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Journal of the American Society of Nephrology: JASN

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https://read.qxmd.com/read/31101664/chlorthalidone-is-superior-to-potassium-citrate-in-reducing-calcium-phosphate-stones-and-increasing-bone-quality-in-hypercalciuric-stone-forming-rats
#1
Nancy S Krieger, John R Asplin, Ignacio Granja, Felix M Ramos, Courtney Flotteron, Luojing Chen, Tong Tong Wu, Marc D Grynpas, David A Bushinsky
BACKGROUND: The pathophysiology of genetic hypercalciuric stone-forming rats parallels that of human idiopathic hypercalciuria. In this model, all animals form calcium phosphate stones. We previously found that chlorthalidone, but not potassium citrate, decreased stone formation in these rats. METHODS: To test whether chlorthalidone and potassium citrate combined would reduce calcium phosphate stone formation more than either medication alone, four groups of rats were fed a fixed amount of a normal calcium and phosphorus diet, supplemented with potassium chloride (as control), potassium citrate, chlorthalidone (with potassium chloride to equalize potassium intake), or potassium citrate plus chlorthalidone...
May 17, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31097611/vasopressin-increases-urinary-acidification-via-v1a-receptors-in-collecting-duct-intercalated-cells
#2
Torsten Giesecke, Nina Himmerkus, Jens Leipziger, Markus Bleich, Taka-Aki Koshimizu, Michael Fähling, Alina Smorodchenko, Julia Shpak, Carolin Knappe, Julian Isermann, Niklas Ayasse, Katsumasa Kawahara, Jan Schmoranzer, Niclas Gimber, Alexander Paliege, Sebastian Bachmann, Kerim Mutig
BACKGROUND: Antagonists of the V1a vasopressin receptor (V1aR) are emerging as a strategy for slowing progression of CKD. Physiologically, V1aR signaling has been linked with acid-base homeostasis, but more detailed information is needed about renal V1aR distribution and function. METHODS: We used a new anti-V1aR antibody and high-resolution microscopy to investigate Va1R distribution in rodent and human kidneys. To investigate whether V1aR activation promotes urinary H+ secretion, we used a V1aR agonist or antagonist to evaluate V1aR function in vasopressin-deficient Brattleboro rats, bladder-catheterized mice, isolated collecting ducts, and cultured inner medullary collecting duct (IMCD) cells...
May 16, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31097610/authors-reply
#3
LETTER
Virginia Wang, Cynthia J Coffman, Ann M O'Hare, Matthew L Maciejewski
No abstract text is available yet for this article.
May 16, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31097609/the-primary-secondary-care-partnership-to-improve-outcomes-in-chronic-kidney-disease-psp-ckd-study-a-cluster-randomized-trial-in-primary-care
#4
Rupert W Major, Celia Brown, David Shepherd, Stephen Rogers, Warren Pickering, Graham L Warwick, Shaun Barber, Nuzhat B Ashra, Tom Morris, Nigel J Brunskill
BACKGROUND: Most patients with CKD are managed in the community. Whether nurse-led CKD management programs improve outcomes in patients with CKD in primary care is unclear. METHODS: To assess the effect of such a program on the rate of renal function decline in patients with CKD (stages 3-5) in primary care in the United Kingdom, we conducted a cluster randomized trial, the Primary-Secondary Care Partnership to Improve Outcomes in Chronic Kidney Disease study. A software program designed for the study created a data file of patients with CKD in participating practices...
May 16, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31097608/confounding-of-race-ethnicity-and-age-in-the-survival-among-veterans-obtaining-dialysis-in-va-and-non-va-settings
#5
LETTER
Guofen Yan
No abstract text is available yet for this article.
May 16, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31097607/nephrin-signaling-results-in-integrin-%C3%AE-1-activation
#6
Christopher Philipp Dlugos, Cara Picciotto, Carolin Lepa, Malte Krakow, Antje Stöber, Mee-Ling Eddy, Thomas Weide, Astrid Jeibmann, Michael P Krahn, Veerle Van Marck, Jürgen Klingauf, Andrea Ricker, Roland Wedlich-Söldner, Hermann Pavenstädt, Christian Klämbt, Britta George
BACKGROUND: Patients with certain mutations in the gene encoding the slit diaphragm protein Nephrin fail to develop functional slit diaphragms and display severe proteinuria. Many adult-onset glomerulopathies also feature alterations in Nephrin expression and function. Nephrin signals from the podocyte slit diaphragm to the Actin cytoskeleton by recruiting proteins that can interact with C3G, a guanine nucleotide exchange factor of the small GTPase Rap1. Because Rap activity affects formation of focal adhesions, we hypothesized that Nephrin transmits signals to the Integrin receptor complex, which mediates podocyte adhesion to the extracellular matrix...
May 16, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31085680/dual-inhibition-of-gastrointestinal-phosphate-absorption-more-questions-than-answers
#7
EDITORIAL
Wing-Chi G Yeung, Nigel D Toussaint, Sunil V Badve
No abstract text is available yet for this article.
