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Journal of the American Society of Nephrology: JASN

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https://read.qxmd.com/read/30872323/archetype-analysis-identifies-distinct-profiles-in-renal-transplant-recipients-with-transplant-glomerulopathy-associated-with-allograft-survival
#1
Olivier Aubert, Sarah Higgins, Yassine Bouatou, Daniel Yoo, Marc Raynaud, Denis Viglietti, Marion Rabant, Luis Hidalgo, Denis Glotz, Christophe Legendre, Michel Delahousse, Nikhil Shah, Banu Sis, Patricia Campbell, Michael Mengel, Xavier Jouven, Jean-Paul Duong Van Huyen, Carmen Lefaucheur, Alexandre Loupy
BACKGROUND: Transplant glomerulopathy, a common glomerular lesion observed after kidney transplant that is associated with poor prognosis, is not a specific entity but rather the end stage of overlapping disease pathways. Its heterogeneity has not been precisely characterized to date. METHODS: Our study included consecutive kidney transplant recipients from three centers in France and one in Canada who presented with a diagnosis of transplant glomerulopathy (Banff cg score ≥1 by light microscopy), on the basis of biopsies performed from January of 2004 through December of 2014...
March 14, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30867249/the-rna-protein-interactome-of-differentiated-kidney-tubular-epithelial-cells
#2
Michael Ignarski, Constantin Rill, Rainer W J Kaiser, Madlen Kaldirim, René Neuhaus, Reza Esmaillie, Xinping Li, Corinna Klein, Katrin Bohl, Maike Petersen, Christian K Frese, Martin Höhne, Ilian Atanassov, Markus M Rinschen, Katja Höpker, Bernhard Schermer, Thomas Benzing, Christoph Dieterich, Francesca Fabretti, Roman-Ulrich Müller
BACKGROUND: RNA-binding proteins (RBPs) are fundamental regulators of cellular biology that affect all steps in the generation and processing of RNA molecules. Recent evidence suggests that regulation of RBPs that modulate both RNA stability and translation may have a profound effect on the proteome. However, regulation of RBPs in clinically relevant experimental conditions has not been studied systematically. METHODS: We used RNA interactome capture, a method for the global identification of RBPs to characterize the global RNA-binding proteome (RBPome) associated with polyA-tailed RNA species in murine ciliated epithelial cells of the inner medullary collecting duct...
March 13, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30867248/author-s-reply
#3
LETTER
Haojia Wu, Yuhei Kirita, Erinn L Donnelly, Benjamin D Humphreys
No abstract text is available yet for this article.
March 13, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30867247/macula-densa-sglt1-nos1-tubuloglomerular-feedback-pathway-a-new-mechanism-for-glomerular-hyperfiltration-during-hyperglycemia
#4
Jie Zhang, Jin Wei, Shan Jiang, Lan Xu, Lei Wang, Feng Cheng, Jacentha Buggs, Hermann Koepsell, Volker Vallon, Ruisheng Liu
BACKGROUND: Glomerular hyperfiltration is common in early diabetes and is considered a risk factor for later diabetic nephropathy. We propose that sodium-glucose cotransporter 1 (SGLT1) senses increases in luminal glucose at the macula densa, enhancing generation of neuronal nitric oxide synthase (NOS1)-dependent nitric oxide (NO) in the macula densa and blunting the tubuloglomerular feedback (TGF) response, thereby promoting the rise in GFR. METHODS: We used microperfusion, micropuncture, and renal clearance of FITC-inulin to examine the effects of tubular glucose on NO generation at the macula densa, TGF, and GFR in wild-type and macula densa-specific NOS1 knockout mice...
March 13, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30867246/complementary-roles-for-single-nucleus-and-single-cell-rna-sequencing-in-kidney-disease-research
#5
LETTER
Eoin D O'Sullivan, Katie J Mylonas, Jeremy Hughes, David A Ferenbach
No abstract text is available yet for this article.
March 13, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30867245/the-other-glucose-transporter-sglt1-also-a-potential-trouble-maker-in-diabetes
#6
EDITORIAL
Mattias Carlström
No abstract text is available yet for this article.
March 13, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30858225/lrg1-promotes-diabetic-kidney-disease-progression-by-enhancing-tgf-%C3%AE-induced-angiogenesis
#7
Quan Hong, Lu Zhang, Jia Fu, Divya A Verghese, Kinsuk Chauhan, Girish N Nadkarni, Zhengzhe Li, Wenjun Ju, Matthias Kretzler, Guang-Yan Cai, Xiang-Mei Chen, Vivette D D'Agati, Steven G Coca, Detlef Schlondorff, John C He, Kyung Lee
BACKGROUND: Glomerular endothelial dysfunction and neoangiogenesis have long been implicated in the pathogenesis of diabetic kidney disease (DKD). However, the specific molecular pathways contributing to these processes in the early stages of DKD are not well understood. Our recent transcriptomic profiling of glomerular endothelial cells identified a number of proangiogenic genes that were upregulated in diabetic mice, including leucine-rich α -2-glycoprotein 1 (LRG1). LRG1 was previously shown to promote neovascularization in mouse models of ocular disease by potentiating endothelial TGF- β /activin receptor-like kinase 1 (ALK1) signaling...
