Journals International Archives of Alle...

International Archives of Allergy and Immunology
Xianjie Yang, Gaopeng Liang, Huan Wang, Minmin Kong, Zhiqiang Song, Qiquan Chen
BACKGROUND: Acute urticaria (AU) may be associated with atopy, but the relationship between atopic status and the clinical features of the disease has not been fully described. OBJECTIVES: The aim of the study was to determine the proportion of atopy in AU patients and to see whether atopy is related to the clinical characteristics of AU and whether it has an impact on the outcome of the disease. MATERIALS AND METHOD: A retrospective analysis of patients with AU was performed...
October 16, 2023: International Archives of Allergy and Immunology
Kıvılcım Oğuzülgen, Ayse Bilge Öztürk, Ayşe Bacceoğlu, Ömür Aydın, Gözde Köycü Buhari, Ebru Damadoğlu, Ferda Öner Erkekol, Özlem Göksel, Gül Karakaya, A Fuat Kalyoncu, Füsun Kalpaklıoğlu, Dilşad Mungan, Haluk Türktaş, Leyla Pur Özyiğit, Çağrı Ergin, Merve Erdoğan, Ayşe Kalkancı
INTRODUCTION: The full spectrum of bacterial and fungal species in adult asthma and the effect of inhaled corticosteroid use is not well described. The aim was to collect mouthwash and induced sputum samples from newly diagnosed asthma patients in the pretreatment period and in chronic asthma patients while undergoing regular maintenance inhaled corticosteroid therapy, in order to demonstrate the bacterial and fungal microbiome profile. METHODS: The study included 28 asthmatic patients on inhaler steroid therapy, 25 steroid-naive asthmatics, and 24 healthy controls...
October 16, 2023: International Archives of Allergy and Immunology
Ting-Yi Chiang, Hsiang-Ying Lee, Wei-Chen Chien, Hsiao-Chun Su, Yung-Chun Su, Chung-Wei Lin
INTRODUCTION: Sexual dysfunction (SD) and allergic disease are common health concerns worldwide and bear a potential relationship. This scoping review is conducted to analyze the currently available data regarding the associations between these two health issues. METHODS: A comprehensive literature search was performed in the databases of PubMed, MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science to retrieve studies that were published before January 2023...
September 20, 2023: International Archives of Allergy and Immunology
Cagla Karavaizoglu, Ayse Suleyman, Roza Yavuz Alıc, Kazım Okan Dolu, Esra Yucel, Zeynep Hızlı Demirkale, Sevgi Sipahi Cimen, Cevdet Ozdemir, Zeynep Ulker Tamay
INTRODUCTION: Skin tests are one of the most widely used diagnostic tools for suspected drug allergies in children. Studies on systemic reactions occurring during skin testing with allergens have mostly been conducted in pediatric and adult patient groups together. However, data on adverse reactions including allergic reactions after drug skin tests in children are scarce. It is aimed to determine the adverse reactions after skin test in children with suspected drug allergy. METHODS: Patients who underwent a drug skin test due to the suspicion of drug allergy between May 2017 and June 2020 were evaluated, retrospectively...
September 20, 2023: International Archives of Allergy and Immunology
Nianting Tong, Dongyun Liu, Ling Lu, Rongjun Lin, Rong Jin
INTRODUCTION: Asthma has been attributed to Th1/Th2 imbalance and inappropriate Th2 responses to environmental allergens. MicroRNAs (miRNAs), 21 to 23 RNA molecules, are first found in mammals and have been implicated in various biological activities. Our previous study found that miR-410 effectively ameliorates airway inflammation in the ovalbumin (OVA)-induced asthma murine model. However, the role of miR-410 in regulating helper T (Th) cell differentiation is not clear. In the present study, we aimed to explore the regulatory effects of miR-410 on the differentiation of Th cells through both in vivo and in vitro studies...
September 19, 2023: International Archives of Allergy and Immunology
Mika Ogata, Takanobu Yoshida, Jun Kido, Natsuko Nishi, Sachiko Shimomura, Nami Hirai, Masaaki Yanai, Tomoyuki Mizukami, Kimitoshi Nakamura
INTRODUCTION: During an oral food challenge (OFC), there is a risk of adverse reactions, including anaphylaxis. Therefore, the physician should carefully conduct the OFC. This study aimed to evaluate the OFC results in individuals with low levels of egg white (EW)- and ovomucoid (OVM)-specific immunoglobulin E (sIgE) and the safety of a hen's egg (HE) OFC in these individuals. METHODS: A total of 2,058 individuals with low EW- or OVM-sIgE underwent HE-OFC at two institutions in Kumamoto prefecture, located in the western area of Japan, between January 1, 2017, and December 31, 2021, within 1 year of recorded sIgE measurements...
