journal

Journal of the American Society of Nephrology: JASN

journal
https://read.qxmd.com/read/31704740/multicenter-randomized-controlled-trial-of-vitamin-k-antagonist-replacement-by-rivaroxaban-with-or-without-vitamin-k2-in-hemodialysis-patients-with-atrial-fibrillation-the-valkyrie-study
#1
An S De Vriese, Rogier Caluwé, Lotte Pyfferoen, Dirk De Bacquer, Koen De Boeck, Joost Delanote, Didier De Surgeloose, Piet Van Hoenacker, Bruno Van Vlem, Francis Verbeke
BACKGROUND: Vitamin K antagonists (VKAs), although commonly used to reduce thromboembolic risk in atrial fibrillation, have been incriminated as probable cause of accelerated vascular calcification (VC) in patients on hemodialysis. Functional vitamin K deficiency may further contribute to their susceptibility for VC. We investigated the effect of vitamin K status on VC progression in 132 patients on hemodialysis with atrial fibrillation treated with VKAs or qualifying for anticoagulation...
November 8, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31704739/economic-evaluation-of-extending-medicare-immunosuppressive-drug-coverage-for-kidney-transplant-recipients-in-the-current-era
#2
Matthew Kadatz, John S Gill, Jagbir Gill, Richard N Formica, Scott Klarenbach
BACKGROUND: Kidney transplant recipients must take immunosuppressant drugs to prevent rejection and maintain transplant function. Medicare coverage of immunosuppressant drugs for kidney transplant recipients ceases 36 months after transplantation, potentially increasing the risk of transplant failure. A contemporary economic analysis of extending Medicare coverage for the duration of transplant survival using current costs of immunosuppressant medications in the era of generic equivalents may inform immunosuppressant drug policy...
November 8, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31690575/periostin-promotes-cell-proliferation-and-macrophage-polarization-to-drive-repair-after-aki
#3
Raphaёl Kormann, Panagiotis Kavvadas, Sandrine Placier, Sophie Vandermeersch, Aude Dorison, Jean-Claude Dussaule, Christos E Chadjichristos, Niki Prakoura, Christos Chatziantoniou
BACKGROUND: The matricellular protein periostin has been associated with CKD progression in animal models and human biopsy specimens. Periostin functions by interacting with extracellular matrix components to drive collagen fibrillogenesis and remodeling or by signaling through cell-surface integrin receptors to promote cell adhesion, migration, and proliferation. However, its role in AKI is unknown. METHODS: We used mice with conditional tubule-specific overexpression of periostin or knockout mice lacking periostin expression in the renal ischemia-reperfusion injury model, and primary cultures of isolated tubular cells in a hypoxia-reoxygenation model...
November 5, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31685659/race-pregnancy-and-eskd
#4
EDITORIAL
Stephanie M Toth-Manikowski, Deidra C Crews
No abstract text is available yet for this article.
November 4, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31676726/prioritizing-functional-goals-as-we-rebuild-the-kidney
#5
EDITORIAL
Benjamin D Humphreys, Mark A Knepper
No abstract text is available yet for this article.
November 1, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31676725/looking-back-50-years-at-the-biology-of-mankind-in-space-the-renal-cardiovascular-fluid-shift-conundrum
#6
Leon G Fine
No abstract text is available yet for this article.
November 1, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31676724/effects-of-proximal-tubule-shortening-on-protein-excretion-in-a-lowe-syndrome-model
#7
Megan L Gliozzi, Eugenel B Espiritu, Katherine E Shipman, Youssef Rbaibi, Kimberly R Long, Nairita Roy, Andrew W Duncan, Matthew J Lazzara, Neil A Hukriede, Catherine J Baty, Ora A Weisz
BACKGROUND: Lowe syndrome (LS) is an X-linked recessive disorder caused by mutations in OCRL , which encodes the enzyme OCRL. Symptoms of LS include proximal tubule (PT) dysfunction typically characterized by low molecular weight proteinuria, renal tubular acidosis (RTA), aminoaciduria, and hypercalciuria. How mutant OCRL causes these symptoms isn't clear. METHODS: We examined the effect of deleting OCRL on endocytic traffic and cell division in newly created human PT CRISPR/Cas9 OCRL knockout cells, multiple PT cell lines treated with OCRL -targeting siRNA, and in orcl -mutant zebrafish...
