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Journal of the American Society of Nephrology : JASN

https://read.qxmd.com/read/34321252/acquired-decline-in-ultrafiltration-in-peritoneal-dialysis-the-role-of-glucose
#1
Raymond Krediet
Ultrafiltration is essential in peritoneal dialysis (PD) for maintenance of euvolemia, making ultrafiltration insufficiency preferably called ultrafiltration failure-an important complication. The mechanisms of ultrafiltration and ultrafiltration failure are more complex than generally assumed, especially after long-term treatment. Initially, ultrafiltration failure is mainly explained by a large number of perfused peritoneal microvessels, leading to a rapid decline of the crystalloid osmotic gradient, thereby decreasing aquaporin-mediated free water transport...
July 28, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34301794/missing-self-induced-microvascular-rejection-of-kidney-allografts-a-population-based-study
#2
Jasper Callemeyn, Aleksandar Senev, Maarten Coemans, Evelyne Lerut, Ben Sprangers, Dirk Kuypers, Alice Koenig, Olivier Thaunat, Marie-Paule Emonds, Maarten Naesens
BACKGROUND: Circulating anti-HLA donor-specific antibodies (HLA-DSA) are often absent in kidney transplant recipients with microvascular inflammation (MVI). Missing self, the inability of donor endothelial cells to provide HLA I-mediated signals to inhibitory killer cell Ig-like receptors (KIRs) on recipient natural killer cells, can cause endothelial damage in vitro , and has been associated with HLA-DSA-negative MVI. However, missing self's clinical importance as a nonhumoral trigger of allograft rejection remains unclear...
July 22, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34281960/transplant-biopsy-assessment-in-21st-century
#3
EDITORIAL
Andrew F Malone
No abstract text is available yet for this article.
July 19, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34281959/testing-of-worn-face-masks-for-timely-diagnosis-of-sars-cov-2-in-hemodialysis-patients
#4
Xiaoling Wang, Nadja Grobe, Zahin Haq, Ohnmar Thwin, Lemuel Rivera Fuentes, Dugan Maddux, Peter Kotanko
n/a.
July 19, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34281958/high-oxalate-concentrations-correlate-with-increased-risk-for-sudden-cardiac-death-in-dialysis-patients
#5
Anja Pfau, Theresa Ermer, Steven Coca, Maria Tio, Bernd Genser, Martin Reichel, Fredric Finkelstein, Winfried März, Christoph Wanner, Sushrut Waikar, Kai-Uwe Eckardt, Peter Aronson, Christiane Drechsler, Felix Knauf
Background The clinical significance of accumulating toxic terminal metabolites such as oxalate in kidney failure patients is not well understood. Methods To evaluate serum oxalate concentrations and risk of all-cause mortality and cardiovascular events in a cohort of kidney failure patients requiring chronic dialysis, we performed a post-hoc analysis of the randomized German Diabetes Dialysis Study (4D Study); this study included 1255 European hemodialysis patients with diabetes followed up for a median of 4 years...
July 19, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34272327/effects-of-dapagliflozin-in-stage-4-chronic-kidney-disease
#6
Glenn Chertow, Priya Vart, Niels Jongs, Robert Toto, Jose Luis Gorriz, Fan Fan Hou, John McMurray, Ricardo Correa-Rotter, Peter Rossing, C David Sjöström, Bergur Stefánsson, Anna Maria Langkilde, David Wheeler, Hiddo Heerspink
Background In the Dapagliflozin And Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized placebo-controlled trial, the sodium-glucose cotransporter 2 inhibitor dapagliflozin significantly reduced risk of kidney failure and prolonged survival in CKD patients with or without type 2 diabetes. Methods In this prespecified analysis of dapagliflozin's effects in patients with stage 4 CKD (eGFR<30 mL/min per 1.73m2) at baseline, we randomized adults with eGFR of 25-75 mL/min per 1.73m2 and urinary albumin-to-creatinine ratio of 200-5000 mg/g to receive dapagliflozin 10 mg/day or placebo...
July 16, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34266982/associations-of-community-water-lead-concentrations-with-hemoglobin-concentrations-and-erythropoietin-stimulating-agent-use-among-patients-with-advanced-ckd
#7
John Danziger, Kenneth J Mukamal, Eric Weinhandl
BACKGROUND: Although patients with kidney disease may be particularly susceptible to the adverse health effects associated with lead exposure, whether levels of lead found commonly in drinking water are associated with adverse outcomes in patients with ESKD is not known. METHODS: To investigate associations of lead in community water systems with hemoglobin concentrations and erythropoietin stimulating agent (ESA) use among incident patients with ESKD, we merged data from the Environmental Protection Agency (EPA) Safe Drinking Water Information System (documenting average 90th percentile lead concentrations in community water systems during 5 years before dialysis initiation, according to city of residence) with patient-level data from the United States Renal Data System...
