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Journals International Archives of Alle...

International Archives of Allergy and Immunology

https://read.qxmd.com/read/37926086/study-of-allergy-and-sensitization-relationship-in-children-and-parents-in-southern-china
#41
JOURNAL ARTICLE
Hui Gan, Zhifeng Huang, Huiqing Zhu, Aoli Li, Tong Chen, Ziyu Yin, Baoqing Sun
INTRODUCTION: The incidence of allergic diseases has increased globally, with genetics playing an essential role in these conditions' development. However, there is still a gap in understanding of how parental allergy status affects children's allergies. METHODS: An electronic questionnaire was used to assess allergy-related symptoms in kindergarten children and their parents, with a clinical diagnosis and concurrent serum allergen-specific immunoglobulin E (IgE), total IgE, and blood cell counts obtained...
November 3, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37926078/efficacy-of-a-non-pharmacological-intervention-in-seasonal-allergic-rhinitis-symptoms
#42
Davide Caimmi, Evangéline Clark, Paul Fogel, Nicolas Heddebaut, Michel Aubier, Pascal Demoly
BACKGROUND: Patients suffering from allergic rhinitis seek for several therapeutic symptomatic options, including nonconventional treatments, to control their symptoms. OBJECTIVES: Through the present proof-of-concept study, we prospectively investigated the potential role of Puressentiel® nasal protection spray (SNPA) in patients suffering from cypress pollen allergic rhinitis. METHODS: In 15 adults, we performed two nasal provocation tests, with a cypress pollen extract, with a 15-day interval, with and without previous randomized administration of SNPA, and evaluated a nasal symptom score, the nasal inspiratory peak flow, and the concentration of inflammatory cytokines in the nasal lavage after the procedures...
November 3, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37918371/increasing-prevalence-of-sensitization-to-cat-dog-allergens-in-the-covid-19-pandemic
#43
JOURNAL ARTICLE
Recep Evcen, Fatih Çölkesen, Eray Yıldız, Filiz Sadi Aykan, Mehmet Kılınç, Fatma Arzu Akkuş, Sevket Arslan
INTRODUCTION: Cat and dog allergens are common indoor triggers for respiratory allergies such as allergic rhinitis and asthma. This study aims to evaluate the prevalence of cat and dog allergies in adults and analyze changes during the COVID-19 pandemic. METHODS: We retrospectively analyzed the medical records of 8,102 patients who visited an allergy clinic and underwent skin prick testing (SPT) from March 2018 to March 2022: 2 years before and 2 years during the pandemic...
November 2, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37913762/association-of-dietary-polyunsaturated-fatty-acid-intake-with-allergic-rhinitis-in-adults-a-cross-sectional-study-of-nhanes-2005-2006
#44
JOURNAL ARTICLE
Wo-Er Jiao, Yang Xi, Di Li, Shan Xu, Yong-Gang Kong, Yu-Qin Deng, Rui Yang, Ze-Zhang Tao, Qing-Quan Hua, Shi-Ming Chen
INTRODUCTION: The incidence of allergic rhinitis (AR) is increasing year by year, and the pathogenesis is complex, in which diet may play an important role. The role of polyunsaturated fatty acids (PUFAs) in AR is still controversial. Previous studies have looked at the effects of PUFA during pregnancy, childhood, and adolescence. In this study, we aimed to determine the association between dietary intake of PUFA and AR in adults. METHODS: We used the NHANES database from 2005 to 2006 to include a total of 4,211 adult subjects...
November 1, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37906985/factors-affecting-the-ability-to-discontinue-oral-corticosteroid-use-in-patients-with-egpa-treated-with-anti-interleukin-5-therapy
#45
JOURNAL ARTICLE
Osamu Matsuno
INTRODUCTION: Patients with eosinophilic granulomatosis with polyangiitis (EGPA) and some with severe eosinophilic asthma require continuous long-term oral corticosteroid (OCS) treatment for disease control. The anti-interleukin-5 agent, mepolizumab, has recently become available for the treatment of severe eosinophilic asthma and EGPA, with promising results and safety profiles. The proportion of patients with EGPA who discontinued oral steroids was 18% in the MIRRA trial. To compare patients with EGPA who were able to discontinue steroids with mepolizumab with those who could not...
