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Journal of the American Society of Nephrology : JASN

https://read.qxmd.com/read/33462082/the-road-ahead-for-research-on-air-pollution-and-kidney-disease
#1
EDITORIAL
Ziyad Al-Aly, Benjamin Bowe
No abstract text is available yet for this article.
January 18, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33462081/subtyping-ckd-patients-by-consensus-clustering-the-chronic-renal-insufficiency-cohort-cric-study
#2
Zihe Zheng, Sushrut S Waikar, Insa M Schmidt, J Richard Landis, Chi-Yuan Hsu, Tariq Shafi, Harold I Feldman, Amanda H Anderson, Francis P Wilson, Jing Chen, Hernan Rincon-Choles, Ana C Ricardo, Georges Saab, Tamara Isakova, Radhakrishna Kallem, Jeffrey C Fink, Panduranga S Rao, Dawei Xie, Wei Yang
BACKGROUND: CKD is a heterogeneous condition with multiple underlying causes, risk factors, and outcomes. Subtyping CKD with multidimensional patient data holds the key to precision medicine. Consensus clustering may reveal CKD subgroups with different risk profiles of adverse outcomes. METHODS: We used unsupervised consensus clustering on 72 baseline characteristics among 2696 participants in the prospective Chronic Renal Insufficiency Cohort (CRIC) study to identify novel CKD subgroups that best represent the data pattern...
January 18, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33414246/missing-self-and-dsa-synergy-of-two-nk-cell-activation-pathways-in-kidney-transplantation
#3
EDITORIAL
Luis G Hidalgo
No abstract text is available yet for this article.
January 7, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33414245/nbcn1-increases-nh-4-reabsorption-across-thick-ascending-limbs-the-capacity-for-urinary-nh-4-excretion-and-early-recovery-from-metabolic-acidosis
#4
Jeppe S M Olsen, Samuel Svendsen, Peder Berg, Vibeke S Dam, Mads V Sorensen, Vladimir V Matchkov, Jens Leipziger, Ebbe Boedtkjer
BACKGROUND: The electroneutral Na+ /HCO3 - cotransporter NBCn1 (Slc4a7) is expressed in basolateral membranes of renal medullary thick ascending limbs (mTALs). However, direct evidence that NBCn1 contributes to acid-base handling in mTALs, urinary net acid excretion, and systemic acid-base homeostasis has been lacking. METHODS: Metabolic acidosis was induced in wild-type and NBCn1 knockout mice. Fluorescence-based intracellular pH recordings were performed and NH4 + transport measured in isolated perfused mTALs...
January 7, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33408138/animal-model-of-pregnancy-after-acute-kidney-injury-mirrors-the-human-observations
#5
EDITORIAL
Jessica Sheehan Tangren, Ravi Thadhani
No abstract text is available yet for this article.
January 6, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33408137/adverse-maternal-and-fetal-outcomes-in-a-novel-experimental-model-of-pregnancy-after-recovery-from-renal-ischemia-reperfusion-injury
#6
Ellen E Gillis, Michael W Brands, Jennifer C Sullivan
BACKGROUND: Recent clinical studies report that women with a history of AKI have an increased incidence of maternal and fetal adverse outcomes during pregnancy, despite fully recovering renal function prior to conception. The mechanisms contributing to such adverse outcomes in pregnancy after AKI are not yet understood. METHODS: To develop a rodent model to investigate fetal and maternal outcomes in female animals with a history of AKI, we used ischemia-reperfusion injury as an experimental model of AKI in female Sprague Dawley rats...
January 6, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33397690/the-mineralocorticoid-receptor-in-salt-sensitive-hypertension-and-renal-injury
#7
REVIEW
Nobuhiro Ayuzawa, Toshiro Fujita
Hypertension and its comorbidities pose a major public health problem associated with disease-associated factors related to a modern lifestyle, such high salt intake or obesity. Accumulating evidence has demonstrated that aldosterone and its receptor, the mineralocorticoid receptor (MR), have crucial roles in the development of salt-sensitive hypertension and coexisting cardiovascular and renal injuries. Accordingly, clinical trials have repetitively shown the promising effects of MR blockers in these diseases...
