Shi Yu Chan, Xi Zhen Low, Zhen Ming Ngoh, Zi Yan Ong, Michelle Z L Kee, Pei Huang, Shivaram Kumar, Anne Rifkin-Graboi, Yap-Seng Chong, Helen Chen, Kok Hian Tan, Jerry K Y Chan, Marielle V Fortier, Peter D Gluckman, Juan Helen Zhou, Michael J Meaney, Ai Peng Tan
OBJECTIVE: Maternal stress influences in-utero brain development and is a modifiable risk factor for offspring psychopathologies. Reward circuitry dysfunction underlies various internalizing and externalizing psychopathologies. This study examined (1) the association between maternal stress and microstructural characteristics of the neonatal nucleus accumbens (NAcc), a major node of the reward circuitry and (2) whether neonatal NAcc microstructure modulates individual susceptibility to maternal stress in relation to childhood behavioral problems...
February 21, 2024: Journal of the American Academy of Child and Adolescent Psychiatry