September 19, 2023: International Archives of Allergy and Immunology
Na Cui, Xuewei Zhu, Chen Zhao, Cuida Meng, Jichao Sha, Dongdong Zhu
Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by localized inflammation of the upper airways. CRS includes two main phenotypes, namely, CRS with nasal polyps and CRS without nasal polyps. The phenotype-based classification method cannot reflect the pathological mechanism. The endotype-based classification method has been paid more and more attention by researchers. It is mainly divided into type 2 and non-type 2 endotypes. The mechanism driving the pathogenesis of non-type 2 inflammation is currently unknown...
September 18, 2023: International Archives of Allergy and Immunology
Ji Woo Yeon, Byoungjae Kim, Junhyoung Byun, Semyoung Jung, Jaehyung Park, Munsoo Han, Seung-Kuk Baek, Tae Hoon Kim
INTRODUCTION: Allergic diseases are mediated by T helper cell type 2 (Th2) cells, which are differentiated by dendritic cells (DCs). Recently, it was reported that cAMP concentration in DCs is important for inducing allergic responses. However, the regulatory function of cAMP in DCs in Th2 immune responses is unclear. It was hypothesized that the regulation of G protein-coupled receptors (GPCRs) to increase cAMP levels in DCs would reduce Th2 immune responses. METHODS: Human DCs from patients with allergic rhinitis (AR) and from healthy controls were subjected to next-generation sequencing (NGS) to identify potential GPCR...
September 15, 2023: International Archives of Allergy and Immunology
Fan Bai, Yutong Ran, Siyue Zhai, Yumin Xia
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Microbial infection, immune system dysfunction, and skin barrier defunctionalization have been regarded as the central events in AD pathogenesis. Cold atmospheric plasma (CAP) is an unbound system composed of many free electrons, ions, and neutral particles, with macroscopic time and spatial scales. Based on dielectric barrier discharge, glow discharge, corona discharge, or arch discharge, CAP is generated at normal atmospheric pressure. Its special physical properties maintain its temperature at 20°C-40°C, combining the advantages of high safety and strong ionic activity...
September 13, 2023: International Archives of Allergy and Immunology
Min Kyeong Seong, Meeyong Shin
INTRODUCTION: Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases. Several studies have investigated the relationship between obesity and AD prevalence, but the results have been conflicting. This study investigated the association between obesity and AD in Korean adolescents. METHODS: We used nationally representative data regarding 1,617 Korean adolescents aged 12-18 years, which were obtained from the cross-sectional Korea National Health and Nutrition Examination Survey 2017-2019...
September 8, 2023: International Archives of Allergy and Immunology
Yi Li, Congying Zou, Jieying Li, Wen Wang, Feiran Wang, Yue Guo
INTRODUCTION: The composition and co-occurrence network of the airway microbiome might influence the asthma inflammatory phenotype. Airway microbiota change with asthma phenotypes, and the structure of the bacterial community in the airway might differ between different asthma inflammatory phenotypes and may also influence therapy results. Identifying airway microbiota can help to investigate the role that microbiota play in the asthma inflammatory process. METHODS: Induced sputum from 55 subjects and 12 healthy subjects from Beijing, China, was collected and analyzed for bacterial microbiota...
September 8, 2023: International Archives of Allergy and Immunology
Deniz Eyice Karabacak, Ali Can, Semra Demir, Osman Ozan Yegit, Bahauddin Colakoglu, Suna Buyukozturk, Aslı Akkor Gelincik
INTRODUCTION: Knowledge on the clinical course of hereditary angioedema (HAE) during pregnancy, delivery, and breastfeeding is very limited. In this study, we aimed to evaluate the course of HAE during these periods. METHODS: The HAE attacks C1-INH prophylaxis before and during pregnancy and during breastfeeding, and the delivery types were retrospectively determined. The severity of attacks was assessed by a 10-point Visual Analogue Scale (VAS). RESULTS: We evaluated 88 pregnancies in 48 HAE patients among whom 20 were primiparous...
September 6, 2023: International Archives of Allergy and Immunology
Lydia Lam, Melinda Jiang, Stephen Bacchi, Joshua Kovoor, Joshua M Inglis, Sepehr Shakib, Carlo Yuson, William Smith
INTRODUCTION: Trimethoprim-sulfamethoxazole (TMP-SMX) is an important antibiotic, with the most compelling indications for Pneumocystis jirovecii pneumonia prophylaxis and methicillin-resistant Staphylococcus aureus treatment. Previous adverse reactions (AR) to TMP-SMX may limit the usability of TMP-SMX. Electronic medical record (EMR) of AR for other antibiotics has previously been shown to be inaccurate; however, the extent to which this occurs for TMP-SMX is unknown. METHODS: A multi-centre retrospective observational study was conducted for consecutive inpatient admissions over a 2...
September 6, 2023: International Archives of Allergy and Immunology
Liping Liu, Weihua Wang, Yuemei Sun, Guangrun Li
INTRODUCTION: Many parents of children with allergies are worried whether their subsequent children will have allergic reactions to the same allergens. Much of the current research on sibling allergens has been focused on twins; however, in real life, very few children are twins. Our study provides an opportunity to initially explore the sensitivity to allergens in siblings diagnosed with respiratory allergic diseases. METHODS: Siblings diagnosed with bronchial asthma and/or allergic rhinitis in the Outpatient Department of Allergy Department of Yantai Yuhuangding Hospital from January 2018 to December 2021 were selected...
