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Journal of the American Society of Nephrology : JASN

https://read.qxmd.com/read/38630537/set7-methyltransferase-and-phenotypic-switch-in-diabetic-glomerular-endothelial-cells
#1
JOURNAL ARTICLE
Scott Maxwell, Jun Okabe, Harikrishnan Kaipananickal, Hanah Rodriguez, Ishant Khurana, Keith Al-Hasani, Bryna S M Chow, Eleni Pitsillou, Tom C Karagiannis, Karin Jandeleit-Dahm, Ronald C W Ma, Yu Huang, Juliana C N Chan, Mark E Cooper, Assam El-Osta
BACKGROUND: Hyperglycaemia influences the development of glomerular endothelial cell damage and nowhere is this more evident than in the progression of diabetic kidney disease (DKD). While the Set7 lysine methyltransferase is a known hyperglycaemic sensor, its role in endothelial cell function in the context of DKD remains poorly understood. METHODS: Single-cell transcriptomics was used to investigate Set7 regulation in a mouse model of DKD, followed by validation of findings using pharmacological and shRNA inhibition of Set7...
April 17, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38625741/correction-validation-of-egfr-for-detecting-associations-between-serum-protein-biomarkers-and-subsequent-gfr-decline
#2
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 16, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38621182/cell-type-and-age-specific-expression-of-lncrnas-across-kidney-cell-types
#3
JOURNAL ARTICLE
Gyeong Dae Kim, So-I Shin, Su Woong Jung, Hyunsu An, Sin Young Choi, Minho Eun, Chang-Duk Jun, Sangho Lee, Jihwan Park
BACKGROUND: Accumulated evidence demonstrates that long non-coding RNAs (lncRNAs) regulate cell differentiation and homeostasis, influencing kidney aging and disease. Despite their versatility, the function of lncRNA remains poorly understood due to the lack of a reference map of lncRNA transcriptome in various cell types. METHODS: In this study, we employed a targeted single-cell RNA sequencing (scRNA-seq) method to enrich and characterize lncRNAs in individual cells...
April 15, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38602780/the-effects-of-pantoprazole-on-kidney-outcomes
#4
JOURNAL ARTICLE
Lonnie Pyne, Andrew Smyth, Amber O Molnar, Paul Moayyedi, Eva Muehlhofer, Salim Yusuf, John Eikelboom, Jacqueline Bosch, Michael Walsh
BACKGROUND: Observational studies have found an association between proton pump inhibitor (PPI) use and worsening kidney function. It is unclear whether these associations are causal.We conducted post-hoc analyses to determine the effect of pantoprazole on kidney function using data from the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial, a 17,598 participant randomized trial comparing pantoprazole (8,791) to placebo (8,807). METHODS: The primary outcome was the rate of change of estimated glomerular filtration rate (eGFR)...
April 11, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38598292/requiem-for-urate-lowering-in-ckd
#5
JOURNAL ARTICLE
David B Mount
No abstract text is available yet for this article.
April 10, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38593157/the-gut-microbial-metabolite-trimethylamine-n-oxide-incident-ckd-and-kidney-function-decline
#6
JOURNAL ARTICLE
Meng Wang, W H Wilson Tang, Xinmin S Li, Marcia C de Oliveira Otto, Yujin Lee, Rozenn N Lemaitre, Amanda Fretts, Ina Nemet, Nona Sotoodehnia, Colleen M Sitlani, Matthew Budoff, Joseph A DiDonato, Zeneng Wang, Nisha Bansal, Michael G Shlipak, Bruce M Psaty, David S Siscovick, Mark J Sarnak, Dariush Mozaffarian, Stanley L Hazen
BACKGROUND: Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite of dietary phosphatidylcholine and carnitine. Experimentally, TMAO causes kidney injury and tubulointerstitial fibrosis. Little is known about prospective associations between TMAO and kidney outcomes, especially incident CKD. We hypothesized that higher plasma TMAO levels would be associated with higher risk of incident CKD and greater rate of kidney function decline. METHODS: We included 10,564 participants from two community-based, prospective cohorts with estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1...
April 9, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38588568/an-innovation-ecosystem
#7
JOURNAL ARTICLE
Jonathan Himmelfarb, Buddy D Ratner
No abstract text is available yet for this article.
