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JOURNAL ARTICLE
Cholinergic Sensing of Allergen Exposure by Airway Epithelium Promotes Type 2 Immunity in the Lungs.
Ryusuke Hayashi, Yotesawee Srisomboon, Koji Iijima, Peter J Maniak, Rinna Tei, Takao Kobayashi, Mayumi Matsunaga, Huijun Luo, Mia Y Masuda, Scott M O'Grady, Hirohito Kita
BACKGROUND: Non-neuronal cells, including epithelial cells, can produce acetylcholine (ACh). Muscarinic ACh receptor antagonists are used clinically to treat asthma and other medical conditions; however, knowledge regarding the roles of ACh in type 2 immunity is limited. OBJECTIVE: To investigate the roles of epithelial ACh in allergic immune responses. METHODS: Human bronchial epithelial (HBE) cells were cultured with allergen extracts, and their ACh production and interleukin (IL)-33 secretion were studied in vitro...
November 22, 2023: Journal of Allergy and Clinical Immunology
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JOURNAL ARTICLE
Suha Lim, Roza Khalmuratova, Yun Young Lee, Yi Sook Kim, Mingyu Lee, Na Kyeong Lee, Se-Na Kim, Young Bin Choy, Chun Gwon Park, Dae Woo Kim, Hyun-Woo Shin
BACKGROUND: Neutrophil extracellular traps (NETs) are observed in chronic rhinosinusitis (CRS), although their role remains unclear. OBJECTIVE: This study aimed to investigate the influence of NETs on the CRS epithelium. METHODS: Forty-five sinonasal biopsy specimens were immunofluorescence-stained to identify NETs and p63+ basal stem cells. We treated human nasal epithelial cells with NETs and studied them with immunofluorescence staining, western blotting, and quantitative real-time polymerase chain reaction...
November 22, 2023: Journal of Allergy and Clinical Immunology
#3
JOURNAL ARTICLE
Leah Ishmael, Andrea Apter, Paula J Busse, Rafael Calderon-Candelario, Jennifer K Carroll, Thomas Casale, Juan C Celedón, Rubin Cohen, Tamera Coyne-Beasley, Jing Cui, Brianna Ericson, Paulina Hernandez, David C Kaelber, Nancy Maher, Conner Merriman, Giselle Mosnaim, Sylvette Nazario, Wanda Phipatanakul, Victor Pinto-Plata, Isaretta Riley, Kartik Shenoy, Juan Wisnivesky, Barbara Yawn, Elliot Israel, Juan Carlos Cardet
BACKGROUND: Black adults are disproportionately affected by asthma but are often considered a homogenous group in research studies despite cultural and ancestral differences. OBJECTIVE: We sought to determine if asthma morbidity differs across adults in Black ethnic subgroups. METHODS: Adults with moderate-severe asthma were recruited across the continental US and Puerto Rico for the PREPARE trial. Using self-identifications, we categorized "Multi-ethnic Blacks" (ME/B; n=226) as "Black Latinx" (n=146) or "Caribbean, Continental African, or Other Blacks" (CAO/B; n=80)...
November 22, 2023: Journal of Allergy and Clinical Immunology
#4
JOURNAL ARTICLE
Elaine Fuertes, Debbie Jarvis, Holly Lam, Bethan Davies, Daniela Fecht, Joana Candeias, Carsten B Schmidt-Weber, Abdel Douiri, Anna Slovick, Enrico Scala, Thomas El Smith, Mohamed Shamji, Jeroen Tm Buters, Lorenzo Cecchi, Stephen J Till
BACKGROUND: Studies have linked daily pollen counts to respiratory allergic health outcomes but few have considered allergen levels. OBJECTIVE: This study assessed associations of grass pollen counts and allergen levels (Phl p 5) with 1) respiratory allergic health symptoms in a panel of 93 adults with moderate-severe allergic rhinitis and 2) daily asthma hospital admissions in London, UK. METHODS: Daily symptom and medication scores were collected from adult participants in an allergy clinical trial...
