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Journal of the American Society of Nephrology : JASN

https://read.qxmd.com/read/33837122/reassessing-the-inclusion-of-race-in-diagnosing-kidney-diseases-an-interim-report-from-the-nkf-asn-task-force
#1
Cynthia Delgado, Mukta Baweja, Nilka Ríos Burrows, Deidra C Crews, Nwamaka D Eneanya, Crystal A Gadegbeku, Lesley A Inker, Mallika L Mendu, W Greg Miller, Marva M Moxey-Mims, Glenda V Roberts, Wendy L St Peter, Curtis Warfield, Neil R Powe
For almost two decades, equations that use serum creatinine, age, sex, and race to eGFR have included "race" as Black or non-Black. Given considerable evidence of disparities in health and healthcare delivery in African American communities, some regard keeping a race term in GFR equations as a practice that differentially influences access to care and kidney transplantation. Others assert that race captures important GFR determinants and its removal from the calculation may perpetuate other disparities...
April 9, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33837121/race-and-the-estimation-of-gfr-getting-it-right
#2
EDITORIAL
Harold I Feldman, Josephine P Briggs
No abstract text is available yet for this article.
April 9, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33833079/protocadherin-7-associated-membranous-nephropathy
#3
Sanjeev Sethi, Benjamin Madden, Hanna Debiec, Johann Morelle, M Cristine Charlesworth, LouAnn Gross, Vivian Negron, David Buob, Sidharth Chaudhry, Michel Jadoul, Fernando C Fervenza, Pierre Ronco
BACKGROUND: Membranous nephropathy (MN) results from deposition of antigen-antibody complexes along the glomerular basement membrane (GBM). PLA2R, THSD7A, NELL1, and SEMA3B account for 80%-90% of target antigens in MN. METHODS: We performed laser microdissection and mass spectrometry (MS/MS) in kidney biopsies from 135 individuals with PLA2R-negative MN, and used immunohistochemistry/immunofluorescence and confocal microscopy to confirm the MS/MS finding, detect additional cases, and localize the novel protein...
April 8, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33833078/tubuloglomerular-feedback-synchronization-in-nephrovascular-networks
#4
REVIEW
Tayyaba Zehra, William A Cupples, Branko Braam
To perform their functions, the kidneys maintain stable blood perfusion in the face of fluctuations in systemic BP. This is done through autoregulation of blood flow by the generic myogenic response and the kidney-specific tubuloglomerular feedback (TGF) mechanism. The central theme of this paper is that, to achieve autoregulation, nephrons do not work as single units to manage their individual blood flows, but rather communicate electrically over long distances to other nephrons via the vascular tree. Accordingly, we define the nephrovascular unit (NVU) to be a structure consisting of the nephron, glomerulus, afferent arteriole, and efferent arteriole...
April 8, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33833077/black-race-coefficient-in-gfr-estimation-and-diabetes-medications-in-ckd-national-estimates
#5
LETTER
Carl P Walther, Wolfgang C Winkelmayer, Sankar D Navaneethan
No abstract text is available yet for this article.
April 8, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33833076/initial-effects-of-covid-19-on-patients-with-eskd
#6
Eric D Weinhandl, James B Wetmore, Yi Peng, Jiannong Liu, David T Gilbertson, Kirsten L Johansen
BACKGROUND: Reports from around the world have indicated a fatality rate of patients with coronavirus disease 2019 (COVID-19) in the range of 20%-30% among patients with ESKD. Population-level effects of COVID-19 on patients with ESKD in the United States are uncertain. METHODS: We identified patients with ESKD from Centers for Medicare and Medicaid Services data during epidemiologic weeks 3-27 of 2017-2020 and corresponding weeks of 2017-2019, stratifying them by kidney replacement therapy...
April 8, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33827903/monkeying-about-with-nephron-formation
#7
EDITORIAL
Ian M Smyth
No abstract text is available yet for this article.
April 7, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33827902/advance-care-planning-in-older-adults-with-ckd-patient-care-partner-and-clinician-perspectives
#8
Keren Ladin, Isabel Neckermann, Noah D'Arcangelo, Susan Koch-Weser, John B Wong, Elisa J Gordon, Ana Rossi, Dena Rifkin, Tamara Isakova, Daniel E Weiner
BACKGROUND: Older patients with advanced CKD are at high risk for serious complications and death, yet few discuss advance care planning (ACP) with their kidney clinicians. Examining barriers and facilitators to ACP among such patients might help identify patient-centered opportunities for improvement. METHODS: In semistructured interviews in March through August 2019 with purposively sampled patients (aged ≥70 years, CKD stages 4-5, nondialysis), care partners, and clinicians at clinics in across the United States, participants described discussions, factors contributing to ACP completion or avoidance, and perceived value of ACP...