April 8, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38588516/consent-for-high-kidney-donor-profile-index-kidneys-the-responsibility-of-transplant-centers-to-get-it-right
#8
JOURNAL ARTICLE
Peter Stock, Charles Gerard Rickert
No abstract text is available yet for this article.
April 8, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38588514/equity-in-preemptive-kidney-transplantation-the-case-for-caution
#9
JOURNAL ARTICLE
Robert W Steiner
No abstract text is available yet for this article.
April 8, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38588513/kidney-endothelial-cell-biology-in-health-and-disease
#10
JOURNAL ARTICLE
Sargis Sedrakyan
No abstract text is available yet for this article.
April 8, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38588503/renal-intercalated-cell-differentiation-and-acid-base-regulation
#11
JOURNAL ARTICLE
Carsten A Wagner
No abstract text is available yet for this article.
April 8, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38557800/a-requiem-for-fistula-first
#12
JOURNAL ARTICLE
Michael Allon, Timmy Lee
No abstract text is available yet for this article.
April 1, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38530365/rab35-is-required-for-embryonic-development-and-kidney-and-ureter-homeostasis-through-regulation-of-epithelial-cell-junctions
#13
JOURNAL ARTICLE
Kelsey R Clearman, Napassawon Timpratoom, Dharti Patel, Addison B Rains, Courtney J Haycraft, Mandy J Croyle, Jeremy F Reiter, Bradley K Yoder
BACKGROUND: Rab35 is a member of a GTPase family of endocytic trafficking proteins. Studies in cell lines have indicated that Rab35 participates in cell adhesion, polarity, cytokinesis, and primary cilia length and composition. Additionally, sea urchin Rab35 regulates actin organization and is required for gastrulation. In mice, loss of Rab35 in the CNS disrupts hippocampal development and neuronal organization. Outside of the CNS, the functions of mammalian Rab35 in vivo are unknown...
March 26, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38530359/genome-wide-crispr-screen-identifies-phospholipid-scramblase-3-as-the-biological-target-of-mitoprotective-drug-ss-31
#14
JOURNAL ARTICLE
Josie A Silvaroli, Bijay Bisunke, Ji Young Kim, Amanda Stayton, Laura A Jayne, Shirely A Martinez, Christopher Nguyen, Prisha S Patel, Thitinee Vanichapol, Vivek Verma, Juheb Akhter, Subhashini Bolisetty, Sethu M Madhavan, Cem Kuscu, Christopher C Coss, Diana Zepeda-Orozco, Samir V Parikh, Anjali A Satoskar, Alan J Davidson, James D Eason, Hazel H Szeto, Navjot Singh Pabla, Amandeep Bajwa
BACKGROUND: The synthetic tetra-peptide SS-31 shows promise in alleviating mitochondrial dysfunction associated with common diseases. However, the precise pharmacological basis of its mitoprotective effects remains unknown. METHODS: To uncover the biological targets of SS-31, we performed a genome-scale CRISPR screen in HK-2 cells, a cell culture model where SS-31 mitigates cisplatin-associated cell death and mitochondrial dysfunction. The identified hit candidate gene was functionally validated using knockout cell lines, siRNA mediated downregulation, and tubular epithelial specific conditional knockout mice...
March 26, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38517732/gene-therapy-for-glomerular-disease
#15
JOURNAL ARTICLE
Moin Saleem
No abstract text is available yet for this article.
March 22, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38517479/decision-making-engagement-preferences-among-older-adults-with-ckd
#16
JOURNAL ARTICLE
Kristina M Gonzales, Susan Koch-Weser, Kristen Kennefick, Mary Lynch, Thalia Porteny, Hocine Tighiouart, John B Wong, Tamara Isakova, Dena E Rifkin, Elisa J Gordon, Ana Rossi, Daniel E Weiner, Keren Ladin
BACKGROUND: Older adults with kidney failure face preference-sensitive decisions regarding dialysis initiation. Despite recommendations, few older patients with kidney failure experience shared decision-making. Clinician uncertainty about the degree to which older patients prefer to engage in decision-making remains a key barrier. METHODS: Mixed-methods explanatory, longitudinal, sequential design at 4 diverse U.S. centers with patients (English-fluent, aged ≥70 years, CKD stages 4-5, nondialysis) from 2018 to 2020...
