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Journal of the American Society of Nephrology : JASN

https://read.qxmd.com/read/33239394/missing-self-induced-activation-of-nk-cells-combines-with-non-complement-fixing-donor-specific-antibodies-to-accelerate-kidney-transplant-loss-in-chronic-antibody-mediated-rejection
#21
Alice Koenig, Sarah Mezaache, Jasper Callemeyn, Thomas Barba, Virginie Mathias, Antoine Sicard, Béatrice Charreau, Maud Rabeyrin, Frédérique Dijoud, Cécile Picard, Vannary Meas-Yedid, Jean-Christophe Olivo-Marin, Emmanuel Morelon, Maarten Naesens, Valérie Dubois, Olivier Thaunat
BACKGROUND: Binding of donor-specific antibodies (DSAs) to kidney allograft endothelial cells that does not activate the classic complement cascade can trigger the recruitment of innate immune effectors, including NK cells. Activated NK cells contribute to microvascular inflammation leading to chronic antibody-mediated rejection (AMR). Recipient NK cells can also trigger antibody-independent microvascular inflammation by sensing the absence of self HLA class I molecules ("missing self") on allograft endothelial cells...
November 25, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33239393/kidney-single-cell-transcriptomes-predict-spatial-corticomedullary-gene-expression-and-tissue-osmolality-gradients
#22
Christian Hinze, Nikos Karaiskos, Anastasiya Boltengagen, Katharina Walentin, Klea Redo, Nina Himmerkus, Markus Bleich, S Steven Potter, Andrew S Potter, Kai-Uwe Eckardt, Christine Kocks, Nikolaus Rajewsky, Kai M Schmidt-Ott
BACKGROUND: Single-cell transcriptomes from dissociated tissues provide insights into cell types and their gene expression and may harbor additional information on spatial position and the local microenvironment. The kidney's cells are embedded into a gradient of increasing tissue osmolality from the cortex to the medulla, which may alter their transcriptomes and provide cues for spatial reconstruction. METHODS: Single-cell or single-nuclei mRNA sequencing of dissociated mouse kidneys and of dissected cortex, outer, and inner medulla, to represent the corticomedullary axis, was performed...
November 25, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33239392/prediction-of-kidney-drug-clearance-a-comparison-of-tubular-secretory-clearance-and-glomerular-filtration-rate
#23
Yan Chen, Leila R Zelnick, Andrew N Hoofnagle, Catherine K Yeung, Laura M Shireman, Brian Phillips, Calder C Brauchla, Ian de Boer, Linda Manahan, Susan R Heckbert, Jonathan Himmelfarb, Bryan R Kestenbaum
BACKGROUND: Although proximal tubular secretion is the primary mechanism of kidney drug elimination, current kidney drug dosing strategies are on the basis of eGFR. METHODS: In a dedicated pharmacokinetic study to compare GFR with tubular secretory clearance for predicting kidney drug elimination, we evaluated stable outpatients with eGFRs ranging from 21 to 140 ml/min per 1.73 m2 . After administering single doses of furosemide and famciclovir (metabolized to penciclovir), we calculated their kidney clearances on the basis of sequential plasma and timed urine measurements...
November 25, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33214201/covid-19-associated-glomerular-disease
#24
Aneesha A Shetty, Ibrahim Tawhari, Luisa Safar-Boueri, Nay Seif, Ameen Alahmadi, Richard Gargiulo, Vikram Aggarwal, Irtaza Usman, Sergey Kisselev, Ali G Gharavi, Yahspal Kanwar, Susan E Quaggin
BACKGROUND: Studies have documented AKI with high-grade proteinuria in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In some patients, biopsies have revealed collapsing glomerulopathy, a distinct form of glomerular injury that has been associated with other viruses, including HIV. Previous patient reports have described patients of African ancestry who developed nephrotic-range proteinuria and AKI early in the course of disease. METHODS: In this patient series, we identified six patients with coronavirus disease 2019 (COVID-19), AKI, and nephrotic-range proteinuria...
November 19, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33184124/childhood-cancer-and-the-risk-of-eskd
#25
Ronit Calderon-Margalit, Oren Pleniceanu, Dorit Tzur, Michal Stern-Zimmer, Arnon Afek, Tomer Erlich, Guy Verhovsky, Lital Keinan-Boker, Karl Skorecki, Gilad Twig, Asaf Vivante
BACKGROUND: Increasing cancer incidence among children alongside improved treatments has resulted in a growing number of pediatric cancer survivors. Despite childhood cancer survivors' exposure to various factors that compromise kidney function, few studies have investigated the association between childhood cancer and future kidney disease. METHODS: To assess the risk of ESKD among childhood cancer survivors, we conducted a nationwide, population-based, retrospective cohort study that encompassed all Israeli adolescents evaluated for mandatory military service from 1967 to 1997...
