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Investigative Radiology

Jing Hao, Philippe Bourrinet, Pierre Desché
OBJECTIVES: The aim of this study was to evaluate the pharmacokinetics, safety profile, and pharmacodynamics of gadopiclenol, a new high relaxivity macrocyclic gadolinium-based contrast agent, in healthy subjects and patients with brain lesions. MATERIALS AND METHODS: This was a single ascending dose phase I/IIa study. Phase I was double-blind, randomized, placebo-controlled and included 54 healthy subjects. In each dose group (0.025, 0.05, 0.075, 0.1, 0.2, and 0...
March 12, 2019: Investigative Radiology
Nicole Berger, Magda Marcon, Natalia Saltybaeva, Willi A Kalender, Hatem Alkadhi, Thomas Frauenfelder, Andreas Boss
OBJECTIVES: The purpose of this work is to present the data obtained from the first clinical in vivo application of a new dedicated spiral breast computed tomography (B-CT) equipped with a photon-counting detector. MATERIALS AND METHODS: The institutional review board approved this retrospective study. Twelve women referred for breast cancer screening were included and underwent bilateral spiral B-CT acquired in prone position. Additional sonography was performed in case of dense breast tissue or any B-CT findings...
March 2, 2019: Investigative Radiology
Mário João Fartaria, Pascal Sati, Alexandra Todea, Ernst-Wilhelm Radue, Reza Rahmanzadeh, Kieran OʼBrien, Daniel S Reich, Meritxell Bach Cuadra, Tobias Kober, Cristina Granziera
OBJECTIVES: The aim of this study was to develop a new automated segmentation method of white matter (WM) and cortical multiple sclerosis (MS) lesions visible on magnetization-prepared 2 inversion-contrast rapid gradient echo (MP2RAGE) images acquired at 7 T MRI. MATERIALS AND METHODS: The proposed prototype (MSLAST [Multiple Sclerosis Lesion Analysis at Seven Tesla]) takes as input a single image contrast derived from the 7T MP2RAGE prototype sequence and is based on partial volume estimation and topological constraints...
March 2, 2019: Investigative Radiology
Viktor Imre Óriás, Marcell Gyánó, István Góg, Dávid Szöllősi, Dániel Sándor Veres, Zsuzsa Nagy, Csaba Csobay-Novák, Oláh Zoltán, János P Kiss, Szabolcs Osváth, Krisztián Szigeti, Ruzsa Zoltán, Péter Sótonyi
OBJECTIVES: Our aim was to investigate the feasibility of digital variance angiography (DVA) in lower extremity CO2 angiography and to compare the quantitative and qualitative performance of the new image processing technique with that of the current reference standard digital subtraction angiography (DSA). MATERIALS AND METHODS: This prospective study enrolled 24 patients (mean age ± SD, 65.5 ± 9.2 years; 14 males, 65.1 ± 7.5 years; 10 females, 66.1 ± 11.6 years) undergoing lower-limb CO2 angiography between December 2017 and April 2018 at 2 clinical centers: The Heart and Vascular Center (HVC) of Semmelweis University, Budapest (7 patients), and the Bács-Kiskun County Hospital (BKCH) in Kecskemét (17 patients)...
February 28, 2019: Investigative Radiology
Marie-Luise Kromrey, Nele Friedrich, Ralf-Thorsten Hoffmann, Robin Bülow, Henry Völzke, Frank U Weiss, Markus M Lerch, Utaroh Motosugi, Jens-Peter Kühn
OBJECTIVES: The aim of this study was to investigate if pancreatic steatosis measured by proton density fat fraction (PDFF) is associated with exocrine pancreatic function defined by fecal elastase concentrations. MATERIALS AND METHODS: A total of 1458 volunteers (777 women; age range, 21-88 years) underwent magnetic resonance imaging of the pancreas, and organ fat content was quantified by using confounder corrected PDFF. Exocrine pancreatic function was categorized by fecal elastase levels using defined cutoffs: greater than 200 μg/g normal function (n = 1319) and 200 μg/g or less impaired function (n = 139)...
February 26, 2019: Investigative Radiology
Ja Kyung Yoon, Myeong-Jin Kim, Sunyoung Lee
OBJECTIVES: The aim of this study was to investigate the utility of a combined compressed sensing and parallel imaging (C-SENSE) technique for single breath-hold, double arterial phase (AP) examinations in gadoxetate-enhanced magnetic resonance imaging (MRI) of the liver. MATERIALS AND METHODS: We retrospectively reviewed single breath-hold, double AP images obtained by using a C-SENSE technique for gadoxetate-enhanced dynamic liver MRI in a total of 127 patients (89 men and 38 women; mean age, 62...
