journal
Journals Journal of Antimicrobial Chemo...

Journal of Antimicrobial Chemotherapy

https://read.qxmd.com/read/38708643/use-of-the-febridx%C3%A2-host-response-point-of-care-test-may-reduce-antibiotic-use-for-respiratory-tract-infections-in-primary-care-a-mixed-methods-feasibility-study
#21
JOURNAL ARTICLE
Christopher R Wilcox, Nour Odeh, Tristan W Clark, Ingrid Muller, Taeko Becque, Alexander Todd, Nazrul Islam, Paul Little, Firoza Davies, John McGavin, Nick Francis
INTRODUCTION: FebriDx® is a CE-marked, single-use point-of-care test with markers for bacterial [C-reactive protein (CRP)] and viral [myxovirus resistance protein A (MxA)] infection, using finger-prick blood samples. Results are available after 10-12 min. We explored the usability and potential impact of FebriDx® in reducing antibiotic prescriptions for lower respiratory tract infection (LRTI) in primary care, and the feasibility of conducting a randomized controlled trial (RCT)...
May 6, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38708557/human-bronchopulmonary-disposition-and-plasma-pharmacokinetics-of-oral-bemnifosbuvir-at-527-an-experimental-guanosine-nucleotide-prodrug-for-covid-19
#22
JOURNAL ARTICLE
Xiao-Jian Zhou, Arantxa Horga, Adeep Puri, Lee Winchester, Maureen Montrond, Keith Pietropaolo, Bruce Belanger, Courtney V Fletcher, Janet Hammond
BACKGROUND: Bemnifosbuvir (AT-527) is a novel oral guanosine nucleotide antiviral drug for the treatment of persons with COVID-19. Direct assessment of drug disposition in the lungs, via bronchoalveolar lavage, is necessary to ensure antiviral drug levels at the primary site of SARS-CoV-2 infection are achieved. OBJECTIVES: This Phase 1 study in healthy subjects aimed to assess the bronchopulmonary pharmacokinetics, safety and tolerability of repeated doses of bemnifosbuvir...
May 6, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38708553/in-vitro-activity-of-cefiderocol-in-pseudomonas-aeruginosa-isolates-from-people-with-cystic-fibrosis-recovered-during-three-multicentre-studies-in-spain
#23
JOURNAL ARTICLE
Ainhize Maruri-Aransolo, Carla López-Causapé, Marta Hernández-García, María García-Castillo, Juan de Dios Caballero-Pérez, Antonio Oliver, Rafael Cantón
OBJECTIVES: Despite the introduction of cystic fibrosis transmembrane conductance regulator (CFTR) modulators, Pseudomonas aeruginosa is still a major pathogen in people with cystic fibrosis (pwCF). We determine the activity of cefiderocol and comparators in a collection of 154 P. aeruginosa isolates recovered from pwCF during three multicentre studies performed in 17 Spanish hospitals in 2013, 2017 and 2021. METHODS: ISO broth microdilution was performed and MICs were interpreted with CLSI and EUCAST criteria...
May 6, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38661570/correction-to-trends-of-pre-treatment-drug-resistance-in-antiretroviral-na%C3%A3-ve-people-with-hiv-1-in-the-era-of-second-generation-integrase-strand-transfer-inhibitors-in-taiwan
#24
(no author information available yet)
No abstract text is available yet for this article.
April 25, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38661237/fostemsavir-to-overcome-drug-drug-interactions-in-heavily-treatment-experienced-people-with-hiv-and-cancer
#25
JOURNAL ARTICLE
Andrea Giacomelli, Dario Cattaneo, Giacomo Pozza, Davide Moschese, Maria Vittoria Cossu, Davide Dalu, Cristina Gervasoni
No abstract text is available yet for this article.