July 15, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34261756/association-of-coding-variants-in-hydroxysteroid-17-beta-dehydrogenase-14-hsd17b14-with-reduced-progression-to-end-stage-kidney-disease-in-type-1-diabetes
#8
Josyf Mychaleckyj, Erkka Valo, Takaharu Ichimura, Tarunveer Ahluwalia, Christian Dina, Rachel Miller, Ivan Shabalin, Beata Gyorgy, JingJing Cao, Suna Onengut-Gumuscu, Eiichiro Satake, Adam Smiles, Jani Haukka, David-Alexandre Tregouet, Tina Costacou, Kristina O'Neil, Andrew Paterson, Carol Forsblom, Hillary Keenan, Marcus Pezzolesi, Marlon Pragnell, Andrzej Galecki, Stephen Rich, Niina Sandholm, Ronald Klein, Barbara Klein, Katalin Susztak, Trevor Orchard, Ron Korstanje, George King, Samy Hadjadj, Peter Rossing, Joseph Bonventre, Per-Henrik Groop, James Warram, Andrzej Krolewski
BACKGROUND: Rare variants in gene coding regions likely have a greater impact on disease-related phenotypes than common variants through disruption of their encoded protein. We searched for rare variants associated with onset of end stage kidney disease (ESKD) in individuals with type 1 diabetes at advanced kidney disease stage. METHODS: Gene-based exome array analysis of 15,449 genes in 5 large incidence cohorts of individuals with type 1 diabetes and proteinuria were analyzed for survival time-to-ESKD, testing the top gene in a 6th cohort (N=2,372/1,115 events all cohorts) and replicating in two retrospective case-control studies (N=1,072 cases, 752 controls)...
July 14, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34261755/erythropoietin-reduces-auto-and-allo-antibodies-by-inhibiting-t-follicular-helper-cell-differentiation
#9
Chiara Guglielmo, Sofia Bin, Chiara Cantarelli, Susan Hartzell, Andrea Angeletti, Chiara Donadei, Arun Cumpelik, Lisa Anderson, Evan Cody, Peter Sage, Gaetano La Manna, Enrico Fiaccadori, Peter Heeger, Paolo Cravedi
Background: While high affinity IgG auto- and allo-antibodies are important drivers of kidney inflammation that can result in end stage kidney disease, therapeutic approaches that effectively reduce such pathogenic antibodies remain elusive. Erythropoietin (EPO) has immunomodulatory functions, but its effects on antibody production are unknown. Methods: We assessed the impact and underlying mechanisms of EPO/EPO receptor (EPOR) signaling on primary and secondary, T cell-dependent and T-independent, antibody formation using in vitro culture systems, murine models of organ transplantation and lupus nephritis, and mice conditionally deficient for the EPOR expressed on T cells or B cells...
July 14, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34253588/considerations-in-comparing-proximal-tubule-cell-culture-models
#10
LETTER
Ora A Weisz
No abstract text is available yet for this article.
July 12, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34253587/donor-specific-antibody-is-associated-with-increased-expression-of-rejection-transcripts-in-renal-transplant-biopsies-classified-as-no-rejection
#11
Katelynn Madill-Thomsen, Georg Boehmig, Jonathan Bromberg, Gunilla Einecke, Farsad Eskandary, Gaurav Gupta, Luis Hidalgo, Marek Myslak, Ondrej Viklicky, Agnieszka Perkowska-Ptasinska, Philip Halloran
Background: Donor-specific HLA antibody (DSA) is present in many kidney transplant patients whose biopsies are classified as no-rejection (NR). We explored whether in some NR kidneys DSA has subtle effects that are not currently being recognized. Methods: We used microarrays to examine the relationship between standard-of-care DSA and rejection-related transcript increases in 1679 kidney transplant indication biopsies in the INTERCOMEX study (ClinicalTrials.gov NCT01299168), focusing on biopsies classified as NR by automatically assigned archetypal clustering...
July 12, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34253586/toward-antiracist-reimbursement-policy-in-end-stage-kidney-disease-from-equality-to-equity
#12
Kathryn Taylor, Deidra Crews
No abstract text is available yet for this article.
July 12, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34244324/biobanks-linked-to-electronic-health-records-accelerate-genomic-discovery
#13
Dana Crawford, John Sedor
n/a.
