journal

Journal of the American Society of Nephrology: JASN

journal
https://read.qxmd.com/read/31941721/racial-and-sex-disparities-in-catheter-use-and-dialysis-access-in-the-united-states-medicare-population
#1
Shipra Arya, Taylor A Melanson, Elizabeth L George, Kara A Rothenberg, Manjula Kurella Tamura, Rachel E Patzer, Jason M Hockenberry
BACKGROUND: Despite efforts to increase arteriovenous fistula and graft use, 80% of patients in the United States start hemodialysis on a central venous catheter (CVC). METHODS: To better understand in incident hemodialysis patients how sex and race/ethnicity are associated with time on a central venous catheter and transition to an arteriovenous fistula and graft, our observational cohort study analyzed US Renal Data System data for patients with incident ESKD aged ≥66 years who started hemodialysis on a CVC in July 2010 through 2013...
January 15, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31932472/the-kidney-contains-ontogenetically-distinct-dendritic-cell-and-macrophage-subtypes-throughout-development-that-differ-in-their-inflammatory-properties
#2
Natallia Salei, Stephan Rambichler, Johanna Salvermoser, Nikos E Papaioannou, Ronja Schuchert, Dalia Pakalniškytė, Na Li, Julian A Marschner, Julia Lichtnekert, Christopher Stremmel, Filippo M Cernilogar, Melanie Salvermoser, Barbara Walzog, Tobias Straub, Gunnar Schotta, Hans-Joachim Anders, Christian Schulz, Barbara U Schraml
BACKGROUND: Mononuclear phagocytes (MPs), including macrophages, monocytes, and dendritic cells (DCs), are phagocytic cells with important roles in immunity. The developmental origin of kidney DCs has been highly debated because of the large phenotypic overlap between macrophages and DCs in this tissue. METHODS: We used fate mapping, RNA sequencing, flow cytometry, confocal microscopy, and histo-cytometry to assess the origin and phenotypic and functional properties of renal DCs in healthy kidney and of DCs after cisplatin and ischemia reperfusion-induced kidney injury...
January 13, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31924670/injured-podocytes-are-sensitized-to-angiotensin-ii-induced-calcium-signaling
#3
Julia Binz-Lotter, Christian Jüngst, Markus M Rinschen, Sybille Koehler, Peter Zentis, Astrid Schauss, Bernhard Schermer, Thomas Benzing, Matthias J Hackl
BACKGROUND: Inhibition of angiotensin II (AngII) signaling, a therapeutic mainstay of glomerular kidney diseases, is thought to act primarily through regulating glomerular blood flow and reducing filtration pressure. Although extravascular actions of AngII have been suggested, a direct effect of AngII on podocytes has not been demonstrated in vivo . METHODS: To study the effects of AngII on podocyte calcium levels in vivo , we used intravital microscopy of the kidney in mice expressing the calcium indicator protein GCaMP3...
January 10, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31924669/new-paradigm-for-cytoskeletal-organization-in-podocytes-proteolytic-fragments-of-inf2-formin-function-independently-of-inf2-actin-regulatory-activity
#4
EDITORIAL
Mira Krendel, David Pruyne
No abstract text is available yet for this article.
January 10, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31924668/fsgs-causing-inf2-mutation-impairs-cleaved-inf2-n-fragment-functions-in-podocytes
#5
Balajikarthick Subramanian, Justin Chun, Chandra Perez-Gill, Paul Yan, Isaac E Stillman, Henry N Higgs, Seth L Alper, Johannes S Schlöndorff, Martin R Pollak
BACKGROUND: Mutations in the gene encoding inverted formin-2 (INF2), a member of the formin family of actin regulatory proteins, are among the most common causes of autosomal dominant FSGS. INF2 is regulated by interaction between its N-terminal diaphanous inhibitory domain (DID) and its C-terminal diaphanous autoregulatory domain (DAD). INF2 also modulates activity of other formins, such as the mDIA subfamily, and promotes stable microtubule assembly. Why the disease-causing mutations are restricted to the N terminus and how they cause human disease has been unclear...
