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Journals International Archives of Alle...

International Archives of Allergy and Immunology

https://read.qxmd.com/read/38035559/effectiveness-of-mepolizumab-in-patients-with-severe-eosinophilic-asthma-with-without-nasal-polyposis-a-real-life-study
#61
Francisco Javier Bravo-Gutiérrez, Juan Carlos Miralles-López, José Valverde-Molina, María Loreto Alemany Francés, Rubén Andújar-Espinosa, Manuel Castilla-Martínez, María Jesús Avilés-Inglés, Ana Mora-González, Manuel José Pajarón-Fernández, Sheila Cabrejos-Perotti, José Meseguer-Arce, Isabel Flores Martín, Virginia Pérez-Fernández
INTRODUCTION: Asthma is one of the most common chronic diseases and affects around 334 million people worldwide. The estimated prevalence of severe asthma is 3-10% of the asthmatic population. Mepolizumab has demonstrated efficacy in reducing exacerbations, oral corticosteroid use, and improving quality of life, asthma control, and lung function in patients with severe eosinophilic asthma (SEA). Our study aimed to check the response to mepolizumab in a series of severe asthma patients regarding exacerbations, oral corticosteroid use, asthma control, quality of life, and lung function and to compare the response between patients with and without nasal polyps...
November 30, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/38029733/comparing-protein-and-gene-expression-signature-between-nasal-polyps-and-nasal-fluids-in-chronic-rhinosinusitis
#62
JOURNAL ARTICLE
Yilin Hou, Changhui Chen, Zhengqi Li, Tong Lu, Lin Sun, Yi Wei, Jian Li, Weiping Wen
INTRODUCTION: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a serious inflammatory condition. Nasal fluids (NFs) present a noninvasive alternative to nasal biopsy for studying CRSwNP pathogenesis. We aimed to compare the protein and mRNA inflammation signature between nasal polyps (NPs) and NFs. METHOD: The performance of polyvinyl alcohol (PVA) sponges and NFs absorbable device (NFAD) for collecting NFs from 20 patients with CRSwNP was compared using the Luminex assay...
November 29, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37989115/applying-artificial-intelligence-to-identify-common-targets-for-treatment-of-asthma-eczema-and-food-allergy
#63
JOURNAL ARTICLE
Hei Man Liu, Andre Rayner, Andrew R Mendelsohn, Anastasia Shneyderman, Michelle Chen, Frank W Pun
INTRODUCTION: Allergic disorders are common diseases marked by the abnormal immune response toward foreign antigens that are not pathogens. Often patients with food allergy also suffer from asthma and eczema. Given the similarities of these diseases and a shortage of effective treatments, developing novel therapeutics against common targets of multiple allergies would offer an efficient and cost-effective treatment for patients. METHODS: We employed the artificial intelligence-driven target discovery platform, PandaOmics, to identify common targets for treating asthma, eczema, and food allergy...
November 21, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37989112/clinical-features-of-quail-egg-ingestion-in-patients-with-acquired-tolerance-to-hen-eggs-a-case-series-study
#64
JOURNAL ARTICLE
Kosei Yamashita, Yuki Okada, Aiko Honda, Chihiro Kunigami, Mayu Maeda, Toshinori Nakamura, Taro Kamiya, Takanori Imai
INTRODUCTION: Patients with hen's egg allergy are often instructed to avoid consuming other avian eggs, such as quail eggs. However, it is unclear whether patients with an acquired tolerance to hen eggs continue to avoid consuming quail eggs. This study aimed to evaluate the clinical features of quail egg ingestion. METHODS: This prospective case series included children aged ≥1 year with hen's egg allergy who were recruited between October 2019 and February 2021 in our hospital...