July 9, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34244326/serum-biomarkers-of-iron-stores-are-associated-with-increased-risk-of-all-cause-mortality-and-cardiovascular-events-in-nondialysis-ckd-patients-with-or-without-anemia
#14
Murilo Guedes, Daniel G Muenz, Jarcy Zee, Brian Bieber, Benedicte Stengel, Ziad A Massy, Nicolas Mansecal, Michelle M Y Wong, David M Charytan, Helmut Reichel, Sandra Waechter, Ronald L Pisoni, Bruce M Robinson, Roberto Pecoits-Filho
BACKGROUND: Approximately 30%-45% of patients with nondialysis CKD have iron deficiency. Iron therapy in CKD has focused primarily on supporting erythropoiesis. In patients with or without anemia, there has not been a comprehensive approach to estimating the association between serum biomarkers of iron stores, and mortality and cardiovascular event risks. METHODS: The study included 5145 patients from Brazil, France, the United States, and Germany enrolled in the Chronic Kidney Disease Outcomes and Practice Patterns Study, with first available transferrin saturation (TSAT) and ferritin levels as exposure variables...
July 8, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34244325/intestinal-phosphorus-absorption-in-moderate-ckd-and-healthy-adults-determined-using-a-radioisotopic-tracer
#15
Elizabeth R Stremke, Gretchen N Wiese, Sharon M Moe, Meryl E Wastney, Ranjani N Moorthi, Kathleen M Hill Gallant
BACKGROUND: Reducing intestinal phosphorus absorption is a cornerstone in CKD-MBD management. Yet, knowledge gaps include how CKD pathophysiology affects intestinal phosphorus absorption. In vivo rodent studies suggest that intestinal phosphorus absorption remains inappropriately normal in early-moderate CKD, despite declining 1,25-dihydroxyvitamin D (1,25D). We measured intestinal phosphorus absorption in patients with moderate CKD versus healthy adults using a direct radiotracer method...
July 8, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34230103/large-scale-proteomic-assessment-of-urinary-extracellular-vesicles-highlights-their-reliability-in-reflecting-protein-changes-in-the-kidney
#16
Qi Wu, Søren Poulsen, Sathish Murali, P Richard Grimm, Xiao-Tong Su, Eric Delpire, Paul Welling, David Ellison, Robert Fenton
Background: Urinary extracellular vesicles (uEVs) are secreted into urine by cells from the kidneys and urinary tract. Although changes in uEV proteins are used for quantitative assessment of protein levels in the kidney or biomarker discovery, whether they faithfully reflect (patho)physiological changes in the kidney is a matter of debate. Methods: Mass spectrometry was used to compare in an unbiased manner the correlations between protein levels in uEVs and kidney tissue from the same animal. Studies were performed on rats fed a normal or a high K+ diet...
July 6, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34230102/presence-of-sars-cov-2-antibodies-in-spent-peritoneal-dialysate
#17
LETTER
Xiaoling Wang, Nadja Grobe, Amrish Patel, Shuchita Sharma, Jaime Uribarri, Peter Kotanko
No abstract text is available yet for this article.
July 6, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34215666/antibody-status-disease-history-and-incidence-of-sars-cov-2-infection-among-patients-on-chronic-dialysis
#18
Dena Cohen, Scott Sibbel, Gilbert Marlowe, Kelsey Bludorn, Dawn Miller, Tara Kelley, Jeffrey Connaire, Amy Young, Francesca Tentori, Steven Brunelli
Background: Although reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rare among individuals with few coronavirus disease 2019 (COVID-19) risk factors, the ability of naturally acquired immunity to prevent reinfection among patients with end-stage kidney disease (ESKD) is not known. Methods: This prospective study was conducted among adults with ESKD treated with in-center hemodialysis (ICHD) in the United States. Exposure was ascribed based on the presence or absence of immunoglobulin G (IgG) against SARS-CoV-2 at baseline, and separately, a history of documented COVID-19 prior to study entry...
July 2, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34162735/urine-apol1-isoforms-reflect-plasma-derived-liver-synthesized-proteins
#19
Magnus Althage, Timothy Heinrich, Tasso Miliotis, Anna Bogstedt, Lijun Ma, Michael Gautreaux, Pamela Hicks, Nicholette Palmer, Iain MacPhee, Judith Hartleib-Geschwindner, Peter Greasley, Barry Freedman
No abstract text is available yet for this article.
June 23, 2021: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/34162734/using-both-the-fraction-and-quantity-of-donor-derived-cell-free-dna-to-detect-kidney-allograft-rejection
#20
Suphamai Bunnapradist, Piyavadee Homkrailas, Ebad Ahmed, Gordon Fehringer, Paul Billings, Hossein Tabriziani
No abstract text is available yet for this article.
June 23, 2021: Journal of the American Society of Nephrology: JASN
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