April 7, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33824191/kidney-transplant-rejection-clusters-and-graft-outcomes-revisiting-banff-in-the-era-of-big-data
#9
EDITORIAL
George Vasquez-Rios, Madhav C Menon
No abstract text is available yet for this article.
April 6, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33811157/defects-in-kcnj16-cause-a-novel-tubulopathy-with-hypokalemia-salt-wasting-disturbed-acid-base-homeostasis-and-sensorineural-deafness
#10
Karl P Schlingmann, Aparna Renigunta, Ewout J Hoorn, Anna-Lena Forst, Vijay Renigunta, Velko Atanasov, Sinthura Mahendran, Tahsin Stefan Barakat, Valentine Gillion, Nathalie Godefroid, Alice S Brooks, Dorien Lugtenberg, Jennifer Lake, Huguette Debaix, Christoph Rudin, Bertrand Knebelmann, Stephanie Tellier, Caroline Rousset-Rouvière, Daan Viering, Jeroen H F deBaaij, Stefanie Weber, Oleg Palygin, Alexander Staruschenko, Robert Kleta, Pascal Houillier, Detlef Bockenhauer, Olivier Devuyst, Rosa Vargas-Poussou, Richard Warth, Anselm A Zdebik, Martin Konrad
BACKGROUND: The transepithelial transport of electrolytes, solutes, and water in the kidney is a well-orchestrated process involving numerous membrane transport systems. Basolateral potassium channels in tubular cells not only mediate potassium recycling for proper Na+ ,K+ -ATPase function but are also involved in potassium and pH sensing. Genetic defects in KCNJ10 cause EAST/SeSAME syndrome, characterized by renal salt wasting with hypokalemic alkalosis associated with epilepsy, ataxia, and sensorineural deafness...
April 2, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33795426/medicaid-expansion-and-incidence-of-kidney-failure-among-nonelderly-adults
#11
Rebecca Thorsness, Shailender Swaminathan, Yoojin Lee, Benjamin D Sommers, Rajnish Mehrotra, Kevin H Nguyen, Daeho Kim, Maricruz Rivera-Hernandez, Amal N Trivedi
BACKGROUND: Low-income individuals without health insurance have limited access to health care. Medicaid expansions may reduce kidney failure incidence by improving access to chronic disease care. METHODS: Using a difference-in-differences analysis, we examined the association between Medicaid expansion status under the Affordable Care Act (ACA) and the kidney failure incidence rate among all nonelderly adults, aged 19-64 years, in the United States, from 2012 through 2018...
April 1, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33795425/pre-emptive-short-term-nicotinamide-mononucleotide-treatment-in-a-mouse-model-of-diabetic-nephropathy
#12
Itaru Yasuda, Kazuhiro Hasegawa, Yusuke Sakamaki, Hirokazu Muraoka, Takahisa Kawaguchi, Ei Kusahana, Takashi Ono, Takeshi Kanda, Hirobumi Tokuyama, Shu Wakino, Hiroshi Itoh
BACKGROUND: The activation of NAD+ -dependent deacetylase, Sirt1, by the administration of nicotinamide mononucleotide (NMN) ameliorates various aging-related diseases. METHODS: Diabetic db/db mice were treated with NMN transiently for 2 weeks and observed for effects on diabetic nephropathy (DN). RESULTS: At 14 weeks after the treatment period, NMN attenuated the increases in urinary albumin excretion in db/db mice without ameliorating hemoglobin A1c levels...
April 1, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33795424/the-basolateral-polarity-module-promotes-slit-diaphragm-formation-in-drosophila-nephrocytes-a-model-of-vertebrate-podocytes
#13
Michael Mysh, John S Poulton
BACKGROUND: Podocyte slit diaphragms (SDs) are intercellular junctions that function as size-selective filters, excluding most proteins from urine. Abnormalities in SDs cause proteinuria and nephrotic syndrome. Podocytes exhibit apicobasal polarity, which can affect fundamental aspects of cell biology, including morphology, intercellular junction formation, and asymmetric protein distribution along the plasma membrane. Apical polarity protein mutations cause nephrotic syndrome, and data suggest apical polarity proteins regulate SD formation...