April 25, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38661223/detection-of-drug-resistant-malaria-in-resource-limited-settings-efficient-and-high-throughput-surveillance-of-artemisinin-and-partner-drug-resistance
#26
JOURNAL ARTICLE
Naoyuki Fukuda, Naoko Yoshida, Betty Balikagala, Ibuki Tsuru, Mie Ikeda, Makoto Hirai, Denis A Anywar, Emannuel I Odongo-Aginya, Toshihiro Mita
OBJECTIVES: Artemisinin-resistant Plasmodium falciparum malaria is currently spreading globally, including in Africa. Artemisinin resistance also leads to resistance to partner drugs used in artemisinin-based combination therapies. Sequencing of kelch13, which is associated with artemisinin resistance, culture-based partner drug susceptibility tests, and ELISA-based growth measurement are conventionally used to monitor resistance; however, their application is challenging in resource-limited settings...
April 25, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38661209/genetic-and-clinical-predictors-of-rifapentine-and-isoniazid-pharmacokinetics-in-paediatrics-with-tuberculosis-infection
#27
JOURNAL ARTICLE
Weeraya Phaisal, Orwa Albitar, Pajaree Chariyavilaskul, Watsamon Jantarabenjakul, Noppadol Wacharachaisurapol, Siti Maisharah Sheikh Ghadzi, Hadzliana Zainal, Sabariah Noor Harun
OBJECTIVES: Twelve weekly doses of rifapentine and isoniazid (3HP regimen) are recommended for TB preventive therapy in children with TB infection. However, they present with variability in the pharmacokinetic profiles. The current study aimed to develop a pharmacokinetic model of rifapentine and isoniazid in 12 children with TB infection using NONMEM. METHODS: Ninety plasma and 41 urine samples were collected at Week 4 of treatment. Drug concentrations were measured using a validated HPLC-UV method...
April 25, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38661207/is-shorter-also-better-in-the-treatment-of-clostridioides-difficile-infection
#28
JOURNAL ARTICLE
M Duricek, K Halmova, M Krutova, B Sykorova, J Benes
OBJECTIVES: To assess the effectiveness of shortened regimens of vancomycin or fidaxomicin in the treatment of Clostridioides difficile infection (CDI). METHODS: Adult patients with CDI hospitalized from January 2022 to May 2023 were included in this observational study. In patients with CDI treated with vancomycin or fidaxomicin, antibiotic treatment was discontinued after either 5 or 7 days of vancomycin or 5 days of fidaxomicin if there was a clinical response and improvement in laboratory parameters...
April 25, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38656584/cardiometabolic-health-in-people-with-hiv-expert-consensus-review
#29
JOURNAL ARTICLE
Rachel L Batterham, Roger J Bedimo, Ricardo S Diaz, Giovanni Guaraldi, Janet Lo, Esteban Martínez, Grace A McComsey, Ana Milinkovic, Toshio Naito, Sebastian Noe, Donal O'Shea, Roger Paredes, Jonathan M Schapiro, Mark S Sulkowski, François Venter, Laura Waters, Ilksen Ungan Yoruk, Benjamin Young
OBJECTIVES: To develop consensus data statements and clinical recommendations to provide guidance for improving cardiometabolic health outcomes in people with HIV based on the knowledge and experience of an international panel of experts. METHODS: A targeted literature review including 281 conference presentations, peer-reviewed articles, and background references on cardiometabolic health in adults with HIV published between January 2016 and April 2022 was conducted and used to develop draft consensus data statements...
April 24, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38656566/correlation-between-antifungal-clinical-practices-and-a-new-clinical-decision-support-system-antifon-clic%C3%A2-for-the-treatment-of-invasive-candidiasis-a-retrospective-multicentre-study
#30
JOURNAL ARTICLE
Anne-Lise Bienvenu, Martin Cour, Patricia Pavese, Céline Guichon, Véronique Leray, Claire Chapuis, Amélie Dureault, Kayvan Mohkam, Salomé Gallet, Stéphanie Bourget, Elham Kahale, Wajih Chaabane, Fabien Subtil, Delphine Maucort-Boulch, François Talbot, Xavier Dode, Jean-Christophe Richard, Gilles Leboucher
BACKGROUND: Invasive candidiasis is still recognized as a major cause of morbidity and mortality. To support clinicians in the optimal use of antifungals for the treatment of invasive candidiasis, a computerized decision support system (CDSS) was developed based on institutional guidelines. OBJECTIVES: To evaluate the correlation of this newly developed CDSS with clinical practices, we set-up a retrospective multicentre cohort study with the aim of providing the concordance rate between the CDSS recommendation and the medical prescription (NCT05656157)...