May 13, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31085679/effects-of-nicotinamide-and-lanthanum-carbonate-on-serum-phosphate-and-fibroblast-growth-factor-23-in-ckd-the-combine-trial
#8
Joachim H Ix, Tamara Isakova, Brett Larive, Kalani L Raphael, Dominic S Raj, Alfred K Cheung, Stuart M Sprague, Linda F Fried, Jennifer J Gassman, John P Middleton, Michael F Flessner, Geoffrey A Block, Myles Wolf
BACKGROUND: Higher serum phosphate and fibroblast growth factor-23 (FGF23) levels may be modifiable to prevent cardiovascular disease in CKD. Short-term studies have reported modest efficacy in phosphate and FGF23 reduction with intestinal phosphate binders in CKD. METHODS: To investigate effects of lanthanum carbonate (LC; a phosphate binder) and/or nicotinamide (NAM; an inhibitor of active intestinal phosphate transport) on serum phosphate and FGF23 in stage 3b/4 CKD, we conducted a randomized trial among individuals with eGFR 20-45 ml/min per 1...
May 13, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31085678/exome-based-rare-variant-analyses-in-ckd
#9
Sophia Cameron-Christie, Charles J Wolock, Emily Groopman, Slavé Petrovski, Sitharthan Kamalakaran, Gundula Povysil, Dimitrios Vitsios, Mengqi Zhang, Jan Fleckner, Ruth E March, Sahar Gelfman, Maddalena Marasa, Yifu Li, Simone Sanna-Cherchi, Krzysztof Kiryluk, Andrew S Allen, Bengt C Fellström, Carolina Haefliger, Adam Platt, David B Goldstein, Ali G Gharavi
BACKGROUND: Studies have identified many common genetic associations that influence renal function and all-cause CKD, but these explain only a small fraction of variance in these traits. The contribution of rare variants has not been systematically examined. METHODS: We performed exome sequencing of 3150 individuals, who collectively encompassed diverse CKD subtypes, and 9563 controls. To detect causal genes and evaluate the contribution of rare variants we used collapsing analysis, in which we compared the proportion of cases and controls carrying rare variants per gene...
May 13, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31076465/mitochondria-in-sepsis-induced-aki
#10
REVIEW
Jian Sun, Jingxiao Zhang, Jiakun Tian, Grazia Maria Virzì, Kumar Digvijay, Laura Cueto, Yongjie Yin, Mitchell H Rosner, Claudio Ronco
AKI is a common clinical condition associated with the risk of developing CKD and ESKD. Sepsis is the leading cause of AKI in the intensive care unit (ICU) and accounts for nearly half of all AKI events. Patients with AKI who require dialysis have an unacceptably high mortality rate of 60%-80%. During sepsis, endothelial activation, increased microvascular permeability, changes in regional blood flow distribution with resulting areas of hypoperfusion, and hypoxemia can lead to AKI. No effective drugs to prevent or treat human sepsis-induced AKI are currently available...
May 10, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31072827/matching-human-unilateral-aki-a-reverse-translational-approach-to-investigate-kidney-recovery-after-ischemia
#11
Danielle E Soranno, Hyo-Wook Gil, Lara Kirkbride-Romeo, Christopher Altmann, John R Montford, Haichun Yang, Ani Levine, Jane Buchanan, Sarah Faubel
BACKGROUND: The duration of renal ischemia that is associated with (or leads to) renal injury in patients is uncertain, and a reverse translational research approach has been proposed to improve animal models of AKI to facilitate clinical translatability. We developed a two murine models of unilateral renal ischemia to match a recently published human study that investigated renal injury after unilateral renal ischemia during partial nephrectomy. METHODS: Eight 10-week-old C57BL/6 male mice underwent left UiAKI or sham procedure, with or without intra-operative ice packs...
May 9, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31061139/exostosin-1-exostosin-2-associated-membranous-nephropathy
#12
Sanjeev Sethi, Benjamin J Madden, Hanna Debiec, M Cristine Charlesworth, LouAnn Gross, Aishwarya Ravindran, Amber M Hummel, Ulrich Specks, Fernando C Fervenza, Pierre Ronco
BACKGROUND: In membranous nephropathy (MN), which is characterized by deposition of immune complexes along the glomerular basement membrane (GBM), phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain-containing 7A are target antigens in approximately 70% and 1%-5% of cases of primary MN, respectively. In other cases of primary MN and in secondary MN, the target antigens are unknown. METHODS: We studied 224 cases of biopsy-proven PLA2R-negative MN and 102 controls (including 47 cases of PLA2R-associated MN) in pilot and discovery cohorts...
May 6, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31061138/cpr-for-ohca-is-rarely-successful-and-what-is-success-anyway
#13
LETTER
Samantha L Gelfand, Nwamaka D Eneanya, Amanda K Leonberg-Yoo, Jeffrey S Berns
No abstract text is available yet for this article.
May 6, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31061137/authors-reply
#14
LETTER
Patrick H Pun, Matthew E Dupre, Clark Tyson, Sana M Al-Khatib, Christopher B Granger
No abstract text is available yet for this article.