November 1, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31676723/proximal-tubule-derived-amphiregulin-amplifies-and-integrates-profibrotic-egf-receptor-signals-in-kidney-fibrosis
#8
Eirini Kefaloyianni, Manikanda Raja Keerthi Raja, Julian Schumacher, Muthu Lakshmi Muthu, Vaishali Krishnadoss, Sushrut S Waikar, Andreas Herrlich
BACKGROUND: Sustained activation of EGF receptor (EGFR) in proximal tubule cells is a hallmark of progressive kidney fibrosis after AKI and in CKD. However, the molecular mechanisms and particular EGFR ligands involved are unknown. METHODS: We studied EGFR activation in proximal tubule cells and primary tubular cells isolated from injured kidneys in vitro . To determine in vivo the role of amphiregulin, a low-affinity EGFR ligand that is highly upregulated with injury, we used ischemia-reperfusion injury or unilateral ureteral obstruction in mice with proximal tubule cell-specific knockout of amphiregulin...
November 1, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31666297/a-modified-peptide-derived-from-goodpasture-autoantigen-arrested-and-attenuated-kidney-injuries-in-a-rat-model-of-anti-gbm-glomerulonephritis
#9
Yue Shi, Xiao-Yu Jia, Qiu-Hua Gu, Miao Wang, Zhao Cui, Ming-Hui Zhao
BACKGROUND: In Goodpasture disease, the noncollagenous domain 1 of the α 3 chain ( α 3NC1) of type IV collagen is the main target antigen of antibodies against glomerular basement membrane (GBM). We previously identified a nephritogenic epitope, P14 ( α 3127-148 ), that could induce crescentic nephritis in WKY rats, and defined its core motif. Designing a modified peptide, replacing critical pathogenic residues with nonpathogenic ones (on the basis of homologous regions in α 1NC1 chain of type IV collagen, known to be nonpathogenic), might provide a therapeutic option for anti-GBM GN...
October 30, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31658991/pretransplant-desensitization-with-costimulation-blockade-and-proteasome-inhibitor-reduces-dsa-and-delays-antibody-mediated-rejection-in-highly-sensitized-nonhuman-primate-kidney-transplant-recipients
#10
Brian Ezekian, Paul M Schroder, Michael S Mulvihill, Andrew Barbas, Bradley Collins, Kyle Freischlag, Janghoon Yoon, John S Yi, Felicitas Smith, Danae Olaso, Frances M Saccoccio, Sallie Permar, Alton B Farris, Jean Kwun, Stuart J Knechtle
BACKGROUND: Patients with broad HLA sensitization have poor access to donor organs, high mortality while waiting for kidney transplant, and inferior graft survival. Although desensitization strategies permit transplantation via lowering of donor-specific antibodies, the B cell-response axis from germinal center activation to plasma cell differentiation remains intact. METHODS: To investigate targeting the germinal center response and plasma cells as a desensitization strategy, we sensitized maximally MHC-mismatched rhesus pairs with two sequential skin transplants...
October 28, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31653784/pretransplant-kinetics-of-anti-hla-antibodies-in-patients-on-the-waiting-list-for-kidney-transplantation
#11
Matteo Togninalli, Daisuke Yoneoka, Antonios G A Kolios, Karsten Borgwardt, Jakob Nilsson
BACKGROUND: Patients on organ transplant waiting lists are evaluated for preexisting alloimmunity to minimize episodes of acute and chronic rejection by regularly monitoring for changes in alloimmune status. There are few studies on how alloimmunity changes over time in patients on kidney allograft waiting lists, and an apparent lack of research-based evidence supporting currently used monitoring intervals. METHODS: To investigate the dynamics of alloimmune responses directed at HLA antigens, we retrospectively evaluated data on anti-HLA antibodies measured by the single-antigen bead assay from 627 waitlisted patients who subsequently received a kidney transplant at University Hospital Zurich, Switzerland, between 2008 and 2017...
