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Journals Journal of Allergy and Clinica...

Journal of Allergy and Clinical Immunology

https://read.qxmd.com/read/38763171/new-light-on-an-old-syndrome-role-of-api-g-7-in-mugwort-pollen-related-celery-allergy
#21
JOURNAL ARTICLE
Barbara K Ballmer-Weber, Andrea Wangorsch, Peter Bures, Kay-Martin Hanschmann, Gabriele Gadermaier, Lars Mattsson, Clare Mills, Ronald van Ree, Jonas Lidholm, Stefan Vieths
BACKGROUND: Celery root is known to cause severe allergic reactions in patients sensitized to mugwort pollen. OBJECTIVE: To study clinically well-characterized patients with celery allergy by IgE testing with a comprehensive panel of celery allergens to disentangle the molecular basis of the "celery-mugwort-syndrome". METHODS: Patients with suspected food allergy to celery underwent a standardized interview. Main inclusion criteria were a positive food challenge with celery or an unambiguous case history of severe anaphylaxis...
May 17, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38763170/clinical-and-humoral-responses-after-sars-cov-2-breakthrough-infections-in-patients-with-immunosuppressants
#22
JOURNAL ARTICLE
Eileen W Stalman, Luuk Wieske, Jim B D Keijser, Koos P J van Dam, Laura Y L Kummer, Maarten F Wilbrink, Zoé L E van Kempen, Joep Killestein, Adriaan G Volkers, Sander W Tas, Laura Boekel, Gerrit J Wolbink, Anneke J van der Kooi, Joost Raaphorst, Mark Löwenberg, R Bart Takkenberg, Geert R A M D'Haens, Phyllis I Spuls, Marcel W Bekkenk, Annelie H Musters, Nicoline F Post, Angela L Bosma, Marc L Hilhorst, Yosta Vegting, Frederique J Bemelman, Alexandre E Voskuyl, Bo Broens, Agner Parra Sanchez, Cécile A C M van Els, Jelle de Wit, Abraham Rutgers, Karina de Leeuw, Barbara Horváth, Jan J G M Verschuuren, Annabel M Ruiter, Lotte van Ouwerkerk, Diane van der Woude, Renée C F Allaart, Y K Onno Teng, Pieter van Paassen, Matthias H Busch, Esther Brusse, Pieter A van Doorn, Adája E Baars, Dirkjan Hijnen, Corine R G Schreurs, W Ludo van der Pol, H Stephan Goedee, Maurice Steenhuis, Sofie Keijzer, Olvi Cristianawati, Anja Ten Brinke, Niels J M Verstegen, Koos A H Zwinderman, S Marieke van Ham, Theo Rispens, Matthijs R Welkers, Marcel Jonges, Filip Eftimov, Taco W Kuijpers
BACKGROUND: Despite impaired humoral responses in patients treated with immunosuppressants (ISPs), recent studies found similar severity of SARS-CoV-2 breakthrough infections compared to controls. One potential explanation is the rapid generation humoral responses upon infection, but evidence is lacking. OBJECTIVES: To investigate longitudinal dynamics of the SARS-CoV-2 antibody repertoire after SARS-CoV-2 delta and omicron breakthrough infections in patients with immune-mediated inflammatory diseases (IMID) on ISPs and controls...
May 17, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38761999/exploring-the-skin-microbiome-in-atopic-dermatitis-pathogenesis-and-disease-modification
#23
REVIEW
Claudia Hülpüsch, Robin Rohayem, Matthias Reiger, Claudia Traidl-Hoffmann
Inflammatory skin diseases, like atopic eczema (atopic dermatitis, AD), affect children and adults globally. In AD, the skin barrier is impaired on multiple levels. Underlying factors include genetic, chemical, immunological, and microbial components. Increased skin pH in AD is part of the altered microbial microenvironment that promotes overgrowth of the skin microbiome with Staphylococcus aureus (S. aureus). The secretion of virulence factors, like toxins and proteases, by S. aureus further aggravates the skin barrier deficiency and additionally off-balances the already skewed immune response...
