piperacillin-tazobactam-non-susceptible-but-ceftriaxone-susceptible-e-coli-or-k-pneumoniae-bloodstream-infection
#58
JOURNAL ARTICLE
Ahmad Mourad, Alison G Smith, Jesse D Troy, Thomas L Holland, Rebekah H Wrenn, Nicholas A Turner
BACKGROUND: A small proportion of Escherichia coli and Klebsiella pneumoniae demonstrate in vitro non-susceptibility to piperacillin/tazobactam but retain susceptibility to ceftriaxone. Uncertainty remains regarding how best to treat these isolates. OBJECTIVES: We sought to compare clinical outcomes between patients with piperacillin/tazobactam-non-susceptible but ceftriaxone-susceptible E. coli or K. pneumoniae bloodstream infection receiving definitive therapy with ceftriaxone versus an alternative effective antibiotic...
May 6, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38708644/sedimentation-field-flow-fractionation-for-rapid-phenotypic-antimicrobial-susceptibility-testing-a-pilot-study
#59
JOURNAL ARTICLE
Audrey Gauthier, Linda Tlili, Serge Battu, Coline Le Moan, Marie-Cécile Ploy, Fabrice Lalloue, Gaëlle Bégaud, Olivier Barraud
BACKGROUND: The increase in antibiotic resistance is a major public health issue. The development of rapid antimicrobial susceptibility testing (AST) methods is becoming a priority to ensure early and appropriate antibiotic therapy. OBJECTIVES: To evaluate sedimentation field-flow fractionation (SdFFF) as a method for performing AST in less than 3 h. METHODS: SdFFF is based on the detection of early biophysical changes in bacteria, using a chromatographic-type technology...
May 6, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38708643/use-of-the-febridx%C3%A2-host-response-point-of-care-test-may-reduce-antibiotic-use-for-respiratory-tract-infections-in-primary-care-a-mixed-methods-feasibility-study
#60
JOURNAL ARTICLE
Christopher R Wilcox, Nour Odeh, Tristan W Clark, Ingrid Muller, Taeko Becque, Alexander Todd, Nazrul Islam, Paul Little, Firoza Davies, John McGavin, Nick Francis
INTRODUCTION: FebriDx® is a CE-marked, single-use point-of-care test with markers for bacterial [C-reactive protein (CRP)] and viral [myxovirus resistance protein A (MxA)] infection, using finger-prick blood samples. Results are available after 10-12 min. We explored the usability and potential impact of FebriDx® in reducing antibiotic prescriptions for lower respiratory tract infection (LRTI) in primary care, and the feasibility of conducting a randomized controlled trial (RCT)...
May 6, 2024: Journal of Antimicrobial Chemotherapy
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