January 4, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33380524/ensuring-the-equitable-advancement-of-american-kidney-health-the-need-to-account-for-socioeconomic-disparities-in-the-esrd-treatment-choices-model
#8
Yuvaram N V Reddy, Sri Lekha Tummalapalli, Mallika L Mendu
No abstract text is available yet for this article.
December 30, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33380523/new-antigens-in-membranous-nephropathy
#9
REVIEW
Sanjeev Sethi
Membranous nephropathy (MN) occurs due to deposition of immune complexes along the subepithelial region of glomerular basement membrane. Two previously identified target antigens for the immune complexes, PLA2R (identified in 2009) and THSD7A (in 2014), account for approximately 60% of all MN, both primary and secondary. In the remaining MN, target antigens were unknown. Use of laser microdissection and mass spectrometry enabled identification of new "antigens." This approach led to the identification of four novel types of MN: exotosin 1 (EXT1)- and exotosin 2 (EXT2)-associated MN, NELL1-associated MN, Sema3B-associated MN, and PCDH7-associated MN...
December 30, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33380522/trkc-is-essential-for-nephron-function-and-trans-activates-igf1r-signaling
#10
Carolin Lepa, Sascha Hoppe, Antje Stöber, Boris V Skryabin, Laura Katharina Sievers, Barbara Heitplatz, Giuliano Ciarimboli, Ute Neugebauer, Maja T Lindenmeyer, Clemens D Cohen, Hannes C A Drexler, Peter Boor, Thomas Weide, Hermann Pavenstädt, Britta George
BACKGROUND: Injury to kidney podocytes often results in chronic glomerular disease and consecutive nephron malfunction. For most glomerular diseases, targeted therapies are lacking. Thus, it is important to identify novel signaling pathways contributing to glomerular disease. Neurotrophic tyrosine kinase receptor 3 ( TrkC ) is expressed in podocytes and the protein transmits signals to the podocyte actin cytoskeleton. METHODS: Nephron-specific TrkC knockout ( TrkC-KO ) and nephron-specific TrkC -overexpressing ( TrkC-OE ) mice were generated to dissect the role of TrkC in nephron development and maintenance...
December 30, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33372009/stopping-renin-angiotensin-system-inhibitors-in-patients-with-advanced-ckd-and-risk-of-adverse-outcomes-a-nationwide-study
#11
Edouard L Fu, Marie Evans, Catherine M Clase, Laurie A Tomlinson, Merel van Diepen, Friedo W Dekker, Juan J Carrero
BACKGROUND: It is unknown whether stopping renin-angiotensin system (RAS) inhibitor therapy in patients with advanced CKD affects outcomes. METHODS: We studied patients referred to nephrologist care, listed on the Swedish Renal Registry during 2007-2017, who developed advanced CKD (eGFR<30 ml/min per 1.73 m2 ) while on RAS inhibitor therapy. Using target trial emulation techniques on the basis of cloning, censoring, and weighting, we compared the risks of stopping within 6 months and remaining off treatment versus continuing RAS inhibitor therapy...
December 28, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33443052/dysregulated-dynein-mediated-trafficking-of-nephrin-causes-inf2-related-podocytopathy
#12
Hua Sun, Chandra Perez-Gill, Johannes S Schlöndorff, Balajikarthick Subramanian, Martin R Pollak
BACKGROUND: FSGS caused by mutations in INF2 is characterized by a podocytopathy with mistrafficked nephrin, an essential component of the slit diaphragm. Because INF2 is a formin-type actin nucleator, research has focused on its actin-regulating function, providing an important but incomplete insight into how these mutations lead to podocytopathy. A yeast two-hybridization screen identified the interaction between INF2 and the dynein transport complex, suggesting a newly recognized role of INF2 in regulating dynein-mediated vesicular trafficking in podocytes...