April 24, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38656557/first-in-human-study-of-alpibectir-bvl-gsk098-a-novel-potent-anti-tb-drug
#31
JOURNAL ARTICLE
Michel Pieren, Ana Abáigar Gutiérrez-Solana, Rosa María Antonijoan Arbós, Gary W Boyle, Myriam Davila, Maria Davy, Marc Gitzinger, Lisa Husband, María S Martínez-Martínez, Dolores Ochoa Mazarro, Eleni Pefani, Sophie L Penman, Modesto J Remuiñán, Georgios Vlasakakis, Markus Zeitlinger, Glenn E Dale
BACKGROUND: The clinical candidate alpibectir augments the activity of, and overcomes resistance to, the anti-TB drug ethionamide in vitro and in vivo. OBJECTIVES: A Phase 1, double-blind, randomized, placebo-controlled study to investigate the safety, tolerability, pharmacokinetics (PK) and food effect of alpibectir administered as single and multiple oral doses in healthy volunteers (NCT04654143). METHODS: Eighty participants were randomized...
April 24, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38656448/plasma-concentrations-of-antiretroviral-drugs-in-a-successful-4-days-a-week-maintenance-treatment-strategy-in-hiv-1-patients-anrs-170-quatuor-trial
#32
JOURNAL ARTICLE
Emuri Abe, Roland Landman, Lambert Assoumou, Karine Amat, Sidonie Lambert-Niclot, Jonathan Bellet, Séverine Gibowski, Pierre-Marie Girard, Laurence Morand-Joubert, Pierre de Truchis, Jean-Claude Alvarez
OBJECTIVES: Charaterization of the plasma concentrations of antiretrovirals in a 4-days-a-week maintenance treatment strategy in the ANRS-170-QUATUOR study. METHODS: Patients were randomized in two groups receiving triple therapy taken 4-days-ON and 3-days-OFF (4/7) or continuous therapy (7/7). Plasma antiretroviral concentrations were monitored during the 'ON-treatment period' (Day 3 or 4 of the 4-day treatment block) and the 'OFF-treatment period' (Day 3 of the 3-day drug cessation) for the 4/7 group, or before the daily drug intake for the 7/7 group, until week-48 (W48)...
April 24, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38637310/posaconazole-in-paediatric-malignancy-and-haematopoietic-stem-cell-transplant-dosing-to-achieve-therapeutic-concentration
#33
JOURNAL ARTICLE
Heather Weerdenburg, Hannah Walker, Nigel Curtis, Stephen Duffull, Gabrielle Haeusler, Theresa Cole, Amanda Gwee
OBJECTIVES: Posaconazole is increasingly used for the treatment and prophylaxis of invasive fungal infections in immunocompromised children. We aimed to review evidence for paediatric posaconazole dosing regimens focusing on attainment of target concentrations and frequency of adverse effects. METHODS: In May 2023, the Cochrane, Embase, MEDLINE and PubMed databases were searched for articles reporting posaconazole dosing in children with malignancy or post-haematopoietic stem cell transplantation...
April 18, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38635670/host-stress-hormone-norepinephrine-reduces-in-vitro-activity-of-aminoglycoside-against-carbapenemase-producing-enterobacterales
#34
JOURNAL ARTICLE
Masato Inaba, Yohei Doi
No abstract text is available yet for this article.
April 18, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38629483/ultra-rapid-selection-of-the-n74d-capsid-inhibitor-resistance-mutation-after-3%C3%A2-weeks-on-lenacapavir
#35
JOURNAL ARTICLE
Marc Wirden, Cecile Pouderoux, Gilles Peytavin, Basma Abdi, Antoine Fayçal, Romain Palich, Marc Antoine Valantin, Sophie Seang, Christine Katlama, Vincent Calvez, Valerie Pourcher, Anne-Geneviève Marcelin
No abstract text is available yet for this article.