January 10, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31919107/large-scale-whole-genome-sequencing-reveals-the-genetic-architecture-of-primary-membranoproliferative-gn-and-c3-glomerulopathy
#6
Adam P Levine, Melanie M Y Chan, Omid Sadeghi-Alavijeh, Edwin K S Wong, H Terence Cook, Sofie Ashford, Keren Carss, Martin T Christian, Matthew Hall, Claire Louise Harris, Paul McAlinden, Kevin J Marchbank, Stephen D Marks, Heather Maxwell, Karyn Megy, Christopher J Penkett, Monika Mozere, Kathleen E Stirrups, Salih Tuna, Julie Wessels, Deborah Whitehorn, Sally A Johnson, Daniel P Gale
BACKGROUND: Primary membranoproliferative GN, including complement 3 (C3) glomerulopathy, is a rare, untreatable kidney disease characterized by glomerular complement deposition. Complement gene mutations can cause familial C3 glomerulopathy, and studies have reported rare variants in complement genes in nonfamilial primary membranoproliferative GN. METHODS: We analyzed whole-genome sequence data from 165 primary membranoproliferative GN cases and 10,250 individuals without the condition (controls) as part of the National Institutes of Health Research BioResource-Rare Diseases Study...
January 9, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31919106/whole-genome-sequencing-of-finnish-type-1-diabetic-siblings-discordant-for-kidney-disease-reveals-dna-variants-associated-with-diabetic-nephropathy
#7
Jing Guo, Owen J L Rackham, Niina Sandholm, Bing He, Anne-May Österholm, Erkka Valo, Valma Harjutsalo, Carol Forsblom, Iiro Toppila, Maija Parkkonen, Qibin Li, Wenjuan Zhu, Nathan Harmston, Sonia Chothani, Miina K Öhman, Eudora Eng, Yang Sun, Enrico Petretto, Per-Henrik Groop, Karl Tryggvason
BACKGROUND: Several genetic susceptibility loci associated with diabetic nephropathy have been documented, but no causative variants implying novel pathogenetic mechanisms have been elucidated. METHODS: We carried out whole-genome sequencing of a discovery cohort of Finnish siblings with type 1 diabetes who were discordant for the presence (case) or absence (control) of diabetic nephropathy. Controls had diabetes without complications for 15-37 years. We analyzed and annotated variants at genome, gene, and single-nucleotide variant levels...
January 9, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31919105/incident-hospitalization-with-major-cardiovascular-diseases-and-subsequent-risk-of-eskd-implications-for-cardiorenal-syndrome
#8
Junichi Ishigami, Logan T Cowan, Ryan T Demmer, Morgan E Grams, Pamela L Lutsey, Juan-Jesus Carrero, Josef Coresh, Kunihiro Matsushita
BACKGROUND: Cardiorenal syndrome is a well known concept, bolstered by extensive investigations of CKD as a risk factor of cardiovascular disease. However, data on whether cardiovascular disease increases long-term risk of ESKD are sparse. METHODS: We assessed the association of incident hospitalization with major cardiovascular diseases (heart failure, atrial fibrillation, coronary heart disease, and stroke) with subsequent risk of ESKD among individuals enrolled in the Atherosclerosis Risk in Communities study; the analysis included 9047 individuals without prevalent cardiovascular disease at their fourth study visit...
January 9, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31896554/clinical-features-and-outcomes-of-immune-checkpoint-inhibitor-associated-aki-a-multicenter-study
#9
Frank B Cortazar, Zoe A Kibbelaar, Ilya G Glezerman, Ala Abudayyeh, Omar Mamlouk, Shveta S Motwani, Naoka Murakami, Sandra M Herrmann, Sandhya Manohar, Anushree C Shirali, Abhijat Kitchlu, Shayan Shirazian, Amer Assal, Anitha Vijayan, Amanda DeMauro Renaghan, David I Ortiz-Melo, Sunil Rangarajan, A Bilal Malik, Jonathan J Hogan, Alex R Dinh, Daniel Sanghoon Shin, Kristen A Marrone, Zain Mithani, Douglas B Johnson, Afrooz Hosseini, Deekchha Uprety, Shreyak Sharma, Shruti Gupta, Kerry L Reynolds, Meghan E Sise, David E Leaf
BACKGROUND: Despite increasing recognition of the importance of immune checkpoint inhibitor-associated AKI, data on this complication of immunotherapy are sparse. METHODS: We conducted a multicenter study of 138 patients with immune checkpoint inhibitor-associated AKI, defined as a ≥2-fold increase in serum creatinine or new dialysis requirement directly attributed to an immune checkpoint inhibitor. We also collected data on 276 control patients who received these drugs but did not develop AKI...
