Joost Brandsma, James P R Schofield, Xian Yang, Fabio Strazzeri, Clair Barber, Victoria M Goss, Grielof Koster, Per S Bakke, Massimo Caruso, Pascal Chanez, Sven-Erik Dahlén, Stephen J Fowler, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandström, Dominick E Shaw, Kian Fan Chung, Florian Singer, Louise J Fleming, Ian M Adcock, Ioannis Pandis, Aruna T Bansal, Julie Corfield, Ana R Sousa, Peter J Sterk, Rubén J Sánchez-García, Paul J Skipp, Anthony D Postle, Ratko Djukanović
BACKGROUND: Asthma is a chronic respiratory disease with significant heterogeneity in its clinical presentation and pathobiology. There is need for improved understanding of respiratory lipid metabolism in asthma patients and its relation to observable clinical features. OBJECTIVE: To perform a comprehensive, prospective, cross-sectional analysis of the lipid composition of induced sputum supernatant obtained from asthma patients with a range of disease severities, as well as healthy controls...
March 12, 2023: Journal of Allergy and Clinical Immunology