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Journal of the American Society of Nephrology : JASN

https://read.qxmd.com/read/32978267/kidney-single-cell-atlas-reveals-myeloid-heterogeneity-in-progression-and-regression-of-kidney-disease
#1
Bryan R Conway, Eoin D O'Sullivan, Carolynn Cairns, James O'Sullivan, Daniel J Simpson, Angela Salzano, Katie Connor, Peng Ding, Duncan Humphries, Kevin Stewart, Oliver Teenan, Riinu Pius, Neil C Henderson, Cécile Bénézech, Prakash Ramachandran, David Ferenbach, Jeremy Hughes, Tamir Chandra, Laura Denby
BACKGROUND: Little is known about the roles of myeloid cell subsets in kidney injury and in the limited ability of the organ to repair itself. Characterizing these cells based only on surface markers using flow cytometry might not provide a full phenotypic picture. Defining these cells at the single-cell, transcriptomic level could reveal myeloid heterogeneity in the progression and regression of kidney disease. METHODS: Integrated droplet- and plate-based single-cell RNA sequencing were used in the murine, reversible, unilateral ureteric obstruction model to dissect the transcriptomic landscape at the single-cell level during renal injury and the resolution of fibrosis...
September 25, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32973085/prognostic-significance-of-ambulatory-bp-monitoring-in-ckd-a-report-from-the-chronic-renal-insufficiency-cohort-cric-study
#2
Mahboob Rahman, Xue Wang, Joshua D Bundy, Jeanne Charleston, Debbie Cohen, Jordana Cohen, Paul E Drawz, Lama Ghazi, Edward Horowitz, James P Lash, Sarah Schrauben, Matthew R Weir, Dawei Xie, Raymond R Townsend
BACKGROUND: Whether ambulatory BP monitoring is of value in evaluating risk for outcomes in patients with CKD is not clear. METHODS: We followed 1502 participants of the Chronic Renal Insufficiency Cohort (CRIC) Study for a mean of 6.72 years. We evaluated, as exposures, ambulatory BP monitoring profiles (masked uncontrolled hypertension, white-coat effect, sustained hypertension, and controlled BP), mean ambulatory BP monitoring and clinic BPs, and diurnal variation in BP-reverse dipper (higher at nighttime), nondipper, and dipper (lower at nighttime)...
September 24, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32963091/extracorporeal-treatment-for-chloroquine-hydroxychloroquine-and-quinine-poisoning-systematic-review-and-recommendations-from-the-extrip-workgroup
#3
Ingrid Berling, Joshua D King, Greene Shepherd, Robert S Hoffman, Badria Alhatali, Valery Lavergne, Darren M Roberts, Sophie Gosselin, Gabrielle Wilson, Thomas D Nolin, Marc Ghannoum
BACKGROUND: Although chloroquine, hydroxychloroquine, and quinine are used for a range of medical conditions, recent research suggested a potential role in treating COVID-19. The resultant increase in prescribing was accompanied by an increase in adverse events, including severe toxicity and death. The Extracorporeal Treatments in Poisoning (EXTRIP) workgroup sought to determine the effect of and indications for extracorporeal treatments in cases of poisoning with these drugs. METHODS: We conducted systematic reviews of the literature, screened studies, extracted data, and summarized findings following published EXTRIP methods...
September 22, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32963090/soluble-urokinase-receptor-supar-in-covid-19-related-aki
#4
Tariq U Azam, Husam R Shadid, Pennelope Blakely, Patrick O'Hayer, Hanna Berlin, Michael Pan, Peiyao Zhao, Lili Zhao, Subramaniam Pennathur, Rodica Pop-Busui, Izzet Altintas, Jens Tingleff, Marius A Stauning, Ove Andersen, Maria-Evangelia Adami, Nicky Solomonidi, Maria Tsilika, Pinkus Tober-Lau, Eleni Arnaoutoglou, Verena Keitel, Frank Tacke, Athanasios Chalkias, Sven H Loosen, Evangelos J Giamarellos-Bourboulis, Jesper Eugen-Olsen, Jochen Reiser, Salim S Hayek
BACKGROUND: AKI commonly occurs in patients with coronavirus disease 2019 (COVID-19). Its pathogenesis is poorly understood. The urokinase receptor system is a key regulator of the intersection between inflammation, immunity, and coagulation, and soluble urokinase plasminogen activator receptor (suPAR) has been identified as an immunologic risk factor for AKI. Whether suPAR is associated with COVID-19-related AKI is unknown. METHODS: In a multinational observational study of adult patients hospitalized for COVID-19, we measured suPAR levels in plasma samples from 352 adult patients that had been collected within 48 hours of admission...