November 21, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37989104/foxp3-positive-cells-and-their-contacts-with-mast-cells-are-highly-increased-in-basal-cell-carcinoma
#65
Antti P Kaukinen, Rauno J Harvima, Ilkka T Harvima
INTRODUCTION: The cells of the immune system are thought to contribute to the development of skin cancers, such as basal cell carcinoma (BCC). One possible mechanism may be the interaction between mast cells and regulatory T cells (Tregs), resulting in immunosuppression. METHODS: Fresh-frozen biopsies from the lesional and nonlesional skin of 16 patients with BCC were processed for the enzymehistochemical staining of mast cell tryptase, immunohistochemical staining of FoxP3 (a marker of Tregs) as well as for the double-staining method to label tryptase+ cells and FoxP3+ cells on the same cryosection...
November 21, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37980884/gastroesophageal-reflux-disease-and-rhinosinusitis-a-bidirectional-mendelian-randomization-study
#66
JOURNAL ARTICLE
Teng-Yu Chen, Ming-Hui Lv, Ren-Jie Lai, Yu-Qi Hu, Zhong-Kang Ye, Qi-Liang Lv, Bao-Yi Chen, Jun-Tao Wu, Haiyu Hong, Shuo Li
INTRODUCTION: Comorbidities, such as gastroesophageal reflux disease (GERD), are common in patients with rhinosinusitis (RS). However, the link between RS and GERD has not been fully understood. This study aimed to investigate the causal relationship between GERD and acute (ARS) or chronic RS (CRS), providing references for the pathogenesis and management of RS. METHODS: The data were obtained from the Integrative Epidemiology Unit Open GWAS project and FinnGen...
November 17, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37963435/erratum
#67
(no author information available yet)
No abstract text is available yet for this article.
November 14, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37963429/blockade-of-hmgb1-reduces-inflammation-and-pruritus-in-atopic-dermatitis-by-inhibiting-skin-fibroblasts-activation
#68
JOURNAL ARTICLE
Lingxuan Zhou, Xiaohui Yuan, Yongyan Hu, Siyu Zhu, Junxiang Li, Chenyu Wang, Miao Jing, Lingling Liu, Zhe Xu, Zuotao Zhao, Jiahui Zhao
INTRODUCTION: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by relapsed eczema and serious pruritus. High-mobility group box 1 protein (HMGB1) is a nuclear-binding protein and serves as an alarmin to promote inflammatory responses. METHODS: In this study, we established an AD mouse model by topical use of MC903 on ears and then used a specific HMGB1-binding peptide cIY8 and a HMGB1 inhibitor of glycyrrhizin to investigate HMGB1 on fibroblast activation in the pathogenesis of AD-like symptoms...
November 14, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37952519/biomarkers-of-autologous-whole-blood-injection-efficacy-in-patients-with-chronic-spontaneous-urticaria-with-autoreactivity-a-preliminary-study
#69
Qiquan Chen, Jincheng Luo, Xianjie Yang, WenChieh Chen, Wenying Liu, Zhiqiang Song
INTRODUCTION: Chronic spontaneous urticaria (CSU) with autoreactivity is often resistant to antihistamines. Autologous whole blood injection (AWBI) has shown potential efficacy in the treatment of this disease, but it is controversial. It is necessary to screen patients who are suitable for this therapy in advance. This study aimed to identify biomarkers that predict the efficacy of AWBI treatment in CSU patients with autoreactivity. METHODS: A total of 30 patients with autologous serum skin test-positive CSU treated with AWBI were included in this study; urticaria activity score (UAS7) was recorded and the treatment response was judged based on it...
November 10, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37931604/erratum
#70
(no author information available yet)
No abstract text is available yet for this article.
November 6, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37926086/study-of-allergy-and-sensitization-relationship-in-children-and-parents-in-southern-china
#71
JOURNAL ARTICLE
Hui Gan, Zhifeng Huang, Huiqing Zhu, Aoli Li, Tong Chen, Ziyu Yin, Baoqing Sun
INTRODUCTION: The incidence of allergic diseases has increased globally, with genetics playing an essential role in these conditions' development. However, there is still a gap in understanding of how parental allergy status affects children's allergies. METHODS: An electronic questionnaire was used to assess allergy-related symptoms in kindergarten children and their parents, with a clinical diagnosis and concurrent serum allergen-specific immunoglobulin E (IgE), total IgE, and blood cell counts obtained...