April 1, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33789951/anti-cd20-mab-induced-b-cell-apoptosis-generates-t-cell-regulation-of-experimental-myeloperoxidase-anca-associated-vasculitis
#14
Poh-Yi Gan, Jonathan Dick, Kim M O'Sullivan, Virginie Oudin, Anne Cao Le, Daniel Koo Yuk Cheong, Raymond Shim, Maliha Alikhan, A Richard Kitching, Joshua D Ooi, Stephen R Holdsworth
BACKGROUND: Myeloperoxidase ANCA-associated vasculitis is a major cause of ESKD. Efficacy of anti-CD20 mAb treatment was tested in a mouse model of the disease. METHODS: MPO immunization induced anti-MPO autoimmunity, and a subnephritogenic dose of sheep anti-mouse GBM globulin triggered GN. RESULTS: Anti-CD20 mAb treatment increased the numbers and immunomodulatory capacity of MPO-specific T regulatory cells (Tregs) and attenuated T cell-mediated and humoral anti-MPO autoimmunity and GN...
March 31, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33789950/the-rhesus-macaque-serves-as-a-model-for-human-lateral-branch-nephrogenesis
#15
Meredith P Schuh, Lyan Alkhudairy, Andrew Potter, S Steven Potter, Kashish Chetal, Kairavee Thakkar, Nathan Salomonis, Raphael Kopan
BACKGROUND: Most nephrons are added in late gestation. Truncated extrauterine nephrogenesis in premature infants results in fewer nephrons and significantly increased risk for CKD in adulthood. To overcome the ethical and technical difficulties associated with studies of late-gestation human fetal kidney development, third-trimester rhesus macaques served as a model to understand lateral branch nephrogenesis (LBN) at the molecular level. METHODS: Immunostaining and 3D rendering assessed morphology...
March 31, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33785583/adam10-mediated-ectodomain-shedding-is-an-essential-driver-of-podocyte-damage
#16
Marlies Sachs, Sebastian Wetzel, Julia Reichelt, Wiebke Sachs, Lisa Schebsdat, Stephanie Zielinski, Lisa Seipold, Lukas Heintz, Stephan A Müller, Oliver Kretz, Maja Lindenmeyer, Thorsten Wiech, Tobias B Huber, Renate Lüllmann-Rauch, Stefan F Lichtenthaler, Paul Saftig, Catherine Meyer-Schwesinger
BACKGROUND: Podocytes embrace the glomerular capillaries with foot processes, which are interconnected by a specialized adherens junction to ultimately form the filtration barrier. Altered adhesion and loss are common features of podocyte injury, which could be mediated by shedding of cell-adhesion molecules through the regulated activity of cell surface-expressed proteases. A Disintegrin and Metalloproteinase 10 (ADAM10) is such a protease known to mediate ectodomain shedding of adhesion molecules, among others...
March 30, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33785582/causal-effects-of-positive-affect-life-satisfaction-depressive-symptoms-and-neuroticism-on-kidney-function-a-mendelian-randomization-study
#17
Sehoon Park, Soojin Lee, Yaerim Kim, Yeonhee Lee, Min Woo Kang, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
BACKGROUND: Further investigation of the causal effects of psychologic wellbeing on kidney function is warranted. METHODS: In this Mendelian randomization (MR) study, genetic instruments for positive affect, life satisfaction, depressive symptoms, and neuroticism were introduced from a previous genome-wide association study meta-analysis of European individuals. Summary-level MR was performed using the CKDGen data of European ancestry ( n =567,460), and additional allele score-based MR was performed in the individual-level data of White British UK Biobank participants ( n =321,024)...
March 30, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33782170/urinary-vesicles-are-they-ready-for-real-world-use
#18
EDITORIAL
Robert W Hunter, James W Dear
No abstract text is available yet for this article.
March 29, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33782169/obituary-for-robert-schrier
#19
Tomas Berl
No abstract text is available yet for this article.
March 29, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/33782168/comparing-approaches-to-normalize-quantify-and-characterize-urinary-extracellular-vesicles
#20
Charles J Blijdorp, Omar A Z Tutakhel, Thomas A Hartjes, Thierry P P van den Bosch, Martijn H van Heugten, Juan Pablo Rigalli, Rob Willemsen, Usha M Musterd-Bhaggoe, Eric R Barros, Roger Carles-Fontana, Cristian A Carvajal, Onno J Arntz, Fons A J van de Loo, Guido Jenster, Marian C Clahsen-van Groningen, Cathy A Cuevas, David Severs, Robert A Fenton, Martin E van Royen, Joost G J Hoenderop, René J M Bindels, Ewout J Hoorn
BACKGROUND: Urinary extracellular vesicles (uEVs) are a promising source for biomarker discovery, but optimal approaches for normalization, quantification, and characterization in spot urines are unclear. METHODS: Urine samples were analyzed in a water-loading study, from healthy subjects and patients with kidney disease. Urine particles were quantified in whole urine using nanoparticle tracking analysis (NTA), time-resolved fluorescence immunoassay (TR-FIA), and EVQuant, a novel method quantifying particles via gel immobilization...
March 29, 2021: Journal of the American Society of Nephrology: JASN
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