April 17, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38629469/iron-efflux-by-ieta-enhances-%C3%AE-lactam-aztreonam-resistance-and-is-linked-to-oxidative-stress-through-cellular-respiration-in-riemerella-anatipestifer
#36
JOURNAL ARTICLE
Mafeng Liu, Mengying Wang, Mi Huang, Qun Gao, Dekang Zhu, Mingshu Wang, Renyong Jia, Shun Chen, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Sai Mao, Bin Tian, Di Sun, Anchun Cheng
BACKGROUND: Riemerella anatipestifer encodes an iron acquisition system, but whether it encodes the iron efflux pump and its role in antibiotic resistance are largely unknown. OBJECTIVES: To screen and identify an iron efflux gene in R. anatipestifer and determine whether and how the iron efflux gene is involved in antibiotic resistance. METHODS: In this study, gene knockout, streptonigrin susceptibility assay and inductively coupled plasma mass spectrometry were used to screen for the iron efflux gene ietA...
April 17, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38629462/pharmacogenetics-of-aminoglycoside-related-ototoxicity-a-systematic-review
#37
JOURNAL ARTICLE
D Gaafar, N Baxter, N Cranswick, J Christodoulou, A Gwee
BACKGROUND: Aminoglycosides (AGs) are important antibiotics in the treatment of Gram-negative sepsis. However, they are associated with the risk of irreversible sensorineural hearing loss (SNHL). Several genetic variants have been implicated in the development of ototoxicity. OBJECTIVES: To evaluate the pharmacogenetic determinants of AG-related ototoxicity. METHODS: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses and was registered on Prospero (CRD42022337769)...
April 17, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38629250/triazole-antifungal-drug-interactions-practical-considerations-for-excellent-prescribing
#38
JOURNAL ARTICLE
Russell Lewis, Saarah Niazi-Ali, Andrew McIvor, Souha S Kanj, Johan Maertens, Matteo Bassetti, Deborah Levine, Andreas H Groll, David W Denning
Systemic antifungal therapy is critical for reducing the mortality from many invasive and chronic fungal infections. Triazole antifungals are the most frequently prescribed antifungals but require attention to dosing and drug interactions. Nearly 600 severe drug-drug interactions and over 1100 moderate interactions requiring dose modifications are described or anticipated with systemic antifungal agents (see https://www.aspergillus.org.uk/antifungal-drug-interactions/). In this article, we address the common and less common, but serious, drug interactions observed in clinical practice with triazole antifungals, including a group of drugs that cannot be prescribed with all or most triazole antifungals (ivabradine, ranolazine, eplerenone, fentanyl, apomorphine, quetiapine, bedaquiline, rifampicin, rifabutin, sirolimus, phenytoin and carbamazepine)...
April 17, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38629145/inappropriate-prescribing-contributes-to-high-antibiotic-exposure-in-young-children-in-australia
#39
JOURNAL ARTICLE
Stejara A Netea, Nicole L Messina, Kaya Gardiner, Laure F Pittet, Nigel Curtis
BACKGROUND: Antibiotic exposure increases antimicrobial resistance and has also been associated with long-term harms, including allergies, inflammatory diseases and weight gain. We assessed antibiotic exposure in the first 2 years of life in Australian children, the factors influencing this and its appropriateness. METHODS: Data from 1201 participants in the MIS BAIR randomized controlled trial were used. Multivariable logistic regression was used to identify factors associated with antibiotic exposure...
April 17, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38629139/occurrence-and-characterization-of-rmtb-harbouring-salmonella-and-escherichia-coli-isolates-from-a-pig-farm-in-the-uk
#40
JOURNAL ARTICLE
Indre Navickaite, Harry Holmes, Letizia Dondi, Luke Randall, Catherine Fearnley, Emma Taylor, Edward Fullick, Robert Horton, Susanna Williamson, Manal AbuOun, Christopher Teale, Muna F Anjum
OBJECTIVES: To characterize and elucidate the spread of amikacin-resistant Enterobacteriaceae isolates from environmental samples on a pig farm in the UK, following the previous identification of index Salmonella isolates harbouring the rmtB gene, a 16S rRNA methylase. METHODS: Environmental samples were collected during two visits to a pig farm in the UK. Isolates were recovered using selective media (amikacin 128 mg/L) followed by real-time PCR and WGS to analyse rmtB-carrying Salmonella and Escherichia coli isolates...
April 17, 2024: Journal of Antimicrobial Chemotherapy
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