May 16, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38761998/sirt5-exacerbates-eosinophilic-chronic-rhinosinusitis-through-promoting-polarization-of-m2-macrophage
#24
JOURNAL ARTICLE
Xu-Dong Cha, Qing-Yun Zou, Feng-Zhen Li, Tian-Yu Wang, Sheng-Lei Wang, Bo-Yu Cai, Zhi-Wen Cao, Zhen-Hua Ji, Hai-Bin Liu, Wen-Wen Wang, Teng-Fei Li, Cai-Quan Liang, Wen-Wen Ren, Huan-Hai Liu
BACKGROUND: Previous study implied that local M2 polarization of macrophage promoted mucosal edema and exacerbates Th2 type inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the specific pathogenic role of M2 macrophages and the intrinsic regulators in the development of CRS remains elusive. OBJECTIVE: We thought to investigate the regulatory role of SIRT5 in the polarization of M2 macrophages and its potential contribution to the development of CRSwNP...
May 16, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38761997/a-novel-syndrome-of-silent-rhinovirus-associated-bronchoalveolitis-in-children-with-recurrent-wheeze
#25
JOURNAL ARTICLE
W Gerald Teague, Cameron D Griffiths, Kelly Boyd, Stella C Kellams, Monica Lawrence, Thomas L Offerle, Peter Heymann, William Brand, Ariana Greenwell, Jeremy Middleton, Kristin Wavell, Jacqueline Payne, Marthajoy Spano, Elaine Etter, Brittany Wall, Larry Borish
BACKGROUND: Rhinovirus (RV) infections trigger wheeze episodes in children. Thus, understanding of the lung inflammatory response to RV in children with wheeze is important. OBJECTIVE: To examine the associations of RV on lung lavage (BAL) granulocyte patterns and biomarkers of inflammation with age in children with treatment-refractory, recurrent wheeze (n=616). METHODS: Children underwent BAL to examine viral nucleic acid sequences, bacterial cultures, granulocyte counts, and phlebotomy for both general and type-2 inflammatory markers...
May 16, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38761996/the-coming-of-age-of-protein-degraders-as-anti-inflammatory-therapeutics
#26
EDITORIAL
Johann E Gudjonsson, Stephan Weidinger, Kenji Kabashima
No abstract text is available yet for this article.
May 16, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38761995/type-2-t-helper-cell-driven-manifestations-of-inborn-errors-of-immunity
#27
REVIEW
Alyssa E James, Manar Abdalgani, Paneez Khoury, Alexandra F Freeman, Joshua D Milner
Monogenic lesions in pathways critical for effector functions responsible for immune surveillance, protection against autoinflammation and appropriate responses to allergens and microorganisms underlie the pathophysiology of inborn errors of immunity (IEI). Variants in cytokine production, cytokine signaling, epithelial barrier function, antigen presentation, receptor signaling, and cellular processes and metabolism can drive autoimmunity, immunodeficiency and/or allergic inflammation. Identification of these variants have improved our understanding of the role that many of these proteins play in skewing towards Th2 related allergic inflammation...
May 16, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38761994/inflammatory-memory-in-psoriasis-from-remission-to-recurrence
#28
REVIEW
Luc Francis, Francesca Capon, Catherine H Smith, Muzlifah Haniffa, Satveer K Mahil
The routine use of targeted systemic immunomodulatory therapies has transformed outcomes for people with severe psoriasis, with skin clearance (clinical remission) rates up to 60% at one year of biologic treatment. However, psoriasis may recur following drug withdrawal, and so patients tend to remain on costly treatment indefinitely. Here, we review research into the 'inflammatory memory' in resolved psoriasis skin and the potential mechanisms leading to psoriasis recurrence following drug withdrawal. Research has implicated immune cells such as tissue-resident memory T cells, Langerhans cells and dermal dendritic cells, and there is growing interest in keratinocytes and fibroblasts...
May 16, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38759801/mechanisms-underlying-skin-inflammation-of-dock8-deficiency
#29
EDITORIAL
Mathieu Fusaro, Loïc Dupré
No abstract text is available yet for this article.
May 15, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38754637/dupilumab-for-chronic-spontaneous-urticaria-marvelous-or-meek
#30
EDITORIAL
Sameer K Mathur, Daniel L Rosenberg, Ravi K Viswanathan, Madison Wis
No abstract text is available yet for this article.