February 1, 2019: Investigative Radiology
Barbara Dymerska, Pedro De Lima Cardoso, Beata Bachrata, Florian Fischmeister, Eva Matt, Roland Beisteiner, Siegfried Trattnig, Simon Daniel Robinson
OBJECTIVES: Gradients in the static magnetic field caused by tissues with differing magnetic susceptibilities lead to regional variations in the effective echo time, which modifies both image signal and BOLD sensitivity. Local echo time changes are not considered in the most commonly used metric for BOLD sensitivity, temporal signal-to-noise ratio (tSNR), but may be significant, particularly at ultrahigh field close to air cavities (such as the sinuses and ear canals) and near gross brain pathologies and postoperative sites...
February 1, 2019: Investigative Radiology
Paul Eichinger, Andreas Hock, Simon Schön, Christine Preibisch, Jan S Kirschke, Mark Mühlau, Claus Zimmer, Benedikt Wiestler
OBJECTIVE: The aim of this study was to assess the performance of double inversion recovery (DIR) sequences accelerated by compressed sensing (CS) in a clinical setting. MATERIALS AND METHODS: We included 106 patients with MS (62 female [58%]; mean age, 44.9 ± 11.0 years) in this prospective study. In addition to a full magnetic resonance imaging protocol including a conventional SENSE accelerated DIR, we acquired a CS DIR (time reduction, 51%). We generated subtraction maps between the two DIR sequences to visualize focal intensity differences...
January 31, 2019: Investigative Radiology
Tim Finkenstaedt, Reni Biswas, Nirusha A Abeydeera, Palanan Siriwanarangsun, Robert Healey, Sheronda Statum, Won C Bae, Christine B Chung
OBJECTIVES: In human menisci, we aimed to investigate whether calcium pyrophosphate crystal deposition (CPPD) affects biomechanical and quantitative MR properties, and their zonal distribution. MATERIALS AND METHODS: From 9 cadaveric knees, sectioned triangular meniscus pieces were harvested. Samples were classified into "normal" or "CPPD" groups based upon visual inspection. Micro computed tomography scan verified CPPD. Using magnetic resonance imaging, ultrashort echo time (UTE) T2* and spin echo (SE) T2, quantitative values in 3 zones (red, red-white, and white) were determined...
January 25, 2019: Investigative Radiology
Nivin N Nyström, Amanda M Hamilton, Wenyao Xia, Shirley Liu, Timothy J Scholl, John A Ronald
OBJECTIVES: Multimodality reporter gene imaging provides valuable, noninvasive information on the fate of engineered cell populations. To complement magnetic resonance imaging (MRI) measures of tumor volume and 2-dimensional reporter-based optical measures of cell viability, reporter-based MRI may offer 3-dimensional information on the distribution of viable cancer cells in deep tissues. MATERIALS AND METHODS: Here, we engineered human and murine triple-negative breast cancer cells with lentivirus encoding tdTomato and firefly luciferase for fluorescence imaging and bioluminescence imaging (BLI)...
January 21, 2019: Investigative Radiology
Keno K Bressem, Janis L Vahldiek, Christoph Erxleben, Franz Poch, Bernhard Hiebl, Kai Lehmann, Bernd Hamm, Stefan M Niehues
OBJECTIVES: The aim of this study was to investigate whether the accuracy of multislice contrast-enhanced computed tomography (MS-CECT) may be improved by performing additional subtraction CT. MATERIALS AND METHODS: Thirty-five microwave ablations were performed under CT guidance in 12 healthy and anesthetized pigs. Preablation and postablation MS-CECT scans were obtained in arterial and venous contrast phases. These scans were reconstructed and subtracted from each other...
January 15, 2019: Investigative Radiology
Mehmet U Dalmiş, Albert Gubern-Mérida, Suzan Vreemann, Peter Bult, Nico Karssemeijer, Ritse Mann, Jonas Teuwen
OBJECTIVES: We investigated artificial intelligence (AI)-based classification of benign and malignant breast lesions imaged with a multiparametric breast magnetic resonance imaging (MRI) protocol with ultrafast dynamic contrast-enhanced MRI, T2-weighted, and diffusion-weighted imaging with apparent diffusion coefficient mapping. MATERIALS AND METHODS: We analyzed 576 lesions imaged with MRI, including a consecutive set of biopsied malignant (368) and benign (149) lesions, and an additional set of 59 benign lesions proven by follow-up...
January 15, 2019: Investigative Radiology
Panagiotis Kapetas, Paola Clauser, Ramona Woitek, Georg J Wengert, Mathias Lazar, Katja Pinker, Thomas H Helbich, Pascal A T Baltzer
OBJECTIVES: The aim of this study was to evaluate breast multiparametric ultrasound (mpUS) and its potential to reduce unnecessary breast biopsies with 1, 2, or 3 additional quantitative parameters (Doppler, elastography, and contrast-enhanced ultrasound [CEUS]) to B-mode and investigate possible variations with different reader experience. MATERIALS AND METHODS: This prospective study included 124 women (age range, 18-82 years; mean, 52 years), each with 1 new breast lesion, scheduled for ultrasound-guided biopsy between October 2015 and September 2016...
