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Journal of Allergy and Clinical Immunology

Kanokvalai Kulthanan, Saowalak Hunnangkul, Papapit Tuchinda, Leena Chularojanamontri, Puncharas Weerasubpong, Chanika Subchookul, Marcus Maurer
BACKGROUND: Several treatment options for cold urticaria (ColdU) have been studied and reported, but systematic reviews and meta-analyses are limited. OBJECTIVES: To meta-analyze and review the efficacy and safety of ColdU treatments. METHODS: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. Suitable reports were identified by searching PubMed, Scopus, and Web of Science. Our systematic review included 16 studies, 9 of which met the eligibility criteria for the meta-analysis...
February 15, 2019: Journal of Allergy and Clinical Immunology
Katherine C Konvinse, Jason A Trubiano, Rebecca Pavlos, Ian James, Christian M Shaffer, Cosmin A Bejan, Ryan J Schutte, David A Ostrov, Mark A Pilkinton, Misha Rosenbach, Jeffrey P Zwerner, Kristina B Williams, Jack Bourke, Patricia Martinez, Francois Rwandamuriye, Abha Chopra, Mark Watson, Alec J Redwood, Katie D White, Simon A Mallal, Elizabeth J Phillips
BACKGROUND: Vancomycin is a prevalent cause of the severe hypersensitivity syndrome drug reaction with eosinophilia and systemic symptoms (DRESS) which leads to significant morbidity and mortality and commonly occurs in the setting of combination antibiotic therapy which impacts future treatment choices. Variations in human leukocyte antigen (HLA) class I in particular have been associated with serious T-cell mediated adverse drug reactions which has led to preventive screening strategies for some drugs...
February 15, 2019: Journal of Allergy and Clinical Immunology
Carole Le Coz, Neil Romberg
No abstract text is available yet for this article.
February 14, 2019: Journal of Allergy and Clinical Immunology
Giampaolo Trivellin, Constantine A Stratakis
No abstract text is available yet for this article.
February 14, 2019: Journal of Allergy and Clinical Immunology
Hella Luksch, W Alexander Stinson, Derek J Platt, Wei Qian, Gowri Kalugotla, Cathrine A Miner, Brock G Bennion, Alexander Gerbaulet, Angela Rösen-Wolff, Jonathan J Miner
BACKGROUND: Monogenic interferonopathies are thought to be mediated by type I interferon (IFN). For example, a gain-of-function mutation in STING (STING N153S) up-regulates type I IFN-stimulated genes (ISGs) and causes perivascular inflammatory lung disease in mice. The equivalent mutation in humans also causes lung disease, which is thought to require signaling through the cGAS-STING pathway and subsequent activation of IFN regulatory factors (IRF) 3/7, type I IFN, and ISGs. OBJECTIVE: We set out to define the roles of cGAS, IRF3, IRF7, the type I IFN receptor (IFNAR1), T cells, and B cells in spontaneous lung disease in STING N153S mice...
February 14, 2019: Journal of Allergy and Clinical Immunology
Michael Huber, Andrew C B Cato, George K Ainooson, Marc Freichel, Volodymyr Tsvilovskyy, Rolf Jessberger, Eva Riedlinger, Christian P Sommerhoff, Stephan C Bischoff
Mast cells, best known for their detrimental role in allergic diseases, act in a diverse array of physiological and pathological functions, made possible by the plurality of mast cell types. Their various developmental avenues and their distinct sensitivity to (micro-) environmental conditions convey extensive heterogeneity, resulting in diverse functions. We briefly summarize this heterogeneity, elaborate on molecular determinants that allow mast cells to communicate with their environment to fulfill their tasks, discuss their protease repertoire stored in secretory lysosomes, and consider different aspects of mast cell signaling...
February 14, 2019: Journal of Allergy and Clinical Immunology
Stefano Volpi, Maria Pia Cicalese, Paul Tuijnenburg, Anton T J Tool, Eloy Cuadrado, Hamid Ahanchian, Raed Alzyoud, Zeynep Coban Akdemir, Federica Barzaghi, Alexander Blank, Bertrand Boisson, Cristina Bottino, Roberta Caorsi, Jean-Laurent Casanova, Sabrina Chiesa, Ivan Kingyue Chinn, Gregor Dückers, Anselm Enders, Hans Christian Erichsen, Lisa R Forbes, Tomasz Gambin, Marco Gattorno, Ehsan Ghayoor Karimiani, Silvia Giliani, Michael S Gold, Marwan Abu-Halaweh, Immacolata Brigida, Eva-Maria Jacobsen, Machiel H Jansen, Jovanka R King, Ronald M Laxer, James R Lupski, Emily Mace, Stefania Marcenaro, Reza Maroofian, Alexander B Meijer, Tim Niehues, Luigi D Notarangelo, Jordan Orange, Ulrich Pannicke, Chris Pearson, Paolo Picco, Patrick J Quinn, Ansgar Schulz, Filiz Seeborg, Asbjørg Stray-Pedersen, Hasan Tawamie, Ester M M van Leeuwen, Alessandro Aiuti, Rae Yeung, Klaus Schwarz, Taco W Kuijpers
We report the natural history, clinical manifestations, genetics, and immunohematological findings in 14 patients from 11 families with ARPC1B deficiency, delineating the spectrum of the disease that appears progressive and challenging to manage clinically.
