journal

Journal of the American Society of Nephrology: JASN

journal
https://read.qxmd.com/read/32646857/kidney-involvement-in-covid-19-need-for-better-definitions
#1
LETTER
Marco Delsante, Giovanni M Rossi, Ilaria Gandolfini, Serena M Bagnasco, Avi Z Rosenberg
No abstract text is available yet for this article.
July 9, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32646856/lipocalin-2-exacerbates-lupus-nephritis-by-promoting-th1-cell-differentiation
#2
Weiwei Chen, Wenchao Li, Zhuoya Zhang, Xiaojun Tang, Shufang Wu, Genhong Yao, Kang Li, Dandan Wang, Yuemei Xu, Ruihai Feng, Xiaoxiao Duan, Xiangshan Fan, Liwei Lu, WanJun Chen, Chaojun Li, Lingyun Sun
BACKGROUND: Lipocalin-2 (LCN2) is an indicator of the severity of lupus nephritis (LN) and plays a pivotal role in immune responses, but it is not known if its effect on LN pathogenesis derives from regulating the immune imbalance of T lymphocyte subsets. METHODS: The expression of LCN2 in T cells and kidneys was assessed in renal biopsies from patients with LN. We investigated the relationship between LCN2 levels and development of LN and systemic illness by injecting anti-LCN2 antibodies into MRL/ lpr mice and analyzing pristane-treated LCN2 -/- mice...
July 9, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32641397/gentamicin-induced-acute-kidney-injury-in-an-animal-model-involves-programmed-necrosis-of-the-collecting-duct
#3
Huihui Huang, William W Jin, Ming Huang, Heyu Ji, Diane E Capen, Yin Xia, Junying Yuan, Teodor G Păunescu, Hua A Jenny Lu
BACKGROUND: Gentamicin is a potent aminoglycoside antibiotic that targets gram-negative bacteria, but nephrotoxicity limits its clinical application. The cause of gentamicin-induced AKI has been attributed mainly to apoptosis of the proximal tubule cells. However, blocking apoptosis only partially attenuates gentamicin-induced AKI in animals. METHODS: Mice treated with gentamicin for 7 days developed AKI, and programmed cell death pathways were examined using pharmacologic inhibitors and in RIPK3-deficient mice...
July 8, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32641396/distinct-modes-of-balancing-glomerular-cell-proteostasis-in-mucolipidosis-type-ii-and-iii-prevent-proteinuria
#4
Wiebke Sachs, Marlies Sachs, Elke Krüger, Stephanie Zielinski, Oliver Kretz, Tobias B Huber, Anke Baranowsky, Lena Marie Westermann, Renata Voltolini Velho, Nataniel Floriano Ludwig, Timur Alexander Yorgan, Giorgia Di Lorenzo, Katrin Kollmann, Thomas Braulke, Ida Vanessa Schwartz, Thorsten Schinke, Tatyana Danyukova, Sandra Pohl, Catherine Meyer-Schwesinger
BACKGROUND: The mechanisms balancing proteostasis in glomerular cells are unknown. Mucolipidosis (ML) II and III are rare lysosomal storage disorders associated with mutations of the Golgi-resident GlcNAc-1-phosphotransferase, which generates mannose 6-phosphate residues on lysosomal enzymes. Without this modification, lysosomal enzymes are missorted to the extracellular space, which results in lysosomal dysfunction of many cell types. Patients with MLII present with severe skeletal abnormalities, multisystemic symptoms, and early death; the clinical course in MLIII is less progressive...
July 8, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32641395/transcriptional-changes-in-kidney-allografts-with-histology-of-antibody-mediated-rejection-without-anti-hla-donor-specific-antibodies
#5
Jasper Callemeyn, Evelyne Lerut, Henriette de Loor, Ingrid Arijs, Olivier Thaunat, Alice Koenig, Vannary Meas-Yedid, Jean-Christophe Olivo-Marin, Philip Halloran, Jessica Chang, Lieven Thorrez, Dirk Kuypers, Ben Sprangers, Leentje Van Lommel, Frans Schuit, Marie Essig, Wilfried Gwinner, Dany Anglicheau, Pierre Marquet, Maarten Naesens
BACKGROUND: Circulating donor-specific anti-HLA antibodies (HLA-DSAs) are often absent in serum of kidney allograft recipients whose biopsy specimens demonstrate histology of antibody-mediated rejection (ABMR). It is unclear whether cases involving ABMR histology without detectable HLA-DSAs represent a distinct clinical and molecular phenotype. METHODS: In this multicenter cohort study, we integrated allograft microarray analysis with extensive clinical and histologic phenotyping from 224 kidney transplant recipients between 2011 and 2017...