September 22, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32948670/the-relationship-between-aki-and-ckd-in-patients-with-type-2-diabetes-an-observational-cohort-study
#5
Simona Hapca, Moneeza K Siddiqui, Ryan S Y Kwan, Michelle Lim, Shona Matthew, Alex S F Doney, Ewan R Pearson, Colin N A Palmer, Samira Bell
BACKGROUND: There are few observational studies evaluating the risk of AKI in people with type 2 diabetes, and even fewer simultaneously investigating AKI and CKD in this population. This limits understanding of the interplay between AKI and CKD in people with type 2 diabetes compared with the nondiabetic population. METHODS: In this retrospective, cohort study of participants with or without type 2 diabetes, we used electronic healthcare records to evaluate rates of AKI and various statistical methods to determine their relationship to CKD status and further renal function decline...
September 18, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32943491/the-mechanism-of-kidney-disease-due-to-apol1-risk-variants
#6
Etienne Pays
No abstract text is available yet for this article.
September 17, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32938650/larger-nephron-size-and-nephrosclerosis-predict-progressive-ckd-and-mortality-after-radical-nephrectomy-for-tumor-and-independent-of-kidney-function
#7
Aleksandar Denic, Hisham Elsherbiny, Aidan F Mullan, Bradley C Leibovich, R Houston Thompson, Luisa Ricaurte Archila, Ramya Narasimhan, Walter K Kremers, Mariam P Alexander, John C Lieske, Lilach O Lerman, Andrew D Rule
BACKGROUND: Nephron hypertrophy and nephrosclerosis may be important determinants of CKD and mortality. However, studies of outcomes associated with these microstructural features have been limited to small tissue specimens from patients selected for either good kidney health or known kidney disease. METHODS: To determine whether microstructural features are predictive of progressive CKD and mortality outcomes, we studied patients who underwent a radical nephrectomy for a tumor...
September 16, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32938649/synaptopodin-is-dispensable-for-normal-podocyte-homeostasis-but-is-protective-in-the-context-of-acute-podocyte-injury
#8
Liang Ning, Hani Y Suleiman, Jeffrey H Miner
BACKGROUND: Synaptopodin (Synpo) is an actin-associated protein in podocytes and dendritic spines. Many functions in regulating the actin cytoskeleton via RhoA and other pathways have been ascribed to Synpo, yet no pathogenic mutations in the SYNPO gene have been discovered in patients. Naturally occurring Synpo isoforms are known (Synpo-short and -long), and a novel truncated version (Synpo-T) is upregulated in podocytes from Synpo mutant mice. Synpo-T maintains some Synpo functions, which may prevent a podocyte phenotype from emerging in unchallenged mutant mice...
September 16, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32938648/only-hyperuricemia-with-crystalluria-but-not-asymptomatic-hyperuricemia-drives-progression-of-chronic-kidney-disease
#9
Markus Sellmayr, Moritz Roman Hernandez Petzsche, Qiuyue Ma, Nils Krüger, Helen Liapis, Andreas Brink, Barbara Lenz, Maria Lucia Angelotti, Viviane Gnemmi, Christoph Kuppe, Hyojin Kim, Eric Moniqué Johannes Bindels, Ferenc Tajti, Julio Saez-Rodriguez, Maciej Lech, Rafael Kramann, Paola Romagnani, Hans-Joachim Anders, Stefanie Steiger
BACKGROUND: The roles of asymptomatic hyperuricemia or uric acid (UA) crystals in CKD progression are unknown. Hypotheses to explain links between UA deposition and progression of CKD include that ( 1 ) asymptomatic hyperuricemia does not promote CKD progression unless UA crystallizes in the kidney; ( 2 ) UA crystal granulomas may form due to pre-existing CKD; and ( 3 ) proinflammatory granuloma-related M1-like macrophages may drive UA crystal-induced CKD progression. METHODS: MALDI-FTICR mass spectrometry, immunohistochemistry, 3D confocal microscopy, and flow cytometry were used to characterize a novel mouse model of hyperuricemia and chronic UA crystal nephropathy with granulomatous nephritis...
September 16, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32938647/reversal-of-donor-hepatitis-c-virus-related-mesangial-proliferative-gn-in-a-kidney-transplant-recipient
#10
Pascale Khairallah, Satoru Kudose, Heather K Morris, Lloyd E Ratner, Sumit Mohan, Jai Radhakrishnan, Jae-Hyung Chang
No abstract text is available yet for this article.
September 16, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32936781/the-fda-metformin-label-change-and-racial-and-sex-disparities-in-metformin-prescription-among-patients-with-ckd-injury
#11
LETTER
Mark Peter Rutkowski
No abstract text is available yet for this article.
September 11, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32936778/a-single-point-in-time-egfr-is-not-associated-with-increased-risk-of-dementia-in-the-elderly
#12
LETTER
Aditi Gupta, Jeffrey M Burns
No abstract text is available yet for this article.
September 11, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32931449/binder-blunder-in-chronic-kidney-disease
#13
EDITORIAL
Joachim H Ix
No abstract text is available yet for this article.
September 11, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32931448/authors-reply
#14
LETTER
Jung-Im Shin, Yingying Sang, Stephan C Dunning, Morgan E Grams
No abstract text is available yet for this article.
September 11, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32931447/authors-reply
#15
LETTER
Manjula Kurella Tamura, Nicholas Pajewski, Daniel E Weiner
No abstract text is available yet for this article.