December 22, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33443096/racial-differences-in-aki-incidence-following-percutaneous-coronary-intervention
#13
Joseph Lunyera, Robert M Clare, Karen Chiswell, Julia J Scialla, Patrick H Pun, Kevin L Thomas, Monique A Starks, Clarissa J Diamantidis
BACKGROUND: Undergoing percutaneous coronary intervention (PCI) is a risk factor for AKI development, but few studies have quantified racial differences in AKI incidence after this procedure. METHODS: We examined the association of self-reported race (Black, White, or other) and baseline eGFR with AKI incidence among patients who underwent PCI at Duke University Medical Center between January 1, 2003, and December 31, 2013. We defined AKI as a 0.3 mg/dl absolute increase in serum creatinine within 48 hours, or ≥1...
December 18, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33443079/a-randomized-clinical-trial-of-anti-il-6-antibody-clazakizumab-in-late-antibody-mediated-kidney-transplant-rejection
#14
Konstantin Doberer, Michael Duerr, Philip F Halloran, Farsad Eskandary, Klemens Budde, Heinz Regele, Jeff Reeve, Anita Borski, Nicolas Kozakowski, Roman Reindl-Schwaighofer, Johannes Waiser, Nils Lachmann, Sabine Schranz, Christa Firbas, Jakob Mühlbacher, Georg Gelbenegger, Thomas Perkmann, Markus Wahrmann, Alexander Kainz, Robin Ristl, Fabian Halleck, Gregor Bond, Edward Chong, Bernd Jilma, Georg A Böhmig
BACKGROUND: Late antibody-mediated rejection (ABMR) is a leading cause of transplant failure. Blocking IL-6 has been proposed as a promising therapeutic strategy. METHODS: We performed a phase 2 randomized pilot trial to evaluate the safety (primary endpoint) and efficacy (secondary endpoint analysis) of the anti-IL-6 antibody clazakizumab in late ABMR. The trial included 20 kidney transplant recipients with donor-specific, antibody-positive ABMR ≥365 days post-transplantation...
December 18, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33334736/long-term-exposure-to-ambient-pm-2-5-and-increased-risk-of-ckd-prevalence-in-china
#15
Guoxing Li, Jing Huang, Jinwei Wang, Minghui Zhao, Yang Liu, Xinbiao Guo, Shaowei Wu, Luxia Zhang
BACKGROUND: Fine particulate matter (PM2.5 ) is an important environmental risk factor for cardiopulmonary diseases. However, the association between PM2.5 and risk of CKD remains under-recognized, especially in regions with high levels of PM2.5 , such as China. METHODS: To explore the association between long-term exposure to ambient PM2.5 and CKD prevalence in China, we used data from the China National Survey of CKD, which included a representative sample of 47,204 adults...
December 17, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33323474/assessment-of-the-utility-of-kidney-histology-as-a-basis-for-discarding-organs-in-the-united-states-a-comparison-of-international-transplant-practices-and-outcomes
#16
Peter P Reese, Olivier Aubert, Maarten Naesens, Edmund Huang, Vishnu Potluri, Dirk Kuypers, Antoine Bouquegneau, Gillian Divard, Marc Raynaud, Yassine Bouatou, Ashley Vo, Denis Glotz, Christophe Legendre, Carmen Lefaucheur, Stanley Jordan, Jean-Philippe Empana, Xavier Jouven, Alexandre Loupy
BACKGROUND: Many kidneys donated for transplant in the United States are discarded because of abnormal histology. Whether histology adds incremental value beyond usual donor attributes in assessing allograft quality is unknown. METHODS: This population-based study included patients who received a deceased donor kidney that had been biopsied before implantation according to a prespecified protocol in France and Belgium, where preimplantation biopsy findings are generally not used for decision making in the allocation process...
