journal
Journals Journal of Antimicrobial Chemo...

Journal of Antimicrobial Chemotherapy

https://read.qxmd.com/read/38635670/host-stress-hormone-norepinephrine-reduces-in-vitro-activity-of-aminoglycoside-against-carbapenemase-producing-enterobacterales
#1
JOURNAL ARTICLE
Masato Inaba, Yohei Doi
No abstract text is available yet for this article.
April 18, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38629483/ultra-rapid-selection-of-the-n74d-capsid-inhibitor-resistance-mutation-after-3%C3%A2-weeks-on-lenacapavir
#2
JOURNAL ARTICLE
Marc Wirden, Cecile Pouderoux, Gilles Peytavin, Basma Abdi, Antoine Fayçal, Romain Palich, Marc Antoine Valantin, Sophie Seang, Christine Katlama, Vincent Calvez, Valerie Pourcher, Anne-Geneviève Marcelin
No abstract text is available yet for this article.
April 17, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38629469/iron-efflux-by-ieta-enhances-%C3%AE-lactam-aztreonam-resistance-and-is-linked-to-oxidative-stress-through-cellular-respiration-in-riemerella-anatipestifer
#3
JOURNAL ARTICLE
Mafeng Liu, Mengying Wang, Mi Huang, Qun Gao, Dekang Zhu, Mingshu Wang, Renyong Jia, Shun Chen, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Sai Mao, Bin Tian, Di Sun, Anchun Cheng
BACKGROUND: Riemerella anatipestifer encodes an iron acquisition system, but whether it encodes the iron efflux pump and its role in antibiotic resistance are largely unknown. OBJECTIVES: To screen and identify an iron efflux gene in R. anatipestifer and determine whether and how the iron efflux gene is involved in antibiotic resistance. METHODS: In this study, gene knockout, streptonigrin susceptibility assay and inductively coupled plasma mass spectrometry were used to screen for the iron efflux gene ietA...
April 17, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38629462/pharmacogenetics-of-aminoglycoside-related-ototoxicity-a-systematic-review
#4
JOURNAL ARTICLE
D Gaafar, N Baxter, N Cranswick, J Christodoulou, A Gwee
BACKGROUND: Aminoglycosides (AGs) are important antibiotics in the treatment of Gram-negative sepsis. However, they are associated with the risk of irreversible sensorineural hearing loss (SNHL). Several genetic variants have been implicated in the development of ototoxicity. OBJECTIVES: To evaluate the pharmacogenetic determinants of AG-related ototoxicity. METHODS: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses and was registered on Prospero (CRD42022337769)...
April 17, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38629250/triazole-antifungal-drug-interactions-practical-considerations-for-excellent-prescribing
#5
JOURNAL ARTICLE
Russell Lewis, Saarah Niazi-Ali, Andrew McIvor, Souha S Kanj, Johan Maertens, Matteo Bassetti, Deborah Levine, Andreas H Groll, David W Denning
Systemic antifungal therapy is critical for reducing the mortality from many invasive and chronic fungal infections. Triazole antifungals are the most frequently prescribed antifungals but require attention to dosing and drug interactions. Nearly 600 severe drug-drug interactions and over 1100 moderate interactions requiring dose modifications are described or anticipated with systemic antifungal agents (see https://www.aspergillus.org.uk/antifungal-drug-interactions/). In this article, we address the common and less common, but serious, drug interactions observed in clinical practice with triazole antifungals, including a group of drugs that cannot be prescribed with all or most triazole antifungals (ivabradine, ranolazine, eplerenone, fentanyl, apomorphine, quetiapine, bedaquiline, rifampicin, rifabutin, sirolimus, phenytoin and carbamazepine)...