November 3, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37926078/efficacy-of-a-non-pharmacological-intervention-in-seasonal-allergic-rhinitis-symptoms
#72
Davide Caimmi, Evangéline Clark, Paul Fogel, Nicolas Heddebaut, Michel Aubier, Pascal Demoly
BACKGROUND: Patients suffering from allergic rhinitis seek for several therapeutic symptomatic options, including nonconventional treatments, to control their symptoms. OBJECTIVES: Through the present proof-of-concept study, we prospectively investigated the potential role of Puressentiel® nasal protection spray (SNPA) in patients suffering from cypress pollen allergic rhinitis. METHODS: In 15 adults, we performed two nasal provocation tests, with a cypress pollen extract, with a 15-day interval, with and without previous randomized administration of SNPA, and evaluated a nasal symptom score, the nasal inspiratory peak flow, and the concentration of inflammatory cytokines in the nasal lavage after the procedures...
November 3, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37918371/increasing-prevalence-of-sensitization-to-cat-dog-allergens-in-the-covid-19-pandemic
#73
JOURNAL ARTICLE
Recep Evcen, Fatih Çölkesen, Eray Yıldız, Filiz Sadi Aykan, Mehmet Kılınç, Fatma Arzu Akkuş, Sevket Arslan
INTRODUCTION: Cat and dog allergens are common indoor triggers for respiratory allergies such as allergic rhinitis and asthma. This study aims to evaluate the prevalence of cat and dog allergies in adults and analyze changes during the COVID-19 pandemic. METHODS: We retrospectively analyzed the medical records of 8,102 patients who visited an allergy clinic and underwent skin prick testing (SPT) from March 2018 to March 2022: 2 years before and 2 years during the pandemic...
November 2, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37913762/association-of-dietary-polyunsaturated-fatty-acid-intake-with-allergic-rhinitis-in-adults-a-cross-sectional-study-of-nhanes-2005-2006
#74
JOURNAL ARTICLE
Wo-Er Jiao, Yang Xi, Di Li, Shan Xu, Yong-Gang Kong, Yu-Qin Deng, Rui Yang, Ze-Zhang Tao, Qing-Quan Hua, Shi-Ming Chen
INTRODUCTION: The incidence of allergic rhinitis (AR) is increasing year by year, and the pathogenesis is complex, in which diet may play an important role. The role of polyunsaturated fatty acids (PUFAs) in AR is still controversial. Previous studies have looked at the effects of PUFA during pregnancy, childhood, and adolescence. In this study, we aimed to determine the association between dietary intake of PUFA and AR in adults. METHODS: We used the NHANES database from 2005 to 2006 to include a total of 4,211 adult subjects...
November 1, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37906985/factors-affecting-the-ability-to-discontinue-oral-corticosteroid-use-in-patients-with-egpa-treated-with-anti-interleukin-5-therapy
#75
JOURNAL ARTICLE
Osamu Matsuno
INTRODUCTION: Patients with eosinophilic granulomatosis with polyangiitis (EGPA) and some with severe eosinophilic asthma require continuous long-term oral corticosteroid (OCS) treatment for disease control. The anti-interleukin-5 agent, mepolizumab, has recently become available for the treatment of severe eosinophilic asthma and EGPA, with promising results and safety profiles. The proportion of patients with EGPA who discontinued oral steroids was 18% in the MIRRA trial. To compare patients with EGPA who were able to discontinue steroids with mepolizumab with those who could not...
October 31, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37899044/prediction-of-food-sensitization-in-children-with-atopic-dermatitis-based-on-disease-severity-and-epidermal-layer-impairment
#76
JOURNAL ARTICLE
Nguyen Le Huong Tran, Nhung Thi My Ly, Hoang Kim Tu Trinh, Minh Kieu Le, Niem Van Thanh Vo, Duy Le Pham
INTRODUCTION: Atopic dermatitis (AD) is characterized by an impaired epidermal barrier, which could be associated with sensitization to food allergens (FAs) and/or inhaled allergens and contribute to the severity of AD. However, no clinical guidance has been established for evaluations of food sensitization (FS) in AD patients. This study investigated how AD severity and epidermal barrier impairment are associated with FS and factors that can predict FS in children with AD. METHODS: This cross-sectional study included 100 children (12-60 months) diagnosed with AD...