July 8, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32639939/authors-reply
#6
LETTER
Crystal Farrington, Michael Allon
No abstract text is available yet for this article.
July 6, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32636206/early-predictors-of-arteriovenous-fistula-maturation-preoperative-arterial-diameter-alone-is-not-enough
#7
LETTER
Pasquale Zamboli, Massimo Punzi, Umberto Marcello Bracale, Antonio Pisani
No abstract text is available yet for this article.
July 6, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32631974/traf3-modulation-novel-mechanism-for-the-anti-inflammatory-effects-of-the-vitamin-d-receptor-agonist-paricalcitol-in-renal-disease
#8
Sandra Rayego-Mateos, Jose Luis Morgado-Pascual, José Manuel Valdivielso, Ana Belén Sanz, Enrique Bosch-Panadero, Raúl R Rodrigues-Díez, Jesús Egido, Alberto Ortiz, Emilio González-Parra, Marta Ruiz-Ortega
BACKGROUND: CKD leads to vitamin D deficiency. Treatment with vitamin D receptor agonists (VDRAs) may have nephroprotective and anti-inflammatory actions, but their mechanisms of action are poorly understood. METHODS: Modulation of the noncanonical NF- κ B2 pathway and its component TNF receptor-associated factor 3 (TRAF3) by the VDRA paricalcitol was studied in PBMCs from patients with ESKD, cytokine-stimulated cells, and preclinical kidney injury models. RESULTS: In PBMCs isolated from patients with ESKD, TRAF3 protein levels were lower than in healthy controls...
July 6, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32631973/nephropathic-cystinosis-a-distinct-form-of-ckd-mineral-and-bone-disorder-that-provides-novel-insights-into-the-regulation-of-fgf23
#9
Pablo Florenzano, Macarena Jimenez, Carlos R Ferreira, Galina Nesterova, Mary Scott Roberts, Sri Harsha Tella, Luis Fernandez de Castro, Rachel I Gafni, Myles Wolf, Harald Jüppner, Barbara Gales, Katherine Wesseling-Perry, Daniela Markovich, William A Gahl, Isidro B Salusky, Michael T Collins
BACKGROUND: The rare lysosomal storage disease nephropathic cystinosis presents with renal Fanconi syndrome that evolves in time to CKD. Although biochemical abnormalities in common causes of CKD-mineral and bone disorder have been defined, it is unknown if persistent phosphate wasting in nephropathic cystinosis is associated with a biochemical mineral pattern distinct from that typically observed in CKD-mineral and bone disorder. METHODS: We assessed and compared determinants of mineral homeostasis in patients with nephropathic cystinosis across the predialysis CKD spectrum to these determinants in age- and CKD stage-matched patients, with causes of CKD other than nephropathic cystinosis...
July 6, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32616538/sympathetic-overactivity-in-ckd-disrupts-buffering-of-neurotransmission-by-endothelium-derived-hyperpolarizing-factor-and-enhances-vasoconstriction
#10
Wei Cao, Liling Wu, Xiaodong Zhang, Jing Zhou, Jian Wang, Zhichen Yang, Huanjuan Su, Youhua Liu, Christopher S Wilcox, Fan Fan Hou
BACKGROUND: Hypertension commonly complicates CKD. Vascular smooth muscle cells (VSMCs) of resistance arteries receive signals from the sympathetic nervous system that induce an endothelial cell (EC)-dependent anticontractile response that moderates vasoconstriction. However, the specific role of this pathway in the enhanced vasoconstriction in CKD is unknown. METHODS: A mouse model of CKD hypertension generated with 5/6-nephrectomy (5/6Nx) was used to investigate the hypothesis that an impaired anticontractile mechanism enhances sympathetic vasoconstriction...