May 6, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31053638/renal-perfusion-during-hemodialysis-intradialytic-blood-flow-decline-and-effects-of-dialysate-cooling
#15
Raanan Marants, Elena Qirjazi, Claire J Grant, Ting-Yim Lee, Christopher W McIntyre
BACKGROUND: Residual renal function (RRF) confers survival in patients with ESRD but declines after initiating hemodialysis. Previous research shows that dialysate cooling reduces hemodialysis-induced circulatory stress and protects the brain and heart from ischemic injury. Whether hemodialysis-induced circulatory stress affects renal perfusion, and if it can be ameliorated with dialysate cooling to potentially reduce RRF loss, is unknown. METHODS: We used renal computed tomography perfusion imaging to scan 29 patients undergoing continuous dialysis under standard (36...
May 3, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31043434/protein-o-glcnacylation-is-essential-for-the-maintenance-of-renal-energy-homeostasis-and-function-via-lipolysis-during-fasting-and-diabetes
#16
Sho Sugahara, Shinji Kume, Masami Chin-Kanasaki, Issei Tomita, Mako Yasuda-Yamahara, Kosuke Yamahara, Naoko Takeda, Norihisa Osawa, Motoko Yanagita, Shin-Ichi Araki, Hiroshi Maegawa
BACKGROUND: Energy metabolism in proximal tubular epithelial cells (PTECs) is unique, because ATP production largely depends on lipolysis in both the fed and fasting states. Furthermore, disruption of renal lipolysis is involved in the pathogenesis of diabetic tubulopathy. Emerging evidence suggests that protein O-GlcNAcylation, an intracellular nutrient-sensing system, may regulate a number of metabolic pathways according to changes in nutritional status. Although O-GlcNAcylation in PTECs has been demonstrated experimentally, its precise role in lipolysis in PTECs is unclear...
May 1, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31043433/solving-baroreceptor-mystery-role-of-piezo-ion-channels
#17
Suzanne D Burke, Jens Jordan, David G Harrison, S Ananth Karumanchi
No abstract text is available yet for this article.
May 1, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31040191/one-time-fecal-immunochemical-screening-for-advanced-colorectal-neoplasia-in-patients-with-ckd-detect-study
#18
Germaine Wong, Richard L Hope, Kirsten Howard, Jeremy R Chapman, Antoni Castells, Simon David Roger, Michael J Bourke, Petra Macaskill, Robin Turner, Gabrielle Williams, Wai Hon Lim, Charmaine E Lok, Fritz Diekmann, Nicholas B Cross, Shaundeep Sen, Richard D M Allen, Steven J Chadban, Carol A Pollock, Allison Tong, Armando Teixeira-Pinto, Jean Y H Yang, Narelle Williams, Eric Hoi Kit Au, Anh Kieu, Laura James, Jonathan C Craig
BACKGROUND: In patients with CKD, the risk of developing colorectal cancer is high and outcomes are poor. Screening using fecal immunochemical testing (FIT) is effective in reducing mortality from colorectal cancer, but performance characteristics of FIT in CKD are unknown. METHODS: To determine the detection rates and performance characteristics of FIT for advanced colorectal neoplasia (ACN) in patients with CKD, we used FIT to prospectively screen patients aged 35-74 years with CKD (stages 3-5 CKD, dialysis, and renal transplant) from 11 sites in Australia, New Zealand, Canada, and Spain...
April 30, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31040190/proximal-tubule-autophagy-differs-in-type-1-and-2-diabetes
#19
Shinsuke Sakai, Takeshi Yamamoto, Yoshitsugu Takabatake, Atsushi Takahashi, Tomoko Namba-Hamano, Satoshi Minami, Ryuta Fujimura, Hiroaki Yonishi, Jun Matsuda, Atsushi Hesaka, Isao Matsui, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Yoshitaka Isaka
BACKGROUND: Evidence of a protective role of autophagy in kidney diseases has sparked interest in autophagy as a potential therapeutic strategy. However, understanding how the autophagic process is altered in each disorder is critically important in working toward therapeutic applications. METHODS: Using cultured kidney proximal tubule epithelial cells (PTECs) and diabetic mouse models, we investigated how autophagic activity differs in type 1 versus type 2 diabetic nephropathy...
April 30, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31040189/podocyte-specific-sialylation-deficient-mice-serve-as-a-model-for-human-fsgs
#20
Kristina M Niculovic, Linda Blume, Henri Wedekind, Elina Kats, Iris Albers, Stephanie Groos, Markus Abeln, Jessica Schmitz, Esther Beuke, Jan H Bräsen, Anette Melk, Mario Schiffer, Birgit Weinhold, Anja K Münster-Kühnel
BACKGROUND: The etiology of steroid-resistant nephrotic syndrome, which manifests as FSGS, is not completely understood. Aberrant glycosylation is an often underestimated factor for pathologic processes, and structural changes in the glomerular endothelial glycocalyx have been correlated with models of nephrotic syndrome. Glycans are frequently capped by sialic acid (Sia), and sialylation's crucial role for kidney function is well known. Human podocytes are highly sialylated; however, sialylation's role in podocyte homeostasis remains unclear...
April 30, 2019: Journal of the American Society of Nephrology: JASN
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