October 27, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37866360/systemic-type-2-inflammation-associated-atopic-dermatitis-exacerbates-periodontitis
#77
JOURNAL ARTICLE
Yuan Liu, Ziyuan Wang, Wenting Jiang, Yinchao Ma, Haoyan Wang, Yintong Xue, Yan Li, Xiang Gao, Jie Hao, Yuedan Wang, Feng Chen, Ming Chu
INTRODUCTION: Atopic dermatitis (AD) is a prevalent and chronic inflammatory skin disease characterized by Th2 cell-mediated type 2 inflammation. Emerging evidence indicated that AD patients exhibit an increased incidence of oral disorders. In the present study, we sought mechanistic insights into how AD affects periodontitis. METHODS: Onset of AD was induced by 2,4-dinitrochlorobenzene (DNCB). Furthermore, we induced periodontitis (P) in AD mice. The effect of AD in promoting inflammation and bone resorption in gingiva was evaluated...
October 20, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37852197/decreased-basophil-activation-against-house-dust-mite-after-japanese-cedar-pollen-subcutaneous-immunotherapy-a-retrospective-study
#78
Chisato Inuo, Hitoshi Ando, Kenichi Tanaka, Yoichi Nakajima, Ikuya Tsuge, Atsuo Urisu, Yasuto Kondo
BACKGROUND: Allergen-specific immunotherapy (AIT), an established treatment for allergic diseases, prevents the development of other allergic manifestations. Although the mechanisms remain unclear, AIT has been shown to reduce basophil activation (BA) against nontarget allergens. OBJECTIVES: The aim of this study was to assess immunological changes in Dermatophagoides farinae (Der f) after Japanese cedar pollen (JCP)-based subcutaneous immunotherapy (SCIT) monotherapy...
October 18, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37844549/atopy-does-not-influence-the-clinical-outcome-of-acute-urticaria-a-retrospective-study
#79
Xianjie Yang, Gaopeng Liang, Huan Wang, Minmin Kong, Zhiqiang Song, Qiquan Chen
BACKGROUND: Acute urticaria (AU) may be associated with atopy, but the relationship between atopic status and the clinical features of the disease has not been fully described. OBJECTIVES: The aim of the study was to determine the proportion of atopy in AU patients and to see whether atopy is related to the clinical characteristics of AU and whether it has an impact on the outcome of the disease. MATERIALS AND METHOD: A retrospective analysis of patients with AU was performed...
October 16, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37844548/inhaler-steroid-use-changes-oral-and-airway-bacterial-and-fungal-microbiome-profile-in-asthma-patients
#80
JOURNAL ARTICLE
Kıvılcım Oğuzülgen, Ayse Bilge Öztürk, Ayşe Bacceoğlu, Ömür Aydın, Gözde Köycü Buhari, Ebru Damadoğlu, Ferda Öner Erkekol, Özlem Göksel, Gül Karakaya, A Fuat Kalyoncu, Füsun Kalpaklıoğlu, Dilşad Mungan, Haluk Türktaş, Leyla Pur Özyiğit, Çağrı Ergin, Merve Erdoğan, Ayşe Kalkancı
INTRODUCTION: The full spectrum of bacterial and fungal species in adult asthma and the effect of inhaled corticosteroid use is not well described. The aim was to collect mouthwash and induced sputum samples from newly diagnosed asthma patients in the pretreatment period and in chronic asthma patients while undergoing regular maintenance inhaled corticosteroid therapy, in order to demonstrate the bacterial and fungal microbiome profile. METHODS: The study included 28 asthmatic patients on inhaler steroid therapy, 25 steroid-naive asthmatics, and 24 healthy controls...
October 16, 2023: International Archives of Allergy and Immunology
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