May 14, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38750825/clinical-and-molecular-correlates-of-the-index-of-severity-for-eosinophilic-esophagitis
#31
JOURNAL ARTICLE
Hiroki Sato, Evan S Dellon, Seema S Aceves, Nicoleta C Arva, Mirna Chehade, Margaret H Collins, Carla M Davis, Gary W Falk, Glenn T Furuta, Nirmala P Gonsalves, Sandeep K Gupta, Ikuo Hirano, Girish Hiremath, David A Katzka, Paneez Khoury, John Leung, Paul Menard-Katcher, Robbie Pesek, Kathryn A Peterson, Maria A Pletneva, Jonathan M Spergel, Joshua B Wechsler, Guang-Yu Yang, Marc E Rothenberg, Tetsuo Shoda
BACKGROUND: The Index of Severity for Eosinophilic Esophagitis (I-SEE) is a new expert-defined clinical tool that classifies disease severity of eosinophilic esophagitis (EoE). OBJECTIVE: We aimed to determine whether I-SEE is associated with patient characteristics and/or molecular features of EoE. METHODS: We analyzed a prospective cohort of patients with EoE from the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)...
May 13, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38750824/loss-of-the-trpm4-channel-in-humans-causes-immune-dysregulation-with-defective-monocyte-migration
#32
JOURNAL ARTICLE
Fang Yu, Satanay Hubrack, Christophe M Raynaud, Asha Elmi, Rafah Mackeh, Nourhen Agrebi, Gaurav Thareja, Abdelaziz Belkadi, Hesham Al Saloos, Ayeda Abdulsalam Ahmed, Saleema C Purayil, Yasmin A Mohamoud, Karsten Suhre, Charbel Abi Khalil, Frank Schmidt, Bernice Lo, Amel Hassan, Khaled Machaca
BACKGROUND: Transient receptor potential melastatin subfamily member 4 (TRPM4) is a broadly expressed, calcium-activated, monovalent cation channel that regulates immune cell function in mice and cell lines. Clinically however, partial loss or gain of function mutations in TRPM4 lead to arrythmia and heart disease, with no documentation of immunological disorders. OBJECTIVE: To characterize the functional cellular mechanisms underlying the immune dysregulation phenotype in a proband with a mutated trpm4 gene...
May 13, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38734388/utility-of-t-h-2-cell-biomarkers-to-predict-outcomes-and-treatment-response-in-children-with-asthma
#33
EDITORIAL
W Gerald Teague, Cameron Griffiths
No abstract text is available yet for this article.
May 9, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38734387/impulse-oscillometry-gathering-speed-in-the-assessment-of-preschool-lung-function
#34
EDITORIAL
Theresa W Guilbert, Karen M McDowell
No abstract text is available yet for this article.
May 9, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38734386/staphylococcus-aureus-specific-skin-resident-memory-t-cells-protect-against-bacteria-colonization-but-exacerbate-atopic-dermatitis-like-flares-in-mice
#35
JOURNAL ARTICLE
Camille Braun, Cédric Badiou, Aurélie Guironnet-Paquet, Masashi Iwata, Vanina Lenief, Amandine Mosnier, Charlotte Beauclair, Emilie Renucci, Pauline Bouschon, Roxane Cuzin, Yoann Briend, Vijaykumar Patra, Sabine Patot, Tiffany C Scharschmidt, Willem van Wamel, Nicole Lemmens, Saeko Nakajima, François Vandenesh, Jean-François Nicolas, Gérard Lina, Audrey Nosbaum, Marc Vocanson
BACKGROUND: The contribution of Staphylococcus aureus (S. aureus) to the exacerbation of atopic dermatitis (AD) is widely documented, but its role as a primary trigger of AD skin symptoms remains poorly explored. OBJECTIVE: To reappraise the main bacterial factors and underlying immune mechanisms by which S. aureus triggers AD-like inflammation. METHODS: We capitalized on a pre-clinical model, in which different clinical isolates were applied in the absence of any prior experimental skin injury...
