Journal of the American Society of Nephrology : JASN

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No abstract text is available yet for this article.

BACKGROUND: Individuals receiving hemodialysis have high incidence of sudden cardiac death and are susceptible to QT interval prolonging medication-related cardiac complications. Ondansetron, an antiemetic with known QT prolonging potential, is associated with fatal arrythmias in the general population when administered intravenously. The cardiac safety of ondansetron in the hemodialysis population is unknown. METHODS: We conducted a new-user, active-comparator, cohort study using US Renal Data System data (2012-2019) to examine the association between the initiation of oral ondansetron vs...

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No abstract text is available yet for this article.

No abstract text is available yet for this article.

Kidney Injury Molecule-1 (KIM-1), also known as T cell immunoglobulin and mucin domain-1 (TIM-1), is a widely recognized biomarker for acute kidney injury, but its biological function is less appreciated. KIM-1/TIM-1 belongs to the TIM family of conserved transmembrane proteins which bear the characteristic six-cysteine immunoglobulin-like (IgV) domain. The latter enables binding of KIM-1/TIM-1 to its natural ligand, phosphatidylserine, expressed on the surface of apoptotic cells and necrotic cells. KIM-1/TIM-1 is expressed in a variety of tissues and plays fundamental roles in regulating sterile inflammation and adaptive immune responses...

BACKGROUND: Kidney endothelial cells are exposed to different microenvironmental conditions that support specific physiological processes. However, the heterogeneity of human kidney endothelial cells has not yet been systematically described. METHODS: We reprocessed and integrated 7 datasets of human kidney control single cell/single nucleus RNA sequencing (sc/snRNAseq) datasets of >200,000 kidney cells in the same process. RESULTS: We identified five major cell types, 29,992 of which were endothelial cells...

BACKGROUND: Despite known benefits of kidney transplantation, including transplantation from donors with increased risk factors, many waitlisted candidates die prior to transplantation. Consent to receive donor kidneys with lower expected survival (e.g. kidney donor profile index [KDPI]>85%) is typically obtained at waitlist placement. The presumed benefit of consent to receive high-KDPI donor kidneys is increased likelihood and timeliness of donor offers for transplantation. However, the specific impact of consent on access to transplantation is unclear...

BACKGROUND: Kidney collecting ducts are comprised of principal cells and intercalated cells, with intercalated cells playing a crucial role in kidney acid-base regulation through H+ and HCO3- secretion. Despite its significance, the molecular mechanisms controlling intercalated cell development remain incompletely understood. METHODS: To investigate the specific role of Foxp1 in kidney tubular system, we specifically deleted Foxp1 expression in kidney distal nephrons and collecting ducts...

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SIGNIFICANCE STATEMENT: The renal lymphatic vasculature and the lymphatic endothelial cells that make up this network play important immunomodulatory roles during inflammation. How lymphatics respond to AKI may affect AKI outcomes. The authors used single-cell RNA sequencing to characterize mouse renal lymphatic endothelial cells in quiescent and cisplatin-injured kidneys. lymphatic endothelial cell gene expression changes were confirmed in ischemia-reperfusion injury and in cultured lymphatic endothelial cells, validating renal lymphatic endothelial cells single-cell RNA sequencing data...

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BACKGROUND: Inorganic phosphate (Pi) is an essential mineral, and its plasma levels are tightly regulated. In mammals, kidneys are critical for maintaining Pi-homeostasis through mechanisms that ultimately regulate the expression of the Na+/Pi cotransporters NaPi-IIa and NaPi-IIc in proximal tubules. Inositol pyrophosphate 5-IP7, generated by inositol hexakisphosphate kinases (IP6Ks), is a main regulator of Pi-metabolism in yeast and plants. IP6Ks are conserved in mammals but their role in Pi-metabolism in vivo remains unexplored...

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INTRODUCTION: Substantial changes in End Stage Kidney Disease (ESKD) incidence over four decades among Black and White Americans of different ages have been incompletely explored. METHODS: We analyzed United States Renal Data System data from 1980-2019 to determine ESKD incidence trends among Black and White adolescent (13-17 years), adult (18-64 years), and older adult (≥65) populations. We used the National Cancer Institute Joinpoint Regression Program to estimate Annual Percent Change in ESKD incidence and to define points in time where a statistically significant change in Annual Percent Change slope occurred for each group...

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Hemodialysis (HD) is a life-saving treatment for patients with kidney failure. However, patients requiring HD have a 10-20 times higher risk of cardiovascular (CV) morbidity and mortality than that of the general population. Patients encounter complications such as episodic intradialytic hypotension (IDH), abnormal perfusion to critical organs (heart, brain, liver, and kidney) and damage to vulnerable vascular beds. Recurrent conventional HD exposes patients to multiple episodes of circulatory stress, exacerbating and being aggravated by microvascular endothelial dysfunction...