January 2, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31879336/therapeutic-myeloperoxidase-inhibition-attenuates-neutrophil-activation-anca-mediated-endothelial-damage-and-crescentic-gn
#10
Marilina Antonelou, Erik Michaëlsson, Rhys D R Evans, Chun Jing Wang, Scott R Henderson, Lucy S K Walker, Robert John Unwin, Alan D Salama
BACKGROUND: Myeloperoxidase released after neutrophil and monocyte activation can generate reactive oxygen species, leading to host tissue damage. Extracellular glomerular myeloperoxidase deposition, seen in ANCA-associated vasculitis, may enhance crescentic GN through antigen-specific T and B cell activation. Myeloperoxidase-deficient animals have attenuated GN early on, but augmented T cell responses. We investigated the effect of myeloperoxidase inhibition, using the myeloperoxidase inhibitor AZM198, to understand its potential role in treating crescentic GN...
December 26, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31871274/current-ckd-definition-takes-into-account-both-relative-and-absolute-risk
#11
LETTER
Josef Coresh, Ron T Gansevoort, Adeera Levin, Michel Jadoul
No abstract text is available yet for this article.
December 23, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31871273/chronic-kidney-disease-call-for-an-age-adapted-definition
#12
LETTER
Andrew D Rule, Kitty J Jager, Jan A J G van den Brand, Pierre Delanaye
No abstract text is available yet for this article.
December 23, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31871272/age-dependent-definition-of-ckd
#13
LETTER
Howard Trachtman
No abstract text is available yet for this article.
December 23, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31857351/safety-net-care-for-maintenance-dialysis-in-the-united-states
#14
Kevin F Erickson, Jenny I Shen, Bo Zhao, Wolfgang C Winkelmayer, Glenn M Chertow, Vivian Ho, Jay Bhattacharya
BACKGROUND: Although most American patients with ESKD become eligible for Medicare by their fourth month of dialysis, some never do. Information about where patients with limited health insurance receive maintenance dialysis has been lacking. METHODS: We identified patients initiating maintenance dialysis (2008-2015) from the US Renal Data System, defining patients as "safety-net reliant" if they were uninsured or had only Medicaid coverage at dialysis onset and had not qualified for Medicare by the fourth dialysis month...
December 19, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31852721/when-less-becomes-more-life-and-losses-without-the-roids
#15
EDITORIAL
Germaine Wong, Wai Hon Lim, Jonathan C Craig
No abstract text is available yet for this article.
December 18, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31852720/early-steroid-withdrawal-in-deceased-donor-kidney-transplant-recipients-with-delayed-graft-function
#16
Sunjae Bae, Jacqueline M Garonzik Wang, Allan B Massie, Kyle R Jackson, Mara A McAdams-DeMarco, Daniel C Brennan, Krista L Lentine, Josef Coresh, Dorry L Segev
BACKGROUND: Early steroid withdrawal (ESW) is associated with acceptable outcomes in kidney transplant (KT) recipients. Recipients with delayed graft function (DGF), however, often have a suboptimal allograft milieu, which may alter the risk/benefit equation for ESW. This may contribute to varying practices across transplant centers. METHODS: Using the Scientific Registry of Transplant Recipients, we studied 110,019 adult deceased-donor KT recipients between 2005 and 2017...