October 31, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37899044/prediction-of-food-sensitization-in-children-with-atopic-dermatitis-based-on-disease-severity-and-epidermal-layer-impairment
#46
JOURNAL ARTICLE
Nguyen Le Huong Tran, Nhung Thi My Ly, Hoang Kim Tu Trinh, Minh Kieu Le, Niem Van Thanh Vo, Duy Le Pham
INTRODUCTION: Atopic dermatitis (AD) is characterized by an impaired epidermal barrier, which could be associated with sensitization to food allergens (FAs) and/or inhaled allergens and contribute to the severity of AD. However, no clinical guidance has been established for evaluations of food sensitization (FS) in AD patients. This study investigated how AD severity and epidermal barrier impairment are associated with FS and factors that can predict FS in children with AD. METHODS: This cross-sectional study included 100 children (12-60 months) diagnosed with AD...
October 27, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37866360/systemic-type-2-inflammation-associated-atopic-dermatitis-exacerbates-periodontitis
#47
JOURNAL ARTICLE
Yuan Liu, Ziyuan Wang, Wenting Jiang, Yinchao Ma, Haoyan Wang, Yintong Xue, Yan Li, Xiang Gao, Jie Hao, Yuedan Wang, Feng Chen, Ming Chu
INTRODUCTION: Atopic dermatitis (AD) is a prevalent and chronic inflammatory skin disease characterized by Th2 cell-mediated type 2 inflammation. Emerging evidence indicated that AD patients exhibit an increased incidence of oral disorders. In the present study, we sought mechanistic insights into how AD affects periodontitis. METHODS: Onset of AD was induced by 2,4-dinitrochlorobenzene (DNCB). Furthermore, we induced periodontitis (P) in AD mice. The effect of AD in promoting inflammation and bone resorption in gingiva was evaluated...
October 20, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37866349/histological-phenotyping-in-eosinophilic-esophagitis-localized-proximal-disease-is-infrequent-but-associated-with-less-severe-disease-and-better-disease-outcome
#48
JOURNAL ARTICLE
Alexis Heil, Tobias Kuehlewindt, Anne Godat, Hans-Uwe Simon, Dagmar Simon, Philipp Schreiner, Catherine Saner, Stephan R Vavricka, Luc Biedermann, Ekaterina Safroneeva, Jean-Benoit Rossel, Andreas Limacher, Alex Straumann, Alain M Schoepfer, Thomas Greuter
INTRODUCTION: It is still unknown whether eosinophilic esophagitis (EoE) patients with localized disease are different from those with extended disease. METHODS: We evaluated prospectively included patients in the Swiss EoE cohort. Data on all patients with active disease at baseline, no concomitant gastroesophageal reflux disease, no strictures at baseline, and at least one follow-up visit were analyzed. We compared patients with histologically localized proximal versus distal versus extended (=proximal and distal) disease with regard to patient, disease characteristics, disease presentation, and development of complications...
October 20, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37852197/decreased-basophil-activation-against-house-dust-mite-after-japanese-cedar-pollen-subcutaneous-immunotherapy-a-retrospective-study
#49
Chisato Inuo, Hitoshi Ando, Kenichi Tanaka, Yoichi Nakajima, Ikuya Tsuge, Atsuo Urisu, Yasuto Kondo
BACKGROUND: Allergen-specific immunotherapy (AIT), an established treatment for allergic diseases, prevents the development of other allergic manifestations. Although the mechanisms remain unclear, AIT has been shown to reduce basophil activation (BA) against nontarget allergens. OBJECTIVES: The aim of this study was to assess immunological changes in Dermatophagoides farinae (Der f) after Japanese cedar pollen (JCP)-based subcutaneous immunotherapy (SCIT) monotherapy...
October 18, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37844549/atopy-does-not-influence-the-clinical-outcome-of-acute-urticaria-a-retrospective-study
#50
Xianjie Yang, Gaopeng Liang, Huan Wang, Minmin Kong, Zhiqiang Song, Qiquan Chen
BACKGROUND: Acute urticaria (AU) may be associated with atopy, but the relationship between atopic status and the clinical features of the disease has not been fully described. OBJECTIVES: The aim of the study was to determine the proportion of atopy in AU patients and to see whether atopy is related to the clinical characteristics of AU and whether it has an impact on the outcome of the disease. MATERIALS AND METHOD: A retrospective analysis of patients with AU was performed...