March 11, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30858224/you-are-just-now-telling-us-about-this-african-american-perspectives-of-testing-for-genetic-susceptibility-to-kidney-disease
#8
Ebele M Umeukeje, Bessie A Young, Stephanie M Fullerton, Kerri Cavanaugh, Delia Owens, James G Wilson, Wylie Burke, Erika Blacksher
No abstract text is available yet for this article.
March 11, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30850439/early-acute-microvascular-kidney-transplant-rejection-in-the-absence-of-anti-hla-antibodies-is-associated-with-preformed-igg-antibodies-against-diverse-glomerular-endothelial-cell-antigens
#9
Marianne Delville, Baptiste Lamarthée, Sylvain Pagie, Sarah B See, Marion Rabant, Carole Burger, Philippe Gatault, Magali Giral, Olivier Thaunat, Nadia Arzouk, Alexandre Hertig, Marc Hazzan, Marie Matignon, Christophe Mariat, Sophie Caillard, Nassim Kamar, Johnny Sayegh, Pierre-François Westeel, Cyril Garrouste, Marc Ladrière, Vincent Vuiblet, Joseph Rivalan, Pierre Merville, Dominique Bertrand, Alain Le Moine, Jean Paul Duong Van Huyen, Anne Cesbron, Nicolas Cagnard, Olivier Alibeu, Simon C Satchell, Christophe Legendre, Emmanuel Zorn, Jean-Luc Taupin, Béatrice Charreau, Dany Anglicheau
BACKGROUND: Although anti-HLA antibodies (Abs) cause most antibody-mediated rejections of renal allografts, non-anti-HLA Abs have also been postulated to contribute. A better understanding of such Abs in rejection is needed. METHODS: We conducted a nationwide study to identify kidney transplant recipients without anti-HLA donor-specific Abs who experienced acute graft dysfunction within 3 months after transplantation and showed evidence of microvascular injury, called acute microvascular rejection (AMVR)...
March 8, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30850438/dnmt1-in-six2-progenitor-cells-is-essential-for-transposable-element-silencing-and-kidney-development
#10
Szu-Yuan Li, Jihwan Park, Yuting Guan, Kiwung Chung, Rojesh Shrestha, Matthew B Palmer, Katalin Susztak
BACKGROUND: Cytosine methylation of regulatory regions, such as promoters and enhancers, plays a key role in regulating gene expression, however, its role in kidney development has not been analyzed. METHODS: To identify functionally important epigenome-modifying enzymes and genome regions where methylation modifications are functionally important for kidney development, we performed genome-wide methylation analysis, expression profiling, and systematic genetic targeting of DNA methyltransferases ( Dnmt1 , Dnmt3a , and Dnmt3b ) and Ten-eleven translocation methylcytosine hydroxylases ( Tet2 ) in nephron progenitor cells ( Six2 Cre ) in mice...
March 8, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30846560/effects-of-hemodiafiltration-versus-conventional-hemodialysis-in-children-with-eskd-the-hdf-heart-and-height-study
#11
Rukshana Shroff, Colette Smith, Bruno Ranchin, Aysun K Bayazit, Constantinos J Stefanidis, Varvara Askiti, Karolis Azukaitis, Nur Canpolat, Ayşe Ağbaş, Helen Aitkenhead, Ali Anarat, Bilal Aoun, Daley Aofolaju, Sevcan Azime Bakkaloglu, Devina Bhowruth, Dagmara Borzych-Dużałka, Ipek Kaplan Bulut, Rainer Büscher, John Deanfield, Claire Dempster, Ali Duzova, Sandra Habbig, Wesley Hayes, Shivram Hegde, Saoussen Krid, Christoph Licht, Mieczyslaw Litwin, Mark Mayes, Sevgi Mir, Rose Nemec, Lukasz Obrycki, Fabio Paglialonga, Stefano Picca, Charlotte Samaille, Mohan Shenoy, Manish D Sinha, Brankica Spasojevic, Lynsey Stronach, Enrico Vidal, Karel Vondrák, Alev Yilmaz, Ariane Zaloszyc, Michel Fischbach, Claus Peter Schmitt, Franz Schaefer
BACKGROUND: Hypertension and cardiovascular disease are common in children undergoing dialysis. Studies suggest that hemodiafiltration (HDF) may reduce cardiovascular mortality in adults, but data for children are scarce. METHODS: The HDF, Heart and Height study is a nonrandomized observational study comparing outcomes on conventional hemodialysis (HD) versus postdilution online HDF in children. Primary outcome measures were annualized changes in carotid intima-media thickness (cIMT) SD score and height SD score...