January 10, 2019: Investigative Radiology
Pelin Aksit Ciris, Jr-Yuan George Chiou, Daniel I Glazer, Tzu-Cheng Chao, Clare M Tempany-Afdhal, Bruno Madore, Stephan E Maier
PURPOSE: The aim of this study was to improve the geometric fidelity and spatial resolution of multi-b diffusion-weighted magnetic resonance imaging of the prostate. MATERIALS AND METHODS: An accelerated segmented diffusion imaging sequence was developed and evaluated in 25 patients undergoing multiparametric magnetic resonance imaging examinations of the prostate. A reduced field of view was acquired using an endorectal coil. The number of sampled diffusion weightings, or b-factors, was increased to allow estimation of tissue perfusion based on the intravoxel incoherent motion (IVIM) model...
December 19, 2018: Investigative Radiology
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No abstract text is available yet for this article.
April 2019: Investigative Radiology
Bibi Martens, Babs M F Hendriks, Nienke G Eijsvoogel, Joachim E Wildberger, Casper Mihl
OBJECTIVES: The aim of the present study was to evaluate the attenuation and image quality (IQ) of a body weight-adapted contrast media (CM) protocol compared with a fixed injection protocol in computed tomography (CT) of the liver at 90 kV. MATERIALS AND METHODS: One hundred ninety-nine consecutive patients referred for abdominal CT imaging in portal venous phase were included. Group 1 (n = 100) received a fixed CM dose with a total iodine load (TIL) of 33 g I at a flow rate of 3...
March 2019: Investigative Radiology
David J Bartlett, Chi Wan Koo, Brian J Bartholmai, Kishore Rajendran, Jayse M Weaver, Ahmed F Halaweish, Shuai Leng, Cynthia H McCollough, Joel G Fletcher
OBJECTIVES: The aim of this study was to evaluate if a high-resolution photon-counting detector computed tomography (PCD-CT) system with a 1024×1024 matrix reconstruction can improve the visualization of fine structures in the lungs compared with conventional high-resolution CT (HRCT). MATERIALS AND METHODS: Twenty-two adult patients referred for clinical chest HRCT (mean CTDI vol, 13.58 mGy) underwent additional dose-matched PCD-CT (mean volume CT dose index, 13...
March 2019: Investigative Radiology
Marcus Raudner, Markus M Schreiner, Vladimir Juras, Michael Weber, David Stelzeneder, Claudia Kronnerwetter, Reinhard Windhager, Siegfried Trattnig
OBJECTIVES: The aim of this study was to assess the predictive value of T2 mapping at baseline with regard to the development of disk herniation and clinical outcome at a 5-year follow-up in patients with low back pain. MATERIALS AND METHODS: Twenty-five symptomatic patients (13 male; mean age, 44.0 years; range, 24-64 years at baseline) were examined at 3 T magnetic resonance imaging, with a 5-year follow-up. Region of interest analysis was performed on 125 lumbar intervertebral disks on 2 central sagittal T2 maps...
March 2019: Investigative Radiology
Nathalie Fretellier, Agnès Granottier, Marlène Rasschaert, Anne-Laure Grindel, Fannie Baudimont, Philippe Robert, Jean-Marc Idée, Claire Corot
OBJECTIVES: The main objective of the study was to assess the effect of age on target tissue total gadolinium (Gd) retention after repeated administration of gadodiamide (linear) or gadoterate (macrocyclic) Gd-based contrast agent (GBCA) in rats. The secondary objective was to assess the potential developmental and long-term consequences of GBCA administration during neonatal and juvenile periods. MATERIALS AND METHODS: A total of 20 equivalent human clinical doses (cumulated dose, 12 mmol Gd/kg) of either gadoterate or gadodiamide were administered concurrently by the intravenous route to healthy adult and juvenile rats...
February 2019: Investigative Radiology
Paola Clauser, Pascal A T Baltzer, Panagiotis Kapetas, Ramona Woitek, Michael Weber, Federica Leone, Maria Bernathova, Thomas H Helbich
OBJECTIVES: The aim of this study was to evaluate the detection rate and diagnostic performance of 2-dimensional synthetic mammography (SM) as an adjunct to wide-angle digital breast tomosynthesis (WA-DBT) compared with digital mammography (DM) alone or to DM in combination with WA-DBT. MATERIALS AND METHODS: There were 205 women with 179 lesions included in this retrospective reader study. Patients underwent bilateral, 2-view (2v) DM and WA-DBT between March and June 2015...
February 2019: Investigative Radiology
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