November 12, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33177116/inflammatory-bowel-disease-is-more-common-in-patients-with-iga-nephropathy-and-predicts-progression-of-eskd-a-swedish-population-based-cohort-study
#26
Johanna Rehnberg, Adina Symreng, Jonas F Ludvigsson, Louise Emilsson
BACKGROUND: Case reports suggest an association between inflammatory bowel disease, a chronic autoimmune condition linked to increased circulating IgA levels, and IgA nephropathy, the most common form of primary GN and a leading cause of ESKD. METHODS: In a Swedish population-based cohort study, we compared 3963 biopsy-verified IgA nephropathy patients with 19,978 matched controls between 1974 and 2011, following up participants until 2015. Inflammatory bowel disease data and ESKD status were obtained through national medical registers...
November 11, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33174862/complexities-of-egfrs-in-a-study-of-glomerular-physiology
#27
LETTER
Robert W Steiner
No abstract text is available yet for this article.
November 9, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33170135/authors-reply
#28
LETTER
Didier Collard, Lennart van de Velde, Liffert Vogt, Bert-Jan H van den Born
No abstract text is available yet for this article.
November 9, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33170136/post-mortem-diagnostics-in-covid-19-aki-more-often-but-timely
#29
LETTER
Jan G Zijlstra, Matijs van Meurs, Jill Moser
No abstract text is available yet for this article.
November 5, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33155987/authors-reply
#30
LETTER
Jordan L Rosenstock, Vanesa Bijol
No abstract text is available yet for this article.
November 5, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33154175/deep-learning-based-segmentation-and-quantification-in-experimental-kidney-histopathology
#31
Nassim Bouteldja, Barbara M Klinkhammer, Roman D Bülow, Patrick Droste, Simon W Otten, Saskia Freifrau von Stillfried, Julia Moellmann, Susan M Sheehan, Ron Korstanje, Sylvia Menzel, Peter Bankhead, Matthias Mietsch, Charis Drummer, Michael Lehrke, Rafael Kramann, Jürgen Floege, Peter Boor, Dorit Merhof
BACKGROUND: Nephropathologic analyses provide important outcomes-related data in experiments with the animal models that are essential for understanding kidney disease pathophysiology. Precision medicine increases the demand for quantitative, unbiased, reproducible, and efficient histopathologic analyses, which will require novel high-throughput tools. A deep learning technique, the convolutional neural network, is increasingly applied in pathology because of its high performance in tasks like histology segmentation...
November 5, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33154174/incidence-characteristics-and-outcome-of-covid-19-in-adults-on-kidney-replacement-therapy-a-regionwide-registry-study
#32
Johan De Meester, Dirk De Bacquer, Maarten Naesens, Bjorn Meijers, Marie M Couttenye, An S De Vriese
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection disproportionally affects frail, elderly patients and those with multiple chronic comorbidities. Whether patients on RRT have an additional risk because of their specific exposure and complex immune dysregulation is controversial. METHODS: To describe the incidence, characteristics, and outcomes of SARS-CoV-2 infection, we conducted a prospective, multicenter, region-wide registry study in adult patients on RRT versus the general population from March 2 to May 25, 2020...
November 5, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33148615/neutrophil-macrophage-imbalance-drives-the-development-of-renal-scarring-during-experimental-pyelonephritis
#33
Juan de Dios Ruiz-Rosado, Frank Robledo-Avila, Hanna Cortado, Javier Rangel-Moreno, Sheryl S Justice, Ching Yang, John David Spencer, Brian Becknell, Santiago Partida-Sanchez
BACKGROUND: In children, the acute pyelonephritis that can result from urinary tract infections (UTIs), which commonly ascend from the bladder to the kidney, is a growing concern because it poses a risk of renal scarring and irreversible loss of kidney function. To date, the cellular mechanisms underlying acute pyelonephritis-driven renal scarring remain unknown. METHODS: We used a preclinical model of uropathogenic Escherichia coli -induced acute pyelonephritis to determine the contribution of neutrophils and monocytes to resolution of the condition and the subsequent development of kidney fibrosis...