May 9, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38734385/nasal-solitary-chemosensory-cells-govern-daily-rhythm-in-mouse-model-of-allergic-rhinitis
#36
JOURNAL ARTICLE
Haiman Xu, Lianxia Guo, Tingying Hao, Xiaocao Guo, Meiping Huang, Haobin Cen, Min Chen, Jiaxian Weng, Meixia Huang, Zicong Wu, Zifei Qin, Jing Yang, Baojian Wu
BACKGROUND: While the daily rhythm of allergic rhinitis (AR) has long been recognized, the molecular mechanism underlying this phenomenon remains enigmatic. OBJECTIVE: We aim to investigate the role of circadian clock in AR development and to clarify the mechanism by which the daily rhythm of AR is generated. METHODS: AR was induced in mice using the ovalbumin method. Toluidine blue staining, LC-MS/MS analysis, qPCR, and immunoblotting were performed with AR and control mice...
May 9, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38729581/trajectories-and-phenotypes-of-rhinitis-and-wheeze
#37
EDITORIAL
Markus Ege
No abstract text is available yet for this article.
May 8, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38718950/a-pediatric-randomized-controlled-trial-of-german-cockroach-subcutaneous-immunotherapy
#38
JOURNAL ARTICLE
Edward Zoratti, Robert Wood, Anna Pomés, Ricardo Da Silva Antunes, Matthew C Altman, Basilin Benson, Lisa M Wheatley, Kate Cho, Agustin Calatroni, Frederic F Little, J Pongracic, Melanie Makhija, Gurjit K Khurana Hershey, Michael G Sherenian, Katherine Rivera-Spoljaric, Jeffrey R Stokes, Michelle A Gill, Rebecca S Gruchalla, Jeffrey Chambliss, Andrew H Liu, Meyer Kattan, Paula J Busse, Leonard B Bacharier, William Sheehan, Haejin Kim, Jill Glesner, Peter J Gergen, Alkis Togias, Jessica L Baucom, Cynthia M Visness, Alessandro Sette, William W Busse, Daniel J Jackson
BACKGROUND: Cockroach allergy contributes to morbidity among urban children with asthma. Few trials address the effect of subcutaneous immunotherapy (SCIT) with cockroach allergen among these at-risk children. OBJECTIVES: We sought to determine whether nasal allergen challenge (NAC) responses to cockroach allergen would improve following 1 year of SCIT. METHODS: Urban children with asthma, who were cockroach-sensitized and reactive on NAC, participated in a year-long randomized double-blind placebo-controlled SCIT trial using German cockroach extract...
May 6, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38718949/pegylated-liposomes-for-diagnosis-of-polyethylene-glycol-allergy
#39
JOURNAL ARTICLE
Griffith B Perkins, Matthew J Tunbridge, Plinio R Hurtado, James Zuiani, Shweta Mhatre, Kwok Ho Yip, Thanh-Thao Adriana Le, Carlo Yuson, Frank Kette, Pravin Hissaria
BACKGROUND: Polyethylene glycol (PEG) is a non-protein polymer that is present in its native (unbound) form as an excipient in a range of products, and is increasingly being utilised clinically in the form of PEGylated liposomal medications and vaccines. PEG is the cause of anaphylaxis in a small percentage of drug reactions, however diagnosis of PEG allergy is complicated by the variable and poor diagnostic performance of current skin testing protocols. OBJECTIVE: We assessed the diagnostic performance of PEGylated lipid medications as an alternative to currently described tests that use medications containing PEG excipients...
May 6, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38718948/impaired-hdl-function-and-endothelial-barrier-stability-in-severe-anaphylaxis
#40
JOURNAL ARTICLE
Sergio Fernandez-Bravo, Marina Canyelles, Ariadna Martín-Blázquez, Carla Borràs, Emilio Nuñez-Borque, Lucia Palacio-García, Pablo Rodríguez Del Rio, Diana Betancor, Alicia Gómez-López, Marina Sabaté Brescó, José Julio Laguna, Nerea Méndez-Barbero, Noemi Rotllan, Joan Carles Escolà-Gil, Vanesa Esteban
BACKGROUND: Growing evidence demonstrates the importance of high- and low-density lipoprotein cholesterol in certain immune and allergy-mediated diseases. OBJECTIVE: This study aimed to evaluate levels of high- and low-density lipoprotein cholesterol and apolipoproteins (Apo) A1 and B in serum from a cohort of patients presenting with hypersensitivity reactions. We further assessed the function of high-density lipoprotein particles as well as their involvement in the molecular mechanisms of anaphylaxis...
May 6, 2024: Journal of Allergy and Clinical Immunology
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