November 21, 2023: Journal of Allergy and Clinical Immunology
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REVIEW
Cosby A Stone, Benjamin W Spiller, Scott A Smith
The use of human antibodies as biologic therapeutics has revolutionized patient care throughout fields of medicine. As our understanding of the many roles antibodies play within our natural immune responses continues to advance, so will the number of therapeutic indications for which a monoclonal antibody will be developed. The great breadth of function, long half-life, and modular structure allow for nearly limitless therapeutic possibility. Human antibodies can be rationally engineered to enhance their desired immune functions and eliminate those that may result in unwanted effects...
November 21, 2023: Journal of Allergy and Clinical Immunology
#6
REVIEW
Laure Migayron, Ribal Merhi, Julien Seneschal, Katia Boniface
Tissue-resident memory T (TRM ) cells serve as a first line of defense in peripheral tissues to protect the organism against foreign pathogens. However, autoreactive TRM cells are increasingly implicated in autoimmunity, as evidenced in chronic autoimmune and inflammatory skin conditions. This highlights the need to characterize their phenotype and understand their role in order to target them specifically without affecting local immunity. To date, the investigation of TRM cells in human skin diseases has mainly focused on lesional tissues of patients...
November 21, 2023: Journal of Allergy and Clinical Immunology
#7
EDITORIAL
Geoffroy Laumet
No abstract text is available yet for this article.
November 21, 2023: Journal of Allergy and Clinical Immunology
#8
JOURNAL ARTICLE
Emily Croce, Layla Parast, Darlene Bhavnani, Elizabeth C Matsui
BACKGROUND: Racial disparities in atopic disease (atopic dermatitis (AD), asthma, and allergies) prevalence are well documented. Despite strong associations between race and socioeconomic deprivation in the United States (US), and socioeconomic status (SES) and atopic diseases, the extent to which socioeconomic status (SES) explains these disparities is not fully understood. METHODS: We utilized the National Health Interview Survey (2011-2018), to investigate AD, asthma, and respiratory allergy prevalence in Black and White children and the extent to which measures of SES explain any identified disparities...
November 21, 2023: Journal of Allergy and Clinical Immunology
#9
JOURNAL ARTICLE
Julie Nyholm Kyvsgaard, Nicklas Brustad, Laura Marie Hesselberg, Nilo Vahman, Jonathan Thorsen, Ann-Marie Malby Schoos, Klaus Bønnelykke, Jakob Stokholm, Bo Lund Chawes
BACKGROUND: Risk factors of asthma-like symptoms in childhood may act through an increased infection burden as infections often trigger these symptoms. ObjectiveTo investigate whether the effect of established risk factors of asthma-like episodes in early childhood is mediated through burden and subtypes of common infections. METHODS: The study included 662 children from the COPSAC2010 mother-child cohort, where infections were registered prospectively in daily diaries at age 0-3 years...
November 21, 2023: Journal of Allergy and Clinical Immunology
#10
EDITORIAL
Michael B Jordan
No abstract text is available yet for this article.
November 20, 2023: Journal of Allergy and Clinical Immunology
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EDITORIAL
Aikaterini Anagnostou, Julia E M Upton, R Sharon Chinthrajah
No abstract text is available yet for this article.
November 20, 2023: Journal of Allergy and Clinical Immunology
#12
EDITORIAL
Quanbo Wang, Charles R Mackay
We show that the gut bacterial metabolites, short chain fatty acids (SCFAs), are present at exceptionally high concentrations in the portal venous circulation, particularly small blood vessels that emanate from colonic mucosa. Likely, many other metabolites will be present at high concentrations. Herein we propose a model for immune conditioning, whereby metabolites such as butyrate affect immune cells as they pass through the portal venous system. Deficiency of SCFA would lead to pro-inflammatory immune cell skewing through insufficient G-protein coupled receptor (GPCR) signalling, or lack of histone deacetylase (HDAC) inhibition...
November 20, 2023: Journal of Allergy and Clinical Immunology
#13
LETTER
Syed-Rehan A Hussain, Mitchell H Grayson
No abstract text is available yet for this article.
November 20, 2023: Journal of Allergy and Clinical Immunology
#14
LETTER
#15
LETTER
Krishan D Chhiba, Fei Li Kuang, Sergejs Berdnikovs, Atsushi Kato, Bruce S Bochner
No abstract text is available yet for this article.
November 20, 2023: Journal of Allergy and Clinical Immunology
#16
EDITORIAL
Gulbu Uzel, Baerbel Keller, Klaus Warnatz
No abstract text is available yet for this article.