February 13, 2019: Journal of Allergy and Clinical Immunology
Maryam Hussain, Germán Bonilla-Rosso, Cheong Kc Kwong Chung, Lukas Bäriswyl, Maria Pena Rodriguez, Brian S Kim, Philipp Engel, Mario Noti
BACKGROUND: Diet-induced obesity and food allergies rise in tandem, but a potential cause-and-effect relationship between these diseases of affluence remains to be tested. OBJECTIVE: To test the role of high dietary fat intake, diet-induced obesity and associated changes in gut microbial community structure on food allergy pathogenesis. METHODS: Mice were fed a high fat diet (HFD) for 12 weeks prior to food allergen sensitization on an atopic dermatitis-like skin lesion followed by intra-gastric allergen challenge to induce experimental food allergy...
February 12, 2019: Journal of Allergy and Clinical Immunology
Daniela Impellizzieri, Frederike Ridder, Miro E Raeber, Cecilie Egholm, Janine Woytschak, Antonios G A Kolios, Daniel F Legler, Onur Boyman
BACKGROUND: Type 2 immunity serves to resist parasitic helminths, venoms and toxins, but the role and regulation of neutrophils during type 2 immune responses is controversial. Helminth models suggested a contribution of neutrophils to type 2 immunity, whereas neutrophils are associated with increased disease severity during type 2 inflammatory disorders such as asthma. OBJECTIVE: To evaluate the impact of the prototypic type 2 cytokines interleukin-4 (IL-4) and IL-13 on human neutrophils...
February 12, 2019: Journal of Allergy and Clinical Immunology
Tanzeela Hanif, Kishor Dhaygude, Matti Kankainen, Jutta Renkonen, Pirkko Mattila, Teija Ojala, Sakari Joenvaara, Mika Mäkelä, Anna Pelkonen, Paula Kauppi, Tari Haahtela, Risto Renkonen, Sanna Toppila-Salmi
Nasal epithelial transcriptome is altered by the season. Birch pollen allergen immunotherapy recovers microbial community diversity and alters expression of allergy related genes.
February 12, 2019: Journal of Allergy and Clinical Immunology
Mohamed H Shamji, Irene Thomsen, Janice Layhadi, Jasper Kappen, Gabriële Holtappels, Umit Sahiner, Amy Switzer, Stephen R Durham, Oliver Pabst, Claus Bachert
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by local production of polyclonal IgE-idiotypes. Whilst tissue IgE concentrations can be in the range of several thousand kU/L, the regulatory mechanisms by which IgE-mediated inflammation is controlled in the nasal polyps is not well understood. OBJECTIVE: We sought to determine whether locally induced IgG antibodies in the nasal polyps can inhibit IgE-mediated pro-allergic response...
February 11, 2019: Journal of Allergy and Clinical Immunology
Ulrika Käck, Anna Asarnoj, Hans Grönlund, Magnus P Borres, Marianne van Hage, Gunnar Lilja, Jon R Konradsen
No abstract text is available yet for this article.
February 8, 2019: Journal of Allergy and Clinical Immunology
Gennaro Liccardi, Luigino Calzetta, Manlio Milanese, Giovanni Passalacqua, Paola Rogliani
No abstract text is available yet for this article.
February 8, 2019: Journal of Allergy and Clinical Immunology
Tania E Velez, Adam J Byrne, Joshua B Wechsler, Rebecca A Krier-Burris, Kathryn E Hulse, Paul J Bryce
A histamine metabolite, imidazole acetic acid (IAA), recapitulates key histamine-driven biology, including recruitment of eosinophils, induction of itch, and induction of anaphylaxis. IAA may perpetuate anaphylactic and other allergic responses after the initial release and metabolism of histamine.
February 7, 2019: Journal of Allergy and Clinical Immunology
Devyani Lal, Benjamin L Wright, Kelly P Shim, Matthew A Zarka, James J Lee, Yu-Hui Chang, Sergei I Ochkur, Rohit Divekar, Alfred D Doyle, Elizabeth A Jacobsen, Hirohito Kita, Matthew A Rank
Eosinophil peroxidase is a potential biomarker for eosinophilic chronic rhinosinusitis. Th2/Th1 polarization, as measured by GATA3 and T-bet, was not associated with eosinophilia or any clinical or histopathologic feature of chronic rhinosinusitis.