April 17, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38629145/inappropriate-prescribing-contributes-to-high-antibiotic-exposure-in-young-children-in-australia
#6
JOURNAL ARTICLE
Stejara A Netea, Nicole L Messina, Kaya Gardiner, Laure F Pittet, Nigel Curtis
BACKGROUND: Antibiotic exposure increases antimicrobial resistance and has also been associated with long-term harms, including allergies, inflammatory diseases and weight gain. We assessed antibiotic exposure in the first 2 years of life in Australian children, the factors influencing this and its appropriateness. METHODS: Data from 1201 participants in the MIS BAIR randomized controlled trial were used. Multivariable logistic regression was used to identify factors associated with antibiotic exposure...
April 17, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38629139/occurrence-and-characterization-of-rmtb-harbouring-salmonella-and-escherichia-coli-isolates-from-a-pig-farm-in-the-uk
#7
JOURNAL ARTICLE
Indre Navickaite, Harry Holmes, Letizia Dondi, Luke Randall, Catherine Fearnley, Emma Taylor, Edward Fullick, Robert Horton, Susanna Williamson, Manal AbuOun, Christopher Teale, Muna F Anjum
OBJECTIVES: To characterize and elucidate the spread of amikacin-resistant Enterobacteriaceae isolates from environmental samples on a pig farm in the UK, following the previous identification of index Salmonella isolates harbouring the rmtB gene, a 16S rRNA methylase. METHODS: Environmental samples were collected during two visits to a pig farm in the UK. Isolates were recovered using selective media (amikacin 128 mg/L) followed by real-time PCR and WGS to analyse rmtB-carrying Salmonella and Escherichia coli isolates...
April 17, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38619055/accumulibacter-spp-as-the-origin-of-the-oxa-198-carbapenemase-gene-cassette
#8
JOURNAL ARTICLE
Aymeric Jacquemin, Thierry Naas, Laurent Dortet, Rémy A Bonnin
No abstract text is available yet for this article.
April 15, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38598696/genetic-determinants-of-resistance-to-antimicrobial-therapeutics-are-rare-in-publicly-available-clostridioides-difficile-genome-sequences
#9
JOURNAL ARTICLE
Baban Kolte, Ulrich Nübel
OBJECTIVES: To determine the frequencies and clonal distributions of putative genetic determinants of resistance to antimicrobials applied for treatment of Clostridioides difficile infection (CDI), as documented in the genomic record. METHODS: We scanned 26 557 C. difficile genome sequences publicly available from the EnteroBase platform for plasmids, point mutations and gene truncations previously reported to reduce susceptibility to vancomycin, fidaxomicin or metronidazole, respectively...
April 10, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38598449/extrapolation-of-lung-pharmacokinetics-of-antitubercular-drugs-from-preclinical-species-to-humans-using-pbpk-modelling
#10
JOURNAL ARTICLE
Evangelos Karakitsios, Aristides Dokoumetzidis
OBJECTIVES: To develop physiologically based pharmacokinetic (PBPK) models for widely used anti-TB drugs, namely rifampicin, pyrazinamide, isoniazid, ethambutol and moxifloxacin lung pharmacokinetics (PK)-regarding both healthy and TB-infected tissue (cellular lesion and caseum)-in preclinical species and to extrapolate to humans. METHODS: Empirical models were used for the plasma PK of each species, which were connected to multicompartment permeability-limited lung models within a middle-out PBPK approach with an appropriate physiological parameterization that was scalable across species...
April 10, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38597137/population-pharmacokinetic-pharmacodynamic-target-attainment-analysis-of-iv-fosfomycin-for-the-treatment-of-mdr-gram-negative-bacterial-infections
#11
JOURNAL ARTICLE
Walaiporn Wangchinda, Jason M Pogue, Visanu Thamlikitkul, Pannee Leelawattanachai, Pornpan Koomanachai, Manjunath P Pai
BACKGROUND: IV fosfomycin is used against MDR Gram-negative bacilli (GNB) but has dose-limiting side effects, especially in patients with impaired kidney function. OBJECTIVES: To determine the optimal dosage of IV fosfomycin for patients with varying degrees of kidney function. METHODS: Adult patients receiving IV fosfomycin for treatment of GNB were eligible. Five serial blood samples were collected after at least three doses of fosfomycin; plasma was assayed by LC-MS/MS and modelled by population pharmacokinetic analysis...