March 22, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38512269/development-and-validation-of-staging-systems-for-aa-amyloidosis
#17
JOURNAL ARTICLE
Marco Basset, Stefan O Schönland, Laura Obici, Janine Günther, Eloisa Riva, Tobias Dittrich, Paolo Milani, Virginia Valeria Ferretti, Ettore Pasquinucci, Andrea Foli, Christoph Kimmich, Martina Nanci, Claudia Bellofiore, Francesca Benigna, Jörg Beimler, Pietro Benvenuti, Francesca Fabris, Roberta Mussinelli, Mario Nuvolone, Catherine Klersy, Riccardo Albertini, Giampaolo Merlini, Ute Hegenbart, Giovanni Palladini, Norbert Blank
BACKGROUND: The kidney is involved in almost 100% of cases of AA amyloidosis, a rare disease caused by persistent inflammation with long overall survival but frequent progression to end-stage kidney failure . Identification of patients with advanced disease at diagnosis is difficult, given the absence of validated staging systems. METHODS: Newly diagnosed patients with AA amyloidosis from the Pavia (n=233, testing cohort) and Heidelberg (n=243, validation cohort) centers were included in the study...
March 21, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38502123/wwp2-regulates-kidney-fibrosis-and-the-metabolic-reprogramming-of-profibrotic-myofibroblasts
#18
JOURNAL ARTICLE
Huimei Chen, Ran You, Jing Guo, Wei Zhou, Gabriel Chew, Nithya Devapragash, Jui Zhi Loh, Loreto Gesualdo, Yanwei Li, Yuteng Jiang, Elisabeth Li Sa Tan, Shuang Chen, Paola Pontrelli, Francesco Pesce, Jacques Behmoaras, Aihua Zhang, Enrico Petretto
BACKGROUND: Renal fibrosis is a common pathological endpoint in CKD that is challenging to reverse, and myofibroblasts are responsible for the accumulation of a fibrillar collagen-rich extracellular matrix (ECM). Recent studies have unveiled myofibroblasts diversity in terms of proliferative and fibrotic characteristics, which are linked to different metabolic states. We previously demonstrated the regulation of ECM genes and tissue fibrosis by WWP2, a multifunctional E3 ubiquitin-protein ligase...
March 19, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38470444/posoleucel-in-kidney-transplant-recipients-with-bk-viremia-multicenter-randomized-double-blind-placebo-controlled-phase-2-trial
#19
JOURNAL ARTICLE
Anil Chandraker, Anil Regmi, Reginald Gohh, Akhil Sharma, E Steve Woodle, Mohammed J Ansari, Vinay Nair, Ling-Xin Chen, Tarek Alhamad, Silas Norman, Diane Cibrik, Manpreet Singh, Arnold Alper, Divya Jain, Ziad Zaky, Stuart Knechtle, Asif Sharfuddin, Gaurav Gupta, Bonnie E Lonze, Jo-Anne H Young, Deborah Adey, Arman Faravardeh, Darshana M Dadhania, Ana P Rossi, Diana Florescu, Francesca Cardarelli, Julie Ma, Sarah Gilmore, Spyridoula Vasileiou, Peter T Jindra, David Wojciechowski
No abstract text is available yet for this article.
March 12, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38447671/reduced-nephron-endowment-in-six2-tgctg-mice-is-due-to-six3-misexpression-by-aberrant-enhancer-promoter-interactions-in-the-transgene
#20
JOURNAL ARTICLE
Alison J Perl, Han Liu, Matthew Hass, Nirpesh Adhikari, Praneet Chaturvedi, Yueh-Chiang Hu, Rulang Jiang, Yaping Liu, Raphael Kopan
BACKGROUND: Lifelong kidney function relies on the complement of nephrons generated during mammalian development from a mesenchymal nephron progenitor cell population. Low nephron endowment confers increased susceptibility to chronic kidney disease. Reduced nephron numbers in the popular Six2TGC transgenic mouse line may be due to disruption of a regulatory gene at the integration site and/or ectopic expression of a gene(s) contained within the transgene. METHODS: Targeted locus amplification (TLA) was performed to identify the integration site of the Six2TGC transgene...
March 6, 2024: Journal of the American Society of Nephrology: JASN
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