February 7, 2019: Journal of Allergy and Clinical Immunology
Julia Bier, Geetha Rao, Kathryn Payne, Henry Brigden, Elise French, Simon J Pelham, Anthony Lau, Helen Lenthall, Emily S J Edwards, Joanne M Smart, Theresa S Cole, Sharon Choo, Avni Y Joshi, Roshini S Abraham, Michael O'Sullivan, Kaan Boztug, Isabelle Meyts, Paul E Gray, Lucinda J Berglund, Peter Hsu, Melanie Wong, Steven M Holland, Luigi D Notarangelo, Gulbu Uzel, Cindy S Ma, Robert Brink, Stuart G Tangye, Elissa K Deenick
BACKGROUND: Gain of function (GOF) mutations in PIK3CD cause a primary immunodeficiency characterized by recurrent respiratory tract infections, susceptibility to herpes virus infections and impaired antibody responses. Previous work revealed defects in CD8+ T and B cells that contribute to this clinical phenotype but less is understood about the role of CD4+ T cells in disease pathogenesis. OBJECTIVE: To dissect the effects of increased phosphoinositide-3 kinase (PI3K) signaling on CD4+ T cell function...
February 6, 2019: Journal of Allergy and Clinical Immunology
Cheng Peng, Andres Cardenas, Sheryl L Rifas-Shiman, Marie-France Hivert, Diane R Gold, Thomas A Platts-Mills, Xihong Lin, Emily Oken, Lydiana Avila, Juan C Celedón, Scott T Weiss, Andrea A Baccarelli, Augusto A Litonjua, Dawn L DeMeo
BACKGROUND: Epigenetic clocks have been suggested to capture one feature of the complexity between aging and the epigenome. However, little is known about the epigenetic clock in childhood allergy and asthma. OBJECTIVE: To examine associations of DNA methylation age (DNAmAge) and epigenetic age acceleration with childhood allergy and asthma. METHODS: We calculated DNAmAge and age acceleration at birth, early and mid-childhood based on IlluminaHumanMethylation450BeadChip in Project Viva...
February 6, 2019: Journal of Allergy and Clinical Immunology
Emma Guttman-Yassky, Ana B Pavel, Lisa Zhou, Yeriel D Estrada, Ning Zhang, Hui Xu, Xiangyu Peng, Huei-Chi Wen, Panayiota Govas, Girish Gudi, C A Vinu, Hui Fang, Yacine Salhi, Jonathan Back, Venkateshwar Reddy, Robert Bissonnette, Catherine Maari, Fred Grossman, Gerhard Wolff
BACKGROUND: GBR 830 is a humanized, monoclonal antibody against OX40, a co-stimulatory receptor on activated T-cells. OX40 inhibition may have a therapeutic role in T-cell-mediated diseases, including atopic dermatitis (AD). OBJECTIVE: This exploratory phase 2a study investigated safety, efficacy, and tissue effects of GBR 830 in AD. METHODS: Moderate-to-severe AD subjects (affected body-surface area ≥10%, Eczema Area and Severity Index [EASI] ≥12, inadequate response to topical treatments) were randomized 3:1 to intravenous GBR 830 10 mg/kg or placebo on Day 1/baseline and Day 29...
February 6, 2019: Journal of Allergy and Clinical Immunology
Sanjana Mahapatra, William T Shearer, Charles G Minard, Emily Mace, Mary Paul, Jordan S Orange
BACKGROUND: Chronic human immunodeficiency virus (HIV) infection is known to trigger a population redistribution and alteration in the functional capacity of NK cells. Due to improved anti-retroviral treatments, there are rising numbers of adolescents and young adults worldwide that are living with HIV infection since birth. OBJECTIVE: We sought to determine how NK cell phenotypic and functional subsets are altered in treated pediatric patients. METHODS: NK cells were contrasted among 29 HIV-unexposed and uninfected controls (5-19 years), 23 HIV-exposed but uninfected patients (HEU) (3-19 years) and 25 HIV-infected patients (3-19 years) using multi-parametric flow cytometry...
February 5, 2019: Journal of Allergy and Clinical Immunology
Carla Winkler, Thomas Hochdörfer, Elisabeth Israelsson, Annemarie Hasselberg, Anders Cavallin, Kristofer Thörn, Daniel Muthas, Shervin Shojaee, Katrin Lueer, Meike Mueller, Jenny Mjösberg, Outi Vaarala, Jens Hohlfeld, Katerina Pardali
BACKGROUND: Group 2 innate lymphoid cells (ILC2) are effective producers of IL-5 and IL-13 during allergic inflammation and bridge the innate and adaptive immune response. ILC2 are increased in asthmatics compared to healthy controls. So far human data describing their phenotype during acute allergic inflammation in the lung is incomplete. OBJECTIVES: This study aims to characterize and compare blood- and lung-derived ILC2 before and after segmental allergen challenge in mild to moderate asthmatic individuals with high blood eosinophil levels (≥300/μl)...
February 4, 2019: Journal of Allergy and Clinical Immunology
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