July 2, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32616537/amphiregulin-aggravates-glomerulonephritis-via-recruitment-and-activation-of-myeloid-cells
#11
Simon Melderis, Julia Hagenstein, Matthias Tobias Warkotsch, Julien Dang, Georg Rudolf Herrnstadt, Christoph Benjamin Niehus, Katrin Neumann, Ulf Panzer, Carmen Berasain, Matias A Avila, Pierre-Louis Tharaux, Gisa Tiegs, Oliver M Steinmetz
BACKGROUND: Recent studies have identified the EGF receptor (EGFR) ligand amphiregulin (AREG) as an important mediator of inflammatory diseases. Both pro- and anti-inflammatory functions have been described, but the role of AREG in GN remains unknown. METHODS: The nephrotoxic nephritis model of GN was studied in AREG-/- mice after bone marrow transplantation, and in mice with myeloid cell-specific EGFR deficiency. Therapeutic utility of AREG neutralization was assessed...
July 2, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32639940/possible-protective-effect-of-renin-angiotensin-system-inhibitors-in-covid-19-induced-acute-kidney-injury
#12
LETTER
Chia Siang Kow, Syed Shahzad Hasan
No abstract text is available yet for this article.
July 1, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32636207/authors-reply
#13
LETTER
Daniel Batlle, Maria Jose Soler, Paul A Welling, Sundararaman Swaminathan
No abstract text is available yet for this article.
July 1, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32611589/crucial-role-of-aim-cd5l-in-the-development-of-glomerular-inflammation-in-iga-nephropathy
#14
Akiko Takahata, Satoko Arai, Emiri Hiramoto, Kento Kitada, Rina Kato, Yuko Makita, Hitoshi Suzuki, Junichiro Nakata, Kimi Araki, Toru Miyazaki, Yusuke Suzuki
BACKGROUND: IgA nephropathy (IgAN) begins with aberrant IgA deposition in glomeruli, progresses to IgM/IgG/complement codeposition, and results in chronic inflammation and glomerular damage. However, the mechanism that drives such phlogogenic cascade has been unclear. Recently, apoptosis inhibitor of macrophage (AIM) protein was shown to modulate macrophages' function in various pathologic conditions, thereby profoundly affecting the progression of renal disorders, including AKI. A spontaneous IgAN model, grouped ddY (gddY) mouse, revealed the requirement of AIM for the overall inflammatory glomerular injury following IgA deposition...
July 1, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32591439/kidney-disease-intensive-hypertension-treatment-and-risk-for-dementia-and-mild-cognitive-impairment-the-systolic-blood-pressure-intervention-trial
#15
Manjula Kurella Tamura, Sarah A Gaussoin, Nicholas M Pajewski, Gordon J Chelune, Barry I Freedman, Tanya R Gure, William E Haley, Anthony A Killeen, Suzanne Oparil, Stephen R Rapp, Dena E Rifkin, Mark Supiano, Jeff D Williamson, Daniel E Weiner
BACKGROUND: Intensively treating hypertension may benefit cardiovascular disease and cognitive function, but at the short-term expense of reduced kidney function. METHODS: We investigated markers of kidney function and the effect of intensive hypertension treatment on incidence of dementia and mild cognitive impairment (MCI) in 9361 participants in the randomized Systolic Blood Pressure Intervention Trial, which compared intensive versus standard systolic BP lowering (targeting <120 mm Hg versus <140 mm Hg, respectively)...
June 26, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32591438/obstructive-sleep-apnea-other-sleep-characteristics-and-risk-of-ckd-in-the-atherosclerosis-risk-in-communities-sleep-heart-health-study
#16
Kelsie M Full, Chandra L Jackson, Casey M Rebholz, Kunihiro Matsushita, Pamela L Lutsey
BACKGROUND: Obstructive sleep apnea may be associated with development of CKD through hypoxia, inflammation, and oxidative stress. Individuals with this sleep disorder are also at increased risk for established CKD risk factors, including obesity, hypertension, and type 2 diabetes. METHODS: We examined the association between obstructive sleep apnea, other sleep characteristics, and risk of incident CKD (stage 3 or higher) in 1525 participants (mean age, 62.5 years; 52...