November 4, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33122288/association-of-multiple-plasma-biomarker-concentrations-with-progression-of-prevalent-diabetic-kidney-disease-findings-from-the-chronic-renal-insufficiency-cohort-cric-study
#34
Sarah J Schrauben, Haochang Shou, Xiaoming Zhang, Amanda Hyre Anderson, Joseph V Bonventre, Jing Chen, Steven Coca, Susan L Furth, Jason H Greenberg, Orlando M Gutierrez, Joachim H Ix, James P Lash, Chirag R Parikh, Casey M Rebholz, Venkata Sabbisetti, Mark J Sarnak, Michael G Shlipak, Sushrut S Waikar, Paul L Kimmel, Ramachandran S Vasan, Harold I Feldman, Jeffrey R Schelling
BACKGROUND: Although diabetic kidney disease is the leading cause of ESKD in the United States, identifying those patients who progress to ESKD is difficult. Efforts are under way to determine if plasma biomarkers can help identify these high-risk individuals. METHODS: In our case-cohort study of 894 Chronic Renal Insufficiency Cohort Study participants with diabetes and an eGFR of <60 ml/min per 1.73 m2 at baseline, participants were randomly selected for the subcohort; cases were those patients who developed progressive diabetic kidney disease (ESKD or 40% eGFR decline)...
October 29, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33122286/transcriptomes-of-major-proximal-tubule-cell-culture-models
#35
Syed J Khundmiri, Lihe Chen, Eleanor D Lederer, Chin-Rang Yang, Mark A Knepper
BACKGROUND: Cultured cell lines are widely used for research in the physiology, pathophysiology, toxicology, and pharmacology of the renal proximal tubule. The lines that are most appropriate for a given use depend upon the genes expressed. New tools for transcriptomic profiling using RNA sequencing (RNA-Seq) make it possible to catalog expressed genes in each cell line. METHODS: Fourteen different proximal tubule cell lines, representing six species, were grown on permeable supports under conditions specific for the respective lines...
October 29, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33115918/covid-19-associated-acute-kidney-injury-learning-from-the-first-wave
#36
EDITORIAL
Ron Wald, Sean M Bagshaw
No abstract text is available yet for this article.
October 28, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33115916/differences-in-25-hydroxyvitamin-d-clearance-by-egfr-and-race-a-pharmacokinetic-study
#37
Simon Hsu, Leila R Zelnick, Yvonne S Lin, Cora M Best, Bryan Kestenbaum, Kenneth E Thummel, Lynn M Rose, Andrew N Hoofnagle, Ian H de Boer
BACKGROUND: Conversion of 25-hydroxyvitamin D (25[OH]D) to the active form of vitamin D occurs primarily in the kidney. Observational studies suggest 25(OH)D clearance from the circulation differs by kidney function and race. However, these potential variations have not been tested using gold-standard methods. METHODS: We administered intravenous, deuterated 25(OH)D3 (d-25[OH]D3 ) in a pharmacokinetic study of 87 adults, including 43 with normal eGFR (≥60 ml/min per 1...
October 28, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33376112/sphingosine-1-phosphate-metabolism-and-signaling-in-kidney-diseases
#38
Yelena Drexler, Judith Molina, Alla Mitrofanova, Alessia Fornoni, Sandra Merscher
In the past few decades, sphingolipids and sphingolipid metabolites have gained attention because of their essential role in the pathogenesis and progression of kidney diseases. Studies in models of experimental and clinical nephropathies have described accumulation of sphingolipids and sphingolipid metabolites, and it has become clear that the intracellular sphingolipid composition of renal cells is an important determinant of renal function. Proper function of the glomerular filtration barrier depends heavily on the integrity of lipid rafts, which include sphingolipids as key components...
January 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33288631/covid-19-and-apol1-understanding-disease-mechanisms-through-clinical-observation
#39
EDITORIAL
David J Friedman
No abstract text is available yet for this article.
January 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33168602/comparison-of-the-efficacy-and-safety-of-tacrolimus-and-low-dose-corticosteroid-with-high-dose-corticosteroid-for-minimal-change-nephrotic-syndrome-in-adults
#40
Ho Jun Chin, Dong-Wan Chae, Yong Chul Kim, Won Suk An, ChunGyoo Ihm, Dong-Chan Jin, Sung Gyun Kim, Yong-Lim Kim, Yong-Soo Kim, Yoon-Goo Kim, Ho Seok Koo, Jung Eun Lee, Kang Wook Lee, Jieun Oh, Jung Hwan Park, Hongsi Jiang, Hyuncheol Lee, Sang Koo Lee
BACKGROUND: Tacrolimus is used as a steroid-sparing immunosuppressant in adults with minimal change nephrotic syndrome. However, combined treatment with tacrolimus and low-dose steroid has not been compared with high-dose steroid for induction of clinical remission in a large-scale randomized study. METHODS: In this 24-week open-label noninferiority study, we randomized 144 adults with minimal change nephrotic syndrome to receive 0.05 mg/kg twice-daily tacrolimus plus once-daily 0...
January 2021: Journal of the American Society of Nephrology: JASN
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