March 7, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30846559/single-cell-rna-profiling-of-glomerular-cells-shows-dynamic-changes-in-experimental-diabetic-kidney-disease
#12
Jia Fu, Kemal M Akat, Zeguo Sun, Weijia Zhang, Detlef Schlondorff, Zhihong Liu, Thomas Tuschl, Kyung Lee, John Cijiang He
BACKGROUND: Recent single-cell RNA sequencing (scRNA-seq) analyses have offered much insight into cell-specific gene expression profiles in normal kidneys. However, in diseased kidneys, understanding of changes in specific cells, particularly glomerular cells, remains limited. METHODS: To elucidate the glomerular cell-specific gene expression changes in diabetic kidney disease, we performed scRNA-seq analysis of isolated glomerular cells from streptozotocin-induced diabetic endothelial nitric oxide synthase (eNOS)-deficient (eNOS-/- ) mice and control eNOS-/- mice...
March 7, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30846558/expanding-the-patient-s-voice-in-nephrology-with-patient-reported-outcomes
#13
John D Peipert, Ron D Hays
No abstract text is available yet for this article.
March 7, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30846557/efficacy-and-safety-of-tenapanor-in-patients-with-hyperphosphatemia-receiving-maintenance-hemodialysis-a-randomized-phase-3-trial
#14
Geoffrey A Block, David P Rosenbaum, Andrew Yan, Glenn M Chertow
BACKGROUND: Guidelines recommend reducing elevated serum phosphate in patients with CKD. Tenapanor, a minimally absorbed inhibitor of gastrointestinal sodium/hydrogen exchanger 3 (NHE3), reduces paracellular phosphate transport. METHODS: In this phase 3 randomized, double-blind trial, we randomly assigned patients with hyperphosphatemia receiving maintenance hemodialysis to receive twice-daily oral tenapanor (3, 10, or 30 mg [the latter down-titrated, if needed]) for 8 weeks...
March 7, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30782597/staying-the-course-through-end-of-life-in-esrd
#15
Erica Perry, Sally Joy, Richard Swartz
No abstract text is available yet for this article.
February 19, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30782596/lower-extremity-amputation-and-health-care-utilization-in-the-last-year-of-life-among-medicare-beneficiaries-with-esrd
#16
Catherine R Butler, Margaret L Schwarze, Ronit Katz, Susan M Hailpern, William Kreuter, Yoshio N Hall, Maria E Montez Rath, Ann M O'Hare
BACKGROUND: Lower extremity amputation is common among patients with ESRD, and often portends a poor prognosis. However, little is known about end-of-life care among patients with ESRD who undergo amputation. METHODS: We conducted a mortality follow-back study of Medicare beneficiaries with ESRD who died in 2002 through 2014 to analyze patterns of lower extremity amputation in the last year of life compared with a parallel cohort of beneficiaries without ESRD. We also examined the relationship between amputation and end-of-life care among the patients with ESRD...
February 19, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30765426/overall-and-site-specific-cancer-mortality-in-patients-on-dialysis-and-after-kidney-transplant
#17
Eric H Au, Jeremy R Chapman, Jonathan C Craig, Wai H Lim, Armando Teixeira-Pinto, Shahid Ullah, Stephen McDonald, Germaine Wong
Background Patients with ESRD have a substantially increased cancer risk, but few studies have examined the patterns of cancer mortality along a patient's journey from dialysis to transplantation. METHODS: We identified all Australian patients on dialysis and patients with transplants from 1980 to 2014 from the Australia and New Zealand Dialysis and Transplant Registry. Using standardized mortality ratios (SMRs), we compared cancer mortality among patients on dialysis and patients with transplants versus the general population (overall and by age, sex, year, and site); we also performed a subgroup analysis excluding patients with preexisting cancers...
February 14, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30760499/letter-to-the-editor
#18
LETTER
Meyer D Lifschitz
No abstract text is available yet for this article.
February 13, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30760498/long-range-chromatin-interactions-in-the-kidney
#19
EDITORIAL
Yuting Guan, Hongbo Liu, Katalin Susztak
No abstract text is available yet for this article.
February 13, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30760497/authors-reply
#20
LETTER
Bryan T Haddock, Henrik Larsson, Ulrik Andersen
No abstract text is available yet for this article.
February 13, 2019: Journal of the American Society of Nephrology: JASN
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