October 25, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31653783/integrin-linked-kinase-deficiency-in-collecting-duct-principal-cell-promotes-necroptosis-of-principal-cell-and-contributes-to-kidney-inflammation-and-fibrosis
#12
Ming Huang, Shuai Zhu, Huihui Huang, Jinzhao He, Kenji Tsuji, William W Jin, Dongping Xie, Onju Ham, Diane E Capen, Weining Lu, Teodor G Păunescu, Baoxue Yang, Hua A Jenny Lu
BACKGROUND: Necroptosis is a newly discovered cell death pathway that plays a critical role in AKI. The involvement of integrin-linked kinase (ILK) in necroptosis has not been studied. METHODS: We performed experiments in mice with an Ilk deletion in collecting duct (CD) principal cells (PCs), and cultured tubular epithelial cells treated with an ILK inhibitor or ILK siRNA knockdown. RESULTS: Ilk deletion in CD PCs resulted in acute tubular injury and early mortality in mice...
October 25, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31649099/think-twice-before-postponing-chronic-dialysis-in-children
#13
LETTER
Evgenia Preka, Marjolein Bonthuis, Jérôme Harambat, Kitty J Jager
No abstract text is available yet for this article.
October 24, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31649098/authors-reply
#14
LETTER
Erica Winnicki, Charles E McCulloch, Elaine Ku
No abstract text is available yet for this article.
October 24, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31611241/fistula-interventions-less-is-more
#15
EDITORIAL
Charmaine E Lok
No abstract text is available yet for this article.
October 14, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31611240/long-term-outcomes-of-arteriovenous-fistulas-with-unassisted-versus-assisted-maturation-a-retrospective-national-hemodialysis-cohort-study
#16
Timmy Lee, Joyce Zhang Qian, Yi Zhang, Mae Thamer, Michael Allon
BACKGROUND: About half of arteriovenous fistulas (AVFs) require one or more interventions before successful dialysis use, a process called assisted maturation. Previous research suggested that AVF abandonment and interventions to maintain patency after maturation may be more frequent with assisted maturation versus unassisted maturation. METHODS: Using the US Renal Data System, we retrospectively compared patients with assisted versus unassisted AVF maturation for postmaturation AVF outcomes, including functional primary patency loss (requiring intervention after achieving AVF maturation), AVF abandonment, and frequency of interventions...
October 14, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31604810/another-tool-in-the-fight-against-phosphate-toxicity-where-will-it-fit-and-what-does-it-tell-us-about-phosphate-homeostasis
#17
EDITORIAL
Eleanor Lederer
No abstract text is available yet for this article.
October 11, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31604809/in-remembrance-of-thomas-f-ferris-md-former-asn-president-1987-1988
#18
Thomas Hostetter, Karl A Nath
No abstract text is available yet for this article.
October 11, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31604808/additive-therapeutic-effects-of-mesenchymal-stem-cells-and-il-37-for-systemic-lupus-erythematosus
#19
Jianyong Xu, Jieting Chen, Wenlei Li, Wei Lian, Jieyong Huang, Baoyu Lai, Lingyun Li, Zhong Huang
BACKGROUND: Although mesenchymal stem cells (MSCs) might offer a promising strategy for treating SLE, their immunoregulatory plasticity makes their therapeutic effects unpredictable. Whether overexpressing IL-37, an IL-1 family member with immunosuppressive activity, might enhance the therapeutic effects of these cells for SLE is unknown. METHODS: We genetically modified MSCs to overexpress IL-37 and assessed their effects on immune suppression in vitro . We also evaluated the effects of such cells versus effects of various controls after transplanting them into MRL/ lpr mice (model of SLE)...
October 11, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/31601610/new-ways-of-finding-new-genes-for-old-diseases
#20
EDITORIAL
Richard N Sandford
No abstract text is available yet for this article.
October 10, 2019: Journal of the American Society of Nephrology: JASN
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