June 26, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32587074/central-role-for-adipocyte-na-k-atpase-oxidant-amplification-loop-in-the-pathogenesis-of-experimental-uremic-cardiomyopathy
#17
Komal Sodhi, Xiaoliang Wang, Muhammad Aslam Chaudhry, Hari Vishal Lakhani, Mishghan Zehra, Rebecca Pratt, Athar Nawab, Cameron L Cottrill, Brian Snoad, Fang Bai, James Denvir, Jiang Liu, Juan R Sanabria, Zijian Xie, Nader G Abraham, Joseph I Shapiro
BACKGROUND: Oxidative stress in adipocyte plays a central role in the pathogenesis of obesity as well as in the associated cardiovascular complications. The putative uremic toxin indoxyl sulfate induces oxidative stress and dramatically alters adipocyte phenotype in vitro . Mice that have undergone partial nephrectomy serve as an experimental model of uremic cardiomyopathy. This study examined the effects on adipocytes of administering a peptide that reduces oxidative stress to the mouse model...
June 25, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32587073/therapeutic-effect-of-adipose-derived-mesenchymal-stem-cell-transplantation-in-reducing-restenosis-in-a-murine-angioplasty-model
#18
Chuanqi Cai, Sreenivasulu Kilari, Chenglei Zhao, Michael L Simeon, Avanish Misra, Yiqing Li, Andre J van Wijnen, Debabrata Mukhopadhyay, Sanjay Misra
BACKGROUND: Percutaneous transluminal angioplasty (PTA) is the first line of treatment for stenosis in the arteriovenous fistula (AVF) created to provide access for hemodialysis, but resenosis still occurs. Transplants of adipose-derived mesenchymal stem cells (AMSCs) labeled with green fluorescent protein (GFP) to the adventitia could reduce pro-inflammatory gene expression, possibly restoring patency in a murine model of PTA for venous stenosis. METHODS: Partial nephrectomy of male C57BL/6J mice induced CKD...
June 25, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32576601/fibroblast-growth-factor-23-and-risk-of-hospitalization-with-infection-in-chronic-kidney-disease-the-chronic-renal-insufficiency-cohort-cric-study
#19
Junichi Ishigami, Jonathan T Taliercio, Harold I Feldman, Anand Srivastava, Raymond R Townsend, Debbie L Cohen, Edward J Horwitz, Panduranga Rao, Jeanne Charleston, Jeffrey C Fink, Ana C Ricardo, James Sondheimer, Teresa K Chen, Myles Wolf, Tamara Isakova, Lawrence J Appel, Kunihiro Matsushita
BACKGROUND: Risk of infectious disease is increased among individuals with CKD. Fibroblast growth factor 23 (FGF23) is often elevated in CKD, and may impair immune function directly or indirectly through proinflammatory and vitamin D-suppressing pathways. Whether FGF23 is associated with risk of infection has not been evaluated in a CKD population. METHODS: In 3655 participants of the Chronic Renal Insufficiency Cohort study, we evaluated the association of baseline plasma levels of C-terminal FGF23 with time to first hospitalization with major infection, defined by hospital discharge with a diagnosis code for urinary tract infection, pneumonia, cellulitis/osteomyelitis, or bacteremia/septicemia...
June 23, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32576600/drug-testing-for-residual-progression-of-diabetic-kidney-disease-in-mice-beyond-therapy-with-metformin-ramipril-and-empagliflozin
#20
Manga Motrapu, Monika Katarzyna Świderska, Irene Mesas, Julian Aurelio Marschner, Yutian Lei, Laura Martinez Valenzuela, Jia Fu, Kyung Lee, Maria Lucia Angelotti, Giulia Antonelli, Paola Romagnani, Hans-Joachim Anders, Lidia Anguiano
BACKGROUND: Progression of CKD in type 2 diabetes, despite dual inhibition of sodium-glucose transporter-2 and the renin-angiotensin system, remains a concern. Bromoindirubin-3'-oxime (BIO), previously reported to promote podocyte survival and regeneration, is a candidate additional drug to elicit renoprotective effects beyond therapy with metformin, ramipril, and empagliflozin (MRE). Evaluating a drug with standard therapeutics more closely mimics the clinical setting than evaluating the drug alone...
June 23, 2020: Journal of the American Society of Nephrology: JASN
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