April 10, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38581349/long-term-outcomes-of-bictegravir-emtricitabine-tenofovir-alafenamide-as-first-line-therapy-and-as-switch-strategy-in-virologically-suppressed-persons-with-hiv-data-from-the-icona-cohort
#12
JOURNAL ARTICLE
Antonella d'Arminio Monforte, Alessandro Tavelli, Antonio Di Biagio, Loredana Sarmati, Giulia C Marchetti, Francesca Bai, Antonella Cingolani, Eugenio Quiros Roldan, Cristina Mussini, Miriam Lichtner, Alessandra Vergori, Stefania Piconi, Giancarlo Orofino, Francesco Maria Fusco, Alessandra Bandera, Silvia Nozza, Antonella Castagna, Andrea Antinori
OBJECTIVES: To assess the effectiveness of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) among people poorly represented in clinical trials and potentially at higher risk of suboptimal response to ART. METHODS: Observational cohort study on persons with HIV (PWH) enrolled in ICONA who started BIC/FTC/TAF as initial therapy or as switching regimen while virologically suppressed. Primary endpoint was time to treatment failure (TF): new AIDS/death or virological failure (VF) or discontinuation for toxicity/failure...
April 6, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38581308/a-comparison-of-strategies-for-identifying-patients-at-risk-for-carbapenem-resistant-or-extended-%C3%AE-lactam-resistant-pseudomonas-aeruginosa
#13
JOURNAL ARTICLE
Walaiporn Wangchinda, Keith S Kaye, Twisha S Patel, Owen R Albin, Louis Saravolatz, Joshua G Petrie, Jason M Pogue
OBJECTIVES: To assess risk factors for carbapenem-resistant Pseudomonas aeruginosa (CR) and extended-β-lactam-resistant P. aeruginosa (EBR) infection/colonization, and to develop and compare tools for predicting isolation of CR and EBR from clinical cultures. METHODS: This retrospective study analysed hospitalized patients with positive P. aeruginosa cultures between 2015 and 2021. Two case-control analyses were performed to identify risk factors and develop scoring tools for distinguishing patients with CR versus carbapenem-susceptible (CS) P...
April 6, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38581098/ten-year-results-of-an-international-external-quality-control-programme-for-measurement-of-anti-tuberculosis-drug-concentrations
#14
JOURNAL ARTICLE
Ralf Stemkens, Chaima Mouhdad, Eric J F Franssen, Daniel Touw, Jan-Willem Alffenaar, Lindsey H M Te Brake, Marieke G G Sturkenboom, Rob E Aarnoutse
OBJECTIVES: Participation in an external (interlaboratory) quality control (QC) programme is an essential part of quality assurance as it provides laboratories with valuable insights into their analytical performance. We describe the 10 year results of an international QC programme for the measurement of anti-tuberculosis (TB) drugs. METHODS: Each year, two rounds were organized in which serum (or plasma) samples, spiked with known concentrations of anti-TB drugs, were provided to participating laboratories for analysis...
April 6, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38574003/tandem-amplification-of-a-plasmid-borne-tet-a-variant-gene-confers-tigecycline-resistance-in-escherichia-coli
#15
JOURNAL ARTICLE
Chenhui Zou, Chunyan Xu, Runhao Yu, Xinxin Shan, Stefan Schwarz, Dexi Li, Xiang-Dang Du
OBJECTIVES: To elucidate the mechanism of tigecycline resistance in Escherichia coli that is mediated by the tet(A) variant gene. METHODS: E. coli strain 573 carried a plasmid-borne tet(A) variant gene, tentatively designated tet(A)TIG, that conferred decreased tigecycline susceptibility (MIC 0.5 mg/L). When exposed to increasing concentrations of tigecycline (0.25-8 mg/L), mutants growing at 2, 4 and 8 mg/L were obtained and sequenced. Copies of plasmid and tet(A)TIG relative to the chromosomal DNA in the mutants were determined by WGS and quantitative PCR (qPCR)...