September 11, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32917784/a-randomized-trial-on-the-effect-of-phosphate-reduction-on-vascular-end-points-in-ckd-improve-ckd
#16
Nigel D Toussaint, Eugenia Pedagogos, Nicole M Lioufas, Grahame J Elder, Elaine M Pascoe, Sunil V Badve, Andrea Valks, Geoffrey A Block, Neil Boudville, James D Cameron, Katrina L Campbell, Sylvia S M Chen, Randall J Faull, Stephen G Holt, Dana Jackson, Meg J Jardine, David W Johnson, Peter G Kerr, Kenneth K Lau, Lai-Seong Hooi, Om Narayan, Vlado Perkovic, Kevan R Polkinghorne, Carol A Pollock, Donna Reidlinger, Laura Robison, Edward R Smith, Robert J Walker, Angela Yee Moon Wang, Carmel M Hawley
BACKGROUND: Hyperphosphatemia is associated with increased fibroblast growth factor 23 (FGF23), arterial calcification, and cardiovascular mortality. Effects of phosphate-lowering medication on vascular calcification and arterial stiffness in CKD remain uncertain. METHODS: To assess the effects of non-calcium-based phosphate binders on intermediate cardiovascular markers, we conducted a multicenter, double-blind trial, randomizing 278 participants with stage 3b or 4 CKD and serum phosphate >1...
September 11, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32917783/effect-of-neighborhood-food-environment-and-socioeconomic-status-on-serum-phosphorus-level-for-patients-on-chronic-dialysis
#17
Vishnu S Potluri, Deirdre Sawinski, Vicky Tam, Justine Shults, Jordana B Cohen, Douglas J Wiebe, Siddharth P Shah, Jeffrey S Berns, Peter P Reese
BACKGROUND: Elevated blood phosphorus levels are common and associated with a greater risk of death for patients receiving chronic dialysis. Phosphorus-rich foods are prevalent in the American diet, and low-phosphorus foods, including fruits and vegetables, are often less available in areas with more poverty. The relative contributions of neighborhood food availability and socioeconomic status to phosphorus control in patients receiving dialysis are unknown. METHODS: Using longitudinal data from a national dialysis provider, we constructed hierarchical, linear mixed-effects models to evaluate the relationships between neighborhood food environment or socioeconomic status and serum phosphorus level among patients receiving incident dialysis...
September 11, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32912935/improving-care-for-patients-after-hospitalization-with-acute-kidney-injury
#18
Edward D Siew, Kathleen D Liu, John Bonn, Vernon Chinchilli, Laura M Dember, Timothy D Girard, Tom Greene, Adrian F Hernandez, T Alp Ikizler, Matthew T James, Kevin Kampschroer, Jeffrey B Kopp, Marla Levy, Paul M Palevsky, Neesh Pannu, Chirag R Parikh, Michael V Rocco, Samuel A Silver, Heather Thiessen-Philbrook, Ron Wald, Yining Xie, Paul L Kimmel, Robert A Star
No abstract text is available yet for this article.
September 10, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32912934/genome-wide-meta-analysis-identifies-three-novel-susceptibility-loci-and-reveals-ethnic-heterogeneity-of-genetic-susceptibility-for-iga-nephropathy
#19
Ming Li, Ling Wang, Dian-Chun Shi, Jia-Nee Foo, Zhong Zhong, Chiea-Chuen Khor, Chiara Lanzani, Lorena Citterio, Erika Salvi, Pei-Ran Yin, Jin-Xin Bei, Li Wang, Yun-Hua Liao, Jian Chen, Qin-Kai Chen, Gang Xu, Geng-Ru Jiang, Jian-Xin Wan, Meng-Hua Chen, Nan Chen, Hong Zhang, Yi-Xin Zeng, Zhi-Hong Liu, Jian-Jun Liu, Xue-Qing Yu
BACKGROUND: Eighteen known susceptibility loci for IgAN account for only a small proportion of IgAN risk. METHODS: Genome-wide meta-analysis was performed in 2628 patients and 11,563 controls of Chinese ancestry, and a replication analysis was conducted in 6879 patients and 9019 controls of Chinese descent and 1039 patients and 1289 controls of European ancestry. The data were used to assess the association of susceptibility loci with clinical phenotypes for IgAN, and to investigate genetic heterogeneity of IgAN susceptibility between the two populations...
September 10, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32908001/death-after-kidney-transplantation-an-analysis-by-era-and-time-post-transplant
#20
Tracey Ying, Bree Shi, Patrick J Kelly, Helen Pilmore, Philip A Clayton, Steven J Chadban
BACKGROUND: Mortality risk after kidney transplantation can vary significantly during the post-transplant course. A contemporary assessment of trends in all-cause and cause-specific mortality at different periods post-transplant is required to better inform patients, clinicians, researchers, and policy makers. METHODS: We included all first kidney-only transplant recipients from 1980 through 2018 from the Australia and New Zealand Dialysis and Transplant Registry...
September 9, 2020: Journal of the American Society of Nephrology: JASN
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