October 16, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37844548/inhaler-steroid-use-changes-oral-and-airway-bacterial-and-fungal-microbiome-profile-in-asthma-patients
#51
JOURNAL ARTICLE
Kıvılcım Oğuzülgen, Ayse Bilge Öztürk, Ayşe Bacceoğlu, Ömür Aydın, Gözde Köycü Buhari, Ebru Damadoğlu, Ferda Öner Erkekol, Özlem Göksel, Gül Karakaya, A Fuat Kalyoncu, Füsun Kalpaklıoğlu, Dilşad Mungan, Haluk Türktaş, Leyla Pur Özyiğit, Çağrı Ergin, Merve Erdoğan, Ayşe Kalkancı
INTRODUCTION: The full spectrum of bacterial and fungal species in adult asthma and the effect of inhaled corticosteroid use is not well described. The aim was to collect mouthwash and induced sputum samples from newly diagnosed asthma patients in the pretreatment period and in chronic asthma patients while undergoing regular maintenance inhaled corticosteroid therapy, in order to demonstrate the bacterial and fungal microbiome profile. METHODS: The study included 28 asthmatic patients on inhaler steroid therapy, 25 steroid-naive asthmatics, and 24 healthy controls...
October 16, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37729879/drug-allergy-in-children-adverse-reactions-after-skin-testing
#52
JOURNAL ARTICLE
Cagla Karavaizoglu, Ayse Suleyman, Roza Yavuz Alıc, Kazım Okan Dolu, Esra Yucel, Zeynep Hızlı Demirkale, Sevgi Sipahi Cimen, Cevdet Ozdemir, Zeynep Ulker Tamay
INTRODUCTION: Skin tests are one of the most widely used diagnostic tools for suspected drug allergies in children. Studies on systemic reactions occurring during skin testing with allergens have mostly been conducted in pediatric and adult patient groups together. However, data on adverse reactions including allergic reactions after drug skin tests in children are scarce. It is aimed to determine the adverse reactions after skin test in children with suspected drug allergy. METHODS: Patients who underwent a drug skin test due to the suspicion of drug allergy between May 2017 and June 2020 were evaluated, retrospectively...
September 20, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37725935/mir-410-regulates-helper-t-cell-differentiation-in-ovalbumin-induced-asthma-through-the-pi3k-akt-vegf-signaling-pathway
#53
JOURNAL ARTICLE
Nianting Tong, Dongyun Liu, Ling Lu, Rongjun Lin, Rong Jin
INTRODUCTION: Asthma has been attributed to Th1/Th2 imbalance and inappropriate Th2 responses to environmental allergens. MicroRNAs (miRNAs), 21 to 23 RNA molecules, are first found in mammals and have been implicated in various biological activities. Our previous study found that miR-410 effectively ameliorates airway inflammation in the ovalbumin (OVA)-induced asthma murine model. However, the role of miR-410 in regulating helper T (Th) cell differentiation is not clear. In the present study, we aimed to explore the regulatory effects of miR-410 on the differentiation of Th cells through both in vivo and in vitro studies...
September 19, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37725920/safety-of-oral-food-challenge-for-individuals-with-low-egg-white-and-ovomucoid-specific-ige-antibodies
#54
JOURNAL ARTICLE
Mika Ogata, Takanobu Yoshida, Jun Kido, Natsuko Nishi, Sachiko Shimomura, Nami Hirai, Masaaki Yanai, Tomoyuki Mizukami, Kimitoshi Nakamura
INTRODUCTION: During an oral food challenge (OFC), there is a risk of adverse reactions, including anaphylaxis. Therefore, the physician should carefully conduct the OFC. This study aimed to evaluate the OFC results in individuals with low levels of egg white (EW)- and ovomucoid (OVM)-specific immunoglobulin E (sIgE) and the safety of a hen's egg (HE) OFC in these individuals. METHODS: A total of 2,058 individuals with low EW- or OVM-sIgE underwent HE-OFC at two institutions in Kumamoto prefecture, located in the western area of Japan, between January 1, 2017, and December 31, 2021, within 1 year of recorded sIgE measurements...
September 19, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37722364/a-decade-of-pathogenesis-advances-in-non-type-2-inflammatory-endotypes-in-chronic-rhinosinusitis-2012-2022
#55
REVIEW
Na Cui, Xuewei Zhu, Chen Zhao, Cuida Meng, Jichao Sha, Dongdong Zhu
Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by localized inflammation of the upper airways. CRS includes two main phenotypes, namely, CRS with nasal polyps and CRS without nasal polyps. The phenotype-based classification method cannot reflect the pathological mechanism. The endotype-based classification method has been paid more and more attention by researchers. It is mainly divided into type 2 and non-type 2 endotypes. The mechanism driving the pathogenesis of non-type 2 inflammation is currently unknown...