December 15, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33323473/steering-transplant-immunosuppression-by-measuring-virus-specific-t-cell-levels-the-randomized-controlled-ivist-trial
#17
Thurid Ahlenstiel-Grunow, Xiaofei Liu, Raphael Schild, Jun Oh, Christina Taylan, Lutz T Weber, Hagen Staude, Murielle Verboom, Christoph Schröder, Ruxandra Sabau, Anika Großhennig, Lars Pape
BACKGROUND: Pharmacokinetic monitoring is insufficient to estimate the intensity of immunosuppression after transplantation. Virus-specific T cells correlate with both virus-specific and general cellular immune defense. Additional steering of immunosuppressive therapy by virus-specific T cell levels might optimize dosing of immunosuppressants. METHODS: In a multicenter, randomized, controlled trial, we randomized 64 pediatric kidney recipients to a control group with trough-level monitoring of immunosuppressants or to an intervention group with additional steering of immunosuppressive therapy by levels of virus-specific T cells (quantified by cytokine flow cytometry)...
December 15, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33318152/sex-specific-associations-of-sex-hormone-binding-globulin-with-ckd-and-kidney-function-a-univariable-and-multivariable-mendelian-randomization-study-in-the-uk-biobank
#18
Jie V Zhao, C Mary Schooling
BACKGROUND: Kidney function declines faster in men. Testosterone levels may mediate the sex disparity. Correspondingly, levels of sex hormone binding globulin (SHBG), which modulates sex hormones, might also be relevant to the lower kidney function in men. The sex-specific role of SHBG is unclear. METHODS: A sex-specific, Mendelian randomization (MR) study provided unconfounded estimates of SHBG levels among the United Kingdom Biobank population. Univariable MR applied 357 single nucleotide polymorphisms (SNPs) in men and 359 SNPs in women...
December 14, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33288630/humanized-c3-mouse-a-novel-accelerated-model-of-c3-glomerulopathy
#19
Kishor Devalaraja-Narashimha, Karoline Meagher, Yifan Luo, Cong Huang, Theodore Kaplan, Anantharaman Muthuswamy, Gabor Halasz, Sarah Casanova, John O'Brien, Rebecca Peyser Boiarsky, John McWhirter, Hans Gartner, Yu Bai, Scott MacDonnell, Chien Liu, Ying Hu, Adrianna Latuszek, Yi Wei, Srinivasa Prasad, Tammy Huang, George Yancopoulos, Andrew Murphy, William Olson, Brian Zambrowicz, Lynn Macdonald, Lori G Morton
BACKGROUND: C3 glomerulopathy (C3G) is characterized by the alternative-pathway (AP) hyperactivation induced by nephritic factors or complement gene mutations. Mice deficient in complement factor H (CFH) are a classic C3G model, with kidney disease that requires several months to progress to renal failure. Novel C3G models can further contribute to understanding the mechanism behind this disease and developing therapeutic approaches. METHODS: A novel, rapidly progressing, severe, murine model of C3G was developed by replacing the mouse C3 gene with the human C3 homolog using VelociGene technology...
December 7, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33288629/a-randomized-trial-of-strategies-using-darbepoetin-alfa-to-avoid-transfusions-in-ckd
#20
Robert Toto, Jeffrey Petersen, Jeffrey S Berns, Eldrin Foster Lewis, Qui Tran, Matthew R Weir
BACKGROUND: Exposure to high doses or a high cumulative dose of erythropoiesis-stimulating agents (ESAs) may contribute to cardiovascular events in patients with CKD and anemia. Whether using a low fixed ESA dose versus dosing based on a hemoglobin-based, titration-dose algorithm in such patients might reduce risks associated with high ESA doses and decrease the cumulative exposure-while reducing the need for red blood cell transfusions-is unknown. METHODS: In this phase-3, randomized trial involving 756 adults with stage-3 to -5 CKD and anemia, we evaluated incidence of red blood cell transfusions for participants randomized to receive darbepoetin given as a fixed dose (0...
December 7, 2020: Journal of the American Society of Nephrology: JASN
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