Isaac Alonso-García, Juan Carlos Vázquez-Ucha, Cristina Lasarte-Monterrubio, Elena González-Mayo, Paula Lada-Salvador, Ramón Vela-Fernández, Pablo Aja-Macaya, Paula Guijarro-Sánchez, Soraya Rumbo-Feal, María Muíño-Andrade, Ana Fernández-González, Marta Martínez-Guitián, Alejandro Beceiro, Manuel Rodríguez-Iglesias, Antonio Oliver, Jorge Arca-Suárez, Fátima Galán-Sánchez, Germán Bou
OBJECTIVES: To describe and characterize the emergence of resistance to ceftolozane/tazobactam, ceftazidime/avibactam and imipenem/relebactam in a patient receiving ceftazidime/avibactam treatment for an MDR Pseudomonas aeruginosa CNS infection. METHODS: One baseline (PA1) and two post-exposure (PA2 and PA3) isolates obtained before and during treatment of a nosocomial P. aeruginosa meningoventriculitis were evaluated. MICs were determined by broth microdilution...
March 15, 2023: Journal of Antimicrobial Chemotherapy