December 18, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31848294/a-randomized-trial-comparing-the-safety-adherence-and-pharmacodynamics-profiles-of-two-doses-of-sodium-bicarbonate-in-ckd-the-base-pilot-trial
#17
Kalani L Raphael, Tamara Isakova, Joachim H Ix, Dominic S Raj, Myles Wolf, Linda F Fried, Jennifer J Gassman, Cynthia Kendrick, Brett Larive, Michael F Flessner, Susan R Mendley, Thomas H Hostetter, Geoffrey A Block, Ping Li, John P Middleton, Stuart M Sprague, Donald E Wesson, Alfred K Cheung
BACKGROUND: Oral sodium bicarbonate (NaHCO3 ) may preserve kidney function in CKD, even if initiated when serum bicarbonate concentration is normal. Adequately powered trials testing this hypothesis have not been conducted, partly because the best dose for testing is unknown. METHODS: This multicenter pilot trial assessed the safety, tolerability, adherence, and pharmacodynamics of two doses of NaHCO3 over 28 weeks in adults with eGFR 20-44 or 45-59 ml/min per 1...
December 17, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31843985/clinical-relevance-of-domain-specific-phospholipase-a-2-receptor-1-antibody-levels-in-patients-with-membranous-nephropathy
#18
Linda Reinhard, Gunther Zahner, Stephan Menzel, Friedrich Koch-Nolte, Rolf A K Stahl, Elion Hoxha
BACKGROUND: Antibodies against phospholipase A2 receptor 1 (PLA2 R1) are found in 80% of patients with membranous nephropathy, and previous studies described three autoantibody-targeted PLA2 R1 epitope regions. Although anti-PLA2 R1 antibody levels are closely associated with treatment response and disease prognosis, the clinical role of epitope regions targeted by autoantibodies is unclear. METHODS: In a prospective cohort of 150 patients with newly diagnosed PLA2 R1-associated membranous nephropathy, we investigated the clinical role of epitope-recognition patterns and domain-specific PLA2 R1 antibody levels by western blot and ELISA...
December 16, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31843984/detection-of-pla2r-autoantibodies-before-the-diagnosis-of-membranous-nephropathy
#19
Peter D Burbelo, Megha Joshi, Adrija Chaturvedi, Dustin J Little, John S Thurlow, Meryl Waldman, Stephen W Olson
BACKGROUND: Circulating serum autoantibodies against the M-type phospholipase A2 receptor (PLA2R-AB) are a key biomarker in the diagnosis and monitoring of primary membranous nephropathy (MN). However, little is known about the appearance and trajectory of PLA2R-AB before the clinical diagnosis of MN. METHODS: Using the Department of Defense Serum Repository, we analyzed PLA2R-AB in multiple, 1054 longitudinal serum samples collected before diagnosis of MN from 134 individuals with primary MN, 35 individuals with secondary MN, and 134 healthy volunteers...
December 16, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31843983/loss-of-histone-h3-k79-methyltransferase-dot1l-facilitates-kidney-fibrosis-by-upregulating-endothelin-1-through-histone-deacetylase-2
#20
Long Zhang, Lihe Chen, Chao Gao, Enuo Chen, Andrea R Lightle, Llewellyn Foulke, Bihong Zhao, Paul J Higgins, Wenzheng Zhang
BACKGROUND: The progression rate of CKD varies substantially among patients. The genetic and epigenetic contributions that modify how individual patients respond to kidney injury are largely unknown. Emerging evidence has suggested that histone H3 K79 methyltransferase Dot1l has an antifibrotic effect by repressing Edn1 , which encodes endothelin 1 in the connecting tubule/collecting duct. METHODS: To determine if deletion of the Dot1l gene is a genetic and epigenetic risk factor through regulating Edn1, we studied four groups of mice: wild-type mice, connecting tubule/collecting duct-specific Dot1l conditional knockout mice ( Dot1lAC ), Dot1l and Edn1 double-knockout mice ( DEAC ), and Edn1 connecting tubule/collecting duct-specific conditional knockout mice ( Edn1AC ), under three experimental conditions (streptozotocin-induced diabetes, during normal aging, and after unilateral ureteral obstruction)...
December 16, 2019: Journal of the American Society of Nephrology: JASN
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