November 18, 2023: Journal of Allergy and Clinical Immunology
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JOURNAL ARTICLE
Anna M Trier, Aaron Ver Heul, Avery Fredman, Victoria Le, Zhen Wang, Kelsey Auyeung, James Meixiong, Paola Lovato, Michael J Holtzman, Fang Wang, Xinzhong Dong, Andrew L Ji, Brian S Kim
BACKGROUND: Itch is a common symptom that can greatly diminish quality of life. Histamine is a potent endogenous pruritogen, and while antihistamines are often the first-line treatment for itch, in conditions like chronic spontaneous urticaria (CSU), many patients remain symptomatic on maximal doses. Mechanisms that drive resistance to antihistamines are poorly defined. OBJECTIVES: Signaling of the alarmin cytokine IL-33 in sensory neurons is postulated to drive chronic itch by inducing neuronal sensitization to pruritogens...
November 18, 2023: Journal of Allergy and Clinical Immunology
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JOURNAL ARTICLE
Anne Rensing-Ehl, Myriam Ricarda Lorenz, Marita Führer, Wolfgang Willenbacher, Ella Willenbacher, Sieghart Sopper, Mario Abinun, Maria Elena Maccari, Christoph König, Pauline Haegele, Sebastian Fuchs, Carla Castro, Patrick Kury, Olivier Pelle, Christian Klemann, Maximilian Heeg, Julian Thalhammer, Oliver Wegehaupt, Marco Fischer, Sigune Goldacker, Björn Schulte, Saskia Biskup, Philippe Chatelain, Volker Schuster, Klaus Warnatz, Bodo Grimbacher, Andrea Meinhardt, Dirk Holzinger, Prasad Thomas Oommen, Tanja Hinze, Holger Hebart, Karlheinz Seeger, Kai Lehmberg, Timothy Ronan Leahy, Alexander Claviez, Simon Vieth, Freimut H Schilling, Ilka Fuchs, Miriam Groß, Frederic Rieux-Laucat, Aude Magerus, Carsten Speckmann, Klaus Schwarz, Stephan Ehl
BACKGROUND: Elevated TCRαβ+ CD4- CD8- double-negative T-cells (DNT) and serum biomarkers help identifying FAS mutant patients with autoimmune lymphoproliferative syndrome (ALPS). However, in some patients with clinical features and biomarkers consistent with ALPS, germline or somatic FAS mutations cannot be identified upon standard exon sequencing (ALPS-undetermined: ALPS-U). OBJECTIVE: We aimed to explore whether complex genetic alterations in the FAS gene escaping standard sequencing or mutations in other FAS pathway-related genes could explain these cases...
November 16, 2023: Journal of Allergy and Clinical Immunology
#19
REVIEW
Aude Magerus, Anne Rensing-Ehl, V Koneti Rao, David Teachey, Frederic Rieux-Laucat, Stephan Ehl
Chronic nonmalignant lymphoproliferation and autoimmune cytopenia are relevant manifestations of immunohematological diseases of childhood. Their diagnostic classification is challenging, but important for therapy. Autoimmune-lymphoproliferative syndrome (ALPS) is a genetically defined inborn error of immunity combining these manifestations, but can only explain a small proportion of cases. Diagnostic categories such as "ALPS-like" disease, common variable immunodeficiency (CVID), or Evans syndrome have therefore been used...
November 15, 2023: Journal of Allergy and Clinical Immunology
#20
JOURNAL ARTICLE
Mirelle T A Kleuskens, Maria L Haasnoot, Johan Garssen, Albert J Bredenoord, Betty C A M van Esch, Frank A Redegeld
BACKGROUND: Exposure of the esophageal mucosa to food allergens can cause acute mucosal responses in patients with eosinophilic esophagitis (EoE), but the underlying local immune mechanisms driving these acute responses are not well understood. OBJECTIVE: To gain insight into the early transcriptomic changes that occur during an acute mucosal response to food allergens in EoE. METHODS: Bulk RNA-sequencing was performed on esophageal biopsies from adult EoE patients (n = 5) collected before and 20 minutes after intramucosal injection of various food extracts in the esophagus...
November 14, 2023: Journal of Allergy and Clinical Immunology
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