April 4, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38573940/continuous-evaluation-of-single-dose-moxifloxacin-concentrations-in-brain-extracellular-fluid-cerebrospinal-fluid-and-plasma-a-novel-porcine-model
#16
JOURNAL ARTICLE
T Mariager, J H Terkelsen, M Bue, K Öbrink-Hansen, R Nau, C R Bjarkam, H Nielsen, J Bodilsen
BACKGROUND: Knowledge regarding CNS pharmacokinetics of moxifloxacin is limited, with unknown consequences for patients with meningitis caused by bacteria resistant to beta-lactams or caused by TB. OBJECTIVE: (i) To develop a novel porcine model for continuous investigation of moxifloxacin concentrations within brain extracellular fluid (ECF), CSF and plasma using microdialysis, and (ii) to compare these findings to the pharmacokinetic/pharmacodynamic (PK/PD) target against TB...
April 4, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38569058/influence-of-ultrafiltration-conditions-on-the-measurement-of-unbound-drug-concentrations-flucloxacillin-as-an-example
#17
JOURNAL ARTICLE
Nynke G L Jager, Eleonora Van Ewijk-Beneken Kolmer, Rob Aarnoutse, Lindsey H M Te Brake
BACKGROUND: When performing therapeutic drug monitoring (TDM) for flucloxacillin, it is advised to measure the unbound, not the total, flucloxacillin concentration. To be able to accurately quantify unbound flucloxacillin concentrations, a reliable analytical method is indispensable. OBJECTIVE: To determine the influence of temperature and pH of the sample during ultrafiltration on the measured unbound fraction of flucloxacillin. MATERIALS AND METHODS: We performed three different experiments...
April 3, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38564262/performance-of-disk-diffusion-method-for-aztreonam-in-combination-with-avibactam-against-enterobacteriales
#18
JOURNAL ARTICLE
Dandan Yin, Peipei Song, Lan Jiang, Jian Xu, Fupin Hu
OBJECTIVES: To evaluate the performance of an in-house developed disk diffusion method for aztreonam in combination with avibactam against Enterobacteriales. METHODS: The in vitro antibacterial activity of aztreonam with avibactam against 204 carbapenemase-producing Enterobacteriales was determined by a disk diffusion method, with a broth microdilution method as a reference. RESULTS: The optimal S/R breakpoints for disk diffusion tests of 30/20 and 10/4 µg disks, calculated by the dBETs software using the model-based approaches, were ≥22/≤21 and ≥12/≤11 mm, respectively...
April 2, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38564257/a-serial-passage-experiment-to-assess-the-development-of-resistance-to-ertapenem-and-meropenem-among-enterobacterales
#19
JOURNAL ARTICLE
Yosef Nissim, P Rocco LaSala, Douglas Slain
No abstract text is available yet for this article.
April 2, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38564255/methicillin-resistance-in-staphylococcus-pseudintermedius-encoded-within-novel-staphylococcal-cassette-chromosome-mec-sccmec-variants
#20
JOURNAL ARTICLE
A C MacFadyen, G K Paterson
BACKGROUND: Staphylococcus pseudintermedius is a common opportunistic pathogen of companion dogs and an occasional human pathogen. Treatment is hampered by antimicrobial resistance including methicillin resistance encoded by mecA within the mobile genetic element SCCmec. OBJECTIVES: SCCmec elements are diverse, especially in non-Staphyloccocus aureus staphylococci, and novel variants are likely to be present in S. pseudintermedius. The aim was to characterize the SCCmec elements found in four canine clinical isolates of S...
April 2, 2024: Journal of Antimicrobial Chemotherapy
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