September 18, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37717570/regulation-of-t-helper-cell-type-2-immune-response-by-controlling-beta-2-adrenergic-receptor-in-dendritic-cells-of-patients-with-allergic-rhinitis
#56
JOURNAL ARTICLE
Ji Woo Yeon, Byoungjae Kim, Junhyoung Byun, Semyoung Jung, Jaehyung Park, Munsoo Han, Seung-Kuk Baek, Tae Hoon Kim
INTRODUCTION: Allergic diseases are mediated by T helper cell type 2 (Th2) cells, which are differentiated by dendritic cells (DCs). Recently, it was reported that cAMP concentration in DCs is important for inducing allergic responses. However, the regulatory function of cAMP in DCs in Th2 immune responses is unclear. It was hypothesized that the regulation of G protein-coupled receptors (GPCRs) to increase cAMP levels in DCs would reduce Th2 immune responses. METHODS: Human DCs from patients with allergic rhinitis (AR) and from healthy controls were subjected to next-generation sequencing (NGS) to identify potential GPCR...
September 15, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37703833/cold-atmospheric-plasma-a-promising-and-safe-therapeutic-strategy-for-atopic-dermatitis
#57
REVIEW
Fan Bai, Yutong Ran, Siyue Zhai, Yumin Xia
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Microbial infection, immune system dysfunction, and skin barrier defunctionalization have been regarded as the central events in AD pathogenesis. Cold atmospheric plasma (CAP) is an unbound system composed of many free electrons, ions, and neutral particles, with macroscopic time and spatial scales. Based on dielectric barrier discharge, glow discharge, corona discharge, or arch discharge, CAP is generated at normal atmospheric pressure. Its special physical properties maintain its temperature at 20°C-40°C, combining the advantages of high safety and strong ionic activity...
September 13, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37690448/low-density-lipoprotein-cholesterol-is-associated-with-atopic-dermatitis-in-korean-adolescents
#58
JOURNAL ARTICLE
Min Kyeong Seong, Meeyong Shin
INTRODUCTION: Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases. Several studies have investigated the relationship between obesity and AD prevalence, but the results have been conflicting. This study investigated the association between obesity and AD in Korean adolescents. METHODS: We used nationally representative data regarding 1,617 Korean adolescents aged 12-18 years, which were obtained from the cross-sectional Korea National Health and Nutrition Examination Survey 2017-2019...
September 8, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37690443/airway-microbiome-composition-and-co-occurrence-network-are-associated-with-inflammatory-phenotypes-of-asthma
#59
JOURNAL ARTICLE
Yi Li, Congying Zou, Jieying Li, Wen Wang, Feiran Wang, Yue Guo
INTRODUCTION: The composition and co-occurrence network of the airway microbiome might influence the asthma inflammatory phenotype. Airway microbiota change with asthma phenotypes, and the structure of the bacterial community in the airway might differ between different asthma inflammatory phenotypes and may also influence therapy results. Identifying airway microbiota can help to investigate the role that microbiota play in the asthma inflammatory process. METHODS: Induced sputum from 55 subjects and 12 healthy subjects from Beijing, China, was collected and analyzed for bacterial microbiota...
September 8, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37673053/how-does-pregnancy-and-type-of-delivery-affect-the-clinical-course-of-hereditary-angioedema
#60
JOURNAL ARTICLE
Deniz Eyice Karabacak, Ali Can, Semra Demir, Osman Ozan Yegit, Bahauddin Colakoglu, Suna Buyukozturk, Aslı Akkor Gelincik
INTRODUCTION: Knowledge on the clinical course of hereditary angioedema (HAE) during pregnancy, delivery, and breastfeeding is very limited. In this study, we aimed to evaluate the course of HAE during these periods. METHODS: The HAE attacks C1-INH prophylaxis before and during pregnancy and during breastfeeding, and the delivery types were retrospectively determined. The severity of attacks was assessed by a 10-point Visual Analogue Scale (VAS). RESULTS: We evaluated 88 pregnancies in 48 HAE patients among whom 20 were primiparous...
September 6, 2023: International Archives of Allergy and Immunology
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