September 5, 2023: International Archives of Allergy and Immunology
Hanrui Wang, Jianwei Wang, Zheying Song, Jing Guo, Yujuan Yang, Zi Liu, Yuemei Sun, Liping Liu, Yu Zhang, Xicheng Song
INTRODUCTION: Specific pathogen infections associated with acute rhinosinusitis (ARS) in infants are risk factors for allergic asthma in adolescents. However, the risk factors for ARS onset remain largely unknown in asthmatic children. In this study, we aim to investigate the risk factors for ARS in childhood asthma. METHODS: This study retrospectively compared and analyzed the clinical characteristics of asthmatic children with (n = 194) or without ARS (n = 799)...
September 5, 2023: International Archives of Allergy and Immunology
Akihiro Maeta, Yuri Takaoka, Masaaki Hamada, Atsuko Nakano, Shinichi Sumimoto, Kaori Anzai, Yukiko Tanaka, Satoru Morikawa, Makoto Kameda, Kyoko Takahashi
INTRODUCTION: Oral immunotherapy (OIT) imposes a burden on parents and their children with food allergies (FAs). We already developed a questionnaire for OIT-related Parental Burden (OIT-PB) scale. However, the previous questionnaire had some problems. This study modified OIT-PB and verified its reliability and validity. METHODS: A 20-item draft covering the physical and mental burdens caused by OIT was prepared jointly with multiple allergists. The Food Allergy Quality of Life Questionnaire-Parental Burden (FAQLQ-PB) and Stress Response Scale-18 (SRS-18) were used to verify concurrent validity...
August 30, 2023: International Archives of Allergy and Immunology
Emiri Sato, Yukako Seo, Etsuko Tagaya, Osamitsu Yagi, Yukie Yamamura, Manabu Nonaka
INTRODUCTION: Eosinophilic otitis media (EOM) is well-known to frequently co-exist with adult-onset asthma. Both diseases are similar type 2 inflammation and are considered to have a "one airway, one disease" relationship. Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO), characterized by airway obstruction caused by airway wall thickening (AWT), is a severe condition with a higher incidence of mortality compared to asthma alone or COPD alone. Based on the "one airway, one disease" concept, we hypothesized that the inflammatory pathophysiology of EOM differs depending on its comorbidity with ACO or with asthma alone...
August 24, 2023: International Archives of Allergy and Immunology
Lin Yang, Wenjing Li, Shanshan Qi, Qing Jiang, Nan Huang, Yaqi Yang, Dongxia Ma, Wei Zhang, Hao Chen, Rongfei Zhu
INTRODUCTION: Airborne fungi induce allergic symptoms in 3-10% of the population worldwide. To better prevent and manage fungi-related allergic diseases, it is essential to identify the genus and the distribution profile of airborne fungi. METHODS: With this purpose in mind, we carried out a 12-month volumetric sampling study to monitor the airborne fungi and retrospectively analyzed the sensitization profile of four dominant fungi (Cladosporium, Alternaria, Aspergillus, and Penicillium) among respiratory allergies during the same study period in Wuhan, China...
August 23, 2023: International Archives of Allergy and Immunology
Muneyuki Shimizu, Taisuke Kato, Yuichi Adachi, Takuya Wada, Shokei Murakami, Yasunori Ito, Toshiko Itazawa, Yoko S Adachi, Akiko Tsuchida, Kenta Matsumura, Kei Hamazaki, Hidekuni Inadera
INTRODUCTION: Vitamin D plays an important role in the immune system, and postnatal vitamin D insufficiency is one of the risk factors for the development of allergic disease. However, the effects of women's vitamin D intake during pregnancy on the prevalence of allergic disease in their children remain controversial. METHODS: From the Japan Environment and Children's Study, an ongoing nationwide birth cohort study, we obtained information on maternal dietary vitamin D intake determined using a food frequency questionnaire and parent-reported allergic disease symptoms based on the ISAAC questionnaire in children at 3 years of age...
August 22, 2023: International Archives of Allergy and Immunology
Gaopeng Liang, Jie Zhou, Lanlan Jiang, Wenwen Wang, Qijun Wu, Cuie Gao, Wenying Liu, Shifei Li, Shujing Feng, Zhiqiang Song
INTRODUCTION: Allergen-specific IgE (sIgE) sensitization exists in a considerable fraction of chronic spontaneous urticaria (CSU) patients. Basophils have been implicated in the pathogenesis of CSU. This paper aimed to explore the relationship between allergic sensitization and basophil reactivity in CSU and the possible underlying mechanism. METHODS: Basophil-enriched leukocytes were isolated from the peripheral blood of 76 CSU patients and 9 healthy controls. Basophil CD63 and FcεRIα (the alpha subunit of the high-affinity IgE receptor) expression in the blood samples with various house dust mite (HDM)-sIgE levels were determined by flow cytometry...
August 21, 2023: International Archives of Allergy and Immunology
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